category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	35/460	174/9376	4.09995002498751	HSPA5/XBP1/HSP90B1/SSR4/P4HB/PDIA6/TUSC3/RPN1/PDIA3/OS9/RRBP1/LMAN2/SEC61G/CRYAB/TRAM1/DDOST/OSTC/DNAJC1/STT3A/ERLEC1/SEC62/UBQLN2/SSR3/UBE2D3/RPN2/UBE2D2/SIL1/ERP29/DNAJC3/EDEM3/AMFR/CANX/SEC31A/MOGS/STUB1	9.37492336616131
NA	NA	hsa04518	Integrin signaling	27/460	154/9376	3.57357425183512	FLT1/FN1/FBN1/ACTB/PARVA/LAMA5/ITGA6/ERBB2/LAMB2/TGFB1/ITGA1/PGF/FLNA/PXN/ACTN4/ITGB1/FERMT2/COL4A2/EGFR/FGB/CDH1/PIK3CB/VEGFA/TNXB/ITGB4/LAMC1/FGG	7.31415279230028
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	29/460	203/9376	2.91180124223602	FLT1/FN1/ACTB/PARVA/LAMA5/ITGA6/ERBB2/LAMB2/ITGA1/CAV2/ZYX/PGF/VASP/BAD/FLNA/PXN/ACTN4/ITGB1/COL4A2/EGFR/PIK3CB/VEGFA/TNXB/PPP1CC/ITGB4/RAF1/LAMC1/RAP1B/PPP1R12B	6.25481668224411
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	25/460	169/9376	3.01517880113198	CTSL/MAP1LC3A/UBC/BNIP3/EIF2AK4/ATG9B/LAMP1/MAP1LC3B/VMP1/PPP2CA/BAD/RRAGA/WIPI1/AKT1S1/LAMP2/SNAP29/GORASP2/PIK3CB/RHEB/TANK/WDFY3/RAF1/DAPK1/DAPK3/RRAS	6.00450748834887
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	27/460	204/9376	2.69769820971867	TIMP3/FN1/CTSL/IGF2/ACTB/LUM/WNT5A/WNT4/HSPG2/CD63/FGFR1/WNT16/ERBB2/TGFB1/CAV2/FLNA/PXN/ITGB1/EGFR/PIK3CB/VEGFA/EZR/PPP1CC/GPC1/RAF1/PPP1R12B/RRAS	5.56830577015771
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	11/460	44/9376	5.09565217391304	HEXB/TUSC3/RPN1/HEXA/ALG2/DDOST/OSTC/STT3A/MGAT2/RPN2/MGAT1	6.18502649106229
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	27/460	233/9376	2.36193319649188	FN1/FBLN1/FBN1/ACTB/BGN/TPM1/PDLIM2/HSPG2/INF2/PDLIM4/ITGA6/DSG2/ITGA1/COL5A2/ZYX/DAG1/SPTBN1/ITGB1/COL4A2/ATP1A1/ATP1A4/SGCB/FHL2/SPTAN1/EMD/ITGB4/ATP1B3	4.78155252137748
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	28/460	250/9376	2.28285217391304	HEXB/CTSL/CLTB/ATP6V0E1/GNPTG/CLN5/HEXA/CD63/LAMP1/CTSV/GAA/RRAGA/OSTM1/NEU1/AKT1S1/LAMP2/FUCA2/AP3S1/CTSF/SNAP29/CTBS/FUCA1/SLC38A9/VPS13A/CD164/ASAH1/AGA/LAPTM4A	4.66966699101774
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	11/460	56/9376	4.00372670807453	TUSC3/RPN1/ALG2/DDOST/OSTC/STT3A/MGAT2/RPN2/MGAT1/MGAT5/MOGS	5.12066067182146
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	37/460	388/9376	1.94370237561632	MT-CO2/MT-CO3/MT-CO1/MT-ND4/XBP1/MT-ND5/MT-ATP6/MT-ND4L/WNT5A/WNT4/MT-CYB/MT-ATP8/DKK1/TUBA3E/COX7A1/RTN3/MT-ND1/SLC39A7/MT-ND2/RTN4/APP/WNT16/DVL3/BAD/WIPI1/CSNK1E/TUBB2A/CYC1/PIK3CB/PSMD3/COX6A1/PSENEN/NCSTN/BACE2/ATP2A2/RAF1/EIF2AK2	4.31220008077355
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	6/460	18/9376	6.79420289855072	HEXB/HEXA/NEU1/FUCA2/FUCA1/AGA	5.5887921116469
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/460	87/9376	3.04567716141929	MT-CO2/MT-CO3/MT-CO1/MT-CYB/TPM1/COX7A1/ATP1A1/CYC1/ASPH/ATP1A4/COX6A1/ATP2A2/ATP1B3	4.35403349410452
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/460	89/9376	2.97723497801661	FN1/HSPG2/LAMA5/ITGA6/LAMB2/ITGA1/DAG1/ITGB1/COL4A2/TNXB/CD47/ITGB4/LAMC1	4.25691608691251
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	31/460	333/9376	1.89748008878444	HLA-C/FN1/HLA-G/WNT5A/WNT4/ATP6V0E1/LAMA5/ISG15/ITGA6/WNT16/PPP2CA/LAMB2/ITGA1/DVL3/BAD/PXN/ITGB1/COL4A2/TRADD/EGFR/PIK3CB/VEGFA/TNXB/RHEB/JAK1/ITGB4/IRF3/RAF1/LAMC1/MX1/EIF2AK2	3.78765311137437
NA	NA	hsa03272	Virion - Hepatitis viruses	9/460	48/9376	3.82173913043478	HSPG2/CD63/LAMP1/SCARB1/CLDN4/EGFR/LAMP2/DPP4/LDLR	4.45166766363482
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	32/460	362/9376	1.80177756425655	PRL/FLT1/FN1/IGF2/HSP90B1/PRLR/LAMA5/FGFR1/ITGA6/PPP2CA/ERBB2/LAMB2/ITGA1/F2R/PGF/BAD/ITGB1/COL4A2/EGFR/YWHAQ/EPOR/PIK3CB/VEGFA/TNXB/RHEB/JAK1/YWHAH/ITGB4/CSF3R/IL2RB/RAF1/LAMC1	3.53369394203911
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	14/460	110/9376	2.59415019762846	FLT1/EGLN3/EPAS1/LDHA/SLC2A1/ALDOA/TFRC/ERBB2/IFNGR2/ALDOC/EGFR/PIK3CB/VEGFA/PGK1	3.81996123863724
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/460	232/9376	2.02068965517241	RGCC/FN1/ACTB/PFN1/GSN/FGFR1/ITGA6/ITGA1/F2R/PXN/ACTN4/ITGB1/EGFR/WASF2/PIK3CB/EZR/PPP1CC/GNA12/ITGB4/C7/RAF1/PPP1R12B/RRAS	3.57560158440523
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/460	77/9376	2.91180124223602	RALBP1/ERBB2/TGFB1/GADD45G/BAD/GADD45A/EGFR/PIK3CB/VEGFA/JAK1/RAF1	3.82603996659707
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	22/460	227/9376	1.97540701015131	MT-CO2/MT-CO3/MT-CO1/MT-ND4/MT-ND5/MT-ATP6/MT-ND4L/GSTA1/MT-CYB/MT-ATP8/COX7A1/FOS/MT-ND1/MT-ND2/SLC26A2/BAD/EGFR/CYC1/PIK3CB/VEGFA/COX6A1/RAF1	3.37902582848221
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/460	144/9376	2.26473429951691	IL6ST/WNT5A/WNT4/ID3/FGFR1/ID1/WNT16/DVL3/KLF4/ID4/PIK3CB/MEIS1/DLX5/JAK1/RAF1/LEFTY2	3.47385885672625
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	8/460	50/9376	3.26121739130435	P4HA2/MAOB/OAT/AOC1/P4HA1/SMOX/P4HA3/MAOA	3.64132244200366
