category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	14/193	174/9376	3.90876064558394	HSP90B1/PDIA3/ERLEC1/SIL1/SEC63/SEC62/MAN1A2/ATF6/CKAP4/ATF4/RPN2/TMEM258/UBXN4/DNAJC10	5.61453115360015
Genetic Information Processing	Translation	hsa03010	Ribosome	15/193	222/9376	3.28245343789385	RPS26/RPL34/RPL6/RPS4Y1/RPL22/RPL4/MRPS35/RPS16/RPS6/RPL14/RPS12/RPL10A/RPS27/MRPS10/RPL5	4.98936137227389
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	14/193	238/9376	2.85766534593112	RPS26/RPL34/RPL6/FOS/RPS4Y1/RPL22/RPL4/RPS16/RPS6/RPL14/RPS12/RPL10A/RPS27/RPL5	4.20825823334958
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	13/193	248/9376	2.546548554237	HSP90B1/TCF7L2/TNFSF10/TUBA1C/FOS/DYNC1I2/ACBD3/ARPC2/TXN/ANXA2/DYNLL1/TUBB2A/DYNC1LI2	3.57827393196469
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/193	44/9376	5.52048987282148	MAN1A2/ALG11/RPN2/MAN2A1/TMEM258	4.35708943371297
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/193	233/9376	2.50199025995686	TPM1/FN1/COL11A1/DSP/ITGB1/TNNI2/DAAM1/CSRP2/PDLIM5/FBN1/PKP2/NID2	3.36567919039171
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/193	50/9376	4.8580310880829	SAT1/AMD1/AOC1/P4HA1/MAOA	3.96529059575182
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/193	31/9376	6.26842721042955	SRP14/SEC63/SEC62/SPCS2	4.25935833917558
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/193	56/9376	4.33752775721688	MAN1A2/ALG11/RPN2/MAN2A1/TMEM258	3.6314740420928
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	15/193	362/9376	2.01299630721667	IGF2/HSP90B1/LAMA3/FN1/YWHAE/LAMB3/EIF4E2/ITGB1/LAMB1/FOXO3/RPS6/FLT1/ATF4/FGFR1/CSH1	2.84954402490521
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	12/193	268/9376	2.17523780063413	TUBA1C/PSMD1/ATF6/PSMC3/TXN/PSMC1/SLC39A6/ATF4/GNAS/MAOA/NDUFA13/TUBB2A	2.82978629131228
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/193	117/9376	2.90651432620345	MORF4L2/MORF4L1/SMARCA1/RSF1/SMARCE1/ZNHIT1/MBD2	3.00831259809478
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/193	44/9376	4.41639189825718	DYNC1I2/GNAS/DYNLL1/DYNC1LI2	3.292900871389
NA	NA	hsa04518	Integrin signaling	8/193	154/9376	2.52365251328982	LAMA3/FN1/LAMB3/ITGB1/LAMB1/FBN1/FLNB/FLT1	2.76379441192039
NA	NA	hsa04382	Cornified envelope formation	10/193	217/9376	2.23872400372484	LAMA3/LAMB3/DSP/S100A13/PADI1/COL17A1/S100A6/UGCG/PKP2/PKP3	2.67640844340197
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/193	75/9376	3.23868739205527	HSP90B1/GPX7/GPX3/ATF4/GNAS	2.82183271031349
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/193	103/9376	2.82992102218421	IL1R2/LAMA3/FN1/LAMB3/LAMB1/GNAS	2.70715317395458
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	9/193	205/9376	2.13279413623152	PDIA3/CIR1/HLA-G/PSMD1/PSMC3/PSMC1/SNW1/USP7/HES1	2.37734152710389
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/193	89/9376	2.72923094836118	LAMA3/FN1/LAMB3/ITGB1/LAMB1	2.37619611053115
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/193	36/9376	4.04835924006908	GALNT1/GALNT7/GALNT6	2.65653754874297
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/193	62/9376	3.13421360521478	CIR1/SNW1/TLE6/HES1	2.44420491242961
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	7/193	155/9376	2.19394952365034	TUBA1C/ITGB1/HLA-G/DYNC1I2/TUBB2A/DYNC1LI2/ATP6V1G1	2.17287531044423
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	12/193	333/9376	1.75064183354339	LAMA3/TCF7L2/FN1/LAMB3/PARD3/ITGB1/LAMB1/HLA-G/PSMC1/GNAS/HES1/ATP6V1G1	2.02195095035984
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	5/193	93/9376	2.61184467101231	LAMA3/FN1/LAMB3/ITGB1/LAMB1	2.26460513284118
NA	NA	hsa04517	IgSF CAM signaling	11/193	299/9376	1.78723551735491	TUBA1C/PARD3/ITGB1/EZR/IQGAP1/IL1RAP/ARPC2/TRIO/FGFR1/DYNLL1/TUBB2A	2.00558515653766
Cellular Processes	Cell motility	hsa04814	Motor proteins	8/193	194/9376	2.00331178890017	TPM1/TUBA1C/TNNI2/DYNC1I2/KIF21A/DYNLL1/TUBB2A/DYNC1LI2	2.04710508240859
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/193	69/9376	2.81624990613502	FOS/ATF4/GNAS/MAOA	2.19516562770245
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	8/193	200/9376	1.94321243523316	TNFSF10/TUBA1C/ITGB1/FOS/EZR/ARPC2/WIPF2/TUBB2A	1.95465364523228
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	8/193	204/9376	1.90511023062075	IGF2/FN1/ITGB1/EZR/IQGAP1/RPS6/CD63/FGFR1	1.89477015338748
