ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003735 structural constituent of ribosome 20/149 175/18639 0.114285714285714 14.2964525407478 1.04160329272807e-17 4.61430258678534e-15 GO:0008009 chemokine activity 5/149 45/18639 0.111111111111111 13.8993288590604 2.88185451462807e-05 0.00638330774990118 GO:0005126 cytokine receptor binding 10/149 275/18639 0.0363636363636364 4.54887126296522 7.48918241963443e-05 0.00874849963690938 GO:0005125 cytokine activity 9/149 234/18639 0.0384615384615385 4.81130614352091 0.000113013941885073 0.00874849963690938 GO:0071813 lipoprotein particle binding 4/149 32/18639 0.125 15.636744966443 0.00011848983706875 0.00874849963690938 GO:0071814 protein-lipid complex binding 4/149 32/18639 0.125 15.636744966443 0.00011848983706875 0.00874849963690938 GO:0050840 extracellular matrix binding 5/149 67/18639 0.0746268656716418 9.33537012921967 0.000197827913892459 0.012519680836337 GO:0042379 chemokine receptor binding 5/149 72/18639 0.0694444444444444 8.68708053691275 0.000277578792419572 0.0153709256302338 GO:0005178 integrin binding 7/149 161/18639 0.0434782608695652 5.43886781441494 0.000316541614479058 0.0155808816904692 GO:0005539 glycosaminoglycan binding 8/149 242/18639 0.0330578512396694 4.13533751178657 0.000744164621759834 0.0329664927439607 GO:0043548 phosphatidylinositol 3-kinase binding 3/149 26/18639 0.115384615384615 14.4339184305627 0.00113738407568851 0.0458055586845465 GO:0038024 cargo receptor activity 4/149 65/18639 0.0615384615384615 7.69808982963345 0.00181917877280308 0.0671580163626468 GO:0008201 heparin binding 6/149 172/18639 0.0348837209302326 4.36374278133292 0.00262088733029611 0.0808860155030506 GO:0005131 growth hormone receptor binding 2/149 10/18639 0.2 25.0187919463087 0.00273880413667214 0.0808860155030506 GO:0005381 iron ion transmembrane transporter activity 2/149 10/18639 0.2 25.0187919463087 0.00273880413667214 0.0808860155030506 GO:0035259 nuclear glucocorticoid receptor binding 2/149 12/18639 0.166666666666667 20.8489932885906 0.00397500186444826 0.0956937495701827 GO:0001618 virus receptor activity 4/149 81/18639 0.0493827160493827 6.17747949291573 0.00405175907619563 0.0956937495701827 GO:0140272 exogenous protein binding 4/149 82/18639 0.0487804878048781 6.10214437714847 0.00423350058488885 0.0956937495701827 GO:0042056 chemoattractant activity 3/149 42/18639 0.0714285714285714 8.9352828379674 0.00457485958763092 0.0956937495701827 GO:0008035 high-density lipoprotein particle binding 2/149 13/18639 0.153846153846154 19.2452245740836 0.00467318135376707 0.0956937495701827 GO:0031994 insulin-like growth factor I binding 2/149 13/18639 0.153846153846154 19.2452245740836 0.00467318135376707 0.0956937495701827 GO:0019838 growth factor binding 5/149 136/18639 0.0367647058823529 4.5990426371891 0.00475228553170208 0.0956937495701827 GO:0032036 myosin heavy chain binding 2/149 14/18639 0.142857142857143 17.8705656759348 0.00542357311877562 0.104462734418156 GO:1901681 sulfur compound binding 7/149 275/18639 0.0254545454545455 3.18420988407566 0.00669952136245272 0.12366199848194 GO:0005149 interleukin-1 receptor binding 2/149 16/18639 0.125 15.636744966443 0.00707753197982405 0.125413866682482 GO:0048020 CCR chemokine receptor binding 3/149 50/18639 0.06 7.50563758389262 0.00745649543709268 0.126245414815749 GO:0005021 vascular endothelial growth factor receptor activity 3/149 51/18639 0.0588235294117647 7.35846821950257 0.00787677436497298 0.126245414815749 GO:0030169 low-density lipoprotein particle binding 2/149 17/18639 0.117647058823529 14.7169364390051 0.00797939416442655 0.126245414815749 GO:0008525 phosphatidylcholine transporter activity 2/149 18/18639 0.111111111111111 13.8993288590604 0.00893005858563878 0.130306330172098 GO:0034185 apolipoprotein binding 2/149 18/18639 0.111111111111111 13.8993288590604 0.00893005858563878 0.130306330172098 GO:0005520 insulin-like growth factor binding 2/149 19/18639 0.105263157894737 13.1677852348993 0.00992869813969871 0.130306330172098 GO:0046624 sphingolipid transporter activity 2/149 19/18639 0.105263157894737 13.1677852348993 0.00992869813969871 0.130306330172098 GO:0097001 ceramide binding 2/149 19/18639 0.105263157894737 13.1677852348993 0.00992869813969871 0.130306330172098 GO:0001664 G protein-coupled receptor binding 7/149 297/18639 0.0235690235690236 2.94834248525524 0.0100009373044048 0.130306330172098 GO:0004714 transmembrane receptor protein tyrosine kinase activity 3/149 60/18639 0.05 6.25469798657718 0.0122871115510404 0.155519726203169 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3/149 61/18639 0.0491803278688525 6.15216195401034 0.0128483145792256 0.158095268006608 GO:0061133 endopeptidase activator activity 2/149 22/18639 0.0909090909090909 11.3721781574131 0.0132043451833962 0.158095268006608 GO:0005319 lipid transporter activity 5/149 178/18639 0.0280898876404494 3.51387527335797 0.0142576231164581 0.163419424837663 GO:0005212 structural constituent of eye lens 2/149 23/18639 0.0869565217391304 10.8777356288299 0.014386811667424 0.163419424837663 GO:0048027 mRNA 5'-UTR binding 2/149 24/18639 0.0833333333333333 10.4244966442953 0.0156132649391716 0.172916909201325 GO:0061135 endopeptidase regulator activity 5/149 184/18639 0.0271739130434783 3.39929238400934 0.0162368204546125 0.175436864912033 GO:0120020 cholesterol transfer activity 2/149 25/18639 0.08 10.0075167785235 0.0168829360471916 0.177037557158945 GO:0032934 sterol binding 3/149 68/18639 0.0441176470588235 5.51885116462693 0.017184232410462 0.177037557158945 GO:0008157 protein phosphatase 1 binding 2/149 26/18639 0.0769230769230769 9.62261228704182 0.0181950653781501 0.178908518770378 GO:0050750 low-density lipoprotein particle receptor binding 2/149 26/18639 0.0769230769230769 9.62261228704182 0.0181950653781501 0.178908518770378 GO:0005543 phospholipid binding 9/149 497/18639 0.0181086519114688 2.26528297300582 0.0185774082696104 0.178908518770378 GO:0046625 sphingolipid binding 2/149 28/18639 0.0714285714285714 8.9352828379674 0.0209437063560343 0.193292956577567 GO:0050698 proteoglycan sulfotransferase activity 2/149 28/18639 0.0714285714285714 8.9352828379674 0.0209437063560343 0.193292956577567 GO:0043236 laminin binding 2/149 29/18639 0.0689655172413793 8.62716963665818 0.0223787445850943 0.202322119412179 GO:0017022 myosin binding 3/149 76/18639 0.0394736842105263 4.93791946308725 0.0230227406972845 0.203981482577941 GO:0031210 phosphatidylcholine binding 2/149 30/18639 0.0666666666666667 8.33959731543624 0.0238532940091192 0.20719625972627 GO:0019199 transmembrane receptor protein kinase activity 3/149 78/18639 0.0384615384615385 4.81130614352091 0.0246303993192356 0.209832055738872 GO:0070325 lipoprotein particle receptor binding 2/149 31/18639 0.0645161290322581 8.07057804719636 0.0253666402468322 0.211812409052275 GO:0003779 actin binding 8/149 443/18639 0.018058690744921 2.25903313284955 