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/460	86/9376	2.60707785642063	ACTB/GJA1/ITGA6/DSG2/ITGA1/DAG1/ITGB1/SGCB/EMD/ITGB4/ATP2A2	3.40061769123539
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/460	138/9376	2.21550094517958	MT-CO2/MT-CO3/MT-CO1/MT-ND4/MT-ND5/MT-ATP6/MT-ND4L/MT-CYB/ATP6V0E1/MT-ATP8/COX7A1/MT-ND1/MT-ND2/CYC1/COX6A1	3.2672727397328
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	24/460	268/9376	1.82530824140169	MT-CO2/MT-CO3/MT-CO1/MT-ND4/HSPA5/XBP1/MT-ND5/MT-ATP6/DUSP1/MT-ND4L/MT-CYB/MT-ATP8/TUBA3E/UBC/COX7A1/MT-ND1/SLC39A7/MT-ND2/MAOB/TUBB2A/CYC1/PSMD3/COX6A1/MAOA	3.11351951471458
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/460	41/9376	3.47995758218452	ERBB2/EGFR/CDH1/VEGFA/RAF1/DAPK1/DAPK3	3.61458584859977
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	11/460	88/9376	2.54782608695652	CD59/SERPINB2/CFD/SERPINE2/CD46/PROCR/F2R/FGB/F3/C7/FGG	3.31346142393047
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	7/460	42/9376	3.39710144927536	FTH1/SLC3A2/MAP1LC3A/ACSL3/MAP1LC3B/TFRC/PCBP2	3.53636175841749
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	37/460	480/9376	1.57115942028986	MT-CO2/MT-CO3/MT-CO1/MT-ND4/HSPA5/XBP1/MT-ND5/MT-ATP6/MT-ND4L/WNT5A/WNT4/MT-CYB/MT-ATP8/DKK1/TUBA3E/MAP1LC3A/UBC/COX7A1/ATXN2/MT-ND1/MT-ND2/APP/MAP1LC3B/WNT16/DVL3/BAD/WIPI1/CSNK1E/TUBB2A/GPX3/CYC1/PSMD3/COX6A1/TANK/ATP2A2/ACTR1B/RAF1	2.91783077001991
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	16/460	156/9376	2.09052396878484	PPP2CA/SCARB1/BAD/CLDN4/TRADD/EGFR/YWHAQ/LDLR/PIK3CB/JAK1/YWHAH/IRF3/IFIT1/RAF1/MX1/EIF2AK2	3.11969098704918
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	30/460	368/9376	1.66162570888469	MT-CO2/MT-CO3/MT-CO1/MT-ND4/HSPA5/XBP1/MT-ND5/MT-ATP6/ACTB/PFN1/MT-ND4L/MT-CYB/MT-ATP8/TUBA3E/MAP1LC3A/COX7A1/ATXN2/MT-ND1/MT-ND2/MAP1LC3B/UBQLN2/BAD/WIPI1/TUBB2A/GPX3/CYC1/PSMD3/COX6A1/TANK/ACTR1B	2.94104464429542
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	16/460	157/9376	2.07720852949322	ACTB/WNT5A/WNT4/ID1/WNT16/PPP2CA/TGFB1/DVL3/CSNK1E/YWHAQ/CDH1/YWHAH/PPP1CC/LATS2/TEAD1/RASSF6	3.09162796075415
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	24/460	275/9376	1.77884584980237	MT-CO2/MT-CO3/MT-CO1/MT-ND4/HSPA5/MT-ND5/MT-ATP6/MT-ND4L/MT-CYB/MT-ATP8/TUBA3E/COX7A1/MT-ND1/MT-ND2/EGR1/CAV2/BAD/TUBB2A/CYC1/PIK3CB/PSMD3/COX6A1/C7/LAMC1	2.97750722449291
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	12/460	105/9376	2.32944099378882	ACTB/TPM1/ADRB1/ITGA6/TGFB1/ITGA1/DAG1/ITGB1/SGCB/EMD/ITGB4/ATP2A2	3.11157267806715
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	19/460	205/9376	1.88911983032874	MT-CO2/MT-CO3/MT-CO1/MT-ND4/MT-ND5/MT-ATP6/MT-ND4L/SLC2A1/MT-CYB/MT-ATP8/COX7A1/MT-ND1/MT-ND2/TGFB1/CYC1/PIK3CB/PPP1CC/COX6A1/ATP2A2	2.9235357203687
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	21/460	235/9376	1.82142460684551	MT-CO2/MT-CO3/MT-CO1/MT-ND4/MT-ND5/MT-ATP6/ACTB/MT-ND4L/MT-CYB/MT-ATP8/COX7A1/ACSL3/PNPLA2/MT-ND1/FGFR1/MT-ND2/AKT1S1/CYC1/RHEB/SMARCB1/COX6A1	2.89657187432987
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/460	70/9376	2.62062111801242	EGLN3/EPAS1/SLC2A1/TGFB1/BAD/PIK3CB/VEGFA/RAF1/RAP1B	3.09121002984048
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/460	137/9376	2.08289431926373	TNFSF10/CTSL/ACTB/TUBA3E/FOS/CTSV/GADD45G/BAD/GADD45A/TRADD/CTSF/PIK3CB/SPTAN1/RAF1	2.90010284677925
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/460	59/9376	2.76374355195284	ERBB2/GADD45G/BAD/GADD45A/EGFR/CDH1/PIK3CB/RAF1	3.08676040845976
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/460	17/9376	4.79590792838875	LAMP1/TFRC/DAG1/LAMP2	3.55799170333897
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/460	99/9376	2.26473429951691	ACTB/TPM1/ITGA6/TGFB1/ITGA1/DAG1/ITGB1/SGCB/EMD/ITGB4/ATP2A2	2.87337719036495
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	15/460	155/9376	1.97251051893408	HLA-C/CTSL/HLA-G/ACTB/ATP6V0E1/TUBA3E/PLA2R1/SEC61G/LAMP1/TFRC/SCARB1/ITGB1/TUBB2A/LAMP2/CANX	2.77300510870548
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	18/460	200/9376	1.8344347826087	TNFSF10/ACTB/TUBA3E/TMED10/IL1R1/FOS/F2R/CLDN4/MYO10/CYTH2/ITGB1/TRADD/TUBB2A/WASF2/EZR/MYO5B/GNA12/ABI1	2.70931947300911
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/460	38/9376	3.21830663615561	HEXB/UGDH/HEXA/UXS1/UAP1/PGM3	3.11218901930063
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	12/460	116/9376	2.10854572713643	CD99/ACTB/JAM2/VASP/CLDN4/PXN/ACTN4/ITGB1/PIK3CB/EZR/THY1/RAP1B	2.72870532075731
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/460	103/9376	2.17678345293373	FN1/IL1R2/HSPB1/IL1R1/LAMA5/LAMB2/TGFB1/ACTN4/COL4A2/PIK3CB/LAMC1	2.72762435510919
