category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/117	93/9376	6.03179854792758	ATP2B1/ATP1A4/CST3/KCNN4/VAMP2/ATP1B3/ADCY2	5.4817228151124
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/117	103/9376	5.44618703842005	COL14A1/ATP1A4/SLC3A2/KCNN4/MME/ATP1B3/COL21A1	5.10026495267825
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/117	59/9376	6.79125018108069	MGST3/GPX4/GSTO1/GSTA3/SMS	5.01599173117039
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/117	170/9376	3.77114127702363	PLCG2/GADD45G/MGST3/GADD45B/EGFR/GSTO1/GSTA3/BRD7	4.09868148367466
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	8/117	174/9376	3.68444837410355	LMAN1/LMAN2/TUSC3/ERP29/HSPA1A/RRBP1/HSP90B1/PDIA3	4.01777019723612
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/117	142/9376	3.95040327434694	MGST3/ITGAV/HSP90B1/GSTO1/GSTA3/PRKCZ/CDH5	3.98223738762043
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/117	227/9376	3.17722805828533	SLC26A2/MT-CYB/MT-ATP8/MGST3/EGFR/GSTO1/GSTA3/MT-ND6/NDUFB10	3.73272988945645
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/117	75/9376	5.34245014245014	CGA/ATP1A4/HSP90B1/ATP1B3/ADCY2	4.24421305947621
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/117	50/9376	6.41094017094017	SAT1/ARG2/CKMT1A/SMS	4.31227606171716
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/117	53/9376	6.0480567650379	ATP2B1/ATP1A4/AP2S1/ATP1B3	4.14267486745596
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/117	86/9376	4.6591134963228	ATP1A4/KCNN4/VAMP2/ATP1B3/ADCY2	3.83189655143529
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/117	61/9376	5.25486899257391	ATP2B1/ATP1A4/SLC34A2/ATP1B3	3.74762569200387
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/117	32/9376	7.51282051282051	ACSS1/ECHS1/LDHB	4.14833872698932
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/117	63/9376	5.08804775471442	GPX4/PTGES/PLA2G2A/HPGD	3.65963658601152
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/117	102/9376	3.92827216356628	ATP2B1/ATP1A4/ATP1B3/ADCY2/PLA2G2A	3.34252378392276
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/117	71/9376	4.51474659925364	PLCG2/ATP6V0B/EGFR/JAM3	3.34165439764409
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/117	73/9376	4.39105491160286	PLCG2/GADD45G/GADD45B/EGFR	3.26949945272961
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	7/117	204/9376	2.7497905144964	CD44/PLCG2/ITGAV/EGFR/PDCD4/EZR/ERBB4	2.84030936419575
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/117	205/9376	2.73637690223056	CD44/PLCG2/GADD45G/HLA-DRA/CCND2/GADD45B/PDIA3	2.82558977900242
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/117	115/9376	3.4842066146414	AKAP13/SLC34A2/EGFR/JUND/ADCY2	3.01303529404166
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/117	76/9376	4.21772379667116	ATP1A4/ATP1B3/EZR/ADCY2	3.16599781815824
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/117	76/9376	4.21772379667116	PLCG2/GADD45G/GADD45B/EGFR	3.16599781815824
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/117	42/9376	5.72405372405372	GPX4/SLC3A2/SAT1	3.44907074100436
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/117	79/9376	4.0575570702153	ATP6V0B/VAMP2/AP2S1/SLC1A2	3.06770242195033
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	5/117	122/9376	3.28429312035869	PLCG2/ATP1A4/ITGAV/ATP1B3/SLC16A2	2.85472005838651
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/117	88/9376	3.64257964257964	CD46/CD59/F13A1/F5	2.79965711444452
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/117	89/9376	3.60165178142706	CD44/ITGB4/ITGAV/ITGB8	2.77206222961177
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/117	51/9376	4.71392659627954	PLCG2/ATP6V0B/KDELR1	2.98944460817607
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/117	90/9376	3.56163342830009	ATP1A4/ATP1B3/ABCB1/ADCY2	2.74486142617137
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/117	52/9376	4.6232741617357	CGA/HSD17B1/ADCY2	2.94508791347148
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/117	138/9376	2.90350551220116	MT-CYB/MT-ATP8/ATP6V0B/MT-ND6/NDUFB10	2.53221880731124
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/117	139/9376	2.88261698333641	KRT23/HSPA1A/EGFR/HSP90B1/ADCY2	2.51362465513779
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/117	23/9376	6.96841322928279	ENPEP/MME	3.22139412418145