0.0261758600258504 0.211812409052275 GO:0000049 tRNA binding 3/149 80/18639 0.0375 4.69102348993289 0.0262972516882057 0.211812409052275 GO:0120015 sterol transfer activity 2/149 32/18639 0.0625 7.81837248322148 0.026918077678272 0.212941221633473 GO:0019956 chemokine binding 2/149 33/18639 0.0606060606060606 7.58145210494204 0.0285069093519227 0.217057216732444 GO:0019955 cytokine binding 4/149 144/18639 0.0277777777777778 3.4748322147651 0.0285192491423645 0.217057216732444 GO:0008135 translation factor activity, RNA binding 3/149 83/18639 0.036144578313253 4.5214684240317 0.0289082974880681 0.217057216732444 GO:0180051 translation factor activity 3/149 84/18639 0.0357142857142857 4.4676414189837 0.0298081107228024 0.21883072087687 GO:0051427 hormone receptor binding 2/149 34/18639 0.0588235294117647 7.35846821950257 0.0301324468927518 0.21883072087687 GO:0043394 proteoglycan binding 2/149 37/18639 0.0540540540540541 6.76183566116452 0.0352225377092018 0.24809857047008 GO:0061134 peptidase regulator activity 5/149 226/18639 0.0221238938053097 2.76756548078636 0.0352826409472123 0.24809857047008 GO:0043178 alcohol binding 3/149 92/18639 0.0326086956521739 4.0791508608112 0.0375330044042684 0.259798764860795 GO:0050997 quaternary ammonium group binding 2/149 40/18639 0.05 6.25469798657718 0.0406190042226773 0.276834136471478 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/149 41/18639 0.0487804878048781 6.10214437714847 0.0424829098578412 0.285150440409449 GO:0005201 extracellular matrix structural constituent 4/149 168/18639 0.0238095238095238 2.9784276126558 0.0460174074385748 0.286604078752723 GO:0033218 amide binding 5/149 247/18639 0.0202429149797571 2.53226639132679 0.0484865686446004 0.286604078752723 GO:0004857 enzyme inhibitor activity 7/149 416/18639 0.0168269230769231 2.1049464377904 0.0499231833092088 0.286604078752723 GO:0046915 transition metal ion transmembrane transporter activity 2/149 45/18639 0.0444444444444444 5.55973154362416 0.0502473878340838 0.286604078752723 GO:0030276 clathrin binding 2/149 46/18639 0.0434782608695652 5.43886781441494 0.0522627027091486 0.286604078752723 GO:0061749 forked DNA-dependent helicase activity 2/149 47/18639 0.0425531914893617 5.32314722261888 0.0543065147967688 0.286604078752723 GO:1990518 single-stranded 3'-5' DNA helicase activity 2/149 47/18639 0.0425531914893617 5.32314722261888 0.0543065147967688 0.286604078752723 GO:0019888 protein phosphatase regulator activity 3/149 107/18639 0.0280373831775701 3.50730728219281 0.0544796866002234 0.286604078752723 GO:0005496 steroid binding 3/149 108/18639 0.0277777777777778 3.4748322147651 0.0557200831073605 0.286604078752723 GO:0009378 four-way junction helicase activity 2/149 48/18639 0.0416666666666667 5.21224832214765 0.0563782466261897 0.286604078752723 GO:0036121 double-stranded DNA helicase activity 2/149 48/18639 0.0416666666666667 5.21224832214765 0.0563782466261897 0.286604078752723 GO:0043138 3'-5' DNA helicase activity 2/149 48/18639 0.0416666666666667 5.21224832214765 0.0563782466261897 0.286604078752723 GO:0140693 molecular condensate scaffold activity 2/149 48/18639 0.0416666666666667 5.21224832214765 0.0563782466261897 0.286604078752723 GO:0005004 GPI-linked ephrin receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0005008 hepatocyte growth factor receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0005009 insulin receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0005011 macrophage colony-stimulating factor receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0005018 platelet-derived growth factor alpha-receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0005020 stem cell factor receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0008288 boss receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0036332 placental growth factor receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0038062 protein tyrosine kinase collagen receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0060175 brain-derived neurotrophic factor receptor activity 2/149 49/18639 0.0408163265306122 5.10587590740994 0.0584773280272432 0.286604078752723 GO:0005006 epidermal growth factor receptor activity 2/149 50/18639 0.04 5.00375838926174 0.0606031960518328 0.286604078752723 GO:0005007 fibroblast growth factor receptor activity 2/149 50/18639 0.04 5.00375838926174 0.0606031960518328 0.286604078752723 GO:0005017 platelet-derived growth factor receptor activity 2/149 50/18639 0.04 5.00375838926174 0.0606031960518328 0.286604078752723 GO:0005019 platelet-derived growth factor beta-receptor activity 2/149 50/18639 0.04 5.00375838926174 0.0606031960518328 0.286604078752723 GO:1901981 phosphatidylinositol phosphate binding 4/149 185/18639 0.0216216216216216 2.70473426446581 0.0613375607743991 0.286604078752723 GO:0003743 translation initiation factor activity 2/149 51/18639 0.0392156862745098 4.90564547966838 0.0627552948961944 0.286604078752723 GO:0005010 insulin-like growth factor receptor activity 2/149 51/18639 0.0392156862745098 4.90564547966838 0.0627552948961944 0.286604078752723 GO:0005030 neurotrophin receptor activity 2/149 51/18639 0.0392156862745098 4.90564547966838 0.0627552948961944 0.286604078752723 GO:0004864 protein phosphatase inhibitor activity 2/149 53/18639 0.0377358490566038 4.7205267823224 0.0671359970897704 0.29022767478635 GO:0005003 ephrin receptor activity 2/149 53/18639 0.0377358490566038 4.7205267823224 0.0671359970897704 0.29022767478635 GO:0005005 transmembrane-ephrin receptor activity 2/149 53/18639 0.0377358490566038 4.7205267823224 0.0671359970897704 0.29022767478635 GO:0008146 sulfotransferase activity 2/149 53/18639 0.0377358490566038 4.7205267823224 0.0671359970897704 0.29022767478635 GO:0038064 collagen receptor activity 2/149 53/18639 0.0377358490566038 4.7205267823224 0.0671359970897704 0.29022767478635 GO:0019208 phosphatase regulator activity 3/149 117/18639 0.0256410256410256 3.20753742901394 0.0674795722415215 0.29022767478635 GO:0015485 cholesterol binding 2/149 54/18639 0.037037037037037 4.6331096196868 0.0693635238641718 0.295461933382962 GO:0019212 phosphatase inhibitor activity 2/149 56/18639 0.0357142857142857 4.4676414189837 0.0738902887513483 0.297166899302979 GO:0170055 lipid transmembrane transporter activity 2/149 56/18639 0.0357142857142857 4.4676414189837 0.0738902887513483 0.297166899302979 GO:0004601 peroxidase activity 2/149 57/18639 0.0350877192982456 4.38926174496644 0.0761884911147715 0.297166899302979 GO:0016504 peptidase activator activity 2/149 57/18639 0.0350877192982456 4.38926174496644 0.0761884911147715 0.297166899302979 GO:0031267 small GTPase binding 5/149 283/18639 0.0176678445229682 2.21014063129936 0.0770979504696823 0.297166899302979 GO:0003680 minor groove of adenine-thymine-rich DNA binding 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.297166899302979 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.297166899302979 