category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	25/256	233/9376	3.92972103004292	FBN1/ITGA6/FBN2/DIAPH2/FN1/FBLN1/DSG2/ITGB4/DSP/DAG1/ITGAV/SYNE2/INF2/ATP1B3/DSC2/FMNL2/BGN/TPM1/FHL2/ITGB1/DIAPH1/TMEM43/ANK3/SGCE/ATP1A1	7.58696482960386
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	17/256	174/9376	3.57830459770115	HSP90B1/TUSC3/HSPA5/LMAN1/CALR/PDIA6/OS9/SEC62/MOGS/RPN1/PDIA3/P4HB/GANAB/TRAM1/SIL1/SSR4/ERP29	5.75143127156023
NA	NA	hsa04518	Integrin signaling	15/256	154/9376	3.56737012987013	EGFR/FLT1/FBN1/ITGA6/LAMC1/FN1/LAMA5/LAMB1/ITGB4/MET/ITGAV/CDH1/ACTN4/ITGB1/PIK3CB	5.38200983752921
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/256	86/9376	4.68459302325581	ITGA6/DSG2/ITGB4/DSP/DAG1/ITGAV/DSC2/GJA1/ITGB1/TCF7L2/SGCE	5.75094343176311
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	5/256	18/9376	10.1736111111111	HEXB/GLB1/HEXA/FUCA1/MANBA	6.52669411704878
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/256	203/9376	2.88669950738916	EGFR/FLT1/ITGA6/LAMC1/FN1/LAMA5/LAMB1/ITGB4/MET/ITGAV/ACTN4/ITGB1/DIAPH1/PIK3CB/PPP1R12B/VAV3	4.55305881001101
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/256	204/9376	2.87254901960784	TIMP3/CTSL/EGFR/FN1/IGF2/MET/ITGAV/EZR/IQGAP1/ITGB1/ERBB3/PIK3CB/ANK3/WNT5A/PPP1R12B/VAV3	4.5302738754333
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/256	89/9376	4.11516853932584	ITGA6/LAMC1/FN1/LAMA5/LAMB1/ITGB4/DAG1/ITGAV/CD47/ITGB1	4.94705832228658
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	24/256	388/9376	2.26546391752577	MT-CO3/APP/MT-CO1/MT-ND4/MT-ND4L/MT-CO2/MT-ND5/DVL3/MT-ND2/MT-ATP8/RTN3/MT-ND1/RTN4/SLC39A7/MT-ATP6/LRP1/MT-CYB/APH1A/MME/PIK3CB/WNT5A/LRP5/NCSTN/WIPI2	4.26522846729072
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	18/256	250/9376	2.637	CTSL/HEXB/CTSV/GLB1/HEXA/FUCA1/MANBA/SLC38A9/LAMP2/GAA/VPS13A/AP2A2/NPC1/ATP6V1B1/CLTC/RRAGA/SLC29A1/GM2A	4.39528107611221
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	17/256	232/9376	2.68372844827586	EGFR/ITGA6/DIAPH2/FN1/ITGB4/GNA12/ITGAV/ACTN4/EZR/IQGAP1/WASF2/ITGB1/SCIN/DIAPH1/PIK3CB/PPP1R12B/VAV3	4.35066992088877
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/256	93/9376	3.93817204301075	ITGA6/LAMC1/FN1/LAMA5/LAMB1/ITGAV/GADD45G/ITGB1/PIK3CB/GADD45A	4.77070676126695
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/256	138/9376	3.18478260869565	MT-CO3/MT-CO1/MT-ND4/MT-ND4L/MT-CO2/MT-ND5/MT-ND2/MT-ATP8/MT-ND1/MT-ATP6/ATP6V1B1/MT-CYB	4.33178602648911
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	16/256	227/9376	2.58149779735683	SLC26A2/EGFR/MT-CO3/MT-CO1/MT-ND4/FOS/MT-ND4L/MT-CO2/MT-ND5/MET/MT-ND2/MT-ATP8/MT-ND1/MT-ATP6/MT-CYB/PIK3CB	4.04113080296831
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	13/256	170/9376	2.80073529411765	EGFR/IGF2/MET/DVL3/TGFBR1/GADD45G/TCF7L2/SMARCA2/PIK3CB/WNT5A/LRP5/SMARCC1/GADD45A	3.96960280542888
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/256	93/9376	3.54435483870968	EGFR/PTPRF/MET/CDH1/ACTN4/TGFBR1/IQGAP1/WASF2/TCF7L2	4.13126619353995
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/256	17/9376	8.61764705882353	DAG1/TFRC/NRP2/LAMP2	5.26670248429796
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	14/256	205/9376	2.50121951219512	MT-CO3/MT-CO1/SLC2A1/MT-ND4/MT-ND4L/MT-CO2/MT-ND5/MT-ND2/MT-ATP8/MT-ND1/TGFBR1/MT-ATP6/MT-CYB/PIK3CB	3.64100257472492
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/256	87/9376	3.36781609195402	MT-CO3/MT-CO1/MT-CO2/ATP1B3/ASPH/TPM1/MT-CYB/ATP1A1	3.71733169229225
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	11/256	150/9376	2.68583333333333	EGFR/MET/DVL3/CDH1/TGFBR1/GADD45G/TCF7L2/PIK3CB/WNT5A/LRP5/GADD45A	3.48707864951739
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/256	53/9376	4.14622641509434	ATP1B3/ATP2B4/ATP2B1/AP2A2/CLTC/ATP1A1	3.84820560102625
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/256	155/9376	2.5991935483871	CTSL/PLA2R1/CALR/COLEC12/TFRC/ITGAV/EEA1/LAMP2/ITGB1/ATP6V1B1/DYNC1LI2	3.3634584635613
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	7/256	75/9376	3.41833333333333	LRP2/HSP90B1/GPX3/HSPA5/ATP1B3/ATP1A1/GPX8	3.52281772850283
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	14/256	235/9376	2.18191489361702	MT-CO3/MT-CO1/MT-ND4/MT-ND4L/MT-CO2/MT-ND5/MT-ND2/MT-ATP8/MT-ND1/MT-ATP6/ACSL3/SMARCA2/MT-CYB/SMARCC1	3.07419550840327
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/256	59/9376	3.72457627118644	EGFR/CDH1/GADD45G/TCF7L2/PIK3CB/GADD45A	3.51718433105608
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/256	78/9376	3.28685897435897	FN1/MET/CDH1/WASF2/ITGB1/CLTC/PIK3CB	3.39781802227175
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/256	99/9376	2.95959595959596	ITGA6/ITGB4/DAG1/ITGAV/TPM1/ITGB1/SGCE/EDN1	3.28388965848208
