category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	80/514	308/9376	4.7379857496589	MT-ATP8/MT-CYB/COX4I1/AP2S1/MT-ATP6/MT-CO2/SLC25A5/MT-ND1/CLTA/TGM2/MT-ND6/PSMB1/MT-ND5/NDUFA10/NDUFB9/PSMC1/PSMB2/NDUFV1/POLR2J3/NDUFS8/COX5A/SLC25A6/TUBB4B/UQCR10/SLC1A2/PSMB7/AP2A1/NDUFV2/MT-CO1/PSMB6/NDUFS6/SOD1/MT-ND3/PSMC5/MT-ND4L/NDUFB10/PSMD4/COX7B/NDUFS7/POLR2A/PSMD7/PSMD8/PSMC3/UQCRB/PSMA7/CLTC/PSMD11/NDUFS5/NDUFA6/COX7C/PSMD14/ADRM1/NDUFA12/NDUFB5/PSMD1/NDUFS2/COX6A1/PSMA3/ATG2A/PSMC6/UQCRFS1/NDUFC2/NDUFB8/COX7A2/PSMA4/PSMA1/COX6B1/UQCRC2/PSMB5/NDUFB11/RCOR1/NDUFB2/NDUFA11/NDUFA5/NDUFB7/WIPI2/NRBF2/PSMC4/COX5B/PSMB3	16.0641802578339
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	75/514	275/9376	4.97488503714185	MT-ATP8/MT-CYB/COX4I1/MT-ATP6/MT-CO2/SLC25A5/MT-ND1/MT-ND6/PSMB1/MT-ND5/NDUFA10/NDUFB9/PSMC1/PSMB2/HSPA1A/NDUFV1/NDUFS8/COX5A/SLC25A6/TUBB4B/UQCR10/PSMB7/NDUFV2/MT-CO1/PSMB6/NDUFS6/SOD1/MT-ND3/PSMC5/MT-ND4L/NDUFB10/PSMD4/COX7B/NDUFS7/PSMD7/PSMD8/C1QA/PSMC3/UQCRB/PSMA7/C1QB/PSMD11/NDUFS5/NDUFA6/COX7C/PSMD14/ADRM1/NDUFA12/NDUFB5/PSMD1/NDUFS2/HSPA8/COX6A1/PSMA3/C7/PSMC6/UQCRFS1/NDUFC2/NDUFB8/COX7A2/PSMA4/DDIT3/PSMA1/COX6B1/UQCRC2/PSMB5/C1QC/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/PSMC4/COX5B/PSMB3	16.111934473433
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	73/514	268/9376	4.9686973691852	MT-ATP8/MT-CYB/UBB/COX4I1/MT-ATP6/MT-CO2/SLC25A5/MT-ND1/MT-ND6/PSMB1/PARK7/MT-ND5/NDUFA10/NDUFB9/PSMC1/PSMB2/NDUFV1/NDUFS8/COX5A/SLC25A6/TUBB4B/UQCR10/PSMB7/NDUFV2/MT-CO1/PSMB6/NDUFS6/SOD1/MT-ND3/PSMC5/MT-ND4L/NDUFB10/PSMD4/COX7B/NDUFS7/PSMD7/PSMD8/PSMC3/UQCRB/PSMA7/PSMD11/NDUFS5/NDUFA6/COX7C/PSMD14/ADRM1/NDUFA12/NDUFB5/PSMD1/NDUFS2/COX6A1/PSMA3/SLC39A7/PSMC6/UQCRFS1/NDUFC2/NDUFB8/COX7A2/PSMA4/DDIT3/PSMA1/COX6B1/UQCRC2/PSMB5/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/PSMC4/COX5B/PSMB3/ADCY5	15.8746878436619
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	83/514	388/9376	3.90212202655542	MT-ATP8/MT-CYB/COX4I1/APP/MT-ATP6/MT-CO2/SLC25A5/MT-ND1/MT-ND6/PSMB1/MT-ND5/NDUFA10/NDUFB9/CTNNB1/PSMC1/PSMB2/MME/NDUFV1/NDUFS8/COX5A/SLC25A6/TUBB4B/UQCR10/HRAS/PSMB7/NDUFV2/MT-CO1/PSMB6/NDUFS6/LRP5/MT-ND3/PSMC5/MT-ND4L/NDUFB10/PSMD4/COX7B/NDUFS7/PSMD7/PSMD8/PSMC3/UQCRB/MAP2K2/PSMA7/PSMD11/NDUFS5/KRAS/NDUFA6/COX7C/LRP1/PSMD14/ADRM1/DVL3/NDUFA12/NDUFB5/PSMD1/NDUFS2/COX6A1/PSMA3/SLC39A7/ATG2A/PSMC6/UQCRFS1/NDUFC2/NDUFB8/COX7A2/PSMA4/DDIT3/PSMA1/FZD6/IRS1/COX6B1/UQCRC2/PSMB5/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/WIPI2/NRBF2/PSMC4/COX5B/PSMB3	14.0605181450791
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	77/514	368/9376	3.81678227034343	MT-ATP8/MT-CYB/COX4I1/MT-ATP6/MT-CO2/MT-ND1/MT-ND6/PSMB1/MT-ND5/NDUFA10/NDUFB9/PSMC1/PSMB2/NDUFV1/NDUFS8/COX5A/TUBB4B/UQCR10/SLC1A2/PSMB7/NDUFV2/MT-CO1/PSMB6/NDUFS6/SOD1/MT-ND3/PSMC5/MT-ND4L/NDUFB10/PSMD4/COX7B/NDUFS7/PSMD7/PSMD8/PSMC3/UQCRB/PSMA7/PSMD11/ERBB4/NDUFS5/NDUFA6/COX7C/PSMD14/CAT/ADRM1/NDUFA12/NDUFB5/PSMD1/VCP/SQSTM1/NDUFS2/COX6A1/PSMA3/ATG2A/PSMC6/UQCRFS1/NDUFC2/NDUFB8/COX7A2/PSMA4/DDIT3/PSMA1/SRSF3/COX6B1/UQCRC2/PSMB5/NDUFB11/TPR/NDUFB2/NDUFA11/NDUFA5/NDUFB7/WIPI2/NRBF2/PSMC4/COX5B/PSMB3	13.2759107442703
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	59/514	227/9376	4.74111657724678	SLC26A2/MT-ATP8/MT-CYB/MGST3/GSTA3/EGFR/COX4I1/MT-ATP6/MT-CO2/SLC25A5/MT-ND1/MT-ND6/MT-ND5/NDUFA10/NDUFB9/NDUFV1/NDUFS8/COX5A/SLC25A6/UQCR10/GSTA4/HRAS/NDUFV2/MT-CO1/NDUFS6/SOD1/MT-ND3/MT-ND4L/NDUFB10/COX7B/NDUFS7/UQCRB/MAP2K2/AKR1C3/NDUFS5/KRAS/NDUFA6/PTPN1/COX7C/CAT/GSTO1/NDUFA12/NDUFB5/PTPRJ/NDUFS2/COX6A1/UQCRFS1/NDUFC2/NDUFB8/COX7A2/COX6B1/UQCRC2/EPHX2/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/COX5B	13.7413272080737
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	85/514	480/9376	3.23022049286641	MT-ATP8/MT-CYB/UBB/COX4I1/APP/MT-ATP6/MT-CO2/SLC25A5/MT-ND1/MT-ND6/PSMB1/PARK7/MT-ND5/NDUFA10/NDUFB9/CTNNB1/PSMC1/PSMB2/NDUFV1/NDUFS8/COX5A/SLC25A6/TUBB4B/UQCR10/HRAS/PSMB7/NDUFV2/MT-CO1/PSMB6/NDUFS6/SOD1/LRP5/MT-ND3/PSMC5/MT-ND4L/NDUFB10/PSMD4/COX7B/NDUFS7/PSMD7/PSMD8/PSMC3/UQCRB/MAP2K2/PSMA7/PSMD11/NDUFS5/KRAS/NDUFA6/COX7C/PSMD14/CAT/ADRM1/DVL3/NDUFA12/NDUFB5/PSMD1/VCP/SQSTM1/NDUFS2/COX6A1/PSMA3/ATG2A/PSMC6/UQCRFS1/NDUFC2/NDUFB8/COX7A2/PSMA4/DDIT3/PSMA1/FZD6/COX6B1/UQCRC2/PSMB5/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/WIPI2/NRBF2/PSMC4/COX5B/PSMB3	12.0801508774276
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	44/514	138/9376	5.81604917385665	MT-ATP8/MT-CYB/COX4I1/MT-ATP6/MT-CO2/MT-ND1/MT-ND6/ATP6V0B/MT-ND5/NDUFA10/NDUFB9/NDUFV1/NDUFS8/COX5A/UQCR10/NDUFV2/MT-CO1/NDUFS6/MT-ND3/MT-ND4L/NDUFB10/COX7B/NDUFS7/UQCRB/ATP6V1C2/NDUFS5/NDUFA6/COX7C/NDUFA12/NDUFB5/NDUFS2/COX6A1/UQCRFS1/NDUFC2/NDUFB8/COX7A2/COX6B1/UQCRC2/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/COX5B	13.7259622993535
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	52/514	235/9376	4.03636062587963	MT-ATP8/MT-CYB/COX4I1/MT-ATP6/MT-CO2/MT-ND1/MT-ND6/ADCY2/MT-ND5/NDUFA10/NDUFB9/NDUFV1/NDUFS8/COX5A/COX19/UQCR10/HRAS/SLC25A29/NDUFV2/MT-CO1/NDUFS6/MT-ND3/MT-ND4L/COX20/NDUFB10/COX7B/NDUFS7/UQCRB/NDUFS5/ACSL3/KRAS/NDUFA6/COX7C/NDUFA12/NDUFB5/NDUFS2/COX6A1/UQCRFS1/SMARCA2/NDUFC2/NDUFB8/COX7A2/CPT2/COX6B1/UQCRC2/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/COX5B/ADCY5	11.3525063259485
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	48/514	205/9376	4.27112081237544	MT-ATP8/MT-CYB/COX4I1/MT-ATP6/MT-CO2/SLC25A5/MT-ND1/PRKCZ/MT-ND6/MT-ND5/NDUFA10/NDUFB9/NDUFV1/MPC2/NDUFS8/COX5A/SLC25A6/UQCR10/NDUFV2/MT-CO1/NDUFS6/MT-ND3/MT-ND4L/NDUFB10/COX7B/NDUFS7/UQCRB/NDUFS5/NDUFA6/COX7C/NDUFA12/NDUFB5/NDUFS2/COX6A1/UQCRFS1/NDUFC2/NDUFB8/COX7A2/CPT2/IRS1/COX6B1/UQCRC2/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/COX5B	11.4042437946529
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	22/514	46/9376	8.72407376078498	PSMB1/PSMC1/PSMB2/PSMB7/PSMB6/PSMC5/PSMD4/PSMD7/PSMD8/PSMC3/PSMA7/PSMD11/PSMD14/ADRM1/PSMD1/PSMA3/PSMC6/PSMA4/PSMA1/PSMB5/PSMC4/PSMB3	12.6469508636134
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	37/514	157/9376	4.29889216585293	MT-CYB/COX4I1/MT-CO2/NDUFA10/NDUFB9/NDUFV1/NDUFS8/COX5A/UQCR10/NDUFV2/MT-CO1/NDUFS6/NDUFB10/COX7B/NDUFS7/UQCRB/NDUFS5/NDUFA6/COX7C/NDUFA12/NDUFB5/NDUFS2/COX6A1/UQCRFS1/NDUFC2/NDUFB8/COX7A2/DDIT3/IRS1/COX6B1/UQCRC2/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/COX5B	10.0386973952238
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	28/514	144/9376	3.54690877648076	SLC25A5/PSMB1/PSMC1/PSMB2/SLC25A6/PSMB7/PSMB6/PSMC5/PSMD4/PSMD7/PSMD8/PSMC3/PSMA7/PSMD11/PSMD14/ADRM1/PSMD1/PSMA3/ATG2A/PSMC6/PSMA4/PSMA1/PUM1/PSMB5/WIPI2/NRBF2/PSMC4/PSMB3	7.41733788332387