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	6/193	137/9376	2.1276048560947	TNFSF10/TUBA1C/FOS/CTSV/ATF4/CSF2RB	1.92742167283441
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/193	243/9376	1.79927077336404	SYF2/RBM25/SNRPB2/CDC5L/SNRNP27/SNW1/ACIN1/CWC15/PRPF38B	1.83004741084105
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/193	105/9376	2.31334813718233	TOMM20/FOXO3/TBC1D15/ATF4/TAX1BP1	1.96192870759419
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/193	106/9376	2.29152409815231	HSP90B1/IL1R2/TCF7L2/ATF4/FGFR1	1.9385971952085
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/193	46/9376	3.16828114440189	PSMD1/PSMC3/PSMC1	2.13710415003164
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/193	22/9376	4.41639189825718	AOC1/MAOA	2.32569276305455
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	12/193	368/9376	1.58414057220095	TUBA1C/GPX7/PSMD1/ATF6/PSMC3/PSMC1/GPX3/ATF4/CHMP2B/ATXN2/NDUFA13/TUBB2A	1.65729222482344
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	3/193	49/9376	2.97430474780586	GALNT1/GALNT7/GALNT6	2.00869150130535
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/193	49/9376	2.97430474780586	ATF4/GNAS/MAOA	2.00869150130535
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/193	115/9376	2.11218742960126	GATA3/FOS/ATF4/GNAS/FGFR1	1.73968236391185
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	4/193	86/9376	2.25954934329437	TCF7L2/DSP/ITGB1/PKP2	1.70109494874187
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/193	88/9376	2.20819594912859	CLU/SERPINE2/SERPING1/TFPI	1.65078155838982
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/193	93/9376	2.08947573680985	TCF7L2/PARD3/IQGAP1/FGFR1	1.53068865136736
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	7/193	203/9376	1.67518313382169	LAMA3/FN1/LAMB3/ITGB1/LAMB1/FLNB/FLT1	1.40989219960884
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	6/193	170/9376	1.71459920755867	TUBA1C/PARD3/ITGB1/EZR/ARPC2/PRKCE	1.36308678137934
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	3/193	63/9376	2.31334813718233	PLOD2/PIPOX/KMT2C	1.51627277162023
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/193	98/9376	1.98286983187057	CYP11A1/ATF4/GNAS/PRKCE	1.41792695754558
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/193	33/9376	2.94426126550479	SNAP23/VAMP8	1.6219610474115
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/193	65/9376	2.2421681944998	CYP11A1/ATF4/GNAS	1.45683685791761
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/193	138/9376	1.76015619133438	FN1/ITGB1/FOS/ARPC2/WIPF2	1.30414356231564
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/193	103/9376	1.88661401478948	PABPC1/ACIN1/SRRM1/UPF2	1.31164127583224
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	11/193	388/9376	1.37727685486886	TUBA1C/PSMD1/ATF6/PSMC3/PSMC1/SLC39A6/ATF4/MME/NDUFA13/TUBB2A/BACE2	1.1003136342659
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/193	308/9376	1.41955453872552	TUBA1C/AP2B1/GPX7/PSMD1/PSMC3/PSMC1/GPX3/NDUFA13/TUBB2A	1.0853755315028
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/193	112/9376	1.73501110288675	LAMA3/LAMB3/ITGB1/LAMB1	1.13442460664549
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/193	41/9376	2.36977126247946	PIPOX/MAOA	1.27425051657822
NA	NA	hsa04519	Cadherin signaling	11/193	404/9376	1.32273123685426	TCF7L2/YWHAE/LIMA1/DSP/TEAD1/DAAM1/ARPC2/FGFR1/PKP2/PKP3/ATN1	0.961300245092853
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/193	42/9376	2.31334813718233	AOC1/MAOA	1.23663806357145
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/193	78/9376	1.8684734954165	FN1/ITGB1/ARPC2	1.1165575174929
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/193	78/9376	1.8684734954165	ITGB1/FOS/SERPING1	1.1165575174929
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/193	80/9376	1.82176165803109	EIF4E2/FOXO3/RPS6	1.07007646030733
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/193	13/9376	3.736946990833	RAD50	1.43153691317004
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/193	122/9376	1.59279707805997	FOS/ATF4/GNAS/CSH1	0.955417567735102
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	3/193	83/9376	1.7559148511143	USP16/CBX3/USP7	1.00278067516272
