category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	29/479	174/9376	3.26235212247738	HSP90B1/PDIA3/ERLEC1/SIL1/CKAP4/RPN2/SEC62/SEC63/MAN1A2/LMAN1/RRBP1/ATF4/WFS1/PRKCSH/ATF6/UBXN4/HSPA5/DNAJC10/SEC31A/TMEM258/HYOU1/PDIA4/GANAB/UGGT2/NPLOC4/SEC24D/EDEM3/BCAP31/HSP90AA1	6.98916527769921
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	19/479	117/9376	3.17870206805489	RSF1/SMARCA1/MORF4L1/BPTF/BRD7/SMARCE1/ZNHIT1/SMARCC1/MBD2/BAZ1B/CHD3/MORF4L2/CHD4/EPC1/BAZ2B/INO80B/ARID1A/SS18L1/NFRKB	5.50225019009926
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	15/479	93/9376	3.15711495723618	TCF7L2/IQGAP1/PARD3/FGFR1/ARHGAP29/ROCK2/PTPRF/INSR/ACTN4/EGFR/VCL/YES1/HEG1/WASL/LMO7	4.85067512760305
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	26/479	233/9376	2.18423575582177	TPM1/FN1/DSP/COL11A1/TNNI2/PDLIM5/DAAM1/NID2/DSG2/ITGB1/FBN1/MYH10/PKP2/ITGA5/FMNL2/COL27A1/COL4A2/COL4A1/TMOD3/DAG1/DIAPH2/CSRP2/VCL/TPM2/ITGA6/SDC4	4.24720643089782
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	23/479	203/9376	2.21775661528019	LAMA3/FN1/LAMB1/FLNB/ITGB1/XIAP/ITGA5/LAMC1/LAMB3/ROCK2/COL4A2/PPP1R12A/CAV1/COL4A1/PXN/ACTN4/FLT1/EGFR/VCL/PTK2/DOCK1/CRK/ITGA6	4.06990638042657
Genetic Information Processing	Transcription	hsa03040	Spliceosome	25/479	243/9376	2.01379760646752	RBM25/SYF2/ACIN1/CDC5L/SF3B2/SNW1/DDX46/PRPF40A/HNRNPM/U2SURP/SNRPB2/CWC15/RBMX/SLU7/FUS/PRPF38B/RBM8A/SF3B1/SNRNP27/XAB2/HNRNPK/SNRPG/ZMAT2/PRPF6/LSM3	3.71517494443149
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/479	103/9376	2.66055901250583	IL1R2/LAMA3/FN1/LAMB1/GNAQ/LAMC1/LAMB3/GNAS/COL4A2/COL4A1/ACTN4/VCL/PTK2/GNA11	3.93182695897718
NA	NA	hsa04518	Integrin signaling	18/479	154/9376	2.28788330667245	LAMA3/FN1/LAMB1/FLNB/ITGB1/FBN1/ITGA5/LAMC1/LAMB3/COL4A2/COL4A1/PXN/ACTN4/FLT1/EGFR/VCL/PTK2/ITGA6	3.73900387360227
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/479	62/9376	3.15711495723618	CIR1/SPEN/SNW1/HES1/TLE6/CTBP2/NCOR2/ITCH/DTX4/PSEN1	3.95396315267049
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	10/479	63/9376	3.10700202140703	PLOD2/KMT2C/KMT2E/PIPOX/HADHA/COLGALT1/ASH1L/PLOD3/KMT2A/PRDM2	3.89333725160073
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/479	89/9376	2.63920621144238	LAMA3/FN1/LAMB1/ITGB1/ITGA5/LAMC1/LAMB3/COL4A2/COL4A1/DAG1/ITGA6/SDC4	3.60514279504744
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	11/479	78/9376	2.7604517959424	FN1/ITGB1/ITGA5/CAV1/PXN/CTTN/VCL/PTK2/DOCK1/CRK/WASL	3.62249894714548
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/479	93/9376	2.52569196578894	LAMA3/FN1/LAMB1/ITGB1/XIAP/LAMC1/LAMB3/COL4A2/COL4A1/PTK2/RXRA/ITGA6	3.43080281651672
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	29/479	333/9376	1.70465246039359	LAMA3/TCF7L2/FN1/LAMB1/PARD3/CREB5/HLA-G/ITGB1/PSMC1/ITGA5/LAMC1/LAMB3/GNAS/HES1/COL4A2/COL4A1/PXN/IFNAR1/PPP2R2A/EGFR/CHD4/PTK2/IRF3/WNT7A/TSC1/ITGA6/BCAP31/PSEN1/CSNK1A1	3.03789265341161
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/479	31/9376	3.78853794868341	SEC62/SEC63/SRP14/SPCS2/HSPA5/SRP72	3.60827270240379
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/479	75/9376	2.60988169798191	HSP90B1/CREB5/GPX3/GPX7/GNAQ/GNAS/ATF4/GPX8/HSPA5/PDIA4	3.2478156654202
NA	NA	hsa04519	Cadherin signaling	33/479	404/9376	1.59887554517456	TCF7L2/DSP/TEAD1/LIMA1/DAAM1/YWHAE/DSG2/PKP2/FGFR1/FMN1/PKP3/ROCK2/LIMD1/STK3/ACTN4/AMOTL2/MYO1C/TAOK3/EGFR/GJA1/VCL/SHOC2/PTK2/FAT1/WWTR1/EVL/ANKRD6/WNT7A/NCKAP1/ATN1/ADAM10/PSEN1/CSNK1A1	2.855053356471
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	13/479	115/9376	2.21272578741944	GATA3/CREB5/MMP15/FGFR1/GNAQ/GNAS/ATF4/FOS/EGR1/PTH1R/EGFR/RXRA/GNA11	3.03608684598345
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	30/479	362/9376	1.62216403880091	IGF2/HSP90B1/LAMA3/FN1/LAMB1/FOXO3/EIF4E2/YWHAE/CREB5/ITGB1/FGFR1/ITGA5/LAMC1/LAMB3/PKN2/ATF4/COL4A2/COL4A1/CSH1/IFNAR1/INSR/EIF4B/PPP2R2A/FLT1/EGFR/PTK2/RXRA/TSC1/ITGA6/HSP90AA1	2.80112192731171
NA	NA	hsa04382	Cornified envelope formation	20/479	217/9376	1.80406568984924	LAMA3/DSP/COL17A1/UGCG/PADI1/DSG2/S100A13/PKP2/LAMB3/PKP3/COL4A2/COL4A1/PCSK6/PPP2R2A/PRSS8/KDSR/DST/S100A6/ITGA6/CLDN19	2.78053885241338
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/479	204/9376	1.82307912726677	IGF2/FN1/IQGAP1/EZR/ITGB1/FGFR1/ITGA5/ROCK2/PPP1R12A/CAV1/PXN/EIF4B/EGFR/PDCD4/CTTN/PTK2/WNT7A/MMP2/SDC4	2.7577586071129
NA	NA	hsa04517	IgSF CAM signaling	25/479	299/9376	1.63663149957059	IQGAP1/TRIO/PARD3/EZR/ITGB1/TUBA1C/MYH10/FGFR1/ITGA5/SRGAP2/IL1RAP/TUBB2A/JAM2/PTPRF/PXN/TJP2/PTPRS/ACTN4/ERC1/DYNLL1/VCL/PTK2/WASL/LMO7/MYL6B	2.59587723074459
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	14/479	138/9376	1.98577955281232	FN1/ITGB1/ITGA5/GNAQ/PKN2/ROCK2/FOS/PXN/WIPF2/PTK2/IRF3/DOCK1/CRK/WASL	2.70683616055515
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/479	49/9376	2.79630181926633	GALNT1/GALNT7/GALNT6/COLGALT1/PLOD3/GALNT3/FUT11	2.92508143192822
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/479	29/9376	3.37484702325247	TEAD1/LIMD1/STK3/CSNK1E/WWTR1	2.97187211372442
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	20/479	232/9376	1.68742351162623	FN1/IQGAP1/EZR/ITGB1/MYH10/FGFR1/ITGA5/ROCK2/PPP1R12A/PXN/ACTN4/DIAPH2/EGFR/VCL/PTK2/DOCK1/CRK/NCKAP1/WASL/ITGA6	2.45998163790714