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	21/460	253/9376	1.69183708540986	ACTB/PFN1/MAP1LC3A/UBC/BNIP3/IL1R1/MAP1LC3B/RRAGA/WIPI1/PXN/ACTN4/AKT1S1/CYTH2/ITGB1/TRADD/EGFR/WASF2/UBE2D3/PIK3CB/UBE2D2/IRF3	2.53381431632328
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/460	52/9376	2.7438127090301	LRPAP1/LRP2/APOA1/SCARB1/LDLR/TSPO/VAPA	2.86404542664002
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/460	78/9376	2.35183946488294	FN1/ACTB/CLTB/CAV2/PXN/ITGB1/WASF2/CDH1/PIK3CB	2.72305977871529
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/460	20/9376	4.07652173913043	CYB5R1/UGDH/CYB5R3/UAP1	3.12830726762123
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	16/460	180/9376	1.81178743961353	HLA-C/HLA-G/PDIA3/BST2/SRSF5/TAPBP/SRSF9/IFNGR2/BAD/TRADD/PIK3CB/RHEB/JAK1/PPP1CC/IRF3/EIF2AK2	2.49780553013665
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/460	93/9376	2.1916783543712	FN1/LAMA5/ITGA6/LAMB2/GADD45G/ITGB1/GADD45A/COL4A2/PIK3CB/LAMC1	2.62322700212704
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	12/460	122/9376	2.00484675694939	ACTB/WNT4/SLC2A1/DIO2/BAD/ATP1A1/PIK3CB/ATP1A4/RHEB/ATP2A2/RAF1/ATP1B3	2.5374326693726
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/460	31/9376	3.2875175315568	GLUL/GCSH/PGP/ACSS1/GLDC	2.89757809209837
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/460	31/9376	3.2875175315568	HSPA5/SEC61G/SEC62/SPCS1/SEC11C	2.89757809209837
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/460	55/9376	2.59415019762846	HEXB/HEXA/NEU1/DEGS1/CERS5/ASAH1/SGPP1	2.69313951572213
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/460	170/9376	1.79846547314578	IGF2/ACTB/WNT5A/WNT4/GSTA1/WNT16/TGFB1/GADD45G/DVL3/BAD/GADD45A/EGFR/PIK3CB/SMARCB1/RAF1	2.38629780012704
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/460	142/9376	1.86601347213717	CTSL/IL1R2/DUSP1/ACTB/HSP90B1/GSTA1/IL1R1/FOS/CAV2/PIK3CB/VEGFA/SUMO1/GPC1	2.36185596632414
Human Diseases	Cancer: specific types	hsa05218	Melanoma	8/460	73/9376	2.23371054198928	FGFR1/GADD45G/BAD/GADD45A/EGFR/CDH1/PIK3CB/RAF1	2.4034922134496
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/460	308/9376	1.52207792207792	MT-CO2/MT-CO3/MT-CO1/MT-ND4/MT-ND5/MT-ATP6/MT-ND4L/TGM2/CLTB/MT-CYB/MT-ATP8/TUBA3E/COX7A1/MT-ND1/MT-ND2/POLR2K/WIPI1/TUBB2A/GPX3/CYC1/PSMD3/COX6A1/ACTR1B	2.11609155782272
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/460	75/9376	2.17414492753623	HSPA5/HSP90B1/LRP2/GPX3/ATP1A1/ATP1A4/ATP1B3/CANX	2.3188200124995
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/460	15/9376	4.07652173913043	HEXB/ST3GAL5/HEXA	2.70846993587061
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	19/460	248/9376	1.56157082748948	TNFSF10/ACTB/PFN1/HSP90B1/RHOB/TUBA3E/FOS/PODXL/FLNA/CYTH2/TRADD/TUBB2A/AHNAK/ACBD3/PIK3CB/ACTR1B/RAF1/ABI1/RRAS	2.0357389578801
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/460	93/9376	1.97251051893408	ACTB/PTPRF/FGFR1/ERBB2/ACTN4/EGFR/WASF2/CDH1/RAP1B	2.14077552366602
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	22/460	300/9376	1.49472463768116	FLT1/IGF2/HSPB1/DUSP1/IL1R1/FOS/FGFR1/ERBB2/TGFB1/GADD45G/PGF/FLNA/JUND/GADD45A/TRADD/EGFR/VEGFA/GNA12/RAF1/MAPK8IP3/RAP1B/RRAS	1.97813736771979
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/460	16/9376	3.82173913043478	MIF/MAOB/MAOA	2.56577430682288
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/460	16/9376	3.82173913043478	HEXB/HEXA/A4GALT	2.56577430682288
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/460	110/9376	1.85296442687747	FBN1/LTBP1/ID3/ID1/TFRC/PPP2CA/TGFB1/ID4/NOG/LEFTY2	2.04390467940573
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	16/460	205/9376	1.59083775185578	HLA-C/IL6ST/HLA-G/GSN/BAD/PXN/ACTN4/TRADD/YWHAQ/PIK3CB/JAK1/YWHAH/RANBP1/IRF3/HDAC5/EIF2AK2	1.94274743805236
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/460	112/9376	1.81987577639752	LAMA5/ITGA6/LAMB2/TGFB1/IFNGR2/BAD/ITGB1/LDLR/JAK1/LAMC1	1.98261011452617
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/460	29/9376	2.81139430284858	CSNK1E/LATS2/TEAD1/RASSF6	2.21899027669283
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/460	212/9376	1.5383100902379	FLT1/ACTB/PFN1/FGFR1/ID1/F2R/PGF/VASP/ITGB1/EGFR/CDH1/PIK3CB/VEGFA/RAF1/RAP1B/RRAS	1.80068370609713
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/460	71/9376	2.00955296999388	LDHA/SLC2A1/FGFR1/ERBB2/EGFR/PIK3CB/RAF1	1.93945461216057
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/460	57/9376	2.14553775743707	FADS1/ACSL3/FASN/ACADVL/FADS2/TECR	1.97034240607011
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	12/460	148/9376	1.65264394829612	WNT5A/WNT4/FOS/FGFR1/WNT16/ERBB2/GADD45G/DVL3/GADD45A/EGFR/PIK3CB/RAF1	1.8177447719668
NA	NA	hsa04519	Cadherin signaling	27/460	404/9376	1.36220404649161	KRT19/ACTB/WNT5A/WNT4/GJA1/FGFR1/GABRE/CDH11/WNT16/ERBB2/DSG2/DVL3/VASP/ACTN4/KRT10/EGFR/YWHAQ/CDH1/YWHAH/PPP1CC/PSENEN/LATS2/NCSTN/SHOC2/RAF1/TEAD1/RRAS	1.69035869580854
