ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0015453 oxidoreduction-driven active transmembrane transporter activity 33/869 68/18639 0.485294117647059 10.4089724497394 3.73607268144e-26 3.90045987942336e-23 GO:0009055 electron transfer activity 38/869 116/18639 0.327586206896552 7.02632832030475 2.06925387080527e-22 1.08015052056035e-19 GO:0022853 active monoatomic ion transmembrane transporter activity 38/869 118/18639 0.322033898305085 6.90723800979111 4.13473055705976e-22 1.4388862338568e-19 GO:0008137 NADH dehydrogenase (ubiquinone) activity 23/869 41/18639 0.560975609756098 12.0322490106374 1.6356077737681e-20 4.26893628953475e-18 GO:0003954 NADH dehydrogenase activity 23/869 44/18639 0.522727272727273 11.2118683962758 1.42516787885916e-19 2.97575053105792e-17 GO:0015399 primary active transmembrane transporter activity 40/869 166/18639 0.240963855421687 5.16838354569024 3.95800162539172e-18 6.88692282818159e-16 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 24/869 58/18639 0.413793103448276 8.875362088806 2.31328798828816e-17 3.45010379967548e-15 GO:0015078 proton transmembrane transporter activity 41/869 185/18639 0.221621621621622 4.75351600161727 3.78494931655079e-17 4.93935885809879e-15 GO:0022804 active transmembrane transporter activity 61/869 457/18639 0.133479212253829 2.8629678218632 1.09258877894018e-13 1.26740298357061e-11 GO:0016651 oxidoreductase activity, acting on NAD(P)H 25/869 88/18639 0.284090909090909 6.09340673710639 1.35560132454348e-13 1.41524778282339e-11 GO:0003712 transcription coregulator activity 49/869 495/18639 0.098989898989899 2.12321372528507 5.7617087315389e-07 5.46838537793329e-05 GO:0004129 cytochrome-c oxidase activity 7/869 15/18639 0.466666666666667 10.0094361334868 2.16495182633516e-06 0.000188350808891159 GO:0016675 oxidoreductase activity, acting on a heme group of donors 7/869 16/18639 0.4375 9.38384637514384 3.69379583816278e-06 0.000296640219618611 GO:0001618 virus receptor activity 15/869 81/18639 0.185185185185185 3.97199846566935 4.32625147675233e-06 0.000322614752980674 GO:0140272 exogenous protein binding 15/869 82/18639 0.182926829268293 3.92355945999046 5.06957154912696e-06 0.000352842179819237 GO:0044389 ubiquitin-like protein ligase binding 34/869 322/18639 0.105590062111801 2.26477924936923 7.8744553147088e-06 0.000513808209284749 GO:0031625 ubiquitin protein ligase binding 32/869 302/18639 0.105960264900662 2.27271965187968 1.3460027906943e-05 0.000826604066755796 GO:0045296 cadherin binding 34/869 334/18639 0.101796407185629 2.18340993502064 1.7132486433946e-05 0.000993684213168867 GO:1901681 sulfur compound binding 29/869 275/18639 0.105454545454545 2.26187258081389 3.68023872197378e-05 0.00202219432933717 GO:0098631 cell adhesion mediator activity 13/869 76/18639 0.171052631578947 3.66887226697353 4.4965301673982e-05 0.00234718874738186 GO:0004300 enoyl-CoA hydratase activity 5/869 12/18639 0.416666666666667 8.93699654775604 0.000131085019771103 0.00651679812576341 GO:0017154 semaphorin receptor activity 5/869 13/18639 0.384615384615385 8.24953527485173 0.000204847707467387 0.00972095484527054 GO:0003713 transcription coactivator activity 25/869 256/18639 0.09765625 2.09460856588032 0.00040588658165948 0.0184237213588042 GO:0008201 heparin binding 19/869 172/18639 0.11046511627907 2.36934327080044 0.000434710895620188 0.0189099239594782 GO:0003714 transcription corepressor activity 21/869 204/18639 0.102941176470588 2.20796385297502 0.000577184445092409 0.024103222427059 GO:0015658 branched-chain amino acid transmembrane transporter activity 4/869 10/18639 0.4 8.5795166858458 0.000786205722450176 0.0315691836245378 GO:0098632 cell-cell adhesion mediator activity 9/869 55/18639 0.163636363636364 3.50980228057328 0.000921038347218401 0.0356134827591115 GO:0016829 lyase activity 20/869 200/18639 0.1 2.14487917146145 0.00110744217206922 0.0404080174492187 GO:0035615 clathrin adaptor activity 5/869 18/18639 0.277777777777778 5.95799769850403 0.00112244492914496 0.0404080174492187 GO:0015101 organic cation transmembrane transporter activity 11/869 81/18639 0.135802469135802 2.91279887482419 0.0013020019503791 0.0453096678731926 GO:0003735 structural constituent of ribosome 18/869 175/18639 0.102857142857143 2.20616143350321 0.00139736845642643 0.0470597635002967 GO:0008135 translation factor activity, RNA binding 11/869 83/18639 0.132530120481928 2.84261095012963 0.00159347709859375 0.0519871903416211 GO:0180051 translation factor activity 11/869 84/18639 0.130952380952381 2.80877034358047 0.00175804928888252 0.0556182865937379 GO:0008514 organic anion transmembrane transporter activity 24/869 269/18639 0.0892193308550186 1.91364684442657 0.00183818881031401 0.056443209351995 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 9/869 61/18639 0.147540983606557 3.1645758267464 0.00195888768175654 0.0568077427709396 GO:0016836 hydro-lyase activity 9/869 61/18639 0.147540983606557 3.1645758267464 0.00195888768175654 0.0568077427709396 GO:0140312 cargo adaptor activity 5/869 21/18639 0.238095238095238 5.10685517014631 0.00237324412998279 0.0657356386330536 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4/869 13/18639 0.307692307692308 6.59962821988139 0.00239267650196938 0.0657356386330536 GO:0016878 acid-thiol ligase activity 6/869 31/18639 0.193548387096774 4.15137904153829 0.00273100897233139 0.0712793341778493 GO:0070325 lipoprotein particle receptor binding 6/869 31/18639 0.193548387096774 4.15137904153829 0.00273100897233139 0.0712793341778493 GO:0008200 ion channel inhibitor activity 7/869 43/18639 0.162790697674419 3.49166376749538 0.00346836584003573 0.088316437487739 GO:0016835 carbon-oxygen lyase activity 10/869 79/18639 0.126582278481013 2.71503692590057 0.00360099155620879 0.089510361540047 GO:0050840 extracellular matrix binding 9/869 67/18639 0.134328358208955 2.88118097659001 0.00376966187348194 0.0899176079909642 GO:0008013 beta-catenin binding 12/869 106/18639 0.113207547169811 2.42816509976768 0.00384677674089564 0.0899176079909642 GO:0051087 protein-folding chaperone binding 14/869 134/18639 0.104477611940299 2.24091853734778 0.00394387537392515 0.0899176079909642 GO:0016248 channel inhibitor activity 7/869 44/18639 0.159090909090909 3.41230777277958 0.00396188694213061 0.0899176079909642 GO:0051082 unfolded protein binding 13/869 121/18639 0.107438016528926 2.30441563876024 0.00423144906296283 0.0922577106913514 GO:0030215 semaphorin receptor binding 5/869 24/18639 0.208333333333333 4.46849827387802 0.00441508618646495 0.0922577106913514 GO:0048027 mRNA 5'-UTR binding 5/869 24/18639 0.208333333333333 4.46849827387802 0.00441508618646495 0.0922577106913514 GO:0002020 protease binding 14/869 136/18639 0.102941176470588 2.20796385297502 0.00450498814332526 0.0922577106913514 GO:0141110 transporter inhibitor activity 7/869 45/18639 0.155555555555556 3.33647871116226 0.00450684218894533 0.0922577106913514 GO:0016874 ligase activity 16/869 167/18639 0.0958083832335329 2.05497405649001 0.00506569208958722 0.101548792700775 GO:0015645 fatty acid ligase activity 5/869 25/18639 0.2 4.2897583429229 0.00531043788621417 0.101548792700775 GO:0120515 fatty acid-CoA ligase activity 5/869 25/18639 0.2 4.2897583429229 0.00531043788621417 0.101548792700775 GO:0000062 fatty-acyl-CoA binding 4/869 16/18639 0.25 5.36219792865363 0.0054470616774362 0.101548792700775 GO:0005159 insulin-like growth factor receptor binding 4/869 16/18639 0.25 5.36219792865363 0.0054470616774362 0.101548792700775 GO:0050750 low-density lipoprotein particle receptor binding 5/869 26/18639 0.192307692307692 4.12476763742587 0.00632685746994713 0.115881389449558 GO:0016209 antioxidant activity 10/869 86/18639 0.116279069767442 2.49404554821099 0.00661813062121205 0.119126351181817 GO:1901567 fatty acid derivative binding 4/869 17/18639 0.235294117647059 5.04677452108576 0.0068637677889702 0.121453789350591 GO:0060590 ATPase regulator activity 7/869 49/18639 0.142857142857143 3.06411310208779 0.00726652371518454 0.121892233600284 GO:0001671 ATPase activator activity 5/869 27/18639 0.185185185185185 3.97199846566935 0.00747232083373389 0.121892233600284 GO:0004364 glutathione transferase activity 5/869 27/18639 0.185185185185185 3.97199846566935 0.00747232083373389 0.121892233600284 GO:0016405 CoA-ligase activity 5/869 27/18639 0.185185185185185 3.97199846566935 0.00747232083373389 0.121892233600284 GO:0023026 MHC class II protein complex binding 5/869 27/18639 0.185185185185185 3.97199846566935 0.00747232083373389 0.121892233600284 GO:0015179 L-amino acid transmembrane transporter activity 8/869 62/18639 0.129032258064516 2.76758602769219 0.00786370529981224 0.12605034869555 GO:0044183 protein folding chaperone 9/869 75/18639 0.12 2.57385500575374 0.00796870020489111 0.12605034869555 GO:0070064 proline-rich region binding 4/869 18/18639 0.222222222222222 4.76639815880322 0.00850414574892027 0.132460498786129 GO:0045499 chemorepellent activity 5/869 28/18639 0.178571428571429 3.83014137760973 0.00875457319563496 0.132460498786129 GO:0097718 disordered domain specific binding 5/869 28/18639 0.178571428571429 3.83014137760973 0.00875457319563496 0.132460498786129 GO:0003743 translation initiation factor activity 7/869 51/18639 0.137254901960784 2.9439518039667 0.00904063949169385 0.13456665812772 GO:0051540 metal cluster binding 9/869 77/18639 0.116883116883117 2.50700162898092 0.00942987991673217 0.13456665812772 GO:0032395 MHC class II receptor activity 3/869 10/18639 0.3 6.43463751438435 0.00947303229402344 0.13456665812772 GO:0070097 delta-catenin binding 3/869 10/18639 0.3 6.43463751438435 0.00947303229402344 0.13456665812772 GO:0005539 glycosaminoglycan binding 20/869 242/18639 0.0826446280991736 1.77262741443095 0.00966548584853057 0.13456665812772 GO:0061134 peptidase regulator activity 19/869 226/18639 0.084070796460177 1.80321700255609 0.00966714498043969 0.13456665812772 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 4/869 19/18639 0.210526315789474 4.51553509781358 0.0103811588668113 0.138947818678858 GO:0005520 insulin-like growth factor binding 4/869 19/18639 0.210526315789474 4.51553509781358 0.0103811588668113 0.138947818678858 GO:0120227 acyl-CoA binding 4/869 19/18639 0.210526315789474 4.51553509781358 0.0103811588668113 0.138947818678858 GO:0019838 growth factor binding 13/869 136/18639 0.0955882352941176 2.05025214919109 0.0110729697832777 0.144975382039863 GO:0015175 neutral L-amino acid transmembrane transporter activity 6/869 41/18639 0.146341463414634 3.13884756799237 0.0112480899858514 0.144975382039863 GO:0016877 ligase activity, forming carbon-sulfur bonds 6/869 41/18639 0.146341463414634 3.13884756799237 0.0112480899858514 0.144975382039863 GO:0015173 aromatic amino acid transmembrane transporter activity 3/869 11/18639 0.272727272727273 5.84967046762214 0.0125791591739725 0.156340978305087 GO:0019107 myristoyltransferase activity 3/869 11/18639 0.272727272727273 5.84967046762214 0.0125791591739725 0.156340978305087 GO:0050786 RAGE receptor binding 3/869 11/18639 0.272727272727273 5.84967046762214 0.0125791591739725 0.156340978305087 GO:0031406 carboxylic acid binding 16/869 187/18639 0.0855614973262032 1.83519073494028 0.0142970912337898 0.175601920565606 GO:0046943 carboxylic acid transmembrane transporter activity 16/869 188/18639 0.0851063829787234 1.82542908209485 0.014976080519778 0.181802651891258 GO:0140030 modification-dependent protein binding 15/869 173/18639 0.0867052023121387 1.85972182496658 0.015524455824364 0.183823957858899 GO:0005342 organic acid transmembrane transporter activity 16/869 189/18639 0.0846560846560847 1.81577072716313 0.0156798299756893 0.183823957858899 GO:0043177 organic acid binding 16/869 189/18639 0.0846560846560847 1.81577072716313 0.0156798299756893 0.183823957858899 GO:0003995 acyl-CoA dehydrogenase activity 3/869 12/18639 0.25 5.36219792865363 0.0161990460948455 0.183823957858899 GO:0005078 MAP-kinase scaffold activity 3/869 12/18639 0.25 5.36219792865363 0.0161990460948455 0.183823957858899 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 3/869 12/18639 0.25 5.36219792865363 0.0161990460948455 0.183823957858899 GO:0019902 phosphatase binding 16/869 190/18639 0.0842105263157895 1.80621403912543 0.0164089061256447 0.184203204249173 GO:0019903 protein phosphatase binding 13/869 144/18639 0.0902777777777778 1.93634925201381 0.0172071100980305 0.189514695368383 GO:0042605 peptide antigen binding 6/869 45/18639 0.133333333333333 2.85983889528193 0.017426638654564 0.189514695368383 GO:0051539 4 iron, 4 sulfur cluster binding 6/869 45/18639 0.133333333333333 2.85983889528193 0.017426638654564 0.189514695368383 GO:0005178 integrin binding 14/869 161/18639 0.0869565217391304 1.86511232300996 0.0185422935287194 0.199568602515289 GO:0030276 clathrin binding 6/869 46/18639 0.130434782608696 2.79766848451493 0.0192746614936402 0.204294259085679 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/869 59/18639 0.11864406779661 2.54477189834409 0.0193727314650213 0.204294259085679 GO:0090482 vitamin transmembrane transporter activity 5/869 34/18639 0.147058823529412 3.1542340756786 0.0197152007975608 0.205506372571949 GO:0031994 insulin-like growth factor I binding 3/869 13/18639 0.230769230769231 4.94972116491104 0.0203409569727084 0.205506372571949 GO:0061459 L-arginine transmembrane transporter activity 3/869 13/18639 0.230769230769231 4.94972116491104 0.0203409569727084 0.205506372571949 GO:0070700 BMP receptor binding 3/869 13/18639 0.230769230769231 4.94972116491104 0.0203409569727084 0.205506372571949 GO:0005158 insulin receptor binding 4/869 23/18639 0.173913043478261 3.73022464601991 0.0204718991834126 0.205506372571949 GO:0043495 protein-membrane adaptor activity 6/869 47/18639 0.127659574468085 2.73814362314228 0.0212518158476835 0.211303768999824 GO:0003725 double-stranded RNA binding 8/869 75/18639 0.106666666666667 2.28787111622555 0.0232186879139682 0.228682171530027 GO:0051536 iron-sulfur cluster binding 8/869 76/18639 0.105263157894737 2.25776754890679 0.0249295928432671 0.243238270358606 GO:0061135 endopeptidase regulator activity 15/869 184/18639 0.0815217391304348 1.74854280282183 0.0255440594725479 0.246925908234629 GO:0016922 nuclear receptor binding 12/869 137/18639 0.0875912408759124 1.87872628157207 0.0265500388876494 0.254295785309229 GO:0005507 copper ion binding 7/869 63/18639 0.111111111111111 2.38319907940161 0.0268174895917265 0.254522355761477 GO:0023023 MHC protein complex binding 5/869 37/18639 0.135135135135135 2.8984853668398 0.0275650124782307 0.256945294886365 GO:0042805 actinin binding 5/869 37/18639 0.135135135135135 2.8984853668398 0.0275650124782307 0.256945294886365 GO:0004467 long-chain fatty acid-CoA ligase activity 3/869 15/18639 0.2 4.2897583429229 0.0302004633010126 0.271804169709113 GO:0005041 low-density lipoprotein particle receptor activity 3/869 15/18639 0.2 4.2897583429229 0.0302004633010126 0.271804169709113 GO:0033130 acetylcholine receptor binding 3/869 15/18639 0.2 4.2897583429229 0.0302004633010126 0.271804169709113 GO:0048531 beta-1,3-galactosyltransferase activity 3/869 15/18639 0.2 4.2897583429229 0.0302004633010126 0.271804169709113 GO:0016597 amino acid binding 6/869 51/18639 0.117647058823529 2.52338726054288 0.0305193121164676 