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/117	23/9376	6.96841322928279	ATP1A4/ATP1B3	3.22139412418145
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/117	98/9376	3.27088784231641	ATP2B1/ATP1A4/ATP1B3/ADCY2	2.54025939355389
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/117	100/9376	3.20547008547009	CD44/HLA-DRA/CD59/MME	2.49239762369426
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/117	59/9376	4.07475010864841	GADD45G/GADD45B/EGFR	2.66314191895569
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/117	105/9376	3.05282865282865	PLCG2/GADD45G/CFLAR/GADD45B	2.37782882180722
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/117	105/9376	3.05282865282865	ITGB4/ITGAV/ITGB8/ADCY2	2.37782882180722
NA	NA	hsa04518	Integrin signaling	5/117	154/9376	2.6018426018426	ITGB4/ITGAV/CCND2/EGFR/ITGB8	2.25301544155658
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	5/117	160/9376	2.5042735042735	HLA-DRA/ITGAV/JAM3/ITGB8/CDH5	2.15730768903909
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/117	217/9376	2.21576273189176	MGST3/EGFR/HSP90B1/GSTO1/GSTA3/ADCY2	2.03681315277541
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/117	70/9376	3.43443223443223	MGST3/GSTO1/GSTA3	2.29806184857351
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/117	116/9376	2.76333628057766	PLCG2/JAM3/EZR/CDH5	2.14810334552924
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/117	71/9376	3.38605994944023	SLC7A5/EGFR/LDHB	2.26855265320764
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/117	73/9376	3.29329118370214	MGST3/GSTO1/GSTA3	2.21108606776283
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/117	73/9376	3.29329118370214	GADD45G/GADD45B/EGFR	2.21108606776283
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/117	75/9376	3.20547008547009	MGST3/GSTO1/GSTA3	2.15557683611188
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/117	75/9376	3.20547008547009	GADD45G/CCND2/GADD45B	2.15557683611188
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	6/117	233/9376	2.063607351161	ITGB4/ATP1A4/FBN2/ITGAV/ITGB8/ATP1B3	1.84804038667468
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/117	77/9376	3.12221112221112	GADD45G/GADD45B/EGFR	2.10190146088211
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/117	79/9376	3.04316780266147	MGST3/GSTO1/GSTA3	2.04994728560674
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/117	37/9376	4.33171633171633	GADD45G/GADD45B	2.28252329763282
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/117	38/9376	4.21772379667116	ATP1A4/ATP1B3	2.23413880985673
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/117	82/9376	2.93183239524703	MGST3/GSTO1/GSTA3	1.97502029942167
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/117	82/9376	2.93183239524703	HSPA1A/HLA-DRA/PDIA3	1.97502029942167
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/117	133/9376	2.41012788381209	GADD45G/CCND2/GADD45B/EGFR	1.84108725412352
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	7/117	308/9376	1.82128982128982	MT-CYB/MT-ATP8/POLR2J3/AP2S1/SLC1A2/MT-ND6/NDUFB10	1.64745124155342
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/117	86/9376	2.79546809779368	PLCG2/EGFR/ERBB4	1.88024996192705
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/117	86/9376	2.79546809779368	ITGB4/ITGAV/ITGB8	1.88024996192705
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/117	87/9376	2.76333628057766	MT-CYB/ATP1A4/ATP1B3	1.85740587584539
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/117	87/9376	2.76333628057766	GADD45G/GADD45B/EGFR	1.85740587584539
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/117	254/9376	1.89299414496265	PLCG2/ATP2B1/MCOLN3/EGFR/ADCY2/ERBB4	1.62187344360989
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/117	44/9376	3.64257964257964	HLA-DRA/HSPD1	1.97498401646989
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/117	45/9376	3.56163342830009	ABCB8/ABCB1	1.93622432174311
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/117	323/9376	1.7367097986293	CD44/PLCG2/CCND2/EGFR/PDCD4/ABCB1/EZR	1.51460007587126
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/117	203/9376	1.97381162898404	ITGB4/ITGAV/CCND2/EGFR/ITGB8	1.57675350725495
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/117	93/9376	2.58505652054039	CGA/EGFR/ADCY2	1.72678623937907
