category subcategory ID Description GeneRatio BgRatio FoldEnrichment geneName zScore Metabolism Energy metabolism hsa00190 Oxidative phosphorylation 6/43 138/9376 9.48028311425682 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/MT-CYB/MT-ND2 6.81192956515471 Organismal Systems Environmental adaptation hsa04714 Thermogenesis 7/43 235/9376 6.49500247402276 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/FGFR1/MT-CYB/MT-ND2 5.79047514823021 Human Diseases Cancer: overview hsa05205 Proteoglycans in cancer 6/43 204/9376 6.41313269493844 TIMP3/FN1/LUM/FGFR1/DCN/CTSL 5.30567895074482 Human Diseases Cardiovascular disease hsa05415 Diabetic cardiomyopathy 6/43 205/9376 6.38184912081679 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/MT-CYB/MT-ND2 5.28821781772967 Human Diseases Neurodegenerative disease hsa05016 Huntington disease 7/43 308/9376 4.95560253699789 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/MT-CYB/TGM2/MT-ND2 4.7911689146531 Human Diseases Cancer: overview hsa05208 Chemical carcinogenesis - reactive oxygen species 6/43 227/9376 5.76334391968036 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/MT-CYB/MT-ND2 4.93113948210998 Organismal Systems Circulatory system hsa04260 Cardiac muscle contraction 4/43 87/9376 10.025126971398 MT-CO2/MT-CO3/MT-CYB/TPM1 5.74034108528583 Human Diseases Neurodegenerative disease hsa05012 Parkinson disease 6/43 268/9376 4.88163832002777 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/MT-CYB/MT-ND2 4.37602894283196 Human Diseases Neurodegenerative disease hsa05020 Prion disease 6/43 275/9376 4.75737843551797 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/MT-CYB/MT-ND2 4.29255591820258 Human Diseases Neurodegenerative disease hsa05014 Amyotrophic lateral sclerosis 6/43 368/9376 3.55510616784631 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/MT-CYB/MT-ND2 3.39412555768912 Organismal Systems Immune system hsa04610 Complement and coagulation cascades 3/43 88/9376 7.43340380549683 CD59/SERPINB2/PROCR 4.11557269686669 Human Diseases Neurodegenerative disease hsa05010 Alzheimer disease 6/43 388/9376 3.3718532725965 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/MT-CYB/MT-ND2 3.23877951121745 Environmental Information Processing Signaling molecules and interaction hsa04060 Cytokine-cytokine receptor interaction 5/43 298/9376 3.65849851724676 PRL/TNFSF10/IL1RL1/EBI3/IL1R2 3.16561939683084 Metabolism Carbohydrate metabolism hsa00520 Amino sugar and nucleotide sugar metabolism 2/43 38/9376 11.4761321909425 HEXB/UGDH 4.39212879024062 Human Diseases Cancer: overview hsa05202 Transcriptional misregulation in cancer 4/43 201/9376 4.3392340622469 IGFBP3/FLT1/ASPSCR1/IL1R2 3.24826226632543 Environmental Information Processing Signal transduction hsa04066 HIF-1 signaling pathway 3/43 110/9376 5.94672304439746 FLT1/EGLN3/LDHA 3.54223217562171 Human Diseases Neurodegenerative disease hsa05022 Pathways of neurodegeneration - multiple diseases 6/43 480/9376 2.72558139534884 MT-CO2/MT-ATP6/MT-CO3/MT-ND4/MT-CYB/MT-ND2 2.63431627111202 Human Diseases Endocrine and metabolic disease hsa04932 Non-alcoholic fatty liver disease 3/43 157/9376 4.16649385276255 MT-CO2/MT-CO3/MT-CYB 2.71578759999219 Human Diseases Cancer: overview hsa05230 Central carbon metabolism in cancer 2/43 71/9376 6.14215525712414 FGFR1/LDHA 2.95206152041819 Organismal Systems Immune system hsa04612 