GO:0015279 store-operated calcium channel activity 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.297166899302979 GO:0043121 neurotrophin binding 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.297166899302979 GO:0043208 glycosphingolipid binding 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.297166899302979 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 1/149 10/18639 0.1 12.5093959731544 0.0771426488032564 0.297166899302979 GO:0017116 single-stranded DNA helicase activity 2/149 58/18639 0.0344827586206897 4.31358481832909 0.078509227342297 0.299552780889449 GO:0004879 nuclear receptor activity 2/149 59/18639 0.0338983050847458 4.24047321123877 0.0808519960768711 0.299552780889449 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 2/149 59/18639 0.0338983050847458 4.24047321123877 0.0808519960768711 0.299552780889449 GO:0042826 histone deacetylase binding 3/149 127/18639 0.0236220472440945 2.95497542672938 0.081751831187103 0.299552780889449 GO:0098531 ligand-modulated transcription factor activity 2/149 60/18639 0.0333333333333333 4.16979865771812 0.0832163024398308 0.299552780889449 GO:0008526 phosphatidylinositol transfer activity 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.299552780889449 GO:0015173 aromatic amino acid transmembrane transporter activity 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.299552780889449 GO:0019215 intermediate filament binding 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.299552780889449 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.299552780889449 GO:1990948 ubiquitin ligase inhibitor activity 1/149 11/18639 0.0909090909090909 11.3721781574131 0.0845239223728693 0.299552780889449 GO:0015026 coreceptor activity 2/149 61/18639 0.0327868852459016 4.10144130267356 0.0856016579605293 0.300964559337417 GO:0051015 actin filament binding 4/149 209/18639 0.0191387559808612 2.3941427699817 0.0869788508862953 0.303398668839597 GO:0005179 hormone activity 3/149 132/18639 0.0227272727272727 2.84304453935326 0.0893375242255546 0.308242593325221 GO:0005095 GTPase inhibitor activity 1/149 12/18639 0.0833333333333333 10.4244966442953 0.0918465515099981 0.308242593325221 GO:0015132 prostaglandin transmembrane transporter activity 1/149 12/18639 0.0833333333333333 10.4244966442953 0.0918465515099981 0.308242593325221 GO:0016840 carbon-nitrogen lyase activity 1/149 12/18639 0.0833333333333333 10.4244966442953 0.0918465515099981 0.308242593325221 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/149 12/18639 0.0833333333333333 10.4244966442953 0.0918465515099981 0.308242593325221 GO:0019843 rRNA binding 2/149 65/18639 0.0307692307692308 3.84904491481673 0.0953440226058555 0.313746030315058 GO:0120013 lipid transfer activity 2/149 65/18639 0.0307692307692308 3.84904491481673 0.0953440226058555 0.313746030315058 GO:0002020 protease binding 3/149 136/18639 0.0220588235294118 2.75942558231346 0.0956110927596677 0.313746030315058 GO:0004465 lipoprotein lipase activity 1/149 13/18639 0.0769230769230769 9.62261228704182 0.0991109990230177 0.318160670776789 GO:0017154 semaphorin receptor activity 1/149 13/18639 0.0769230769230769 9.62261228704182 0.0991109990230177 0.318160670776789 GO:0071714 icosanoid transmembrane transporter activity 1/149 13/18639 0.0769230769230769 9.62261228704182 0.0991109990230177 0.318160670776789 GO:0016500 protein-hormone receptor activity 2/149 67/18639 0.0298507462686567 3.73414805168787 0.100329259037489 0.31975440110509 GO:0004713 protein tyrosine kinase activity 3/149 140/18639 0.0214285714285714 2.68058485139022 0.102060075346759 0.322947238418672 GO:0005548 phospholipid transporter activity 2/149 68/18639 0.0294117647058824 3.67923410975128 0.102848805298914 0.323134898917864 GO:0019992 diacylglycerol binding 1/149 14/18639 0.0714285714285714 8.9352828379674 0.106317724092575 0.325287232065638 GO:0071933 Arp2/3 complex binding 1/149 14/18639 0.0714285714285714 8.9352828379674 0.106317724092575 0.325287232065638 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/149 14/18639 0.0714285714285714 8.9352828379674 0.106317724092575 0.325287232065638 GO:0008028 monocarboxylic acid transmembrane transporter activity 2/149 70/18639 0.0285714285714286 3.57411313518696 0.107939555561284 0.325287232065638 GO:0016782 transferase activity, transferring sulphur-containing groups 2/149 70/18639 0.0285714285714286 3.57411313518696 0.107939555561284 0.325287232065638 GO:0097110 scaffold protein binding 2/149 70/18639 0.0285714285714286 3.57411313518696 0.107939555561284 0.325287232065638 GO:0051020 GTPase binding 5/149 315/18639 0.0158730158730159 1.9856184084372 0.108730708281959 0.325457457898025 GO:0005041 low-density lipoprotein particle receptor activity 1/149 15/18639 0.0666666666666667 8.33959731543624 0.113467182299834 0.332887163965739 GO:0034483 heparan sulfate sulfotransferase activity 1/149 15/18639 0.0666666666666667 8.33959731543624 0.113467182299834 0.332887163965739 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/149 15/18639 0.0666666666666667 8.33959731543624 0.113467182299834 0.332887163965739 GO:0003678 DNA helicase activity 2/149 74/18639 0.027027027027027 3.38091783058226 0.118315738822529 0.344567759773833 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/149 16/18639 0.0625 7.81837248322148 0.120559825654502 0.344567759773833 GO:0008142 oxysterol binding 1/149 16/18639 0.0625 7.81837248322148 0.120559825654502 0.344567759773833 GO:0140328 floppase activity 1/149 16/18639 0.0625 7.81837248322148 0.120559825654502 0.344567759773833 GO:0008429 phosphatidylethanolamine binding 1/149 17/18639 0.0588235294117647 7.35846821950257 0.127596102622632 0.35550360667815 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/149 17/18639 0.0588235294117647 7.35846821950257 0.127596102622632 0.35550360667815 GO:0046965 nuclear retinoid X receptor binding 1/149 17/18639 0.0588235294117647 7.35846821950257 0.127596102622632 0.35550360667815 GO:0070492 oligosaccharide binding 1/149 17/18639 0.0588235294117647 7.35846821950257 0.127596102622632 0.35550360667815 GO:0033293 monocarboxylic acid binding 2/149 79/18639 0.0253164556962025 3.16693568940617 0.131617174490832 0.356990245283347 GO:0046332 SMAD binding 2/149 79/18639 0.0253164556962025 3.16693568940617 0.131617174490832 0.356990245283347 GO:0003746 translation elongation factor activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.356990245283347 GO:0008409 5'-3' exonuclease activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.356990245283347 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.356990245283347 GO:0030228 lipoprotein particle receptor activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.356990245283347 GO:0035615 clathrin adaptor activity 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.356990245283347 GO:1901611 phosphatidylglycerol binding 1/149 18/18639 0.0555555555555556 