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	6/193	205/9376	1.42186275748768	YWHAE/HLA-G/PSMC1/SNW1/ATF4/USP7	0.885343435348647
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/193	250/9376	1.36024870466321	CTSV/AP2B1/BLOC1S6/CD63/SLC17A5/VAMP8/ATP6V1G1	0.836959032343017
Organismal Systems	Immune system	hsa04611	Platelet activation	4/193	126/9376	1.54223209145489	ITGB1/GNAS/SNAP23/VAMP8	0.888324467059982
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/193	89/9376	1.63753856901671	TUBA1C/GNAS/TUBB2A	0.876063818685877
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/193	51/9376	1.90511023062075	GNAS/ATP6V1G1	0.939580818693962
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	3/193	90/9376	1.61934369602763	EIF4E2/FOXO3/ATF4	0.855875583774678
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/193	16/9376	3.03626943005181	MAOA	1.18176006231583
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	12/193	480/9376	1.21450777202073	TUBA1C/GPX7/PSMD1/ATF6/PSMC3/PSMC1/GPX3/ATF4/CHMP2B/ATXN2/NDUFA13/TUBB2A	0.699420350073435
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/193	52/9376	1.8684734954165	CYP11A1/GNAS	0.910393417345777
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/193	133/9376	1.46106198137832	FOS/ATF4/GNAS/MAOA	0.776337664610647
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/193	53/9376	1.83321927852185	AP2B1/GNAS	0.881843266416427
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/193	178/9376	1.36461547418059	TCF7L2/NOTUM/DAAM1/SFRP1/TLE6	0.711984263991081
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/193	94/9376	1.55043545364348	HSP90B1/FOS/MAPK6	0.777537859040223
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/193	95/9376	1.53411508044723	FOS/FLT1/ATP6V1G1	0.758527371707024
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	4/193	139/9376	1.3979945577217	HSP90B1/FOS/ATF4/GNAS	0.68531630133391
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/193	99/9376	1.47213063275239	IL1RAP/GNAS/PRKCE	0.684617503945715
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/193	142/9376	1.3684594614318	HSP90B1/IL1R2/FOS/TXN	0.641373409369443
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	7/193	275/9376	1.23658973151201	TUBA1C/PSMD1/PSMC3/PSMC1/ATF4/NDUFA13/TUBB2A	0.577284213914056
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/193	20/9376	2.42901554404145	UGP2	0.927425098073394
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/193	59/9376	1.64679019935014	GPX7/GPX3	0.722475940698536
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/193	59/9376	1.64679019935014	TCF7L2/FOXO3	0.722475940698536
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/193	232/9376	1.25638735036627	FN1/ITGB1/EZR/IQGAP1/ARPC2/FGFR1	0.573250547859474
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/193	144/9376	1.34945308002303	PSMD1/PSMC3/PSMC1/ATXN2	0.612624302863696
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/193	235/9376	1.24034836291478	RPS6/GNAS/SMARCE1/COX16/FGFR1/NDUFA13	0.54094143100768
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/193	103/9376	1.41496051109211	COL11A1/COL17A1/MME	0.613885326771072
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	4/193	148/9376	1.31298137515754	TCF7L2/FOS/FGFR1/HES1	0.556374939046285
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/193	105/9376	1.3880088823094	TPM1/ITGB1/GNAS	0.579622221597335
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/193	23/9376	2.11218742960126	MME	0.774173735769119
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	3/193	108/9376	1.34945308002303	ACIN1/SRRM1/UPF2	0.529516793681822
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/193	109/9376	1.33707277653658	GATA3/FOS/IL1RAP	0.513144107761549
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/193	24/9376	2.02417962003454	HS6ST1	0.728285229385329
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	3/193	110/9376	1.32491756947715	EIF4E2/RPS6/FLT1	0.496930200087867
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/193	110/9376	1.32491756947715	LTBP1/FBN1/NOG	0.496930200087867
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/193	155/9376	1.25368544208591	TCF7L2/CYP11A1/ATF4/GNAS	0.461683532518444
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/193	157/9376	1.2377149269001	ZFP36L1/HLA-G/RAD50/FOXO3	0.435448072623924