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	21/479	253/9376	1.62472872502826	FOXO3/ITGB1/UBE2V1/ITGA5/ROCK2/CBX3/TECPR1/PXN/ATG12/ACTN4/FNBP1L/EGFR/CTTN/VCL/PTK2/IRF3/DOCK1/CRK/CALCOCO2/WASL/CAST	2.33730020976683
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/479	56/9376	2.44676409185804	RPN2/MAN1A2/MAN2A1/ALG11/MGAT5/TMEM258/GANAB	2.51950589102773
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/479	200/9376	1.66379958246347	EZR/ITGB1/TUBA1C/MYH10/TNFSF10/ROCK2/FOS/TUBB2A/MYO6/WIPF2/MYO1C/NCL/CTTN/NCKAP1/WASL/SEC24D/CLDN19	2.20169354887169
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	15/479	170/9376	1.72712759425273	PARD3/EZR/ITGB1/TUBA1C/MYH10/ROCK2/JAM2/TJP2/ACTN4/AMOTL2/PPP2R2A/RAB8B/CTTN/CLDN19/MYL6B	2.21988870424291
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	20/479	248/9376	1.57855747861809	HSP90B1/TCF7L2/DYNC1I2/TUBA1C/AHNAK/DYNC1LI2/TNFSF10/GCC2/ROCK2/FOS/TUBB2A/KIF5B/MYO6/DYNLL1/TXN/NCKAP1/WASL/ANXA2/DYNLT1/HSP90AA1	2.14247684091306
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	9/479	86/9376	2.04845365829975	TCF7L2/DSP/DSG2/ITGB1/PKP2/ITGA5/DAG1/GJA1/ITGA6	2.26632509440918
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/479	116/9376	1.85616586278886	EZR/ITGB1/CD99/ROCK2/JAM2/PXN/ACTN4/VCL/PTK2/MMP2/CLDN19	2.152846218173
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	10/479	103/9376	1.90039929464702	ACIN1/SRRM1/PABPC4/PABPC1/PNN/UPF2/PPP2R2A/FUS/RBM8A/SMG1	2.13194122814998
Cellular Processes	Cell motility	hsa04814	Motor proteins	16/479	194/9376	1.61435981318468	TPM1/TNNI2/KIF21A/DYNC1I2/TUBA1C/MYH10/DYNC1LI2/TUBB2A/KIF5B/MYO6/MYO1C/DYNLL1/KIF3A/TPM2/DYNLT1/MYL6B	2.00625725404601
Genetic Information Processing	Translation	hsa03010	Ribosome	17/479	222/9376	1.49891854275988	RPS26/RPS4Y1/RPL6/RPL34/RPL4/MRPS35/RPS16/RPL22/RPL14/RPL5/MRPL52/RSL24D1/MRPL33/RPL12/RPS12/MRPL1/MRPL21	1.74554993816149
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/479	44/9376	2.22433099259822	RPN2/MAN1A2/MAN2A1/ALG11/TMEM258	1.88872798884162
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	5/479	44/9376	2.22433099259822	CREB5/DYNC1I2/DYNC1LI2/GNAS/DYNLL1	1.88872798884162
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/479	46/9376	2.12762094944177	PSMD1/PSMC1/PSMC3/PSME4/PSME1	1.7788233816711
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	19/479	268/9376	1.38771694762098	PSMD1/TUBA1C/PSMC1/PSMC3/GNAS/ATF4/TUBB2A/ATF6/KIF5B/MAOA/SLC39A6/HSPA5/NDUFA13/NDUFS1/DAXX/TXN/UBE2L3/UBA1/NDUFS6	1.49417776957757
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	4/479	34/9376	2.30283679233698	POLR2J3/CRCP/POLR2F/POLR2L	1.76579849074707
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	17/479	238/9376	1.39815090963316	RPS26/RPS4Y1/RPL6/C1S/RPL34/RPL4/RPS16/FOS/RPL22/RPL14/IFNAR1/RPL5/EGFR/RSL24D1/IRF3/RPL12/RPS12	1.4435845107721
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/479	157/9376	1.49611052750555	TCF7L2/TEAD1/PARD3/YWHAE/DLG5/BMPR2/LIMD1/STK3/PPP2R2A/CSNK1E/WWTR1/WNT7A	1.45451418574234
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	21/479	308/9376	1.33459859555893	CREB5/PSMD1/RB1CC1/AP2B1/TUBA1C/PSMC1/GPX3/GPX7/PSMC3/GNAQ/TUBB2A/KIF5B/GPX8/POLR2J3/NDUFA13/NDUFS1/REST/HIP1/POLR2F/POLR2L/NDUFS6	1.38540042290405
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/479	36/9376	2.17490141498492	GALNT1/GALNT7/GALNT6/GALNT3	1.63874295905834
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/479	50/9376	1.95741127348643	SAT1/P4HA1/AMD1/AOC1/MAOA	1.57495240227822
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/479	65/9376	1.80684117552594	CREB5/GNAQ/GNAS/ATF4/CYP11A1/GNA11	1.5145310035275
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/479	178/9376	1.42957003119795	TCF7L2/NOTUM/DAAM1/SFRP1/TLE6/ROCK2/CTBP2/TBL1XR1/CSNK1E/ANKRD6/WNT7A/PSEN1/CSNK1A1	1.34254506807266
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	8/479	98/9376	1.59788675386647	CREB5/GNAQ/GNAS/ATF4/DAGLB/PRKD3/CYP11A1/GNA11	1.38049991789248
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/479	13/9376	3.01140195920989	RAD50/XRCC4	1.68381600362332
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	14/479	201/9376	1.36337103625921	IL1R2/ARNT2/HPGD/NUPR1/AFF1/FUS/FLT1/PTK2/JMJD1C/RXRA/NCOR1/KMT2A/SS18L1/CEBPB	1.20830590887865
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/479	56/9376	1.74768863704146	SCUBE2/KIF3A/CSNK1E/GLI3/CSNK1A1	1.30208230649485
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/479	105/9376	1.49136097027538	TOMM20/FOXO3/TAX1BP1/TBC1D15/ATF4/USP8/OPTN/CALCOCO2	1.17479912749616
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	11/479	155/9376	1.38913058118392	TCF7L2/CREB5/GNAQ/GNAS/ATF4/USP8/EGFR/CYP11A1/KMT2A/WNT7A/GNA11	1.13345374146161
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	7/479	89/9376	1.53953695667472	TUBA1C/GNAQ/GNAS/TUBB2A/EGFR/GJA1/GNA11	1.18661566704664
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/479	122/9376	1.44399192306376	CREB5/GNAQ/GNAS/ATF4/FOS/CSH1/PTK2/CRK/GNA11	1.14530679416971
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/479	139/9376	1.40820954927081	HSP90B1/CREB5/GNAQ/GNAS/ATF4/FOS/NCOA1/EGFR/MMP2/HSP90AA1	1.12501079031272
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/479	106/9376	1.47729152715957	HSP90B1/IL1R2/TCF7L2/CREB5/FGFR1/ATF4/EGFR/HSP90AA1	1.14664343810673