6.9496644295302 0.134576458154219 0.356990245283347 GO:0004866 endopeptidase inhibitor activity 3/149 161/18639 0.0186335403726708 2.33094334903497 0.138535943340192 0.364448202522021 GO:0008083 growth factor activity 3/149 162/18639 0.0185185185185185 2.3165548098434 0.140372684372472 0.364448202522021 GO:0015245 fatty acid transmembrane transporter activity 1/149 19/18639 0.0526315789473684 6.58389261744966 0.141501333710582 0.364448202522021 GO:0042834 peptidoglycan binding 1/149 19/18639 0.0526315789473684 6.58389261744966 0.141501333710582 0.364448202522021 GO:0043395 heparan sulfate proteoglycan binding 1/149 19/18639 0.0526315789473684 6.58389261744966 0.141501333710582 0.364448202522021 GO:0001540 amyloid-beta binding 2/149 83/18639 0.0240963855421687 3.0143122826878 0.142492885132484 0.364880624934628 GO:0001972 retinoic acid binding 1/149 20/18639 0.05 6.25469798657718 0.148371167291522 0.375591012057968 GO:0016004 phospholipase activator activity 1/149 20/18639 0.05 6.25469798657718 0.148371167291522 0.375591012057968 GO:0016209 antioxidant activity 2/149 86/18639 0.0232558139534884 2.90916185422194 0.15077099446757 0.379497446301895 GO:0030414 peptidase inhibitor activity 3/149 169/18639 0.0177514792899408 2.22060283547119 0.153455357636915 0.379820841457434 GO:0015125 bile acid transmembrane transporter activity 1/149 21/18639 0.0476190476190476 5.9568552253116 0.155186393462292 0.379820841457434 GO:0036122 BMP binding 1/149 21/18639 0.0476190476190476 5.9568552253116 0.155186393462292 0.379820841457434 GO:0051010 microtubule plus-end binding 1/149 21/18639 0.0476190476190476 5.9568552253116 0.155186393462292 0.379820841457434 GO:0140312 cargo adaptor activity 1/149 21/18639 0.0476190476190476 5.9568552253116 0.155186393462292 0.379820841457434 GO:0004197 cysteine-type endopeptidase activity 2/149 88/18639 0.0227272727272727 2.84304453935326 0.156342233178179 0.380547303834799 GO:0008970 phospholipase A1 activity 1/149 22/18639 0.0454545454545455 5.68608907870653 0.161947443380335 0.389906072921132 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/149 22/18639 0.0454545454545455 5.68608907870653 0.161947443380335 0.389906072921132 GO:0003887 DNA-directed DNA polymerase activity 1/149 23/18639 0.0434782608695652 5.43886781441494 0.168654744821831 0.398090628528405 GO:0004602 glutathione peroxidase activity 1/149 23/18639 0.0434782608695652 5.43886781441494 0.168654744821831 0.398090628528405 GO:0016493 C-C chemokine receptor activity 1/149 23/18639 0.0434782608695652 5.43886781441494 0.168654744821831 0.398090628528405 GO:0005096 GTPase activator activity 4/149 271/18639 0.014760147601476 1.84640530969068 0.172217469686828 0.398090628528405 GO:0004806 triacylglycerol lipase activity 1/149 24/18639 0.0416666666666667 5.21224832214765 0.175308722208033 0.398090628528405 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/149 24/18639 0.0416666666666667 5.21224832214765 0.175308722208033 0.398090628528405 GO:0019957 C-C chemokine binding 1/149 24/18639 0.0416666666666667 5.21224832214765 0.175308722208033 0.398090628528405 GO:0035035 histone acetyltransferase binding 1/149 24/18639 0.0416666666666667 5.21224832214765 0.175308722208033 0.398090628528405 GO:0050431 transforming growth factor beta binding 1/149 24/18639 0.0416666666666667 5.21224832214765 0.175308722208033 0.398090628528405 GO:0060229 lipase activator activity 1/149 24/18639 0.0416666666666667 5.21224832214765 0.175308722208033 0.398090628528405 GO:0070300 phosphatidic acid binding 1/149 24/18639 0.0416666666666667 5.21224832214765 0.175308722208033 0.398090628528405 GO:0004867 serine-type endopeptidase inhibitor activity 2/149 95/18639 0.0210526315789474 2.63355704697987 0.176130390951619 0.398090628528405 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/149 25/18639 0.04 5.00375838926174 0.181909796631402 0.404954974410609 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 1/149 25/18639 0.04 5.00375838926174 0.181909796631402 0.404954974410609 GO:0042974 nuclear retinoic acid receptor binding 1/149 25/18639 0.04 5.00375838926174 0.181909796631402 0.404954974410609 GO:0001637 G protein-coupled chemoattractant receptor activity 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.405469590049777 GO:0004529 DNA exonuclease activity 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.405469590049777 GO:0004950 chemokine receptor activity 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.405469590049777 GO:0051139 metal cation:proton antiporter activity 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.405469590049777 GO:0120014 phospholipid transfer activity 1/149 26/18639 0.0384615384615385 4.81130614352091 0.188458385881532 0.405469590049777 GO:0046943 carboxylic acid transmembrane transporter activity 3/149 188/18639 0.0159574468085106 1.99618020848208 0.190721045313723 0.405469590049777 GO:0005342 organic acid transmembrane transporter activity 3/149 189/18639 0.0158730158730159 1.9856184084372 0.192744123256646 0.405469590049777 GO:0035091 phosphatidylinositol binding 4/149 284/18639 0.0140845070422535 1.7618867567823 0.192897060430008 0.405469590049777 GO:0004364 glutathione transferase activity 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.405469590049777 GO:0005044 scavenger receptor activity 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.405469590049777 GO:0008320 protein transmembrane transporter activity 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.405469590049777 GO:0008395 steroid hydroxylase activity 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.405469590049777 GO:0023026 MHC class II protein complex binding 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.405469590049777 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 1/149 27/18639 0.037037037037037 4.6331096196868 0.194954904470886 0.405469590049777 GO:0005242 inward rectifier potassium channel activity 1/149 28/18639 0.0357142857142857 4.4676414189837 0.201399763660325 0.416916333184692 GO:0003785 actin monomer binding 1/149 29/18639 0.0344827586206897 4.31358481832909 0.207793371484441 0.424204901233213 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 1/149 29/18639 0.0344827586206897 4.31358481832909 0.207793371484441 0.424204901233213 GO:0051861 glycolipid binding 1/149 29/18639 0.0344827586206897 4.31358481832909 0.207793371484441 0.424204901233213 GO:0001968 fibronectin binding 1/149 30/18639 0.0333333333333333 4.16979865771812 0.214136132776693 0.433161218356507 GO:0048019 receptor antagonist activity 1/149 30/18639 0.0333333333333333 4.16979865771812 0.214136132776693 0.433161218356507 GO:0005164 tumor necrosis factor receptor binding 1/149 31/18639 0.032258064516129 4.03528902359818 0.220428449194355 0.44185431218597 GO:0070273 phosphatidylinositol-4-phosphate binding 1/149 31/18639 0.032258064516129 4.03528902359818 0.220428449194355 0.44185431218597 GO:0005200 structural