ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 17/275 175/18639 0.0971428571428571 6.58416623376623 9.61853356768157e-10 6.22319121828997e-07 GO:0016209 antioxidant activity 11/275 86/18639 0.127906976744186 8.66930232558139 5.42830446049363e-08 1.75605649296969e-05 GO:0022853 active monoatomic ion transmembrane transporter activity 12/275 118/18639 0.101694915254237 6.89269645608629 1.78213494704625e-07 3.84347103579642e-05 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 9/275 68/18639 0.132352941176471 8.97064171122995 6.69432931299418e-07 0.000108280776637681 GO:0015399 primary active transmembrane transporter activity 13/275 166/18639 0.0783132530120482 5.30792990142388 1.14364133328504e-06 0.000118397316630832 GO:0009055 electron transfer activity 11/275 116/18639 0.0948275862068965 6.42724137931034 1.18032592472982e-06 0.000118397316630832 GO:0022804 active transmembrane transporter activity 22/275 457/18639 0.0481400437636762 3.26284463894967 1.28096014901982e-06 0.000118397316630832 GO:0004601 peroxidase activity 8/275 57/18639 0.140350877192982 9.51272727272727 1.79219026038533e-06 0.000144943387308663 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 8/275 59/18639 0.135593220338983 9.19026194144838 2.34453169533926e-06 0.000168545778542722 GO:0004602 glutathione peroxidase activity 5/275 23/18639 0.217391304347826 14.7343873517787 1.82457011805393e-05 0.00118049686638089 GO:0015078 proton transmembrane transporter activity 12/275 185/18639 0.0648648648648649 4.3964226044226 2.03136766932307e-05 0.0011948135291382 GO:0004364 glutathione transferase activity 5/275 27/18639 0.185185185185185 12.5515151515152 4.1710844191226e-05 0.0022489096826436 GO:0019843 rRNA binding 7/275 65/18639 0.107692307692308 7.29918881118881 4.72740549234686e-05 0.0023527933488834 GO:1901681 sulfur compound binding 14/275 275/18639 0.0509090909090909 3.45052561983471 6.25431977892421e-05 0.00289038921211712 GO:0046943 carboxylic acid transmembrane transporter activity 11/275 188/18639 0.0585106382978723 3.96574468085106 0.000113771977491448 0.00482218329958504 GO:0005342 organic acid transmembrane transporter activity 11/275 189/18639 0.0582010582010582 3.94476190476191 0.000119250282524514 0.00482218329958504 GO:0008514 organic anion transmembrane transporter activity 13/275 269/18639 0.0483271375464684 3.27552551537682 0.000190935848183107 0.00726679375143943 GO:0008201 heparin binding 10/275 172/18639 0.0581395348837209 3.94059196617336 0.000244148710507697 0.00877578976102668 GO:0005539 glycosaminoglycan binding 12/275 242/18639 0.0495867768595041 3.36090157776108 0.000265247666366822 0.00903238105996495 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/275 41/18639 0.121951219512195 8.26563192904656 0.000327140776060797 0.0105830041055668 GO:0048027 mRNA 5'-UTR binding 4/275 24/18639 0.166666666666667 11.2963636363636 0.000390328867522332 0.0120258465374738 GO:0003954 NADH dehydrogenase activity 5/275 44/18639 0.113636363636364 7.70206611570248 0.00045731593940895 0.0129018294027567 GO:0050840 extracellular matrix binding 6/275 67/18639 0.0895522388059701 6.06968792401628 0.000458643085414843 0.0129018294027567 GO:0017154 semaphorin receptor activity 3/275 13/18639 0.230769230769231 15.6411188811189 0.000814259972896301 0.0204890292580555 GO:0061459 L-arginine transmembrane transporter activity 3/275 13/18639 0.230769230769231 15.6411188811189 0.000814259972896301 0.0204890292580555 GO:0043236 laminin binding 4/275 29/18639 0.137931034482759 9.34871473354232 0.000823361299396359 0.0204890292580555 GO:0015101 organic cation transmembrane transporter activity 6/275 81/18639 0.0740740740740741 5.02060606060606 0.0012564528270094 0.0292863547960413 GO:0004129 cytochrome-c oxidase activity 3/275 15/18639 0.2 13.5556363636364 0.0012674156635072 0.0292863547960413 GO:0016675 oxidoreductase activity, acting on a heme group of donors 3/275 16/18639 0.1875 12.7084090909091 0.00154296534701928 0.0344240889490164 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 5/275 58/18639 0.0862068965517241 5.84294670846395 0.00163186927544234 0.0351939807070398 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/275 61/18639 0.0819672131147541 5.55558867362146 0.00204422719349406 0.0426649998126019 GO:0005507 copper ion binding 5/275 63/18639 0.0793650793650794 5.37922077922078 0.00235833129999522 0.0476825109717784 GO:0015174 basic amino acid transmembrane transporter activity 3/275 21/18639 0.142857142857143 9.6825974025974 0.00347035691942283 0.0680400280868659 GO:0015662 P-type ion transporter activity 3/275 25/18639 0.12 8.13338181818182 0.00574641234440477 0.106226536766568 GO:0140358 P-type transmembrane transporter activity 3/275 25/18639 0.12 8.13338181818182 0.00574641234440477 0.106226536766568 GO:0031406 carboxylic acid binding 8/275 187/18639 0.0427807486631016 2.89960136120564 0.00670225676129611 0.117610462210568 GO:0016597 amino acid binding 4/275 51/18639 0.0784313725490196 5.315935828877 0.0067257915019954 0.117610462210568 GO:0043177 organic acid binding 8/275 189/18639 0.0423280423280423 2.86891774891775 0.00712948601708104 0.121388880343459 GO:0019902 phosphatase binding 8/275 190/18639 0.0421052631578947 2.85381818181818 0.00735066065400707 0.121945575465194 GO:0051082 unfolded protein binding 6/275 121/18639 0.0495867768595041 3.36090157776108 0.00914923261182958 0.147988837496343 GO:0016651 oxidoreductase activity, acting on NAD(P)H 5/275 88/18639 0.0568181818181818 3.85103305785124 0.00977181465172931 0.154204001943143 GO:0008432 JUN kinase binding 2/275 11/18639 0.181818181818182 12.323305785124 0.0109257500671668 0.16439442542923 GO:0097493 structural molecule activity conferring elasticity 2/275 11/18639 0.181818181818182 12.323305785124 0.0109257500671668 0.16439442542923 GO:0004714 transmembrane receptor protein tyrosine kinase activity 4/275 60/18639 0.0666666666666667 4.51854545454545 0.0118429302735103 0.174144906521844 GO:0005201 extracellular matrix structural constituent 7/275 168/18639 0.0416666666666667 2.82409090909091 0.0124918825185454 0.179605510877753 GO:0005078 MAP-kinase scaffold activity 2/275 12/18639 0.166666666666667 11.2963636363636 0.0129842517228055 0.1823053892136 GO:0015179 L-amino acid transmembrane transporter activity 4/275 62/18639 0.0645161290322581 4.37278592375367 0.0132432044714671 0.1823053892136 GO:0051087 protein-folding chaperone binding 6/275 134/18639 0.0447761194029851 3.03484396200814 0.0146079625953239 0.192793028227432 GO:0030955 potassium ion binding 2/275 13/18639 0.153846153846154 10.4274125874126 0.0151969774955163 0.192793028227432 GO:0031994 insulin-like growth factor I binding 2/275 13/18639 0.153846153846154 10.4274125874126 0.0151969774955163 0.192793028227432 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/275 13/18639 0.153846153846154 10.4274125874126 0.0151969774955163 0.192793028227432 GO:0008195 phosphatidate phosphatase activity 2/275 14/18639 0.142857142857143 9.6825974025974 0.0175589626658216 0.218474016245895 GO:0061134 peptidase regulator activity 8/275 226/18639 0.0353982300884956 2.39922767497989 0.0192959521569532 0.228270975785863 GO:0061135 endopeptidase regulator activity 7/275 184/18639 0.0380434782608696 2.57851778656127 0.0196348896488947 0.228270975785863 GO:0031386 protein tag activity 2/275 15/18639 0.133333333333333 9.03709090909091 0.0200653545123315 0.228270975785863 GO:0141047 molecular tag activity 2/275 15/18639 0.133333333333333 9.03709090909091 0.0200653545123315 0.228270975785863 GO:0019903 protein phosphatase binding 6/275 144/18639 0.0416666666666667 2.82409090909091 0.0201104259965907 0.228270975785863 GO:0004857 enzyme inhibitor activity 12/275 416/18639 0.0288461538461538 1.95513986013986 0.0211421757407693 0.235844615590996 GO:0005518 collagen binding 4/275 72/18639 0.0555555555555556 3.76545454545455 0.0218044356922519 0.239109659201474 GO:0042056 chemoattractant activity 3/275 42/18639 0.0714285714285714 4.8412987012987 0.0238848337339546 0.257558123764477 GO:0005092 GDP-dissociation inhibitor activity 2/275 17/18639 0.117647058823529 7.97390374331551 0.0254924941529294 0.270387601917137 GO:0098631 cell adhesion mediator activity 4/275 76/18639 0.0526315789473684 3.56727272727273 0.0259901411874217 0.271219699165514 GO:0030547 signaling receptor inhibitor activity 3/275 44/18639 0.0681818181818182 4.62123966942149 0.026972257279955 0.273986656284048 GO:0015291 secondary active transmembrane transporter activity 9/275 287/18639 0.0313588850174216 2.12544821032626 0.0271022349338162 0.273986656284048 GO:0019199 transmembrane receptor protein kinase activity 4/275 78/18639 0.0512820512820513 3.4758041958042 0.0282515492133799 0.281211574477797 GO:0016829 lyase activity 7/275 200/18639 0.035 2.37223636363636 0.0292375857954535 0.286616939540279 GO:0030291 protein serine/threonine kinase inhibitor activity 3/275 46/18639 0.0652173913043478 4.4203162055336 0.0302623432022574 0.287323568445993 GO:0005520 insulin-like growth factor binding 2/275 19/18639 0.105263157894737 7.13454545454545 0.0314417318436506 0.287323568445993 GO:0031420 alkali metal ion binding 2/275 19/18639 0.105263157894737 7.13454545454545 0.0314417318436506 0.287323568445993 GO:0042577 lipid phosphatase activity 2/275 19/18639 0.105263157894737 7.13454545454545 0.0314417318436506 0.287323568445993 GO:0043495 protein-membrane adaptor activity 3/275 47/18639 0.0638297872340425 4.3262669245648 0.0319830342958425 0.287323568445993 GO:0004866 endopeptidase inhibitor activity 6/275 161/18639 0.0372670807453416 2.52589497459063 0.0324182697010162 0.287323568445993 GO:0005178 integrin binding 6/275 