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	7/479	90/9376	1.52243099048945	FOXO3/EIF4E2/CREB5/RB1CC1/ATF4/INSR/TSC1	1.15549333817007
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/479	157/9376	1.37143465021342	STAB2/SLC2A1/ABCA1/PTK2/RXRA/ADAM9/DOCK1/CRK/ANO6/ADAM10/CEBPB	1.08898509073791
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	23/479	368/9376	1.22338204592902	PSMD1/RB1CC1/TUBA1C/PSMC1/GPX3/GPX7/PSMC3/ATF4/TUBB2A/ATF6/KIF5B/MATR3/GPX8/HSPA5/NDUFA13/FUS/CHMP2B/NDUFS1/TPR/DAXX/OPTN/ATXN2/NDUFS6	1.01435408954579
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	15/479	227/9376	1.29344357278839	PDIA3/CREB5/HLA-G/GNAQ/GNAS/ROCK2/ATF4/PXN/EGFR/PTK2/IRF3/TAPBP/CRK/TSC1/GNA11	1.03844217025993
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/479	108/9376	1.44993427665661	ACIN1/SRRM1/PNN/UPF2/KPNA6/TPR/RBM8A/SNUPN	1.09118790730428
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	10/479	142/9376	1.3784586433003	UBE2K/XIAP/MID1/ITCH/CUL5/UBE2H/ANAPC7/UBE2Q1/UBE2L3/UBA1	1.05438511166141
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/479	142/9376	1.3784586433003	HSP90B1/IL1R2/BMPR2/CAV1/FOS/TXN/PTK2/MMP2/SDC4/HSP90AA1	1.05438511166141
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	29/479	480/9376	1.18260264439805	PSMD1/RB1CC1/TUBA1C/PSMC1/GPX3/GPX7/PSMC3/GNAQ/ATF4/TUBB2A/ATF6/KIF5B/GPX8/HSPA5/NDUFA13/FUS/CHMP2B/NDUFS1/CSNK1E/DAXX/UBE2L3/UBA1/OPTN/ATXN2/HIP1/WNT7A/PSEN1/NDUFS6/CSNK1A1	0.952931962066587
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/479	93/9376	1.47332031337688	GNAQ/GNAS/ATF4/EGR1/EGFR/MMP2/GNA11	1.06434896470617
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/479	78/9376	1.50570097960495	PABPC4/PABPC1/ZCCHC7/DHX36/XRN2/LSM3	1.04058587142893
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/479	78/9376	1.50570097960495	C1S/ITGB1/ITGA5/FOS/SERPING1/IRF3	1.04058587142893
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/479	17/9376	2.30283679233698	MYH10/DAG1	1.24747356488242
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/479	63/9376	1.55350101070352	RFC1/CETN2/POLR2J3/POLR2F/POLR2L	1.02276413685241
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/479	183/9376	1.28354837605668	GNL3/SBDS/UTP14C/NOP58/XRN2/UTP14A/BMS1/MPHOSPH10/REXO2/RBM28/GNL2/TCOF1	0.898784716430171
NA	NA	hsa03272	Virion - Hepatitis viruses	4/479	48/9376	1.63117606123869	VPS4B/EGFR/TGOLN2/CLDN19	1.01720495848722
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	12/479	184/9376	1.27657256966506	SEMA4C/PARD3/SEMA5A/ITGB1/SRGAP2/ROCK2/BMPR2/EPHB2/PTK2/EPHB3/ABLIM1/SEMA7A	0.879112809295227
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	9/479	133/9376	1.32456401965247	CREB5/GNAQ/GNAS/ATF4/FOS/KIF5B/MAOA/PPP2R2A/CLOCK	0.874684271115713
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	4/479	49/9376	1.59788675386647	CREB5/GNAS/ATF4/MAOA	0.973593314538286
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/479	82/9376	1.43225215133153	PDIA3/HLA-G/HSPA5/TAPBP/PSME1/HSP90AA1	0.912166997328113
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/479	99/9376	1.38402817317222	GNAS/FOS/CARM1/EGFR/PTK2/NCOR1/MMP2	0.891268392066645
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/479	205/9376	1.24128519782066	PDIA3/CIR1/HLA-G/PSMD1/USP7/PSMC1/SNW1/PSMC3/HES1/IFNAR1/NCOR2/IRF3/TAPBP	0.810458652907374
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/479	34/9376	1.72712759425273	NFIL3/CLOCK/CSNK1E	0.985511628213158
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/479	20/9376	1.95741127348643	UGP2/GNE	0.994489100964607
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/479	138/9376	1.27657256966506	EIF4E2/PTPRF/INSR/INPP5A/PPP1R3D/PHKA2/CRK/TSC1/PPP1R3B	0.759436154311857
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	6/479	86/9376	1.36563577219983	CREB5/GNAQ/SLC2A1/GNAS/ATF4/GNA11	0.79035398407018
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/479	69/9376	1.41841396629451	CREB5/GNAS/ATF4/FOS/MAOA	0.809389303206218
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/479	53/9376	1.47729152715957	AP2B1/GNAQ/GNAS/PTH1R	0.808491423367175
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/479	70/9376	1.39815090963316	HLA-G/EIF4G1/CAV1/DAG1/CD55	0.77579469910794
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	7/479	105/9376	1.30494084899095	TPM1/ITGB1/ITGA5/GNAS/DAG1/TPM2/ITGA6	0.729085672253817
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/479	37/9376	1.58709022174575	UGP2/GNE/GFPT1	0.830208395776538
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/479	37/9376	1.58709022174575	TCF7L2/TPR/RXRA	0.830208395776538
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/479	88/9376	1.33459859555893	CLU/SERPINE2/C1S/TFPI/SERPING1/CD55	0.731704870821179
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	15/479	250/9376	1.17444676409186	PARD3/HLA-G/AP2B1/IQSEC1/CAV1/USP8/KIF5B/WIPF2/VPS4B/ITCH/CHMP2B/EGFR/VPS36/RAB11FIP5/WASL	0.648670712005643
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/479	160/9376	1.22338204592902	HLA-G/ITGB1/CD99/JAM2/PTPRF/PTPRS/CD276/ITGA6/SDC4/CLDN19	0.661254472056858
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	3/479	38/9376	1.54532468959455	UGP2/GNE/GFPT1	0.781540743963456
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/479	22/9376	1.77946479407857	AOC1/MAOA	0.849260180213833