constituent of cytoskeleton 2/149 112/18639 0.0178571428571429 2.23382070949185 0.225526040211728 0.448281824217699 GO:0022884 macromolecule transmembrane transporter activity 1/149 32/18639 0.03125 3.90918624161074 0.226670719243261 0.448281824217699 GO:0031369 translation initiation factor binding 1/149 32/18639 0.03125 3.90918624161074 0.226670719243261 0.448281824217699 GO:0005516 calmodulin binding 3/149 207/18639 0.0144927536231884 1.81295593813831 0.229996493425967 0.452837540389792 GO:0071889 14-3-3 protein binding 1/149 33/18639 0.0303030303030303 3.79072605247102 0.232863338302365 0.455370190223426 GO:0035401 histone H3Y41 kinase activity 2/149 115/18639 0.0173913043478261 2.17554712576598 0.23436659903147 0.455370190223426 GO:0140801 histone H2AXY142 kinase activity 2/149 115/18639 0.0173913043478261 2.17554712576598 0.23436659903147 0.455370190223426 GO:0019825 oxygen binding 1/149 34/18639 0.0294117647058824 3.67923410975128 0.239006698648111 0.462357936686084 GO:0034061 DNA polymerase activity 1/149 35/18639 0.0285714285714286 3.57411313518696 0.24510118947861 0.472086204082714 GO:0000993 RNA polymerase II complex binding 1/149 36/18639 0.0277777777777778 3.4748322147651 0.251147196937634 0.477503039671125 GO:0004190 aspartic-type endopeptidase activity 1/149 36/18639 0.0277777777777778 3.4748322147651 0.251147196937634 0.477503039671125 GO:0055106 ubiquitin-protein transferase regulator activity 1/149 36/18639 0.0277777777777778 3.4748322147651 0.251147196937634 0.477503039671125 GO:0023023 MHC protein complex binding 1/149 37/18639 0.027027027027027 3.38091783058226 0.257145104138424 0.484745877163072 GO:0070001 aspartic-type peptidase activity 1/149 37/18639 0.027027027027027 3.38091783058226 0.257145104138424 0.484745877163072 GO:0000146 microfilament motor activity 1/149 38/18639 0.0263157894736842 3.29194630872483 0.26309529118731 0.487661983246771 GO:0005501 retinoid binding 1/149 38/18639 0.0263157894736842 3.29194630872483 0.26309529118731 0.487661983246771 GO:0019840 isoprenoid binding 1/149 38/18639 0.0263157894736842 3.29194630872483 0.26309529118731 0.487661983246771 GO:0043531 ADP binding 1/149 38/18639 0.0263157894736842 3.29194630872483 0.26309529118731 0.487661983246771 GO:0000217 DNA secondary structure binding 1/149 39/18639 0.0256410256410256 3.20753742901394 0.268998135207152 0.496525724569869 GO:0031490 chromatin DNA binding 2/149 128/18639 0.015625 1.95459312080537 0.272836954733694 0.501521871149488 GO:0071855 neuropeptide receptor binding 1/149 40/18639 0.025 3.12734899328859 0.2748540103606 0.503141845412174 GO:0045296 cadherin binding 4/149 334/18639 0.0119760479041916 1.49813125426998 0.278327543223677 0.505422099706561 GO:0001530 lipopolysaccharide binding 1/149 41/18639 0.024390243902439 3.05107218857423 0.28066328787317 0.505422099706561 GO:0140318 protein transporter activity 1/149 41/18639 0.024390243902439 3.05107218857423 0.28066328787317 0.505422099706561 GO:0140828 metal cation:monoatomic cation antiporter activity 1/149 41/18639 0.024390243902439 3.05107218857423 0.28066328787317 0.505422099706561 GO:0140097 catalytic activity, acting on DNA 4/149 336/18639 0.0119047619047619 1.4892138063279 0.281883749829342 0.505564782082584 GO:0031492 nucleosomal DNA binding 1/149 42/18639 0.0238095238095238 2.9784276126558 0.286426336056141 0.509585810734419 GO:0043175 RNA polymerase core enzyme binding 1/149 42/18639 0.0238095238095238 2.9784276126558 0.286426336056141 0.509585810734419 GO:0008200 ion channel inhibitor activity 1/149 43/18639 0.0232558139534884 2.90916185422194 0.292143520329283 0.51561585460507 GO:0048156 tau protein binding 1/149 43/18639 0.0232558139534884 2.90916185422194 0.292143520329283 0.51561585460507 GO:0016248 channel inhibitor activity 1/149 44/18639 0.0227272727272727 2.84304453935326 0.297815203243401 0.520284686455786 GO:0030547 signaling receptor inhibitor activity 1/149 44/18639 0.0227272727272727 2.84304453935326 0.297815203243401 0.520284686455786 GO:0016922 nuclear receptor binding 2/149 137/18639 0.0145985401459854 1.82618919316122 0.299459693914361 0.520284686455786 GO:0042605 peptide antigen binding 1/149 45/18639 0.0222222222222222 2.77986577181208 0.303441744502704 0.520284686455786 GO:0051539 4 iron, 4 sulfur cluster binding 1/149 45/18639 0.0222222222222222 2.77986577181208 0.303441744502704 0.520284686455786 GO:0140303 intramembrane lipid transporter activity 1/149 45/18639 0.0222222222222222 2.77986577181208 0.303441744502704 0.520284686455786 GO:0141110 transporter inhibitor activity 1/149 45/18639 0.0222222222222222 2.77986577181208 0.303441744502704 0.520284686455786 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 4/149 349/18639 0.0114613180515759 1.43374165881425 0.305158714669753 0.520284686455786 GO:0070851 growth factor receptor binding 2/149 139/18639 0.0143884892086331 1.7999130896625 0.305358958190755 0.520284686455786 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1/149 46/18639 0.0217391304347826 2.71943390720747 0.309023500987005 0.524511153016258 GO:0020037 heme binding 2/149 142/18639 0.0140845070422535 1.7618867567823 0.314190737167783 0.525850740606683 GO:0005504 fatty acid binding 1/149 47/18639 0.0212765957446809 2.66157361130944 0.314560826773749 0.525850740606683 GO:0043495 protein-membrane adaptor activity 1/149 47/18639 0.0212765957446809 2.66157361130944 0.314560826773749 0.525850740606683 GO:0140359 ABC-type transporter activity 1/149 47/18639 0.0212765957446809 2.66157361130944 0.314560826773749 0.525850740606683 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 1/149 48/18639 0.0208333333333333 2.60612416107383 0.320054073159868 0.530121145001384 GO:0019903 protein phosphatase binding 2/149 144/18639 0.0138888888888889 1.73741610738255 0.320065434686698 0.530121145001384 GO:0042277 peptide binding 3/149 249/18639 0.0120481927710843 1.5071561413439 0.320705342799934 0.530121145001384 GO:0032813 tumor necrosis factor receptor superfamily binding 1/149 50/18639 0.02 2.50187919463087 0.330909719145334 0.544361883017221 GO:0019209 kinase activator activity 2/149 148/18639 0.0135135135135135 1.69045891529113 0.331778122832166 0.544361883017221 GO:0000510 H3-H4 histone complex chaperone activity 2/149 151/18639 0.0132450331125828 1.65687363882839 0.340526254099479 0.548799819204908 GO:0140584 chromatin extrusion motor activity 2/149 151/18639 0.0132450331125828 1.65687363882839 0.340526254099479 0.548799819204908 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 2/149 151/18639 0.0132450331125828 1.65687363882839 0.340526254099479 0.548799819204908 GO:0140849 ATP-dependent H2AZ histone chaperone activity 2/149 151/18639 0.0132450331125828 1.65687363882839 0.340526254099479 0.548799819204908 GO:0015616 DNA translocase activity 2/149 152/18639 0.0131578947368421 1.64597315436242 0.343434676025593 0.548799819204908 GO:0046906 tetrapyrrole binding 2/149 152/18639 0.0131578947368421 