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/256	15/9376	7.325	HEXB/GLB1/HEXA	4.10726986188513
NA	NA	hsa04519	Cadherin signaling	20/256	404/9376	1.81311881188119	EGFR/DSG2/DSP/KRT19/MET/GABRE/DVL3/CDH1/DSC2/ACTN4/TEAD1/MPDZ/GJA1/TCF7L2/DSC3/APH1A/WNT5A/LRP5/NCSTN/VAV3	2.79903455867037
NA	NA	hsa04517	IgSF CAM signaling	16/256	299/9376	1.95986622073579	APP/PTPRF/NRP2/CDH1/CADM1/PPFIA1/ACTN4/EZR/NRCAM/IQGAP1/MPDZ/NRP1/ITGB1/PIK3CB/ANK3/VAV3	2.82607274405136
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/256	105/9376	2.79047619047619	ITGA6/ADRB1/ITGB4/DAG1/ITGAV/TPM1/ITGB1/SGCE	3.09106480943723
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	15/256	275/9376	1.99772727272727	MT-CO3/MT-CO1/LAMC1/HSPA5/MT-ND4/MT-ND4L/MT-CO2/MT-ND5/MT-ND2/MT-ATP8/MT-ND1/EGR1/MT-ATP6/MT-CYB/PIK3CB	2.8134670623828
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/256	87/9376	2.94683908045977	EGFR/FOS/TGFBR1/GADD45G/TCF7L2/PIK3CB/GADD45A	3.05642259894174
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	16/256	308/9376	1.9025974025974	MT-CO3/MT-CO1/GPX3/MT-ND4/MT-ND4L/MT-CO2/MT-ND5/MT-ND2/MT-ATP8/MT-ND1/MT-ATP6/AP2A2/CLTC/MT-CYB/WIPI2/GPX8	2.69849665234681
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	8/256	110/9376	2.66363636363636	FBN1/ID1/TFRC/ID4/TGFBR1/LTBP1/NCOR1/BMP7	2.94047032510581
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/256	157/9376	2.3328025477707	ID1/DVL3/CDH1/RASSF6/TEAD1/TGFBR1/AMOT/TCF7L2/BMP7/WNT5A	2.82151221428294
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/256	160/9376	2.2890625	ITGA6/CLDN4/PTPRF/ITGAV/GLG1/CD99/CDH1/CADM1/NRCAM/ITGB1	2.75531295725994
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/256	71/9376	3.09507042253521	EGFR/SLC2A1/MET/IDH2/PIK3CB/SLC1A5	2.96877861500178
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/256	116/9376	2.52586206896552	CLDN4/CD99/THY1/ACTN4/EZR/ITGB1/PIK3CB/VAV3	2.77042871595253
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/256	19/9376	5.78289473684211	HEXB/GLB1/HEXA	3.49629050157556
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/256	73/9376	3.01027397260274	EGFR/MET/CDH1/GADD45G/PIK3CB/GADD45A	2.888772699217
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	14/256	268/9376	1.91324626865672	MT-CO3/DUSP1/MT-CO1/HSPA5/MT-ND4/MT-ND4L/MT-CO2/MT-ND5/MT-ND2/MT-ATP8/MT-ND1/SLC39A7/MT-ATP6/MT-CYB	2.54127693161862
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/256	55/9376	3.32954545454545	HEXB/GLB1/HEXA/SGPP1/GM2A	2.90288266116142
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/256	37/9376	3.95945945945946	CDH1/GADD45G/TCF7L2/GADD45A	3.02183864659391
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	6/256	77/9376	2.8538961038961	EGFR/RALBP1/TGFBR1/GADD45G/PIK3CB/GADD45A	2.73665992270416
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/256	38/9376	3.85526315789474	HEXB/HEXA/UXS1/PMM2	2.95473955960601
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/256	100/9376	2.56375	CSF3R/ITGA6/CD55/TFRC/CSF2RA/CD59/MME	2.6338749654314
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/256	148/9376	2.22719594594595	EGFR/FOS/DVL3/GADD45G/TCF7L2/PIK3CB/WNT5A/LRP5/GADD45A	2.52115286113479
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	17/256	362/9376	1.71995856353591	CSF3R/EGFR/FLT1/HSP90B1/ITGA6/LAMC1/FN1/LAMA5/LAMB1/ITGB4/IGF2/MET/ITGAV/PRL/ITGB1/ERBB3/PIK3CB	2.34051383094896
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/256	103/9376	2.48907766990291	DPP4/ATP1B3/COL14A1/KCNN4/MME/ATP1A1/SLC1A5	2.54585717214823
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/256	41/9376	3.57317073170732	EGFR/CDH1/DAPK1/RPS6KA5	2.76637831636143
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/256	61/9376	3.00204918032787	ATP1B3/SLC40A1/ATP2B4/ATP2B1/ATP1A1	2.62818801978746
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	5/256	63/9376	2.90674603174603	DVL3/GADD45G/TCF7L2/WNT5A/GADD45A	2.54405517609371
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/256	133/9376	2.20300751879699	EGFR/TNFSF10/TGFBR1/GADD45G/ATG12/PIK3CB/HOMER1/GADD45A	2.34097021121428
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/256	43/9376	3.40697674418605	ECI2/ACSL3/ACADVL/ACOX1	2.6503528132209
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/256	110/9376	2.33068181818182	EGFR/FLT1/SLC2A1/TFRC/EPAS1/PIK3CB/EDN1	2.35197455648832
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/256	44/9376	3.32954545454545	HEXB/TUSC3/HEXA/RPN1	2.59488648305503
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/256	115/9376	2.22934782608696	EGFR/FOS/GNA12/EGR1/GATA3/LRP5/JUND	2.22230138713595