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	7/479	109/9376	1.2570531114133	CREB5/SLC2A1/PTPRF/INSR/GFPT1/PPP1R3D/PPP1R3B	0.626322670924682
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/479	23/9376	1.70209675955342	MME/LNPEP	0.782198572546926
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/479	110/9376	1.245625355855	LTBP1/FBN1/BMPR2/SKIL/NOG/NCOR1/FST	0.601249864049176
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/479	130/9376	1.20456078368396	CREB5/GNAS/ATF4/COL4A2/COL4A1/FOS/EGFR/MMP2	0.544940028415054
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/479	112/9376	1.22338204592902	LAMA3/LAMB1/ITGB1/XIAP/LAMC1/LAMB3/ITGA6	0.551810045055033
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/479	24/9376	1.63117606123869	EXTL3/HS6ST1	0.718348998018765
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/479	205/9376	1.14580172106523	YWHAE/CREB5/HLA-G/USP7/PSMC1/SNW1/ATF4/PXN/ACTN4/CHD4/IRF3/HNRNPK	0.489736906836402
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/479	42/9376	1.39815090963316	AOC1/HADHA/MAOA	0.600025985376661
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	10/479	170/9376	1.15141839616849	IGF2/TCF7L2/BRD7/SMARCE1/SMARCC1/EGFR/TXNRD2/WNT7A/ARID1A/CSNK1A1	0.462273732871392
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/479	133/9376	1.17739023969109	FOXO3/USP7/TNFSF10/INSR/ATG12/EGFR/PLK3/CSNK1E	0.478058081340556
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/479	134/9376	1.16860374536503	CALD1/MYH10/GNAQ/GNAS/ROCK2/PPP1R12A/GNA11/MYL6B	0.456108572191829
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/479	44/9376	1.33459859555893	TAF3/TAF5L/TAF13	0.516172290238378
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/479	99/9376	1.18630986271905	TPM1/ITGB1/ITGA5/DAG1/TPM2/ITGA6	0.432395598479425
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	8/479	137/9376	1.14301388232784	CTSV/CSF2RB/XIAP/TUBA1C/TNFSF10/ATF4/FOS/DAXX	0.391252923818424
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	7/479	119/9376	1.15141839616849	CREB5/XIAP/ATF4/FOS/DNM1L/ITCH/CEBPB	0.385699068724504
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/479	120/9376	1.14182324286708	FOXO3/YWHAE/ATF4/MAGED1/KIDINS220/CRK/PSEN1	0.362792216720095
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	9/479	158/9376	1.1149811051505	CDKN1C/RAD21/YWHAE/SMC3/ATRX/PDS5A/ANAPC7/ORC2/STAG2	0.338195846671131
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/479	83/9376	1.17916341776291	USP16/MTF2/USP7/CBX3/JARID2	0.380401320448199
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	21/479	388/9376	1.05942362740245	PSMD1/RB1CC1/TUBA1C/MME/PSMC1/PSMC3/GNAQ/ATF4/TUBB2A/ATF6/KIF5B/INSR/SLC39A6/NDUFA13/NDUFS1/CSNK1E/WNT7A/ADAM10/PSEN1/NDUFS6/CSNK1A1	0.277379965308422
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	12/479	216/9376	1.08745070749246	HSP90B1/TNFSF10/ROCK2/ATF4/FOS/ABCA1/ATF6/HSPA5/PTK2/RXRA/IRF3/HSP90AA1	0.301699135488448
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/479	103/9376	1.14023957678821	COL11A1/COL17A1/MME/COL27A1/COL4A2/COL4A1	0.332055497322776
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/479	122/9376	1.12310482904959	MED13L/SLC2A1/THRB/MED4/NCOA1/RXRA/NCOR1	0.317557121608608
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	15/479	275/9376	1.06767887644714	CREB5/PSMD1/TUBA1C/PSMC1/PSMC3/LAMC1/ATF4/CAV1/TUBB2A/EGR1/KIF5B/HSPA5/NDUFA13/NDUFS1/NDUFS6	0.26430570025621
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/479	12/9376	1.63117606123869	VKORC1	0.507623873887353
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/479	107/9376	1.09761379821669	CREB5/GNAQ/SLC2A1/GNAS/ATF4/PHKA2	0.235623313565022
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/479	70/9376	1.11852072770653	ARNT2/SLC2A1/EPAS1/CRK	0.230936938895502
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/479	148/9376	1.0580601478305	TCF7L2/FGFR1/HES1/FOS/NCOA1/EGFR/WNT7A/CSNK1A1	0.165191159543978
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/479	51/9376	1.15141839616849	GNAS/TJP2/PDIA4	0.251576985681384
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	10/479	187/9376	1.04674399651681	YWHAE/XIAP/PKN2/IFNAR1/ATG12/DNM1L/TXN/IRF3/SUGT1/HSP90AA1	0.149811143187351
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/479	32/9376	1.22338204592902	HADHA/SUCLG1	0.293689512364902
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/479	110/9376	1.06767887644714	EIF4E2/SLC2A1/INSR/FLT1/EGFR/EPAS1	0.165666590573278
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/479	52/9376	1.12927573470371	GNAS/INSR/CYP11A1	0.216894806806099
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/479	33/9376	1.18630986271905	STX16/SNAP23	0.248760396845623
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/479	73/9376	1.07255412245832	FOXO3/KIF5B/EGFR/RXRA	0.144392159907364
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/479	212/9376	1.0156379249222	PARD3/ITGB1/FGFR1/GNAQ/GNAS/INSR/FLT1/EGFR/PRKD3/EVL/CRK	0.0534362672945095
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/479	94/9376	1.04117620930129	HSP90B1/MAPK6/FOS/CEBPB/HSP90AA1	0.0930938748155554
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	11/479	214/9376	1.00614598169863	PDIA3/HLA-G/GNAQ/FOS/PXN/CUL5/PTK2/IRF3/TAPBP/CRK/GNA11	0.0211025338347029
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/479	55/9376	1.06767887644714	UGCG/ASAH1/KDSR	0.116797845222906