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/117	93/9376	2.58505652054039	GADD45G/ITGAV/GADD45B	1.72678623937907
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/117	94/9376	2.55755591925805	HSP90B1/JUND/S100A9	1.70601686220357
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	5/117	205/9376	1.95455493016469	MT-CYB/MT-ATP8/MT-ND6/PRKCZ/NDUFB10	1.55333824741903
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/117	47/9376	3.41007455901073	ACSS1/LDHB	1.86190872790331
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/117	47/9376	3.41007455901073	PRKCZ/MAFA	1.86190872790331
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/117	150/9376	2.13698005698006	GADD45G/GADD45B/EGFR/ABCB1	1.57793198136439
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	6/117	268/9376	1.79410639112132	MT-CYB/MT-ATP8/UBB/PARK7/MT-ND6/NDUFB10	1.48262426763481
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/117	48/9376	3.33903133903134	ATP1A4/ATP1B3	1.82624448593273
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	7/117	333/9376	1.68455635122302	ITGB4/ATP6V0B/ITGAV/CCND2/EGFR/ITGB8/PRKCZ	1.42978778508711
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/117	99/9376	2.42838642838643	ITGB4/ITGAV/ITGB8	1.60603890378738
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/117	154/9376	2.08147408147408	ATP2B1/ATP1A4/ATP1B3/ADCY2	1.52110937891246
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/117	157/9376	2.04170069138222	DLG5/AMOT/CCND2/PRKCZ	1.47961047798222
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/117	158/9376	2.02877853510765	GADD45G/CDKN1C/CCND2/GADD45B	1.46598191594254
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/117	12/9376	6.67806267806268	CD46	2.21236423859371
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/117	104/9376	2.31163708086785	PISD/LPIN2/PLA2G2A	1.51195954541233
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/117	54/9376	2.96802785691675	SMS/LDHB	1.63030964963362
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/117	54/9376	2.96802785691675	CGA/HLA-DRA	1.63030964963362
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	5/117	226/9376	1.77293699417593	ATP2B1/CGA/ATP1A4/ATP1B3/ADCY2	1.32216085060821
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/117	166/9376	1.93100607558439	ATP2B1/ATP1A4/ATP1B3/ADCY2	1.36042082399245
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/117	227/9376	1.7651266990474	AKAP13/ITGAV/EGFR/ADCY2/PDIA3	1.31176487822991
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/117	56/9376	2.86202686202686	HSPA1A/HSPD1	1.57097229571721
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/117	110/9376	2.18554778554779	PLCG2/EGFR/LDHB	1.40593675697449
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	4/117	170/9376	1.88557063851181	AMOT/JAM3/PRKCZ/EZR	1.30981123504927
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/117	232/9376	1.72708517536104	ITGB4/ITGAV/EGFR/ITGB8/EZR	1.26054310326884
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	7/117	362/9376	1.54960570430184	ITGB4/ITGAV/CCND2/EGFR/HSP90B1/ITGB8/ERBB4	1.19879042917837
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/117	59/9376	2.71650007243228	CGA/ADCY2	1.48671701284834
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/117	235/9376	1.70503727950536	MT-CYB/MT-ATP8/MT-ND6/NDUFB10/ADCY2	1.23039819406106
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/117	300/9376	1.60273504273504	GADD45G/HSPA1A/GADD45B/EGFR/JUND/ERBB4	1.19271409791876
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	3/117	116/9376	2.07250221043324	SLC38A1/SLC1A2/ADCY2	1.3065265041586
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/117	62/9376	2.58505652054039	HSPA1A/ADCY2	1.40756677852742
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/117	178/9376	1.80082589071353	SERPINF1/CCND2/ZNRF3/NOTUM	1.21254518394852
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/117	63/9376	2.54402387735721	POLR2J3/DDB1	1.38221630721791
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/117	63/9376	2.54402387735721	GADD45G/GADD45B	1.38221630721791
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/117	17/9376	4.71392659627954	NRP2	1.72281871146788
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/117	65/9376	2.46574621959237	CGA/KCNN4	1.3329498949345