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/193	157/9376	1.2377149269001	TCF7L2/YWHAE/PARD3/TEAD1	0.435448072623924
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/193	158/9376	1.22988128812225	YWHAE/CDKN1C/RAD21/SMC3	0.422460213451377
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/193	250/9376	1.1659274611399	PARD3/AP2B1/HLA-G/ARPC2/WIPF2/CHMP2B	0.385496146182154
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/193	26/9376	1.8684734954165	HES1	0.642849688837815
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	6/193	253/9376	1.15210223432796	ITGB1/UBE2V1/ARPC2/FOXO3/CBX3/PRKCE	0.355548636448991
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/193	70/9376	1.3880088823094	HLA-G/EIF4G1	0.472368755777064
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/193	71/9376	1.3684594614318	FOS/FOXO3	0.45178592751139
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/193	28/9376	1.73501110288675	ATP6V1G1	0.564658101780911
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	5/193	212/9376	1.14576204907616	PARD3/ITGB1/FLT1/GNAS/FGFR1	0.31120162465494
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/193	120/9376	1.21450777202073	YWHAE/FOXO3/ATF4	0.342841970614703
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/193	29/9376	1.67518313382169	TEAD1	0.527905836007739
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	5/193	216/9376	1.12454423335252	HSP90B1/TNFSF10/FOS/ATF6/ATF4	0.268457018712013
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	3/193	122/9376	1.19459780854498	MED4/MED13L/THRB	0.313635427379441
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/193	76/9376	1.27842923370603	EZR/GNAS	0.353306928757139
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/193	78/9376	1.24564899694433	ITGB1/FOS	0.315819925018262
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/193	79/9376	1.22988128812225	AP2B1/ATP6V1G1	0.297452588574521
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/193	32/9376	1.51813471502591	UGP2	0.425621213696174
Human Diseases	Immune disease	hsa05310	Asthma	1/193	32/9376	1.51813471502591	PRG2	0.425621213696174
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	3/193	130/9376	1.1210840972499	FOS/ATF4/GNAS	0.201536559528705
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/193	82/9376	1.18488563123973	PDIA3/HLA-G	0.243770278257211
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/193	133/9376	1.09579648603374	TNFSF10/FOXO3/USP7	0.161302434919948
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/193	134/9376	1.08761890031707	CALD1/GNAS/PRKCE	0.148094597523966
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/193	85/9376	1.14306613837245	ADK/NT5E	0.192082185405408
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	4/193	184/9376	1.05609371480063	PARD3/ITGB1/SEMA5A/SEMA4C	0.111401260857379
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/193	36/9376	1.34945308002303	UGP2	0.304536032499903
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/193	36/9376	1.34945308002303	UGP2	0.304536032499903
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/193	86/9376	1.12977467164719	ATF4/GNAS	0.175268273203386
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/193	37/9376	1.31298137515754	MAOA	0.276529309544251
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/193	37/9376	1.31298137515754	UGP2	0.276529309544251
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/193	37/9376	1.31298137515754	TCF7L2	0.276529309544251
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/193	87/9376	1.11678875588113	TCF7L2/FOS	0.158652959371794
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/193	38/9376	1.27842923370603	UGP2	0.24931688733342
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/193	38/9376	1.27842923370603	NT5E	0.24931688733342
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/193	39/9376	1.24564899694433	HLA-G	0.222851529832619
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/193	93/9376	1.04473786840493	GATA3/FOS	0.0628556884197389
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/193	93/9376	1.04473786840493	ATF4/GNAS	0.0628556884197389
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/193	41/9376	1.18488563123973	RAD50	0.171992665905889