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/479	76/9376	1.0302164597297	ACSL4/PLIN2/RXRA/ANGPTL4	0.0613677924531139
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/479	157/9376	0.997407018337034	ATF4/FOS/INSR/NDUFA13/ITCH/NDUFS1/RXRA/NDUFS6	-0.00760219427536943
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	11/479	217/9376	0.992236129417084	HSP90B1/CREB5/XIAP/GNAS/ATF4/FOS/KPNA6/KLF5/EGFR/RXRA/HSP90AA1	-0.0268482340105244
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/479	16/9376	1.22338204592902	MAOA	0.20749227424421
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/479	37/9376	1.0580601478305	GNAQ/APOL1	0.0821032618216298
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	15/479	300/9376	0.978705636743215	IGF2/FGFR1/RASGRF2/ATF4/IL1RAP/FOS/STK3/INSR/TAOK3/FLT1/EGFR/DAXX/CRK/STMN1/MAPK8IP3	-0.0869780449788236
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	5/479	99/9376	0.988591552265874	FOS/CHKB/EGFR/DGKZ/TSC1	-0.0264771951077949
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/479	180/9376	0.978705636743215	PDIA3/HLA-G/ITGA5/IFNAR1/SRPK1/DAXX/IRF3/TAPBP/TSC1	-0.066931880843414
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/479	100/9376	0.978705636743215	IL1R2/MME/ITGA5/ITGA6/CD55	-0.0496724850796278
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/479	59/9376	0.995293867874456	GPX3/GPX7/GPX8	-0.00841363511754448
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/479	59/9376	0.995293867874456	TCF7L2/FOXO3/EGFR	-0.00841363511754448
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/479	17/9376	1.15141839616849	TXNRD2	0.144983966962015
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/479	101/9376	0.969015481923975	FN1/COL4A2/COL4A1/EGR1/MMP2	-0.0726407087682611
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/479	122/9376	0.962661282042507	FOXO3/CREB5/INSR/PPP2R2A/TBC1D1/TSC1	-0.0963177146719461
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/479	60/9376	0.978705636743215	GNAQ/GNAS/GNA11	-0.0383934503587854
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/479	144/9376	0.951519369055904	FGFR1/BMPR2/SKIL/ZFHX3/JARID2/REST/WNT7A	-0.136029534230121
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/479	103/9376	0.95019964732351	GNAQ/GNAS/FOS/PPP2R2A/GNA11	-0.117915935384024
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/479	18/9376	1.08745070749246	ACSL4	0.0861667393603457
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/479	18/9376	1.08745070749246	MAN2C1	0.0861667393603457
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/479	41/9376	0.954834767554356	PIPOX/MAOA	-0.0672466441783452
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/479	41/9376	0.954834767554356	RAD50/MUS81	-0.0672466441783452
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/479	41/9376	0.954834767554356	EGFR/MMP2	-0.0672466441783452
Organismal Systems	Immune system	hsa04611	Platelet activation	6/479	126/9376	0.932100606422109	ITGB1/GNAQ/GNAS/ROCK2/PPP1R12A/SNAP23	-0.178037669737965
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/479	19/9376	1.0302164597297	NAGLU	0.0305902949763928
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/479	63/9376	0.932100606422109	TCF7L2/GLI3/WNT7A	-0.125465109046914
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/479	42/9376	0.932100606422109	SAT1/ACSL4	-0.102326528842012
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/479	43/9376	0.910423848133223	HADHA/ACSL4	-0.136599023898393
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/479	109/9376	0.897895079580931	GATA3/IL1RAP/FOS/RXRA/HSP90AA1	-0.248783709015683
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	11/479	235/9376	0.916235064185137	CREB5/FGFR1/GNAS/SMARCE1/ACSL4/SMARCC1/NDUFA13/NDUFS1/TSC1/ARID1A/NDUFS6	-0.301738645410217
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/479	44/9376	0.889732397039286	TDG/RFC1	-0.170105559063243
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/479	21/9376	0.932100606422109	DSE	-0.0722745250844272
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/479	21/9376	0.932100606422109	BCAT1	-0.0722745250844272
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/479	45/9376	0.869960565993969	ABCA1/ABCA7	-0.202884482883442
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/479	154/9376	0.889732397039286	TPM1/CREB5/GNAQ/GNAS/ATF4/PPP2R2A/TPM2	-0.320130707857528
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/479	154/9376	0.889732397039286	GNAQ/GNAS/ROCK2/PPP1R12A/FOS/EGFR/MYL6B	-0.320130707857528
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	7/479	155/9376	0.88399218802613	HLA-G/ITGB1/DYNC1I2/TUBA1C/DYNC1LI2/ITGA5/TUBB2A	-0.337905821024156
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/479	156/9376	0.878325571436219	YWHAE/IFNAR1/PPP2R2A/EGFR/RXRA/IRF3/CLDN19	-0.35557216294583
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/479	23/9376	0.851048379776709	PCYOX1	-0.165945424376148
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/479	23/9376	0.851048379776709	RFC1	-0.165945424376148
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/479	70/9376	0.838890545779899	SLC2A1/ACSL4/RXRA	-0.313920821316936
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/479	115/9376	0.851048379776709	CREB5/GNAQ/ATF4/FOS/GNA11	-0.372903800297804
