category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	33/199	227/9376	6.84940119097691	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/GSTA3/MT-ND3/MGST3/MT-ND4/MT-CO2/COX4I1/SLC26A2/MT-ND1/MT-ATP6/MT-ND2/GSTO1/NDUFA10/SLC25A5/HRAS/NDUFB9/NDUFS8/NDUFA6/UQCR10/MAP2K2/NDUFA1/EGFR/HGF/SLC25A6/NDUFC1/NDUFS7/GSTA4/NDUFB7/AKR1A1	13.1370948202315
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	22/199	138/9376	7.51117908382492	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/MT-CO2/COX4I1/MT-ND1/MT-ATP6/MT-ND2/ATP6V0B/NDUFA10/NDUFB9/NDUFS8/NDUFA6/UQCR10/NDUFA1/NDUFC1/NDUFS7/NDUFB7	11.3467638184437
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	26/199	205/9376	5.9756342689055	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/MT-CO2/COX4I1/MT-ND1/MT-ATP6/MT-ND2/PRKCZ/NDUFA10/SLC25A5/NDUFB9/NDUFS8/NDUFA6/UQCR10/COL1A2/NDUFA1/COL3A1/SLC25A6/NDUFC1/NDUFS7/NDUFB7	10.6066648120039
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	28/199	275/9376	4.79722247601645	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/HSPA1A/MT-ND3/MT-ND4/MT-CO2/COX4I1/C1QA/MT-ND1/MT-ATP6/MT-ND2/C1QC/NDUFA10/SLC25A5/NDUFB9/NDUFS8/C1QB/NDUFA6/UQCR10/NDUFA1/SLC25A6/NDUFC1/NDUFS7/HSPA1B/NDUFB7	9.41130055591262
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	28/199	308/9376	4.28323435358611	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/AP2S1/MT-CO2/COX4I1/POLR2J3/MT-ND1/MT-ATP6/MT-ND2/TFAM/NDUFA10/SLC25A5/NDUFB9/NDUFS8/NDUFA6/UQCR10/AP2A1/NDUFA1/POLR2L/SLC25A6/NDUFC1/NDUFS7/NDUFB7	8.62746679282228
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	23/199	235/9376	4.61131187854164	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/MT-CO2/COX4I1/COX20/MT-ND1/MT-ATP6/MT-ND2/NDUFA10/HRAS/NDUFB9/NDUFS8/NDUFA6/UQCR10/NDUFA1/NDUFC1/NDUFS7/NDUFB7	8.25588972919689
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	24/199	268/9376	4.21930548263707	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/MT-CO2/COX4I1/MT-ND1/MT-ATP6/MT-ND2/SLC39A1/NDUFA10/SLC25A5/NDUFB9/NDUFS8/NDUFA6/UQCR10/NDUFA1/SLC25A6/NDUFC1/NDUFS7/NDUFB7	7.87371853460367
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	28/199	388/9376	3.40009324975392	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/MME/MT-CO2/COX4I1/MT-ND1/MT-ATP6/MT-ND2/SLC39A1/NDUFA10/SLC25A5/HRAS/NDUFB9/NDUFS8/NDUFA6/UQCR10/MAP2K2/NDUFA1/SLC25A6/BACE2/NDUFC1/NDUFS7/NDUFB7	7.11007622941446
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	16/199	149/9376	5.05939091430306	MT-ND4L/MT-ND5/MT-ND6/MT-ND3/MT-ND4/GABRE/MT-ND1/MT-ND2/NDUFA10/NDUFB9/NDUFS8/NDUFA6/NDUFA1/NDUFC1/NDUFS7/NDUFB7	7.35504882084141
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	26/199	480/9376	2.55209380234506	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/MT-CO2/COX4I1/MT-ND1/MT-ATP6/MT-ND2/NDUFA10/SLC25A5/HRAS/NDUFB9/NDUFS8/NDUFA6/UQCR10/MAP2K2/NDUFA1/TOMM40/SLC25A6/NDUFC1/NDUFS7/NDUFB7	5.14047210601162
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	22/199	368/9376	2.81669215643435	MT-ATP8/MT-ND4L/MT-CYB/MT-ND5/MT-ND6/MT-ND3/MT-ND4/MT-CO2/COX4I1/MT-ND1/MT-ATP6/MT-ND2/NDUFA10/NDUFB9/NDUFS8/NDUFA6/UQCR10/NDUFA1/TOMM40/NDUFC1/NDUFS7/NDUFB7	5.23543620841156
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/199	50/9376	6.59618090452261	SAT1/CKMT1A/ARG2/SMS/ALDH7A1/CKMT1B/CKMT2	5.84239414491922
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	12/199	157/9376	3.60119066670934	MT-CYB/MT-CO2/COX4I1/NDUFA10/NDUFB9/NDUFS8/NDUFA6/UQCR10/NDUFA1/NDUFC1/NDUFS7/NDUFB7	4.83996160372393
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/199	59/9376	5.58998381739205	GSTA3/MGST3/GPX4/SMS/GSTO1/GGCT/GSTA4	5.20787945253273
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	12/199	170/9376	3.32580549807863	PLCG2/GSTA3/MGST3/CCND1/BRD7/GSTO1/HRAS/GADD45G/MAP2K2/EGFR/HGF/GSTA4	4.50634231365363
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/199	103/9376	4.11689515538859	COL14A1/MME/KCNN4/COL6A2/COL1A2/SLC3A2/COL3A1/ATP1B3/COL21A1	4.68373685177522
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/199	82/9376	4.59664174531193	HSPA1A/HLA-DPB1/HLA-DRA/PDIA3/HLA-C/HLA-DRB1/CALR/HSPA1B	4.81686620533465
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	13/199	204/9376	3.00246329687654	PLCG2/TWIST1/CD44/ITGB1/CCND1/ITGAV/HRAS/DCN/COL1A2/MAP2K2/EGFR/HGF/VTN	4.25803704891468
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/199	73/9376	4.51793212638535	CCND1/HRAS/GADD45G/MAP2K2/EGFR/HGF/FGF22	4.44323400563639
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/199	73/9376	4.51793212638535	PLCG2/CCND1/HRAS/GADD45G/MAP2K2/EGFR/HGF	4.44323400563639
NA	NA	hsa04518	Integrin signaling	10/199	154/9376	3.05945310970437	ITGB1/CCND1/ITGB8/COL6A2/ITGAV/CCND2/COL1A2/EGFR/HGF/VTN	3.79456083832438