161/18639 0.0372670807453416 2.52589497459063 0.0324182697010162 0.287323568445993 GO:0001540 amyloid-beta binding 4/275 83/18639 0.0481927710843374 3.26641840087623 0.0344037259319908 0.300800144297271 GO:0016763 pentosyltransferase activity 3/275 49/18639 0.0612244897959184 4.14968460111317 0.0355747407444547 0.304763884319241 GO:0031625 ubiquitin protein ligase binding 9/275 302/18639 0.0298013245033113 2.01987959060807 0.0357991579725847 0.304763884319241 GO:0016874 ligase activity 6/275 167/18639 0.0359281437125748 2.43514425694066 0.0377205740451736 0.316950797496459 GO:0005021 vascular endothelial growth factor receptor activity 3/275 51/18639 0.0588235294117647 3.98695187165775 0.0393652484485203 0.32435177212253 GO:0030414 peptidase inhibitor activity 6/275 169/18639 0.0355029585798817 2.4063259817106 0.0396040030876041 0.32435177212253 GO:0003925 G protein activity 3/275 54/18639 0.0555555555555556 3.76545454545455 0.0454185601555692 0.360930951341187 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/275 54/18639 0.0555555555555556 3.76545454545455 0.0454185601555692 0.360930951341187 GO:0072341 modified amino acid binding 4/275 91/18639 0.043956043956044 2.97926073926074 0.0457439536475693 0.360930951341187 GO:0098632 cell-cell adhesion mediator activity 3/275 55/18639 0.0545454545454545 3.69699173553719 0.0475329611295464 0.370528022298994 GO:0015295 solute:proton symporter activity 2/275 24/18639 0.0833333333333333 5.64818181818182 0.048373152512617 0.3725884485198 GO:0044389 ubiquitin-like protein ligase binding 9/275 322/18639 0.0279503105590062 1.89442123094297 0.0501379990056193 0.381638651254538 GO:0015645 fatty acid ligase activity 2/275 25/18639 0.08 5.42225454545455 0.0520798255707224 0.383097854538901 GO:0120515 fatty acid-CoA ligase activity 2/275 25/18639 0.08 5.42225454545455 0.0520798255707224 0.383097854538901 GO:0004867 serine-type endopeptidase inhibitor activity 4/275 95/18639 0.0421052631578947 2.85381818181818 0.0521060451304842 0.383097854538901 GO:0008198 ferrous iron binding 2/275 26/18639 0.0769230769230769 5.21370629370629 0.0558843147186034 0.401746129143738 GO:0070006 metalloaminopeptidase activity 2/275 26/18639 0.0769230769230769 5.21370629370629 0.0558843147186034 0.401746129143738 GO:0042626 ATPase-coupled transmembrane transporter activity 4/275 98/18639 0.0408163265306122 2.76645640074211 0.05717825316449 0.406531096675 GO:0016405 CoA-ligase activity 2/275 27/18639 0.0740740740740741 5.02060606060606 0.0597829503072256 0.415327378775794 GO:0023026 MHC class II protein complex binding 2/275 27/18639 0.0740740740740741 5.02060606060606 0.0597829503072256 0.415327378775794 GO:0045296 cadherin binding 9/275 334/18639 0.0269461077844311 1.8263581927055 0.0603412265918465 0.415327378775794 GO:0015026 coreceptor activity 3/275 61/18639 0.0491803278688525 3.33335320417288 0.0612053223335243 0.416840458418844 GO:0019955 cytokine binding 5/275 144/18639 0.0347222222222222 2.35340909090909 0.0624415342608404 0.420829923612122 GO:0097718 disordered domain specific binding 2/275 28/18639 0.0714285714285714 4.8412987012987 0.0637721489789118 0.424760803521605 GO:0015171 amino acid transmembrane transporter activity 4/275 102/18639 0.0392156862745098 2.6579679144385 0.0643378033154827 0.424760803521605 GO:1901682 sulfur compound transmembrane transporter activity 3/275 63/18639 0.0476190476190476 3.22753246753247 0.0661272196949523 0.432164759016507 GO:0048019 receptor antagonist activity 2/275 30/18639 0.0666666666666667 4.51854545454545 0.0720083232368829 0.465893851342632 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/275 31/18639 0.0645161290322581 4.37278592375367 0.0762485481351353 0.467930157519212 GO:0005452 solute:inorganic anion antiporter activity 2/275 31/18639 0.0645161290322581 4.37278592375367 0.0762485481351353 0.467930157519212 GO:0016878 acid-thiol ligase activity 2/275 31/18639 0.0645161290322581 4.37278592375367 0.0762485481351353 0.467930157519212 GO:0017147 Wnt-protein binding 2/275 31/18639 0.0645161290322581 4.37278592375367 0.0762485481351353 0.467930157519212 GO:0072349 modified amino acid transmembrane transporter activity 2/275 31/18639 0.0645161290322581 4.37278592375367 0.0762485481351353 0.467930157519212 GO:0042277 peptide binding 7/275 249/18639 0.0281124497991968 1.90541073384447 0.0766624369351414 0.467930157519212 GO:0015106 bicarbonate transmembrane transporter activity 2/275 32/18639 0.0625 4.23613636363636 0.0805658314340625 0.487159747082602 GO:0019956 chemokine binding 2/275 33/18639 0.0606060606060606 4.10776859504132 0.0849569958832399 0.508955336448668 GO:0003713 transcription coactivator activity 7/275 256/18639 0.02734375 1.85330965909091 0.0858105003519832 0.509352236034249 GO:0015294 solute:monoatomic cation symporter activity 4/275 116/18639 0.0344827586206897 2.33717868338558 0.0928491006721106 0.546121528498687 GO:0005343 organic acid:sodium symporter activity 2/275 35/18639 0.0571428571428571 3.87303896103896 0.0939486395224389 0.546219429842284 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/275 36/18639 0.0555555555555556 3.76545454545455 0.0985431398876352 0.546219429842284 GO:0044183 protein folding chaperone 3/275 75/18639 0.04 2.71112727272727 0.0991828129602121 0.546219429842284 GO:0016757 glycosyltransferase activity 7/275 267/18639 0.0262172284644195 1.77695607763024 0.101389212979906 0.546219429842284 GO:0023023 MHC protein complex binding 2/275 37/18639 0.0540540540540541 3.6636855036855 0.103199560742929 0.546219429842284 GO:0042805 actinin binding 2/275 37/18639 0.0540540540540541 3.6636855036855 0.103199560742929 0.546219429842284 GO:0051540 metal cluster binding 3/275 77/18639 0.038961038961039 2.64070838252656 0.105234678443947 0.546219429842284 GO:0042887 amide transmembrane transporter activity 2/275 38/18639 0.0526315789473684 3.56727272727273 0.107915091481405 0.546219429842284 GO:0003712 transcription coregulator activity 11/275 495/18639 0.0222222222222222 1.50618181818182 0.116903192000141 0.546219429842284 GO:0004177 aminopeptidase activity 2/275 40/18639 0.05 3.38890909090909 0.117512583320838 0.546219429842284 GO:0140662 ATP-dependent protein folding chaperone 2/275 40/18639 0.05 3.38890909090909 0.117512583320838 0.546219429842284 GO:0001618 virus receptor activity 3/275 81/18639 0.037037037037037 2.51030303030303 0.11775766763295 0.546219429842284 GO:0140272 exogenous protein binding 3/275 82/18639 0.0365853658536585 2.47968957871397 0.120971909166977 0.546219429842284 GO:0001530 lipopolysaccharide binding 2/275 41/18639 0.0487804878048781 3.30625277161863 0.122389262147259 0.546219429842284 GO:0015175 neutral L-amino acid transmembrane transporter activity 2/275 41/18639 0.0487804878048781 3.30625277161863 0.122389262147259 0.546219429842284 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/275 41/18639 0.0487804878048781 3.30625277161863 0.122389262147259 0.546219429842284 GO:0008135 translation factor activity, RNA binding 3/275 83/18639 0.036144578313253 2.44981380065717 0.124218216038289 0.546219429842284 GO:0000287 magnesium ion binding 6/275 230/18639 0.0260869565217391 1.76812648221344 0.125848730185866 0.546219429842284 GO:0004860 protein kinase inhibitor activity 3/275 84/18639 0.0357142857142857 2.42064935064935 0.127495918243233 0.546219429842284 GO:0180051 translation factor activity 3/275 84/18639 0.0357142857142857 2.42064935064935 0.127495918243233 0.546219429842284 GO:0016853 isomerase activity 5/275 180/18639 0.0277777777777778 1.88272727272727 0.128151129632376 0.546219429842284 GO:0019207 kinase regulator activity 7/275 287/18639 0.024390243902439 1.65312638580931 0.133364454293962 0.546219429842284 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/275 44/18639 0.0454545454545455 3.08082644628099 0.137300696762047 0.546219429842284 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0005522 profilin binding 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0008239 dipeptidyl-peptidase activity 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0015187 glycine transmembrane transporter activity 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0015203 polyamine transmembrane transporter activity 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0015658 branched-chain amino acid transmembrane transporter activity 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0019531 oxalate transmembrane transporter activity 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0019911 structural constituent of myelin sheath 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0031957 very long-chain fatty acid-CoA ligase activity 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0035374 chondroitin sulfate binding 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0042975 peroxisome proliferator activated receptor binding 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0043295 glutathione binding 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0043422 protein kinase B binding 1/275 10/18639 0.1 6.77781818181818 0.138151260489324 0.546219429842284 GO:0015297 antiporter activity 4/275 135/18639 0.0296296296296296 2.00824242424242 0.139373662449157 0.546219429842284 GO:0004197 cysteine-type endopeptidase activity 3/275 88/18639 0.0340909090909091 2.31061983471074 0.140907235448093 0.546219429842284 GO:0002020 protease binding 4/275 136/18639 0.0294117647058824 1.99347593582888 0.142044309713179 0.546219429842284 GO:0019838 growth factor binding 4/275 136/18639 0.0294117647058824 1.99347593582888 0.142044309713179 0.546219429842284 GO:0044325 transmembrane transporter binding 4/275 136/18639 0.0294117647058824 