category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	19/166	238/9376	4.50906145590766	PLCG2/RPL3/RPL18A/RPS4X/RPS5/RPL13/RPL12/RPS14/RPL10A/RPL18/RPS9/RPS18/RPL8/RPS27A/NRP1/RPL7A/RPLP1/RPS7/RPS12	7.36145638078818
Genetic Information Processing	Translation	hsa03010	Ribosome	17/166	222/9376	4.32519266254206	RPL3/RPL18A/RPS4X/RPS5/RPL13/RPL12/RPS14/RPL10A/RPL18/RPS9/RPS18/RPL8/RPS27A/RPL7A/RPLP1/RPS7/RPS12	6.731280892675
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	16/166	227/9376	3.98110503688764	SLC26A2/MT-CYB/MGST3/MT-ATP8/GSTA3/GSTO1/NDUFB10/MT-ND6/NDUFV2/NDUFS8/HRAS/COX5A/NDUFB9/SOD1/MT-CO2/SLC25A6	6.1039822246933
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	17/166	308/9376	3.11750899702707	MT-CYB/MT-ATP8/TGM2/AP2S1/TUBB4B/CLTA/NDUFB10/MT-ND6/NDUFV2/NDUFS8/GPX1/COX5A/NDUFB9/SOD1/TBPL1/MT-CO2/SLC25A6	5.07288169134742
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	14/166	235/9376	3.36488079979492	MT-CYB/MT-ATP8/SLC25A29/ADCY2/NDUFB10/MT-ND6/NDUFV2/NDUFS8/HRAS/COX20/COX5A/NDUFB9/COX19/MT-CO2	4.92897027521526
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/166	59/9376	6.70124566060854	MGST3/GSTA3/GSTP1/GSTO1/GPX4/GPX1/LAP3	5.89749498013568
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	14/166	268/9376	2.95054846250674	UBB/MT-CYB/MT-ATP8/TUBB4B/NDUFB10/MT-ND6/NDUFV2/NDUFS8/RPS27A/COX5A/NDUFB9/SOD1/MT-CO2/SLC25A6	4.34933137978097
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/166	138/9376	3.68360398114196	MT-CYB/MT-ATP8/NDUFB10/MT-ND6/NDUFV2/NDUFS8/COX5A/NDUFB9/MT-CO2	4.26362361374469
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/166	170/9376	3.32246633593196	GADD45G/MGST3/CTNNB1/PLCG2/GSTA3/GSTP1/GADD45B/GSTO1/LRP5/HRAS	4.1024969812722
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/166	205/9376	3.03073758448428	MT-CYB/MT-ATP8/NDUFB10/MT-ND6/NDUFV2/MPC2/NDUFS8/COX5A/NDUFB9/MT-CO2/SLC25A6	3.94668311501168
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	13/166	275/9376	2.6700547645126	MT-CYB/MT-ATP8/TUBB4B/HSPA8/NDUFB10/MT-ND6/NDUFV2/NDUFS8/COX5A/NDUFB9/SOD1/MT-CO2/SLC25A6	3.77365653476996
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/166	93/9376	4.25132789221402	ATP2B1/ATP1A4/ATP1B3/KCNN4/ADCY2/CST3/SLC4A2	4.23026852429398
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	8/166	122/9376	3.70373296464547	CTNNB1/ATP1A4/PLCG2/ITGAV/ATP1B3/MDM2/HRAS/MED16	4.03542082608011
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/166	50/9376	5.64819277108434	CKMT1A/CKB/CKMT1B/LAP3/ALDH7A1	4.42416478582238
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	18/166	480/9376	2.11807228915663	UBB/MT-CYB/MT-ATP8/CTNNB1/TUBB4B/NDUFB10/MT-ND6/NDUFV2/LRP5/NDUFS8/HRAS/GPX1/RPS27A/COX5A/NDUFB9/SOD1/MT-CO2/SLC25A6	3.3760042333059
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/166	31/9376	7.28799067236689	ACSS1/GLUL/GLDC/GCSH	4.70774520803372
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/166	75/9376	4.51855421686747	MGST3/GSTA3/GSTP1/MDM2/GSTO1/PMAIP1	4.10714394480916
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/166	53/9376	5.32848374630598	ATP2B1/ATP1A4/ATP1B3/AP2S1/CLTA	4.24234272538048
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/166	17/9376	9.96739900779589	CA8/GLUL/CPS1	4.96805160600221
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/166	37/9376	6.1061543471182	GADD45G/CTNNB1/GADD45B/HRAS	4.17786574440827
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/166	233/9376	2.42411706913491	FBN2/ATP1A4/ITGB4/ITGAV/ATP1B3/FBN1/MYH10/PDLIM2/DIAPH2/CSRP2	2.95521552457063
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	14/166	388/9376	2.03800770090672	MT-CYB/MT-ATP8/CTNNB1/TUBB4B/NDUFB10/MT-ND6/NDUFV2/LRP5/NDUFS8/HRAS/COX5A/NDUFB9/MT-CO2/SLC25A6	2.80346264431728
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/166	166/9376	2.72202061257077	ATP2B1/ATP1A4/ATP1B3/GNA12/ADCY2/PDE3B/VASP/SLC25A6	3.00519350601485
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/166	75/9376	3.76546184738956	GADD45G/MDM2/GADD45B/PMAIP1/CCND2	3.22807300414964
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/166	76/9376	3.71591629676601	GADD45G/PLCG2/MDM2/GADD45B/HRAS	3.19147590580984