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/460	87/9376	1.87426286856572	FOS/TGFB1/GADD45G/BAD/GADD45A/EGFR/PIK3CB/RAF1	1.86078716826756
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	12/460	150/9376	1.63060869565217	WNT5A/WNT4/WNT16/ERBB2/TGFB1/GADD45G/DVL3/GADD45A/EGFR/CDH1/PIK3CB/RAF1	1.76839135687892
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	7/460	73/9376	1.95449672424062	ERBB2/GADD45G/BAD/GADD45A/EGFR/PIK3CB/RAF1	1.8595329831391
Human Diseases	Infectious disease: viral	hsa05162	Measles	11/460	136/9376	1.64859335038363	FOS/CD46/BAD/TRADD/PIK3CB/JAK1/IRF3/IL2RB/ADAR/MX1/EIF2AK2	1.73055531102559
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	9/460	105/9376	1.74708074534161	CITED2/MAP1LC3A/UBC/BNIP3/ATG9B/MAP1LC3B/AMFR/BNIP3L/RRAS	1.74855149372976
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/460	60/9376	2.03826086956522	HSPB1/BAD/PXN/PIK3CB/VEGFA/RAF1	1.83251228939737
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/460	106/9376	1.73059885151764	IL1R2/HSP90B1/FGFR1/ERBB2/BAD/FOLR1/EGFR/PIK3CB/RAF1	1.71819153422367
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	12/460	157/9376	1.55790639711991	IGFBP3/HLA-C/HLA-G/TGFB1/GADD45G/GADD45A/PIK3CB/RHEB/PPP1CC/ZFP36L1/RAF1/RRAS	1.60121180773698
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	12/460	157/9376	1.55790639711991	MT-CO2/MT-CO3/MT-CO1/XBP1/MT-CYB/COX7A1/FOS/ADIPOR1/TGFB1/CYC1/PIK3CB/COX6A1	1.60121180773698
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/460	125/9376	1.63060869565217	SPTSSA/PPP2CA/TRADD/PIK3CB/DEGS1/CERS5/GNA12/ASAH1/RAF1/SGPP1	1.61213031711053
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/460	109/9376	1.68296769046669	IL6ST/EBI3/GATA3/IL1R1/FOS/TGFB1/IFNGR2/JAK1/IL2RB	1.62900849975225
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/460	63/9376	1.94120082815735	WNT5A/WNT4/WNT16/GADD45G/DVL3/GADD45A	1.70250069558593
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/460	22/9376	2.77944664031621	MAOB/AOC1/MAOA	1.89791671759029
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/460	80/9376	1.78347826086957	ERBB2/BAD/EGFR/PIK3CB/VEGFA/JAK1/RAF1	1.59846602813165
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/460	23/9376	2.6586011342155	ATP1A1/ATP1A4/ATP1B3	1.80888073315354
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/460	196/9376	1.45590062111801	HLA-C/IL6ST/HLA-G/MAP1LC3A/UBC/FOS/MAP1LC3B/TRADD/PIK3CB/VEGFA/JAK1/IRF3/RAF1/EIF2AK2	1.46506334633304
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/460	37/9376	2.20352526439483	MIF/MAOB/MAOA/FAHD1	1.6660399451374
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/460	37/9376	2.20352526439483	UGDH/UXS1/UAP1/PGM3	1.6660399451374
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/460	37/9376	2.20352526439483	GADD45G/GADD45A/CDH1/TFG	1.6660399451374
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/460	82/9376	1.73997879109226	HLA-C/HSPA5/CTSL/HLA-G/PDIA3/TAPBP/CANX	1.52863707512965
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/460	67/9376	1.82530824140169	LDHA/ALDOA/ALDOC/TPI1/ACSS1/PGK1	1.53986125707489
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/460	38/9376	2.14553775743707	ATP1A1/PIK3CB/ATP1A4/ATP1B3	1.60714031675459
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	12/460	166/9376	1.47344159245678	EDNRB/ADRB1/VASP/BAD/GTF2I/ATP1A1/ATP1A4/PPP1CC/GNA12/ATP2A2/RAF1/ATP1B3	1.39788087017424
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	9/460	116/9376	1.58140929535232	ALDOA/GCSH/ALDOC/TPI1/PGP/ACSS1/PGK1/H6PD/GLDC	1.43114947712968
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/460	100/9376	1.63060869565217	CD59/IL1R2/IL1R1/ITGA6/TFRC/ITGA1/EPOR/CSF3R	1.43998878337943
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/460	184/9376	1.44007561436673	WNT5A/WNT4/SEMA3A/SEMA3C/SEMA5A/SEMA6A/ITGB1/PIK3CB/PLXNB1/RAF1/RHOD/NTN4/RRAS	1.36933822535247
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	12/460	168/9376	1.45590062111801	PRL/IL6ST/PRLR/IFNGR2/EGFR/EPOR/PIK3CB/JAK1/SOCS2/CSF3R/IL2RB/RAF1	1.35432125233746
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	16/460	238/9376	1.37025940811107	RPS4Y1/IL6ST/CFD/FOS/ISG15/RPL13/EGFR/FGB/PIK3CB/JAK1/C7/IRF3/ADAR/MX1/EIF2AK2/FGG	1.31416086002923
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	12/460	170/9376	1.43877237851662	ACTB/TUBA3E/JAM2/PPP2CA/ERBB2/SYNPO/VASP/CLDN4/ACTN4/ITGB1/EZR/SYMPK	1.31131726646315
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/460	103/9376	1.58311523849726	PRCP/SLC3A2/COL5A2/COL4A2/DPP4/ATP1A1/ATP1A4/ATP1B3	1.35158199445722
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/460	26/9376	2.35183946488294	APOA1/SCARB1/SLC19A3	1.56778142102744