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	28/514	149/9376	3.4278849920351	MT-ND1/MT-ND6/GABRE/ADCY2/MT-ND5/NDUFA10/NDUFB9/NDUFV1/NDUFS8/NDUFV2/NDUFS6/MT-ND3/MT-ND4L/NDUFB10/NDUFS7/NDUFS5/NDUFA6/NDUFA12/NDUFB5/NDUFS2/NDUFC2/NDUFB8/NDUFB11/NDUFB2/NDUFA11/NDUFA5/NDUFB7/ADCY5	7.19436237728381
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/514	87/9376	3.77405071783175	MT-CYB/ATP1A4/COX4I1/MT-CO2/ATP1B3/COX5A/UQCR10/MT-CO1/COX7B/UQCRB/COX7C/ASPH/COX6A1/UQCRFS1/COX7A2/COX6B1/UQCRC2/COX5B	6.26023832147747
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	10/514	37/9376	4.93006625302345	GADD45G/CTNNB1/HRAS/GADD45B/MAP2K2/KRAS/CCND1/CDH1/TPR/NCOA4	5.76835354924272
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	12/514	57/9376	3.84026213393406	ECHS1/HADHA/ACADVL/HSD17B4/HADHB/HACD3/ACSL3/ACAA1/HSD17B12/CPT2/ACADS/ACSF3	5.17979438716605
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	26/514	205/9376	2.31352377337003	PLCG2/CD44/GADD45G/CCND2/PSMC1/MDM2/HLA-DRA/PSMC5/PSMD4/HLA-DPB1/PSMD7/PSMD8/PSMC3/NEDD4/CALR/GADD45B/PSMD11/PSMD14/ADRM1/PDIA3/PSMD1/PSMC6/HLA-DPA1/CCND1/HLA-DRB1/PSMC4	4.57939226362787
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/514	43/9376	4.24215003167134	ECHS1/HADHA/ECI1/ACADVL/ALDH7A1/HADHB/ACSL3/ACAA1/CPT2/ACADS	5.13166181401347
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/514	48/9376	3.42023346303502	ECHS1/HADHA/ALDH7A1/HADHB/IVD/ACAA1/ACADS/OXCT1/ACSF3	4.04841416917108
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/514	42/9376	3.47452288308319	SLC40A1/SLC3A2/LPCAT3/GPX4/ACSL3/SAT2/STEAP3/NCOA4	3.87064682407433
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	12/514	83/9376	2.63728845342459	CROT/SLC27A2/HSD17B4/SOD1/PEX14/PMVK/ACSL3/CAT/IDH2/ACAA1/EPHX2/FAR2	3.60817507025143
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/514	157/9376	2.09135294555008	BSG/ITGAV/SIRPA/ARG2/ITGB5/PBX1/C1QA/CALR/MAP2K2/CD24/C1QB/LRP1/P2RY6/DNMT3A/UQCRFS1/RAB17/C1QC/CD47	3.32104276858979
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	19/514	170/9376	2.03872739757382	PLCG2/GADD45G/MGST3/GSTA3/EGFR/CTNNB1/GSTP1/BRD7/GSTA4/HRAS/LRP5/GADD45B/MAP2K2/KRAS/GSTO1/DVL3/CCND1/SMARCA2/FZD6	3.29148505127081
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	11/514	75/9376	2.67538261997406	GADD45G/CCND2/PMAIP1/SIAH1/MDM2/GADD45B/SESN1/PPM1D/CCND1/SIVA1/STEAP3	3.50817411839458
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/514	89/9376	2.45949372622743	CD44/ITGB4/ITGAV/LAMB4/FRAS1/LAMC2/ITGB8/ITGB5/LAMA5/COL6A2/CD47/DAG1	3.33166125167046
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/514	59/9376	2.78256281738442	GADD45G/EGFR/CTNNB1/HRAS/GADD45B/MAP2K2/KRAS/CCND1/CDH1	3.30776102941034
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	24/514	250/9376	1.75115953307393	MCOLN3/FUCA1/AP2S1/CLTA/ATP6V0B/TFEB/SLC38A9/CTSC/BORCS7/AP2A1/HEXA/ATP6V1C2/CLTC/VPS26A/SLC29A3/CLN3/ASAH1/AP1S3/CD164/AP5B1/LAMTOR1/TLR3/VAMP8/NPC1	2.8991005630276
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/514	50/9376	2.91859922178988	CKMT1A/CKMT1B/SMS/CKB/ARG2/ALDH7A1/GOT1/SAT2	3.27584153746981
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	9/514	62/9376	2.64792268105937	ADCY2/HSPA1A/HRAS/SOD1/KRAS/CAT/HSPA8/IRS1/ADCY5	3.13520457322243
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/514	41/9376	3.11435892569042	EGFR/MDM2/HRAS/MAP2K2/KRAS/CCND1/CDH1	3.26749405069227
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	17/514	160/9376	1.93813229571984	ITGAV/NRCAM/JAM3/HLA-DRA/ITGB8/CADM1/HLA-DPB1/CD86/CDH5/SELL/CDH3/HLA-DPA1/GLG1/CDH1/NRXN3/HLA-DRB1/CADM3	2.88239947614232
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	18/514	174/9376	1.88702535891587	TUSC3/ERP29/RRBP1/HSPA1A/UBXN4/LMAN2/UBXN1/BAG1/CALR/SIL1/DDOST/PDIA3/VCP/HSPA8/DNAJB12/ERLEC1/DDIT3/DNAJA2	2.84427032659321
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/514	32/9376	3.42023346303502	ACSS1/LDHB/ECHS1/HADHA/SUCLG1/ACADS	3.3026850494199
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/514	23/9376	3.96548807308408	GLUL/CPS1/ARG2/GOT1/ASS1	3.42914585195417
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	13/514	116/9376	2.04427747215886	ACSS1/TKT/ECHS1/GLDC/CPS1/GOT1/PC/SUCLG1/CAT/IDH2/FH/ACADS/PGP	2.72546579125335
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	14/514	133/9376	1.92013106696703	GADD45G/EGFR/CCND2/MDM2/FOXO4/HRAS/GABARAPL1/GADD45B/MAP2K2/KRAS/CAT/GABARAPL2/CCND1/IRS1	2.57377372595168
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/514	59/9376	2.47338917100838	MGST3/GSTA3/SMS/GSTP1/GSTA4/GPX4/GSTO1/IDH2	2.73405191305843
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/514	71/9376	2.31227051022086	CGA/CCND2/HRAS/MAP2K2/KRAS/CCND1/PRLR/SOCS1/SOCS2	2.67297981874722
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	13/514	122/9376	1.94373923582318	PLCG2/ATP1A4/ITGAV/ATP1B3/CTNNB1/MDM2/HRAS/MED16/MAP2K2/KRAS/BMP4/CCND1/SLC16A2	2.52678624318741
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/514	28/9376	3.25736520289049	ECHS1/HADHA/HADHB/HACD3/HSD17B12	2.88086438633631
Human Diseases	Cancer: specific types	hsa05218	Melanoma	9/514	73/9376	2.24892063322851	GADD45G/EGFR/MDM2/HRAS/GADD45B/MAP2K2/KRAS/CCND1/CDH1	2.57980027676099
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/514	73/9376	2.24892063322851	PLCG2/GADD45G/EGFR/HRAS/EML4/GADD45B/MAP2K2/KRAS/CCND1	2.57980027676099
NA	NA	hsa04518	Integrin signaling	15/514	154/9376	1.77674465612209	ITGB4/EGFR/ITGAV/CCND2/CTNNB1/LAMB4/FRAS1/LAMC2/ITGB8/ITGB5/LAMA5/PGF/CCND1/CDH1/COL6A2	2.34060107622723
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/514	76/9376	2.16014745033791	PLCG2/GADD45G/EGFR/MDM2/HRAS/GADD45B/MAP2K2/KRAS/CCND1	2.44556852690945
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	17/514	184/9376	1.68533243106073	PLCG2/EPHB4/SEMA6A/RASA1/PRKCZ/NRP1/SEMA3F/HRAS/BMP7/PLXNB2/KRAS/PLXNA2/RGMA/PLXNB1/SEMA3E/SEMA3G/EFNA5	2.26103097679366
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/514	53/9376	2.40922105572278	ATP2B1/ATP1A4/AP2S1/ATP1B3/CLTA/AP2A1/CLTC	2.47765333390099
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/514	31/9376	2.94213631228819	ACSS1/GLUL/GLDC/CAT/PGP	2.60838820259164
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	15/514	158/9376	1.73176377875191	SLC3A2/PRR5/SLC38A9/LPIN2/HRAS/LRP5/CLIP1/MAP2K2/ATP6V1C2/KRAS/SLC7A5/DVL3/FZD6/IRS1/LAMTOR1	2.23399617487817