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/166	116/9376	2.92147901952638	ACSS1/GLDC/CPS1/TKT/GCSH/ECHS1	2.79556127072083
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/166	224/9376	2.26936316695353	NFYB/ADCY2/MSX2/HRAS/CCND2/HLA-DPB1/NRP1/TBPL1/SLC25A6	2.58143838062763
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/166	87/9376	3.24608779947376	MT-CYB/ATP1A4/ATP1B3/COX5A/MT-CO2	2.82560688942994
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/166	87/9376	3.24608779947376	GADD45G/CTNNB1/GADD45B/PMAIP1/HRAS	2.82560688942994
NA	NA	hsa04518	Integrin signaling	7/166	154/9376	2.56736035049288	LAMC2/PGF/CTNNB1/ITGB4/ITGAV/FBN1/CCND2	2.63285247251881
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/166	59/9376	3.82928323463345	GADD45G/CTNNB1/GADD45B/HRAS	2.92667333893692
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/166	157/9376	2.51830250940066	MT-CYB/NDUFB10/NDUFV2/NDUFS8/COX5A/NDUFB9/MT-CO2	2.57558623664977
Organismal Systems	Digestive system	hsa04976	Bile secretion	5/166	90/9376	3.13788487282463	ATP1A4/ATP1B3/ABCB1/ADCY2/SLC4A2	2.73590552528025
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/166	61/9376	3.70373296464547	ATP2B1/ATP1A4/ATP1B3/MT2A	2.84411498873221
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/166	62/9376	3.64399533618344	ADCY2/HSPA8/HRAS/SOD1	2.80413087867552
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	8/166	203/9376	2.22588877678201	LAMC2/PGF/CTNNB1/ITGB4/ITGAV/HRAS/CCND2/VASP	2.37057258907231
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	12/166	368/9376	1.84180199057098	MT-CYB/MT-ATP8/TUBB4B/NDUFB10/MT-ND6/NDUFV2/NDUFS8/GPX1/COX5A/NDUFB9/SOD1/MT-CO2	2.21171689808699
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/166	133/9376	2.54805688921098	GADD45G/MDM2/GADD45B/HRAS/FOXO4/CCND2	2.41388250721408
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/166	39/9376	4.34476367006488	GLDC/GCSH/ALDH7A1	2.80998452771827
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	9/166	250/9376	2.03334939759036	AP2S1/SLC17A5/FUCA1/CLTA/SLC38A9/AP5B1/TFEB/CTSC/MCOLN3	2.22324246902035
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/166	102/9376	2.76872194660997	ATP2B1/ATP1A4/ATP1B3/ADCY2/SLC4A2	2.41121519533142
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/166	137/9376	2.47366106762818	GADD45G/CFLAR/GADD45B/PMAIP1/HRAS/CTSC	2.33268059867705
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/166	70/9376	3.22753872633391	MGST3/GSTA3/GSTP1/GSTO1	2.5113233004883
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/166	41/9376	4.1328239788422	GLDC/GCSH/ALDH7A1	2.6988616899175
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/166	17/9376	6.64493267186393	MYH10/NRP2	3.12736355345038
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/166	103/9376	2.74184115101181	COL14A1/ATP1A4/ATP1B3/KCNN4/COL21A1	2.3863101919915
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/166	73/9376	3.09490014853936	MGST3/GSTA3/GSTP1/GSTO1	2.41225443899674
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/166	73/9376	3.09490014853936	GADD45G/MDM2/GADD45B/HRAS	2.41225443899674
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/166	73/9376	3.09490014853936	GADD45G/PLCG2/GADD45B/HRAS	2.41225443899674
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/166	142/9376	2.38656032581028	MGST3/CTNNB1/GSTA3/GSTP1/ITGAV/GSTO1	2.23510470934489
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/166	75/9376	3.01236947791165	ATP1A4/ATP1B3/ADCY2/GPX1	2.34900206349013
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/166	19/9376	5.94546607482562	GLDC/GCSH	2.89684714527158
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/166	76/9376	2.97273303741281	ATP1A4/ATP1B3/ADCY2/SLC4A2	2.31816052836199
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/166	77/9376	2.93412611484901	GADD45G/MDM2/GADD45B/HRAS	2.28782022375809
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/166	149/9376	2.27444004204738	ADCY2/NDUFB10/MT-ND6/NDUFV2/NDUFS8/NDUFB9	2.10519412458941
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/166	150/9376	2.25927710843373	GADD45G/CTNNB1/ABCB1/GADD45B/LRP5/HRAS	2.08722890369893