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	20/256	480/9376	1.52604166666667	MT-CO3/APP/MT-CO1/GPX3/HSPA5/MT-ND4/MT-ND4L/ATXN2/MT-CO2/MT-ND5/DVL3/MT-ND2/MT-ATP8/MT-ND1/MT-ATP6/MT-CYB/WNT5A/LRP5/WIPI2/GPX8	1.98221874308536
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	15/256	333/9376	1.64977477477477	EGFR/ITGA6/LAMC1/FN1/LAMA5/LAMB1/ITGB4/DVL3/ITGAV/ITGB1/ATP6V1B1/TCF7L2/PIK3CB/IRF3/WNT5A	2.02272527113228
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/256	12/9376	6.10416666666667	CD46/NPC1	2.9641008041426
NA	NA	hsa03272	Virion - Hepatitis viruses	4/256	48/9376	3.05208333333333	EGFR/CLDN4/DPP4/LAMP2	2.38797372981263
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/256	93/9376	2.36290322580645	ADRB1/ATP1B3/ATP2B4/ATP2B1/KCNN4/ATP1A1	2.21294449035896
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	12/256	253/9376	1.73715415019763	EGFR/ACTN4/ATG12/WASF2/ITGB1/DIAPH1/PIK3CB/IRF3/RRAGA/RPS6KA5/CAST/WIPI2	1.9913974185507
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	16/256	368/9376	1.59239130434783	MT-CO3/MT-CO1/GPX3/HSPA5/MT-ND4/MT-ND4L/ATXN2/MT-CO2/MT-ND5/MT-ND2/MT-ATP8/MT-ND1/MT-ATP6/MT-CYB/WIPI2/GPX8	1.94234600738513
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	5/256	73/9376	2.50856164383562	EGFR/MET/GADD45G/PIK3CB/GADD45A	2.16780983646523
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	7/256	122/9376	2.10143442622951	SLC2A1/ITGAV/DIO2/ATP1B3/NCOR1/PIK3CB/ATP1A1	2.05154957511007
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/256	31/9376	3.54435483870968	ACSS1/GCSH/GLDC	2.37726214150602
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/256	178/9376	1.85182584269663	DVL3/LGR5/NOTUM/TCF7L2/WNT5A/LRP5/ZNRF3/LGR4/TLE1	1.92230507183465
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/256	101/9376	2.17574257425743	FN1/EGR1/TGFBR1/DIAPH1/PIK3CB/EDN1	1.99032580587596
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	6/256	103/9376	2.13349514563107	LAMC1/FN1/LAMA5/LAMB1/ACTN4/PIK3CB	1.93792224839971
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	8/256	157/9376	1.86624203821656	SLC2A1/CALR/ITGAV/ADAM9/CD47/TMEM30A/ANO6/LRP1	1.83381439016717
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/256	56/9376	2.61607142857143	TUSC3/MOGS/RPN1/GANAB	2.0321455531201
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	13/256	300/9376	1.58708333333333	EGFR/FLT1/DUSP1/FOS/IGF2/MET/GNA12/TGFBR1/GADD45G/ERBB3/RPS6KA5/JUND/GADD45A	1.73149537898838
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/256	16/9376	4.578125	HEXB/HEXA	2.39985928096468
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/256	106/9376	2.07311320754717	EGFR/HSP90B1/SPINT1/TCF7L2/FOLR1/PIK3CB	1.86151614539812
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/256	137/9376	1.8713503649635	CTSL/TNFSF10/CTSV/FOS/GADD45G/PIK3CB/GADD45A	1.72126928519207
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/256	138/9376	1.85778985507246	FN1/FOS/WASF2/ITGB1/PIK3CB/IRF3/VAV3	1.70074683544162
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/256	38/9376	2.89144736842105	ATP1B3/PIK3CB/ATP1A1	1.9573447543473
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/256	62/9376	2.36290322580645	DVL3/APH1A/NCSTN/TLE1	1.80385219451055
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/256	226/9376	1.62057522123894	ADRB1/FOS/ATP1B3/ATP2B4/ATP2B1/PIK3CB/EDN1/ATP1A1/ACOX1/VAV3	1.58214507986669
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	8/256	169/9376	1.73372781065089	CTSL/EIF2AK4/LAMP2/ATG12/DAPK1/PIK3CB/RRAGA/WIPI2	1.61260299839977
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	5/256	88/9376	2.08096590909091	F5/CD55/CD46/CD59/CLU	1.7068699478844
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/256	19/9376	3.85526315789474	GCSH/GLDC	2.08719405458568
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/256	142/9376	1.80545774647887	CTSL/DUSP1/HSP90B1/FOS/ITGAV/PIK3CB/EDN1	1.62031779439704
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	7/256	144/9376	1.78038194444444	ID1/IL6ST/DVL3/ID4/DLX5/PIK3CB/WNT5A	1.58106149660583
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/256	42/9376	2.61607142857143	TFRC/SLC40A1/ACSL3	1.758569354938
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/256	70/9376	2.09285714285714	SLC2A1/MET/EPAS1/PIK3CB	1.53758485547803
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/256	154/9376	1.66477272727273	ADRB1/ATP1B3/ATP2B4/ATP2B1/TPM1/RPS6KA5/ATP1A1	1.39357131107696
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/256	23/9376	3.18478260869565	ATP1B3/ATP1A1	1.75753864289288
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/256	184/9376	1.59239130434783	SEMA6A/MET/NRP1/ITGB1/BMP7/PIK3CB/WNT5A/EPHB4	1.35963013035526
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/256	158/9376	1.62262658227848	DVL3/SLC38A9/ATP6V1B1/PIK3CB/RRAGA/WNT5A/LRP5	1.32234887989233