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	11/514	105/9376	1.91098758569576	UBB/SIAH1/TFEB/ATG9B/HRAS/GABARAPL1/KRAS/VCP/SQSTM1/GABARAPL2/FIS1	2.26071149516889
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/514	32/9376	2.85019455252918	ATG9B/GABARAPL1/ATG2A/GABARAPL2/WIPI2	2.52480183440379
Organismal Systems	Digestive system	hsa04970	Salivary secretion	10/514	93/9376	1.96142420819213	ATP2B1/KCNN4/ATP1A4/ATP1B3/CST3/ADCY2/VAMP2/SLC4A2/ADRB1/ADCY5	2.24395259104122
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/514	44/9376	2.48744251857092	HSPD1/HLA-DRA/HLA-DPB1/CD86/HLA-DPA1/HLA-DRB1	2.3816639864724
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/514	82/9376	2.00208788080099	NFYB/HSPA1A/HLA-DRA/HLA-DPB1/CALR/PDIA3/HSPA8/HLA-DPA1/HLA-DRB1	2.19488983298566
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/514	70/9376	2.08471372984992	HLA-DRA/HLA-DPB1/CD55/CD86/HLA-DPA1/CCND1/HLA-DRB1/DAG1	2.1937339584391
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/514	59/9376	2.16421552463233	CGA/ADCY2/ADRB1/PDE3B/ABHD5/IRS1/ADCY5	2.16034279670653
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/514	47/9376	2.32866959185363	ACSS1/LDHB/ALDH7A1/PC/HAGH/FH	2.19912392326583
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	15/514	169/9376	1.61904542628877	UBB/CFLAR/ATG9B/HMGB1/HRAS/GABARAPL1/MAP2K2/KRAS/SQSTM1/ATG2A/GABARAPL2/IRS1/VAMP8/WIPI2/NRBF2	1.95572651957202
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	10/514	100/9376	1.82412451361868	CD44/CSF3R/MME/HLA-DRA/HLA-DPB1/CD55/CD24/HLA-DPA1/HLA-DRB1/CSF2RA	1.99532565846443
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	13/514	142/9376	1.66997314627062	UBB/DDB1/SIAH1/RHOBTB1/MDM2/NEDD4L/UBE2B/UBE2A/NEDD4/UBE2M/UBE2H/MGRN1/SOCS1	1.93734942276157
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	9/514	87/9376	1.88702535891587	GADD45G/EGFR/PMAIP1/CTNNB1/HRAS/GADD45B/MAP2K2/KRAS/CCND1	2.00176229955442
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	8/514	75/9376	1.94573281452659	TKT/GLUL/CPS1/ARG2/GOT1/PC/IDH2/ASS1	1.9803209984893
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/514	38/9376	2.40016383370879	ATP1A4/ATP1B3/NEDD4L/KRAS/IRS1	2.08278789044949
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	17/514	204/9376	1.5201037613489	PLCG2/CD44/EGFR/ITGAV/VAV3/PDCD4/CTNNB1/MDM2/DDX5/ITGB5/HRAS/MAP2K2/ERBB4/KRAS/CCND1/FZD6/ERBB3	1.80873265775208
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	20/514	250/9376	1.45929961089494	EGFR/AP2S1/PRKCZ/CLTA/SNX6/MDM2/HSPA1A/NEDD4L/SH3GLB2/HRAS/AP2A1/TSG101/DAB2/NEDD4/CLTC/VPS26A/CHMP4A/HSPA8/RAB11FIP4/ARPC5L	1.77266705927944
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	4/514	27/9376	2.70240668684248	ECHS1/HADHA/ACADS/OXCT1	2.1333589959413
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/514	27/9376	2.70240668684248	HSD17B4/HACD3/ACAA1/HSD17B12	2.1333589959413
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/514	39/9376	2.338621171306	HLA-DRA/HLA-DPB1/CD86/HLA-DPA1/HLA-DRB1	2.01737966272748
Genetic Information Processing	Translation	hsa03010	Ribosome	18/514	222/9376	1.47901987590704	RPS21/RPL18/MRPS15/MRPS21/RPS14/MRPL27/RPL3/FAU/RPL12/RPS5/MRPL4/RPS23/MRPS31/MRPS11/RPS4X/MRPL21/MRPL54/MRPL13	1.73950584323606
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/514	17/9376	3.21904325932708	GLUL/CPS1/CA8	2.20534647911903
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/514	17/9376	3.21904325932708	NRP2/MYH10/DAG1	2.20534647911903
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	15/514	178/9376	1.53718357889214	SERPINF1/CCND2/LGR5/SIAH1/CTNNB1/LGR4/ZNRF3/LRP5/TBL1X/RNF43/CBY1/DVL3/CCND1/FZD6/PRICKLE2	1.74255843911696
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/514	106/9376	1.72087218265913	EGFR/SPINT1/CTNNB1/MDM2/GSTP1/HRAS/SLC19A1/MAP2K2/KRAS/CCND1	1.79751555590578
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	18/514	224/9376	1.46581434130072	NFYB/SLC25A5/ADCY2/CCND2/NRP1/MSX2/HLA-DRA/SLC25A6/HRAS/FDPS/HLA-DPB1/CALR/MAP2K2/KRAS/HLA-DPA1/CCND1/HLA-DRB1/ADCY5	1.69933962194997
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	8/514	79/9376	1.84721469733537	AP2S1/CLTA/ATP6V0B/VAMP2/SLC1A2/AP2A1/ATP6V1C2/CLTC	1.82111317468136
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/514	150/9376	1.58090791180285	GADD45G/EGFR/ABCB1/CTNNB1/HRAS/LRP5/GADD45B/MAP2K2/KRAS/DVL3/CCND1/CDH1/FZD6	1.72721945333278
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/514	93/9376	1.76528178737291	EGFR/CTNNB1/SORBS1/WASF2/PTPN1/CDH5/PTPRJ/BAIAP2/CDH1	1.7861585292108
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	11/514	122/9376	1.64470243031192	PLCG2/ADCY2/HRAS/CSH2/MAP2K2/KRAS/GHR/IRS1/SOCS1/SOCS2/ADCY5	1.72613913889119
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/514	54/9376	2.02680501513186	LDHB/SMS/DNMT1/ADI1/GOT1/DNMT3A	1.82234935185135
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/514	54/9376	2.02680501513186	CGA/HLA-DRA/HLA-DPB1/CD86/HLA-DPA1/HLA-DRB1	1.82234935185135
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	5/514	42/9376	2.171576801927	ECHS1/HADHA/ALDH7A1/CAT/KMO	1.83257954838053
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/514	30/9376	2.43216601815824	PC/SUCLG1/IDH2/FH	1.89209278051531
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	13/514	155/9376	1.52991088238986	ITGAV/COLEC12/OLR1/ATP6V0B/HLA-DRA/TUBB4B/ITGB5/HLA-DPB1/CALR/ATP6V1C2/VAMP3/HLA-DPA1/HLA-DRB1	1.60206820468372
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/514	232/9376	1.4152690191869	ITGB4/EGFR/ITGAV/VAV3/IQGAP2/DIAPH2/GNA12/ITGB8/ITGB5/HRAS/WASF2/MAP2K2/KRAS/MYH10/C7/BAIAP2/TMSB4X/ARPC5L	1.54243453584221
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/514	112/9376	1.62868260144525	HSPA1A/LAMB4/HLA-DRA/LAMC2/LAMA5/HLA-DPB1/HSPA8/HLA-DPA1/HLA-DRB1/SOCS1	1.61191636530591
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/514	31/9376	2.35370904983055	ECHS1/HADHA/ALDH7A1/ACADS	1.81810035319271
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	12/514	142/9376	1.54151367348057	MGST3/GSTA3/ITGAV/PRKCZ/CTNNB1/GSTP1/GSTA4/BMP4/GSTO1/CDH5/SQSTM1/ASS1	1.56588545164066
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/514	157/9376	1.51042157178617	DLG5/AMOT/PRKCZ/CCND2/CTNNB1/FRMD6/BMP7/BMP4/DVL3/TEAD3/CCND1/CDH1/FZD6	1.55323891947557
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/514	203/9376	1.43773360679305	ITGB4/EGFR/ITGAV/CCND2/VAV3/CTNNB1/LAMB4/LAMC2/ITGB8/ITGB5/HRAS/LAMA5/RAPGEF1/PGF/CCND1/COL6A2	1.51846063525662