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/479	71/9376	0.827075185980182	JAM2/EGFR/ADAM10	-0.339359414997602
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/479	71/9376	0.827075185980182	FGFR1/SLC2A1/EGFR	-0.339359414997602
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/479	48/9376	0.815588030619346	HADHA/BCAT1	-0.297198802645108
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/479	26/9376	0.752850489802473	HES1	-0.292800775257296
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/479	166/9376	0.825414392434037	CREB5/GNAQ/ROCK2/ATF4/PPP1R12A/INSR/GNA11	-0.526579887217259
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/479	144/9376	0.815588030619346	PSMD1/RB1CC1/PSMC1/PSMC3/GNAQ/ATXN2	-0.517432917286824
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/479	52/9376	0.752850489802473	ABCA1/ANGPTL4	-0.414659761086443
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/479	76/9376	0.772662344797275	EZR/GNAQ/GNAS	-0.461708954856338
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/479	27/9376	0.724967138328307	HADHA	-0.332059178715223
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/479	168/9376	0.815588030619346	XIAP/TNFSF10/IFNAR1/DNM1L/VPS4B/CHMP2B/HSP90AA1	-0.559619309107933
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/479	101/9376	0.77521238553918	TCF7L2/GNAQ/GNAS/WNT7A	-0.526996469549592
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/479	169/9376	0.810762065941125	TAX1BP1/RB1CC1/ATG12/EIF2AK4/OPTN/CALCOCO2/TSC1	-0.576002115528014
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/479	28/9376	0.699075454816582	HADHA	-0.370006093392161
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/479	28/9376	0.699075454816582	ST3GAL6	-0.370006093392161
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	2/479	54/9376	0.724967138328307	AMD1/BCAT1	-0.470282174736813
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/479	54/9376	0.724967138328307	HES1/MUS81	-0.470282174736813
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/479	79/9376	0.743320736766999	AP2B1/SLC17A8/SLC6A2	-0.531574958336071
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/479	149/9376	0.788219304759636	GNAQ/SLC17A8/DAGLB/NDUFA13/NDUFS1/NDUFS6	-0.604617680987331
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/479	80/9376	0.734029227557411	FOXO3/EIF4E2/EGFR	-0.554322427474387
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/479	105/9376	0.745680485137688	XIAP/PPP1R13L/ERC1/EDARADD	-0.608054693473207
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/479	30/9376	0.652470424495477	SUCLG1	-0.44235517111175
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/479	30/9376	0.652470424495477	PIGT	-0.44235517111175
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/479	57/9376	0.686810973153133	HADHA/ACSL4	-0.550289098034204
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/479	31/9376	0.631422991447235	H6PD	-0.476926039081699
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/479	31/9376	0.631422991447235	HADHA	-0.476926039081699
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/479	83/9376	0.707498050657746	IRF3/POLR2F/POLR2L	-0.621042672398162
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/479	59/9376	0.663529245249637	GNAS/INSR	-0.601543280697223
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/479	32/9376	0.611691022964509	UGP2	-0.510525694391325
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/479	32/9376	0.611691022964509	ATG12	-0.510525694391325
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/479	32/9376	0.611691022964509	XIAP	-0.510525694391325
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/479	224/9376	0.786459886668655	IL1R2/CREB5/HLA-G/XIAP/SLC2A1/ATF4/FOS/EGR1/ANAPC7	-0.750545580392192
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/479	60/9376	0.652470424495477	PXN/PTK2	-0.626591147358738
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/479	86/9376	0.682817886099917	EGFR/PTK2/CRK	-0.685617126268821
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/479	33/9376	0.593154931359524	BCAT1	-0.543218374232326
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/479	158/9376	0.743320736766999	EIF4E2/CLIP1/INSR/EIF4B/WNT7A/TSC1	-0.754975007749182
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	3/479	87/9376	0.674969404650493	TCF7L2/FOS/EGFR	-0.706693322688213
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/479	62/9376	0.631422991447235	FOXO3/INSR	-0.675596776078349
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/479	63/9376	0.621400404281406	HPGD/PTGDS	-0.699579731996578
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/479	90/9376	0.652470424495477	SLC2A1/GNAS/RXRA	-0.768652925693278
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/479	36/9376	0.543725353746231	UGP2	-0.636408173833714
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/479	36/9376	0.543725353746231	UGP2	-0.636408173833714
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/479	36/9376	0.543725353746231	RFC1	-0.636408173833714
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	4/479	116/9376	0.674969404650493	SLC38A1/GNAQ/GNAS/SLC17A8	-0.817295945098049
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/479	65/9376	0.602280391841978	GNAQ/GNA11	-0.746564126295968