Antigen processing and presentation 2/43 82/9376 5.31820760068066 HLA-C/CTSL 2.66574340037109 Metabolism Glycan biosynthesis and metabolism hsa00604 Glycosphingolipid biosynthesis - ganglio series 1/43 15/9376 14.5364341085271 HEXB 3.56121352064177 Human Diseases Immune disease hsa05323 Rheumatoid arthritis 2/43 95/9376 4.59045287637699 FLT1/CTSL 2.3873873068478 Metabolism Glycan biosynthesis and metabolism hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 1/43 16/9376 13.6279069767442 HEXB 3.43133147542195 Organismal Systems Immune system hsa04640 Hematopoietic cell lineage 2/43 100/9376 4.36093023255814 CD59/IL1R2 2.29344516265853 NA NA hsa04382 Cornified envelope formation 3/43 217/9376 3.01446790268996 KRT19/S100A13/PCSK6 2.03786505653282 Metabolism Glycan biosynthesis and metabolism hsa00511 Other glycan degradation 1/43 18/9376 12.1136950904393 HEXB 3.20340937867233 Human Diseases Infectious disease: parasitic hsa05146 Amoebiasis 2/43 103/9376 4.23391284714382 FN1/IL1R2 2.23998973004385 Environmental Information Processing Signal transduction hsa04151 PI3K-Akt signaling pathway 4/43 362/9376 2.40935371964538 PRL/FN1/FLT1/FGFR1 1.85619991098332 Metabolism Glycan biosynthesis and metabolism hsa00531 Glycosaminoglycan degradation 1/43 19/9376 11.4761321909425 HEXB 3.10254928159801 Human Diseases Cancer: specific types hsa05215 Prostate cancer 2/43 106/9376 4.11408512505485 FGFR1/IL1R2 2.1885313830738 Metabolism Glycan biosynthesis and metabolism hsa00541 Biosynthesis of various nucleotide sugars 1/43 20/9376 10.9023255813953 UGDH 3.00895938637507 Cellular Processes Cell motility hsa04820 Cytoskeleton in muscle cells 3/43 233/9376 2.80746581495159 FN1/DCN/TPM1 1.89632567797538 Metabolism Glycan biosynthesis and metabolism hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1/43 21/9376 10.3831672203765 CHPF 2.92177279248879 Organismal Systems Endocrine system hsa04614 Renin-angiotensin system 1/43 23/9376 9.48028311425682 PRCP 2.76380905479012 Organismal Systems Immune system hsa04650 Natural killer cell mediated cytotoxicity 2/43 133/9376 3.27889491169785 TNFSF10/HLA-C 1.79660612419608 Cellular Processes Cell growth and death hsa04210 Apoptosis 2/43 137/9376 3.18316075369207 TNFSF10/CTSL 1.74720051321885 Metabolism Carbohydrate metabolism hsa00053 Ascorbate and aldarate metabolism 1/43 31/9376 7.0337584396099 UGDH 2.28395922573943 Metabolism Carbohydrate metabolism hsa00640 Propanoate metabolism 1/43 32/9376 6.81395348837209 LDHA 2.23609041722694 Human Diseases Immune disease hsa05310 Asthma 1/43 32/9376 6.81395348837209 PRG2 2.23609041722694 Human Diseases Cardiovascular disease hsa05418 Fluid shear stress and atherosclerosis 2/43 142/9376 3.07107762856207 IL1R2/CTSL 1.68793161527303 Organismal Systems Nervous system hsa04723 Retrograde endocannabinoid signaling 2/43 149/9376 2.92679881379741 MT-ND4/MT-ND2 1.60919426918785 Metabolism Carbohydrate metabolism hsa00040 Pentose and glucuronate interconversions 1/43 36/9376 6.05684754521964 UGDH 2.06332151137037 Metabolism Global and overview maps hsa01250 Biosynthesis of nucleotide sugars 1/43 37/9376 5.89314896291641 UGDH 2.02417634211476 NA NA hsa04518 Integrin signaling 2/43 154/9376 2.83177287828451 FN1/FLT1 1.55571005611879 Cellular Processes Transport and catabolism hsa04145 Phagosome 2/43 155/9376 2.81350337584396 HLA-C/CTSL 1.54527023574166 Cellular Processes