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/117	184/9376	1.7421033073207	PLCG2/PLXNB2/EPHB4/PRKCZ	1.14278570131733
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/117	18/9376	4.45204178537512	FUCA1	1.64784858406164
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/117	67/9376	2.39214185482842	ACSS1/LDHB	1.28548171637606
Organismal Systems	Immune system	hsa04611	Platelet activation	3/117	126/9376	1.90801790801791	PLCG2/PRKCZ/ADCY2	1.15346745918164
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/117	130/9376	1.84930966469428	EGFR/PRKCZ/ADCY2	1.09611803827965
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/117	71/9376	2.25737329962682	CGA/CCND2	1.19545090877119
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/117	20/9376	4.00683760683761	DHCR24	1.51313052187929
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/117	136/9376	1.76772247360483	HSPA1A/CD46/CCND2	1.01375789517809
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/117	201/9376	1.59476123655228	GADD45G/CCND2/GADD45B/HPGD	0.958151480488933
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/117	137/9376	1.75481938985589	GADD45G/CFLAR/GADD45B	1.00043153967491
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/117	77/9376	2.08147408147408	GADD45G/GADD45B	1.07112432310133
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/117	23/9376	3.4842066146414	ARG2	1.34082683021935
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/117	78/9376	2.05478851632698	BTG3/HSPD1	1.05151252557287
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	5/117	275/9376	1.45703185703186	MT-CYB/MT-ATP8/HSPA1A/MT-ND6/NDUFB10	0.864698668084842
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	3/117	142/9376	1.69302997472012	UBB/DDB1/UBE2A	0.935400899283154
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/117	80/9376	2.0034188034188	PLCG2/EGFR	1.01315454768828
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/117	83/9376	1.93100607558439	SLC27A2/CROT	0.957657291661306
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/117	26/9376	3.08218277449047	PLA2G2A	1.19507798150378
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/117	26/9376	3.08218277449047	MAFA	1.19507798150378
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/117	148/9376	1.62439362439362	GADD45G/GADD45B/EGFR	0.860660857106681
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/117	149/9376	1.61349165376011	PLCG2/EGFR/ADCY2	0.848531676673428
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/117	149/9376	1.61349165376011	MT-ND6/NDUFB10/ADCY2	0.848531676673428
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/117	27/9376	2.96802785691675	ECHS1	1.15113715209769
NA	NA	hsa04081	Hormone signaling	4/117	219/9376	1.46368497053429	CGA/ITGAV/ADCY2/SLC16A2	0.780485783180887
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/117	28/9376	2.86202686202686	ECHS1	1.10918026227368
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	3/117	155/9376	1.55103391232423	ATP6V0B/HLA-DRA/ITGAV	0.777591836615243
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/117	89/9376	1.80082589071353	EGFR/ADCY2	0.853280681138848
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/117	89/9376	1.80082589071353	SLC38A1/ADCY2	0.853280681138848
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	6/117	368/9376	1.30657748049052	MT-CYB/MT-ATP8/SLC1A2/MT-ND6/NDUFB10/ERBB4	0.67444493635842
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	3/117	157/9376	1.53127551853666	BSG/ARG2/ITGAV	0.754612942494301
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	3/117	157/9376	1.53127551853666	GADD45G/CCND2/GADD45B	0.754612942494301
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/117	30/9376	2.67122507122507	PLA2G2A	1.03057406317552
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/117	158/9376	1.52158390133074	SLC3A2/SLC7A5/LPIN2	0.74324311880944
NA	NA	hsa04517	IgSF CAM signaling	5/117	299/9376	1.34007946716977	PLCG2/JAM3/NRP2/EPB41L3/EZR	0.67180211222194
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/117	31/9376	2.58505652054039	ECHS1	0.993647797319001
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/117	31/9376	2.58505652054039	ACSS1	0.993647797319001
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/117	31/9376	2.58505652054039	SPCS2	0.993647797319001