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/199	155/9376	3.03971470254498	ITGB1/HLA-DPB1/HLA-DRA/ATP6V0B/HLA-C/HLA-DRB1/ITGAV/CALR/VAMP3/DYNC1H1	3.77057926535447
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/199	157/9376	3.00099222225779	BSG/ARG2/C1QA/C1QC/ITGAV/CALR/C1QB/RAB17/MAP2K2/SIRPA	3.72318940284744
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/199	44/9376	5.35404294198264	HSPD1/HLA-DPB1/HLA-DRA/HLA-C/HLA-DRB1	4.26278561652975
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	7/199	89/9376	3.70571960928237	CD44/ITGB1/ITGB8/COL6A2/ITGAV/COL1A2/VTN	3.77660775190718
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	12/199	224/9376	2.5240488155061	CCND1/HLA-DPB1/FDPS/HLA-DRA/HLA-C/SLC25A5/HLA-DRB1/HRAS/CALR/CCND2/MAP2K2/SLC25A6	3.39959116367221
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/199	31/9376	6.07942940508997	ACSS1/GCSH/PGP/GLUL	4.17126645993296
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	11/199	203/9376	2.55306087085675	ITGB1/CCND1/ITGB8/COL6A2/ITGAV/HRAS/CCND2/COL1A2/EGFR/HGF/VTN	3.29414423239369
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	11/199	205/9376	2.52815295992156	PLCG2/CD44/CCND1/HLA-DPB1/HLA-DRA/PDIA3/HLA-C/HLA-DRB1/CALR/CCND2/GADD45G	3.25759598703886
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/199	32/9376	5.8894472361809	ACSS1/ECHS1/LDHB/HADHA	4.07971803801946
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/199	76/9376	3.71965088600899	PLCG2/CCND1/HRAS/GADD45G/MAP2K2/EGFR	3.50542186193645
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/199	54/9376	4.36255350828215	HLA-DPB1/HLA-DRA/HLA-C/CGA/HLA-DRB1	3.64899564593783
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/199	160/9376	2.65025125628141	ITGB1/HLA-DPB1/HLA-DRA/ITGB8/HLA-C/HLA-DRB1/ITGAV/NRCAM/JAM3	3.10027801700573
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/199	37/9376	5.09357598804835	CCND1/HRAS/GADD45G/MAP2K2	3.67379857519475
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/199	59/9376	3.99284558385146	CCND1/HRAS/GADD45G/MAP2K2/EGFR	3.39573724893855
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/199	39/9376	4.83236696302023	HLA-DPB1/HLA-DRA/HLA-C/HLA-DRB1	3.53148627182915
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/199	41/9376	4.59664174531193	CCND1/HRAS/MAP2K2/EGFR	3.3985507416673
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/199	88/9376	3.21242576518958	CD46/C1QA/C1QC/C1QB/VTN/F5	3.07051165875772
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	14/199	333/9376	1.98083510646325	ITGB1/CCND1/PRKCZ/ATP6V0B/ITGB8/HLA-C/COL6A2/ITGAV/HRAS/CCND2/COL1A2/MAP2K2/EGFR/VTN	2.68363633765793
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	9/199	174/9376	2.43701264945417	RRBP1/HSPA1A/TUSC3/HSP90B1/PDIA3/LMAN1/CALR/LMAN2/HSPA1B	2.81744801318127
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/199	43/9376	4.3828444548323	ECHS1/ECI1/ALDH7A1/HADHA	3.27391526263449
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	8/199	150/9376	2.51283082077052	CCND1/ABCB1/HRAS/GADD45G/MAP2K2/EGFR/HGF/FGF22	2.75036972430627
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/199	45/9376	4.18805136795087	HLA-DPB1/HLA-DRA/HLA-C/HLA-DRB1	3.15667072872011
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/199	70/9376	3.3653984206748	CCND1/HLA-DPB1/HLA-DRA/HLA-C/HLA-DRB1	2.92505212006653
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/199	71/9376	3.31799844291882	CCND1/CGA/HRAS/CCND2/MAP2K2	2.88699436416664
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/199	217/9376	2.17122478753213	GSTA3/MGST3/HSP90B1/CCND1/GSTO1/HRAS/MAP2K2/EGFR/GSTA4/FGF22	2.57044255805444
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/199	47/9376	4.00983641612317	ACSS1/LDHB/ALDH7A1/AKR1A1	3.04604338983165
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/199	48/9376	3.92629815745394	ECHS1/ALDH7A1/OXCT1/HADHA	2.99300012092243
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/199	157/9376	2.40079377780623	CCND1/HLA-C/SLC25A5/HRAS/CCND2/GADD45G/MAP2K2/SLC25A6	2.60641720197096
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/199	99/9376	2.85548956905741	C1QA/HLA-DPB1/HLA-DRA/C1QC/HLA-DRB1/C1QB	2.73296548389041
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/199	27/9376	5.23506420993858	ECHS1/OXCT1/HADHA	3.24504790172744
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/199	101/9376	2.79894522115528	PLCG2/CCND1/PRKCZ/HRAS/COL1A2/COL3A1	2.67660002294263
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	14/199	362/9376	1.82214942113884	HSP90B1/ITGB1/CCND1/ITGB8/COL6A2/ITGAV/HRAS/CCND2/COL1A2/MAP2K2/EGFR/HGF/VTN/FGF22	2.34913553434742
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/199	53/9376	3.55589267090168	ATP2B1/AP2S1/AP2A1/ATP1B3	2.74766964494767