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/166	79/9376	2.85984444105536	MGST3/GSTA3/GSTP1/GSTO1	2.22858199907784
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/166	115/9376	2.45573598742797	AKAP13/GNA12/GCM1/ADCY2/LRP5	2.10868866517398
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/166	82/9376	2.7552159858948	MGST3/GSTA3/GSTP1/GSTO1	2.14311770862735
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/166	83/9376	2.72202061257077	PRDX1/PRDX5/SLC27A2/SOD1	2.11548178558629
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	6/166	157/9376	2.15854500805771	GADD45G/MDM2/GADD45B/HRAS/CCND2/SLC25A6	1.96530833533998
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	6/166	157/9376	2.15854500805771	AMOT/DLG5/CTNNB1/ID1/FRMD6/CCND2	1.96530833533998
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/166	158/9376	2.14488333079152	GADD45G/CDKN1C/MDM2/GADD45B/CCND2/TFDP2	1.94841422182349
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/166	23/9376	4.91147197485594	GLUL/CPS1	2.52138137755078
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/166	23/9376	4.91147197485594	ATP1A4/ATP1B3	2.52138137755078
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/166	86/9376	2.62706640515551	ATP1A4/ATP1B3/KCNN4/ADCY2	2.03496298405915
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/166	205/9376	1.92865119012636	CD44/GADD45G/PLCG2/MDM2/GADD45B/CCND2/HLA-DPB1	1.80480826267761
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/166	89/9376	2.53851360498172	CD44/LAMC2/ITGB4/ITGAV	1.95780074173945
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/166	93/9376	2.4293302241223	GADD45G/LAMC2/ITGAV/GADD45B	1.85968652143824
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/166	28/9376	4.03442340791738	B3GNT5/ST3GAL6	2.1587667029574
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/166	98/9376	2.30538480452422	ATP2B1/ATP1A4/ATP1B3/ADCY2	1.74395098180534
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/166	63/9376	2.68961560527826	GADD45G/CTNNB1/GADD45B	1.80643879838468
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/166	31/9376	3.64399533618344	ECHS1/ALDH7A1	1.97952844120486
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/166	65/9376	2.60685820203893	LPIN2/PLPP3/ALDH7A1	1.74520294046473
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	6/166	184/9376	1.84180199057098	PLCG2/EPHB4/PLXNB2/SEMA3F/HRAS/NRP1	1.54818807927187
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	7/166	227/9376	1.74173345363834	CTNNB1/ITGAV/AKAP13/GNA12/ADCY2/MDM2/HRAS	1.51874146011161
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/166	32/9376	3.53012048192771	ACSS1/ECHS1	1.9246849206518
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/166	104/9376	2.17238183503244	PISD/LPIN2/PLPP3/LPCAT3	1.61401997836014
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/166	105/9376	2.1516924842226	GADD45G/PLCG2/CFLAR/GADD45B	1.59322737106459
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/166	105/9376	2.1516924842226	UBB/TFEB/HRAS/RPS27A	1.59322737106459
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/166	106/9376	2.13139349852239	CTNNB1/GSTP1/MDM2/HRAS	1.5726664118026
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/166	148/9376	1.90817323347444	GADD45G/CTNNB1/GADD45B/LRP5/HRAS	1.49504969844152
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/166	149/9376	1.89536670170615	PLCG2/GNA12/ADCY2/PLPP3/HRAS	1.47901875144842
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/166	37/9376	3.0530771735591	GLUL/CPS1	1.67983186776954
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/166	38/9376	2.97273303741281	PNP/QPRT	1.63584838062344
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/166	38/9376	2.97273303741281	ATP1A4/ATP1B3	1.63584838062344
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	6/166	201/9376	1.686027692861	GADD45G/ASPSCR1/MLLT1/MDM2/GADD45B/CCND2	1.31991664789714
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/166	75/9376	2.25927710843373	GLUL/CPS1/TKT	1.46993112283062
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/166	158/9376	1.7874027756596	PRR5/LPIN2/SLC38A9/LRP5/HRAS	1.34003764849803