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/193	298/9376	0.978127064714678	IL1R2/TNFSF10/INHA/IL1RAP/CSH1/CSF2RB	-0.0556278290568291
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/193	42/9376	1.15667406859117	SAT1	0.14752304534433
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/193	300/9376	0.97160621761658	IGF2/FOS/IL1RAP/FLT1/ATF4/FGFR1	-0.0724617192073307
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/193	97/9376	1.00165589445008	FOS/GNAS	0.00237651155843816
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/193	201/9376	0.966772355837393	IL1R2/HPGD/FLT1/ARNT2	-0.0690345572262826
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/193	44/9376	1.1040979745643	HLA-G	0.100335184417064
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/193	98/9376	0.991434915935286	ARPC2/PRKCE	-0.0123563295923821
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/193	99/9376	0.98142042183493	FOS/GNAS	-0.0269414936149795
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/193	99/9376	0.98142042183493	TPM1/ITGB1	-0.0269414936149795
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/193	45/9376	1.07956246401842	HLA-G	0.077557247447026
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/193	100/9376	0.97160621761658	IL1R2/MME	-0.0413823243215761
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/193	154/9376	0.946369692483682	TPM1/ATF4/GNAS	-0.0972814620986862
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/193	101/9376	0.961986354075822	TCF7L2/GNAS	-0.0556820548110811
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/193	101/9376	0.961986354075822	FN1/PRKCE	-0.0556820548110811
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/193	47/9376	1.03362363576232	GLO1	0.0335002505669716
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/193	47/9376	1.03362363576232	PRKCE	0.0335002505669716
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	2/193	103/9376	0.943307007394738	FOS/GNAS	-0.0838706222900955
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	3/193	157/9376	0.928286195175077	FOS/ATF4/NDUFA13	-0.131365911677327
NA	NA	hsa03272	Virion - Hepatitis viruses	1/193	48/9376	1.01208981001727	CD63	0.0121735663408275
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/193	158/9376	0.92241096609169	EIF4E2/RPS6/ATP6V1G1	-0.14258785521055
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/193	107/9376	0.908043194034187	ATF4/GNAS	-0.138685586138582
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/193	217/9376	0.895489601489936	HSP90B1/FOS/ATF4/GNAS	-0.225806969231682
NA	NA	hsa04081	Hormone signaling	4/193	219/9376	0.887311614261717	IGF2/GNAS/CSH1/THRB	-0.244622617306554
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/193	54/9376	0.899635386682019	AMD1	-0.107224726428165
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/193	54/9376	0.899635386682019	HES1	-0.107224726428165
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/193	54/9376	0.899635386682019	HLA-G	-0.107224726428165
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	4/193	224/9376	0.867505551443375	IL1R2/FOS/HLA-G/ATF4	-0.290961606501283
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/193	55/9376	0.883278379651437	UGCG	-0.125855847698621
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	3/193	170/9376	0.857299603779336	IGF2/TCF7L2/SMARCE1	-0.272198767824707
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/193	56/9376	0.867505551443375	SCUBE2	-0.144163640171792
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/193	115/9376	0.844874971840505	FOS/ATF4	-0.242646399795361
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	2/193	115/9376	0.844874971840505	GNAS/MAOA	-0.242646399795361
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	4/193	227/9376	0.856040720367031	PDIA3/HLA-G/ATF4/GNAS	-0.318300836632716
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/193	116/9376	0.837591566910845	ITGB1/EZR	-0.255154997048481
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/193	116/9376	0.837591566910845	SLC38A1/GNAS	-0.255154997048481
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/193	119/9376	0.816475813123177	FOS/ATF4	-0.292081236126488
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/193	59/9376	0.823395099675068	NT5E	-0.197270755837713
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/193	59/9376	0.823395099675068	GNAS	-0.197270755837713
