category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/31	95/9376	22.2859083191851	CCL3/HLA-DRA/CXCL3/CXCL2/HLA-DPB1/IL1B/HLA-DPA1	12.0097353102361
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/31	82/9376	22.1306058221873	HLA-DRA/CD74/IFI30/HLA-DPB1/HLA-DPA1/HLA-B	11.0686428149716
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/31	44/9376	34.3695014662757	HLA-DRA/HLA-DPB1/IL1B/HLA-DPA1/HLA-B	12.7780776776835
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/31	45/9376	33.6057347670251	HLA-DRA/HLA-DPB1/IL1B/HLA-DPA1/HLA-B	12.6273723192681
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/31	54/9376	28.0047789725209	HLA-DRA/HLA-DPB1/CGA/HLA-DPA1/HLA-B	11.461983789619
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	7/31	181/9376	11.6970237034397	HLA-DRA/CD74/CTSD/HLA-DPB1/IL1B/HLA-DPA1/FCGR3A	8.36957125393916
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/31	78/9376	19.3879239040529	HLA-DRA/HLA-DPB1/IL1B/HLA-DPA1/FCGR3A	9.39208599765975
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/31	39/9376	31.0206782464847	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B	10.8199674992111
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/31	155/9376	11.7078043704474	HLA-DRA/OLR1/HLA-DPB1/HLA-DPA1/FCGR3A/HLA-B	7.74201660480028
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/31	105/9376	14.4024577572965	CCL4/CXCL3/CXCL2/IL1B/BCL2A1	7.95412915069436
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/31	180/9376	10.0817204301075	HLA-DRA/CD74/HLA-DPB1/IL1B/HLA-DPA1/HLA-B	7.08568321415743
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/31	66/9376	18.3304007820137	HLA-DRA/HLA-DPB1/IL1B/HLA-DPA1	8.13734193879019
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/31	70/9376	17.2829493087558	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B	7.87548663857898
Human Diseases	Immune disease	hsa05310	Asthma	3/31	32/9376	28.3548387096774	HLA-DRA/HLA-DPB1/HLA-DPA1	8.92728839757481
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/31	99/9376	12.2202671880091	HLA-DRA/HLA-DPB1/HLA-DPA1/FCGR3A	6.46388840710058
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/31	100/9376	12.098064516129	CCL3/CCL4/CXCL3/CXCL2	6.42604418550686
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	4/31	100/9376	12.098064516129	HLA-DRA/HLA-DPB1/IL1B/HLA-DPA1	6.42604418550686
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/31	298/9376	6.08962978999783	CCL3/CCL4/CXCL3/CXCL2/IL1B/IL1RN	5.14252094042598
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/31	109/9376	11.0991417579165	SPP1/CCL3/CCL4/IL1B	6.10808353635751
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/31	109/9376	11.0991417579165	HLA-DRA/HLA-DPB1/IL1B/HLA-DPA1	6.10808353635751
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/31	50/9376	18.1470967741935	HLA-DRA/HLA-DPB1/HLA-DPA1	7.00171981492306
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/31	216/9376	7.00119474313023	CCL3/OLR1/CXCL3/CXCL2/IL1B	5.13917836738156
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/31	56/9376	16.2027649769585	CXCL3/CXCL2/IL1B	6.57181714819672
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	4/31	143/9376	8.46018497631401	HLA-DRA/HLA-DPB1/HLA-DPA1/FCGR3A	5.17753483088839
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	4/31	160/9376	7.56129032258065	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B	4.82119664089461
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/31	173/9376	6.99310087637516	HLA-DRA/HLA-DPB1/IL1B/HLA-DPA1	4.58233420593192
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/31	93/9376	9.75650364203954	HLA-DRA/HLA-DPB1/HLA-DPA1	4.88770362695802
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/31	193/9376	6.26842721042955	CCL3/CCL4/CXCL3/CXCL2	4.25935833917558
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/31	94/9376	9.65271105010295	CXCL3/CXCL2/IL1B	4.85592732191049
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/31	205/9376	5.9014948859166	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B	4.08671140575551
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/31	103/9376	8.80927027873473	CXCL3/CXCL2/IL1B	4.58982121207968
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/31	112/9376	8.10138248847926	HLA-DRA/HLA-DPB1/HLA-DPA1	4.35441157009165
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	4/31	224/9376	5.40092165898617	HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B	3.83960433593911
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	4/31	227/9376	5.32954383970442	CCL3/CCL4/IL1B/HLA-B	3.80316430774764
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/31	119/9376	7.62483057739225	CXCL3/CXCL2/IL1B	4.18880320580395
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/31	133/9376	6.82221683240359	TYROBP/FCGR3A/HLA-B	3.89479453299464
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/31	142/9376	6.38982280781463	IL1B/TYROBP/FCGR3A	3.72735327902764
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/31	144/9376	6.3010752688172	CXCL3/CXCL2/IL1B	3.69210591532593
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/31	52/9376	11.6327543424318	CGA/CYP19A1	4.4281584418498
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/31	52/9376	11.6327543424318	APOC1/APOE	4.4281584418498
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/31	65/9376	9.30620347394541	SPP1/CGA	3.87024014022178
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/31	71/9376	8.51976374375284	CXCL3/CXCL2	3.66312732192765
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/31	187/9376	4.85216491288598	CXCL3/CXCL2/IL1B	3.06456178016252
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/31	76/9376	7.95925297113752	OLR1/FABP5	3.50836506369235
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/31	196/9376	4.62936142198815	CXCL3/CXCL2/HLA-B	2.95742504207299
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/31	83/9376	7.28799067236689	CCL4/IL1B	3.31397935568655
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/31	103/9376	5.87284685248982	CCL3/IL1B	2.86396744490667
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/31	137/9376	4.41535201318578	CTSD/BCL2A1	2.31931696348154