1.99347593582888 0.142044309713179 0.546219429842284 GO:0030276 clathrin binding 2/275 46/18639 0.0434782608695652 2.94687747035573 0.14745212160163 0.546219429842284 GO:0019210 kinase inhibitor activity 3/275 90/18639 0.0333333333333333 2.25927272727273 0.147783770838278 0.546219429842284 GO:0003953 NAD+ nucleosidase activity 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0004016 adenylate cyclase activity 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0008271 secondary active sulfate transmembrane transporter activity 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0015217 ADP transmembrane transporter activity 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0016594 glycine binding 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0032050 clathrin heavy chain binding 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0045294 alpha-catenin binding 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0047676 arachidonate-CoA ligase activity 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0050786 RAGE receptor binding 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0140031 phosphorylation-dependent protein binding 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:1900750 oligopeptide binding 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:1990948 ubiquitin ligase inhibitor activity 1/275 11/18639 0.0909090909090909 6.16165289256198 0.150873811531539 0.546219429842284 GO:0140359 ABC-type transporter activity 2/275 47/18639 0.0425531914893617 2.88417794970986 0.152584081037443 0.546219429842284 GO:0004713 protein tyrosine kinase activity 4/275 140/18639 0.0285714285714286 1.93651948051948 0.152926365481448 0.546219429842284 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/275 48/18639 0.0416666666666667 2.82409090909091 0.157750610295608 0.546219429842284 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2/275 48/18639 0.0416666666666667 2.82409090909091 0.157750610295608 0.546219429842284 GO:0051213 dioxygenase activity 3/275 93/18639 0.032258064516129 2.18639296187683 0.158297027275791 0.546219429842284 GO:0033218 amide binding 6/275 247/18639 0.0242914979757085 1.64643356643357 0.15932049723023 0.546219429842284 GO:0004300 enoyl-CoA hydratase activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0008179 adenylate cyclase binding 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0008603 cAMP-dependent protein kinase regulator activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0015269 calcium-activated potassium channel activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0016208 AMP binding 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0031543 peptidyl-proline dioxygenase activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0042301 phosphate ion binding 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0140900 chloride:bicarbonate antiporter activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/275 12/18639 0.0833333333333333 5.64818181818182 0.163409226059606 0.546219429842284 GO:0005006 epidermal growth factor receptor activity 2/275 50/18639 0.04 2.71112727272727 0.168178929429462 0.546219429842284 GO:0015293 symporter activity 4/275 146/18639 0.0273972602739726 1.85693648816936 0.169814776657537 0.546219429842284 GO:0015085 calcium ion transmembrane transporter activity 4/275 147/18639 0.0272108843537415 1.84430426716141 0.172691540914141 0.546219429842284 GO:0003743 translation initiation factor activity 2/275 51/18639 0.0392156862745098 2.6579679144385 0.17343663069399 0.546219429842284 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/275 13/18639 0.0769230769230769 5.21370629370629 0.175760246773281 0.546219429842284 GO:0005172 vascular endothelial growth factor receptor binding 1/275 13/18639 0.0769230769230769 5.21370629370629 0.175760246773281 0.546219429842284 GO:0008035 high-density lipoprotein particle binding 1/275 13/18639 0.0769230769230769 5.21370629370629 0.175760246773281 0.546219429842284 GO:0035673 oligopeptide transmembrane transporter activity 1/275 13/18639 0.0769230769230769 5.21370629370629 0.175760246773281 0.546219429842284 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 1/275 13/18639 0.0769230769230769 5.21370629370629 0.175760246773281 0.546219429842284 GO:0140333 glycerophospholipid flippase activity 1/275 13/18639 0.0769230769230769 5.21370629370629 0.175760246773281 0.546219429842284 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/275 13/18639 0.0769230769230769 5.21370629370629 0.175760246773281 0.546219429842284 GO:0019887 protein kinase regulator activity 6/275 255/18639 0.0235294117647059 1.5947807486631 0.176287836341111 0.546219429842284 GO:0008509 monoatomic anion transmembrane transporter activity 4/275 149/18639 0.0268456375838926 1.81954850518609 0.178495442663763 0.546219429842284 GO:0005080 protein kinase C binding 2/275 52/18639 0.0384615384615385 2.60685314685315 0.178720722292496 0.546219429842284 GO:0030159 signaling receptor complex adaptor activity 2/275 52/18639 0.0384615384615385 2.60685314685315 0.178720722292496 0.546219429842284 GO:0019842 vitamin binding 4/275 150/18639 0.0266666666666667 1.80741818181818 0.181421953688725 0.546219429842284 GO:0004864 protein phosphatase inhibitor activity 2/275 53/18639 0.0377358490566038 2.55766723842196 0.184029290671853 0.546219429842284 GO:0016860 intramolecular oxidoreductase activity 2/275 53/18639 0.0377358490566038 2.55766723842196 0.184029290671853 0.546219429842284 GO:1901505 carbohydrate derivative transmembrane transporter activity 2/275 53/18639 0.0377358490566038 2.55766723842196 0.184029290671853 0.546219429842284 GO:0030695 GTPase regulator activity 10/275 489/18639 0.0204498977505112 1.38605688789738 0.187903014209261 0.546219429842284 GO:0005347 ATP transmembrane transporter activity 1/275 14/18639 0.0714285714285714 4.8412987012987 0.187929576320008 0.546219429842284 GO:0008559 ABC-type xenobiotic transporter activity 1/275 14/18639 0.0714285714285714 4.8412987012987 0.187929576320008 0.546219429842284 GO:0031404 chloride ion binding 1/275 14/18639 0.0714285714285714 4.8412987012987 0.187929576320008 0.546219429842284 GO:0032036 myosin heavy chain binding 1/275 14/18639 0.0714285714285714 4.8412987012987 0.187929576320008 0.546219429842284 GO:0042813 Wnt receptor activity 1/275 14/18639 0.0714285714285714 4.8412987012987 0.187929576320008 0.546219429842284 GO:0070742 C2H2 zinc finger domain binding 1/275 14/18639 0.0714285714285714 4.8412987012987 0.187929576320008 0.546219429842284 GO:1901474 azole transmembrane transporter activity 1/275 14/18639 0.0714285714285714 4.8412987012987 0.187929576320008 0.546219429842284 GO:0060589 nucleoside-triphosphatase regulator activity 10/275 490/18639 0.0204081632653061 1.38322820037106 0.189502821790676 0.546219429842284 GO:0008238 exopeptidase activity 3/275 102/18639 0.0294117647058824 1.99347593582888 0.191097601590542 0.546219429842284 GO:0005525 GTP binding 8/275 378/18639 0.0211640211640212 1.43445887445887 0.196908964681098 0.546219429842284 GO:0004089 carbonate dehydratase activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0004467 long-chain fatty acid-CoA ligase activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0005041 low-density lipoprotein particle receptor activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0015116 sulfate transmembrane transporter activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0016846 carbon-sulfur lyase activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0031005 filamin binding 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0042809 nuclear vitamin D receptor binding 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0048531 beta-1,3-galactosyltransferase activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0050780 dopamine receptor binding 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0051371 muscle alpha-actinin binding 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0061578 K63-linked deubiquitinase activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0140776 protein-containing complex destabilizing activity 1/275 15/18639 0.0666666666666667 4.51854545454545 0.199919877877699 0.546219429842284 GO:0019212 phosphatase inhibitor activity 2/275 56/18639 0.0357142857142857 2.42064935064935 0.200083469664021 0.546219429842284 GO:0030170 pyridoxal phosphate binding 2/275 56/18639 0.0357142857142857 2.42064935064935 0.200083469664021 0.546219429842284 GO:0016504 peptidase activator activity 2/275 57/18639 0.0350877192982456 2.37818181818182 0.205471800578807 0.547967011586792 GO:0070279 vitamin B6 binding 2/275 57/18639 0.0350877192982456 2.37818181818182 0.205471800578807 0.547967011586792 GO:0008013 beta-catenin binding 3/275 106/18639 0.0283018867924528 1.91825042881647 0.206191791305287 0.547967011586792 GO:0019888 protein phosphatase regulator activity 3/275 107/18639 0.0280373831775701 1.90032285471538 0.210007489850394 0.547967011586792 GO:0015079 potassium ion transmembrane transporter activity 4/275 160/18639 0.025 1.69445454545455 0.21151239493474 0.547967011586792 GO:0003688 DNA replication origin binding 1/275 16/18639 0.0625 4.23613636363636 0.211733775729054 0.547967011586792 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/275 16/18639 0.0625 4.23613636363636 0.211733775729054 0.547967011586792 GO:0015562 efflux transmembrane transporter activity 1/275 16/18639 0.0625 4.23613636363636 0.211733775729054 0.547967011586792 GO:0022858 alanine transmembrane transporter activity 1/275 16/18639 0.0625 4.23613636363636 0.211733775729054 0.547967011586792 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/275 