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/166	204/9376	1.66123316796598	CD44/CTNNB1/PLCG2/ITGAV/MDM2/HRAS	1.28188054932084
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/166	41/9376	2.7552159858948	MDM2/HRAS	1.51208150022298
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/166	42/9376	2.68961560527826	ECHS1/ALDH7A1	1.47329096677486
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/166	42/9376	2.68961560527826	GPX4/LPCAT3	1.47329096677486
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	6/166	212/9376	1.59854512389179	PGF/CTNNB1/ADCY2/ID1/HRAS/VASP	1.18340160635931
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/166	43/9376	2.62706640515551	ECHS1/ALDH7A1	1.43561748805079
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/166	82/9376	2.0664119894211	NFYB/HSPA8/HLA-DPB1	1.30208842534884
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/166	168/9376	1.68100975329891	GLUL/CFLAR/HMGB1/SLC25A6/PPIA	1.19573566900425
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	5/166	169/9376	1.67106295002495	UBB/CFLAR/HMGB1/HRAS/RPS27A	1.18183652963458
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/166	44/9376	2.56736035049288	HSPD1/HLA-DPB1	1.39899994213668
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/166	86/9376	1.97029980386663	CTNNB1/ITGB4/ITGAV	1.21354861611793
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/166	47/9376	2.4034862855678	ACSS1/ALDH7A1	1.29493933374537
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/166	178/9376	1.58657100311358	CTNNB1/SERPINF1/LRP5/ZNRF3/CCND2	1.06070289863283
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/166	48/9376	2.35341365461847	ECHS1/ALDH7A1	1.26202154997022
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/166	48/9376	2.35341365461847	ATP1A4/ATP1B3	1.26202154997022
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/166	89/9376	1.90388520373629	ADCY2/TUBB4B/HRAS	1.15021870238401
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/166	89/9376	1.90388520373629	SLC38A1/ADCY2/GLUL	1.15021870238401
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/166	232/9376	1.46073950976319	ITGB4/ITGAV/GNA12/MYH10/HRAS/DIAPH2	0.953984254522003
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/166	139/9376	1.62537921470053	ADCY2/HSPA8/HRAS/KRT23	0.997229777689554
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	8/166	333/9376	1.35692318824849	LAMC2/CTNNB1/ITGB4/ITGAV/MDM2/HRAS/CCND2/TBPL1	0.890328923356623
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	3/166	98/9376	1.72903860339316	PLCG2/PLPP3/VASP	0.973971493888269
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/166	144/9376	1.56894243641232	CTNNB1/DUSP9/ID1/HRAS	0.923658738838126
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/166	99/9376	1.71157356699525	ADCY2/MDM2/HRAS	0.95552816545915
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/166	100/9376	1.6944578313253	CD44/CD24/HLA-DPB1	0.937293007152894
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/166	56/9376	2.01721170395869	HSPD1/HSPA8	1.02496084007415
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/166	101/9376	1.67768102111416	CTNNB1/ADCY2/HRAS	0.91926117481632
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/166	196/9376	1.44086550282764	UBB/CTNNB1/PLCG2/HRAS/RPS27A	0.83738018389694
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/166	18/9376	3.13788487282463	FUCA1	1.21881815191941
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/166	18/9376	3.13788487282463	PRDX1	1.21881815191941
NA	NA	hsa04517	IgSF CAM signaling	7/166	299/9376	1.32231937784583	CTNNB1/PLCG2/MYH10/TUBB4B/NRP2/EPB41L3/NRP1	0.760432569720164
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/166	59/9376	1.91464161731672	ADCY2/PDE3B	0.946125578137745
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	7/166	300/9376	1.31791164658635	GADD45G/PGF/DUSP9/GNA12/HSPA8/GADD45B/HRAS	0.751328199243259
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/166	105/9376	1.61376936316695	PLCG2/MDM2/HRAS	0.849075740542443
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/166	105/9376	1.61376936316695	ITGB4/ITGAV/ADCY2	0.849075740542443
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/166	60/9376	1.88273092369478	PLCG2/HRAS	0.920871629664269