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	6/460	71/9376	1.72247397428047	PRL/PRLR/FOS/PIK3CB/SOCS2/RAF1	1.3879464705975
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	15/460	224/9376	1.36490683229814	HLA-C/IL1R2/HLA-G/SLC2A1/IL1R1/FOS/TGFB1/EGR1/PIK3CB/JAK1/RANBP1/ETS2/IL2RB/TSPO/CANX	1.25553123779362
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/460	41/9376	1.98854718981972	MAOB/GCSH/MAOA/GLDC	1.4408265321409
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/460	173/9376	1.41382256848454	TNFSF10/ACTB/IFNGR2/TRADD/PIK3CB/JAK1/DNAJC3/IRF3/RAF1/ADAR/MX1/EIF2AK2	1.24782027127498
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/460	27/9376	2.26473429951691	FADS1/FADS2/TECR	1.49478290727758
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	15/460	227/9376	1.34686841601226	HLA-C/HLA-G/PDIA3/IL1R1/TAPBP/PXN/TRADD/EGFR/PIK3CB/VEGFA/RHEB/JAK1/GNA12/IRF3/RAF1	1.20162898625089
NA	NA	hsa04517	IgSF CAM signaling	19/460	299/9376	1.29521593718191	ACTB/PTPRF/TUBA3E/JAM2/FGFR1/APP/PXN/ACTN4/SPTBN1/ITGB1/TUBB2A/PPFIA1/FGB/CDH1/PIK3CB/EZR/SPTAN1/FGG/RAP1B	1.17837562293202
Organismal Systems	Digestive system	hsa04976	Bile secretion	7/460	90/9376	1.58531400966184	SLC2A1/SCARB1/SLC4A2/ATP1A1/LDLR/ATP1A4/ATP1B3	1.26728810463433
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/460	158/9376	1.4190423775454	WNT5A/WNT4/SLC3A2/WNT16/DVL3/RRAGA/AKT1S1/SLC38A9/PIK3CB/RHEB/RAF1	1.2065564923678
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	10/460	142/9376	1.43539497856705	IL1R1/FOS/JUNB/TGFB1/IFNGR2/JUND/PIK3CB/JAK1/FHL2/ATP2A2	1.18744137466869
Organismal Systems	Immune system	hsa04611	Platelet activation	9/460	126/9376	1.45590062111801	ACTB/F2R/VASP/ITGB1/FGB/PIK3CB/PPP1CC/FGG/RAP1B	1.1702108330532
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	6/460	76/9376	1.6091533180778	ACTB/SLC4A2/ATP1A1/ATP1A4/EZR/ATP1B3	1.21107617402311
Organismal Systems	Digestive system	hsa04970	Salivary secretion	7/460	93/9376	1.53417484805984	ADRB1/CST3/SLC4A2/ATP1A1/ATP1A4/ATP1B3/VAMP2	1.17587256674396
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/460	77/9376	1.58825522303783	TGFB1/GADD45G/BAD/GADD45A/PIK3CB/RAF1	1.17726045165126
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/460	31/9376	1.97251051893408	ALDOA/ALDOC/H6PD	1.23187041634642
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/460	17/9376	2.39795396419437	GLUL/CA12	1.31033436534502
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/460	115/9376	1.41792060491493	GATA3/FOS/FGFR1/EGR1/JUND/EGFR/GNA12/RAF1	1.02422008021645
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/460	98/9376	1.45590062111801	GSN/ASAP3/VASP/MYO10/WASF2/PIK3CB/RAF1	1.03047049604813
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	9/460	133/9376	1.37927427263812	TNFSF10/BNIP3/TGFB1/GADD45G/CSNK1E/GADD45A/EGFR/PIK3CB/RAF1	1.00058100098327
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/460	32/9376	1.91086956521739	ATG9B/PPP2CA/WIPI1	1.17231491306056
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	13/460	205/9376	1.29255567338282	HLA-C/HLA-G/PDIA3/ISG15/TAPBP/GADD45G/GADD45A/TRADD/PIK3CB/PSMD3/JAK1/IRF3/EIF2AK2	0.961959155736029
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/460	48/9376	1.69855072463768	ATP1A1/PIK3CB/ATP1A4/ATP1B3	1.1020564015778
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/460	82/9376	1.49141039236479	GSTA1/CES1/NME3/CDA/DUT/NME4	1.01514820953723
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/460	33/9376	1.85296442687747	STX16/SNAP29/VAMP2	1.11487002469973
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/460	226/9376	1.26263947672182	FOS/ADRB1/F2R/POMC/BAD/ATP1A1/PIK3CB/ATP1A4/PPP1CC/ATP2A2/RAF1/ATP1B3/RAP1B/RRAS	0.907785415584137
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/460	18/9376	2.26473429951691	ACSL3/FASN	1.21989809473834
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	7/460	101/9376	1.41265604821352	WNT5A/WNT4/EDNRB/WNT16/POMC/DVL3/RAF1	0.947046856202014
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7/460	101/9376	1.41265604821352	FN1/TGFB1/EGR1/COL4A2/PIK3CB/VEGFA/F3	0.947046856202014
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	10/460	155/9376	1.31500701262272	WNT5A/WNT4/RASD1/WNT16/SCARB1/POMC/DVL3/EGFR/LDLR/RAP1B	0.898207308069296
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/460	138/9376	1.32930056710775	PTPRF/FASN/BAD/PIK3CB/RHEB/SOCS2/PPP1CC/PRKAR1A/RAF1	0.885161603828078
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/460	19/9376	2.14553775743707	HEXB/HEXA	1.13526544263766
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/460	19/9376	2.14553775743707	GCSH/GLDC	1.13526544263766
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/460	51/9376	1.59863597612958	ACTB/KDELR2/ATP6V0E1/SEC61G	0.973650306631212
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/460	35/9376	1.74708074534161	ALDOA/ALDOC/TPI1	1.0057369444484