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/256	48/9376	2.2890625	ATP1B3/PIK3CB/ATP1A1	1.50005963992037
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/256	76/9376	1.92763157894737	EGFR/GADD45G/PIK3CB/GADD45A	1.36034494855334
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/256	26/9376	2.81730769230769	SLC5A6/SLC19A3	1.55459596130767
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	4/256	77/9376	1.9025974025974	TGFBR1/GADD45G/PIK3CB/GADD45A	1.33238434065106
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/256	51/9376	2.15441176470588	KDELR2/KDELR1/ATP6V1B1	1.38493571007472
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/256	166/9376	1.54442771084337	ADRB1/GNA12/ATP1B3/ATP2B4/ATP2B1/GTF2I/ATP1A1	1.18569408374999
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	3/256	52/9376	2.11298076923077	LRP2/NPC1/LRP1	1.3483306330564
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/256	80/9376	1.83125	EGFR/MET/ERBB3/PIK3CB	1.25094091093489
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	8/256	200/9376	1.465	TNFSF10/CLDN4/FOS/GNA12/EZR/WASF2/MYO5B/ITGB1	1.11365186824318
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	7/256	170/9376	1.50808823529412	CLDN4/ACTN4/EZR/MPDZ/AMOT/ITGB1/SYNPO	1.12004717784866
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/256	82/9376	1.78658536585366	CTSL/HSPA5/CALR/PDIA3	1.1985596587156
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/256	29/9376	2.52586206896552	RASSF6/TEAD1	1.37875263811481
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/256	83/9376	1.76506024096386	IDH2/ECI2/ACSL3/ACOX1	1.17291060283081
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	5/256	112/9376	1.63504464285714	ITGA6/LAMC1/LAMA5/LAMB1/ITGB1	1.13271902928529
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	6/256	142/9376	1.54753521126761	FOS/TGFBR1/FHL2/PIK3CB/JUND/FOSB	1.10146193236608
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	3/256	57/9376	1.92763157894737	ACSL3/ACADVL/ACOX1	1.1768916955637
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/256	31/9376	2.36290322580645	HSPA5/SEC62	1.27339873823936
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/256	86/9376	1.70348837209302	SLC2A1/ATP1B3/KCNN4/ATP1A1	1.09801050137016
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	5/256	116/9376	1.57866379310345	ACSS1/IDH2/GCSH/ACOX1/GLDC	1.05064987321081
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/256	32/9376	2.2890625	GLB1/GAA	1.22374449327095
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/256	32/9376	2.2890625	ACSS1/ACOX1	1.22374449327095
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	2/256	32/9376	2.2890625	ATG12/WIPI2	1.22374449327095
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/256	59/9376	1.86228813559322	GPX3/IDH2/GPX8	1.11313687615849
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/256	149/9376	1.4748322147651	MT-ND4/MT-ND4L/MT-ND5/GABRE/MT-ND2/MT-ND1	0.978838970033659
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/256	212/9376	1.38207547169811	EGFR/FLT1/ID1/MET/CDH1/ITGB1/PIK3CB/VAV3	0.94272006299497
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	8/256	216/9376	1.35648148148148	HSP90B1/TNFSF10/HSPA5/CYP2J2/FOS/PIK3CB/IRF3/VAV3	0.888023204890818
NA	NA	hsa04382	Cornified envelope formation	8/256	217/9376	1.35023041474654	ITGA6/LAMA5/DSG2/CLDN4/ITGB4/DSP/KRT19/DST	0.874516277624873
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	9/256	250/9376	1.3185	EGFR/TFRC/EEA1/SH3GLB2/RAB11FIP1/TGFBR1/AP2A2/CLTC/FOLR1	0.855160062762211
NA	NA	hsa04081	Hormone signaling	8/256	219/9376	1.337899543379	ADRB1/IGF2/GNA12/ITGAV/DIO2/SLC40A1/PRL/PIK3CB	0.847698192056808
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/256	94/9376	1.55851063829787	HSP90B1/FOS/JUND/FOSB	0.91176474674576
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/256	36/9376	2.03472222222222	GALNT11/GALNT1	1.04210094632594
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/256	157/9376	1.39968152866242	MT-CO3/MT-CO1/FOS/MT-CO2/MT-CYB/PIK3CB	0.846116566051394
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/256	254/9376	1.29773622047244	EGFR/FLT1/ADRB1/P2RX4/MET/ASPH/ATP2B4/ATP2B1/ERBB3	0.805956676090305
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/256	95/9376	1.54210526315789	CTSL/FLT1/FOS/ATP6V1B1	0.88972591771932
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	2/256	37/9376	1.97972972972973	UXS1/PMM2	1.00038037387241
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/256	98/9376	1.49489795918367	WASF2/SCIN/PIK3CB/VAV3	0.825105948950403
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/256	98/9376	1.49489795918367	ATP1B3/ATP2B4/ATP2B1/ATP1A1	0.825105948950403