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/514	71/9376	1.79843261906067	EGFR/LDHB/HRAS/MAP2K2/KRAS/SLC7A5/IDH2	1.62633714676668
Human Diseases	Immune disease	hsa05310	Asthma	4/514	32/9376	2.28015564202335	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DRB1	1.74691861938769
NA	NA	hsa04517	IgSF CAM signaling	22/514	299/9376	1.34216519396692	PLCG2/EPB41L3/APP/RASA1/NRP2/NRP1/VAV3/CTNNB1/NRCAM/JAM3/TUBB4B/SORBS1/CADM1/MAP2K2/PPFIA1/CD86/PLXNA2/MYH10/BAIAP2/CDH1/ARPC5L/CADM3	1.44811009489108
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/514	45/9376	2.02680501513186	HLA-DRA/HLA-DPB1/CD86/HLA-DPA1/HLA-DRB1	1.66276727371813
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	18/514	238/9376	1.37958996828303	PLCG2/EGFR/NRP1/RPS21/RPL18/RPS14/RPL3/C1QA/FAU/C1QB/RPL12/RPS5/C7/F13A1/RPS23/RPS4X/C1QC/TLR3	1.42849575119576
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/514	88/9376	1.65829501238062	F5/CD46/C1QA/CD55/C1QB/C7/F13A1/C1QC	1.49417725875762
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/514	103/9376	1.59389520607457	COL14A1/KCNN4/ATP1A4/ATP1B3/SLC3A2/COL21A1/MME/KCNK5/COL6A2	1.4595521835113
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/514	47/9376	1.94055799321136	PRKCZ/MAFA/IRS1/SOCS1/SOCS2	1.55674789034975
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	8/514	89/9376	1.63966248415162	EGFR/ADCY2/ADRB1/TUBB4B/HRAS/MAP2K2/KRAS/ADCY5	1.46019038951534
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	7/514	75/9376	1.70251621271077	MGST3/GSTA3/PMAIP1/MDM2/GSTP1/GSTA4/GSTO1	1.47103662518754
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/514	76/9376	1.68011468359615	OLR1/DBI/SLC27A2/SORBS1/ACSL3/ACAA1/CPT2	1.43366868100023
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/514	77/9376	1.65829501238062	GADD45G/MDM2/HRAS/GADD45B/MAP2K2/KRAS/CCND1	1.39684792894185
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/514	23/9376	2.37929284385045	FDPS/PMVK/HMGCR	1.59494700958311
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/514	63/9376	1.7372614415416	GADD45G/CTNNB1/GADD45B/BMP4/DVL3/FZD6	1.41399645020838
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/514	138/9376	1.45401229346416	PRKCZ/SORBS1/HRAS/MAP2K2/KRAS/PTPN1/RAPGEF1/PDE3B/IRS1/SOCS1/SOCS2	1.2939559789714
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	8/514	93/9376	1.5691393665537	EGFR/CGA/ADCY2/HRAS/MAP3K4/MAP2K2/KRAS/ADCY5	1.32836446738038
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/514	50/9376	1.82412451361868	HLA-DRA/HLA-DPB1/CD86/HLA-DPA1/HLA-DRB1	1.40712103033201
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/514	12/9376	3.04020752269779	CD46/NPC1	1.70308212178126
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/514	37/9376	1.97202650120938	GLUL/CPS1/GOT1/ASS1	1.42669160192798
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	23/514	333/9376	1.2599058202171	ITGB4/EGFR/ITGAV/PRKCZ/ATP6V0B/CCND2/CTNNB1/PSMC1/MDM2/LAMB4/LAMC2/ITGB8/ITGB5/HRAS/LAMA5/MAP2K2/ATP6V1C2/KRAS/DVL3/CCND1/FZD6/COL6A2/TLR3	1.16300928290382
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/514	52/9376	1.7539658784795	HSD17B1/CGA/ADCY2/AKR1C3/ADCY5	1.31296623027813
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/514	99/9376	1.47404001100499	EGFR/ADCY2/MDM2/HRAS/MAP2K2/KRAS/CCND1/ADCY5	1.14190544383372
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/514	99/9376	1.47404001100499	KRT23/HLA-DRA/HLA-DPB1/C1QA/C1QB/HLA-DPA1/HLA-DRB1/C1QC	1.14190544383372
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/514	115/9376	1.42757570631027	EGFR/ADCY2/AKAP13/GNA12/SLC34A2/LRP5/GCM1/MMP15/ADCY5	1.11105184458741
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	6/514	70/9376	1.56353529738744	EGLN2/HRAS/MAP2K2/KRAS/RAPGEF1/FH	1.13969841501771
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	11/514	148/9376	1.35576821958145	GADD45G/EGFR/CTNNB1/HRAS/LRP5/GADD45B/MAP2K2/KRAS/DVL3/CCND1/FZD6	1.05061970020167
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/514	101/9376	1.44485109989598	ADCY2/CTNNB1/HRAS/MAP2K2/KRAS/DVL3/FZD6/ADCY5	1.08247960185539
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	7/514	86/9376	1.48475251108497	PLCG2/EGFR/HRAS/MAP2K2/ERBB4/KRAS/ERBB3	1.08758387754361
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/514	86/9376	1.48475251108497	KCNN4/ATP1A4/ATP1B3/ADCY2/VAMP2/PCLO/ADCY5	1.08758387754361
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	24/514	362/9376	1.20936431842122	ITGB4/EGFR/CSF3R/ITGAV/CCND2/MDM2/LAMB4/LAMC2/ITGB8/ITGB5/HRAS/LAMA5/CSH2/MAP2K2/ERBB4/KRAS/GHR/PGF/CCND1/PRLR/EFNA5/IRS1/COL6A2/ERBB3	0.978361830390225
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	3/514	28/9376	1.9544191217343	GGH/AKR1C3/MOCS2	1.21803598900257
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/514	166/9376	1.3186442267123	ATP2B1/ATP1A4/ATP1B3/SLC25A5/ADCY2/GNA12/ADRB1/SLC25A6/MAP2K2/PDE3B/IRS1/ADCY5	0.997542959952036
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	8/514	104/9376	1.4031727027836	PISD/PLPP3/LPCAT3/PLA2G2A/LPIN2/PTDSS1/PHOSPHO1/CHPT1	0.995686005504746
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/514	89/9376	1.43470467363267	SLC38A1/GABRE/ADCY2/GLUL/GABARAPL1/GABARAPL2/ADCY5	0.992322673976556
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/514	105/9376	1.38980915323328	ITGB4/ITGAV/ADCY2/ITGB8/ADRB1/ITGB5/DAG1/ADCY5	0.96735240685358
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	10/514	137/9376	1.33147774716692	GADD45G/CFLAR/PMAIP1/CTSC/HRAS/GADD45B/MAP2K2/KRAS/DDIT3/DFFA	0.941246779897866
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/514	44/9376	1.65829501238062	TUSC3/HEXA/ALG11/DDOST	1.0540491507313
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/514	90/9376	1.4187635105923	ADCY2/HRAS/KRAS/CAT/SESN1/IRS1/ADCY5	0.961340130104642
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/514	90/9376	1.4187635105923	ATP1A4/ATP1B3/ABCB1/ADCY2/SLC4A2/HMGCR/ADCY5	0.961340130104642
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/514	75/9376	1.45929961089494	ATP1A4/CGA/ATP1B3/ADCY2/LRP2/ADCY5	0.961752251885773
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/514	139/9376	1.31231979397027	KRT23/EGFR/ADCY2/HSPA1A/HRAS/MAP2K2/KRAS/HSPA8/FKBP5/ADCY5	0.893393447084765
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/514	76/9376	1.44009830022527	ATP1A4/ATP1B3/ADCY2/SLC4A2/GAST/ADCY5	0.927718758045615
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/514	61/9376	1.49518402755629	ATP2B1/ATP1A4/SLC40A1/ATP1B3/SLC34A2	0.934418526608436