16/18639 0.0625 4.23613636363636 0.211733775729054 0.547967011586792 GO:0070411 I-SMAD binding 1/275 16/18639 0.0625 4.23613636363636 0.211733775729054 0.547967011586792 GO:0140327 flippase activity 1/275 16/18639 0.0625 4.23613636363636 0.211733775729054 0.547967011586792 GO:0140328 floppase activity 1/275 16/18639 0.0625 4.23613636363636 0.211733775729054 0.547967011586792 GO:0001786 phosphatidylserine binding 2/275 59/18639 0.0338983050847458 2.2975654853621 0.216293764854917 0.557227206580182 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 2/275 60/18639 0.0333333333333333 2.25927272727273 0.221724188419148 0.557227206580182 GO:0046873 metal ion transmembrane transporter activity 9/275 450/18639 0.02 1.35556363636364 0.22190896893032 0.557227206580182 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/275 17/18639 0.0588235294117647 3.98695187165775 0.223373855827562 0.557227206580182 GO:0015278 intracellularly gated calcium channel activity 1/275 17/18639 0.0588235294117647 3.98695187165775 0.223373855827562 0.557227206580182 GO:0016018 cyclosporin A binding 1/275 17/18639 0.0588235294117647 3.98695187165775 0.223373855827562 0.557227206580182 GO:0038191 neuropilin binding 1/275 17/18639 0.0588235294117647 3.98695187165775 0.223373855827562 0.557227206580182 GO:0070492 oligosaccharide binding 1/275 17/18639 0.0588235294117647 3.98695187165775 0.223373855827562 0.557227206580182 GO:1990226 histone methyltransferase binding 1/275 17/18639 0.0588235294117647 3.98695187165775 0.223373855827562 0.557227206580182 GO:0015081 sodium ion transmembrane transporter activity 4/275 164/18639 0.024390243902439 1.65312638580931 0.22392437976947 0.557227206580182 GO:0015103 inorganic anion transmembrane transporter activity 4/275 165/18639 0.0242424242424242 1.64310743801653 0.227056971048854 0.560977413458335 GO:0016836 hydro-lyase activity 2/275 61/18639 0.0327868852459016 2.22223546944858 0.227165505913576 0.560977413458335 GO:0000400 four-way junction DNA binding 1/275 18/18639 0.0555555555555556 3.76545454545455 0.234842666355294 0.562752611599537 GO:0003746 translation elongation factor activity 1/275 18/18639 0.0555555555555556 3.76545454545455 0.234842666355294 0.562752611599537 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/275 18/18639 0.0555555555555556 3.76545454545455 0.234842666355294 0.562752611599537 GO:0008525 phosphatidylcholine transporter activity 1/275 18/18639 0.0555555555555556 3.76545454545455 0.234842666355294 0.562752611599537 GO:0030228 lipoprotein particle receptor activity 1/275 18/18639 0.0555555555555556 3.76545454545455 0.234842666355294 0.562752611599537 GO:0034185 apolipoprotein binding 1/275 18/18639 0.0555555555555556 3.76545454545455 0.234842666355294 0.562752611599537 GO:0035615 clathrin adaptor activity 1/275 18/18639 0.0555555555555556 3.76545454545455 0.234842666355294 0.562752611599537 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/275 18/18639 0.0555555555555556 3.76545454545455 0.234842666355294 0.562752611599537 GO:0019001 guanyl nucleotide binding 8/275 400/18639 0.02 1.35556363636364 0.239822264616961 0.570459577967552 GO:0032561 guanyl ribonucleotide binding 8/275 400/18639 0.02 1.35556363636364 0.239822264616961 0.570459577967552 GO:0017124 SH3 domain binding 3/275 115/18639 0.0260869565217391 1.76812648221344 0.241043754521895 0.570804081442211 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/275 19/18639 0.0526315789473684 3.56727272727273 0.246142718272607 0.570804081442211 GO:0005346 purine ribonucleotide transmembrane transporter activity 1/275 19/18639 0.0526315789473684 3.56727272727273 0.246142718272607 0.570804081442211 GO:0008301 DNA binding, bending 1/275 19/18639 0.0526315789473684 3.56727272727273 0.246142718272607 0.570804081442211 GO:0015245 fatty acid transmembrane transporter activity 1/275 19/18639 0.0526315789473684 3.56727272727273 0.246142718272607 0.570804081442211 GO:0046624 sphingolipid transporter activity 1/275 19/18639 0.0526315789473684 3.56727272727273 0.246142718272607 0.570804081442211 GO:1990380 K48-linked deubiquitinase activity 1/275 19/18639 0.0526315789473684 3.56727272727273 0.246142718272607 0.570804081442211 GO:0019208 phosphatase regulator activity 3/275 117/18639 0.0256410256410256 1.7379020979021 0.24892273361778 0.572790183140759 GO:0008235 metalloexopeptidase activity 2/275 66/18639 0.0303030303030303 2.05388429752066 0.254484539986239 0.572790183140759 GO:0001614 purinergic nucleotide receptor activity 1/275 20/18639 0.05 3.38890909090909 0.25727648585988 0.572790183140759 GO:0016004 phospholipase activator activity 1/275 20/18639 0.05 3.38890909090909 0.25727648585988 0.572790183140759 GO:0016502 nucleotide receptor activity 1/275 20/18639 0.05 3.38890909090909 0.25727648585988 0.572790183140759 GO:0016505 peptidase activator activity involved in apoptotic process 1/275 20/18639 0.05 3.38890909090909 0.25727648585988 0.572790183140759 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/275 20/18639 0.05 3.38890909090909 0.25727648585988 0.572790183140759 GO:0031418 L-ascorbic acid binding 1/275 20/18639 0.05 3.38890909090909 0.25727648585988 0.572790183140759 GO:0042288 MHC class I protein binding 1/275 20/18639 0.05 3.38890909090909 0.25727648585988 0.572790183140759 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2/275 67/18639 0.0298507462686567 2.02322930800543 0.259961204900716 0.572790183140759 GO:0015108 chloride transmembrane transporter activity 3/275 121/18639 0.0247933884297521 1.68045078888054 0.26479222725706 0.572790183140759 GO:0030145 manganese ion binding 2/275 68/18639 0.0294117647058824 1.99347593582888 0.265439125324334 0.572790183140759 GO:1990841 promoter-specific chromatin binding 2/275 68/18639 0.0294117647058824 1.99347593582888 0.265439125324334 0.572790183140759 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0001846 opsonin binding 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0005123 death receptor binding 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0008373 sialyltransferase activity 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0009975 cyclase activity 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0035613 RNA stem-loop binding 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0070182 DNA polymerase binding 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0072542 protein phosphatase activator activity 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0140312 cargo adaptor activity 1/275 21/18639 0.0476190476190476 3.22753246753247 0.268246407251391 0.572790183140759 GO:0002039 p53 binding 2/275 69/18639 0.0289855072463768 1.96458498023715 0.270917076565896 0.576589962296495 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/275 70/18639 0.0285714285714286 1.93651948051948 0.27639386954066 0.578057806623792 GO:0005267 potassium channel activity 3/275 124/18639 0.0241935483870968 1.63979472140762 0.276774516816159 0.578057806623792 GO:0008093 cytoskeletal anchor activity 1/275 22/18639 0.0454545454545455 3.08082644628099 0.279054884961449 0.578057806623792 GO:0031683 G-protein beta/gamma-subunit complex binding 1/275 22/18639 0.0454545454545455 3.08082644628099 0.279054884961449 0.578057806623792 GO:0061133 endopeptidase activator activity 1/275 22/18639 0.0454545454545455 3.08082644628099 0.279054884961449 0.578057806623792 GO:0140517 protein-RNA adaptor activity 1/275 22/18639 0.0454545454545455 3.08082644628099 0.279054884961449 0.578057806623792 GO:0140299 molecular sensor activity 2/275 71/18639 0.028169014084507 1.90924455825864 0.281868349992839 0.578057806623792 GO:0000295 adenine nucleotide transmembrane transporter activity 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0005283 amino acid:sodium symporter activity 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0008171 O-methyltransferase activity 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0016849 phosphorus-oxygen lyase activity 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0017134 fibroblast growth factor binding 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0042171 lysophosphatidic acid acyltransferase activity 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0070577 lysine-acetylated histone binding 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0071617 lysophospholipid acyltransferase activity 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/275 23/18639 0.0434782608695652 2.94687747035573 0.289704286402906 0.578057806623792 GO:0035591 signaling adaptor activity 3/275 129/18639 0.0232558139534884 1.57623678646934 0.296855167054737 0.578057806623792 GO:0008234 cysteine-type peptidase activity 4/275 187/18639 0.0213903743315508 1.44980068060282 0.298261352486121 0.578057806623792 GO:0048029 monosaccharide binding 2/275 74/18639 0.027027027027027 1.83184275184275 0.298266880182202 0.578057806623792 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0005315 phosphate transmembrane transporter activity 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0005540 hyaluronic acid binding 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0030215 semaphorin receptor binding 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0050431 transforming growth factor beta binding 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0050699 WW domain binding 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0060229 lipase activator activity 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0070840 dynein complex binding 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0140033 acetylation-dependent protein binding 1/275 24/18639 0.0416666666666667 2.82409090909091 0.300196944398136 