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	10/199	232/9376	2.03084387454514	ITGB1/IQGAP2/ITGB8/ITGAV/HRAS/TMSB4X/MAP2K2/EGFR/DIAPH2/FGF22	2.34115727000129
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/199	233/9376	2.02212780641404	FBN2/ITGB1/ITGB8/COL6A2/ITGAV/DCN/COL1A2/COL3A1/DIAPH2/ATP1B3	2.32648691564383
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	5/199	80/9376	2.94472361809045	PLCG2/HRAS/MAP2K2/EGFR/HGF	2.57227048855353
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/199	31/9376	4.55957205381747	ECHS1/ALDH7A1/HADHA	2.92314792384452
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/199	139/9376	2.37272694407288	HSPA1A/HSP90B1/HRAS/MAP2K2/EGFR/FKBP5/HSPA1B	2.40097643191731
Human Diseases	Immune disease	hsa05310	Asthma	3/199	32/9376	4.41708542713568	HLA-DPB1/HLA-DRA/HLA-DRB1	2.85119040683786
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	8/199	173/9376	2.17875504691085	HLA-DPB1/FDPS/HLA-DRA/SLC25A5/PABPN1/HLA-DRB1/MAP2K2/SLC25A6	2.30432491894077
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/199	142/9376	2.32259891004317	GSTA3/MGST3/HSP90B1/PRKCZ/GSTO1/ITGAV/GSTA4	2.33850987459866
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/199	112/9376	2.5240488155061	HSPA1A/ITGB1/HLA-DPB1/HLA-DRA/HLA-DRB1/HSPA1B	2.38929858797742
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/199	116/9376	2.43701264945417	ACSS1/ECHS1/TKT/GCSH/PGP/SDSL	2.29322096176291
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/199	87/9376	2.70779183272685	MT-CYB/MT-CO2/COX4I1/UQCR10/ATP1B3	2.35652411128469
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/199	87/9376	2.70779183272685	CCND1/HRAS/GADD45G/MAP2K2/EGFR	2.35652411128469
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/199	60/9376	3.14103852596315	PLCG2/HSPB1/HRAS/MAP2K2	2.44989334462898
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/199	61/9376	3.08954609111129	SLC34A2/MT2A/ATP2B1/ATP1B3	2.41094472567345
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/199	63/9376	2.99146526282205	ECHS1/ALDH7A1/HADHA/NSD1	2.33539324232997
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/199	122/9376	2.31715956833347	PLCG2/CCND1/ITGAV/HRAS/MAP2K2/ATP1B3	2.15633071662244
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/199	93/9376	2.53309558545415	CGA/HRAS/MAP2K2/EGFR/MAP3K4	2.18790440515041
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/199	65/9376	2.89942017781214	CGA/KCNN4/HRAS/MAP2K2	2.2627750050566
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/199	67/9376	2.81287032175804	ACSS1/LDHB/ALDH7A1/AKR1A1	2.19287782567897
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	11/199	300/9376	1.72757118927973	HSPA1A/HSPB1/DUSP9/HRAS/GADD45G/MAP2K2/EGFR/HGF/MAP3K4/HSPA1B/FGF22	1.88603908114469
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/199	41/9376	3.44748130898394	GCSH/SDSL/ALDH7A1	2.31268222049257
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/199	130/9376	2.1745651333591	PRKCZ/HRAS/COL1A2/MAP2K2/EGFR/COL3A1	1.98579149787911
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/199	42/9376	3.3653984206748	ECHS1/ALDH7A1/HADHA	2.2623347164387
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/199	42/9376	3.3653984206748	SAT1/GPX4/SLC3A2	2.2623347164387
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/199	70/9376	2.69231873653984	GSTA3/MGST3/GSTO1/GSTA4	2.09272165943698
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/199	100/9376	2.35577889447236	MME/CD44/HLA-DPB1/HLA-DRA/HLA-DRB1	2.00710600132675
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	6/199	133/9376	2.12551479200514	CCND1/HRAS/CCND2/GADD45G/MAP2K2/EGFR	1.9250072149076
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/199	71/9376	2.65439875433506	PLCG2/ATP6V0B/EGFR/JAM3	2.06050176368341
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/199	71/9376	2.65439875433506	LDHB/HRAS/MAP2K2/EGFR	2.06050176368341
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/199	20/9376	4.71155778894472	DHCR24/FDFT1	2.44674060123699
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/199	103/9376	2.28716397521589	C1QA/C1QC/CALR/C1QB/CFLAR	1.93421242757346
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/199	73/9376	2.58167550079163	GSTA3/MGST3/GSTO1/GSTA4	1.99769470203517
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/199	106/9376	2.22243291931355	HSP90B1/CCND1/HRAS/MAP2K2/EGFR	1.86380259797674
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/199	75/9376	2.51283082077052	TKT/ARG2/SDSL/GLUL	1.93694809892878
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/199	75/9376	2.51283082077052	GSTA3/MGST3/GSTO1/GSTA4	1.93694809892878
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/199	77/9376	2.44756248776349	CCND1/HRAS/GADD45G/MAP2K2	1.87813311218587
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/199	78/9376	2.41618348151011	C1QA/ITGB1/C1QC/C1QB	1.84941282682623