0.272326169654634 GO:0042562 hormone binding 9/869 94/18639 0.0957446808510638 2.05360771735671 0.0311185529151182 0.275320078333758 GO:0004867 serine-type endopeptidase inhibitor activity 9/869 95/18639 0.0947368421052632 2.03199079401611 0.0330126128747064 0.289623259169693 GO:0001530 lipopolysaccharide binding 5/869 41/18639 0.121951219512195 2.6157063066603 0.0407559955696212 0.354577161455705 GO:0051117 ATPase binding 8/869 84/18639 0.0952380952380952 2.04274206805852 0.0418639652449711 0.35765552762498 GO:0008429 phosphatidylethanolamine binding 3/869 17/18639 0.176470588235294 3.78508089081432 0.0421375765305293 0.35765552762498 GO:0038191 neuropilin binding 3/869 17/18639 0.176470588235294 3.78508089081432 0.0421375765305293 0.35765552762498 GO:0043236 laminin binding 4/869 29/18639 0.137931034482759 2.958454029602 0.0441293750055437 0.371540866982159 GO:0048487 beta-tubulin binding 5/869 42/18639 0.119047619047619 2.55342758507315 0.0445583021066695 0.372150939194903 GO:0140299 molecular sensor activity 7/869 71/18639 0.0985915492957746 2.11466960566622 0.0470557514900859 0.374235367149396 GO:0015291 secondary active transmembrane transporter activity 20/869 287/18639 0.0696864111498258 1.4946893180916 0.0483457012079054 0.374235367149396 GO:0015171 amino acid transmembrane transporter activity 9/869 102/18639 0.0882352941176471 1.89254044540716 0.0485283260762794 0.374235367149396 GO:0004601 peroxidase activity 6/869 57/18639 0.105263157894737 2.25776754890679 0.0487913255156026 0.374235367149396 GO:0016504 peptidase activator activity 6/869 57/18639 0.105263157894737 2.25776754890679 0.0487913255156026 0.374235367149396 GO:0003746 translation elongation factor activity 3/869 18/18639 0.166666666666667 3.57479861910242 0.0488642626868511 0.374235367149396 GO:0030228 lipoprotein particle receptor activity 3/869 18/18639 0.166666666666667 3.57479861910242 0.0488642626868511 0.374235367149396 GO:0034185 apolipoprotein binding 3/869 18/18639 0.166666666666667 3.57479861910242 0.0488642626868511 0.374235367149396 GO:0050811 GABA receptor binding 3/869 18/18639 0.166666666666667 3.57479861910242 0.0488642626868511 0.374235367149396 GO:0070628 proteasome binding 3/869 18/18639 0.166666666666667 3.57479861910242 0.0488642626868511 0.374235367149396 GO:1990381 ubiquitin-specific protease binding 3/869 18/18639 0.166666666666667 3.57479861910242 0.0488642626868511 0.374235367149396 GO:0033612 receptor serine/threonine kinase binding 4/869 30/18639 0.133333333333333 2.85983889528193 0.0491094303634744 0.374235367149396 GO:0005518 collagen binding 7/869 72/18639 0.0972222222222222 2.08529919447641 0.0501220071190696 0.379183879944266 GO:0015297 antiporter activity 11/869 135/18639 0.0814814814814815 1.74767932489451 0.0509822144460831 0.382916776127416 GO:0030414 peptidase inhibitor activity 13/869 169/18639 0.0769230769230769 1.64990705497035 0.05292859841149 0.394696119582825 GO:0005346 purine ribonucleotide transmembrane transporter activity 3/869 19/18639 0.157894736842105 3.38665132336018 0.0560798446531086 0.395781197254851 GO:0008301 DNA binding, bending 3/869 19/18639 0.157894736842105 3.38665132336018 0.0560798446531086 0.395781197254851 GO:0031420 alkali metal ion binding 3/869 19/18639 0.157894736842105 3.38665132336018 0.0560798446531086 0.395781197254851 GO:0034987 immunoglobulin receptor binding 3/869 19/18639 0.157894736842105 3.38665132336018 0.0560798446531086 0.395781197254851 GO:0042577 lipid phosphatase activity 3/869 19/18639 0.157894736842105 3.38665132336018 0.0560798446531086 0.395781197254851 GO:0070003 threonine-type peptidase activity 3/869 19/18639 0.157894736842105 3.38665132336018 0.0560798446531086 0.395781197254851 GO:0015459 potassium channel regulator activity 6/869 59/18639 0.101694915254237 2.18123305572351 0.0561069130208026 0.395781197254851 GO:0031593 polyubiquitin modification-dependent protein binding 6/869 59/18639 0.101694915254237 2.18123305572351 0.0561069130208026 0.395781197254851 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4/869 32/18639 0.125 2.68109896432681 0.0599555654467071 0.414826890994246 GO:0004714 transmembrane receptor protein tyrosine kinase activity 6/869 60/18639 0.1 2.14487917146145 0.059998908563344 0.414826890994246 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 6/869 60/18639 0.1 2.14487917146145 0.059998908563344 0.414826890994246 GO:0030295 protein kinase activator activity 11/869 139/18639 0.079136690647482 1.69738639468172 0.0604396913909929 0.415125248764451 GO:0016408 C-acyltransferase activity 3/869 20/18639 0.15 3.21731875719217 0.0637692469477626 0.434192160539595 GO:0015026 coreceptor activity 6/869 61/18639 0.0983606557377049 2.10971721783093 0.0640475026083311 0.434192160539595 GO:0005496 steroid binding 9/869 108/18639 0.0833333333333333 1.78739930955121 0.0651505184972523 0.438820266523428 GO:0030296 protein tyrosine kinase activator activity 4/869 33/18639 0.121212121212121 2.59985354116539 0.065815993912896 0.44046088234015 GO:0033218 amide binding 17/869 247/18639 0.0688259109311741 1.47623262813136 0.0709266275294139 0.449530829328295 GO:0019199 transmembrane receptor protein kinase activity 7/869 78/18639 0.0897435897435897 1.92489156413207 0.0711355878919606 0.449530829328295 GO:0099106 ion channel regulator activity 12/869 160/18639 0.075 1.60865937859609 0.0712028311582891 0.449530829328295 GO:0016879 ligase activity, forming carbon-nitrogen bonds 5/869 48/18639 0.104166666666667 2.23424913693901 0.0716859986525562 0.449530829328295 GO:0032266 phosphatidylinositol-3-phosphate binding 5/869 48/18639 0.104166666666667 2.23424913693901 0.0716859986525562 0.449530829328295 GO:0015174 basic amino acid transmembrane transporter activity 3/869 21/18639 0.142857142857143 3.06411310208779 0.0719156421436492 0.449530829328295 GO:0051010 microtubule plus-end binding 3/869 21/18639 0.142857142857143 3.06411310208779 0.0719156421436492 0.449530829328295 GO:1901682 sulfur compound transmembrane transporter activity 6/869 63/18639 0.0952380952380952 2.04274206805852 0.0726143209131351 0.449530829328295 GO:0019955 cytokine binding 11/869 144/18639 0.0763888888888889 1.63844936708861 0.0737910051636335 0.449530829328295 GO:0004866 endopeptidase inhibitor activity 12/869 161/18639 0.0745341614906832 1.59866770543711 0.073849735252654 0.449530829328295 GO:0005131 growth hormone receptor binding 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0005345 purine nucleobase transmembrane transporter activity 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0015203 polyamine transmembrane transporter activity 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0015643 toxic substance binding 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0019911 structural constituent of myelin sheath 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0031956 medium-chain fatty acid-CoA ligase activity 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0031957 very long-chain fatty acid-CoA ligase activity 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0042975 peroxisome proliferator activated receptor binding 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 2/869 10/18639 0.2 4.2897583429229 0.0762135601447397 0.449530829328295 GO:0016229 steroid dehydrogenase activity 4/869 35/18639 0.114285714285714 2.45129048167023 0.0783909503059758 0.455701148871141 GO:0035591 signaling adaptor activity 10/869 129/18639 0.0775193798449612 1.66269703214066 0.0792610952598193 0.455701148871141 GO:0008093 cytoskeletal anchor activity 3/869 22/18639 0.136363636363636 2.92483523381107 0.0805007435957385 0.455701148871141 GO:0061133 endopeptidase activator activity 3/869 22/18639 0.136363636363636 2.92483523381107 0.0805007435957385 0.455701148871141 GO:0070034 telomerase RNA binding 3/869 22/18639 0.136363636363636 2.92483523381107 0.0805007435957385 0.455701148871141 GO:0140035 ubiquitin-like protein reader activity 3/869 22/18639 0.136363636363636 2.92483523381107 0.0805007435957385 0.455701148871141 GO:0140517 protein-RNA adaptor activity 3/869 22/18639 0.136363636363636 2.92483523381107 0.0805007435957385 0.455701148871141 GO:0120013 lipid transfer activity 6/869 65/18639 0.0923076923076923 1.97988846596442 0.0818044981354405 0.455701148871141 GO:0019209 kinase activator activity 11/869 148/18639 0.0743243243243243 1.59416695176189 0.0857216617586205 0.455701148871141 GO:0031072 heat shock protein binding 10/869 131/18639 0.0763358778625954 1.63731234462706 0.0857777948674895 0.455701148871141 GO:0005021 vascular endothelial growth factor receptor activity 5/869 51/18639 0.0980392156862745 2.10282271711907 0.087993568196497 0.455701148871141 GO:0000295 adenine nucleotide transmembrane transporter activity 3/869 23/18639 0.130434782608696 2.79766848451493 0.0895050702575873 0.455701148871141 GO:0004602 glutathione peroxidase activity 3/869 23/18639 0.130434782608696 2.79766848451493 0.0895050702575873 0.455701148871141 GO:0008171 O-methyltransferase activity 3/869 23/18639 0.130434782608696 2.79766848451493 0.0895050702575873 0.455701148871141 GO:0017134 fibroblast growth factor binding 3/869 23/18639 0.130434782608696 2.79766848451493 0.0895050702575873 0.455701148871141 GO:0070577 lysine-acetylated histone binding 3/869 23/18639 0.130434782608696 2.79766848451493 0.0895050702575873 0.455701148871141 GO:0000099 sulfur amino acid transmembrane transporter activity 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0004016 adenylate cyclase activity 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0008271 secondary active sulfate transmembrane transporter activity 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0008432 JUN kinase binding 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0015205 nucleobase transmembrane transporter activity 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0015217 ADP transmembrane transporter activity 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0032050 clathrin heavy chain binding 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0032794 GTPase activating protein binding 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0034056 estrogen response element binding 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0042608 T cell receptor binding 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0045294 alpha-catenin binding 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0047676 arachidonate-CoA ligase activity 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0070990 snRNP binding 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0140031 phosphorylation-dependent protein binding 2/869 11/18639 0.181818181818182 3.89978031174809 0.0903545381382435 0.455701148871141 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6/869 67/18639 0.0895522388059701 1.92078731772667 0.0916112061235699 0.459817784581764 GO:0005080 protein kinase C binding 5/869 52/18639 0.0961538461538462 2.06238381871293 0.0938236491155665 0.46575567999104 GO:0030159 signaling receptor complex adaptor activity 5/869 52/18639 0.0961538461538462 2.06238381871293 0.0938236491155665 0.46575567999104 GO:0016247 channel regulator activity 12/869 168/18639 0.0714285714285714 1.53205655104389 0.0941326134847792 0.46575567999104 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/869 24/18639 0.125 2.68109896432681 0.0989081857539853 0.480364992283008 GO:0070840 dynein complex binding 3/869 24/18639 0.125 2.68109896432681 0.0989081857539853 0.480364992283008 GO:0140033 acetylation-dependent protein binding 3/869 24/18639 0.125 2.68109896432681 0.0989081857539853 0.480364992283008 GO:0005109 frizzled binding 4/869 38/18639 0.105263157894737 2.25776754890679 0.099303928561746 0.480364992283008 GO:0017046 peptide hormone binding 5/869 53/18639 0.0943396226415094 2.02347091647307 0.0998459801967554 0.480364992283008 GO:1901505 carbohydrate derivative transmembrane transporter activity 5/869 53/18639 0.0943396226415094 2.02347091647307 0.0998459801967554 0.480364992283008 GO:0141108 transporter regulator activity 12/869 170/18639 0.0705882352941176 1.51403235632573 0.100494273022226 0.481266151537633 GO:0005049 nuclear export signal receptor activity 2/869 12/18639 0.166666666666667 3.57479861910242 0.105185636546923 0.481921955836636 GO:0008179 adenylate cyclase binding 2/869 12/18639 0.166666666666667 3.57479861910242 0.105185636546923 0.481921955836636 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/869 12/18639 0.166666666666667 3.57479861910242 0.105185636546923 0.481921955836636 GO:0008504 monoamine transmembrane transporter activity 2/869 12/18639 0.166666666666667 3.57479861910242 0.105185636546923 0.481921955836636 GO:0017166 vinculin binding 2/869 12/18639 0.166666666666667 3.57479861910242 0.105185636546923 0.481921955836636 GO:0042301 phosphate ion binding 2/869 12/18639 0.166666666666667 3.57479861910242 0.105185636546923 0.481921955836636 GO:0045295 gamma-catenin binding 2/869 12/18639 0.166666666666667 3.57479861910242 0.105185636546923 0.481921955836636 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 2/869 12/18639 0.166666666666667 3.57479861910242 0.105185636546923 0.481921955836636 GO:0015485 cholesterol binding 5/869 54/18639 0.0925925925925926 1.98599923283468 0.106057118737839 0.481921955836636 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/869 54/18639 0.0925925925925926 1.98599923283468 0.106057118737839 0.481921955836636 GO:0051287 NAD binding 5/869 54/18639 0.0925925925925926 1.98599923283468 0.106057118737839 0.481921955836636 GO:0050660 flavin adenine dinucleotide binding 7/869 86/18639 0.0813953488372093 1.74583188374769 0.106170545826079 0.481921955836636 GO:0000030 mannosyltransferase activity 3/869 25/18639 0.12 2.57385500575374 0.108688913726768 0.487000969659852 GO:0015662 P-type ion transporter activity 3/869 25/18639 0.12 2.57385500575374 0.108688913726768 0.487000969659852 GO:0140358 P-type transmembrane transporter activity 3/869 25/18639 0.12 2.57385500575374 0.108688913726768 0.487000969659852 GO:0003823 antigen binding 12/869 174/18639 0.0689655172413793 1.479227014801 0.113970680409667 0.508484574135438 GO:0140662 ATP-dependent protein folding chaperone 4/869 40/18639 0.1 2.14487917146145 0.114531999745932 0.50881450099895 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 9/869 122/18639 0.0737704918032787 1.5822879133732 0.1164508176844 0.515146837553026 GO:0008143 poly(A) binding 3/869 26/18639 0.115384615384615 2.47486058245552 0.118825531329983 0.516060931838981 GO:0015216 purine nucleotide transmembrane transporter activity 3/869 26/18639 0.115384615384615 2.47486058245552 0.118825531329983 0.516060931838981 GO:0030247 polysaccharide binding 3/869 26/18639 0.115384615384615 2.47486058245552 0.118825531329983 0.516060931838981 GO:0050681 nuclear androgen receptor binding 3/869 26/18639 0.115384615384615 2.47486058245552 0.118825531329983 0.516060931838981 GO:0016887 ATP hydrolysis activity 25/869 417/18639 0.0599520383693046 1.28589878384979 0.119482359443993 0.516060931838981 GO:0005172 vascular endothelial growth factor receptor binding 2/869 13/18639 0.153846153846154 3.29981410994069 0.120611941924053 0.516060931838981 GO:0030955 potassium ion binding 2/869 13/18639 0.153846153846154 3.29981410994069 0.120611941924053 0.516060931838981 