0.578057806623792 GO:0003725 double-stranded RNA binding 2/275 75/18639 0.0266666666666667 1.80741818181818 0.303721238188285 0.580682794857369 GO:0019003 GDP binding 2/275 75/18639 0.0266666666666667 1.80741818181818 0.303721238188285 0.580682794857369 GO:0005262 calcium channel activity 3/275 131/18639 0.0229007633587786 1.55217210270645 0.304914093555579 0.580682794857369 GO:0051536 iron-sulfur cluster binding 2/275 76/18639 0.0263157894736842 1.78363636363636 0.30916800865342 0.580682794857369 GO:0000030 mannosyltransferase activity 1/275 25/18639 0.04 2.71112727272727 0.310535157682612 0.580682794857369 GO:0005537 D-mannose binding 1/275 25/18639 0.04 2.71112727272727 0.310535157682612 0.580682794857369 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/275 25/18639 0.04 2.71112727272727 0.310535157682612 0.580682794857369 GO:0019211 phosphatase activator activity 1/275 25/18639 0.04 2.71112727272727 0.310535157682612 0.580682794857369 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/275 25/18639 0.04 2.71112727272727 0.310535157682612 0.580682794857369 GO:0019707 protein-cysteine S-acyltransferase activity 1/275 25/18639 0.04 2.71112727272727 0.310535157682612 0.580682794857369 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/275 26/18639 0.0384615384615385 2.60685314685315 0.320721191401172 0.58584075030074 GO:0004435 phosphatidylinositol phospholipase C activity 1/275 26/18639 0.0384615384615385 2.60685314685315 0.320721191401172 0.58584075030074 GO:0005112 Notch binding 1/275 26/18639 0.0384615384615385 2.60685314685315 0.320721191401172 0.58584075030074 GO:0005227 calcium-activated cation channel activity 1/275 26/18639 0.0384615384615385 2.60685314685315 0.320721191401172 0.58584075030074 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/275 26/18639 0.0384615384615385 2.60685314685315 0.320721191401172 0.58584075030074 GO:0015216 purine nucleotide transmembrane transporter activity 1/275 26/18639 0.0384615384615385 2.60685314685315 0.320721191401172 0.58584075030074 GO:0019865 immunoglobulin binding 1/275 26/18639 0.0384615384615385 2.60685314685315 0.320721191401172 0.58584075030074 GO:0050750 low-density lipoprotein particle receptor binding 1/275 26/18639 0.0384615384615385 2.60685314685315 0.320721191401172 0.58584075030074 GO:0051020 GTPase binding 6/275 315/18639 0.019047619047619 1.29101298701299 0.321442760984177 0.58584075030074 GO:0015370 solute:sodium symporter activity 2/275 79/18639 0.0253164556962025 1.71590333716916 0.325453335251378 0.589827193018603 GO:0016835 carbon-oxygen lyase activity 2/275 79/18639 0.0253164556962025 1.71590333716916 0.325453335251378 0.589827193018603 GO:0001671 ATPase activator activity 1/275 27/18639 0.037037037037037 2.51030303030303 0.330757277597093 0.591853070272299 GO:0015252 proton channel activity 1/275 27/18639 0.037037037037037 2.51030303030303 0.330757277597093 0.591853070272299 GO:0035255 ionotropic glutamate receptor binding 1/275 27/18639 0.037037037037037 2.51030303030303 0.330757277597093 0.591853070272299 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/275 27/18639 0.037037037037037 2.51030303030303 0.330757277597093 0.591853070272299 GO:0003779 actin binding 8/275 443/18639 0.018058690744921 1.22398522470757 0.331144994495475 0.591853070272299 GO:0030295 protein kinase activator activity 3/275 139/18639 0.0215827338129496 1.46283845650752 0.337206046739113 0.598906829766464 GO:0019789 SUMO transferase activity 1/275 28/18639 0.0357142857142857 2.42064935064935 0.340645615694063 0.598906829766464 GO:0045499 chemorepellent activity 1/275 28/18639 0.0357142857142857 2.42064935064935 0.340645615694063 0.598906829766464 GO:0046966 nuclear thyroid hormone receptor binding 1/275 28/18639 0.0357142857142857 2.42064935064935 0.340645615694063 0.598906829766464 GO:0051393 alpha-actinin binding 1/275 28/18639 0.0357142857142857 2.42064935064935 0.340645615694063 0.598906829766464 GO:0051537 2 iron, 2 sulfur cluster binding 1/275 28/18639 0.0357142857142857 2.42064935064935 0.340645615694063 0.598906829766464 GO:0003785 actin monomer binding 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0004629 phospholipase C activity 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0005416 amino acid:monoatomic cation symporter activity 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0016417 S-acyltransferase activity 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0035250 UDP-galactosyltransferase activity 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0097472 cyclin-dependent protein kinase activity 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0099604 ligand-gated calcium channel activity 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0106222 lncRNA binding 1/275 29/18639 0.0344827586206897 2.33717868338558 0.350388372971164 0.599738828868633 GO:0051117 ATPase binding 2/275 84/18639 0.0238095238095238 1.61376623376623 0.35235981847962 0.60152190648104 GO:0001965 G-protein alpha-subunit binding 1/275 30/18639 0.0333333333333333 2.25927272727273 0.359987685030967 0.601839876524639 GO:0001968 fibronectin binding 1/275 30/18639 0.0333333333333333 2.25927272727273 0.359987685030967 0.601839876524639 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/275 30/18639 0.0333333333333333 2.25927272727273 0.359987685030967 0.601839876524639 GO:0015215 nucleotide transmembrane transporter activity 1/275 30/18639 0.0333333333333333 2.25927272727273 0.359987685030967 0.601839876524639 GO:0022839 monoatomic ion-gated channel activity 1/275 30/18639 0.0333333333333333 2.25927272727273 0.359987685030967 0.601839876524639 GO:0031624 ubiquitin conjugating enzyme binding 1/275 30/18639 0.0333333333333333 2.25927272727273 0.359987685030967 0.601839876524639 GO:0033612 receptor serine/threonine kinase binding 1/275 30/18639 0.0333333333333333 2.25927272727273 0.359987685030967 0.601839876524639 GO:0051721 protein phosphatase 2A binding 1/275 30/18639 0.0333333333333333 2.25927272727273 0.359987685030967 0.601839876524639 GO:0008081 phosphoric diester hydrolase activity 2/275 87/18639 0.0229885057471264 1.55811912225705 0.368327390319965 0.611333349362546 GO:0008327 methyl-CpG binding 1/275 31/18639 0.032258064516129 2.18639296187683 0.369445656260828 0.611333349362546 GO:0016411 acylglycerol O-acyltransferase activity 1/275 31/18639 0.032258064516129 2.18639296187683 0.369445656260828 0.611333349362546 GO:0070325 lipoprotein particle receptor binding 1/275 31/18639 0.032258064516129 2.18639296187683 0.369445656260828 0.611333349362546 GO:0005096 GTPase activator activity 5/275 271/18639 0.018450184501845 1.25051995974505 0.370804947282083 0.61201734921303 GO:0019209 kinase activator activity 3/275 148/18639 0.0202702702702703 1.37388206388206 0.373428169971467 0.614186819814564 GO:0008378 galactosyltransferase activity 1/275 32/18639 0.03125 2.11806818181818 0.378764360287498 0.614186819814564 GO:0031369 translation initiation factor binding 1/275 32/18639 0.03125 2.11806818181818 0.378764360287498 0.614186819814564 GO:0042910 xenobiotic transmembrane transporter activity 1/275 32/18639 0.03125 2.11806818181818 0.378764360287498 0.614186819814564 GO:0051059 NF-kappaB binding 1/275 32/18639 0.03125 2.11806818181818 0.378764360287498 0.614186819814564 GO:0071813 lipoprotein particle binding 1/275 32/18639 0.03125 2.11806818181818 0.378764360287498 0.614186819814564 GO:0071814 protein-lipid complex binding 1/275 32/18639 0.03125 2.11806818181818 0.378764360287498 0.614186819814564 GO:0030296 protein tyrosine kinase activator activity 1/275 33/18639 0.0303030303030303 2.05388429752066 0.387945840425131 0.625937553005136 GO:0140416 transcription regulator inhibitor activity 1/275 33/18639 0.0303030303030303 2.05388429752066 0.387945840425131 0.625937553005136 GO:0005261 monoatomic cation channel activity 6/275 341/18639 0.0175953079178886 1.19257797920555 0.389558783975838 0.626976450826784 GO:0008376 acetylgalactosaminyltransferase activity 1/275 34/18639 0.0294117647058824 1.99347593582888 0.396992110116794 0.632847953507508 GO:0016831 carboxy-lyase activity 1/275 34/18639 0.0294117647058824 1.99347593582888 0.396992110116794 0.632847953507508 GO:0090482 vitamin transmembrane transporter activity 1/275 34/18639 0.0294117647058824 1.99347593582888 0.396992110116794 0.632847953507508 GO:0030246 carbohydrate binding 5/275 280/18639 0.0178571428571429 1.21032467532468 0.397119426775963 0.632847953507508 GO:0031267 small GTPase binding 5/275 283/18639 0.0176678445229682 1.19749437841311 0.405874091529258 0.643678025073802 GO:0005154 epidermal growth factor receptor binding 1/275 35/18639 0.0285714285714286 1.93651948051948 0.405905153369569 0.643678025073802 GO:0016409 palmitoyltransferase activity 1/275 36/18639 0.0277777777777778 1.88272727272727 0.414686925183339 0.647361377441159 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/275 36/18639 0.0277777777777778 1.88272727272727 0.414686925183339 0.647361377441159 GO:0055106 ubiquitin-protein transferase regulator activity 1/275 36/18639 0.0277777777777778 1.88272727272727 0.414686925183339 0.647361377441159 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 1/275 36/18639 0.0277777777777778 1.88272727272727 0.414686925183339 0.647361377441159 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 1/275 36/18639 0.0277777777777778 1.88272727272727 0.414686925183339 0.647361377441159 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 1/275 36/18639 0.0277777777777778 1.88272727272727 0.414686925183339 0.647361377441159 GO:0004896 cytokine receptor activity 2/275 96/18639 0.0208333333333333 1.41204545454545 0.415231795422072 