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/166	60/9376	1.88273092369478	GNA12/HRAS	0.920871629664269
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/166	154/9376	1.4670630574245	ATP2B1/ATP1A4/ATP1B3/ADCY2	0.784572689474759
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	6/166	253/9376	1.33949235677889	CD44/UBB/PLCG2/MDM2/RPS27A/FOXO4	0.73490515108262
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/166	254/9376	1.33421876482307	ATP2B1/PLCG2/ADCY2/TFEB/MCOLN3/SLC25A6	0.724957456841666
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/166	155/9376	1.45759813447338	ITGAV/OLR1/TUBB4B/HLA-DPB1	0.771206977973465
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/166	205/9376	1.3776079929474	MDM2/PMAIP1/HRAS/CCND2/TBPL1	0.733870836510579
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	4/166	157/9376	1.43903000537181	BSG/ITGAV/SIRPA/CD24	0.744752532720411
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/166	63/9376	1.7930770701855	ECHS1/ALDH7A1	0.84791190683659
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/166	63/9376	1.7930770701855	GPX4/PTGES	0.84791190683659
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/166	112/9376	1.51290877796902	LAMC2/HSPA8/HLA-DPB1	0.733094121382752
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/166	65/9376	1.73790546802595	KCNN4/HRAS	0.80143648702158
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/166	22/9376	2.56736035049288	ALDH7A1	0.988078344298461
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/166	67/9376	1.686027692861	ACSS1/ALDH7A1	0.756549590499032
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/166	23/9376	2.45573598742797	ENPEP	0.93838473928132
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/166	116/9376	1.46073950976319	CTNNB1/PLCG2/VASP	0.670330259292842
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/166	116/9376	1.46073950976319	SLC38A1/ADCY2/GLUL	0.670330259292842
NA	NA	hsa04382	Cornified envelope formation	5/166	217/9376	1.3014269057798	LAMC2/ITGB4/KRT7/S100A10/KRT23	0.603111653292338
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/166	217/9376	1.3014269057798	MGST3/GSTA3/ADCY2/GSTO1/HRAS	0.603111653292338
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/166	69/9376	1.63715732495198	PLCG2/HRAS	0.713142363084398
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/166	323/9376	1.22406654481704	CD44/PLCG2/ABCB1/MDM2/DNMT1/HRAS/CCND2	0.550163640777255
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/166	70/9376	1.61376936316695	HRAS/EGLN2	0.691962516577136
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/166	170/9376	1.32898653437279	AMOT/MYH10/VASP/RAP2C	0.581134909583935
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/166	71/9376	1.59104021720686	HRAS/CCND2	0.671116453091563
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/166	122/9376	1.38889986174205	PLCG2/ADCY2/HRAS	0.58044733775672
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	5/166	226/9376	1.24960017059388	ATP2B1/ATP1A4/ATP1B3/ADCY2/PDE3B	0.509915739518582
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/166	73/9376	1.54745007426968	MLLT1/PPIA	0.630382728602552
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/166	26/9376	2.17238183503244	SLC19A3	0.803636801533582
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	3/166	125/9376	1.35556626506024	ORMDL1/GNA12/HRAS	0.537268134210425
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/166	27/9376	2.09192324854975	ECHS1	0.762783485960776
Organismal Systems	Immune system	hsa04611	Platelet activation	3/166	126/9376	1.34480780263913	PLCG2/ADCY2/VASP	0.523120040771822
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/166	76/9376	1.4863665187064	OLR1/SLC27A2	0.571529773466296
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/166	28/9376	2.01721170395869	ECHS1	0.723670516986854
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/166	128/9376	1.32379518072289	PNP/ADCY2/PDE3B	0.495177977826346
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/166	77/9376	1.4670630574245	GADD45G/GADD45B	0.5524749913371