1.64597315436242 0.343434676025593 0.548799819204908 GO:0140674 ATP-dependent histone chaperone activity 2/149 152/18639 0.0131578947368421 1.64597315436242 0.343434676025593 0.548799819204908 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 5/149 484/18639 0.0103305785123967 1.2922929724333 0.345131337554577 0.548799819204908 GO:0061775 cohesin loader activity 2/149 153/18639 0.0130718954248366 1.63521515988946 0.346339079454597 0.548799819204908 GO:0017046 peptide hormone binding 1/149 53/18639 0.0188679245283019 2.3602633911612 0.346871217556149 0.548799819204908 GO:0140297 DNA-binding transcription factor binding 5/149 488/18639 0.0102459016393443 1.28170040708549 0.351472948240844 0.551222470579686 GO:0051287 NAD binding 1/149 54/18639 0.0185185185185185 2.3165548098434 0.352107211776752 0.551222470579686 GO:0004386 helicase activity 2/149 155/18639 0.0129032258064516 1.61411560943927 0.352135348022689 0.551222470579686 GO:0001216 DNA-binding transcription activator activity 5/149 491/18639 0.010183299389002 1.27386924370207 0.356233674088801 0.555384451797682 GO:0140313 molecular sequestering activity 1/149 55/18639 0.0181818181818182 2.27443563148261 0.357301509621534 0.555384451797682 GO:0140658 ATP-dependent chromatin remodeler activity 2/149 158/18639 0.0126582278481013 1.58346784470308 0.360796651000209 0.5588563510248 GO:0030170 pyridoxal phosphate binding 1/149 56/18639 0.0178571428571429 2.23382070949185 0.362454440910083 0.559468004610337 GO:0008514 organic anion transmembrane transporter activity 3/149 269/18639 0.0111524163568773 1.39509992265662 0.364392056751045 0.560505837294141 GO:0003689 DNA clamp loader activity 2/149 160/18639 0.0125 1.5636744966443 0.366547471050493 0.561489260212848 GO:0070279 vitamin B6 binding 1/149 57/18639 0.0175438596491228 2.19463087248322 0.367566332870713 0.561489260212848 GO:0001786 phosphatidylserine binding 1/149 59/18639 0.0169491525423729 2.12023660561938 0.377668294886269 0.571498934836601 GO:0070063 RNA polymerase binding 1/149 59/18639 0.0169491525423729 2.12023660561938 0.377668294886269 0.571498934836601 GO:0140713 histone chaperone activity 2/149 164/18639 0.0121951219512195 1.52553609428712 0.377989137487864 0.571498934836601 GO:0001098 basal transcription machinery binding 1/149 60/18639 0.0166666666666667 2.08489932885906 0.382659006622649 0.572695743019708 GO:0001099 basal RNA polymerase II transcription machinery binding 1/149 60/18639 0.0166666666666667 2.08489932885906 0.382659006622649 0.572695743019708 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/149 60/18639 0.0166666666666667 2.08489932885906 0.382659006622649 0.572695743019708 GO:0019905 syntaxin binding 1/149 61/18639 0.0163934426229508 2.05072065133678 0.387609962433684 0.57815223352903 GO:0015179 L-amino acid transmembrane transporter activity 1/149 62/18639 0.0161290322580645 2.01764451179909 0.392521476891504 0.583513470680995 GO:0005507 copper ion binding 1/149 63/18639 0.0158730158730159 1.9856184084372 0.39739386209596 0.588780872603713 GO:0004536 DNA nuclease activity 1/149 64/18639 0.015625 1.95459312080537 0.402227427693919 0.591661501473357 GO:0015291 secondary active transmembrane transporter activity 3/149 287/18639 0.0104529616724739 1.30760236653182 0.403344861049557 0.591661501473357 GO:0019207 kinase regulator activity 3/149 287/18639 0.0104529616724739 1.30760236653182 0.403344861049557 0.591661501473357 GO:0004175 endopeptidase activity 4/149 405/18639 0.00987654320987654 1.23549589858315 0.406600867161462 0.594469254628804 GO:0004252 serine-type endopeptidase activity 2/149 176/18639 0.0113636363636364 1.42152226967663 0.411778458255356 0.600058740155008 GO:1990841 promoter-specific chromatin binding 1/149 68/18639 0.0147058823529412 1.83961705487564 0.421179602172015 0.611746110695746 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 2/149 181/18639 0.0110497237569061 1.38225369869109 0.425594413077339 0.616138316971441 GO:0016887 ATP hydrolysis activity 4/149 417/18639 0.00959232613908873 1.199942059775 0.428153991295231 0.61782481480061 GO:0140299 molecular sensor activity 1/149 71/18639 0.0140845070422535 1.7618867567823 0.435000941887113 0.625666939142828 GO:0005518 collagen binding 1/149 72/18639 0.0138888888888889 1.73741610738255 0.43953480981359 0.626760329199334 GO:0008234 cysteine-type peptidase activity 2/149 187/18639 0.0106951871657754 1.33790331263683 0.441950342940947 0.626760329199334 GO:0031406 carboxylic acid binding 2/149 187/18639 0.0106951871657754 1.33790331263683 0.441950342940947 0.626760329199334 GO:0004521 RNA endonuclease activity 1/149 73/18639 0.0136986301369863 1.71361588673347 0.44403253768227 0.626760329199334 GO:0043539 protein serine/threonine kinase activator activity 1/149 73/18639 0.0136986301369863 1.71361588673347 0.44403253768227 0.626760329199334 GO:0140597 protein carrier chaperone 2/149 188/18639 0.0106382978723404 1.33078680565472 0.444651733238013 0.626760329199334 GO:0043177 organic acid binding 2/149 189/18639 0.0105820105820106 1.3237456056248 0.447345932275247 0.626760329199334 GO:0031491 nucleosome binding 1/149 74/18639 0.0135135135135135 1.69045891529113 0.448494411639253 0.626760329199334 GO:0035064 methylated histone binding 1/149 74/18639 0.0135135135135135 1.69045891529113 0.448494411639253 0.626760329199334 GO:0019902 phosphatase binding 2/149 190/18639 0.0105263157894737 1.31677852348993 0.450032882001631 0.626932599769568 GO:0003725 double-stranded RNA binding 1/149 75/18639 0.0133333333333333 1.66791946308725 0.452920715580311 0.627012115631493 GO:0044183 protein folding chaperone 1/149 75/18639 0.0133333333333333 1.66791946308725 0.452920715580311 0.627012115631493 GO:0051536 iron-sulfur cluster binding 1/149 76/18639 0.0131578947368421 1.64597315436242 0.457311731168467 0.627210826339415 GO:0098631 cell adhesion mediator activity 1/149 76/18639 0.0131578947368421 1.64597315436242 0.457311731168467 0.627210826339415 GO:0140034 methylation-dependent protein binding 1/149 76/18639 0.0131578947368421 1.64597315436242 0.457311731168467 0.627210826339415 GO:0008236 serine-type peptidase activity 2/149 194/18639 0.0103092783505155 1.28962845084066 0.46070707443034 0.629288639594415 GO:0051540 metal cluster binding 1/149 77/18639 0.012987012987013 1.62459687963044 0.461667737851433 0.629288639594415 GO:0017171 serine hydrolase activity 2/149 198/18639 0.0101010101010101 1.26357535082367 0.471260983126032 0.640394526149792 GO:0048306 calcium-dependent protein binding 1/149 80/18639 0.0125 1.5636744966443 0.474528466079129 0.642862723159187 GO:0016829 lyase activity 2/149 200/18639 0.01 1.25093959731544 0.47649185430295 0.643554547122581 GO:0015101 organic cation transmembrane transporter activity 1/149 81/18639 0.0123456790123457 1.54436987322893 0.478747187915123 0.644635271265652 GO:0046873 metal ion transmembrane transporter activity 4/149 450/18639 0.00888888888888889 