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/199	78/9376	2.41618348151011	ITGB1/HLA-DPB1/HLA-DRA/HLA-DRB1	1.84941282682623
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/199	143/9376	1.97687739396282	C1QA/HLA-DPB1/HLA-DRA/C1QC/HLA-DRB1/C1QB	1.73339871853582
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/199	23/9376	4.09700677299541	ARG2/GLUL	2.18973931842685
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	9/199	250/9376	1.6961608040201	HSPA1A/AP2S1/PRKCZ/HLA-C/HRAS/AP2A1/EGFR/VPS26A/HSPA1B	1.64286224914594
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/199	214/9376	1.76133001455878	PLCG2/PDIA3/HLA-C/HRAS/CALR/MAP2K2/DDB1/AP1S3	1.65900045524044
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/199	79/9376	2.38559888047834	GSTA3/MGST3/GSTO1/GSTA4	1.82113216294024
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/199	180/9376	1.8322724734785	HLA-DPB1/HLA-DRA/PDIA3/HLA-C/HLA-DRB1/CALR/SRSF2	1.66021415695714
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/199	50/9376	2.82693467336683	HLA-DPB1/HLA-DRA/HLA-DRB1	1.90731368784062
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/199	148/9376	1.91009099551813	CCND1/HRAS/GADD45G/MAP2K2/EGFR/FGF22	1.64332587232976
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	4/199	82/9376	2.29832087265596	GSTA3/MGST3/GSTO1/GSTA4	1.73879924052172
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/199	184/9376	1.79244046318549	PLCG2/ITGB1/PRKCZ/HRAS/PLXNA2/EPHB4/SEMA3F	1.59857257278608
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/199	54/9376	2.61753210496929	LDHB/SMS/SDSL	1.75532302866252
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	4/199	86/9376	2.19142222741615	PLCG2/HRAS/MAP2K2/EGFR	1.63443960471162
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/199	227/9376	1.66046089478228	CCND1/PDIA3/HLA-C/ITGAV/HRAS/CALR/MAP2K2/EGFR	1.48332061975744
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/199	56/9376	2.5240488155061	TUSC3/ALG11/DPM3	1.68440586764729
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/199	56/9376	2.5240488155061	HSPA1A/HSPD1/HSPA1B	1.68440586764729
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/199	28/9376	3.3653984206748	ECHS1/HADHA	1.84580482481258
Organismal Systems	Immune system	hsa04611	Platelet activation	5/199	126/9376	1.86966578926378	PLCG2/ITGB1/PRKCZ/COL1A2/COL3A1	1.44720016365801
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	8/199	238/9376	1.58371690384697	PLCG2/RPS21/C1QA/C1QC/RPL3/C1QB/EGFR/RPL36	1.343157626729
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/199	93/9376	2.02647646836332	ITGB1/CCND1/ITGAV/GADD45G	1.46490043296945
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/199	94/9376	2.00491820806158	S100A9/HSP90B1/MAPK4/S100A8	1.4419017554592
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/199	31/9376	3.03971470254498	ALDH7A1/AKR1A1	1.67502938775607
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/199	31/9376	3.03971470254498	TMEM208/SPCS2	1.67502938775607
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/199	95/9376	1.98381380587146	HLA-DPB1/HLA-DRA/ATP6V0B/HLA-DRB1	1.41918541607988
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/199	62/9376	2.27978602690874	HSPA1A/HRAS/HSPA1B	1.48876757913897
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/199	243/9376	1.5511301362781	HSPA1A/CTNNBL1/SF3A2/DDX39B/PHF5A/SF1/HSPA1B/SRSF2	1.28177671488608
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/199	63/9376	2.24359894711653	GPX4/PLA2G2A/PTGES	1.45836968963698
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/199	63/9376	2.24359894711653	POLR2J3/DDB1/POLR2L	1.45836968963698
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/199	99/9376	1.90365971270494	CCND1/HRAS/MAP2K2/EGFR	1.33100764627824
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/199	34/9376	2.77150458173219	POLR2J3/POLR2L	1.52378473124973
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/199	250/9376	1.50769849246231	MCOLN3/AP2S1/FUCA1/ATP6V0B/AP2A1/VPS26A/PSAP/AP1S3	1.19811210628077
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/199	136/9376	1.73219036358262	HSPA1A/CD46/CCND1/CCND2/HSPA1B	1.26654110134182
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/199	212/9376	1.55570304351948	ITGB1/PRKCZ/HRAS/MAP2K2/EGFR/HGF/FGF22	1.20511911794236
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/199	66/9376	2.14161717679306	HLA-DPB1/HLA-DRA/HLA-DRB1	1.37050123865995
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	8/199	254/9376	1.48395520911645	PLCG2/MCOLN3/ATP2B1/SLC25A5/EGFR/HGF/SLC25A6/FGF22	1.15143334881528
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/199	68/9376	2.07862843629914	CCND1/HRAS/MAP2K2	1.31449804693963