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/479	37/9376	0.529030073915251	GFPT1	-0.666001872133278
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/479	37/9376	0.529030073915251	MAOA	-0.666001872133278
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/479	67/9376	0.584301872682516	GNAQ/ATF4	-0.792310759924988
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/479	38/9376	0.51510822986485	NT5E	-0.694930345176452
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/479	38/9376	0.51510822986485	INSR	-0.694930345176452
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	9/479	238/9376	0.740197540394028	IGF2/FGFR1/RASGRF2/INSR/RASAL2/FLT1/EGFR/SHOC2/KSR1	-0.941971492400265
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	7/479	193/9376	0.709941912663472	PARD3/FOXO3/GNAQ/ROCK2/PXN/PTK2/CRK	-0.944719632918154
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/479	39/9376	0.501900326534982	HLA-G	-0.723230080151739
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/479	69/9376	0.567365586517806	GNAQ/GNAS	-0.836897653232028
NA	NA	hsa04081	Hormone signaling	8/479	219/9376	0.715036081638878	IGF2/GNAQ/GNAS/THRB/CSH1/INSR/PTH1R/GNA11	-0.990072331290158
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/479	97/9376	0.605384929944257	GNAQ/GNAS/FOS	-0.906443097115001
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/479	98/9376	0.599207532699928	DGKZ/INPP5A/PI4KA	-0.925415999972531
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/479	41/9376	0.477417383777178	SLC17A8	-0.778074756710662
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	5/479	149/9376	0.65684942063303	GNAS/INSR/EGFR/DGKZ/TSC1	-0.979668648697369
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/479	71/9376	0.551383457320121	FOXO3/FOS	-0.880395612075909
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/479	150/9376	0.652470424495477	TCF7L2/EGFR/RXRA/WNT7A/CSNK1A1	-0.995548159707979
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/479	99/9376	0.593154931359524	GNAQ/GNAS/IL1RAP	-0.944222782282234
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/479	125/9376	0.626371607515658	GNAQ/ROCK2/PPP2R2A/ASAH1	-0.975735569435498
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/479	72/9376	0.543725353746231	ATG12/IRF3	-0.901756609176824
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/479	73/9376	0.536277061229159	SUPT5H/VPS4B	-0.922869086676355
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/479	73/9376	0.536277061229159	FGFR1/EGFR	-0.922869086676355
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/479	43/9376	0.455211924066612	ABCA1	-0.830773792500741
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/479	227/9376	0.689836572153808	FOXO3/FOS/NDUFA13/EGFR/PRKD3/NDUFS1/PTK2/NDUFS6	-1.0976106243776
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/479	44/9376	0.444866198519643	HLA-G	-0.856383408364864
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	7/479	205/9376	0.668384337288049	SLC2A1/INSR/NDUFA13/NDUFS1/GFPT1/MMP2/NDUFS6	-1.11387182351846
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/479	45/9376	0.434980282996984	HLA-G	-0.881530544786814
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	3/479	104/9376	0.564637867351855	CHKB/DGKZ/LPCAT1	-1.03588658684712
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/479	157/9376	0.623379386460647	RAD50/ZFP36L1/FOXO3/HLA-G/TSC1	-1.10418947928865
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/479	77/9376	0.508418512593878	CTBP2/CRK	-1.00497291595695
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/479	78/9376	0.501900326534982	INPP5A/PI4KA	-1.0249445891443
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/479	78/9376	0.501900326534982	ITGB1/FOS	-1.0249445891443
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/479	47/9376	0.416470483720517	GLO1	-0.930520211261336
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/479	47/9376	0.416470483720517	INSR	-0.930520211261336
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/479	109/9376	0.538737047748559	FOS/IFNAR1/IRF3	-1.12389008895605
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/479	163/9376	0.600432905977432	CREB5/ATF4/FOS/IFNAR1/IRF3	-1.19402819305076
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/479	138/9376	0.567365586517806	YWHAE/SMC3/SLK/ANAPC7	-1.18796385193143
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/479	83/9376	0.471665367105164	PIPOX/ACSL4	-1.12176466882134
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/479	51/9376	0.383806132056163	LPCAT1	-1.02378706825138
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/479	85/9376	0.460567358467395	ADK/NT5E	-1.15916979200799
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/479	115/9376	0.510629027866025	GNAQ/GNAS/MAOA	-1.22515146186812
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/479	87/9376	0.449979603100329	TPM1/TPM2	-1.19587431888789
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/479	54/9376	0.362483569164154	HLA-G	-1.09009742218303
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/479	173/9376	0.565725801585673	TNFSF10/IFNAR1/KPNA6/IRF3/CALCOCO2	-1.3376853398442
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	2/479	90/9376	0.434980282996984	FOS/EGFR	-1.24968949165912
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/479	93/9376	0.420948660964824	GATA3/FOS	-1.30210488710437