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/166	78/9376	1.44825455668829	PLCG2/ISYNA1	0.533687597912819
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/166	78/9376	1.44825455668829	HSPD1/BTG3	0.533687597912819
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/166	78/9376	1.44825455668829	CTNNB1/CLTA	0.533687597912819
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/166	29/9376	1.94765267968425	FRMD6	0.686154537622838
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/166	79/9376	1.42992222052768	AP2S1/CLTA	0.515159709339929
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/166	80/9376	1.41204819277108	PLCG2/HRAS	0.496883776186599
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/166	134/9376	1.26452076964575	GNA12/ADCY2/MYH10	0.41403691297635
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/166	31/9376	1.82199766809172	TKT	0.615420057790427
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/166	31/9376	1.82199766809172	ALDH7A1	0.615420057790427
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/166	32/9376	1.76506024096386	PMAIP1	0.58198805933995
Human Diseases	Immune disease	hsa05310	Asthma	1/166	32/9376	1.76506024096386	HLA-DPB1	0.58198805933995
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/166	86/9376	1.31353320257775	PLCG2/HRAS	0.392134248176716
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/166	140/9376	1.21032702237522	ADCY2/PDE3B/HRAS	0.336609986447892
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	5/166	250/9376	1.12963855421687	AP2S1/HSPA8/MDM2/CLTA/HRAS	0.27891625042742
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/166	362/9376	1.09219197230913	LAMC2/PGF/ITGB4/ITGAV/MDM2/HRAS/CCND2	0.240158787175007
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/166	142/9376	1.19328016290514	UBB/MDM2/RPS27A	0.311563366043793
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/166	144/9376	1.17670682730924	CTNNB1/LPIN2/ALDH7A1	0.286877537709724
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/166	36/9376	1.56894243641232	GALNT11	0.459151500184953
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/166	90/9376	1.25515394912985	ADCY2/HRAS	0.326526983793623
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/166	91/9376	1.24136104858996	PLCG2/HRAS	0.310603820394391
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/166	91/9376	1.24136104858996	ADCY2/PDE3B	0.310603820394391
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/166	37/9376	1.52653858677955	COMT	0.430814929450174
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/166	93/9376	1.21466511206115	ADCY2/HRAS	0.279298519534411
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/166	39/9376	1.44825455668829	HLA-DPB1	0.376585162068829
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	3/166	156/9376	1.08619091751622	CTNNB1/CFLAR/HRAS	0.145736457826148
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/166	99/9376	1.1410490446635	PLCG2/ADCY2	0.189406044769481
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/166	99/9376	1.1410490446635	HLA-DPB1/KRT23	0.189406044769481
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/166	99/9376	1.1410490446635	PLPP3/HRAS	0.189406044769481
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/166	99/9376	1.1410490446635	ITGB4/ITGAV	0.189406044769481
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	4/166	216/9376	1.04596162427488	HSPD1/OLR1/HSPA8/HRAS	0.0917454159594537
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/166	43/9376	1.31353320257775	PLPP3	0.276641289672607
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/166	101/9376	1.11845401407611	PLCG2/HRAS	0.160680575003099
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/166	44/9376	1.28368017524644	TBPL1	0.253208235509014
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/166	44/9376	1.28368017524644	HMGB1	0.253208235509014
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/166	103/9376	1.09673646040473	LAMC2/PRDX1	0.132528274043178
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/166	45/9376	1.25515394912985	ABCB1	0.230332023940635
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/166	45/9376	1.25515394912985	HLA-DPB1	0.230332023940635