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/199	103/9376	1.82973118017271	PABPN1/DDX39B/PNN/MSI2	1.24683132152302
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/199	103/9376	1.82973118017271	ARG2/HSPB1/COL1A2/COL3A1	1.24683132152302
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/199	36/9376	2.61753210496929	DCXR/AKR1A1	1.43183354276679
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/199	178/9376	1.5881655468353	NOTUM/RNF43/CCND1/CCND2/LGR5/SERPINF1	1.16660730137394
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/199	69/9376	2.04850338649771	PLCG2/HRAS/MAP2K2	1.28721572464244
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/199	70/9376	2.01923905240488	HRAS/MAP2K2/HGF	1.26039119880742
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/199	144/9376	1.63595756560581	C1QA/CCND1/C1QC/ALDH7A1/C1QB	1.13246111038844
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/199	39/9376	2.41618348151011	GCSH/ALDH7A1	1.30499833956475
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/199	110/9376	1.71329374143444	PLCG2/LDHB/MAP2K2/EGFR	1.10810373483866
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/199	75/9376	1.88462311557789	CCND1/CCND2/GADD45G	1.13262437442565
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/199	75/9376	1.88462311557789	HSP90B1/CGA/ATP1B3	1.13262437442565
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/199	77/9376	1.83567186582262	CCND1/GADD45G/EGFR	1.08423851501465
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/199	12/9376	3.92629815745394	CD46	1.4936206349087
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/199	79/9376	1.78919916035876	AP2S1/ATP6V0B/AP2A1	1.0372669855208
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/199	156/9376	1.51011467594382	CCND1/HRAS/MAP2K2/CFLAR/EGFR	0.946076962977481
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/199	44/9376	2.14161717679306	TUSC3/ALG11	1.11768977606839
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/199	44/9376	2.14161717679306	HMGB1/PNKP	1.11768977606839
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/199	157/9376	1.50049611112889	AMOT/CCND1/DLG5/PRKCZ/CCND2	0.931258900656229
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/199	238/9376	1.3857522908661	PLCG2/HRAS/MAP2K2/PLA2G2A/EGFR/HGF/FGF22	0.887632563131695
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/199	45/9376	2.09402568397543	ABCB1/ABCB8	1.08325696624298
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/199	14/9376	3.3653984206748	B3GNT2	1.30420485480159
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	6/199	205/9376	1.37899252359358	CCND1/HLA-C/HRAS/SND1/CCND2/DDB1	0.807906378717181
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/199	125/9376	1.50769849246231	ORMDL1/PRKCZ/HRAS/MAP2K2	0.841450069066192
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/199	86/9376	1.64356667056211	ITGB1/ITGB8/ITGAV	0.882869926743196
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/199	166/9376	1.41914391233275	ATP2B1/SLC25A5/MAP2K2/SLC25A6/ATP1B3	0.802322926294845
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/199	168/9376	1.40224934194783	HMGB1/SLC25A5/CFLAR/GLUL/SLC25A6	0.774692119929416
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/199	89/9376	1.5881655468353	HRAS/MAP2K2/EGFR	0.820953714480438
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/199	89/9376	1.5881655468353	GABRE/GLUL/SLC38A1	0.820953714480438
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/199	170/9376	1.3857522908661	AMOT/ITGB1/CCND1/PRKCZ/JAM3	0.747410680882284
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/199	51/9376	1.84766972115479	PLCG2/ATP6V0B	0.89381810779696
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/199	90/9376	1.57051926298157	HRAS/MAP2K2/EGFR	0.800827610509912
NA	NA	hsa04517	IgSF CAM signaling	8/199	299/9376	1.26061746861397	PLCG2/NRP2/ITGB1/EPB41L3/NRCAM/PLXNA2/MAP2K2/JAM3	0.67441894136157
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/199	52/9376	1.81213761113259	HSD17B1/CGA	0.864752793500492
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/199	91/9376	1.55326080954222	PLCG2/HRAS/MAP2K2	0.780946819535585
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/199	17/9376	2.77150458173219	GLUL	1.07649948777636
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	1/199	17/9376	2.77150458173219	NRP2	1.07649948777636
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/199	133/9376	1.41700986133676	PLCG2/HLA-C/HRAS/MAP2K2	0.713226514180913
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/199	93/9376	1.51985735127249	HLA-DPB1/HLA-DRA/HLA-DRB1	0.741896460788499
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/199	93/9376	1.51985735127249	ATP2B1/KCNN4/ATP1B3	0.741896460788499