Cell growth and death hsa04218 Cellular senescence 2/43 157/9376 2.77766256850837 IGFBP3/HLA-C 1.52463708600394 Human Diseases Immune disease hsa05330 Allograft rejection 1/43 39/9376 5.59093619558736 HLA-C 1.95002021806607 Metabolism Glycan biosynthesis and metabolism hsa00513 Various types of N-glycan biosynthesis 1/43 44/9376 4.95560253699789 HEXB 1.7850930248826 Human Diseases Endocrine and metabolic disease hsa04940 Type I diabetes mellitus 1/43 44/9376 4.95560253699789 HLA-C 1.7850930248826 Human Diseases Immune disease hsa05332 Graft-versus-host disease 1/43 45/9376 4.84547803617571 HLA-C 1.75509945123864 Metabolism Carbohydrate metabolism hsa00620 Pyruvate metabolism 1/43 47/9376 4.63928748144483 LDHA 1.6976844825076 Metabolism Amino acid metabolism hsa00270 Cysteine and methionine metabolism 1/43 54/9376 4.03789836347976 LDHA 1.51958432009716 Human Diseases Immune disease hsa05320 Autoimmune thyroid disease 1/43 54/9376 4.03789836347976 HLA-C 1.51958432009716 Metabolism Lipid metabolism hsa00600 Sphingolipid metabolism 1/43 55/9376 3.96448202959831 HEXB 1.49660828772334 Metabolism Metabolism of other amino acids hsa00480 Glutathione metabolism 1/43 59/9376 3.69570358691368 PRDX6 1.40983837506968 Cellular Processes Cellular community - eukaryotes hsa04510 Focal adhesion 2/43 203/9376 2.14824149387101 FN1/FLT1 1.12262521389356 Metabolism Lipid metabolism hsa00590 Arachidonic acid metabolism 1/43 63/9376 3.46105574012551 PTGDS 1.33032011062089 Environmental Information Processing Signal transduction hsa04015 Rap1 signaling pathway 2/43 212/9376 2.05704256252742 FLT1/FGFR1 1.05664012372425 Metabolism Lipid metabolism hsa00140 Steroid hormone biosynthesis 1/43 66/9376 3.30373502466526 HSD11B1 1.27479069700756 Metabolism Carbohydrate metabolism hsa00010 Glycolysis / Gluconeogenesis 1/43 67/9376 3.25442554668518 LDHA 1.25698766641738 Human Diseases Infectious disease: viral hsa05166 Human T-cell leukemia virus 1 infection 2/43 224/9376 1.9468438538206 HLA-C/IL1R2 0.973539553417909 Human Diseases Cancer: overview hsa05204 Chemical carcinogenesis - DNA adducts 1/43 70/9376 3.11495016611296 HSD11B1 1.20552679466374 Human Diseases Cancer: specific types hsa05211 Renal cell carcinoma 1/43 70/9376 3.11495016611296 EGLN3 1.20552679466374 Human Diseases Cardiovascular disease hsa05416 Viral myocarditis 1/43 70/9376 3.11495016611296 HLA-C 1.20552679466374 Organismal Systems Endocrine system hsa04917 Prolactin signaling pathway 1/43 71/9376 3.07107762856207 PRL 1.18898560377121 Genetic Information Processing Information processing in viruses hsa03250 Viral life cycle - HIV-1 1/43 73/9376 2.98693851545078 SERINC3 1.1567608481129 Human Diseases Cancer: specific types hsa05218 Melanoma 1/43 73/9376 2.98693851545078 FGFR1 1.1567608481129 Cellular Processes Cell motility hsa04810 Regulation of actin cytoskeleton 2/43 232/9376 1.87971130713713 FN1/FGFR1 0.920927180238819 Cellular Processes Cell growth and death hsa04115 p53 signaling pathway 1/43 75/9376 2.90728682170543 IGFBP3 1.12561805509589 Environmental Information Processing Signal transduction hsa04014 Ras signaling pathway 2/43 238/9376 1.83232362712527 FLT1/FGFR1 0.882804133257223 Human Diseases Infectious disease: bacterial hsa05100 Bacterial invasion of epithelial cells 1/43 78/9376 2.79546809779368 FN1 1.08078536790162 Metabolism Xenobiotics biodegradation and metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 1/43 79/9376 2.76008242566971 HSD11B1 1.06631217952636 Cellular Processes Transport and catabolism hsa04142 Lysosome biogenesis 2/43 250/9376 1.74437209302326 HEXB/CTSL 0.809709226440023 Environmental Information Processing Signal transduction hsa04020 Calcium signaling pathway 2/43 254/9376 1.71690166636147 FLT1/FGFR1 0.786213772476451 Environmental Information Processing Signaling molecules and interaction hsa04512 ECM-receptor interaction 1/43 89/9376 2.44996080480794 FN1 0.932873542749697 Cellular Processes Cellular community - eukaryotes hsa04520 Adherens junction 1/43 93/9376 2.34458614653663 FGFR1 0.884494556542851 Human Diseases Cancer: specific types hsa05222 Small cell lung cancer 1/43 93/9376 2.34458614653663 FN1 0.884494556542851 Human Diseases Infectious disease: bacterial hsa05150 Staphylococcus aureus infection 1/43 99/9376 2.2024900164435 KRT19 0.816402886305459 Human Diseases Cardiovascular disease hsa05410 Hypertrophic cardiomyopathy 1/43 99/9376 2.2024900164435 TPM1 0.816402886305459 Environmental Information Processing Signaling molecules and interaction hsa04061 Viral protein interaction with cytokine and cytokine receptor 1/43 100/9376 2.18046511627907 TNFSF10 0.805530559483441 Human Diseases Endocrine and metabolic disease hsa04933 AGE-RAGE signaling pathway in diabetic complications 1/43 101/9376 2.15887635275155 FN1 0.794785731649604 Organismal Systems Digestive system hsa04974 Protein digestion and absorption 1/43 103/9376 2.11695642357191 PRCP 0.773666773338471 Human Diseases Cardiovascular disease hsa05414 Dilated cardiomyopathy 1/43 105/9376 2.0766334440753 TPM1 0.753023376596579 Organismal Systems Endocrine system hsa04922 Glucagon signaling pathway 1/43 107/9376 2.03781786568137 LDHA 0.732834359714766 Organismal Systems Immune system hsa04659 Th17 cell differentiation 1/43 109/9376 2.00042671218263 EBI3 0.713079875118165 Environmental Information Processing Signal transduction hsa04350 TGF-beta signaling pathway 1/43 110/9376 1.98224101479915 DCN 0.703359718263888 Environmental Information Processing Signal transduction hsa04010 MAPK signaling pathway 2/43 300/9376 1.45364341085271 FLT1/FGFR1 0.542047348041246 Organismal Systems Endocrine system hsa04928 Parathyroid hormone synthesis, secretion and action 1/43 115/9376 1.89605662285136 FGFR1 0.656242971796147 Organismal Systems Endocrine system hsa04935 Growth hormone synthesis, secretion and action 1/43 122/9376 1.78726648875334 IGFBP3 0.594081688495385 Human Diseases Cancer: overview hsa05206 MicroRNAs in cancer 2/43 323/9376 1.35013319893441 TIMP3/TPM1 0.434657848242281 Human Diseases Infectious disease: viral hsa05165 Human papillomavirus infection 2/43 333/9376 1.30958865842587 FN1/HLA-C 0.390445234605454 Environmental Information Processing Signal transduction hsa04068 FoxO signaling pathway 1/43 133/9376 1.63944745584892 TNFSF10 0.504119434986963 Human Diseases Infectious disease: bacterial hsa05135 Yersinia infection 1/43 138/9376 1.58004718570947 FN1 0.465932625159225 Organismal Systems Endocrine system hsa04915 Estrogen signaling pathway 1/43 139/9376 1.56867993976912 KRT19 0.458478600887498 Cellular Processes Cellular community - eukaryotes hsa04550 Signaling pathways regulating pluripotency of stem cells 1/43 144/9376 1.51421188630491 FGFR1 0.422070202389742 Human Diseases Cancer: specific types