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/166	107/9376	1.05573696655782	ADCY2/PDE3B	0.0778446273114641
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	2/166	110/9376	1.02694414019715	PLCG2/EGLN2	0.0381614081157156
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/166	110/9376	1.02694414019715	FBN1/ID1	0.0381614081157156
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/166	110/9376	1.02694414019715	ADCY2/PDE3B	0.0381614081157156
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/166	49/9376	1.15269240226211	GALNT11	0.143864733824841
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/166	50/9376	1.12963855421687	HLA-DPB1	0.12339039164191
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/166	51/9376	1.10748877864399	PLPP3	0.103331721106191
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/166	51/9376	1.10748877864399	PLCG2	0.103331721106191
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/166	174/9376	0.973826339842127	RRBP1/ERP29/HSPA8	-0.0467851295050444
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/166	52/9376	1.08619091751622	ADCY2	0.0836704125573333
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/166	52/9376	1.08619091751622	LRPAP1	0.0836704125573333
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/166	115/9376	0.982294394971189	ADCY2/HRAS	-0.0256472388927242
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/166	238/9376	0.949276095980561	PGF/PLCG2/HRAS/FOXO4	-0.10641073449248
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/166	54/9376	1.04596162427488	DNMT1	0.0454723674736695
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/166	54/9376	1.04596162427488	HLA-DPB1	0.0454723674736695
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/166	181/9376	0.936164547693537	NFYB/HSPD1/HLA-DPB1	-0.116422046104855
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/166	55/9376	1.02694414019715	PLPP3	0.0269044604779018
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/166	120/9376	0.941365461847389	PLCG2/HRAS	-0.0867845320119382
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/166	56/9376	1.00860585197935	CCND2	0.00867141150654953
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/166	57/9376	0.990911012470936	ECHS1	-0.00924013138808204
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	4/166	248/9376	0.910998834045861	CTNNB1/TUBB4B/HRAS/S100A10	-0.190696880160686
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/166	193/9376	0.877957425557151	PLCG2/ADCY2/HRAS	-0.229989277970892
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/166	130/9376	0.868952734012975	ADCY2/HRAS	-0.20199125312718
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/166	195/9376	0.868952734012975	PLCG2/HMGB1/SLC25A6	-0.248261939484605
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/166	133/9376	0.84935229640366	PLCG2/HRAS	-0.234904711188309
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/166	65/9376	0.868952734012975	ADCY2	-0.142329966421567
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	3/166	200/9376	0.847228915662651	GNA12/MYH10/TUBB4B	-0.293183364017941
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/166	66/9376	0.855786783497627	COMT	-0.157838177551428
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/166	66/9376	0.855786783497627	HLA-DPB1	-0.157838177551428
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/166	136/9376	0.830616583982991	HSPA8/CCND2	-0.267124807922391
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/166	67/9376	0.843013846430498	HRAS	-0.173123929883527
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/166	68/9376	0.830616583982991	HRAS	-0.188194541763375
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/166	138/9376	0.818578662475991	PDE3B/HRAS	-0.288236380680639
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/166	69/9376	0.818578662475991	PDE3B	-0.203056978691337
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/166	70/9376	0.806884681583477	HLA-DPB1	-0.217717875378448
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/166	71/9376	0.795520108603428	PLCG2	-0.232183556122691
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/166	71/9376	0.795520108603428	HRAS	-0.232183556122691