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	5/256	130/9376	1.40865384615385	EGFR/FOS/TGFBR1/PIK3CB/EDN1	0.78606511683972
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	4/256	99/9376	1.47979797979798	EGFR/FOS/NCOR1/PIK3CB	0.804045148339683
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/256	99/9376	1.47979797979798	EGFR/FOS/WASF2/PIK3CB	0.804045148339683
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/256	39/9376	1.87820512820513	GCSH/GLDC	0.920731061456804
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/256	101/9376	1.45049504950495	DVL3/TCF7L2/WNT5A/EDN1	0.762609045619842
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/256	70/9376	1.56964285714286	CD55/DAG1/SGCE	0.801453543950152
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/256	102/9376	1.43627450980392	ATP1B3/ATP2B4/ATP2B1/ATP1A1	0.742223295451778
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/256	71/9376	1.54753521126761	FOS/PRL/PIK3CB	0.775874075013071
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/256	71/9376	1.54753521126761	EGFR/MET/ATP6V1B1	0.775874075013071
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/256	41/9376	1.78658536585366	GCSH/GLDC	0.845646452157877
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/256	103/9376	1.42233009708738	FOS/CALR/TGFBR1/PIK3CB	0.722052400902677
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/256	201/9376	1.27549751243781	IGFBP3/FLT1/SPINT1/MET/GADD45G/NCOR1/GADD45A	0.661486333171747
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/256	168/9376	1.30803571428571	CSF3R/EGFR/IL6ST/CSF2RA/PRL/PIK3CB	0.674965009904235
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/256	72/9376	1.52604166666667	ADAR/ATG12/IRF3	0.750688467647758
Human Diseases	Infectious disease: viral	hsa05162	Measles	5/256	136/9376	1.34650735294118	FOS/ADAR/CD46/PIK3CB/IRF3	0.681952498885171
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/256	14/9376	2.61607142857143	B3GNT2	1.01379105114289
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	8/256	238/9376	1.23109243697479	RPS4Y1/EGFR/FOS/IL6ST/ADAR/NRP1/PIK3CB/IRF3	0.605002035472272
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/256	139/9376	1.31744604316547	EGFR/HSP90B1/FOS/KRT19/PIK3CB	0.631713340125105
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/256	75/9376	1.465	IGFBP3/GADD45G/GADD45A	0.67737156874727
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/256	76/9376	1.44572368421053	ATP1B3/EZR/ATP1A1	0.653640923861624
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	4/256	109/9376	1.34403669724771	FOS/IL6ST/GATA3/TGFBR1	0.605280439004153
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/256	78/9376	1.40865384615385	FOS/ITGB1/IRF3	0.607178413230061
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	8/256	248/9376	1.18145161290323	HSP90B1/TNFSF10/AHNAK/FOS/TCF7L2/PIK3CB/RHOB/DYNC1LI2	0.485184657711058
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/256	79/9376	1.39082278481013	AP2A2/ATP6V1B1/CLTC	0.584426912658796
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/256	17/9376	2.15441176470588	CDO1	0.798139276095347
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/256	49/9376	1.49489795918367	GALNT11/GALNT1	0.581903428802991
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/256	18/9376	2.03472222222222	ACSL3	0.736167618047138
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/256	117/9376	1.25213675213675	SMARCA1/BRD8/SMARCA2/SMARCC1	0.459785472159196
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/256	50/9376	1.465	MET/LRP1	0.552329769128853
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/256	119/9376	1.23109243697479	FOS/PIK3CB/RPS6KA5/EDN1	0.425042427218041
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	7/256	224/9376	1.14453125	SLC2A1/FOS/CALR/EGR1/TGFBR1/NRP1/PIK3CB	0.366805605483042
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/256	86/9376	1.27761627906977	EGFR/ERBB3/PIK3CB	0.433305797028305
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/256	20/9376	1.83125	CYB5R1	0.623461659607411
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	7/256	227/9376	1.12940528634361	EGFR/CALR/GNA12/ITGAV/PDIA3/PIK3CB/IRF3	0.330663558042324
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	5/256	157/9376	1.16640127388535	IGFBP3/TGFBR1/GADD45G/PIK3CB/GADD45A	0.352267653993509
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/256	89/9376	1.23455056179775	EGFR/ADRB1/GJA1	0.372479143292092
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/256	21/9376	1.74404761904762	CHPF	0.571869170612696
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/256	125/9376	1.172	GNA12/ORMDL1/SGPP1/PIK3CB	0.324337611865029