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/117	93/9376	1.72337101369359	EGFR/CDH5	0.788052095445741
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/117	32/9376	2.5042735042735	ATG9B	0.95814647762483
Human Diseases	Immune disease	hsa05310	Asthma	1/117	32/9376	2.5042735042735	HLA-DRA	0.95814647762483
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/117	95/9376	1.68708951866847	ATP6V0B/HLA-DRA	0.756613815165492
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/117	33/9376	2.42838642838643	VAMP2	0.923966100627801
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/117	34/9376	2.35696329813977	POLR2J3	0.891013235944808
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/117	99/9376	1.61892428559095	EGFR/ADCY2	0.69590165616511
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/117	99/9376	1.61892428559095	PLCG2/ADCY2	0.69590165616511
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/117	99/9376	1.61892428559095	KRT23/HLA-DRA	0.69590165616511
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	3/117	169/9376	1.42254589591868	UBB/CFLAR/ATG9B	0.623095615978783
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/117	101/9376	1.58686637894559	PLCG2/PRKCZ	0.666560362806319
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/117	36/9376	2.22602089268756	GALNT11	0.828461270219553
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/117	105/9376	1.52641432641433	UBB/ATG9B	0.609755303169329
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	4/117	250/9376	1.28218803418803	MCOLN3/ATP6V0B/FUCA1/AP2S1	0.508352417563353
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	4/117	250/9376	1.28218803418803	HSPA1A/AP2S1/EGFR/PRKCZ	0.508352417563353
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/117	106/9376	1.51201419125947	EGFR/HSP90B1	0.595924980399134
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/117	107/9376	1.49788321750939	ADCY2/LDHB	0.582236546485515
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/117	39/9376	2.05478851632698	HLA-DRA	0.741977172429904
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/117	253/9376	1.26698422350596	CD44/PLCG2/UBB/EGFR	0.483919975149915
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/117	181/9376	1.32823346083015	ATP6V0B/HLA-DRA/HSPD1	0.501236627884066
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/117	109/9376	1.47039912177527	SLC27A2/PRKCZ	0.555273179255785
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/117	41/9376	1.95455493016469	EGFR	0.688544826201332
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/117	112/9376	1.43101343101343	HSPA1A/HLA-DRA	0.515818683620413
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/117	42/9376	1.90801790801791	ECHS1	0.662951393398874
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/117	43/9376	1.86364539852912	ECHS1	0.638051281632156
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/117	43/9376	1.86364539852912	PLA2G2A	0.638051281632156
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/117	44/9376	1.82128982128982	TUSC3	0.613807146547684
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/117	44/9376	1.82128982128982	VAMP2	0.613807146547684
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/117	116/9376	1.38166814028883	ACSS1/ECHS1	0.46494966278796
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/117	45/9376	1.78081671415005	HLA-DRA	0.590184487779782
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	3/117	193/9376	1.24564899694433	PLCG2/PRKCZ/ADCY2	0.387612598583814
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/117	122/9376	1.31371724814348	PLCG2/ADCY2	0.392057793702226
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/117	48/9376	1.66951566951567	ECHS1	0.522737459432633
NA	NA	hsa03272	Virion - Hepatitis viruses	1/117	48/9376	1.66951566951567	EGFR	0.522737459432633
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/117	49/9376	1.63544392115821	GALNT11	0.50130358235218
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/117	125/9376	1.28218803418803	ORMDL1/PRKCZ	0.357022664762564
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/117	50/9376	1.60273504273504	HLA-DRA	0.480352732470294
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	3/117	205/9376	1.17273295809881	CCND2/DDB1/DDX3X	0.281086715835643
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/117	51/9376	1.57130886542651	PLA2G2A	0.459862671777999