1.11194630872483 0.486255177526246 0.649934327080228 GO:0003714 transcription corepressor activity 2/149 204/18639 0.00980392156862745 1.22641136991709 0.486859649105538 0.649934327080228 GO:0030165 PDZ domain binding 1/149 83/18639 0.0120481927710843 1.5071561413439 0.487083965215882 0.649934327080228 GO:0004527 exonuclease activity 1/149 84/18639 0.0119047619047619 1.4892138063279 0.491202551612888 0.651505180732063 GO:0051117 ATPase binding 1/149 84/18639 0.0119047619047619 1.4892138063279 0.491202551612888 0.651505180732063 GO:0022804 active transmembrane transporter activity 4/149 457/18639 0.0087527352297593 1.09491430837237 0.498292508688897 0.656796701980462 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1/149 86/18639 0.0116279069767442 1.45458092711097 0.499341431601769 0.656796701980462 GO:0004518 nuclease activity 2/149 209/18639 0.00956937799043062 1.19707138499085 0.499639929046085 0.656796701980462 GO:0008094 ATP-dependent activity, acting on DNA 2/149 210/18639 0.00952380952380952 1.19137104506232 0.502171688709955 0.658171769522219 GO:0072341 modified amino acid binding 1/149 91/18639 0.010989010989011 1.37465889814883 0.519127260460205 0.678387540955371 GO:0051213 dioxygenase activity 1/149 93/18639 0.010752688172043 1.34509634119939 0.526822339639938 0.686418519001448 GO:0042562 hormone binding 1/149 94/18639 0.0106382978723404 1.33078680565472 0.530623885600989 0.689344226748498 GO:0004896 cytokine receptor activity 1/149 96/18639 0.0104166666666667 1.30306208053691 0.538136202306253 0.697059466730029 GO:0141003 histone H2AX kinase activity 3/149 354/18639 0.00847457627118644 1.06011830280969 0.540294782398342 0.697815127120891 GO:0005249 voltage-gated potassium channel activity 1/149 98/18639 0.0102040816326531 1.27646897685249 0.545529079247044 0.699090642635737 GO:0042626 ATPase-coupled transmembrane transporter activity 1/149 98/18639 0.0102040816326531 1.27646897685249 0.545529079247044 0.699090642635737 GO:0140996 histone H3 kinase activity 3/149 357/18639 0.00840336134453781 1.05120974564322 0.546016619304661 0.699090642635737 GO:0035173 histone kinase activity 3/149 360/18639 0.00833333333333333 1.04244966442953 0.551697407303071 0.700344542982426 GO:0030695 GTPase regulator activity 4/149 489/18639 0.0081799591002045 1.02326347428666 0.551697794096373 0.700344542982426 GO:0043130 ubiquitin binding 1/149 100/18639 0.01 1.25093959731544 0.552804402790889 0.700344542982426 GO:0060589 nucleoside-triphosphatase regulator activity 4/149 490/18639 0.00816326530612245 1.02117518148199 0.553319616351804 0.700344542982426 GO:0015171 amino acid transmembrane transporter activity 1/149 102/18639 0.00980392156862745 1.22641136991709 0.559964029712525 0.706512920562252 GO:0003712 transcription coregulator activity 4/149 495/18639 0.00808080808080808 1.01086028065894 0.561382726947884 0.706512920562252 GO:0046982 protein heterodimerization activity 3/149 369/18639 0.00813008130081301 1.01702406285808 0.568488399775554 0.713428784987451 GO:0000149 SNARE binding 1/149 106/18639 0.00943396226415094 1.1801316955806 0.573943475583711 0.714204942931416 GO:0004497 monooxygenase activity 1/149 106/18639 0.00943396226415094 1.1801316955806 0.573943475583711 0.714204942931416 GO:0008013 beta-catenin binding 1/149 106/18639 0.00943396226415094 1.1801316955806 0.573943475583711 0.714204942931416 GO:0004620 phospholipase activity 1/149 109/18639 0.00917431192660551 1.14765100671141 0.584137742071947 0.724854397024852 GO:0042393 histone binding 2/149 247/18639 0.00809716599190283 1.01290655653072 0.589898891118073 0.729036019433551 GO:1902936 phosphatidylinositol bisphosphate binding 1/149 111/18639 0.00900900900900901 1.12697261019409 0.590798941256535 0.729036019433551 GO:0043022 ribosome binding 1/149 112/18639 0.00892857142857143 1.11691035474593 0.594089688112794 0.729296794323387 GO:0140104 molecular carrier activity 2/149 249/18639 0.00803212851405622 1.00477076089593 0.594302805306417 0.729296794323387 GO:0001221 transcription coregulator binding 1/149 115/18639 0.00869565217391304 1.08777356288299 0.603805035729838 0.736875016055973 GO:0017124 SH3 domain binding 1/149 115/18639 0.00869565217391304 1.08777356288299 0.603805035729838 0.736875016055973 GO:0009055 electron transfer activity 1/149 116/18639 0.00862068965517241 1.07839620458227 0.606991877107308 0.737083928597819 GO:0019887 protein kinase regulator activity 2/149 255/18639 0.00784313725490196 0.981129095933675 0.607303914081725 0.737083928597819 GO:0003713 transcription coactivator activity 2/149 256/18639 0.0078125 0.977296560402685 0.609440050176778 0.737655579858777 GO:0032182 ubiquitin-like protein binding 1/149 120/18639 0.00833333333333333 1.04244966442953 0.619486624801082 0.743366126758571 GO:0003730 mRNA 3'-UTR binding 2/149 262/18639 0.00763358778625954 0.954915723141554 0.622072776895719 0.743366126758571 GO:0003697 single-stranded DNA binding 1/149 121/18639 0.00826446280991736 1.03383437794664 0.622548155818126 0.743366126758571 GO:0004540 RNA nuclease activity 1/149 121/18639 0.00826446280991736 1.03383437794664 0.622548155818126 0.743366126758571 GO:0051082 unfolded protein binding 1/149 121/18639 0.00826446280991736 1.03383437794664 0.622548155818126 0.743366126758571 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/149 122/18639 0.00819672131147541 1.02536032566839 0.625585218394166 0.744984547711332 GO:0005267 potassium channel activity 1/149 124/18639 0.00806451612903226 1.00882225589955 0.631586713677236 0.750115051364652 GO:0004519 endonuclease activity 1/149 127/18639 0.0078740157480315 0.984991808909792 0.640410249927345 0.758560804058325 GO:0035591 signaling adaptor activity 1/149 129/18639 0.00775193798449612 0.969720618073982 0.646175665293042 0.763348852599513 GO:0016298 lipase activity 1/149 130/18639 0.00769230769230769 0.962261228704182 0.649023846053244 0.764674371812731 GO:0005262 calcium channel activity 1/149 131/18639 0.00763358778625954 0.954915723141554 0.651849252446785 0.765966097702721 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 1/149 132/18639 0.00757575757575758 0.947681513117755 0.654652065359333 0.767224510460805 GO:0030246 carbohydrate binding 2/149 280/18639 0.00714285714285714 0.89352828379674 0.658088249847615 0.769216608660932 GO:0051087 protein-folding chaperone binding 1/149 134/18639 0.00746268656716418 0.933537012921967 0.660190627160337 0.769643283768498 GO:0015297 antiporter activity 1/149 135/18639 0.00740740740740741 0.92662192393736 0.662926730729811 0.769918905847714 GO:0016779 nucleotidyltransferase activity 1/149 136/18639 0.00735294117647059 0.919808527437821 0.665640950202425 0.769918905847714 GO:0099094 ligand-gated monoatomic cation channel activity 1/149 136/18639 0.00735294117647059 0.919808527437821 0.665640950202425 0.769918905847714 GO:0030295 protein kinase activator activity 1/149 139/18639 0.00719424460431655 0.899956544831249 0.67365403580669 