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/193	60/9376	0.809671848013817	GNAS	-0.21440549741624
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/193	61/9376	0.796398539029984	STEAP1	-0.231273769230517
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/193	62/9376	0.783553401303694	FOXO3	-0.247885140699847
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/193	63/9376	0.771116045727445	HPGD	-0.264248677025431
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/193	63/9376	0.771116045727445	CETN2	-0.264248677025431
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/193	63/9376	0.771116045727445	TCF7L2	-0.264248677025431
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/193	183/9376	0.796398539029984	GNL3/SBDS/REXO2	-0.403227186327724
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/193	128/9376	0.759067357512953	ADK/NT5E	-0.397876893745087
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/193	66/9376	0.736065316376197	CYP11A1	-0.311936067190817
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/193	66/9376	0.736065316376197	GATA3	-0.311936067190817
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/193	67/9376	0.725079266878045	ATF4	-0.327389977519028
Human Diseases	Substance dependence	hsa05034	Alcoholism	3/193	191/9376	0.763041532159618	ATF4/GNAS/MAOA	-0.479646563127489
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/193	68/9376	0.71441633648278	TCF7L2	-0.342634926016909
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/193	69/9376	0.704062476533754	GNAS	-0.357677584602281
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	2/193	133/9376	0.730530990689158	TNFSF10/HLA-G	-0.453732794770752
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/193	70/9376	0.6940044411547	ARNT2	-0.372524310641431
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/193	71/9376	0.684229730715902	ATP6V1G1	-0.387181166239213
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/193	71/9376	0.684229730715902	FGFR1	-0.387181166239213
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	3/193	196/9376	0.743576186951465	TCF7L2/FOS/HLA-G	-0.525941026331278
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/193	138/9376	0.704062476533754	NDUFA13/ATP6V1G1	-0.507718045943489
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/193	138/9376	0.704062476533754	YWHAE/SMC3	-0.507718045943489
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/193	138/9376	0.704062476533754	EIF4E2/RPS6	-0.507718045943489
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/193	73/9376	0.665483710696288	MAOA	-0.415948143984328
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/193	73/9376	0.665483710696288	SUPT5H	-0.415948143984328
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/193	73/9376	0.665483710696288	FGFR1	-0.415948143984328
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/193	73/9376	0.665483710696288	FOXO3	-0.415948143984328
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/193	140/9376	0.6940044411547	RPS6/PRKCE	-0.528821592330812
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	2/193	144/9376	0.674726540011514	TCF7L2/FOXO3	-0.570235141874775
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/193	78/9376	0.622824498472167	IMPA2	-0.484917667456379
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/193	78/9376	0.622824498472167	PABPC1	-0.484917667456379
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/193	214/9376	0.68103239552564	PDIA3/FOS/HLA-G	-0.684274443685735
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/193	83/9376	0.585304950371434	PIPOX	-0.550125693707653
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/193	154/9376	0.630913128322455	FOS/GNAS	-0.669496636902501
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/193	87/9376	0.558394377940563	TPM1	-0.599903974371165
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/193	89/9376	0.545846189672236	SLC38A1	-0.624068473159394
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	2/193	160/9376	0.607253886010363	ITGB1/HLA-G	-0.726394681066292
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/193	90/9376	0.539781232009211	GNAS	-0.63597968178981
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/193	90/9376	0.539781232009211	FOS	-0.63597968178981