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/117	52/9376	1.54109138724523	LRPAP1	0.439812620719838
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	3/117	212/9376	1.13401064344461	EGFR/PRKCZ/ADCY2	0.221850907547226
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/117	134/9376	1.19607092741421	ADCY2/PLA2G2A	0.256968060814682
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/117	214/9376	1.12341241313204	PLCG2/DDB1/PDIA3	0.205289678373137
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/117	56/9376	1.43101343101343	TUSC3	0.363641455992247
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/117	56/9376	1.43101343101343	CCND2	0.363641455992247
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/117	216/9376	1.11301044634378	HSPA1A/HSP90B1/HSPD1	0.188883601935257
NA	NA	hsa04382	Cornified envelope formation	3/117	217/9376	1.10788136594588	KRT23/ITGB4/S100A9	0.180737720719599
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/117	57/9376	1.40590793222372	ECHS1	0.345522900974013
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/117	60/9376	1.33561253561254	PLCG2	0.293153839271922
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/117	142/9376	1.12868664981341	PLCG2/JUND	0.173691777198835
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	3/117	224/9376	1.07326007326007	HLA-DRA/CCND2/ADCY2	0.124746933611758
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	5/117	388/9376	1.03269010485505	MT-CYB/MT-ATP8/MME/MT-ND6/NDUFB10	0.0739259938028603
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/117	63/9376	1.27201193867861	ECHS1	0.243506167821097
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	6/117	480/9376	1.0017094017094	MT-CYB/MT-ATP8/UBB/PARK7/MT-ND6/NDUFB10	0.00432179231113129
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/117	65/9376	1.23287310979619	LPIN2	0.211774850984929
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/117	65/9376	1.23287310979619	ADCY2	0.211774850984929
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/117	66/9376	1.21419321419321	HSD17B1	0.196290536591572
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/117	66/9376	1.21419321419321	HLA-DRA	0.196290536591572
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/117	238/9376	1.01012712777419	PLCG2/EGFR/PLA2G2A	0.0177887617370848
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	3/117	238/9376	1.01012712777419	PLCG2/EGFR/F13A1	0.0177887617370848
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/117	68/9376	1.17848164906988	DHRS3	0.166041392149929
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/117	154/9376	1.04073704073704	EGFR/ADCY2	0.05729725362423
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/117	155/9376	1.03402260821616	EGFR/ADCY2	0.0480110240359857
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/117	69/9376	1.16140220488047	PLCG2	0.151260551205153
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/117	156/9376	1.02739425816349	CFLAR/EGFR	0.0387840278412516
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/117	70/9376	1.14481074481074	HLA-DRA	0.136698834005827
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	2/117	157/9376	1.02085034569111	MT-CYB/NDUFB10	0.0296154070063856
Genetic Information Processing	Transcription	hsa03040	Spliceosome	3/117	243/9376	0.989342618972249	HSPA1A/SF1/CTNNBL1	-0.0189209713521551
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/117	72/9376	1.11301044634378	DDX3X	0.10820479699647
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/117	163/9376	0.983273032352787	DDB1/DDX3X	-0.0242162566397703
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/117	75/9376	1.06849002849003	ARG2	0.066940612747545
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/117	76/9376	1.05443094916779	SLC27A2	0.0535559535855093
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/117	168/9376	0.954008954008954	CCND2/EGFR	-0.067614804954192
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/117	78/9376	1.02739425816349	PLCG2	0.0273091763342215
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/117	78/9376	1.02739425816349	HLA-DRA	0.0273091763342215
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/117	83/9376	0.965503037792194	AUTS2	-0.0354844809984004
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/117	180/9376	0.890408357075024	HLA-DRA/PDIA3	-0.166882476478763