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/869 13/18639 0.153846153846154 3.29981410994069 0.120611941924053 0.516060931838981 GO:0017080 sodium channel regulator activity 4/869 41/18639 0.0975609756097561 2.09256504532824 0.122507783981209 0.517806180066325 GO:0042169 SH2 domain binding 4/869 41/18639 0.0975609756097561 2.09256504532824 0.122507783981209 0.517806180066325 GO:0061650 ubiquitin-like protein conjugating enzyme activity 4/869 41/18639 0.0975609756097561 2.09256504532824 0.122507783981209 0.517806180066325 GO:0043539 protein serine/threonine kinase activator activity 6/869 73/18639 0.0821917808219178 1.76291438750256 0.124606831777526 0.524554566031199 GO:0015932 nucleobase-containing compound transmembrane transporter activity 5/869 57/18639 0.087719298245614 1.88147295742232 0.125784208524446 0.527384392367555 GO:0005543 phospholipid binding 29/869 497/18639 0.0583501006036217 1.25153915437388 0.126800673919707 0.529519614288697 GO:0042056 chemoattractant activity 4/869 42/18639 0.0952380952380952 2.04274206805852 0.130712992599581 0.543682726191088 GO:0016853 isomerase activity 12/869 180/18639 0.0666666666666667 1.42991944764097 0.136041360820071 0.554684403123846 GO:0005347 ATP transmembrane transporter activity 2/869 14/18639 0.142857142857143 3.06411310208779 0.136545873182786 0.554684403123846 GO:0008195 phosphatidate phosphatase activity 2/869 14/18639 0.142857142857143 3.06411310208779 0.136545873182786 0.554684403123846 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/869 14/18639 0.142857142857143 3.06411310208779 0.136545873182786 0.554684403123846 GO:0042813 Wnt receptor activity 2/869 14/18639 0.142857142857143 3.06411310208779 0.136545873182786 0.554684403123846 GO:0071933 Arp2/3 complex binding 2/869 14/18639 0.142857142857143 3.06411310208779 0.136545873182786 0.554684403123846 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 21/869 349/18639 0.0601719197707736 1.29061497423182 0.140049410763574 0.55817274094103 GO:0046875 ephrin receptor binding 3/869 28/18639 0.107142857142857 2.29808482656584 0.14007783345455 0.55817274094103 GO:0046966 nuclear thyroid hormone receptor binding 3/869 28/18639 0.107142857142857 2.29808482656584 0.14007783345455 0.55817274094103 GO:0051019 mitogen-activated protein kinase binding 3/869 28/18639 0.107142857142857 2.29808482656584 0.14007783345455 0.55817274094103 GO:0051393 alpha-actinin binding 3/869 28/18639 0.107142857142857 2.29808482656584 0.14007783345455 0.55817274094103 GO:0003724 RNA helicase activity 6/869 77/18639 0.0779220779220779 1.67133441932061 0.149401724232645 0.580489456411164 GO:0106222 lncRNA binding 3/869 29/18639 0.103448275862069 2.2188405222015 0.151148809429435 0.580489456411164 GO:0000774 adenyl-nucleotide exchange factor activity 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0010181 FMN binding 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0015116 sulfate transmembrane transporter activity 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0031386 protein tag activity 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0042809 nuclear vitamin D receptor binding 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0050700 CARD domain binding 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0051371 muscle alpha-actinin binding 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0061578 K63-linked deubiquitinase activity 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0140776 protein-containing complex destabilizing activity 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0141047 molecular tag activity 2/869 15/18639 0.133333333333333 2.85983889528193 0.152906705472289 0.580489456411164 GO:0005201 extracellular matrix structural constituent 11/869 168/18639 0.0654761904761905 1.40438517179024 0.16193176384946 0.606149320666597 GO:0015215 nucleotide transmembrane transporter activity 3/869 30/18639 0.1 2.14487917146145 0.162486518214542 0.606149320666597 GO:0051721 protein phosphatase 2A binding 3/869 30/18639 0.1 2.14487917146145 0.162486518214542 0.606149320666597 GO:0008186 ATP-dependent activity, acting on RNA 6/869 79/18639 0.0759493670886076 1.62902215554034 0.162568783320543 0.606149320666597 GO:0046332 SMAD binding 6/869 79/18639 0.0759493670886076 1.62902215554034 0.162568783320543 0.606149320666597 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 9/869 132/18639 0.0681818181818182 1.46241761690553 0.163518694189649 0.607521411864744 GO:0004857 enzyme inhibitor activity 24/869 416/18639 0.0576923076923077 1.23743029122776 0.16621944113839 0.615365590597445 GO:0003688 DNA replication origin binding 2/869 16/18639 0.125 2.68109896432681 0.169620122432244 0.619172754612806 GO:0016722 oxidoreductase activity, acting on metal ions 2/869 16/18639 0.125 2.68109896432681 0.169620122432244 0.619172754612806 GO:0022858 alanine transmembrane transporter activity 2/869 16/18639 0.125 2.68109896432681 0.169620122432244 0.619172754612806 GO:0140327 flippase activity 2/869 16/18639 0.125 2.68109896432681 0.169620122432244 0.619172754612806 GO:0042626 ATPase-coupled transmembrane transporter activity 7/869 98/18639 0.0714285714285714 1.53205655104389 0.172836362629528 0.624494099520111 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/869 31/18639 0.0967741935483871 2.07568952076915 0.174068757624859 0.624494099520111 GO:0005452 solute:inorganic anion antiporter activity 3/869 31/18639 0.0967741935483871 2.07568952076915 0.174068757624859 0.624494099520111 GO:0017147 Wnt-protein binding 3/869 31/18639 0.0967741935483871 2.07568952076915 0.174068757624859 0.624494099520111 GO:0072349 modified amino acid transmembrane transporter activity 3/869 31/18639 0.0967741935483871 2.07568952076915 0.174068757624859 0.624494099520111 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 14/869 229/18639 0.0611353711790393 1.31127984281486 0.183531052990209 0.645129066916495 GO:0043130 ubiquitin binding 7/869 100/18639 0.07 1.50141542002301 0.18540596910502 0.645129066916495 GO:0019843 rRNA binding 5/869 65/18639 0.0769230769230769 1.64990705497035 0.185570909532715 0.645129066916495 GO:0038024 cargo receptor activity 5/869 65/18639 0.0769230769230769 1.64990705497035 0.185570909532715 0.645129066916495 GO:0008378 galactosyltransferase activity 3/869 32/18639 0.09375 2.01082422324511 0.185873570608805 0.645129066916495 GO:0031369 translation initiation factor binding 3/869 32/18639 0.09375 2.01082422324511 0.185873570608805 0.645129066916495 GO:0070717 poly-purine tract binding 3/869 32/18639 0.09375 2.01082422324511 0.185873570608805 0.645129066916495 GO:0004659 prenyltransferase activity 2/869 17/18639 0.117647058823529 2.52338726054288 0.186617795219139 0.645129066916495 GO:0005092 GDP-dissociation inhibitor activity 2/869 17/18639 0.117647058823529 2.52338726054288 0.186617795219139 0.645129066916495 GO:0032183 SUMO binding 2/869 17/18639 0.117647058823529 2.52338726054288 0.186617795219139 0.645129066916495 GO:0048038 quinone binding 2/869 17/18639 0.117647058823529 2.52338726054288 0.186617795219139 0.645129066916495 GO:0042277 peptide binding 15/869 249/18639 0.0602409638554217 1.29209588642256 0.187564308363835 0.646261181293214 GO:0030165 PDZ domain binding 6/869 83/18639 0.072289156626506 1.55051506370707 0.190302134663287 0.653537594041026 GO:0032182 ubiquitin-like protein binding 8/869 120/18639 0.0666666666666667 1.42991944764097 0.197443832357334 0.674834803318953 GO:0016500 protein-hormone receptor activity 5/869 67/18639 0.0746268656716418 1.60065609810556 0.201912119945831 0.674834803318953 GO:0005006 epidermal growth factor receptor activity 4/869 50/18639 0.08 1.71590333716916 0.203450183266478 0.674834803318953 GO:0015605 organophosphate ester transmembrane transporter activity 4/869 50/18639 0.08 1.71590333716916 0.203450183266478 0.674834803318953 GO:0000400 four-way junction DNA binding 2/869 18/18639 0.111111111111111 2.38319907940161 0.203836986785675 0.674834803318953 GO:0008525 phosphatidylcholine transporter activity 2/869 18/18639 0.111111111111111 2.38319907940161 0.203836986785675 0.674834803318953 GO:0017075 syntaxin-1 binding 2/869 18/18639 0.111111111111111 2.38319907940161 0.203836986785675 0.674834803318953 GO:0031690 adrenergic receptor binding 2/869 18/18639 0.111111111111111 2.38319907940161 0.203836986785675 0.674834803318953 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/869 18/18639 0.111111111111111 2.38319907940161 0.203836986785675 0.674834803318953 GO:0098641 cadherin binding involved in cell-cell adhesion 2/869 18/18639 0.111111111111111 2.38319907940161 0.203836986785675 0.674834803318953 GO:1901611 phosphatidylglycerol binding 2/869 18/18639 0.111111111111111 2.38319907940161 0.203836986785675 0.674834803318953 GO:0140297 DNA-binding transcription factor binding 27/869 488/18639 0.055327868852459 1.1867159350299 0.204260342767039 0.674834803318953 GO:0005319 lipid transporter activity 11/869 178/18639 0.0617977528089888 1.32548712843123 0.209563801203431 0.685969688471139 GO:0051427 hormone receptor binding 3/869 34/18639 0.0882352941176471 1.89254044540716 0.210064802015505 0.685969688471139 GO:0032934 sterol binding 5/869 68/18639 0.0735294117647059 1.5771170378393 0.210258908343644 0.685969688471139 GO:1990841 promoter-specific chromatin binding 5/869 68/18639 0.0735294117647059 1.5771170378393 0.210258908343644 0.685969688471139 GO:0019887 protein kinase regulator activity 15/869 255/18639 0.0588235294117647 1.26169363027144 0.21213823697662 0.68994492026041 GO:0016830 carbon-carbon lyase activity 4/869 51/18639 0.0784313725490196 1.68225817369525 0.213276278166051 0.691492032314773 GO:0002039 p53 binding 5/869 69/18639 0.072463768115942 1.55426026917496 0.218714773323724 0.701496167795339 GO:0008381 mechanosensitive monoatomic ion channel activity 2/869 19/18639 0.105263157894737 2.25776754890679 0.221220179977742 0.701496167795339 GO:0030506 ankyrin binding 2/869 19/18639 0.105263157894737 2.25776754890679 0.221220179977742 0.701496167795339 GO:0043395 heparan sulfate proteoglycan binding 2/869 19/18639 0.105263157894737 2.25776754890679 0.221220179977742 0.701496167795339 GO:0046624 sphingolipid transporter activity 2/869 19/18639 0.105263157894737 2.25776754890679 0.221220179977742 0.701496167795339 GO:0140036 ubiquitin-modified protein reader activity 2/869 19/18639 0.105263157894737 2.25776754890679 0.221220179977742 0.701496167795339 GO:0005154 epidermal growth factor receptor binding 3/869 35/18639 0.0857142857142857 1.83846786125267 0.222409225613273 0.701496167795339 GO:0005343 organic acid:sodium symporter activity 3/869 35/18639 0.0857142857142857 1.83846786125267 0.222409225613273 0.701496167795339 GO:0061631 ubiquitin conjugating enzyme activity 3/869 35/18639 0.0857142857142857 1.83846786125267 0.222409225613273 0.701496167795339 GO:0004197 cysteine-type endopeptidase activity 6/869 88/18639 0.0681818181818182 1.46241761690553 0.227269710658577 0.710399381831582 GO:0016782 transferase activity, transferring sulphur-containing groups 5/869 70/18639 0.0714285714285714 1.53205655104389 0.227273365451866 0.710399381831582 GO:0097110 scaffold protein binding 5/869 70/18639 0.0714285714285714 1.53205655104389 0.227273365451866 0.710399381831582 GO:0005544 calcium-dependent phospholipid binding 4/869 53/18639 0.0754716981132075 1.61877673317845 0.233302882999727 0.720283746035376 GO:0016860 intramolecular oxidoreductase activity 4/869 53/18639 0.0754716981132075 1.61877673317845 0.233302882999727 0.720283746035376 GO:0051018 protein kinase A binding 4/869 53/18639 0.0754716981132075 1.61877673317845 0.233302882999727 0.720283746035376 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/869 36/18639 0.0833333333333333 1.78739930955121 0.23489234834055 0.720283746035376 GO:0005484 SNAP receptor activity 3/869 36/18639 0.0833333333333333 1.78739930955121 0.23489234834055 0.720283746035376 GO:0044390 ubiquitin-like protein conjugating enzyme binding 3/869 36/18639 0.0833333333333333 1.78739930955121 0.23489234834055 0.720283746035376 GO:0000339 RNA cap binding 2/869 20/18639 0.1 2.14487917146145 0.238714728092184 0.720283746035376 GO:0001614 purinergic nucleotide receptor activity 2/869 20/18639 0.1 2.14487917146145 0.238714728092184 0.720283746035376 GO:0015095 magnesium ion transmembrane transporter activity 2/869 20/18639 0.1 2.14487917146145 0.238714728092184 0.720283746035376 GO:0016502 nucleotide receptor activity 2/869 20/18639 0.1 2.14487917146145 0.238714728092184 0.720283746035376 GO:0042288 MHC class I protein binding 2/869 20/18639 0.1 2.14487917146145 0.238714728092184 0.720283746035376 GO:0043024 ribosomal small subunit binding 2/869 20/18639 0.1 2.14487917146145 0.238714728092184 0.720283746035376 GO:0003925 G protein activity 4/869 54/18639 0.0740740740740741 1.58879938626774 0.243482544140679 0.728354659263234 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 4/869 54/18639 0.0740740740740741 1.58879938626774 0.243482544140679 0.728354659263234 GO:0017069 snRNA binding 4/869 54/18639 0.0740740740740741 1.58879938626774 0.243482544140679 0.728354659263234 GO:1901981 phosphatidylinositol phosphate binding 11/869 185/18639 0.0594594594594595 1.27533356140951 0.246031592267161 0.733877092362618 GO:0072341 modified amino acid binding 6/869 91/18639 0.0659340659340659 1.41420604711744 0.250476737598898 0.742816298759229 GO:0035091 phosphatidylinositol binding 16/869 284/18639 0.0563380281690141 1.20838263180927 0.252885141568692 0.742816298759229 GO:0008374 O-acyltransferase activity 4/869 55/18639 0.0727272727272727 1.55991212469924 0.253759347753705 0.742816298759229 GO:0001846 opsonin binding 2/869 21/18639 0.0952380952380952 2.04274206805852 0.256272526613083 0.742816298759229 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 2/869 21/18639 0.0952380952380952 2.04274206805852 0.256272526613083 0.742816298759229 GO:0009975 cyclase activity 2/869 21/18639 0.0952380952380952 2.04274206805852 0.256272526613083 0.742816298759229 GO:0010314 phosphatidylinositol-5-phosphate binding 2/869 21/18639 0.0952380952380952 2.04274206805852 0.256272526613083 0.742816298759229 GO:0035613 RNA stem-loop binding 2/869 21/18639 0.0952380952380952 2.04274206805852 0.256272526613083 0.742816298759229 GO:0061891 calcium ion sensor activity 2/869 21/18639 0.0952380952380952 2.04274206805852 0.256272526613083 0.742816298759229 GO:0070182 DNA polymerase binding 2/869 21/18639 0.0952380952380952 2.04274206805852 0.256272526613083 0.742816298759229 GO:0008234 cysteine-type peptidase activity 11/869 187/18639 0.0588235294117647 1.26169363027144 0.256855061160998 0.742816298759229 GO:0004175 endopeptidase activity 22/869 405/18639 0.054320987654321 1.16511954992968 0.259492703740879 0.747959997127338 GO:0042887 amide transmembrane transporter activity 3/869 38/18639 0.0789473684210526 1.69332566168009 0.260196526995658 0.747959997127338 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8/869 130/18639 0.0615384615384615 1.31992564397628 0.260782987504168 0.747959997127338 GO:0048029 monosaccharide binding 5/869 74/18639 0.0675675675675676 1.4492426834199 0.262407122911125 0.75055626388826 GO:0030170 pyridoxal phosphate binding 4/869 56/18639 0.0714285714285714 1.53205655104389 0.264123109361144 0.751407016367955 