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/199	18/9376	2.61753210496929	FUCA1	1.011485012402
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/199	137/9376	1.3756373106408	HRAS/GADD45G/MAP2K2/CFLAR	0.652196303732503
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/199	56/9376	1.6826992103374	CCND1/CCND2	0.754531314240497
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/199	19/9376	2.47976725733933	GCSH	0.950744254964229
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	5/199	181/9376	1.30153530081346	HSPD1/HLA-DPB1/HLA-DRA/ATP6V0B/HLA-DRB1	0.603202862229309
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/199	57/9376	1.65317817155955	ECHS1/HADHA	0.72836026495746
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	4/199	140/9376	1.34615936826992	CCND1/TFAM/HRAS/MAP2K2	0.607659029789901
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/199	99/9376	1.4277447845287	HRAS/MAP2K2/EGFR	0.630028727472151
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/199	99/9376	1.4277447845287	ITGB1/ITGB8/ITGAV	0.630028727472151
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/199	60/9376	1.57051926298157	HRAS/MAP2K2	0.652819334361314
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/199	102/9376	1.3857522908661	ATP2B1/PLA2G2A/ATP1B3	0.576815423564783
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/199	22/9376	2.14161717679306	ALDH7A1	0.789396075092249
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/199	323/9376	1.16694929757145	PLCG2/CD44/CCND1/ABCB1/HRAS/CCND2/MAP2K2/EGFR	0.449625990611286
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/199	104/9376	1.35910320834944	PISD/PCYT2/PLA2G2A	0.542264350476029
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/199	105/9376	1.34615936826992	PLCG2/GADD45G/CFLAR	0.525253867887803
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/199	105/9376	1.34615936826992	ITGB1/ITGB8/ITGAV	0.525253867887803
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/199	149/9376	1.26484772857576	PLCG2/HRAS/MAP2K2/EGFR	0.479867057616978
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/199	23/9376	2.04850338649771	FDPS	0.74134454949774
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/199	23/9376	2.04850338649771	MME	0.74134454949774
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/199	23/9376	2.04850338649771	ATP1B3	0.74134454949774
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/199	195/9376	1.20809174075506	PLCG2/HMGB1/SLC25A5/MAP2K2/SLC25A6	0.432403266189742
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/199	24/9376	1.96314907872697	GLCE	0.695678682984507
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/199	65/9376	1.44971008890607	ALDH7A1/AKR1A1	0.535738622020197
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/199	196/9376	1.20192800738386	PLCG2/CCND1/HLA-C/HRAS/MAP2K2	0.420692786474479
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/199	108/9376	1.30876605248465	DDX39B/RANBP17/PNN	0.475236973211637
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/199	109/9376	1.2967590244802	HLA-DPB1/HLA-DRA/HLA-DRB1	0.458890865398961
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/199	66/9376	1.4277447845287	HSD17B1/COMT	0.513503798772282
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/199	154/9376	1.22378124388175	CCND1/HRAS/MAP2K2/EGFR	0.412318950299912
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/199	67/9376	1.40643516087902	HRAS/MAP2K2	0.491630670528912
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/199	201/9376	1.17202930073252	MLLT1/PROM1/CCND2/ETV4/GADD45G	0.363043969250458
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/199	26/9376	1.81213761113259	PLA2G2A	0.610621796721849
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/199	158/9376	1.19279944023917	CCND1/CDKN1C/CCND2/GADD45G	0.359896622357496
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	3/199	116/9376	1.21850632472708	PLCG2/ITGB1/JAM3	0.348697893739664
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/199	28/9376	1.6826992103374	B3GNT2	0.532734564005087
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/199	120/9376	1.17788944723618	PLCG2/HRAS/MAP2K2	0.288795848733444
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/199	30/9376	1.57051926298157	PLA2G2A	0.460871510192476
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	4/199	168/9376	1.12179947355827	CCND1/HRAS/CCND2/EGFR	0.2345736401214
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/199	122/9376	1.15857978416674	PLCG2/HRAS/MAP2K2	0.25961202260918
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	4/199	169/9376	1.11516160685082	HMGB1/HRAS/MAP2K2/CFLAR	0.222460960111647
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/199	216/9376	1.09063837707054	HSPA1A/HSPD1/HSP90B1/HRAS/HSPA1B	0.198450898680254