0.777158171516572 GO:0022843 voltage-gated monoatomic cation channel activity 1/149 143/18639 0.00699300699300699 0.87478293518562 0.68404216466008 0.787092672582897 GO:0015085 calcium ion transmembrane transporter activity 1/149 147/18639 0.00680272108843537 0.850979317901657 0.694101771194762 0.7965986648686 GO:0019842 vitamin binding 1/149 150/18639 0.00666666666666667 0.833959731543624 0.701437104533541 0.80293704730842 GO:0003774 cytoskeletal motor activity 1/149 153/18639 0.0065359477124183 0.81760757994473 0.708597691480209 0.809043240530239 GO:0005506 iron ion binding 1/149 154/18639 0.00649350649350649 0.812298439815218 0.710946438854949 0.809638232423503 GO:0140375 immune receptor activity 1/149 156/18639 0.00641025641025641 0.801884357253485 0.715587667479651 0.812834196649963 GO:0015079 potassium ion transmembrane transporter activity 1/149 160/18639 0.00625 0.781837248322148 0.724649206607066 0.818927547262577 GO:0099106 ion channel regulator activity 1/149 160/18639 0.00625 0.781837248322148 0.724649206607066 0.818927547262577 GO:0015399 primary active transmembrane transporter activity 1/149 166/18639 0.00602409638554217 0.75357807067195 0.737706539455236 0.831562333279057 GO:0016247 channel regulator activity 1/149 168/18639 0.00595238095238095 0.74460690316395 0.741920815615812 0.834190155628946 GO:0141108 transporter regulator activity 1/149 170/18639 0.00588235294117647 0.735846821950257 0.746067828061718 0.836729235016054 GO:0005244 voltage-gated monoatomic ion channel activity 1/149 173/18639 0.00578034682080925 0.723086472436668 0.752164555529129 0.839317123676081 GO:0140030 modification-dependent protein binding 1/149 173/18639 0.00578034682080925 0.723086472436668 0.752164555529129 0.839317123676081 GO:0003823 antigen binding 1/149 174/18639 0.00574712643678161 0.718930803054848 0.75416431082135 0.839434144959443 GO:0022832 voltage-gated channel activity 1/149 175/18639 0.00571428571428571 0.714822627037392 0.756148037747298 0.839532783764543 GO:0043021 ribonucleoprotein complex binding 1/149 177/18639 0.00564971751412429 0.706745535206461 0.760067915926685 0.839685998229789 GO:0005261 monoatomic cation channel activity 2/149 341/18639 0.00586510263929619 0.733688913381487 0.760076941964211 0.839685998229789 GO:0015078 proton transmembrane transporter activity 1/149 185/18639 0.00540540540540541 0.676183566116452 0.775131327528038 0.854063268714769 GO:0015276 ligand-gated monoatomic ion channel activity 1/149 186/18639 0.00537634408602151 0.672548170599697 0.776946946483187 0.854063268714769 GO:0022834 ligand-gated channel activity 1/149 188/18639 0.00531914893617021 0.66539340282736 0.780534614562353 0.855883253096837 GO:0015631 tubulin binding 2/149 385/18639 0.00519480519480519 0.649838751852175 0.816392664532899 0.891339697645798 GO:0000287 magnesium ion binding 1/149 230/18639 0.00434782608695652 0.543886781441494 0.843935629497829 0.891339697645798 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 1/149 243/18639 0.00411522633744856 0.514789957742978 0.859587353832786 0.891339697645798 GO:0004676 3-phosphoinositide-dependent protein kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0004711 ribosomal protein S6 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0035175 histone H3S10 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0035979 histone H2AXS139 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0044022 histone H3S28 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0044023 histone H4S1 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0044024 histone H2AS1 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0044025 histone H2BS14 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0072354 histone H3T3 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0072371 histone H2AS121 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0072518 Rho-dependent protein serine/threonine kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0140823 histone H2BS36 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0140855 histone H3S57 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0140995 histone H2A kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0140997 histone H4 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0140998 histone H2B kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:1990244 histone H2AT120 kinase activity 1/149 245/18639 0.00408163265306122 0.510587590740994 0.8618527724734 0.891339697645798 GO:0004677 DNA-dependent protein kinase activity 1/149 246/18639 0.0040650406504065 0.508512031429039 0.86297182960624 0.891339697645798 GO:0140857 histone H3T45 kinase activity 1/149 246/18639 0.0040650406504065 0.508512031429039 0.86297182960624 0.891339697645798 GO:0035402 histone H3T11 kinase activity 1/149 247/18639 0.00404858299595142 0.506453278265359 0.864081882201721 0.891339697645798 GO:0035403 histone H3T6 kinase activity 1/149 247/18639 0.00404858299595142 0.506453278265359 0.864081882201721 0.891339697645798 GO:0004674 protein serine/threonine kinase activity 2/149 433/18639 0.0046189376443418 0.577801199683804 0.864158237794212 0.891339697645798 GO:0004679 AMP-activated protein kinase activity 1/149 248/18639 0.00403225806451613 0.504411127949773 0.865183002229556 0.891339697645798 GO:0005216 monoatomic ion channel activity 2/149 448/18639 0.00446428571428571 0.558455177372963 0.87658695037155 0.900993083560549 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 1/149 268/18639 0.00373134328358209 0.466768506460984 0.885435485784597 0.907981296765224 GO:0008017 microtubule binding 1/149 276/18639 0.0036231884057971 0.453238984534578 0.892662700423893 0.91294499603029 GO:0001217 DNA-binding transcription repressor activity 1/149 278/18639 0.00359712230215827 0.449978272415625 0.894397580761052 0.91294499603029 GO:0031625 ubiquitin protein ligase binding 1/149 302/18639 0.0033112582781457 0.414218409707098 0.913165586339814 0.929959436203535 GO:0022836 gated channel activity 1/149 318/18639 0.00314465408805031 0.3933772318602 0.923796459660373 0.938628054196205 GO:0044389 ubiquitin-like protein ligase binding 1/149 322/18639 0.0031055900621118 0.388490558172496 0.926245555551212 0.93896288583338 GO:0003924 GTPase activity 1/149 331/18639 0.00302114803625378 0.377927370790162 0.931473874731725 0.942107138141904 GO:0106310 protein serine kinase activity 1/149 361/18639 0.00277008310249307 0.346520664076298 0.946383043125277 0.955006123244869 GO:0005525 GTP binding 1/149 378/18639 0.00264550264550265 0.3309364014062 0.953350866840134 0.959850986386771 GO:0140098 catalytic activity, acting on RNA 1/149 387/18639 0.00258397932816537 0.323240206024661 0.956667553472312 0.96100618183273 GO:0019001 guanyl nucleotide binding 1/149 400/18639 0.0025 0.312734899328859 0.961048954964951 0.961048954964951 GO:0032561 guanyl ribonucleotide binding 1/149 400/18639 0.0025 0.312734899328859 0.961048954964951 0.961048954964951