hsa05224 Breast cancer 1/43 148/9376 1.4732872407291 FGFR1 0.393922778393187 Metabolism Global and overview maps hsa01240 Biosynthesis of cofactors 1/43 154/9376 1.41588643914225 UGDH 0.353209026756071 Organismal Systems Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes 1/43 154/9376 1.41588643914225 TPM1 0.353209026756071 Environmental Information Processing Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction 2/43 370/9376 1.17862979258328 TAC3/PRL 0.2379567439821 Cellular Processes Cell growth and death hsa04110 Cell cycle 1/43 158/9376 1.38004121283485 CDKN1C 0.327001782523522 Environmental Information Processing Signaling molecules and interaction hsa04514 Cell adhesion molecule (CAM) interaction 1/43 160/9376 1.36279069767442 HLA-C 0.314162348011273 Cellular Processes Cell growth and death hsa04217 Necroptosis 1/43 168/9376 1.29789590254707 TNFSF10 0.264451325595702 Environmental Information Processing Signal transduction hsa04630 JAK-STAT signaling pathway 1/43 168/9376 1.29789590254707 PRL 0.264451325595702 Cellular Processes Transport and catabolism hsa04140 Autophagy - animal 1/43 169/9376 1.29021604513554 CTSL 0.258413342372804 Human Diseases Infectious disease: viral hsa05164 Influenza A 1/43 173/9376 1.26038446027692 TNFSF10 0.234629511085281 NA NA hsa04519 Cadherin signaling 2/43 404/9376 1.07943817637578 KRT19/FGFR1 0.11078591498099 Human Diseases Infectious disease: viral hsa05168 Herpes simplex virus 1 infection 1/43 180/9376 1.21136950904393 HLA-C 0.194351699646693 Cellular Processes Cell motility hsa04814 Motor proteins 1/43 194/9376 1.1239510908655 TPM1 0.118410934088198 Human Diseases Infectious disease: viral hsa05167 Kaposi sarcoma-associated herpesvirus infection 1/43 196/9376 1.1124822021832 HLA-C 0.10801889706089 NA NA hsa04082 Neuroactive ligand signaling 1/43 199/9376 1.09571111370808 TAC3 0.0926291705564531 Human Diseases Infectious disease: bacterial hsa05130 Pathogenic Escherichia coli infection 1/43 200/9376 1.09023255813953 TNFSF10 0.0875509370127873 Human Diseases Infectious disease: viral hsa05169 Epstein-Barr virus infection 1/43 205/9376 1.06364152013613 HLA-C 0.062534309895372 Human Diseases Cancer: overview hsa05203 Viral carcinogenesis 1/43 205/9376 1.06364152013613 HLA-C 0.062534309895372 Human Diseases Infectious disease: viral hsa05170 Human immunodeficiency virus 1 infection 1/43 214/9376 1.01890893284069 HLA-C 0.0189927562838046 Human Diseases Cardiovascular disease hsa05417 Lipid and atherosclerosis 1/43 216/9376 1.00947459086994 TNFSF10 0.00956200215498732 NA NA hsa04081 Hormone signaling 1/43 219/9376 0.995646171816927 PRL -0.00442512934709234 Genetic Information Processing Translation hsa03010 Ribosome 1/43 222/9376 0.982191493819401 RPS4Y1 -0.0182266879206397 Human Diseases Infectious disease: viral hsa05163 Human cytomegalovirus infection 1/43 227/9376 0.960557319946727 HLA-C -0.0408321045405385 Human Diseases Infectious disease: viral hsa05171 Coronavirus disease - COVID-19 1/43 238/9376 0.916161813562634 RPS4Y1 -0.0889229803163534 Human Diseases Infectious disease: bacterial hsa05132 Salmonella infection 1/43 248/9376 0.879219804951238 TNFSF10 -0.130840737797386 Cellular Processes Transport and catabolism hsa04144 Endocytosis 1/43 250/9376 0.872186046511628 HLA-C -0.139032801440714 NA NA hsa04517 IgSF CAM signaling 1/43 299/9376 0.729252547250525 FGFR1 -0.322952044973054