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	15/460	250/9376	1.22295652173913	HLA-C/HLA-G/CLTB/ARF4/ASAP3/TFRC/CAV2/FOLR1/CYTH2/EGFR/ARFGAP3/EPN2/LDLR/IL2RB/RAB11FIP1	0.811576525471062
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/460	69/9376	1.47700063011972	ARC/FOS/MAOB/PPP1CC/MAOA	0.903271204023842
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/460	20/9376	2.03826086956522	SQLE/MSMO1	1.05573738765962
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/460	70/9376	1.45590062111801	SLC2A1/ACSL3/ADIPOR1/POMC/TRADD	0.869595340296993
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	5/460	70/9376	1.45590062111801	HLA-C/HLA-G/ACTB/DAG1/SGCB	0.869595340296993
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	4/460	53/9376	1.5383100902379	CLTB/ATP1A1/ATP1A4/ATP1B3	0.892631353454489
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/460	142/9376	1.29185548071035	UBC/UBE2Q2/UBE2B/UBE2H/UBE2E2/UBE2D3/UBE2D2/UBE2I/STUB1	0.795969844116875
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	13/460	216/9376	1.22673107890499	TNFSF10/HSPA5/XBP1/HSP90B1/FOS/APOA1/CYP2J2/BAD/LDLR/PIK3CB/TANK/IRF3/RAP1B	0.765719518377843
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/460	89/9376	1.37410845139228	TUBA3E/GJA1/ADRB1/TUBB2A/EGFR/RAF1	0.805442096001779
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/460	21/9376	1.94120082815735	CHPF/CHST3	0.980730261696661
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/460	72/9376	1.41545893719807	ISG15/TRADD/TANK/IRF3/ADAR	0.803783389863215
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	14/460	238/9376	1.19897698209719	FLT1/IGF2/RALBP1/FGFR1/PGF/BAD/EGFR/PIK3CB/VEGFA/ETS2/SHOC2/RAF1/RAP1B/RRAS	0.706228541910319
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/460	90/9376	1.35884057971014	FOS/IFNGR2/EGFR/PIK3CB/JAK1/RAF1	0.776940907991401
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	17/460	298/9376	1.16276626787278	TNFSF10/PRL/IL6ST/IL1R2/EBI3/PRLR/IL1RL1/IL1R1/TGFB1/IFNGR2/TNFRSF12A/CCL8/EPOR/INHA/TNFRSF8/CSF3R/IL2RB	0.648570173569631
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/460	130/9376	1.2543143812709	EDNRB/FOS/TGFB1/COL4A2/EGFR/PIK3CB/VEGFA/RAF1	0.663201004916084
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/460	75/9376	1.35884057971014	ALDOA/GLUL/ALDOC/TPI1/PGK1	0.708674626116911
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/460	23/9376	1.77240075614367	PRCP/ATP6AP2	0.84238507814741
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/460	76/9376	1.34096109839817	GADD45G/GADD45A/EGFR/PIK3CB/RAF1	0.677875093649298
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/460	95/9376	1.28732265446224	FLT1/CTSL/ATP6V0E1/FOS/TGFB1/VEGFA	0.639313404662123
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/460	59/9376	1.38187177597642	NME3/CDA/DUT/NME4	0.668320900670112
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/460	78/9376	1.30657748049052	FOS/TGFB1/IFNGR2/ITGB1/JAK1	0.617550254945329
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/460	42/9376	1.45590062111801	MAOB/AOC1/MAOA	0.672574589051244
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/460	98/9376	1.24791481810115	SCARB1/POMC/ATP1A1/LDLR/ATP1A4/ATP1B3	0.560360950945594
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/460	61/9376	1.33656450463293	FTH1/ATP1A1/ATP1A4/ATP1B3	0.598992416044586
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	6/460	99/9376	1.23530961791831	FOS/ERBB2/BAD/EGFR/PIK3CB/RAF1	0.534605006805174
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/460	99/9376	1.23530961791831	FOS/EGFR/WASF2/PIK3CB/RHEB/RAF1	0.534605006805174
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	12/460	214/9376	1.14295002031694	HLA-C/HLA-G/PDIA3/FOS/BST2/TAPBP/BAD/PXN/TRADD/PIK3CB/IRF3/RAF1	0.480480192122415
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	4/460	62/9376	1.31500701262272	TLE1/DVL3/PSENEN/NCSTN	0.565232954223886
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	9/460	157/9376	1.16842979783993	SLC2A1/BSG/MFGE8/ADAM9/TGFB1/EPOR/SLC16A1/CD47/ATP2A2	0.483399692974105
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/460	138/9376	1.18160050409578	FN1/ACTB/FOS/PXN/ITGB1/WASF2/PIK3CB/IRF3	0.488143081177291
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	8/460	139/9376	1.17309978104473	KRT19/HSP90B1/FOS/POMC/KRT10/EGFR/PIK3CB/RAF1	0.467001172537255
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	10/460	178/9376	1.14509037616023	WNT5A/WNT4/NOTUM/DKK1/LGR4/WNT16/TLE1/DVL3/CSNK1E/SFRP2	0.44389620213554
NA	NA	hsa04382	Cornified envelope formation	12/460	217/9376	1.12714886796233	KRT19/S100A4/LAMA5/ITGA6/PPP2CA/PRSS8/DSG2/CLDN4/S100A6/KRT10/COL4A2/ITGB4	0.430425368003125
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/460	102/9376	1.19897698209719	SLC4A2/ATP1A1/ATP1A4/ATP2A2/ATP1B3/RAP1B	0.458932594922276