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/166	142/9376	0.795520108603428	PLCG2/SIRPA	-0.329617081723241
NA	NA	hsa04519	Cadherin signaling	6/166	404/9376	0.83884051055708	CTNNB1/KRT7/LRP5/HRAS/VASP/KRT23	-0.444540977447307
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/166	144/9376	0.784471218206158	TBPL1/SLC25A6	-0.349903663418678
NA	NA	hsa04081	Hormone signaling	3/166	219/9376	0.773725037134841	ITGAV/GNA12/ADCY2	-0.454874739354163
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/166	78/9376	0.724127278344146	HLA-DPB1	-0.328451430004237
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/166	154/9376	0.733531528712252	QPRT/PDXK	-0.447613832554611
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/166	154/9376	0.733531528712252	ADCY2/HRAS	-0.447613832554611
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/166	155/9376	0.728799067236689	CTNNB1/ADCY2	-0.457064913563686
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	2/166	160/9376	0.706024096385542	ITGAV/HLA-DPB1	-0.503512619100729
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/166	85/9376	0.664493267186393	PNP	-0.417147206672222
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/166	88/9376	0.64184008762322	F5	-0.45317618073023
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/166	90/9376	0.627576974564926	HRAS	-0.47659919670192
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/166	168/9376	0.672403901319564	HRAS/CCND2	-0.575202246841978
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/166	93/9376	0.607332556030574	CTNNB1	-0.510895481417502
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/166	93/9376	0.607332556030574	HLA-DPB1	-0.510895481417502
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/166	173/9376	0.652970262553103	HLA-DPB1/SLC25A6	-0.618493157534611
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/166	95/9376	0.594546607482562	HLA-DPB1	-0.533230794157365
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/166	97/9376	0.582287914544777	ADCY2	-0.555165139407934
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/166	98/9376	0.576346201131055	PLCG2	-0.565987481945864
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/166	103/9376	0.548368230202363	CFLAR	-0.618732365272928
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/166	109/9376	0.51818282303526	HLA-DPB1	-0.6792596441839
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/166	109/9376	0.51818282303526	SLC27A2	-0.6792596441839
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/166	194/9376	0.582287914544777	MYH10/TUBB4B	-0.789258246982875
NA	NA	hsa04082	Neuroactive ligand signaling	2/166	199/9376	0.567657564933099	ADCY2/OGFRL1	-0.827587464491043
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/166	115/9376	0.491147197485595	HRAS	-0.737092540248291
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/166	119/9376	0.47463804799028	CFLAR	-0.774295674032156
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/166	122/9376	0.462966620580683	HRAS	-0.801542057572637
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	2/166	214/9376	0.52786848327891	PLCG2/HRAS	-0.937960614346342
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/166	133/9376	0.42467614820183	COMT	-0.897101515788908
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/166	138/9376	0.409289331237995	ADCY2	-0.938502094169972
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/166	143/9376	0.394978515460443	HLA-DPB1	-0.978762372405543
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/166	163/9376	0.346514893931554	HRAS	-1.12989692711819
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/166	180/9376	0.313788487282463	HLA-DPB1	-1.24797141654267
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/166	191/9376	0.295716899009651	HRAS	-1.32018331057289
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/166	243/9376	0.232435916505528	HSPA8	-1.62749970965414
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/166	298/9376	0.189536670170615	IL1RL1	-1.90878177417495
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/166	370/9376	0.152653858677955	OGFRL1	-2.23257272090095