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/514	157/9376	1.2780490222806	GADD45G/SLC25A5/CCND2/MDM2/SLC25A6/HRAS/GADD45B/MAP2K2/KRAS/SQSTM1/CCND1	0.846117379829881
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	7/514	93/9376	1.37299694573449	GADD45G/ITGAV/LAMB4/LAMC2/LAMA5/GADD45B/CCND1	0.870570405549957
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/514	78/9376	1.4031727027836	BTG3/HSPD1/BTG1/DHX36/DCP2/CNOT6L	0.861082920957258
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	6/514	78/9376	1.4031727027836	CLTA/CTNNB1/WASF2/CLTC/CDH1/ARPC5L	0.861082920957258
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	10/514	143/9376	1.27561154798509	HLA-DRA/HLA-DPB1/C1QA/C1QB/CD86/C7/HLA-DPA1/SNRPD3/HLA-DRB1/C1QC	0.799825665683396
Genetic Information Processing	Transcription	hsa03040	Spliceosome	16/514	243/9376	1.20106963859666	SF1/HSPA1A/DDX5/RBM8A/SYF2/HNRNPM/CTNNBL1/SRSF6/SF3B5/HSPA8/SNRPD3/CWC15/DDX39B/SRSF3/SNRPB2/BUD31	0.764793573863636
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/514	18/9376	2.02680501513186	ACSL3/ACSF3	1.05010817192015
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/514	18/9376	2.02680501513186	FUCA1/HEXA	1.05010817192015
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/514	63/9376	1.44771786795133	PLA2G2A/AKR1C3/GPX4/EPHX2/PTGES3	0.858679757691257
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/514	95/9376	1.34409174687692	ATP6V0B/HLA-DRA/HLA-DPB1/ATP6V1C2/CD86/HLA-DPA1/HLA-DRB1	0.811783084063334
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/514	144/9376	1.26675313445741	DUSP9/CTNNB1/ISL1/TBX3/HRAS/MAP2K2/KRAS/BMP4/DVL3/FZD6	0.776862582585439
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/514	33/9376	1.65829501238062	VAMP2/VAMP3/VAMP8	0.912295820018202
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/514	80/9376	1.36809338521401	PLCG2/EGFR/HRAS/MAP2K2/KRAS/ERBB3	0.796262519789303
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/514	65/9376	1.4031727027836	KCNN4/CGA/HRAS/MAP2K2/KRAS	0.785508628459168
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/514	66/9376	1.38191251031718	HSD17B1/COMT/STS/AKR1C3/HSD17B12	0.749829179510726
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	15/514	233/9376	1.17432908602061	FBN2/ITGB4/ATP1A4/ITGAV/ATP1B3/SYNE2/DIAPH2/ITGB8/ITGB5/CSRP2/PDLIM1/MYH10/PDLIM2/COL6A2/DAG1	0.648940350031808
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/514	99/9376	1.28978500962937	EGFR/PLPP3/HRAS/WASF2/MAP2K2/KRAS/CHPT1	0.698057278615873
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/514	20/9376	1.82412451361868	DHCR24/FDFT1	0.888513536268801
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/514	217/9376	1.17685452491528	MGST3/GSTA3/EGFR/ADCY2/ADRB1/GSTA4/HRAS/MAP2K2/KRAS/GSTO1/CCND1/EPHX2/PTGES3/ADCY5	0.634780150866
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/514	201/9376	1.17978202373347	GADD45G/MLLT1/SPINT1/CCND2/MDM2/DDX5/NUPR1/PBX1/GADD45B/CD86/DDIT3/PROM1/LMO2	0.620501137374137
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/514	168/9376	1.19436724105985	EGFR/CSF3R/CCND2/HRAS/CSH2/GHR/CCND1/PRLR/SOCS1/SOCS2/CSF2RA	0.612204306852202
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/514	52/9376	1.4031727027836	LRPAP1/LRP2/LRP1/NPC1	0.702090318453608
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/514	102/9376	1.25185015640497	ATP2B1/ATP1A4/ATP1B3/ADCY2/SLC4A2/PLA2G2A/ADCY5	0.615899837991462
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/514	69/9376	1.32182935769469	PLCG2/VAV3/HRAS/MAP2K2/KRAS	0.646169822588841
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	6/514	86/9376	1.2726450095014	ITGB4/ITGAV/CTNNB1/ITGB8/ITGB5/DAG1	0.61170248703358
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/514	103/9376	1.23969627139133	RBM8A/PABPN1/GSPT2/SAP18/DDX39B/PAPOLA/UPF3B	0.58907566976523
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/514	70/9376	1.3029460811562	MGST3/GSTA3/GSTP1/GSTA4/GSTO1	0.612680643307015
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/514	155/9376	1.17685452491528	EGFR/ADCY2/CTNNB1/PBX1/MAP2K2/DVL3/CCND1/FH/FZD6/ADCY5	0.534680491827978
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/514	71/9376	1.28459472790048	PLCG2/EGFR/ATP6V0B/JAM3/ATP6V1C2	0.579694474786147
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	4/514	55/9376	1.32663600990449	PLPP3/HEXA/ASAH1/DEGS1	0.585080302600749
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/514	23/9376	1.58619522923363	ENPEP/MME	0.677847588397581
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/514	23/9376	1.58619522923363	ATP1A4/ATP1B3	0.677847588397581
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	14/514	227/9376	1.125010713245	EGFR/ITGAV/ADCY2/AKAP13/CTNNB1/GNA12/MDM2/HRAS/CALR/MAP2K2/KRAS/PDIA3/CCND1/ADCY5	0.45917123397379
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/514	56/9376	1.3029460811562	CCND2/LRP2/CCND1/MGRN1	0.547586485440103
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/514	56/9376	1.3029460811562	HSPD1/HSPA1A/VCP/HSPA8	0.547586485440103
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/514	73/9376	1.24940035179361	MGST3/GSTA3/GSTP1/GSTA4/GSTO1	0.515167320855476
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/514	125/9376	1.16743968871595	ORMDL1/PRKCZ/GNA12/HRAS/MAP2K2/KRAS/ASAH1/DEGS1	0.453858421999168
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	13/514	212/9376	1.11856691872843	EGFR/PRKCZ/ADCY2/VAV3/CTNNB1/HRAS/MAP2K2/KRAS/RAPGEF1/PGF/CDH1/EFNA5/ADCY5	0.420523479102679
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/514	41/9376	1.33472525386732	GLDC/ALDH7A1/ALAS1	0.517278671250579
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/514	77/9376	1.18449643741473	GADD45G/EGFR/GADD45B/KRAS/CCND1	0.391486281459022
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/514	60/9376	1.21608300907912	PLCG2/HRAS/MAP2K2/KRAS	0.404373632314064
Organismal Systems	Nervous system	hsa04730	Long-term depression	4/514	60/9376	1.21608300907912	GNA12/HRAS/MAP2K2/KRAS	0.404373632314064
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/514	26/9376	1.4031727027836	PLA2G2A/ACAA1	0.495762089394064
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/514	26/9376	1.4031727027836	MAFA/RFX6	0.495762089394064
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/514	26/9376	1.4031727027836	SLC19A3/SLC19A1	0.495762089394064
NA	NA	hsa04081	Hormone signaling	13/514	219/9376	1.08281363822113	SLC40A1/ITGAV/CGA/ADCY2/GNA12/ADRB1/CSH2/GHR/GAST/PRLR/SLC16A2/IRS1/ADCY5	0.298640455921608