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/460	160/9376	1.14652173913043	HLA-C/HLA-G/CD99/PTPRF/JAM2/ITGA6/CLDN4/ITGB1/CDH1	0.424590572797973
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	7/460	122/9376	1.16949394155381	RAB2A/FASN/PPP2CA/ADIPOR1/AKT1S1/PIK3CB/RHEB	0.428005028214501
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/460	163/9376	1.12542011202987	HSPG2/FOS/TGFB1/BAD/YWHAQ/PIK3CB/JAK1/IRF3/RAF1	0.36689346400911
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/460	47/9376	1.30101757631822	LDHA/ACSS1/ACYP2	0.469897096168714
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/460	86/9376	1.1850353892821	ERBB2/BAD/EGFR/PIK3CB/RAF1	0.391539598273611
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/460	86/9376	1.1850353892821	SLC2A1/ATP1A1/ATP1A4/ATP1B3/VAMP2	0.391539598273611
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/460	149/9376	1.09436825211555	F2R/CYTH2/EGFR/PIK3CB/RHEB/GNA12/RAF1/RRAS	0.263735328404845
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/460	12/9376	1.69855072463768	VKORC1	0.549967963824383
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/460	12/9376	1.69855072463768	CD46	0.549967963824383
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/460	32/9376	1.27391304347826	LDHA/ACSS1	0.352533840204368
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/460	52/9376	1.17591973244147	SCARB1/CYP2J2/LDLR	0.288931318452752
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/460	93/9376	1.0958391771856	GATA3/FOS/IFNGR2/JAK1/IL2RB	0.210969609821908
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	4/460	73/9376	1.11685527099464	SERINC3/BST2/SMARCB1/MX1	0.227655292207594
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	8/460	154/9376	1.05883681535855	TPM1/ADRB1/PPP2CA/ATP1A1/ATP1A4/PPP1CC/ATP2A2/ATP1B3	0.167215481363309
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/460	115/9376	1.0634404536862	DUSP1/APP/MAOB/CYP2J2/MAOA/RAF1	0.155476867613823
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/460	75/9376	1.08707246376812	GSTA1/ERBB2/BAD/PIK3CB	0.171959497322714
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/460	75/9376	1.08707246376812	IGFBP3/CD82/GADD45G/GADD45A	0.171959497322714
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/460	14/9376	1.45590062111801	CHST2	0.387730002056301
NA	NA	hsa04081	Hormone signaling	11/460	219/9376	1.02378399841175	PRL/IGF2/PRLR/DIO2/RAMP1/ADRB1/ADIPOR1/POMC/EPOR/PIK3CB/GNA12	0.0808927950526207
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	6/460	117/9376	1.04526198439242	ACTB/CDK2AP2/BCL7B/BCL7C/MORF4L2/SMARCB1	0.111898432660799
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/460	76/9376	1.07276887871854	UBC/ACSL3/APOA1/FADS2	0.144674013275488
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	9/460	181/9376	1.01349987989431	PLA2R1/LAMP1/TGFB1/IFNGR2/BAD/TRADD/LAMP2/JAK1/RAF1	0.0416555477369278
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/460	36/9376	1.13236714975845	UGDH/DCXR	0.180733040046557
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/460	140/9376	1.01913043478261	MAP1LC3A/MAP1LC3B/EGR1/CDH1/RAF1/HDAC5/RRAS	0.0517996016954378
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/460	120/9376	1.01913043478261	ARHGDIB/MAGED1/BAD/PIK3CB/RAF1/RAP1B	0.0479052724720834
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/460	79/9376	1.03203082003302	CLTB/ATP6V0E1/SLC6A2/VAMP2	0.064936624802786
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/460	122/9376	1.0024233784747	IGFBP3/FOS/JUNB/PIK3CB/SOCS2/RAF1	0.00611949998288178
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/460	59/9376	1.03640383198231	GSTA1/PRDX6/GPX3	0.0637110237227009
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	3/460	59/9376	1.03640383198231	PNPLA2/ADRB1/PIK3CB	0.0637110237227009
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/460	60/9376	1.01913043478261	PPP2CA/GNA12/RAF1	0.033764883054223
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	5/460	103/9376	0.989447024060785	FOS/PPP2CA/TGFB1/IFNGR2/PIK3CB	-0.0244603661947518
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/460	39/9376	1.04526198439242	GCSH/GLDC	0.0643341753994596
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/460	39/9376	1.04526198439242	HLA-C/HLA-G	0.0643341753994596
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/460	105/9376	0.970600414078675	IL1R1/GADD45G/GADD45A/TRADD/UBE2I	-0.0688100853867712
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	3/460	62/9376	0.986255259467041	CRYAB/AKT1S1/PIK3CB	-0.0246628804603475
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/460	63/9376	0.970600414078675	PTGDS/CYP2J2/PTGES	-0.0531797401612849
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/460	85/9376	0.959181585677749	NME3/CDA/DUT/NME4	-0.0858645477000142