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/256	90/9376	1.22083333333333	SLC2A1/ATP1B3/ATP1A1	0.352679116881053
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/256	90/9376	1.22083333333333	EGFR/FOS/PIK3CB	0.352679116881053
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/256	91/9376	1.20741758241758	FOS/PIK3CB/VAV3	0.333106810262697
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/256	23/9376	1.59239130434783	MME	0.476546547451055
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/256	59/9376	1.24152542372881	ADRB1/PIK3CB	0.311787724525967
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/256	24/9376	1.52604166666667	EXTL2	0.432296499181746
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	6/256	205/9376	1.0719512195122	CALR/PDIA3/GADD45G/PIK3CB/IRF3/GADD45A	0.174507840705743
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	4/256	134/9376	1.09328358208955	GNA12/ADM/EDN1/PPP1R12B	0.182214457942978
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/256	26/9376	1.40865384615385	ACOX1	0.349578456907809
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/256	63/9376	1.16269841269841	SMYD2/SETD2	0.217078589427351
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/256	27/9376	1.35648148148148	ACOX1	0.310773857050987
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/256	65/9376	1.12692307692308	KCNN4/PIK3CB	0.172031235584554
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/256	28/9376	1.30803571428571	B3GNT2	0.273482120042103
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/256	28/9376	1.30803571428571	ATP6V1B1	0.273482120042103
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	5/256	180/9376	1.01736111111111	SRSF5/CALR/PDIA3/PIK3CB/IRF3	0.0394023831261011
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/256	144/9376	1.01736111111111	ACADVL/TCF7L2/IRF3/ACOX1	0.0351737819044678
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/256	68/9376	1.07720588235294	TCF7L2/PIK3CB	0.107049553803227
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/256	30/9376	1.22083333333333	IDH2	0.20296472683656
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/256	30/9376	1.22083333333333	PIGT	0.20296472683656
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/256	30/9376	1.22083333333333	CYP2J2	0.20296472683656
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/256	30/9376	1.22083333333333	FOLR1	0.20296472683656
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/256	69/9376	1.06159420289855	PIK3CB/VAV3	0.0860335273899446
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/256	69/9376	1.06159420289855	ADRB1/EDN1	0.0860335273899446
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/256	69/9376	1.06159420289855	FOS/FOSB	0.0860335273899446
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	8/256	298/9376	0.983221476510067	CSF3R/TNFSF10/IL6ST/TGFBR1/CSF2RA/PRL/IL1RL1/BMP7	-0.0493145398130244
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/256	70/9376	1.04642857142857	SLC2A1/ACSL3	0.0653222324222694
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/256	109/9376	1.00802752293578	FOS/PIK3CB/IRF3	0.0141232102434303
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/256	109/9376	1.00802752293578	SLC2A1/PTPRF/PIK3CB	0.0141232102434303
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/256	31/9376	1.18145161290323	ACOX1	0.169535334972696
NA	NA	hsa04981	Folate transport and metabolism	1/256	31/9376	1.18145161290323	FOLR1	0.169535334972696
Human Diseases	Immune disease	hsa05310	Asthma	1/256	32/9376	1.14453125	PRG2	0.137207715912197
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/256	33/9376	1.10984848484848	IDH2	0.105904903355165
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/256	33/9376	1.10984848484848	STX16	0.105904903355165
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	4/256	154/9376	0.951298701298701	NME3/QPRT/PMM2/RFK	-0.102093136342635
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/256	34/9376	1.07720588235294	BHLHE40	0.075557593881356
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/256	115/9376	0.955434782608696	DUSP1/APP/CYP2J2	-0.0805608814081115
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	4/256	155/9376	0.945161290322581	EGFR/DVL3/TCF7L2/WNT5A	-0.115337960424694
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/256	76/9376	0.963815789473684	ACSL3/ACOX1	-0.0530631008300948
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/256	156/9376	0.939102564102564	EGFR/CLDN4/PIK3CB/IRF3	-0.128500272096233
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/256	35/9376	1.04642857142857	PMM2	0.0461031775153532
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/256	196/9376	0.934311224489796	FOS/IL6ST/TCF7L2/PIK3CB/IRF3	-0.155706256368795