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/514	149/9376	1.10182017601128	PLCG2/EGFR/ADCY2/PLPP3/GNA12/HRAS/MAP2K2/KRAS/ADCY5	0.301715792118291
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/514	79/9376	1.15450918583461	MGST3/GSTA3/GSTP1/GSTA4/GSTO1	0.332122087609757
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	10/514	170/9376	1.07301441977569	AMOT/PRKCZ/NEDD4L/JAM3/NEDD4/MYH10/MARVELD3/CCND1/RAP2C/ARPC5L	0.231365680524302
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/514	28/9376	1.3029460811562	B3GNT5/B3GNT2	0.386621790335702
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/514	117/9376	1.09135654660947	BRD7/BRD8/RBBP7/YY1/SMARCA2/MBD3/BPTF	0.239470426683628
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/514	82/9376	1.11227104488944	MGST3/GSTA3/GSTP1/GSTA4/GSTO1	0.24590914598182
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/514	29/9376	1.25801690594392	FRMD6/TEAD3	0.335129273810094
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/514	173/9376	1.05440723330559	SLC25A5/HLA-DRA/SLC25A6/FDPS/HLA-DPB1/PABPN1/MAP2K2/HLA-DPA1/HLA-DRB1/TLR3	0.173946745373388
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/514	300/9376	1.03367055771725	GADD45G/EGFR/DUSP9/RASA1/GNA12/HSPA1A/HRAS/MAP3K4/GADD45B/MAP2K2/ERBB4/KRAS/HSPA8/PGF/EFNA5/DDIT3/ERBB3	0.142746352122319
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/514	83/9376	1.09887018892691	RBBP7/YY1/CBX4/AUTS2/AEBP2	0.217885217556486
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/514	120/9376	1.06407263294423	PLCG2/HRAS/MAP2K2/KRAS/RAPGEF1/KIDINS220/IRS1	0.170119009640574
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/514	66/9376	1.10553000825374	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DRB1	0.207192687762303
NA	NA	hsa03272	Virion - Hepatitis viruses	3/514	48/9376	1.14007782101167	EGFR/TSG101/CHMP4A	0.234313360273568
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/514	30/9376	1.21608300907912	GGH/SLC19A1	0.285476052557372
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/514	140/9376	1.04235686492496	ADCY2/HRAS/MAP2K2/KRAS/CCND1/PDE3B/CDH1/ADCY5	0.121603811797398
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/514	323/9376	1.0165399766296	PLCG2/CD44/EGFR/ABCB1/CCND2/PDCD4/DNMT1/MDM2/HRAS/MAP2K2/KRAS/DNMT3A/ST14/CCND1/EFNA5/IRS1/SOCS1/ERBB3	0.0728519561312138
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/514	31/9376	1.17685452491528	SEC11C/SPCS2	0.237524654394856
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/514	68/9376	1.07301441977569	HRAS/MAP2K2/KRAS/CCND1	0.145524539021461
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/514	51/9376	1.07301441977569	PLPP3/PLA2G2A/CHPT1	0.125913017239549
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/514	51/9376	1.07301441977569	PLCG2/ATP6V0B/ATP6V1C2	0.125913017239549
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	8/514	144/9376	1.01340250756593	CTNNB1/LPIN2/ACADVL/ALDH7A1/C1QA/C1QB/CCND1/C1QC	0.0390319936145033
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/514	14/9376	1.3029460811562	B3GNT2	0.273178403886287
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	6/514	108/9376	1.01340250756593	RBM8A/RANBP17/SAP18/DDX39B/UPF3B/TPR	0.0337369836833907
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/514	33/9376	1.10553000825374	GOT1/IDH2	0.146248389560504
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/514	90/9376	1.01340250756593	EGFR/HRAS/EML4/MAP2K2/KRAS	0.0307676481862936
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/514	91/9376	1.002266216274	PLCG2/VAV3/HRAS/MAP2K2/KRAS	0.00523157458035327
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/514	34/9376	1.07301441977569	POLR2J3/POLR2A	0.102713964033577
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/514	15/9376	1.21608300907912	HEXA	0.201700256627871
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/514	73/9376	0.999520281434891	MLLT1/TSG101/FURIN/CHMP4A	-0.000990918120901771
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	7/514	130/9376	0.982220891948518	EGFR/PRKCZ/ADCY2/HRAS/MAP2K2/KRAS/ADCY5	-0.0491593379921543
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/514	16/9376	1.14007782101167	GOT1	0.135049434270745
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/514	16/9376	1.14007782101167	HEXA	0.135049434270745
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/514	36/9376	1.01340250756593	GALNT11/C1GALT1	0.0194028353435516
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/514	36/9376	1.01340250756593	MCM5/RNASEH2C	0.0194028353435516
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/514	56/9376	0.977209560867148	TUSC3/ALG11/DDOST	-0.0411945796386132
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/514	37/9376	0.98601325060469	COMT/GOT1	-0.0205290471769361
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/514	17/9376	1.07301441977569	HSD17B4	0.0725637469663714
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/514	38/9376	0.960065533483514	PNP/QPRT	-0.0594037792361637
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/514	78/9376	0.935448468522398	PLCG2/ISYNA1/PIK3C2A/PPIP5K1	-0.137867025453934
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/514	78/9376	0.935448468522398	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DRB1	-0.137867025453934
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/514	156/9376	0.935448468522398	EGFR/CFLAR/CTNNB1/HRAS/MAP2K2/KRAS/CCND1/TLR3	-0.195796405140768
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	5/514	98/9376	0.930675772254427	PLCG2/VAV3/PLPP3/WASF2/ARPC5L	-0.166139239803511
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	5/514	98/9376	0.930675772254427	ATP2B1/ATP1A4/ATP1B3/ADCY2/ADCY5	-0.166139239803511
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/514	18/9376	1.01340250756593	MMAB	0.0137066750861155
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/514	99/9376	0.92127500687812	ITGB4/ITGAV/ITGB8/ITGB5/DAG1	-0.189639051819828
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/514	39/9376	0.935448468522398	GLDC/ALDH7A1	-0.0972828979492198
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	13/514	254/9376	0.933607034529244	PLCG2/ATP2B1/EGFR/MCOLN3/SLC25A5/ADCY2/TFEB/ADRB1/SLC25A6/CASQ1/ERBB4/ASPH/ERBB3	-0.258342118267884
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/514	158/9376	0.923607348667685	GADD45G/CDKN1C/CCND2/MDM2/TFDP2/GADD45B/MCM5/CCND1	-0.233218554703914