GO:0019207 kinase regulator activity 16/869 287/18639 0.0557491289198606 1.19575145447328 0.266117822730212 0.751407016367955 GO:0019842 vitamin binding 9/869 150/18639 0.06 1.28692750287687 0.266291181586906 0.751407016367955 GO:0051213 dioxygenase activity 6/869 93/18639 0.0645161290322581 1.3837930138461 0.26630325292734 0.751407016367955 GO:0051219 phosphoprotein binding 6/869 93/18639 0.0645161290322581 1.3837930138461 0.26630325292734 0.751407016367955 GO:0000217 DNA secondary structure binding 3/869 39/18639 0.0769230769230769 1.64990705497035 0.272980025343531 0.764385566644774 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/869 39/18639 0.0769230769230769 1.64990705497035 0.272980025343531 0.764385566644774 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 2/869 22/18639 0.0909090909090909 1.94989015587405 0.273849704914818 0.764385566644774 GO:0140784 metal ion sensor activity 2/869 22/18639 0.0909090909090909 1.94989015587405 0.273849704914818 0.764385566644774 GO:0070279 vitamin B6 binding 4/869 57/18639 0.0701754385964912 1.50517836593786 0.274563781122405 0.764385566644774 GO:0000287 magnesium ion binding 13/869 230/18639 0.0565217391304348 1.21232300995647 0.277241354314763 0.769787164639928 GO:0015036 disulfide oxidoreductase activity 3/869 40/18639 0.075 1.60865937859609 0.285827162554147 0.787344479436753 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/869 40/18639 0.075 1.60865937859609 0.285827162554147 0.787344479436753 GO:0071949 FAD binding 3/869 40/18639 0.075 1.60865937859609 0.285827162554147 0.787344479436753 GO:0004896 cytokine receptor activity 6/869 96/18639 0.0625 1.34054948216341 0.290487329211926 0.790203157417038 GO:0005283 amino acid:sodium symporter activity 2/869 23/18639 0.0869565217391304 1.86511232300996 0.291406336786935 0.790203157417038 GO:0016849 phosphorus-oxygen lyase activity 2/869 23/18639 0.0869565217391304 1.86511232300996 0.291406336786935 0.790203157417038 GO:0042171 lysophosphatidic acid acyltransferase activity 2/869 23/18639 0.0869565217391304 1.86511232300996 0.291406336786935 0.790203157417038 GO:0043274 phospholipase binding 2/869 23/18639 0.0869565217391304 1.86511232300996 0.291406336786935 0.790203157417038 GO:0071617 lysophospholipid acyltransferase activity 2/869 23/18639 0.0869565217391304 1.86511232300996 0.291406336786935 0.790203157417038 GO:0001786 phosphatidylserine binding 4/869 59/18639 0.0677966101694915 1.45415537048234 0.295636463207157 0.791396070739157 GO:0004879 nuclear receptor activity 4/869 59/18639 0.0677966101694915 1.45415537048234 0.295636463207157 0.791396070739157 GO:0036002 pre-mRNA binding 4/869 59/18639 0.0677966101694915 1.45415537048234 0.295636463207157 0.791396070739157 GO:0045309 protein phosphorylated amino acid binding 4/869 59/18639 0.0677966101694915 1.45415537048234 0.295636463207157 0.791396070739157 GO:0070063 RNA polymerase binding 4/869 59/18639 0.0677966101694915 1.45415537048234 0.295636463207157 0.791396070739157 GO:0015294 solute:monoatomic cation symporter activity 7/869 116/18639 0.0603448275862069 1.29432363795088 0.297034194784349 0.793104090421639 GO:0140375 immune receptor activity 9/869 156/18639 0.0576923076923077 1.23743029122776 0.304308636084306 0.795522168898762 GO:1990782 protein tyrosine kinase binding 7/869 117/18639 0.0598290598290598 1.28326104275471 0.304494640800711 0.795522168898762 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 4/869 60/18639 0.0666666666666667 1.42991944764097 0.306249229282755 0.795522168898762 GO:0098531 ligand-modulated transcription factor activity 4/869 60/18639 0.0666666666666667 1.42991944764097 0.306249229282755 0.795522168898762 GO:0015370 solute:sodium symporter activity 5/869 79/18639 0.0632911392405063 1.35751846295028 0.307869745981622 0.795522168898762 GO:0033293 monocarboxylic acid binding 5/869 79/18639 0.0632911392405063 1.35751846295028 0.307869745981622 0.795522168898762 GO:0005315 phosphate transmembrane transporter activity 2/869 24/18639 0.0833333333333333 1.78739930955121 0.308906168699021 0.795522168898762 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 2/869 24/18639 0.0833333333333333 1.78739930955121 0.308906168699021 0.795522168898762 GO:0042625 ATPase-coupled ion transmembrane transporter activity 2/869 24/18639 0.0833333333333333 1.78739930955121 0.308906168699021 0.795522168898762 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 2/869 24/18639 0.0833333333333333 1.78739930955121 0.308906168699021 0.795522168898762 GO:0046961 proton-transporting ATPase activity, rotational mechanism 2/869 24/18639 0.0833333333333333 1.78739930955121 0.308906168699021 0.795522168898762 GO:0050431 transforming growth factor beta binding 2/869 24/18639 0.0833333333333333 1.78739930955121 0.308906168699021 0.795522168898762 GO:0060229 lipase activator activity 2/869 24/18639 0.0833333333333333 1.78739930955121 0.308906168699021 0.795522168898762 GO:0008307 structural constituent of muscle 3/869 42/18639 0.0714285714285714 1.53205655104389 0.311644475020416 0.795522168898762 GO:0016859 cis-trans isomerase activity 3/869 42/18639 0.0714285714285714 1.53205655104389 0.311644475020416 0.795522168898762 GO:0043021 ribonucleoprotein complex binding 10/869 177/18639 0.0564971751412429 1.21179614206862 0.312297434290855 0.795522168898762 GO:0019905 syntaxin binding 4/869 61/18639 0.0655737704918033 1.40647814522062 0.316900447736139 0.795522168898762 GO:0048306 calcium-dependent protein binding 5/869 80/18639 0.0625 1.34054948216341 0.317105542803642 0.795522168898762 GO:0140658 ATP-dependent chromatin remodeler activity 9/869 158/18639 0.0569620253164557 1.22176661665526 0.317260956068018 0.795522168898762 GO:0008375 acetylglucosaminyltransferase activity 3/869 43/18639 0.0697674418604651 1.49642732892659 0.324582433218529 0.795522168898762 GO:0003707 nuclear steroid receptor activity 2/869 25/18639 0.08 1.71590333716916 0.326316364783564 0.795522168898762 GO:0004709 MAP kinase kinase kinase activity 2/869 25/18639 0.08 1.71590333716916 0.326316364783564 0.795522168898762 GO:0005537 D-mannose binding 2/869 25/18639 0.08 1.71590333716916 0.326316364783564 0.795522168898762 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 2/869 25/18639 0.08 1.71590333716916 0.326316364783564 0.795522168898762 GO:0120020 cholesterol transfer activity 2/869 25/18639 0.08 1.71590333716916 0.326316364783564 0.795522168898762 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/869 44/18639 0.0681818181818182 1.46241761690553 0.337519610831678 0.795522168898762 GO:0008238 exopeptidase activity 6/869 102/18639 0.0588235294117647 1.26169363027144 0.340019245401433 0.795522168898762 GO:0005112 Notch binding 2/869 26/18639 0.0769230769230769 1.64990705497035 0.343607267571363 0.795522168898762 GO:0005160 transforming growth factor beta receptor binding 2/869 26/18639 0.0769230769230769 1.64990705497035 0.343607267571363 0.795522168898762 GO:0005227 calcium-activated cation channel activity 2/869 26/18639 0.0769230769230769 1.64990705497035 0.343607267571363 0.795522168898762 GO:0008157 protein phosphatase 1 binding 2/869 26/18639 0.0769230769230769 1.64990705497035 0.343607267571363 0.795522168898762 GO:0008198 ferrous iron binding 2/869 26/18639 0.0769230769230769 1.64990705497035 0.343607267571363 0.795522168898762 GO:0034237 protein kinase A regulatory subunit binding 2/869 26/18639 0.0769230769230769 1.64990705497035 0.343607267571363 0.795522168898762 GO:0070006 metalloaminopeptidase activity 2/869 26/18639 0.0769230769230769 1.64990705497035 0.343607267571363 0.795522168898762 GO:0070412 R-SMAD binding 2/869 26/18639 0.0769230769230769 1.64990705497035 0.343607267571363 0.795522168898762 GO:0120014 phospholipid transfer activity 2/869 26/18639 0.0769230769230769 1.64990705497035 0.343607267571363 0.795522168898762 GO:0030695 GTPase regulator activity 25/869 489/18639 0.0511247443762781 1.0965639935897 0.34584394389285 0.795522168898762 GO:0060589 nucleoside-triphosphatase regulator activity 25/869 490/18639 0.0510204081632653 1.09432610788849 0.349643121590271 0.795522168898762 GO:0140303 intramembrane lipid transporter activity 3/869 45/18639 0.0666666666666667 1.42991944764097 0.350441647943234 0.795522168898762 GO:0005044 scavenger receptor activity 2/869 27/18639 0.0740740740740741 1.58879938626774 0.360752173567557 0.795522168898762 GO:0015252 proton channel activity 2/869 27/18639 0.0740740740740741 1.58879938626774 0.360752173567557 0.795522168898762 GO:0035255 ionotropic glutamate receptor binding 2/869 27/18639 0.0740740740740741 1.58879938626774 0.360752173567557 0.795522168898762 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/869 27/18639 0.0740740740740741 1.58879938626774 0.360752173567557 0.795522168898762 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/869 46/18639 0.0652173913043478 1.39883424225747 0.363334884728938 0.795522168898762 GO:0015103 inorganic anion transmembrane transporter activity 9/869 165/18639 0.0545454545454545 1.16993409352443 0.36336728916373 0.795522168898762 GO:0001784 phosphotyrosine residue binding 3/869 47/18639 0.0638297872340425 1.36907181157114 0.376186357168477 0.795522168898762 GO:0019789 SUMO transferase activity 2/869 28/18639 0.0714285714285714 1.53205655104389 0.377727122807019 0.795522168898762 GO:0051537 2 iron, 2 sulfur cluster binding 2/869 28/18639 0.0714285714285714 1.53205655104389 0.377727122807019 0.795522168898762 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/869 28/18639 0.0714285714285714 1.53205655104389 0.377727122807019 0.795522168898762 GO:0001094 TFIID-class transcription factor complex binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0004935 adrenergic receptor activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0005337 nucleoside transmembrane transporter activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0005381 iron ion transmembrane transporter activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0005522 profilin binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0005528 FK506 binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0008140 cAMP response element binding protein binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0008190 eukaryotic initiation factor 4E binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0008239 dipeptidyl-peptidase activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0015187 glycine transmembrane transporter activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0016783 sulfurtransferase activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0019531 oxalate transmembrane transporter activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0030957 Tat protein binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0031419 cobalamin binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0032052 bile acid binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0032356 oxidized DNA binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0035374 chondroitin sulfate binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0043121 neurotrophin binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0043208 glycosphingolipid binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0043422 protein kinase B binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0045322 unmethylated CpG binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0050815 phosphoserine residue binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0051880 G-quadruplex DNA binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0070739 protein-glutamic acid ligase activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0070740 tubulin-glutamic acid ligase activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0099122 RNA polymerase II C-terminal domain binding 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0140135 mechanosensitive monoatomic cation channel activity 1/869 10/18639 0.1 2.14487917146145 0.379706969178131 0.795522168898762 GO:0005096 GTPase activator activity 14/869 271/18639 0.0516605166051661 1.10805566053359 0.3855417837899 0.795522168898762 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3/869 48/18639 0.0625 1.34054948216341 0.388983790260098 0.795522168898762 GO:0005548 phospholipid transporter activity 4/869 68/18639 0.0588235294117647 1.26169363027144 0.39180095290442 0.795522168898762 GO:0030145 manganese ion binding 4/869 68/18639 0.0588235294117647 1.26169363027144 0.39180095290442 0.795522168898762 GO:0008509 monoatomic anion transmembrane transporter activity 8/869 149/18639 0.0536912751677852 1.15161297796588 0.393074447811485 0.795522168898762 GO:0003785 actin monomer binding 2/869 29/18639 0.0689655172413793 1.479227014801 0.39451070157573 0.795522168898762 GO:0004629 phospholipase C activity 2/869 29/18639 0.0689655172413793 1.479227014801 0.39451070157573 0.795522168898762 GO:0005416 amino acid:monoatomic cation symporter activity 2/869 29/18639 0.0689655172413793 1.479227014801 0.39451070157573 0.795522168898762 GO:0035250 UDP-galactosyltransferase activity 2/869 29/18639 0.0689655172413793 1.479227014801 0.39451070157573 0.795522168898762 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 2/869 29/18639 0.0689655172413793 1.479227014801 0.39451070157573 0.795522168898762 GO:0051861 glycolipid binding 2/869 29/18639 0.0689655172413793 1.479227014801 0.39451070157573 0.795522168898762 GO:0005004 GPI-linked ephrin receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0005008 hepatocyte growth factor receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0005009 insulin receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0005011 macrophage colony-stimulating factor receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0005020 stem cell factor receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0008288 boss receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0016763 pentosyltransferase activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0036332 placental growth factor receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0038062 protein tyrosine kinase collagen receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0060175 brain-derived neurotrophic factor receptor activity 3/869 49/18639 0.0612244897959184 1.31319132946619 0.401715589043465 0.795522168898762 GO:0004222 metalloendopeptidase activity 6/869 110/18639 0.0545454545454545 1.16993409352443 0.407128028585955 0.795522168898762 GO:0000510 H3-H4 histone complex chaperone activity 8/869 151/18639 0.0529801324503311 1.13635982593984 0.407360623784359 0.795522168898762 GO:0140584 chromatin extrusion motor activity 8/869 151/18639 0.0529801324503311 1.13635982593984 0.407360623784359 0.795522168898762 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 8/869 151/18639 0.0529801324503311 1.13635982593984 0.407360623784359 0.795522168898762 GO:0140849 ATP-dependent H2AZ histone chaperone activity 8/869 151/18639 0.0529801324503311 1.13635982593984 0.407360623784359 0.795522168898762 GO:0002162 dystroglycan binding 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0003953 NAD+ nucleosidase activity 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0005114 type II transforming growth factor beta receptor binding 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0005536 