0.647361377441159 GO:0016887 ATP hydrolysis activity 7/275 417/18639 0.0167865707434053 1.13776324395029 0.418590056741524 0.651028285364822 GO:0099106 ion channel regulator activity 3/275 160/18639 0.01875 1.27084090909091 0.421072884557189 0.653319319684656 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 8/275 484/18639 0.0165289256198347 1.12030052592036 0.422672960895278 0.653700622259564 GO:0030280 structural constituent of skin epidermis 1/275 37/18639 0.027027027027027 1.83184275184275 0.42333935197335 0.653700622259564 GO:0008083 growth factor activity 3/275 162/18639 0.0185185185185185 1.25515151515151 0.428904618997103 0.657449935989082 GO:0140297 DNA-binding transcription factor binding 8/275 488/18639 0.0163934426229508 1.11111773472429 0.431633294731882 0.657449935989082 GO:0000146 microfilament motor activity 1/275 38/18639 0.0263157894736842 1.78363636363636 0.431864331986646 0.657449935989082 GO:0005109 frizzled binding 1/275 38/18639 0.0263157894736842 1.78363636363636 0.431864331986646 0.657449935989082 GO:0042162 telomeric DNA binding 1/275 38/18639 0.0263157894736842 1.78363636363636 0.431864331986646 0.657449935989082 GO:0043531 ADP binding 1/275 38/18639 0.0263157894736842 1.78363636363636 0.431864331986646 0.657449935989082 GO:0001216 DNA-binding transcription activator activity 8/275 491/18639 0.0162932790224033 1.10432882799482 0.438345065918543 0.663987498848379 GO:0000217 DNA secondary structure binding 1/275 39/18639 0.0256410256410256 1.7379020979021 0.440263735712449 0.663987498848379 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1/275 39/18639 0.0256410256410256 1.7379020979021 0.440263735712449 0.663987498848379 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/275 39/18639 0.0256410256410256 1.7379020979021 0.440263735712449 0.663987498848379 GO:0042578 phosphoric ester hydrolase activity 6/275 363/18639 0.0165289256198347 1.12030052592036 0.44724113298835 0.665607788686757 GO:0015036 disulfide oxidoreductase activity 1/275 40/18639 0.025 1.69445454545455 0.448539406286594 0.665607788686757 GO:0015144 carbohydrate transmembrane transporter activity 1/275 40/18639 0.025 1.69445454545455 0.448539406286594 0.665607788686757 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/275 40/18639 0.025 1.69445454545455 0.448539406286594 0.665607788686757 GO:0030331 nuclear estrogen receptor binding 1/275 40/18639 0.025 1.69445454545455 0.448539406286594 0.665607788686757 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1/275 40/18639 0.025 1.69445454545455 0.448539406286594 0.665607788686757 GO:0050997 quaternary ammonium group binding 1/275 40/18639 0.025 1.69445454545455 0.448539406286594 0.665607788686757 GO:0005253 monoatomic anion channel activity 2/275 103/18639 0.0194174757281553 1.31608120035304 0.450486546647075 0.666967495836744 GO:0016247 channel regulator activity 3/275 168/18639 0.0178571428571429 1.21032467532468 0.452165353139565 0.667924619820317 GO:0017080 sodium channel regulator activity 1/275 41/18639 0.024390243902439 1.65312638580931 0.456693159890077 0.671546532838363 GO:0042287 MHC protein binding 1/275 41/18639 0.024390243902439 1.65312638580931 0.456693159890077 0.671546532838363 GO:0141108 transporter regulator activity 3/275 170/18639 0.0176470588235294 1.19608556149733 0.459833719910866 0.674631330572178 GO:0008307 structural constituent of muscle 1/275 42/18639 0.0238095238095238 1.61376623376623 0.464726786141836 0.675681417154535 GO:0016859 cis-trans isomerase activity 1/275 42/18639 0.0238095238095238 1.61376623376623 0.464726786141836 0.675681417154535 GO:0019894 kinesin binding 1/275 42/18639 0.0238095238095238 1.61376623376623 0.464726786141836 0.675681417154535 GO:0035198 miRNA binding 1/275 42/18639 0.0238095238095238 1.61376623376623 0.464726786141836 0.675681417154535 GO:0140030 modification-dependent protein binding 3/275 173/18639 0.0173410404624277 1.17534419337888 0.471249616103395 0.681067717973994 GO:0005245 voltage-gated calcium channel activity 1/275 43/18639 0.0232558139534884 1.57623678646934 0.472642048485817 0.681067717973994 GO:0008200 ion channel inhibitor activity 1/275 43/18639 0.0232558139534884 1.57623678646934 0.472642048485817 0.681067717973994 GO:0008375 acetylglucosaminyltransferase activity 1/275 43/18639 0.0232558139534884 1.57623678646934 0.472642048485817 0.681067717973994 GO:0001046 core promoter sequence-specific DNA binding 1/275 44/18639 0.0227272727272727 1.5404132231405 0.480440684572416 0.687710448934409 GO:0001223 transcription coactivator binding 1/275 44/18639 0.0227272727272727 1.5404132231405 0.480440684572416 0.687710448934409 GO:0016248 channel inhibitor activity 1/275 44/18639 0.0227272727272727 1.5404132231405 0.480440684572416 0.687710448934409 GO:0042605 peptide antigen binding 1/275 45/18639 0.0222222222222222 1.50618181818182 0.488124406634399 0.692580024325562 GO:0051539 4 iron, 4 sulfur cluster binding 1/275 45/18639 0.0222222222222222 1.50618181818182 0.488124406634399 0.692580024325562 GO:0140303 intramembrane lipid transporter activity 1/275 45/18639 0.0222222222222222 1.50618181818182 0.488124406634399 0.692580024325562 GO:0141110 transporter inhibitor activity 1/275 45/18639 0.0222222222222222 1.50618181818182 0.488124406634399 0.692580024325562 GO:0005216 monoatomic ion channel activity 7/275 448/18639 0.015625 1.05903409090909 0.492534342611297 0.69720565543849 GO:0005200 structural constituent of cytoskeleton 2/275 112/18639 0.0178571428571429 1.21032467532468 0.493992029538745 0.69720565543849 GO:0004180 carboxypeptidase activity 1/275 46/18639 0.0217391304347826 1.47343873517787 0.49569490185735 0.69720565543849 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/275 46/18639 0.0217391304347826 1.47343873517787 0.49569490185735 0.69720565543849 GO:0001784 phosphotyrosine residue binding 1/275 47/18639 0.0212765957446809 1.44208897485493 0.503153832744739 0.697875133509189 GO:0005504 fatty acid binding 1/275 47/18639 0.0212765957446809 1.44208897485493 0.503153832744739 0.697875133509189 GO:0001221 transcription coregulator binding 2/275 115/18639 0.0173913043478261 1.17875098814229 0.508004541054368 0.697875133509189 GO:0032266 phosphatidylinositol-3-phosphate binding 1/275 48/18639 0.0208333333333333 1.41204545454545 0.510502837477699 0.697875133509189 GO:0140693 molecular condensate scaffold activity 1/275 48/18639 0.0208333333333333 1.41204545454545 0.510502837477699 0.697875133509189 GO:1901981 phosphatidylinositol phosphate binding 3/275 185/18639 0.0162162162162162 1.09910565110565 0.515763720954918 0.697875133509189 GO:1990782 protein tyrosine kinase binding 2/275 117/18639 0.0170940170940171 1.1586013986014 0.517205062278649 0.697875133509189 GO:0001222 transcription corepressor binding 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0005004 GPI-linked ephrin receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0005008 hepatocyte growth factor receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0005009 insulin receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0005011 macrophage colony-stimulating factor receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0005018 platelet-derived growth factor alpha-receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0005020 stem cell factor receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0008288 boss receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0035254 glutamate receptor binding 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0036332 placental growth factor receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0038062 protein tyrosine kinase collagen receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0060175 brain-derived neurotrophic factor receptor activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0060590 ATPase regulator activity 1/275 49/18639 0.0204081632653061 1.38322820037106 0.517743530269568 0.697875133509189 GO:0005007 fibroblast growth factor receptor activity 1/275 50/18639 0.02 1.35556363636364 0.524877501715285 0.70019740950472 GO:0005017 platelet-derived growth factor receptor activity 1/275 50/18639 0.02 1.35556363636364 0.524877501715285 0.70019740950472 GO:0005019 platelet-derived growth factor beta-receptor activity 1/275 50/18639 0.02 1.35556363636364 0.524877501715285 0.70019740950472 GO:0015605 organophosphate ester transmembrane transporter activity 1/275 50/18639 0.02 1.35556363636364 0.524877501715285 0.70019740950472 GO:0032813 tumor necrosis factor receptor superfamily binding 1/275 50/18639 0.02 1.35556363636364 0.524877501715285 0.70019740950472 GO:0005010 insulin-like growth factor receptor activity 1/275 51/18639 0.0196078431372549 1.32898395721925 0.531906319135711 0.703769710594693 GO:0005030 neurotrophin receptor activity 1/275 51/18639 0.0196078431372549 1.32898395721925 0.531906319135711 0.703769710594693 GO:0005272 sodium channel activity 1/275 51/18639 0.0196078431372549 1.32898395721925 0.531906319135711 0.703769710594693 GO:0016830 carbon-carbon lyase activity 1/275 51/18639 0.0196078431372549 1.32898395721925 0.531906319135711 0.703769710594693 GO:0003697 single-stranded DNA binding 2/275 121/18639 0.0165289256198347 1.12030052592036 0.535261225872651 0.706763292121643 GO:0003924 GTPase activity 5/275 331/18639 0.0151057401812689 1.02383960450426 0.541433231462996 0.711771283283361 GO:0005003 ephrin receptor activity 1/275 53/18639 0.0188679245283019 1.27883361921098 0.54565464684474 0.711771283283361 GO:0005005 transmembrane-ephrin receptor activity 1/275 53/18639 0.0188679245283019 1.27883361921098 0.54565464684474 0.711771283283361 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/275 