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/514	101/9376	0.903031937434989	PLCG2/PRKCZ/HRAS/KRAS/CCND1	-0.235957491804798
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/514	19/9376	0.960065533483514	HEXA	-0.041962146693624
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/514	19/9376	0.960065533483514	GLDC	-0.041962146693624
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/514	180/9376	0.912062256809339	HLA-DRA/HLA-DPB1/CALR/SRSF6/PDIA3/HLA-DPA1/HLA-DRB1/SRSF3/TLR3	-0.286888679765765
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/514	103/9376	0.885497336708096	CFLAR/C1QA/CALR/C1QB/C1QC	-0.281400843980837
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/514	20/9376	0.912062256809339	NPL	-0.0948083376755189
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/514	63/9376	0.868630720770799	ECHS1/HADHA/ALDH7A1	-0.251953627342986
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/514	63/9376	0.868630720770799	DDB1/POLR2J3/POLR2A	-0.251953627342986
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/514	43/9376	0.848430006334268	PLPP3/PLA2G2A	-0.239904366252828
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	10/514	205/9376	0.88981683591155	CCND2/DDB1/SND1/PMAIP1/PSMC1/MDM2/HRAS/DDX3X/KRAS/CCND1	-0.38413612257214
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/514	21/9376	0.868630720770799	CHST12	-0.145138587913745
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/514	65/9376	0.841903621670159	PLPP3/LPIN2/ALDH7A1	-0.30802201748488
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/514	65/9376	0.841903621670159	ADCY2/PBX1/ADCY5	-0.30802201748488
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/514	44/9376	0.829147506190308	HMGB1/MUTYH	-0.273565685009791
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/514	168/9376	0.868630720770799	SLC25A5/CFLAR/GLUL/HMGB1/SLC25A6/CHMP4A/SQSTM1/TLR3	-0.413777744097437
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/514	22/9376	0.829147506190308	ALDH7A1	-0.193212537727854
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/514	45/9376	0.810722006052745	ABCB1/ABCB8	-0.306509268393177
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/514	67/9376	0.816772170277019	ACSS1/LDHB/ALDH7A1	-0.362475492486569
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/514	67/9376	0.816772170277019	HRAS/MAP2K2/KRAS	-0.362475492486569
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/514	46/9376	0.793097614616816	MMAB/ALAS1	-0.338769978452357
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/514	110/9376	0.829147506190308	PLCG2/EGFR/LDHB/EGLN2/MAP2K2	-0.434083063836691
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/514	69/9376	0.793097614616816	ADRB1/PDE3B/ADCY5	-0.415419148252753
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/514	24/9376	0.760051880674449	GLCE	-0.283447118913198
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/514	91/9376	0.801812973019199	GABRE/ADCY2/PDE3B/ADCY5	-0.457516003395031
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	7/514	154/9376	0.829147506190308	GGH/MMAB/KMO/MOCS2/PDXK/QPRT/ALAS1	-0.514837826993966
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/514	154/9376	0.829147506190308	EGFR/ADCY2/HRAS/MAP2K2/KRAS/CCND1/ADCY5	-0.514837826993966
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/514	48/9376	0.760051880674449	ATP1A4/ATP1B3	-0.401370107876018
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/514	134/9376	0.816772170277019	ADCY2/GNA12/PLA2G2A/MAP2K2/MYH10/ADCY5	-0.514472516619824
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	9/514	196/9376	0.837608195028984	PLCG2/UBB/CTNNB1/HRAS/MAP2K2/KRAS/CD86/CCND1/TLR3	-0.553314598805211
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/514	93/9376	0.78456968327685	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DRB1	-0.502811779941305
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/514	49/9376	0.744540617803542	GALNT11/C1GALT1	-0.431767783348947
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/514	116/9376	0.786260566214947	PLCG2/VAV3/CTNNB1/JAM3/CDH5	-0.557839779707899
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/514	116/9376	0.786260566214947	SLC38A1/ADCY2/GLUL/SLC1A2/ADCY5	-0.557839779707899
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/514	28/9376	0.651473040578099	ATP6V1C2	-0.444792408331166
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/514	99/9376	0.737020005502496	PLCG2/ADCY2/TRPV2/ADCY5	-0.633487217037679
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/514	226/9376	0.807134740539238	ATP2B1/ATP1A4/CGA/ATP1B3/ADCY2/VAV3/ADRB1/MAP2K2/PDE3B/ADCY5	-0.70680400750191
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/514	78/9376	0.701586351391799	C1QA/C1QB/C1QC	-0.63734199865953
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/514	30/9376	0.608041504539559	PLA2G2A	-0.517832311421596
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/514	103/9376	0.708397869366476	LAMB4/LAMC2/ARG2/LAMA5	-0.716639100853871
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/514	31/9376	0.588427262457638	TKT	-0.55276319500407
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/514	31/9376	0.588427262457638	ALDH7A1	-0.55276319500407
NA	NA	hsa04981	Folate transport and metabolism	1/514	31/9376	0.588427262457638	SLC19A1	-0.55276319500407
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	11/514	253/9376	0.793097614616816	PLCG2/CD44/UBB/EGFR/MDM2/FOXO4/WASF2/SQSTM1/ARPC5L/CASP4/WIPI2	-0.803448872612101
Organismal Systems	Immune system	hsa04611	Platelet activation	5/514	126/9376	0.723858933975665	PLCG2/PRKCZ/ADCY2/VAMP8/ADCY5	-0.751530703329538
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/514	105/9376	0.694904576616639	PLCG2/GADD45G/CFLAR/GADD45B	-0.757126377566833
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/514	105/9376	0.694904576616639	PLCG2/MDM2/HRAS/KRAS	-0.757126377566833
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/514	32/9376	0.570038910505837	PMAIP1	-0.586731025660608
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/514	193/9376	0.756113788028467	PLCG2/PRKCZ/ADCY2/VAV3/HRAS/KRAS/CXCL9/ADCY5	-0.824470147914342
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/514	238/9376	0.766438871268352	PLCG2/EGFR/RASA1/FOXO4/PLA2G2A/HRAS/MAP2K2/KRAS/PGF/EFNA5	-0.878951257713097
NA	NA	hsa04382	Cornified envelope formation	9/514	217/9376	0.756549337445534	ITGB4/KRT23/LAMC2/S100A9/LAMA5/FURIN/ST14/ABHD5/EPHX2	-0.873812238498194