D-glucose binding 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0008172 S-methyltransferase activity 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0008503 benzodiazepine receptor activity 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0008526 phosphatidylinositol transfer activity 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0016594 glycine binding 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0032404 mismatch repair complex binding 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0034713 type I transforming growth factor beta receptor binding 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0043522 leucine zipper domain binding 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0048185 activin binding 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0097493 structural molecule activity conferring elasticity 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0140537 transcription regulator activator activity 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0180030 inositol phosphate kinase activity 1/869 11/18639 0.0909090909090909 1.94989015587405 0.408642212282119 0.795522168898762 GO:0001968 fibronectin binding 2/869 30/18639 0.0666666666666667 1.42991944764097 0.411083857530099 0.795522168898762 GO:0022839 monoatomic ion-gated channel activity 2/869 30/18639 0.0666666666666667 1.42991944764097 0.411083857530099 0.795522168898762 GO:0031624 ubiquitin conjugating enzyme binding 2/869 30/18639 0.0666666666666667 1.42991944764097 0.411083857530099 0.795522168898762 GO:0048019 receptor antagonist activity 2/869 30/18639 0.0666666666666667 1.42991944764097 0.411083857530099 0.795522168898762 GO:0005007 fibroblast growth factor receptor activity 3/869 50/18639 0.06 1.28692750287687 0.414370827710081 0.795522168898762 GO:0005017 platelet-derived growth factor receptor activity 3/869 50/18639 0.06 1.28692750287687 0.414370827710081 0.795522168898762 GO:0005019 platelet-derived growth factor beta-receptor activity 3/869 50/18639 0.06 1.28692750287687 0.414370827710081 0.795522168898762 GO:0015616 DNA translocase activity 8/869 152/18639 0.0526315789473684 1.12888377445339 0.414502484018468 0.795522168898762 GO:0140674 ATP-dependent histone chaperone activity 8/869 152/18639 0.0526315789473684 1.12888377445339 0.414502484018468 0.795522168898762 GO:0061775 cohesin loader activity 8/869 153/18639 0.0522875816993464 1.12150544913017 0.421640446437515 0.795522168898762 GO:0005010 insulin-like growth factor receptor activity 3/869 51/18639 0.0588235294117647 1.26169363027144 0.426939237056583 0.795522168898762 GO:0005030 neurotrophin receptor activity 3/869 51/18639 0.0588235294117647 1.26169363027144 0.426939237056583 0.795522168898762 GO:0008327 methyl-CpG binding 2/869 31/18639 0.0645161290322581 1.3837930138461 0.427429726489081 0.795522168898762 GO:0016411 acylglycerol O-acyltransferase activity 2/869 31/18639 0.0645161290322581 1.3837930138461 0.427429726489081 0.795522168898762 GO:0047499 calcium-independent phospholipase A2 activity 2/869 31/18639 0.0645161290322581 1.3837930138461 0.427429726489081 0.795522168898762 GO:0043178 alcohol binding 5/869 92/18639 0.0543478260869565 1.16569520188122 0.428926091211666 0.795522168898762 GO:0030246 carbohydrate binding 14/869 280/18639 0.05 1.07243958573072 0.433058475108814 0.795522168898762 GO:0004386 helicase activity 8/869 155/18639 0.0516129032258065 1.10703441107688 0.435895645548466 0.795522168898762 GO:0000340 RNA 7-methylguanosine cap binding 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0003720 telomerase activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0004032 aldose reductase (NADPH) activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0004859 phospholipase inhibitor activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0005095 GTPase inhibitor activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0005165 neurotrophin receptor binding 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0005436 sodium:phosphate symporter activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0005527 macrolide binding 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0008603 cAMP-dependent protein kinase regulator activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0015132 prostaglandin transmembrane transporter activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0015269 calcium-activated potassium channel activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0015368 calcium:monoatomic cation antiporter activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0016208 AMP binding 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0016801 hydrolase activity, acting on ether bonds 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0016803 ether hydrolase activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0031543 peptidyl-proline dioxygenase activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0034452 dynactin binding 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0070410 co-SMAD binding 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0140900 chloride:bicarbonate antiporter activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:1990247 N6-methyladenosine-containing RNA reader activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:1990459 transferrin receptor binding 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:1990817 poly(A) RNA polymerase activity 1/869 12/18639 0.0833333333333333 1.78739930955121 0.436229173712591 0.795522168898762 GO:0015106 bicarbonate transmembrane transporter activity 2/869 32/18639 0.0625 1.34054948216341 0.443533470214433 0.795522168898762 GO:0042910 xenobiotic transmembrane transporter activity 2/869 32/18639 0.0625 1.34054948216341 0.443533470214433 0.795522168898762 GO:0043425 bHLH transcription factor binding 2/869 32/18639 0.0625 1.34054948216341 0.443533470214433 0.795522168898762 GO:0047498 calcium-dependent phospholipase A2 activity 2/869 32/18639 0.0625 1.34054948216341 0.443533470214433 0.795522168898762 GO:0071813 lipoprotein particle binding 2/869 32/18639 0.0625 1.34054948216341 0.443533470214433 0.795522168898762 GO:0071814 protein-lipid complex binding 2/869 32/18639 0.0625 1.34054948216341 0.443533470214433 0.795522168898762 GO:0120015 sterol transfer activity 2/869 32/18639 0.0625 1.34054948216341 0.443533470214433 0.795522168898762 GO:0140142 nucleocytoplasmic carrier activity 2/869 32/18639 0.0625 1.34054948216341 0.443533470214433 0.795522168898762 GO:0016410 N-acyltransferase activity 5/869 94/18639 0.0531914893617021 1.14089317630928 0.44737143107539 0.795522168898762 GO:0044325 transmembrane transporter binding 7/869 136/18639 0.0514705882352941 1.10398192648751 0.449703732787286 0.795522168898762 GO:0004864 protein phosphatase inhibitor activity 3/869 53/18639 0.0566037735849057 1.21408254988384 0.45177768896476 0.795522168898762 GO:0005003 ephrin receptor activity 3/869 53/18639 0.0566037735849057 1.21408254988384 0.45177768896476 0.795522168898762 GO:0005005 transmembrane-ephrin receptor activity 3/869 53/18639 0.0566037735849057 1.21408254988384 0.45177768896476 0.795522168898762 GO:0038064 collagen receptor activity 3/869 53/18639 0.0566037735849057 1.21408254988384 0.45177768896476 0.795522168898762 GO:0035064 methylated histone binding 4/869 74/18639 0.0540540540540541 1.15939414673592 0.455060008556255 0.795522168898762 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/869 33/18639 0.0606060606060606 1.2999267705827 0.459382124532887 0.795522168898762 GO:0019956 chemokine binding 2/869 33/18639 0.0606060606060606 1.2999267705827 0.459382124532887 0.795522168898762 GO:0140311 protein sequestering activity 2/869 33/18639 0.0606060606060606 1.2999267705827 0.459382124532887 0.795522168898762 GO:0140416 transcription regulator inhibitor activity 2/869 33/18639 0.0606060606060606 1.2999267705827 0.459382124532887 0.795522168898762 GO:0002161 aminoacyl-tRNA editing activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0003964 RNA-directed DNA polymerase activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0004535 poly(A)-specific ribonuclease activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0005338 nucleotide-sugar transmembrane transporter activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0005542 folic acid binding 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0008035 high-density lipoprotein particle binding 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0019104 DNA N-glycosylase activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0035325 Toll-like receptor binding 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0035673 oligopeptide transmembrane transporter activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0039706 co-receptor binding 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0043560 insulin receptor substrate binding 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0045159 myosin II binding 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0051011 microtubule minus-end binding 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0070123 transforming growth factor beta receptor activity, type III 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0071714 icosanoid transmembrane transporter activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0089720 caspase binding 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0140333 glycerophospholipid flippase activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0140666 annealing activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/869 13/18639 0.0769230769230769 1.64990705497035 0.46253060969497 0.795522168898762 GO:0050661 NADP binding 3/869 54/18639 0.0555555555555556 1.19159953970081 0.464030344542647 0.79678894687915 GO:0019003 GDP binding 4/869 75/18639 0.0533333333333333 1.14393555811277 0.465407986011694 0.796968541706468 GO:0016407 acetyltransferase activity 5/869 96/18639 0.0520833333333333 1.11712456846951 0.46566169582466 0.796968541706468 GO:0003689 DNA clamp loader activity 8/869 160/18639 0.05 1.07243958573072 0.471311287974222 0.802586967235157 GO:0015035 protein-disulfide reductase activity 2/869 34/18639 0.0588235294117647 1.26169363027144 0.474964457190224 0.802586967235157 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/869 34/18639 0.0588235294117647 1.26169363027144 0.474964457190224 0.802586967235157 GO:0016831 carboxy-lyase activity 2/869 34/18639 0.0588235294117647 1.26169363027144 0.474964457190224 0.802586967235157 GO:0017022 myosin binding 4/869 76/18639 0.0526315789473684 1.12888377445339 0.475684868967493 0.802586967235157 GO:0140034 methylation-dependent protein binding 4/869 76/18639 0.0526315789473684 1.12888377445339 0.475684868967493 0.802586967235157 GO:0140313 molecular sequestering activity 3/869 55/18639 0.0545454545454545 1.16993409352443 0.476161363588162 0.802586967235157 GO:0004713 protein tyrosine kinase activity 7/869 140/18639 0.05 1.07243958573072 0.480015391133265 0.802586967235157 GO:0042393 histone binding 12/869 247/18639 0.048582995951417 1.0420465610339 0.483893001814719 0.802586967235157 GO:0004065 arylsulfatase activity 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0005161 platelet-derived growth factor receptor binding 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0005313 L-glutamate transmembrane transporter activity 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0008559 ABC-type xenobiotic transporter activity 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0015926 glucosidase activity 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0016530 metallochaperone activity 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0019992 diacylglycerol binding 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0030983 mismatched DNA binding 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0031404 chloride ion binding 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0032036 myosin heavy chain binding 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0042043 neurexin family protein binding 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0061665 SUMO ligase activity 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0070742 C2H2 zinc finger domain binding 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:1901474 azole transmembrane transporter activity 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:1901612 cardiolipin binding 1/869 14/18639 0.0714285714285714 1.53205655104389 0.487606358657445 0.802586967235157 GO:0019212 phosphatase inhibitor activity 3/869 56/18639 0.0535714285714286 1.14904241328292 0.488163528921767 0.802586967235157 GO:0004623 phospholipase A2 activity 2/869 35/18639 0.0571428571428571 1.22564524083511 0.490270834861554 0.803520803132594 GO:0043015 gamma-tubulin binding 2/869 35/18639 0.0571428571428571 1.22564524083511 0.490270834861554 0.803520803132594 GO:0140104 molecular carrier activity 12/869 249/18639 0.0481927710843374 1.03367670913805 0.49520530897732 0.809121317755684 GO:0140713 histone chaperone activity 8/869 164/18639 0.0487804878048781 1.04628252266412 0.499279612414447 0.809121317755684 GO:0005516 calmodulin binding 10/869 207/18639 0.0483091787439614 1.03617351278331 0.500152397600087 0.809121317755684 GO:0003779 actin binding 21/869 443/18639 0.0474040632054176 1.01675987811942 0.50081863491052 0.809121317755684 GO:0140097 catalytic activity, acting on DNA 16/869 336/18639 0.0476190476190476 1.02137103402926 0.501912039374643 0.809121317755684 GO:0051020 GTPase binding 15/869 315/18639 0.0476190476190476 1.02137103402926 0.504182064141172 0.809121317755684 GO:0016409 palmitoyltransferase activity 2/869 36/18639 0.0555555555555556 1.19159953970081 0.505293098774554 0.809121317755684 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/869 36/18639 0.0555555555555556 1.19159953970081 0.505293098774554 0.809121317755684 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/869 36/18639 0.0555555555555556 1.19159953970081 0.505293098774554 0.809121317755684 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/869 36/18639 0.0555555555555556 1.19159953970081 0.505293098774554 0.809121317755684 GO:0004089 carbonate dehydratase activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0008242 omega peptidase activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0015929 hexosaminidase activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0016846 carbon-sulfur lyase activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0017081 chloride channel regulator activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0031005 filamin binding 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0047372 monoacylglycerol lipase activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0050780 dopamine receptor binding 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0120283 protein serine/threonine kinase binding 1/869 15/18639 0.0666666666666667 1.42991944764097 0.511513476742099 0.809121317755684 GO:0140597 protein carrier chaperone 9/869 188/18639 0.0478723404255319 1.02680385867835 0.515984523059475 0.814958913879111 GO:0008094 ATP-dependent activity, acting on DNA 10/869 210/18639 0.0476190476190476 1.02137103402926 0.518596173857587 0.815753718724376 GO:0043394 proteoglycan