53/18639 0.0188679245283019 1.27883361921098 0.54565464684474 0.711771283283361 GO:0038064 collagen receptor activity 1/275 53/18639 0.0188679245283019 1.27883361921098 0.54565464684474 0.711771283283361 GO:0051018 protein kinase A binding 1/275 53/18639 0.0188679245283019 1.27883361921098 0.54565464684474 0.711771283283361 GO:0015485 cholesterol binding 1/275 54/18639 0.0185185185185185 1.25515151515151 0.552377178433985 0.71589699104324 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 1/275 54/18639 0.0185185185185185 1.25515151515151 0.552377178433985 0.71589699104324 GO:0140463 chromatin-protein adaptor activity 1/275 54/18639 0.0185185185185185 1.25515151515151 0.552377178433985 0.71589699104324 GO:0004175 endopeptidase activity 6/275 405/18639 0.0148148148148148 1.00412121212121 0.553243424299258 0.71589699104324 GO:0016758 hexosyltransferase activity 3/275 197/18639 0.0152284263959391 1.03215505306876 0.558207462392494 0.720464915770943 GO:0008374 O-acyltransferase activity 1/275 55/18639 0.0181818181818182 1.2323305785124 0.559000599253498 0.720464915770943 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 4/275 268/18639 0.0149253731343284 1.01161465400271 0.560263264698457 0.720656724174754 GO:0019783 ubiquitin-like protein peptidase activity 2/275 127/18639 0.015748031496063 1.06737294201861 0.56146770463671 0.720773025595141 GO:0170055 lipid transmembrane transporter activity 1/275 56/18639 0.0178571428571429 1.21032467532468 0.565526365246034 0.723376417315336 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 2/275 128/18639 0.015625 1.05903409090909 0.565731788503184 0.723376417315336 GO:0015932 nucleobase-containing compound transmembrane transporter activity 1/275 57/18639 0.0175438596491228 1.18909090909091 0.571955911043663 0.729328000834225 GO:0016798 hydrolase activity, acting on glycosyl bonds 2/275 130/18639 0.0153846153846154 1.04274125874126 0.574170485462161 0.729328000834225 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2/275 130/18639 0.0153846153846154 1.04274125874126 0.574170485462161 0.729328000834225 GO:0016791 phosphatase activity 4/275 273/18639 0.0146520146520147 0.993086913086913 0.574895332960518 0.729328000834225 GO:0061980 regulatory RNA binding 1/275 58/18639 0.0172413793103448 1.16858934169279 0.578290650278567 0.730838314547835 GO:0031072 heat shock protein binding 2/275 131/18639 0.0152671755725191 1.0347814018043 0.578345003166138 0.730838314547835 GO:0003714 transcription corepressor activity 3/275 204/18639 0.0147058823529412 0.996737967914439 0.5819147680567 0.731512936944662 GO:0005179 hormone activity 2/275 132/18639 0.0151515151515152 1.02694214876033 0.582489583170418 0.731512936944662 GO:0015459 potassium channel regulator activity 1/275 59/18639 0.0169491525423729 1.14878274268105 0.58453197588932 0.731512936944662 GO:0045309 protein phosphorylated amino acid binding 1/275 59/18639 0.0169491525423729 1.14878274268105 0.58453197588932 0.731512936944662 GO:0070063 RNA polymerase binding 1/275 59/18639 0.0169491525423729 1.14878274268105 0.58453197588932 0.731512936944662 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 5/275 349/18639 0.0143266475644699 0.971034123469654 0.5885671682077 0.734576822687001 GO:0001217 DNA-binding transcription repressor activity 4/275 278/18639 0.0143884892086331 0.975225637671681 0.589250959775199 0.734576822687001 GO:0005516 calmodulin binding 3/275 207/18639 0.0144927536231884 0.982292490118577 0.591826535108718 0.736368785029502 GO:0051015 actin filament binding 3/275 209/18639 0.0143540669856459 0.972892561983471 0.5983499473292 0.74215122438179 GO:0099094 ligand-gated monoatomic cation channel activity 2/275 136/18639 0.0147058823529412 0.996737967914439 0.598768066657333 0.74215122438179 GO:0016922 nuclear receptor binding 2/275 137/18639 0.0145985401459854 0.989462508294625 0.602762675450088 0.745673902516648 GO:0070851 growth factor receptor binding 2/275 139/18639 0.0143884892086331 0.975225637671681 0.610661898448972 0.754004290642147 GO:0016741 transferase activity, transferring one-carbon groups 3/275 215/18639 0.013953488372093 0.945742071881607 0.617509273779038 0.761006666923882 GO:0038024 cargo receptor activity 1/275 65/18639 0.0153846153846154 1.04274125874126 0.620093715759127 0.76273884809155 GO:0020037 heme binding 2/275 142/18639 0.0140845070422535 0.954622279129321 0.622286025143994 0.763983032766915 GO:0022843 voltage-gated monoatomic cation channel activity 2/275 143/18639 0.013986013986014 0.94794659885569 0.626100927491237 0.767210795618997 GO:0016500 protein-hormone receptor activity 1/275 67/18639 0.0149253731343284 1.01161465400271 0.6312602490884 0.772070663818893 GO:0008194 UDP-glycosyltransferase activity 2/275 145/18639 0.0137931034482759 0.934871473354232 0.633641262528096 0.772904337733706 GO:0005548 phospholipid transporter activity 1/275 68/18639 0.0147058823529412 0.996737967914439 0.636720265860998 0.772904337733706 GO:0032934 sterol binding 1/275 68/18639 0.0147058823529412 0.996737967914439 0.636720265860998 0.772904337733706 GO:0140223 general transcription initiation factor activity 1/275 68/18639 0.0147058823529412 0.996737967914439 0.636720265860998 0.772904337733706 GO:0001664 G protein-coupled receptor binding 4/275 297/18639 0.0134680134680135 0.912837465564738 0.641135333028053 0.77680629301339 GO:0097110 scaffold protein binding 1/275 70/18639 0.0142857142857143 0.96825974025974 0.647399809381978 0.782930236766617 GO:0046906 tetrapyrrole binding 2/275 152/18639 0.0131578947368421 0.891818181818182 0.659098939269131 0.794920924757303 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 3/275 229/18639 0.0131004366812227 0.887923779277491 0.659772081290064 0.794920924757303 GO:0005085 guanyl-nucleotide exchange factor activity 3/275 230/18639 0.0130434782608696 0.884063241106719 0.66265858155361 0.795648436456937 GO:0043539 protein serine/threonine kinase activator activity 1/275 73/18639 0.0136986301369863 0.928468244084682 0.66283540533275 0.795648436456937 GO:0005506 iron ion binding 2/275 154/18639 0.012987012987013 0.880236127508855 0.666108170116468 0.797206057348317 GO:0003684 damaged DNA binding 1/275 74/18639 0.0135135135135135 0.915921375921376 0.667829494718373 0.797206057348317 GO:0035064 methylated histone binding 1/275 74/18639 0.0135135135135135 0.915921375921376 0.667829494718373 0.797206057348317 GO:0140375 immune receptor activity 2/275 156/18639 0.0128205128205128 0.868951048951049 0.673001126266602 0.801900052844368 GO:0017022 myosin binding 1/275 76/18639 0.0131578947368421 0.891818181818182 0.677597634802174 0.804414072875241 GO:0140034 methylation-dependent protein binding 1/275 76/18639 0.0131578947368421 0.891818181818182 0.677597634802174 0.804414072875241 GO:0033293 monocarboxylic acid binding 1/275 79/18639 0.0126582278481013 0.85795166858458 0.691715770373315 0.81401649951616 GO:0046332 SMAD binding 1/275 79/18639 0.0126582278481013 0.85795166858458 0.691715770373315 0.81401649951616 GO:0022836 gated channel activity 4/275 318/18639 0.0125786163522013 0.852555746140652 0.693295485607462 0.81401649951616 GO:0048306 calcium-dependent protein binding 1/275 80/18639 0.0125 0.847227272727273 0.696283559335995 0.81401649951616 GO:0033192 calmodulin-dependent protein phosphatase activity 1/275 81/18639 0.0123456790123457 0.836767676767677 0.700783910711748 0.81401649951616 GO:0140791 histone H2AXS140 phosphatase activity 1/275 81/18639 0.0123456790123457 0.836767676767677 0.700783910711748 0.81401649951616 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 1/275 81/18639 0.0123456790123457 0.836767676767677 0.700783910711748 0.81401649951616 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 1/275 81/18639 0.0123456790123457 0.836767676767677 0.700783910711748 0.81401649951616 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 1/275 81/18639 0.0123456790123457 0.836767676767677 0.700783910711748 0.81401649951616 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 1/275 81/18639 0.0123456790123457 0.836767676767677 0.700783910711748 0.81401649951616 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 1/275 81/18639 0.0123456790123457 0.836767676767677 0.700783910711748 0.81401649951616 GO:1990439 MAP kinase serine/threonine phosphatase activity 1/275 81/18639 0.0123456790123457 0.836767676767677 0.700783910711748 0.81401649951616 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 1/275 82/18639 0.0121951219512195 0.826563192904656 0.70521781655043 0.81545702765807 GO:0033549 MAP kinase phosphatase activity 1/275 82/18639 0.0121951219512195 0.826563192904656 0.70521781655043 0.81545702765807 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 2/275 167/18639 0.0119760479041916 0.811714752313555 0.708871035838376 0.81545702765807 GO:0042393 histone binding 3/275 247/18639 0.0121457489878543 0.823216783216783 0.709025581224332 0.81545702765807 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 1/275 83/18639 0.0120481927710843 0.816604600219058 0.709586254360886 0.81545702765807 GO:0005254 chloride channel activity 1/275 83/18639 0.0120481927710843 0.816604600219058 0.709586254360886 0.81545702765807 GO:0017018 myosin phosphatase activity 1/275 84/18639 0.0119047619047619 0.806883116883117 0.713890187323311 0.818948495032238 GO:0005244 voltage-gated monoatomic ion channel activity 2/275 173/18639 0.0115606936416185 0.783562795585917 0.727018794101896 0.832533026166242 GO:0003823 antigen binding 2/275 174/18639 0.0114942528735632 0.779059561128527 0.729948886021506 0.833654755005289 GO:0004721 phosphoprotein phosphatase activity 2/275 175/18639 0.0114285714285714 