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/117	90/9376	0.890408357075024	ADCY2	-0.117430491799576
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/117	90/9376	0.890408357075024	EGFR	-0.117430491799576
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/117	91/9376	0.880623649854419	PLCG2	-0.128630680033304
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/117	91/9376	0.880623649854419	ADCY2	-0.128630680033304
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	1/117	93/9376	0.861685506846797	HLA-DRA	-0.150682048487592
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/117	97/9376	0.826152083884043	ADCY2	-0.193464504791467
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	2/117	196/9376	0.817721960579103	PLCG2/UBB	-0.289892894622772
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/117	98/9376	0.817721960579103	PLCG2	-0.203899766976252
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/117	98/9376	0.817721960579103	PLCG2	-0.203899766976252
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/117	99/9376	0.809462142795476	EGFR	-0.214235591457163
NA	NA	hsa04082	Neuroactive ligand signaling	2/117	199/9376	0.805394493836705	SLC1A2/ADCY2	-0.311908940448501
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/117	101/9376	0.793433189472793	ADCY2	-0.23461771385872
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/117	103/9376	0.778026719774292	CFLAR	-0.254627736481483
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/117	103/9376	0.778026719774292	ARG2	-0.254627736481483
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/117	105/9376	0.763207163207163	PLCG2	-0.274281456149618
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/117	109/9376	0.735199560887634	HLA-DRA	-0.312578350782928
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/117	110/9376	0.728515928515929	ADCY2	-0.321951961519783
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/117	115/9376	0.696841322928279	ADCY2	-0.367693970512967
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/117	117/9376	0.684929505442326	BRD7	-0.385491805436535
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/117	119/9376	0.673418085182791	CFLAR	-0.403020378841942
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/117	120/9376	0.667806267806268	PLCG2	-0.411686770317561
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/117	128/9376	0.626068376068376	ADCY2	-0.478817259807198
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/117	133/9376	0.602531970953024	PLCG2	-0.518941104988104
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/117	138/9376	0.580701102440233	ADCY2	-0.557790112757764
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/117	138/9376	0.580701102440233	PRKCZ	-0.557790112757764
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/117	140/9376	0.572405372405372	ADCY2	-0.572994987376497
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/117	143/9376	0.560396868089176	HLA-DRA	-0.595461799901744
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/117	144/9376	0.55650522317189	ISL1	-0.602862658754271
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/117	144/9376	0.55650522317189	LPIN2	-0.602862658754271
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/117	154/9376	0.52036852036852	DHRS3	-0.674608809019886
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/117	168/9376	0.477004477004477	CFLAR	-0.768894020939262
NA	NA	hsa04519	Cadherin signaling	3/117	404/9376	0.595074892104595	KRT23/EGFR/CDH5	-0.935227532531488
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	1/117	173/9376	0.463218220443654	HLA-DRA	-0.801037104567015
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/117	187/9376	0.428538781479958	TXNIP	-0.887298949663251
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/117	195/9376	0.410957703265396	PLCG2	-0.934362327524862
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/117	200/9376	0.400683760683761	EZR	-0.963032332211215
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	1/117	248/9376	0.323132065067549	HSP90B1	-1.21433494413919
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/117	298/9376	0.268915275626685	IL1RL1	-1.44170790424275
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/117	370/9376	0.216585816585817	CGA	-1.72831479532977