binding 2/869 37/18639 0.0540540540540541 1.15939414673592 0.52002444843305 0.815753718724376 GO:0015293 symporter activity 7/869 146/18639 0.0479452054794521 1.02836672604316 0.524557131409227 0.815753718724376 GO:0015631 tubulin binding 18/869 385/18639 0.0467532467532468 1.00280065159237 0.529682841584344 0.815753718724376 GO:0046873 metal ion transmembrane transporter activity 21/869 450/18639 0.0466666666666667 1.00094361334868 0.530362389485583 0.815753718724376 GO:0015085 calcium ion transmembrane transporter activity 7/869 147/18639 0.0476190476190476 1.02137103402926 0.531844952385196 0.815753718724376 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0004708 MAP kinase kinase activity 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0005024 transforming growth factor beta receptor activity 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0015562 efflux transmembrane transporter activity 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0017070 U6 snRNA binding 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0022841 potassium ion leak channel activity 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0030275 LRR domain binding 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0043023 ribosomal large subunit binding 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0055102 lipase inhibitor activity 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0070411 I-SMAD binding 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0140328 floppase activity 1/869 16/18639 0.0625 1.34054948216341 0.534306367029423 0.815753718724376 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 2/869 38/18639 0.0526315789473684 1.12888377445339 0.53445933295735 0.815753718724376 GO:0043531 ADP binding 2/869 38/18639 0.0526315789473684 1.12888377445339 0.53445933295735 0.815753718724376 GO:0001540 amyloid-beta binding 4/869 83/18639 0.0481927710843374 1.03367670913805 0.545234795340063 0.81876237868736 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/869 39/18639 0.0512820512820513 1.0999380366469 0.548593349585123 0.81876237868736 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/869 39/18639 0.0512820512820513 1.0999380366469 0.548593349585123 0.81876237868736 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 6/869 128/18639 0.046875 1.00541211162255 0.553383853921764 0.81876237868736 GO:0000149 SNARE binding 5/869 106/18639 0.0471698113207547 1.01173545823653 0.55373602641592 0.81876237868736 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0008484 sulfuric ester hydrolase activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0015278 intracellularly gated calcium channel activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0016805 dipeptidase activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0017110 nucleoside diphosphate phosphatase activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0030169 low-density lipoprotein particle binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0030548 acetylcholine receptor regulator activity 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0031489 myosin V binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0036041 long-chain fatty acid binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0045236 CXCR chemokine receptor binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0046965 nuclear retinoid X receptor binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0051787 misfolded protein binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0070402 NADPH binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0070403 NAD+ binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0070492 oligosaccharide binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:1990226 histone methyltransferase binding 1/869 17/18639 0.0588235294117647 1.26169363027144 0.556036902767566 0.81876237868736 GO:0004177 aminopeptidase activity 2/869 40/18639 0.05 1.07243958573072 0.562423148902543 0.822584350900341 GO:0004532 RNA exonuclease activity 2/869 40/18639 0.05 1.07243958573072 0.562423148902543 0.822584350900341 GO:0030331 nuclear estrogen receptor binding 2/869 40/18639 0.05 1.07243958573072 0.562423148902543 0.822584350900341 GO:0050997 quaternary ammonium group binding 2/869 40/18639 0.05 1.07243958573072 0.562423148902543 0.822584350900341 GO:0016798 hydrolase activity, acting on glycosyl bonds 6/869 130/18639 0.0461538461538462 0.989944232982208 0.56867516483518 0.822584350900341 GO:0016758 hexosyltransferase activity 9/869 197/18639 0.0456852791878173 0.979894037723505 0.572873517013613 0.822584350900341 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/869 41/18639 0.0487804878048781 1.04628252266412 0.575946346399872 0.822584350900341 GO:0008227 G protein-coupled amine receptor activity 2/869 41/18639 0.0487804878048781 1.04628252266412 0.575946346399872 0.822584350900341 GO:0042287 MHC protein binding 2/869 41/18639 0.0487804878048781 1.04628252266412 0.575946346399872 0.822584350900341 GO:0140318 protein transporter activity 2/869 41/18639 0.0487804878048781 1.04628252266412 0.575946346399872 0.822584350900341 GO:0005262 calcium channel activity 6/869 131/18639 0.0458015267175573 0.982387406776237 0.576224765230175 0.822584350900341 GO:0000900 mRNA regulatory element binding translation repressor activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0004706 JUN kinase kinase kinase activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0008409 5'-3' exonuclease activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0015172 acidic amino acid transmembrane transporter activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0016854 racemase and epimerase activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0017128 phospholipid scramblase activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0022851 GABA-gated chloride ion channel activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0099602 neurotransmitter receptor regulator activity 1/869 18/18639 0.0555555555555556 1.19159953970081 0.576754544884147 0.822584350900341 GO:0003924 GTPase activity 15/869 331/18639 0.0453172205438066 0.971999624529358 0.582554745648997 0.829723266654233 GO:0031492 nucleosomal DNA binding 2/869 42/18639 0.0476190476190476 1.02137103402926 0.589161439968844 0.835909715467948 GO:0035198 miRNA binding 2/869 42/18639 0.0476190476190476 1.02137103402926 0.589161439968844 0.835909715467948 GO:0016757 glycosyltransferase activity 12/869 267/18639 0.0449438202247191 0.963990638859079 0.593528824539304 0.835909715467948 GO:0003756 protein disulfide isomerase activity 1/869 19/18639 0.0526315789473684 1.12888377445339 0.596506454045614 0.835909715467948 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/869 19/18639 0.0526315789473684 1.12888377445339 0.596506454045614 0.835909715467948 GO:0004890 GABA-A receptor activity 1/869 19/18639 0.0526315789473684 1.12888377445339 0.596506454045614 0.835909715467948 GO:0015245 fatty acid transmembrane transporter activity 1/869 19/18639 0.0526315789473684 1.12888377445339 0.596506454045614 0.835909715467948 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/869 19/18639 0.0526315789473684 1.12888377445339 0.596506454045614 0.835909715467948 GO:0022840 leak channel activity 1/869 19/18639 0.0526315789473684 1.12888377445339 0.596506454045614 0.835909715467948 GO:0022842 narrow pore channel activity 1/869 19/18639 0.0526315789473684 1.12888377445339 0.596506454045614 0.835909715467948 GO:0050145 nucleoside monophosphate kinase activity 1/869 19/18639 0.0526315789473684 1.12888377445339 0.596506454045614 0.835909715467948 GO:1990380 K48-linked deubiquitinase activity 1/869 19/18639 0.0526315789473684 1.12888377445339 0.596506454045614 0.835909715467948 GO:0003727 single-stranded RNA binding 4/869 89/18639 0.0449438202247191 0.963990638859079 0.600834713075796 0.838598182421298 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 4/869 89/18639 0.0449438202247191 0.963990638859079 0.600834713075796 0.838598182421298 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 4/869 89/18639 0.0449438202247191 0.963990638859079 0.600834713075796 0.838598182421298 GO:0140793 histone H2AXY142 phosphatase activity 4/869 90/18639 0.0444444444444444 0.953279631760644 0.60969397936079 0.84527954185209 GO:0140789 histone phosphatase activity 6/869 136/18639 0.0441176470588235 0.946270222703581 0.612944692706472 0.84527954185209 GO:0030547 signaling receptor inhibitor activity 2/869 44/18639 0.0454545454545455 0.974945077937023 0.614665262607215 0.84527954185209 GO:0043014 alpha-tubulin binding 2/869 44/18639 0.0454545454545455 0.974945077937023 0.614665262607215 0.84527954185209 GO:0001972 retinoic acid binding 1/869 20/18639 0.05 1.07243958573072 0.615337597516847 0.84527954185209 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/869 20/18639 0.05 1.07243958573072 0.615337597516847 0.84527954185209 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/869 20/18639 0.05 1.07243958573072 0.615337597516847 0.84527954185209 GO:0005326 neurotransmitter transmembrane transporter activity 1/869 20/18639 0.05 1.07243958573072 0.615337597516847 0.84527954185209 GO:0016004 phospholipase activator activity 1/869 20/18639 0.05 1.07243958573072 0.615337597516847 0.84527954185209 GO:0016505 peptidase activator activity involved in apoptotic process 1/869 20/18639 0.05 1.07243958573072 0.615337597516847 0.84527954185209 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/869 20/18639 0.05 1.07243958573072 0.615337597516847 0.84527954185209 GO:0031418 L-ascorbic acid binding 1/869 20/18639 0.05 1.07243958573072 0.615337597516847 0.84527954185209 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4/869 91/18639 0.043956043956044 0.942804031411626 0.618431355201323 0.848413054967387 GO:0001221 transcription coregulator binding 5/869 115/18639 0.0434782608695652 0.932556161504978 0.626453124798611 0.855708854551154 GO:0017124 SH3 domain binding 5/869 115/18639 0.0434782608695652 0.932556161504978 0.626453124798611 0.855708854551154 GO:0046915 transition metal ion transmembrane transporter activity 2/869 45/18639 0.0444444444444444 0.953279631760644 0.626954733056703 0.855708854551154 GO:0052689 carboxylic ester hydrolase activity 4/869 92/18639 0.0434782608695652 0.932556161504978 0.627045230837216 0.855708854551154 GO:0008237 metallopeptidase activity 8/869 184/18639 0.0434782608695652 0.932556161504978 0.630317660201676 0.855708854551154 GO:0001664 G protein-coupled receptor binding 13/869 297/18639 0.0437710437710438 0.938836000976392 0.632254840519467 0.855708854551154 GO:0005123 death receptor binding 1/869 21/18639 0.0476190476190476 1.02137103402926 0.633290851062036 0.855708854551154 GO:0009931 calcium-dependent protein serine/threonine kinase activity 1/869 21/18639 0.0476190476190476 1.02137103402926 0.633290851062036 0.855708854551154 GO:0036122 BMP binding 1/869 21/18639 0.0476190476190476 1.02137103402926 0.633290851062036 0.855708854551154 GO:0051428 peptide hormone receptor binding 1/869 21/18639 0.0476190476190476 1.02137103402926 0.633290851062036 0.855708854551154 GO:0072542 protein phosphatase activator activity 1/869 21/18639 0.0476190476190476 1.02137103402926 0.633290851062036 0.855708854551154 GO:0070851 growth factor receptor binding 6/869 139/18639 0.0431654676258993 0.925847124371849 0.634102236219275 0.855708854551154 GO:0005126 cytokine receptor binding 12/869 275/18639 0.0436363636363636 0.935947274819542 0.634404840443097 0.855708854551154 GO:0030291 protein serine/threonine kinase inhibitor activity 2/869 46/18639 0.0434782608695652 0.932556161504978 0.638937453435238 0.860175548935153 GO:0008017 microtubule binding 12/869 276/18639 0.0434782608695652 0.932556161504978 0.639364201124214 0.860175548935153 GO:0051015 actin filament binding 9/869 209/18639 0.0430622009569378 0.923632179098232 0.643742804349259 0.860890180295521 GO:0015081 sodium ion transmembrane transporter activity 7/869 164/18639 0.0426829268292683 0.915497207331107 0.64771120666612 0.860890180295521 GO:0008970 phospholipase A1 activity 1/869 22/18639 0.0454545454545455 0.974945077937023 0.650407096116665 0.860890180295521 GO:0015377 chloride:monoatomic cation symporter activity 1/869 22/18639 0.0454545454545455 0.974945077937023 0.650407096116665 0.860890180295521 GO:0016881 acid-amino acid ligase activity 1/869 22/18639 0.0454545454545455 0.974945077937023 0.650407096116665 0.860890180295521 GO:0031683 G-protein beta/gamma-subunit complex binding 1/869 22/18639 0.0454545454545455 0.974945077937023 0.650407096116665 0.860890180295521 GO:0033691 sialic acid binding 1/869 22/18639 0.0454545454545455 0.974945077937023 0.650407096116665 0.860890180295521 GO:0034062 5'-3' RNA polymerase activity 1/869 22/18639 0.0454545454545455 0.974945077937023 0.650407096116665 0.860890180295521 GO:0097747 RNA polymerase activity 1/869 22/18639 0.0454545454545455 0.974945077937023 0.650407096116665 0.860890180295521 GO:0005504 fatty acid binding 2/869 47/18639 0.0425531914893617 0.912714541047426 0.650615279935983 0.860890180295521 GO:0061749 forked DNA-dependent helicase activity 2/869 47/18639 0.0425531914893617 0.912714541047426 0.650615279935983 0.860890180295521 GO:0140359 ABC-type transporter activity 2/869 47/18639 0.0425531914893617 0.912714541047426 0.650615279935983 0.860890180295521 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/869 47/18639 0.0425531914893617 0.912714541047426 0.650615279935983 0.860890180295521 GO:0009378 four-way junction helicase activity 2/869 48/18639 0.0416666666666667 0.893699654775604 0.661990562095804 0.871165489609046 GO:0036121 double-stranded DNA helicase activity 2/869 48/18639 0.0416666666666667 0.893699654775604 0.661990562095804 0.871165489609046 GO:0038187 pattern recognition receptor activity 2/869 48/18639 0.0416666666666667 0.893699654775604 0.661990562095804 0.871165489609046 GO:0043138 3'-5' DNA helicase activity 2/869 48/18639 0.0416666666666667 0.893699654775604 0.661990562095804 0.871165489609046 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 1/869 23/18639 0.0434782608695652 0.932556161504978 0.666725312449835 0.871165489609046 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/869 23/18639 0.0434782608695652 0.932556161504978 0.666725312449835 0.871165489609046 GO:0016917 GABA receptor activity 1/869 23/18639 0.0434782608695652 0.932556161504978 0.666725312449835 0.871165489609046 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 1/869 23/18639 0.0434782608695652 0.932556161504978 0.666725312449835 0.871165489609046 GO:0140103 catalytic activity, acting on a glycoprotein 1/869 23/18639 0.0434782608695652 0.932556161504978 0.666725312449835 0.871165489609046 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 1/869 23/18639 0.0434782608695652 0.932556161504978 0.666725312449835 0.871165489609046 GO:0003697 single-stranded DNA binding 5/869 121/18639 0.0413223140495868 0.886313707215475 0.670746871378925 0.871852024299999 GO:0015108 chloride transmembrane transporter activity 5/869 121/18639 0.0413223140495868 0.886313707215475 0.670746871378925 0.871852024299999 GO:0001222 transcription corepressor binding 2/869 49/18639 0.0408163265306122 0.875460886310796 0.673066092863988 0.871852024299999 GO:0035254 glutamate receptor binding 