0.774607792207792 0.732852343868822 0.833654755005289 GO:0022832 voltage-gated channel activity 2/275 175/18639 0.0114285714285714 0.774607792207792 0.732852343868822 0.833654755005289 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 1/275 89/18639 0.0112359550561798 0.761552604698672 0.734475013830591 0.833654755005289 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 1/275 89/18639 0.0112359550561798 0.761552604698672 0.734475013830591 0.833654755005289 GO:0004252 serine-type endopeptidase activity 2/275 176/18639 0.0113636363636364 0.770206611570248 0.735729312377156 0.833654755005289 GO:0140793 histone H2AXY142 phosphatase activity 1/275 90/18639 0.0111111111111111 0.753090909090909 0.738411368072995 0.83396373432375 GO:0043021 ribonucleoprotein complex binding 2/275 177/18639 0.0112994350282486 0.765855161787365 0.738579937816861 0.83396373432375 GO:0005319 lipid transporter activity 2/275 178/18639 0.0112359550561798 0.761552604698672 0.741404367918905 0.835237139992297 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 1/275 91/18639 0.010989010989011 0.744815184815185 0.742289575727312 0.835237139992297 GO:0005543 phospholipid binding 6/275 497/18639 0.0120724346076459 0.818247667825133 0.745392589774546 0.836626496933019 GO:0043178 alcohol binding 1/275 92/18639 0.0108695652173913 0.736719367588933 0.746110492628055 0.836626496933019 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 2/275 181/18639 0.0110497237569061 0.748930185836263 0.749721983866191 0.837943178673365 GO:0051219 phosphoprotein binding 1/275 93/18639 0.010752688172043 0.728797653958944 0.749874962058544 0.837943178673365 GO:0016410 N-acyltransferase activity 1/275 94/18639 0.0106382978723404 0.721044487427466 0.753583814934307 0.840635738383615 GO:0008237 metallopeptidase activity 2/275 184/18639 0.0108695652173913 0.736719367588933 0.757809285021363 0.843894332889538 GO:0015276 ligand-gated monoatomic ion channel activity 2/275 186/18639 0.010752688172043 0.728797653958944 0.763074928976198 0.848298073964948 GO:0004725 protein tyrosine phosphatase activity 1/275 98/18639 0.0102040816326531 0.691614100185529 0.767879256375554 0.849661775125509 GO:0005249 voltage-gated potassium channel activity 1/275 98/18639 0.0102040816326531 0.691614100185529 0.767879256375554 0.849661775125509 GO:0022834 ligand-gated channel activity 2/275 188/18639 0.0106382978723404 0.721044487427466 0.768241326813637 0.849661775125509 GO:0043130 ubiquitin binding 1/275 100/18639 0.01 0.677781818181818 0.774714002463821 0.855358292822683 GO:0008236 serine-type peptidase activity 2/275 194/18639 0.0103092783505155 0.698744142455483 0.783157807578749 0.863208009375555 GO:0004722 protein serine/threonine phosphatase activity 1/275 103/18639 0.00970873786407767 0.658040600176522 0.784591953009828 0.863318016322039 GO:0017171 serine hydrolase activity 2/275 198/18639 0.0101010101010101 0.684628099173554 0.79262945960829 0.86943317711655 GO:0035091 phosphatidylinositol binding 3/275 284/18639 0.0105633802816901 0.715966709346991 0.792837054866715 0.86943317711655 GO:0004843 cysteine-type deubiquitinase activity 1/275 108/18639 0.00925925925925926 0.627575757575757 0.800105395151391 0.874439511254983 GO:0005496 steroid binding 1/275 108/18639 0.00925925925925926 0.627575757575757 0.800105395151391 0.874439511254983 GO:0004620 phospholipase activity 1/275 109/18639 0.00917431192660551 0.621818181818182 0.803071830655863 0.876201474594171 GO:0008168 methyltransferase activity 2/275 204/18639 0.00980392156862745 0.664491978609626 0.806154059468942 0.878083630431659 GO:0035401 histone H3Y41 kinase activity 1/275 115/18639 0.00869565217391304 0.589375494071146 0.819971586450972 0.888645923674671 GO:0101005 deubiquitinase activity 1/275 115/18639 0.00869565217391304 0.589375494071146 0.819971586450972 0.888645923674671 GO:0140801 histone H2AXY142 kinase activity 1/275 115/18639 0.00869565217391304 0.589375494071146 0.819971586450972 0.888645923674671 GO:0032182 ubiquitin-like protein binding 1/275 120/18639 0.00833333333333333 0.564818181818182 0.832945178321311 0.90119653908677 GO:0042826 histone deacetylase binding 1/275 127/18639 0.0078740157480315 0.533686471009306 0.849557925571625 0.913143533637016 GO:0001653 peptide receptor activity 1/275 128/18639 0.0078125 0.529517045454545 0.851792777044605 0.913143533637016 GO:0016298 lipase activity 1/275 130/18639 0.00769230769230769 0.521370629370629 0.856163727005696 0.913143533637016 GO:0016779 nucleotidyltransferase activity 1/275 136/18639 0.00735294117647059 0.498368983957219 0.868520791081927 0.913143533637016 GO:0140789 histone phosphatase activity 1/275 136/18639 0.00735294117647059 0.498368983957219 0.868520791081927 0.913143533637016 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 2/275 243/18639 0.00823045267489712 0.557845117845118 0.876419979314484 0.913143533637016 GO:0004676 3-phosphoinositide-dependent protein kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0004711 ribosomal protein S6 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0035175 histone H3S10 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0035979 histone H2AXS139 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0044022 histone H3S28 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0044023 histone H4S1 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0044024 histone H2AS1 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0044025 histone H2BS14 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0072354 histone H3T3 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0072371 histone H2AS121 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0072518 Rho-dependent protein serine/threonine kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0140823 histone H2BS36 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0140855 histone H3S57 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0140995 histone H2A kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0140997 histone H4 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0140998 histone H2B kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:1990244 histone H2AT120 kinase activity 2/275 245/18639 0.00816326530612245 0.553291280148423 0.879300345285061 0.913143533637016 GO:0004677 DNA-dependent protein kinase activity 2/275 246/18639 0.00813008130081301 0.551042128603104 0.88071724290223 0.913143533637016 GO:0140857 histone H3T45 kinase activity 2/275 246/18639 0.00813008130081301 0.551042128603104 0.88071724290223 0.913143533637016 GO:0035402 histone H3T11 kinase activity 2/275 247/18639 0.00809716599190283 0.548811188811189 0.882118807487355 0.913143533637016 GO:0035403 histone H3T6 kinase activity 2/275 247/18639 0.00809716599190283 0.548811188811189 0.882118807487355 0.913143533637016 GO:0004679 AMP-activated protein kinase activity 2/275 248/18639 0.00806451612903226 0.546598240469208 0.883505180922368 0.913143533637016 GO:0061630 ubiquitin protein ligase activity 3/275 353/18639 0.0084985835694051 0.576018542364152 0.89582760256146 0.922714847806155 GO:0141003 histone H2AX kinase activity 3/275 354/18639 0.00847457627118644 0.574391371340524 0.896905506350955 0.922714847806155 GO:0003774 cytoskeletal motor activity 1/275 153/18639 0.0065359477124183 0.442994652406417 0.898080871068394 0.922714847806155 GO:0045182 translation regulator activity 3/275 356/18639 0.00842696629213483 0.571164453524004 0.899031385626141 0.922714847806155 GO:0140996 histone H3 kinase activity 3/275 357/18639 0.00840336134453781 0.569564553093965 0.900079510814223 0.922714847806155 GO:0003730 mRNA 3'-UTR binding 2/275 262/18639 0.00763358778625954 0.517390700902151 0.901396779521763 0.922714847806155 GO:0035173 histone kinase activity 3/275 360/18639 0.00833333333333333 0.564818181818182 0.903165521027522 0.922714847806155 GO:0106310 protein serine kinase activity 3/275 361/18639 0.00831024930747922 0.563253588516746 0.904174982239725 0.922714847806155 GO:0061659 ubiquitin-like protein ligase activity 3/275 372/18639 0.00806451612903226 0.546598240469208 0.914669151481238 0.931527367546997 GO:0005126 cytokine receptor binding 2/275 275/18639 0.00727272727272727 0.492932231404959 0.915689962534606 0.931527367546997 GO:0016755 aminoacyltransferase activity 4/275 496/18639 0.00806451612903226 0.546598240469208 0.937225295017632 0.951938407969244 GO:0140597 protein carrier chaperone 1/275 188/18639 0.00531914893617021 0.360522243713733 0.939712961310467 0.952969100263122 GO:0004674 protein serine/threonine kinase activity 3/275 433/18639 0.0069284064665127 0.469594793197565 0.956113531741309 0.968083654204424 GO:0004842 ubiquitin-protein transferase activity 3/275 449/18639 0.0066815144766147 0.452860903016805 0.963338801122781 0.973875319260061 GO:0005125 cytokine activity 1/275 234/18639 0.00427350427350427 0.28965034965035 0.969810119636997 0.978887905468233 GO:0046982 protein heterodimerization activity 2/275 369/18639 0.00542005420054201 0.367361419068736 0.973934733385561 0.980035429745663 GO:0019787 ubiquitin-like protein transferase activity 3/275 479/18639 0.00626304801670146 0.424498007211995 0.973976478093449 0.980035429745663 GO:0140104 molecular carrier activity 1/275 249/18639 0.00401606425702811 0.272201533406353 0.975914618738047 0.980460804850181 GO:0008017 microtubule binding 1/275 276/18639 0.0036231884057971 0.245573122529644 0.983969169790919 0.987020236984069 GO:0140097 catalytic activity, acting on DNA 1/275 336/18639 0.00297619047619048 0.201720779220779 0.993526590292009 0.995064557150046 GO:0015631 tubulin binding 1/275 385/18639 0.0025974025974026 0.176047225501771 0.996920041261324 0.996920041261324