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/31	30/9376	10.0817204301075	IL1B	2.86941060986248
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/31	168/9376	3.60061443932412	FTL/IL1B	1.95895647773305
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/31	37/9376	8.1743679163034	IL1B	2.51832137103678
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/31	42/9376	7.20122887864823	FTL	2.3197722024267
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/31	46/9376	6.5750350631136	FTL	2.18304420215291
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/31	50/9376	6.04903225806452	IL1B	2.06168482472676
Genetic Information Processing	Translation	hsa03010	Ribosome	2/31	222/9376	2.72478930543447	MT-RNR2/RPS16	1.49790377785857
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/31	59/9376	5.12629852378349	CGA	1.83115638166965
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/31	61/9376	4.95822316234796	FTL	1.78628436102701
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	2/31	238/9376	2.54161019246408	IL1B/RPS16	1.38744030626508
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/31	66/9376	4.58260019550342	CYP19A1	1.68217937873913
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/31	250/9376	2.41961290322581	CTSD/LAPTM5	1.3103175035814
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/31	68/9376	4.44781783681214	BCL2A1	1.64341563116476
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	1/31	71/9376	4.25988187187642	CGA	1.58799701134861
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/31	75/9376	4.03268817204301	CGA	1.51869442684817
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/31	78/9376	3.87758478081059	IL1B	1.46979745336954
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/31	88/9376	3.43695014662757	PLAUR	1.32282900762055
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/31	89/9376	3.39833272924973	SPP1	1.30931320205049
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/31	93/9376	3.25216788067985	CGA	1.25711466230297
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/31	93/9376	3.25216788067985	LYZ	1.25711466230297
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/31	98/9376	3.0862409479921	FCGR3A	1.19571355160042
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/31	98/9376	3.0862409479921	NR4A2	1.19571355160042
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/31	99/9376	3.05506679700228	IL1B	1.18390428876385
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/31	101/9376	2.99457042478441	IL1B	1.16072659454244
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/31	105/9376	2.88049155145929	IL1B	1.11603953080574
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	2/31	333/9376	1.81652620362298	SPP1/HLA-B	0.873801548666579
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/31	115/9376	2.63001402524544	NR4A2	1.01295033309187
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/31	125/9376	2.41961290322581	CTSD	0.920253412103345
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/31	136/9376	2.22390891840607	IL1B	0.828055412540229
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	1/31	138/9376	2.1916783543712	IL1B	0.812243879335126
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	2/31	388/9376	1.55902893249085	APOE/IL1B	0.647732142320232
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	1/31	139/9376	2.17591088419587	CTSD	0.80443909875572
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/31	140/9376	2.16036866359447	SPP1	0.796700115083412
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	1/31	142/9376	2.12994093593821	IL1B	0.781415123066824
NA	NA	hsa04518	Integrin signaling	1/31	154/9376	1.96397151235861	SPP1	0.694686458706381
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/31	157/9376	1.92644339428806	HLA-B	0.674223118553708
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/31	157/9376	1.92644339428806	IL1B	0.674223118553708
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/31	169/9376	1.78965451422027	CTSD	0.596620587523351
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/31	195/9376	1.55103391232423	FCGR3A	0.447844733822282
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/31	200/9376	1.51225806451613	IL1B	0.42174887412991
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	1/31	201/9376	1.50473439255336	BCL2A1	0.416614827903901
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	1/31	203/9376	1.4899094231686	SPP1	0.40642924216606
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	1/31	204/9376	1.48260594560405	PLAUR	0.401377072423965
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	1/31	205/9376	1.47537372147915	HLA-B	0.396351573302109
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/31	205/9376	1.47537372147915	CTSD	0.396351573302109
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	1/31	214/9376	1.41332529394031	HLA-B	0.352273973831768
NA	NA	hsa04081	Hormone signaling	1/31	219/9376	1.38105759316541	CGA	0.328634310041289
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/31	226/9376	1.33828147302312	CGA	0.296482263643889
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	1/31	232/9376	1.30367074527253	TMSB4X	0.269746408672244
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	1/31	248/9376	1.21956295525494	IL1B	0.201824518291812
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	1/31	250/9376	1.2098064516129	HLA-B	0.193653541249168
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	1/31	253/9376	1.19546092056611	IL1B	0.181521551653708
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	1/31	275/9376	1.09982404692082	IL1B	0.0967684521542234
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	1/31	300/9376	1.00817204301075	IL1B	0.00828554079073287
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	1/31	362/9376	0.835501693102834	SPP1	-0.183837359274694
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/31	370/9376	0.81743679163034	CGA	-0.206359744942949
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	1/31	480/9376	0.63010752688172	IL1B	-0.4791544852681