2/869 49/18639 0.0408163265306122 0.875460886310796 0.673066092863988 0.871852024299999 GO:0031267 small GTPase binding 12/869 283/18639 0.0424028268551237 0.90948940132641 0.673067734896981 0.871852024299999 GO:0004725 protein tyrosine phosphatase activity 4/869 98/18639 0.0408163265306122 0.875460886310796 0.676067627059812 0.871852024299999 GO:0003678 DNA helicase activity 3/869 74/18639 0.0405405405405405 0.869545610051939 0.676896268902922 0.871852024299999 GO:0003684 damaged DNA binding 3/869 74/18639 0.0405405405405405 0.869545610051939 0.676896268902922 0.871852024299999 GO:0031491 nucleosome binding 3/869 74/18639 0.0405405405405405 0.869545610051939 0.676896268902922 0.871852024299999 GO:0001091 RNA polymerase II general transcription initiation factor binding 1/869 24/18639 0.0416666666666667 0.893699654775604 0.682282666525957 0.871852024299999 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 1/869 24/18639 0.0416666666666667 0.893699654775604 0.682282666525957 0.871852024299999 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 1/869 24/18639 0.0416666666666667 0.893699654775604 0.682282666525957 0.871852024299999 GO:0005540 hyaluronic acid binding 1/869 24/18639 0.0416666666666667 0.893699654775604 0.682282666525957 0.871852024299999 GO:0015149 hexose transmembrane transporter activity 1/869 24/18639 0.0416666666666667 0.893699654775604 0.682282666525957 0.871852024299999 GO:0015295 solute:proton symporter activity 1/869 24/18639 0.0416666666666667 0.893699654775604 0.682282666525957 0.871852024299999 GO:0050699 WW domain binding 1/869 24/18639 0.0416666666666667 0.893699654775604 0.682282666525957 0.871852024299999 GO:0055056 D-glucose transmembrane transporter activity 1/869 24/18639 0.0416666666666667 0.893699654775604 0.682282666525957 0.871852024299999 GO:0070300 phosphatidic acid binding 1/869 24/18639 0.0416666666666667 0.893699654775604 0.682282666525957 0.871852024299999 GO:0032813 tumor necrosis factor receptor superfamily binding 2/869 50/18639 0.04 0.85795166858458 0.683845062245401 0.87278025059193 GO:0019001 guanyl nucleotide binding 17/869 400/18639 0.0425 0.911573647871116 0.687636762553133 0.87474475718617 GO:0032561 guanyl ribonucleotide binding 17/869 400/18639 0.0425 0.911573647871116 0.687636762553133 0.87474475718617 GO:0005525 GTP binding 16/869 378/18639 0.0423280423280423 0.907885363581566 0.690327612062911 0.87474475718617 GO:0030544 Hsp70 protein binding 2/869 51/18639 0.0392156862745098 0.841129086847627 0.694331014293924 0.87474475718617 GO:0001848 complement binding 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0008483 transaminase activity 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0015271 outward rectifier potassium channel activity 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0017056 structural constituent of nuclear pore 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0019211 phosphatase activator activity 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0019707 protein-cysteine S-acyltransferase activity 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0042974 nuclear retinoic acid receptor binding 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 1/869 25/18639 0.04 0.85795166858458 0.697114595765223 0.87474475718617 GO:0016755 aminoacyltransferase activity 21/869 496/18639 0.0423387096774194 0.908114165336501 0.707208530856044 0.88211561577858 GO:0004112 cyclic-nucleotide phosphodiesterase activity 1/869 26/18639 0.0384615384615385 0.824953527485173 0.711254888892978 0.88211561577858 GO:0004435 phosphatidylinositol phospholipase C activity 1/869 26/18639 0.0384615384615385 0.824953527485173 0.711254888892978 0.88211561577858 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/869 26/18639 0.0384615384615385 0.824953527485173 0.711254888892978 0.88211561577858 GO:0015145 monosaccharide transmembrane transporter activity 1/869 26/18639 0.0384615384615385 0.824953527485173 0.711254888892978 0.88211561577858 GO:0043548 phosphatidylinositol 3-kinase binding 1/869 26/18639 0.0384615384615385 0.824953527485173 0.711254888892978 0.88211561577858 GO:0051139 metal cation:proton antiporter activity 1/869 26/18639 0.0384615384615385 0.824953527485173 0.711254888892978 0.88211561577858 GO:0052742 phosphatidylinositol kinase activity 1/869 26/18639 0.0384615384615385 0.824953527485173 0.711254888892978 0.88211561577858 GO:0097602 cullin family protein binding 1/869 26/18639 0.0384615384615385 0.824953527485173 0.711254888892978 0.88211561577858 GO:0019783 ubiquitin-like protein peptidase activity 5/869 127/18639 0.0393700787401575 0.84444061868561 0.711438073262035 0.88211561577858 GO:0008146 sulfotransferase activity 2/869 53/18639 0.0377358490566038 0.809388366589226 0.714439576589453 0.883738054454252 GO:0140296 general transcription initiation factor binding 2/869 53/18639 0.0377358490566038 0.809388366589226 0.714439576589453 0.883738054454252 GO:0140463 chromatin-protein adaptor activity 2/869 54/18639 0.037037037037037 0.79439969313387 0.724070700898946 0.893298861997581 GO:0005385 zinc ion transmembrane transporter activity 1/869 27/18639 0.037037037037037 0.79439969313387 0.72473576255934 0.893298861997581 GO:0008320 protein transmembrane transporter activity 1/869 27/18639 0.037037037037037 0.79439969313387 0.72473576255934 0.893298861997581 GO:0016791 phosphatase activity 11/869 273/18639 0.0402930402930403 0.864237028793991 0.73201409070289 0.894357495372483 GO:0030971 receptor tyrosine kinase binding 3/869 81/18639 0.037037037037037 0.79439969313387 0.734810312984556 0.894357495372483 GO:0033192 calmodulin-dependent protein phosphatase activity 3/869 81/18639 0.037037037037037 0.79439969313387 0.734810312984556 0.894357495372483 GO:0140791 histone H2AXS140 phosphatase activity 3/869 81/18639 0.037037037037037 0.79439969313387 0.734810312984556 0.894357495372483 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 3/869 81/18639 0.037037037037037 0.79439969313387 0.734810312984556 0.894357495372483 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 3/869 81/18639 0.037037037037037 0.79439969313387 0.734810312984556 0.894357495372483 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 3/869 81/18639 0.037037037037037 0.79439969313387 0.734810312984556 0.894357495372483 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 3/869 81/18639 0.037037037037037 0.79439969313387 0.734810312984556 0.894357495372483 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 3/869 81/18639 0.037037037037037 0.79439969313387 0.734810312984556 0.894357495372483 GO:1990439 MAP kinase serine/threonine phosphatase activity 3/869 81/18639 0.037037037037037 0.79439969313387 0.734810312984556 0.894357495372483 GO:0046625 sphingolipid binding 1/869 28/18639 0.0357142857142857 0.766028275521946 0.737587934402019 0.894357495372483 GO:0050698 proteoglycan sulfotransferase activity 1/869 28/18639 0.0357142857142857 0.766028275521946 0.737587934402019 0.894357495372483 GO:0051119 sugar transmembrane transporter activity 1/869 28/18639 0.0357142857142857 0.766028275521946 0.737587934402019 0.894357495372483 GO:0051959 dynein light intermediate chain binding 1/869 28/18639 0.0357142857142857 0.766028275521946 0.737587934402019 0.894357495372483 GO:0019888 protein phosphatase regulator activity 4/869 107/18639 0.0373831775700935 0.801823989331383 0.740856912649944 0.895164701504316 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 3/869 82/18639 0.0365853658536585 0.784711891998091 0.742375851860998 0.895164701504316 GO:0033549 MAP kinase phosphatase activity 3/869 82/18639 0.0365853658536585 0.784711891998091 0.742375851860998 0.895164701504316 GO:0170055 lipid transmembrane transporter activity 2/869 56/18639 0.0357142857142857 0.766028275521946 0.742509556946601 0.895164701504316 GO:0005179 hormone activity 5/869 132/18639 0.0378787878787879 0.812454231614186 0.742540834772737 0.895164701504316 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 7/869 181/18639 0.0386740331491713 0.829511281780671 0.744830705714825 0.896621799552779 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 3/869 83/18639 0.036144578313253 0.775257531853536 0.749768641480533 0.896621799552779 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1/869 29/18639 0.0344827586206897 0.7396135074005 0.749840692717243 0.896621799552779 GO:0016417 S-acyltransferase activity 1/869 29/18639 0.0344827586206897 0.7396135074005 0.749840692717243 0.896621799552779 GO:0097472 cyclin-dependent protein kinase activity 1/869 29/18639 0.0344827586206897 0.7396135074005 0.749840692717243 0.896621799552779 GO:0099604 ligand-gated calcium channel activity 1/869 29/18639 0.0344827586206897 0.7396135074005 0.749840692717243 0.896621799552779 GO:0005085 guanyl-nucleotide exchange factor activity 9/869 230/18639 0.0391304347826087 0.839300545354481 0.750328827778298 0.896621799552779 GO:0004620 phospholipase activity 4/869 109/18639 0.036697247706422 0.78711162255466 0.753834003725974 0.896621799552779 GO:0004860 protein kinase inhibitor activity 3/869 84/18639 0.0357142857142857 0.766028275521946 0.756990432052864 0.896621799552779 GO:0017018 myosin phosphatase activity 3/869 84/18639 0.0357142857142857 0.766028275521946 0.756990432052864 0.896621799552779 GO:0017116 single-stranded DNA helicase activity 2/869 58/18639 0.0344827586206897 0.7396135074005 0.759883124015778 0.896621799552779 GO:0061980 regulatory RNA binding 2/869 58/18639 0.0344827586206897 0.7396135074005 0.759883124015778 0.896621799552779 GO:0001965 G-protein alpha-subunit binding 1/869 30/18639 0.0333333333333333 0.714959723820483 0.761521962896111 0.896621799552779 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 1/869 30/18639 0.0333333333333333 0.714959723820483 0.761521962896111 0.896621799552779 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/869 30/18639 0.0333333333333333 0.714959723820483 0.761521962896111 0.896621799552779 GO:0016769 transferase activity, transferring nitrogenous groups 1/869 30/18639 0.0333333333333333 0.714959723820483 0.761521962896111 0.896621799552779 GO:0031210 phosphatidylcholine binding 1/869 30/18639 0.0333333333333333 0.714959723820483 0.761521962896111 0.896621799552779 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/869 30/18639 0.0333333333333333 0.714959723820483 0.761521962896111 0.896621799552779 GO:0070566 adenylyltransferase activity 1/869 30/18639 0.0333333333333333 0.714959723820483 0.761521962896111 0.896621799552779 GO:0098918 structural constituent of synapse 1/869 30/18639 0.0333333333333333 0.714959723820483 0.761521962896111 0.896621799552779 GO:0015079 potassium ion transmembrane transporter activity 6/869 160/18639 0.0375 0.804329689298044 0.761784996363329 0.896621799552779 GO:1902936 phosphatidylinositol bisphosphate binding 4/869 111/18639 0.036036036036036 0.772929431157279 0.766304887888912 0.90092601684237 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 3/869 86/18639 0.0348837209302326 0.748213664463296 0.770928574089894 0.903309450269321 GO:0008083 growth factor activity 6/869 162/18639 0.037037037037037 0.79439969313387 0.772019796302653 0.903309450269321 GO:0043022 ribosome binding 4/869 112/18639 0.0357142857142857 0.766028275521946 0.772352770243795 0.903309450269321 GO:0005164 tumor necrosis factor receptor binding 1/869 31/18639 0.032258064516129 0.691896506923048 0.772658370776345 0.903309450269321 GO:0070273 phosphatidylinositol-4-phosphate binding 1/869 31/18639 0.032258064516129 0.691896506923048 0.772658370776345 0.903309450269321 GO:0001098 basal transcription machinery binding 2/869 60/18639 0.0333333333333333 0.714959723820483 0.776232255408599 0.904449190453769 GO:0001099 basal RNA polymerase II transcription machinery binding 2/869 60/18639 0.0333333333333333 0.714959723820483 0.776232255408599 0.904449190453769 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/869 60/18639 0.0333333333333333 0.714959723820483 0.776232255408599 0.904449190453769 GO:0008081 phosphoric diester hydrolase activity 3/869 87/18639 0.0344827586206897 0.7396135074005 0.777648954450602 0.905089753006052 GO:0022884 macromolecule transmembrane transporter activity 1/869 32/18639 0.03125 0.670274741081703 0.783275303052535 0.908599351540941 GO:0030515 snoRNA binding 1/869 32/18639 0.03125 0.670274741081703 0.783275303052535 0.908599351540941 GO:0051059 NF-kappaB binding 1/869 32/18639 0.03125 0.670274741081703 0.783275303052535 0.908599351540941 GO:0035401 histone H3Y41 kinase activity 4/869 115/18639 0.0347826086956522 0.746044929203983 0.789758782665758 0.913076599228185 GO:0101005 deubiquitinase activity 4/869 115/18639 0.0347826086956522 0.746044929203983 0.789758782665758 0.913076599228185 GO:0140801 histone H2AXY142 kinase activity 4/869 115/18639 0.0347826086956522 0.746044929203983 0.789758782665758 0.913076599228185 GO:0071889 14-3-3 protein binding 1/869 33/18639 0.0303030303030303 0.649963385291349 0.793396964881275 0.916268176256693 GO:0019210 kinase inhibitor activity 3/869 90/18639 0.0333333333333333 0.714959723820483 0.796841305534046 0.918955021581171 GO:0019787 ubiquitin-like protein transferase activity 19/869 479/18639 0.0396659707724426 0.850787145256108 0.797483955510097 0.918955021581171 GO:0019208 phosphatase regulator activity 4/869 117/18639 0.0341880341880342 0.733292024431265 0.800759848780825 0.921297228508795 GO:0042578 phosphoric ester hydrolase activity 14/869 363/18639 0.0385674931129477 0.827226126734444 0.802921542509273 0.921297228508795 GO:0008376 acetylgalactosaminyltransferase activity 1/869 34/18639 0.0294117647058824 0.630846815135721 0.803046434811306 0.921297228508795 GO:0052866 phosphatidylinositol phosphate phosphatase activity 1/869 34/18639 0.0294117647058824 0.630846815135721 0.803046434811306 0.921297228508795 GO:0008236 serine-type peptidase activity 7/869 194/18639 0.0360824742268041 0.773925474238667 0.805185416983877 0.922737184776254 GO:0005261 monoatomic cation channel activity 13/869 341/18639 0.0381231671554252 0.817695871818148 0.808792429383772 0.925747302093812 GO:0000175 3'-5'-RNA exonuclease activity 1/869 35/18639 0.0285714285714286 0.612822620417557 0.81224571716277 0.925747302093812 GO:0010485 histone H4 acetyltransferase activity 1/869 35/18639 0.0285714285714286 0.612822620417557 0.81224571716277 0.925747302093812 GO:0034061 DNA polymerase activity 1/869 35/18639 0.0285714285714286 0.612822620417557 0.81224571716277 0.925747302093812 GO:0140566 histone reader activity 1/869 35/18639 0.0285714285714286 0.612822620417557 0.81224571716277 0.925747302093812 GO:0008235 metalloexopeptidase activity 2/869 66/18639 0.0303030303030303 0.649963385291349 0.819559121467297 0.931077437433033 GO:0000993 RNA polymerase II complex binding 1/869 36/18639 0.0277777777777778 0.595799769850403 0.821015791973861 0.931077437433033 GO:0004033 aldo-keto reductase (NADPH) activity 1/869 36/18639 0.0277777777777778 0.595799769850403 0.821015791973861 0.931077437433033 GO:0055106 ubiquitin-protein transferase regulator activity 1/869 36/18639 0.0277777777777778 0.595799769850403 0.821015791973861 0.931077437433033 GO:0017171 serine hydrolase activity 7/869 198/18639 0.0353535353535354 0.75829061617324 0.821381532448106 0.931077437433033 GO:0008276 protein methyltransferase activity 3/869 