NA	NA	hsa04519	Cadherin signaling	18/514	404/9376	0.81272874369149	KRT23/EGFR/GABRE/VAV3/CTNNB1/HRAS/LRP5/CDH26/MAP2K2/KRAS/CDH5/DVL3/TEAD3/CDH3/CDH1/FZD6/PRICKLE2/ARPC5L	-0.926655907853196
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/514	154/9376	0.710697862448835	ATP2B1/ATP1A4/ATP1B3/ADCY2/ADRB1/ADCY5	-0.871767689896615
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/514	109/9376	0.669403491236212	MAP2K2/CD86/CXCL9/TLR3	-0.836071183858948
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/514	109/9376	0.669403491236212	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DRB1	-0.836071183858948
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/514	109/9376	0.669403491236212	PRKCZ/SLC27A2/PTPN1/IRS1	-0.836071183858948
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/514	110/9376	0.663318004952246	ADCY2/KRAS/PDE3B/ADCY5	-0.855404265341123
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/514	133/9376	0.685761095345367	PLCG2/VAV3/HRAS/MAP2K2/KRAS	-0.878983294345076
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/514	36/9376	0.506701253782966	AGL	-0.714149520225563
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/514	136/9376	0.670634012359808	CD46/CCND2/HSPA1A/HSPA8/CCND1	-0.931780339556065
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/514	181/9376	0.705462519079046	HSPD1/NFYB/ATP6V0B/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DRB1	-0.963618909211244
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/514	138/9376	0.660914678847347	VAV3/WASF2/MAP2K2/BAIAP2/ARPC5L	-0.966408806552607
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/514	115/9376	0.634478091693453	ADCY2/HRAS/KRAS/ADCY5	-0.949805577041843
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	4/514	115/9376	0.634478091693453	APP/HRAS/KRAS/ADCY5	-0.949805577041843
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/514	38/9376	0.480032766741757	HEXA	-0.77346766913138
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	6/514	163/9376	0.671456876178654	DDB1/HRAS/DDX3X/MAP2K2/KRAS/TLR3	-1.01903000912883
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/514	41/9376	0.444908417955775	GABRE	-0.857829018470269
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/514	70/9376	0.521178432462479	ACSL3/IRS1	-0.968372671825069
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/514	214/9376	0.681915706025674	PLCG2/DDB1/HRAS/CALR/MAP2K2/KRAS/PDIA3/AP1S3	-1.13358813945821
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/514	122/9376	0.598073611022517	VAV3/HRAS/MAP2K2/KRAS	-1.07612572614558
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/514	98/9376	0.558405463352656	PLCG2/PIK3C2A/PPIP5K1	-1.05830505446429
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/514	216/9376	0.675601671710621	HSPD1/OLR1/VAV3/HSPA1A/HRAS/KRAS/HSPA8/DDIT3	-1.16160660045525
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/514	44/9376	0.414573753095154	TAF6L	-0.937373102880338
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/514	44/9376	0.414573753095154	VAMP2	-0.937373102880338
NA	NA	hsa04082	Neuroactive ligand signaling	7/514	199/9376	0.641651838961344	GABRE/ADCY2/ADRB1/SLC1A2/P2RY6/OGFRL1/ADCY5	-1.23050300127819
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/514	128/9376	0.570038910505837	PNP/ADCY2/PDE3B/ADCY5	-1.1795369601737
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/514	200/9376	0.638443579766537	GNA12/TUBB4B/WASF2/MYH10/BAIAP2/ARPC5L/CASP4	-1.2447028903446
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/514	49/9376	0.372270308901771	ADCY5	-1.06096497586989
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/514	107/9376	0.511436779519255	LDHB/ADCY2/PDE3B	-1.2240454457146
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/514	50/9376	0.364824902723735	LRP1	-1.0845063125184
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/514	110/9376	0.497488503714185	BMP7/BMP4/RGMA	-1.27672546684555
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/514	187/9376	0.585280592604923	TXNIP/GABARAPL1/TRPV2/CARD16/GABARAPL2/CASP4	-1.37956561621125
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	4/514	142/9376	0.513837891160191	PLCG2/SIRPA/SQSTM1/SOCS1	-1.40582631732662
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/514	195/9376	0.561269081113439	PLCG2/SLC25A5/HMGB1/SLC25A6/MAP2K2/CASP4	-1.49098020834327
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/514	122/9376	0.448555208266888	CCND1/IRS1/HMGCR	-1.47644927829369
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/514	94/9376	0.388111598642272	S100A9/USP25	-1.43587518694776
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/514	62/9376	0.294213631228819	DVL3	-1.34277213155836
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/514	97/9376	0.376108147137872	ADCY2/ADCY5	-1.48746213475719
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/514	69/9376	0.264365871538939	ADCY5	-1.47700811909435
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/514	72/9376	0.253350626891483	DDX3X	-1.53161435111357
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/514	138/9376	0.396548807308408	ADCY2/SLK/ADCY5	-1.71986373506061
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	7/514	248/9376	0.514873854650433	CTNNB1/PIK3C2A/TUBB4B/HRAS/MAP2K2/ARPC5L/CASP4	-1.86463585350636
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9/514	298/9376	0.550910088005641	CSF3R/IL1RL1/BMP7/CSH2/BMP4/GHR/CXCL9/PRLR/CSF2RA	-1.8973509417986
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/514	85/9376	0.214602883955138	PNP	-1.75173682534985
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/514	86/9376	0.212107501583567	KCNK5	-1.76770446551655
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/514	191/9376	0.38201560494632	HRAS/KRAS/SLC29A3/ADCY5	-2.07804973175529
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/514	133/9376	0.274304438138147	COMT/ADCY5	-2.02990230111066
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/514	100/9376	0.182412451361868	CXCL9	-1.97949871273157
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/514	194/9376	0.282081110353404	TUBB4B/MYH10/KIF26B	-2.43337435122764
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/514	370/9376	0.443705962772111	CGA/GABRE/ADRB1/CSH2/P2RY6/OGFRL1/PAQR9/GHR/PRLR	-2.62930290012817
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/514	119/9376	0.15328777425367	CFLAR	-2.23859487062904
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/514	183/9376	0.0996789351704195	EIF6	-2.96207227467694