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/199	31/9376	1.51985735127249	TKT	0.426910851667624
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/199	78/9376	1.20809174075506	HSPD1/BTG3	0.271749769386257
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/199	33/9376	1.4277447845287	VAMP3	0.362460202696935
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/199	35/9376	1.34615936826992	ENOSF1	0.302117050623632
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/199	36/9376	1.30876605248465	GALNT11	0.27331858790129
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/199	86/9376	1.09571111370808	KCNN4/ATP1B3	0.131300248774774
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/199	37/9376	1.27339399701209	GLUL	0.245358698512559
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/199	37/9376	1.27339399701209	COMT	0.245358698512559
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/199	38/9376	1.23988362866966	PNP	0.218186202619719
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/199	38/9376	1.23988362866966	ATP1B3	0.218186202619719
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/199	138/9376	1.02425169324885	PRKCZ/HRAS/MAP2K2	0.0422624277338153
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/199	90/9376	1.04701284198772	ABCB1/ATP1B3	0.0659910792767025
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/199	41/9376	1.14916043632798	GABRE	0.140945178143094
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/199	193/9376	0.976488660921186	PLCG2/PRKCZ/CXCL9/HRAS	-0.0485987991030548
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/199	144/9376	0.981574539363484	DUSP9/HRAS/MAP2K2	-0.0328105501692875
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/199	43/9376	1.09571111370808	PLA2G2A	0.0926291705564531
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/199	44/9376	1.07080858839653	DYNC1H1	0.0693244959146062
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	2/199	98/9376	0.961542405907086	ATP2B1/ATP1B3	-0.0563546524301932
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/199	47/9376	1.00245910403079	PRKCZ	0.00248868594245778
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/199	101/9376	0.932981740385094	HRAS/MAP2K2	-0.0997145844761383
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/199	155/9376	0.911914410763495	CCND1/MAP2K2/EGFR	-0.162833407994407
NA	NA	hsa03272	Virion - Hepatitis viruses	1/199	48/9376	0.981574539363484	EGFR	-0.0188454501031177
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/199	48/9376	0.981574539363484	ATP1B3	-0.0188454501031177
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/199	49/9376	0.961542405907086	GALNT11	-0.0397439450289328
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/199	158/9376	0.894599580179378	HRAS/MAP2K2/SLC3A2	-0.196749819612792
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/199	105/9376	0.897439578846614	HRAS/TOMM40	-0.155622706882837
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/199	105/9376	0.897439578846614	PLCG2/HRAS	-0.155622706882837
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/199	50/9376	0.942311557788945	HGF	-0.0602265406986751
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/199	51/9376	0.923834860577397	PLA2G2A	-0.0803116816607057
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/199	52/9376	0.906068805566293	LRPAP1	-0.100016624855126
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/199	163/9376	0.8671578752659	HRAS/MAP2K2/DDB1	-0.251936383266907
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/199	109/9376	0.864506016320133	CXCL9/MAP2K2	-0.209520002082887
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/199	109/9376	0.864506016320133	SLC27A2/PRKCZ	-0.209520002082887
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/199	55/9376	0.856646870717222	PSAP	-0.157007022981786
Genetic Information Processing	Translation	hsa03010	Ribosome	4/199	222/9376	0.848929331341392	RPS21/RPL3/MRPS21/RPL36	-0.335438567853908
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/199	115/9376	0.819401354599082	SLC34A2/EGFR	-0.286943424564521
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/199	116/9376	0.812337549818056	GLUL/SLC38A1	-0.299476462268085
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	4/199	226/9376	0.833904033441544	ATP2B1/CGA/MAP2K2/ATP1B3	-0.372189887752748
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/199	59/9376	0.798569116770292	CGA	-0.228547158249799
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/199	122/9376	0.772386522777824	HRAS/MAP2K2	-0.372627542061904
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/199	63/9376	0.747866315705512	GADD45G	-0.29567741574899
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	4/199	248/9376	0.759928675636246	HSP90B1/HRAS/MAP2K2/DYNC1H1	-0.564209148100969