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/256	158/9376	0.927215189873418	CDKN1C/GADD45G/STAG1/GADD45A	-0.154582079987413
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/256	36/9376	1.01736111111111	GAA	0.0174849152068111
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/256	78/9376	0.939102564102564	FOS/ITGB1	-0.0904814890303621
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	6/256	238/9376	0.923319327731092	EGFR/FLT1/IGF2/MET/RALBP1/PIK3CB	-0.200750675406708
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/256	120/9376	0.915625	MAGED1/PIK3CB/RPS6KA5	-0.15584789386645
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/256	37/9376	0.989864864864865	APOL1	-0.0103487624883352
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/256	38/9376	0.963815789473684	QPRT	-0.0374448561701221
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/256	122/9376	0.900614754098361	FOS/PIK3CB/VAV3	-0.185116566312258
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/256	122/9376	0.900614754098361	IGFBP3/FOS/PIK3CB	-0.185116566312258
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	4/256	163/9376	0.898773006134969	FOS/TGFBR1/PIK3CB/IRF3	-0.218422718534736
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/256	323/9376	0.907120743034056	TIMP3/EGFR/MET/EZR/TPM1/ERBB3/PIK3CB/RPS6KA5	-0.284598059821359
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/256	205/9376	0.893292682926829	IL6ST/ACTN4/SCIN/PIK3CB/IRF3	-0.258804001046653
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/256	83/9376	0.882530120481928	ADAR/IRF3	-0.180092572875597
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/256	41/9376	0.893292682926829	GABRE	-0.114719479943898
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/256	214/9376	0.855724299065421	FOS/CALR/PDIA3/PIK3CB/IRF3	-0.357695220822235
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/256	173/9376	0.846820809248555	TNFSF10/ADAR/PIK3CB/IRF3	-0.340695433888784
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/256	89/9376	0.823033707865168	GABRE/SLC38A1	-0.281032167992836
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/256	44/9376	0.832386363636364	GTF2I	-0.186705246951521
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/256	44/9376	0.832386363636364	DYNC1LI2	-0.186705246951521
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/256	133/9376	0.826127819548872	TNFSF10/PIK3CB/VAV3	-0.338343350839564
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/256	217/9376	0.84389400921659	EGFR/HSP90B1/ADRB1/FOS/PIK3CB	-0.389792617165034
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/256	93/9376	0.787634408602151	FOS/GATA3	-0.34481778054903
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/256	93/9376	0.787634408602151	EGFR/EGR1	-0.34481778054903
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/256	47/9376	0.779255319148936	ACSS1	-0.254173243841618
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/256	47/9376	0.779255319148936	PIK3CB	-0.254173243841618
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/256	140/9376	0.784821428571429	CDH1/EGR1/TGFBR1	-0.429763252023903
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/256	49/9376	0.747448979591837	FOSB	-0.296950718822145
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/256	97/9376	0.755154639175258	FOS/RPS6KA5	-0.406102217704816
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/256	99/9376	0.73989898989899	CYP2J2/PIK3CB	-0.435877106731512
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/256	144/9376	0.763020833333333	ATXN2/PIK3CB/WIPI2	-0.480122122995985
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	2/256	100/9376	0.7325	TNFSF10/IL6ST	-0.450558946924316
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/256	52/9376	0.704326923076923	CYP2J2	-0.358195826924269
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/256	54/9376	0.678240740740741	CDO1	-0.397266172135381
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/256	149/9376	0.73741610738255	EGFR/GNA12/PIK3CB	-0.541301409223561
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/256	105/9376	0.697619047619048	GADD45G/GADD45A	-0.522028232444851
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/256	56/9376	0.654017857142857	LRP2	-0.435058785543668
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/256	154/9376	0.713474025974026	EGFR/FOS/PPP1R12B	-0.600647952149166
NA	NA	hsa04082	Neuroactive ligand signaling	4/256	199/9376	0.736180904522613	TAC3/ADRB1/P2RX4/GABRE	-0.630217706732173
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/256	59/9376	0.620762711864407	NME3	-0.489561427106562
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	1/256	60/9376	0.610416666666667	PIK3CB	-0.507188568117565