95/18639 0.0315789473684211 0.677330264672037 0.825740079949457 0.934542934382541 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/869 122/18639 0.0327868852459016 0.703239072610311 0.826229050225177 0.934542934382541 GO:0030551 cyclic nucleotide binding 1/869 37/18639 0.027027027027027 0.57969707336796 0.829376662627773 0.936474926171808 GO:0061659 ubiquitin-like protein ligase activity 14/869 372/18639 0.0376344086021505 0.807212591410223 0.829732934681761 0.936474926171808 GO:0004721 phosphoprotein phosphatase activity 6/869 175/18639 0.0342857142857143 0.735387144501069 0.830628143328634 0.936474926171808 GO:0004252 serine-type endopeptidase activity 6/869 176/18639 0.0340909090909091 0.731208808452767 0.834589320827865 0.938980329670553 GO:0005267 potassium channel activity 4/869 124/18639 0.032258064516129 0.691896506923048 0.835633623930586 0.938980329670553 GO:0000146 microfilament motor activity 1/869 38/18639 0.0263157894736842 0.564441887226697 0.837347401267514 0.938980329670553 GO:0005501 retinoid binding 1/869 38/18639 0.0263157894736842 0.564441887226697 0.837347401267514 0.938980329670553 GO:0019840 isoprenoid binding 1/869 38/18639 0.0263157894736842 0.564441887226697 0.837347401267514 0.938980329670553 GO:0008080 N-acetyltransferase activity 2/869 69/18639 0.0289855072463768 0.621704107669986 0.838272266912436 0.939008848343973 GO:0046906 tetrapyrrole binding 5/869 152/18639 0.0328947368421053 0.705552359033372 0.842288163322611 0.942194425205391 GO:0004842 ubiquitin-protein transferase activity 17/869 449/18639 0.0378619153674833 0.812092336633511 0.842921066227812 0.942194425205391 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/869 70/18639 0.0285714285714286 0.612822620417557 0.84410869347214 0.942512808540015 GO:0042826 histone deacetylase binding 4/869 127/18639 0.031496062992126 0.675552494948488 0.848939821860517 0.946894416690577 GO:0015144 carbohydrate transmembrane transporter activity 1/869 40/18639 0.025 0.536219792865362 0.8521903726961 0.949505602022122 GO:0031490 chromatin DNA binding 4/869 128/18639 0.03125 0.670274741081703 0.853168105097053 0.949581558338298 GO:0042379 chemokine receptor binding 2/869 72/18639 0.0277777777777778 0.595799769850403 0.855211114441183 0.950841750241315 GO:0001727 lipid kinase activity 1/869 41/18639 0.024390243902439 0.523141261332061 0.859096473353506 0.95110998746666 GO:0004812 aminoacyl-tRNA ligase activity 1/869 41/18639 0.024390243902439 0.523141261332061 0.859096473353506 0.95110998746666 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/869 41/18639 0.024390243902439 0.523141261332061 0.859096473353506 0.95110998746666 GO:0140828 metal cation:monoatomic cation antiporter activity 1/869 41/18639 0.024390243902439 0.523141261332061 0.859096473353506 0.95110998746666 GO:0016298 lipase activity 4/869 130/18639 0.0307692307692308 0.659962821988138 0.861323777104918 0.951337037747806 GO:0004722 protein serine/threonine phosphatase activity 3/869 103/18639 0.029126213592233 0.62472208877518 0.86464700553917 0.951337037747806 GO:0005253 monoatomic anion channel activity 3/869 103/18639 0.029126213592233 0.62472208877518 0.86464700553917 0.951337037747806 GO:0004402 histone acetyltransferase activity 1/869 42/18639 0.0238095238095238 0.510685517014631 0.865680254655571 0.951337037747806 GO:0019894 kinesin binding 1/869 42/18639 0.0238095238095238 0.510685517014631 0.865680254655571 0.951337037747806 GO:0043175 RNA polymerase core enzyme binding 1/869 42/18639 0.0238095238095238 0.510685517014631 0.865680254655571 0.951337037747806 GO:0051879 Hsp90 protein binding 1/869 42/18639 0.0238095238095238 0.510685517014631 0.865680254655571 0.951337037747806 GO:0004712 protein serine/threonine/tyrosine kinase activity 1/869 43/18639 0.0232558139534884 0.498809109642198 0.871956743266869 0.956221470557365 GO:0005245 voltage-gated calcium channel activity 1/869 43/18639 0.0232558139534884 0.498809109642198 0.871956743266869 0.956221470557365 GO:0016790 thiolester hydrolase activity 1/869 44/18639 0.0227272727272727 0.487472538968511 0.877940266072907 0.960764819476012 GO:0019205 nucleobase-containing compound kinase activity 1/869 44/18639 0.0227272727272727 0.487472538968511 0.877940266072907 0.960764819476012 GO:0046982 protein heterodimerization activity 13/869 369/18639 0.035230352303523 0.755648488590755 0.883180115359316 0.9639757993444 GO:0016779 nucleotidyltransferase activity 4/869 136/18639 0.0294117647058824 0.630846815135721 0.883502927046287 0.9639757993444 GO:0008009 chemokine activity 1/869 45/18639 0.0222222222222222 0.476639815880322 0.883644482732366 0.9639757993444 GO:0004843 cysteine-type deubiquitinase activity 3/869 108/18639 0.0277777777777778 0.595799769850403 0.88489066405522 0.964327613020511 GO:0140767 enzyme-substrate adaptor activity 4/869 139/18639 0.0287769784172662 0.617231416247899 0.893387982384154 0.970492942041132 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5/869 167/18639 0.029940119760479 0.642179392653129 0.894174707835337 0.970492942041132 GO:0061733 protein-lysine-acetyltransferase activity 1/869 47/18639 0.0212765957446809 0.456357270523713 0.894266484907633 0.970492942041132 GO:0099095 ligand-gated monoatomic anion channel activity 1/869 47/18639 0.0212765957446809 0.456357270523713 0.894266484907633 0.970492942041132 GO:0005200 structural constituent of cytoskeleton 3/869 112/18639 0.0267857142857143 0.57452120664146 0.899093688024777 0.973831639994334 GO:0140693 molecular condensate scaffold activity 1/869 48/18639 0.0208333333333333 0.446849827387802 0.899208525818523 0.973831639994334 GO:0061630 ubiquitin protein ligase activity 12/869 353/18639 0.0339943342776204 0.72913739539766 0.901817764121938 0.975404674385838 GO:0020037 heme binding 4/869 142/18639 0.028169014084507 0.604191315904634 0.902529612506437 0.975404674385838 GO:0005254 chloride channel activity 2/869 83/18639 0.0240963855421687 0.516838354569024 0.904333284917882 0.976343277615583 GO:0004527 exonuclease activity 2/869 84/18639 0.0238095238095238 0.510685517014631 0.907927013036541 0.978721608613567 GO:0048020 CCR chemokine receptor binding 1/869 50/18639 0.02 0.42897583429229 0.908411148224661 0.978721608613567 GO:0004674 protein serine/threonine kinase activity 15/869 433/18639 0.0346420323325635 0.743029736072096 0.910121242015172 0.97929211916035 GO:0008194 UDP-glycosyltransferase activity 4/869 145/18639 0.0275862068965517 0.5916908059204 0.910971713896824 0.97929211916035 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 17/869 484/18639 0.0351239669421488 0.753366651133154 0.912124289089779 0.97929211916035 GO:0005272 sodium channel activity 1/869 51/18639 0.0196078431372549 0.420564543423814 0.912692750903276 0.97929211916035 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 1/869 52/18639 0.0192307692307692 0.412476763742587 0.916774416465201 0.982661694855923 GO:0005246 calcium channel regulator activity 1/869 53/18639 0.0188679245283019 0.404694183294613 0.920665471078196 0.983802202462268 GO:0016251 RNA polymerase II general transcription initiation factor activity 1/869 53/18639 0.0188679245283019 0.404694183294613 0.920665471078196 0.983802202462268 GO:0034212 protein N-acetyltransferase activity 1/869 53/18639 0.0188679245283019 0.404694183294613 0.920665471078196 0.983802202462268 GO:0001216 DNA-binding transcription activator activity 17/869 491/18639 0.0346232179226069 0.742626189711704 0.922410559683152 0.984659125060542 GO:0004540 RNA nuclease activity 3/869 121/18639 0.0247933884297521 0.531788224329285 0.925437094116887 0.986880823552635 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/869 56/18639 0.0178571428571429 0.383014137760973 0.93128183312959 0.99139982732117 GO:0005216 monoatomic ion channel activity 15/869 448/18639 0.0334821428571429 0.718151508301825 0.93226736342986 0.99139982732117 GO:0005506 iron ion binding 4/869 154/18639 0.025974025974026 0.55711147310687 0.932523592365315 0.99139982732117 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 8/869 268/18639 0.0298507462686567 0.640262439242224 0.935891039334192 0.993967695895114 GO:0008408 3'-5' exonuclease activity 1/869 58/18639 0.0172413793103448 0.36980675370025 0.937558684220678 0.994726896673158 GO:0070888 E-box binding 1/869 59/18639 0.0169491525423729 0.363538842620585 0.940478952420034 0.996812209468543 GO:0030594 neurotransmitter receptor activity 2/869 97/18639 0.0206185567010309 0.442243128136381 0.944475049271264 0.996976125702162 GO:0005249 voltage-gated potassium channel activity 2/869 98/18639 0.0204081632653061 0.437730443155398 0.946623785958615 0.996976125702162 GO:0001217 DNA-binding transcription repressor activity 8/869 278/18639 0.0287769784172662 0.617231416247899 0.950073393552948 0.996976125702162 GO:0022824 transmitter-gated monoatomic ion channel activity 1/869 63/18639 0.0158730158730159 0.340457011343087 0.950857960380928 0.996976125702162 GO:0022835 transmitter-gated channel activity 1/869 63/18639 0.0158730158730159 0.340457011343087 0.950857960380928 0.996976125702162 GO:0140098 catalytic activity, acting on RNA 12/869 387/18639 0.0310077519379845 0.665078812856264 0.951811500843227 0.996976125702162 GO:0099094 ligand-gated monoatomic cation channel activity 3/869 136/18639 0.0220588235294118 0.47313511135179 0.955727944501575 0.996976125702162 GO:0004497 monooxygenase activity 2/869 106/18639 0.0188679245283019 0.404694183294613 0.961175054785281 0.996976125702162 GO:0003777 microtubule motor activity 1/869 68/18639 0.0147058823529412 0.31542340756786 0.961327199166023 0.996976125702162 GO:0140223 general transcription initiation factor activity 1/869 68/18639 0.0147058823529412 0.31542340756786 0.961327199166023 0.996976125702162 GO:0098960 postsynaptic neurotransmitter receptor activity 1/869 69/18639 0.0144927536231884 0.310852053834993 0.963136830522693 0.996976125702162 GO:0005244 voltage-gated monoatomic ion channel activity 4/869 173/18639 0.023121387283237 0.495925819991087 0.963304382183464 0.996976125702162 GO:0022836 gated channel activity 9/869 318/18639 0.0283018867924528 0.60704127494192 0.963535942739604 0.996976125702162 GO:0003730 mRNA 3'-UTR binding 7/869 262/18639 0.0267175572519084 0.573059320619471 0.96361942115417 0.996976125702162 GO:0008168 methyltransferase activity 5/869 204/18639 0.0245098039215686 0.525705679279767 0.963965758508797 0.996976125702162 GO:0005125 cytokine activity 6/869 234/18639 0.0256410256410256 0.549969018323449 0.964461655225907 0.996976125702162 GO:0022843 voltage-gated monoatomic cation channel activity 3/869 143/18639 0.020979020979021 0.449974651355549 0.965509953100479 0.996976125702162 GO:0022832 voltage-gated channel activity 4/869 175/18639 0.0228571428571429 0.490258096334046 0.965642418663143 0.996976125702162 GO:0004521 RNA endonuclease activity 1/869 73/18639 0.0136986301369863 0.29381906458376 0.969568078389726 0.996976125702162 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 1/869 73/18639 0.0136986301369863 0.29381906458376 0.969568078389726 0.996976125702162 GO:0016741 transferase activity, transferring one-carbon groups 5/869 215/18639 0.0232558139534884 0.498809109642198 0.974396720674846 0.996976125702162 GO:0015276 ligand-gated monoatomic ion channel activity 4/869 186/18639 0.021505376344086 0.461264337948699 0.976205853955834 0.996976125702162 GO:0022834 ligand-gated channel activity 4/869 188/18639 0.0212765957446809 0.456357270523713 0.977763786285556 0.996976125702162 GO:0000049 tRNA binding 1/869 80/18639 0.0125 0.268109896432681 0.978244233818068 0.996976125702162 GO:0141003 histone H2AX kinase activity 9/869 354/18639 0.0254237288135593 0.545308263930877 0.985844126019168 0.996976125702162 GO:0140996 histone H3 kinase activity 9/869 357/18639 0.0252100840336134 0.540725841544903 0.986961643048358 0.996976125702162 GO:0035173 histone kinase activity 9/869 360/18639 0.025 0.536219792865362 0.987996802448803 0.996976125702162 GO:0106310 protein serine kinase activity 9/869 361/18639 0.0249307479224377 0.534734419477924 0.988324513048501 0.996976125702162 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 5/869 243/18639 0.0205761316872428 0.44133316285215 0.989657126057587 0.996976125702162 GO:0140101 catalytic activity, acting on a tRNA 2/869 139/18639 0.0143884892086331 0.30861570812395 0.989960030966378 0.996976125702162 GO:0004676 3-phosphoinositide-dependent protein kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0004711 ribosomal protein S6 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0035175 histone H3S10 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0035979 histone H2AXS139 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0044022 histone H3S28 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0044023 histone H4S1 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0044024 histone H2AS1 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0044025 histone H2BS14 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0072354 histone H3T3 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0072371 histone H2AS121 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0072518 Rho-dependent protein serine/threonine kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0140823 histone H2BS36 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0140855 histone H3S57 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0140995 histone H2A kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0140997 histone H4 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0140998 histone H2B kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:1990244 histone H2AT120 kinase activity 5/869 245/18639 0.0204081632653061 0.437730443155398 0.990323171576621 0.996976125702162 GO:0004677 DNA-dependent protein kinase activity 5/869 246/18639 0.0203252032520325 0.435951051110051 0.990640725364995 0.996976125702162 GO:0140857 histone H3T45 kinase activity 5/869 246/18639 0.0203252032520325 0.435951051110051 0.990640725364995 0.996976125702162 GO:0030527 structural constituent of chromatin 1/869 98/18639 0.0102040816326531 0.218865221577699 0.990826879654267 0.996976125702162 GO:0035402 histone H3T11 kinase activity 5/869 247/18639 0.0202429149797571 0.434186067097459 0.990948364519775 0.996976125702162 GO:0035403 histone H3T6 kinase activity 5/869 247/18639 0.0202429149797571 0.434186067097459 0.990948364519775 0.996976125702162 GO:0004679 AMP-activated protein kinase activity 5/869 248/18639 0.0201612903225806 0.432435316826905 0.991246377853298 0.996976125702162 GO:0003774 cytoskeletal motor activity 2/869 153/18639 0.0130718954248366 0.280376362282542 0.994428275258929 0.999213781877114 GO:0004518 nuclease activity 3/869 209/18639 0.0143540669856459 0.307877393032744 0.997175582871564 0.999744558616244 GO:0004519 endonuclease activity 1/869 127/18639 0.0078740157480315 0.168888123737122 0.997722423989276 0.999744558616244 GO:0001653 peptide receptor activity 1/869 128/18639 0.0078125 0.167568685270426 0.997829339155294 0.999744558616244 GO:0045182 translation regulator activity 4/869 356/18639 0.0112359550561798 0.24099765971477 0.999961423615027 0.999997728916431 GO:0030371 translation repressor activity 2/869 329/18639 0.0060790273556231 0.130387791578204 0.999997728916431 0.999997728916431