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/199	134/9376	0.703217580439511	MAP2K2/PLA2G2A	-0.509529576936916
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/199	253/9376	0.744910322362802	PLCG2/CD44/ITGB1/EGFR	-0.605684024218639
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/199	73/9376	0.645418875197907	MLLT1	-0.447844601566052
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/199	138/9376	0.682834462165902	ITGB1/MAP2K2	-0.55271132967197
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/199	76/9376	0.619941814334832	SLC27A2	-0.489865916133684
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/199	76/9376	0.619941814334832	ATP1B3	-0.489865916133684
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/199	142/9376	0.663599688583764	PLCG2/SIRPA	-0.594795174932705
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/199	78/9376	0.604045870377529	PLCG2	-0.517081759333727
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/199	78/9376	0.604045870377529	ITGB1	-0.517081759333727
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/199	144/9376	0.654383026242323	SLC25A5/SLC25A6	-0.61544638044815
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/199	83/9376	0.567657564933099	AUTS2	-0.582573535982376
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/199	83/9376	0.567657564933099	SLC27A2	-0.582573535982376
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/199	83/9376	0.567657564933099	POLR2L	-0.582573535982376
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/199	85/9376	0.554300916346438	PNP	-0.60782951475091
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/199	154/9376	0.611890621940873	ATP2B1/ATP1B3	-0.715095012374912
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/199	90/9376	0.523506420993858	HRAS	-0.668845451956507
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/199	91/9376	0.517753603180739	GABRE	-0.680707513225298
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	1/199	93/9376	0.506619117090831	EGFR	-0.704111483573411
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/199	98/9376	0.480771202953543	PLCG2	-0.760862947344184
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/199	98/9376	0.480771202953543	PLCG2	-0.760862947344184
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/199	99/9376	0.475914928176235	PLCG2	-0.771929110140021
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/199	100/9376	0.471155778894472	CXCL9	-0.782905246774008
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/199	107/9376	0.440332503639694	LDHB	-0.857368145084623
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/199	110/9376	0.428323435358611	DCN	-0.888101071972014
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/199	115/9376	0.409700677299541	HRAS	-0.937894682420063
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/199	115/9376	0.409700677299541	HRAS	-0.937894682420063
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/199	117/9376	0.402697246918353	BRD7	-0.95734222794467
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/199	119/9376	0.395929225961741	CFLAR	-0.976535382856686
NA	NA	hsa04082	Neuroactive ligand signaling	2/199	199/9376	0.473523395873842	GABRE/OGFRL1	-1.10539388926049
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/199	122/9376	0.386193261388912	CCND1	-1.00486710673299
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/199	128/9376	0.368090452261307	PNP	-1.05998032023027
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/199	133/9376	0.35425246533419	COMT	-1.10444453690912
NA	NA	hsa04382	Cornified envelope formation	2/199	217/9376	0.434244957506426	S100A9/S100A8	-1.2416411043721
NA	NA	hsa04081	Hormone signaling	2/199	219/9376	0.430279250131938	CGA/ITGAV	-1.25623039786552
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/199	142/9376	0.331799844291882	DDB1	-1.18145618483898
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/199	154/9376	0.305945310970437	AKR1A1	-1.27880199371232
NA	NA	hsa04519	Cadherin signaling	4/199	404/9376	0.466490870192547	GABRE/HRAS/MAP2K2/EGFR	-1.61417165373278
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	1/199	187/9376	0.251954961975654	TXNIP	-1.52151498705607
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/199	191/9376	0.246678418269357	HRAS	-1.54888553337406
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/199	194/9376	0.242863803553852	DYNC1H1	-1.56916293195329
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/199	370/9376	0.382018199103626	GABRE/CGA/OGFRL1	-1.7859627104244
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/199	200/9376	0.235577889447236	ITGB1	-1.60910115387646
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	2/199	298/9376	0.316211932143941	IL1RL1/CXCL9	-1.76642975407434