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/256	60/9376	0.610416666666667	GNA12	-0.507188568117565
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/256	62/9376	0.590725806451613	PIK3CB	-0.541689342434381
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/256	63/9376	0.581349206349206	CYP2J2	-0.558580272794769
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/256	115/9376	0.63695652173913	FOS/PIK3CB	-0.656276448544128
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/256	116/9376	0.631465517241379	SLC38A1/HOMER1	-0.669128969530908
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/256	66/9376	0.554924242424242	STS	-0.607909973695241
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/256	66/9376	0.554924242424242	GATA3	-0.607909973695241
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/256	67/9376	0.546641791044776	ACSS1	-0.623929574432692
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/256	122/9376	0.600409836065574	PIK3CB/RAB2A	-0.74428310166784
Organismal Systems	Immune system	hsa04611	Platelet activation	2/256	126/9376	0.581349206349206	ITGB1/PIK3CB	-0.792637338662753
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/256	75/9376	0.488333333333333	IDH2	-0.745351511130508
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/256	75/9376	0.488333333333333	PIK3CB	-0.745351511130508
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/256	181/9376	0.607044198895028	PLA2R1/EEA1/LAMP2	-0.894366094833571
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/256	370/9376	0.692905405405405	TAC3/ADRB1/P2RX4/GABRE/ADM/PRL/EDN1	-1.00975326140816
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/256	78/9376	0.469551282051282	PIK3CB	-0.788141391290785
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/256	78/9376	0.469551282051282	BTG1	-0.788141391290785
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	2/256	138/9376	0.530797101449275	PTPRF/PIK3CB	-0.930292355605871
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/256	82/9376	0.446646341463415	NME3	-0.843172783166209
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/256	194/9376	0.566365979381443	MYO5B/TPM1/DYNC1LI2	-1.0225010666917
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/256	85/9376	0.430882352941176	NME3	-0.883056490219517
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/256	90/9376	0.406944444444444	PIK3CB	-0.947131967976162
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/256	91/9376	0.402472527472527	GABRE	-0.959612334200484
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/256	98/9376	0.373724489795918	PIK3CB	-1.0441418065326
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/256	99/9376	0.369949494949495	KRT19	-1.05583823426711
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/256	103/9376	0.355582524271845	PNN	-1.10175237034288
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/256	104/9376	0.352163461538462	PTDSS1	-1.11302161576083
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/256	105/9376	0.348809523809524	CITED2	-1.12421040609186
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/256	105/9376	0.348809523809524	PIK3CB	-1.12421040609186
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/256	107/9376	0.342289719626168	SLC2A1	-1.14635275655017
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/256	108/9376	0.33912037037037	PNN	-1.15730927219852
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/256	110/9376	0.332954545454545	PIK3CB	-1.1790000552166
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	2/256	187/9376	0.391711229946524	ATG12/IRF3	-1.40768239108729
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/256	191/9376	0.383507853403141	SLC29A1/FOSB	-1.44215803356117
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	2/256	193/9376	0.379533678756477	PIK3CB/VAV3	-1.45919313275654
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/256	128/9376	0.2861328125	NME3	-1.36240646652789
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/256	133/9376	0.275375939849624	FOS	-1.4100687756611
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	1/256	142/9376	0.257922535211268	UBE2H	-1.49281737778875
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/256	143/9376	0.256118881118881	ACTN4	-1.50178699194309
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/256	168/9376	0.218005952380952	TNFSF10	-1.71349812900809
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/256	243/9376	0.301440329218107	SRSF5/SF3B1	-1.84845175136559
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/256	195/9376	0.187820512820513	PIK3CB	-1.9201383877828
Genetic Information Processing	Translation	hsa03010	Ribosome	1/256	222/9376	0.164977477477477	RPS4Y1	-2.10948977413452