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/479	93/9376	0.420948660964824	GNAQ/GNAS	-1.30210488710437
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/479	59/9376	0.331764622624819	NT5E	-1.1946729262769
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	2/479	95/9376	0.41208658389188	FOS/FLT1	-1.33631667212649
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/479	128/9376	0.458768267223382	ADK/NT5E/NUDT9	-1.43052655990634
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/479	98/9376	0.399471688466618	DOCK1/CRK	-1.38659918354553
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/479	65/9376	0.301140195920989	DGKZ	-1.31183790875183
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/479	66/9376	0.296577465679762	CYP11A1	-1.33059229369306
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/479	66/9376	0.296577465679762	GATA3	-1.33059229369306
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/479	133/9376	0.441521339884157	HLA-G/TNFSF10/IFNAR1	-1.50507286753523
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	2/479	102/9376	0.383806132056163	GNAQ/GNAS	-1.45182914957001
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	10/479	323/9376	0.606009682193941	TPM1/EZR/SOX4/ITGA5/BMPR2/EGFR/PDCD4/CRK/STMN1/HNRNPK	-1.67194562766318
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/479	68/9376	0.287854599042122	TCF7L2	-1.36749750496386
Human Diseases	Infectious disease: viral	hsa05162	Measles	3/479	136/9376	0.431781898563183	FOS/IFNAR1/IRF3	-1.54874576886909
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/479	105/9376	0.372840242568844	PLK3/KSR1	-1.49948160395789
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/479	250/9376	0.5480751565762	CTSV/AP2B1/BLOC1S6/NAGLU/AP3B1/SLC17A5/ASAH1	-1.68045771145626
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/479	196/9376	0.499339610583273	TCF7L2/HLA-G/FOS/IFNAR1/IRF3	-1.64354472764041
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/479	138/9376	0.425524189888354	NDUFA13/NDUFS1/NDUFS6	-1.57744385318009
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	4/479	168/9376	0.466050303211055	CSF2RB/CSH1/IFNAR1/EGFR	-1.62033170308286
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	6/479	226/9376	0.519666709775158	CREB5/GNAS/ROCK2/PPP1R12A/FOS/GLI3	-1.69596919368849
NA	NA	hsa04082	Neuroactive ligand signaling	5/479	199/9376	0.49181187776041	GNAQ/GNAS/SLC17A8/SLC6A2/GNA11	-1.68124994115866
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	7/479	254/9376	0.539444051748229	FGFR1/GNAQ/GNAS/FLT1/EGFR/PHKA2/GNA11	-1.72657647690117
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/479	73/9376	0.268138530614579	MAOA	-1.45649970996821
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/479	110/9376	0.355892958815715	ANAPC7/HSP90AA1	-1.57666650333031
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/479	144/9376	0.407794015309673	TCF7L2/FOXO3/IRF3	-1.66164306645693
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/479	75/9376	0.260988169798191	BCAT1	-1.49090097866761
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/479	75/9376	0.260988169798191	XIAP	-1.49090097866761
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/479	75/9376	0.260988169798191	PPP1R13L	-1.49090097866761
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/479	76/9376	0.257554114932425	EGFR	-1.50786244947524
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/479	77/9376	0.254209256296939	EGFR	-1.52466990233455
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/479	116/9376	0.337484702325247	H6PD/SUCLG1	-1.66590799174692
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/479	154/9376	0.381313884445408	UGP2/BCAT1/VKORC1	-1.79617964657018
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/479	298/9376	0.525479536506424	IL1R2/INHA/CSF2RB/TNFSF10/BMPR2/IL1RAP/CSH1/IFNAR1	-1.93152168545073
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/479	122/9376	0.320887094014169	FOS/PPP2R2A	-1.75181705979416
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/479	86/9376	0.227605962033306	SCN9A	-1.66959786649482
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/479	191/9376	0.409929062510247	CREB5/GNAS/ATF4/MAOA	-1.91167001402002
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/479	89/9376	0.219933850953531	SLC38A1	-1.71561688655432
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/479	91/9376	0.215100139943564	FOS	-1.74572404347285
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/479	91/9376	0.215100139943564	GNAS	-1.74572404347285
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/479	99/9376	0.197718310453175	C1S	-1.86196836945667
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/479	140/9376	0.279630181926633	GNAQ/EGR1	-1.99254970505205
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/479	100/9376	0.195741127348643	TNFSF10	-1.87606158353684
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/479	142/9376	0.275691728660061	FOS/IFNAR1	-2.01792156441267
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/479	143/9376	0.273763814473627	C1S/ACTN4	-2.03051445204267
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/479	181/9376	0.324432807760182	PLK3/KSR1/CEBPB	-2.12943099378354
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/479	370/9376	0.211612029566101	THRB/CSH1/PTH1R/LYPD6B	-3.59009945108734