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/193	91/9376	0.533849570119	FOS	-0.647780442325512
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/193	91/9376	0.533849570119	GNAS	-0.647780442325512
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	3/193	227/9376	0.642030540275273	FOS/FOXO3/NDUFA13	-0.791487556827474
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	2/193	163/9376	0.596077434120601	FOS/ATF4	-0.75415980829333
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/193	93/9376	0.522368934202463	GNAS	-0.671060793054074
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/193	166/9376	0.585304950371434	ATF4/PRKCE	-0.781492978803393
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/193	168/9376	0.578337034295583	TNFSF10/CHMP2B	-0.799483389569606
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/193	168/9376	0.578337034295583	CSH1/CSF2RB	-0.799483389569606
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/193	169/9376	0.574914921666616	TAX1BP1/VAMP8	-0.808410864611041
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/193	98/9376	0.495717457967643	IMPA2	-0.727497973161365
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	3/193	238/9376	0.612356859842383	IGF2/FLT1/FGFR1	-0.87814656161986
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/193	99/9376	0.490710210917465	FOS	-0.738500491175674
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/193	100/9376	0.48580310880829	TNFSF10	-0.74941274921044
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/193	102/9376	0.476277557655186	GNAS	-0.770973987262802
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/193	180/9376	0.539781232009211	PDIA3/HLA-G	-0.903801582202371
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/193	109/9376	0.445690925512193	FOS	-0.843854666564296
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/193	109/9376	0.445690925512193	PRKCE	-0.843854666564296
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/193	254/9376	0.57378319937987	FLT1/GNAS/FGFR1	-0.998330615387672
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	2/193	187/9376	0.519575517442021	YWHAE/TXN	-0.962019353560093
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/193	323/9376	0.60161375703813	TPM1/EZR/SOX4/PRKCE	-1.05628553988596
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/193	193/9376	0.503422910682166	PARD3/FOXO3	-1.0105202979091
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/193	122/9376	0.398199269514992	FOXO3	-0.969928853331881
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/193	122/9376	0.398199269514992	FOS	-0.969928853331881
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/193	125/9376	0.388642487046632	PRKCE	-0.997534489359145
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/193	136/9376	0.35720816824139	FOS	-1.09465135371247
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/193	142/9376	0.342114865357951	UBE2K	-1.14517355624194
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/193	142/9376	0.342114865357951	FOS	-1.14517355624194
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/193	226/9376	0.429914255582558	FOS/GNAS	-1.25763858779595
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/193	144/9376	0.337363270005757	FGFR1	-1.16166486424401
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/193	149/9376	0.326042354904893	GNAS	-1.20217440841094
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/193	149/9376	0.326042354904893	NDUFA13	-1.20217440841094
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/193	150/9376	0.323868739205527	TCF7L2	-1.21015756729894
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/193	154/9376	0.315456564161227	UGP2	-1.24171181170632
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/193	156/9376	0.311412249236083	YWHAE	-1.257268781569
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/193	157/9376	0.309428731725026	STAB2	-1.26499388027983
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	1/193	173/9376	0.280811045553925	TNFSF10	-1.3841187434978
NA	NA	hsa04082	Neuroactive ligand signaling	1/193	199/9376	0.244122165230297	GNAS	-1.56242717249257
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/193	205/9376	0.236977126247946	NDUFA13	-1.60132005091009
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/193	370/9376	0.262596275031508	CSH1/THRB	-2.09803253346428