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/460	65/9376	0.940735785953177	SCARB1/POMC/LDLR	-0.108900674173784
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/460	217/9376	0.939290723301944	HSP90B1/GSTA1/FOS/ADRB1/KLF4/BAD/EGFR/PIK3CB/VEGFA/RAF1	-0.205513530578233
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	2/460	43/9376	0.948028311425682	ACSL3/ACADVL	-0.0775836033473407
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/460	43/9376	0.948028311425682	APOA1/SCARB1	-0.0775836033473407
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/460	66/9376	0.926482213438735	GATA3/TGFB1/IFNGR2	-0.136134773922542
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	6/460	133/9376	0.919516181758745	TNFSF10/HLA-C/HLA-G/IFNGR2/PIK3CB/RAF1	-0.212328083470161
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/460	44/9376	0.926482213438735	HLA-C/HLA-G	-0.11102247899417
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/460	44/9376	0.926482213438735	ARHGDIB/VAMP2	-0.11102247899417
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/460	67/9376	0.912654120700844	PPP1CC/RAF1/RAP1B	-0.162970062275736
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/460	134/9376	0.912654120700844	ADM/RAMP1/PPP1CC/GNA12/RAF1/PPP1R12B	-0.231308377560985
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/460	90/9376	0.905893719806763	ADIPOR1/AKT1S1/PIK3CB/RHEB	-0.20375348529446
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/460	45/9376	0.905893719806763	HLA-C/HLA-G	-0.143727639619804
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/460	68/9376	0.89923273657289	ALDH1A2/DHRS3/CYP26B1	-0.189419749357285
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/460	68/9376	0.89923273657289	BAD/PIK3CB/RAF1	-0.189419749357285
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/460	201/9376	0.912654120700844	IGFBP3/FLT1/ASPSCR1/IL1R2/WNT16/GADD45G/GADD45A/MEIS1/IL2RB	-0.284326237179891
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/460	158/9376	0.903026967528894	CDKN1C/PPP2CA/TGFB1/GADD45G/GADD45A/YWHAQ/YWHAH	-0.279216251582883
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/460	47/9376	0.867345050878816	PIK3CB/SOCS2	-0.207078191735075
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/460	71/9376	0.861236987140233	ATP6V0E1/JAM2/EGFR	-0.266577954091705
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/460	94/9376	0.867345050878816	HSP90B1/FOS/JUND/TRADD	-0.293593290409598
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/460	23/9376	0.886200378071834	GLUL	-0.124110576858723
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/460	23/9376	0.886200378071834	POMGNT1	-0.124110576858723
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/460	23/9376	0.886200378071834	PCYOX1	-0.124110576858723
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/460	49/9376	0.831943212067436	MAOB/MAOA	-0.267893782580273
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/460	24/9376	0.84927536231884	EXT2	-0.16792569116146
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/460	73/9376	0.83764145324598	GSTA1/MAOB/MAOA	-0.316303938102906
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/460	254/9376	0.882711400205409	FLT1/EDNRB/FGFR1/ADRB1/ERBB2/F2R/EGFR/ASPH/VEGFA/P2RX4/ATP2A2	-0.430434576031181
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	6/460	144/9376	0.84927536231884	XBP1/ATXN2/WIPI1/PIK3CB/PSMD3/ATP2A2	-0.413996930213365
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/460	99/9376	0.823539745278876	IL1R1/CYP2J2/PIK3CB/PPP1CC	-0.400903866618736
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/460	99/9376	0.823539745278876	KRT19/CFD/KRT10/FGG	-0.400903866618736
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	7/460	168/9376	0.84927536231884	TNFSF10/FTH1/GLUL/IFNGR2/TRADD/JAK1/EIF2AK2	-0.447750168801849
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/460	100/9376	0.815304347826087	TNFSF10/IL6ST/CCL8/IL2RB	-0.421750713720064
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/460	26/9376	0.783946488294314	FADS2	-0.250565759026157
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/460	78/9376	0.783946488294314	FOS/ITGB1/IRF3	-0.435204506939653
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/460	149/9376	0.820776189086665	MT-ND4/MT-ND5/MT-ND4L/MT-ND1/MT-ND2/GABRE	-0.500885091856079
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/460	54/9376	0.754911433172303	HLA-C/HLA-G	-0.410246521189039
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/460	28/9376	0.727950310559006	TECR	-0.327451830412054
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/460	28/9376	0.727950310559006	A4GALT	-0.327451830412054
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/460	28/9376	0.727950310559006	ATP6V0E1	-0.327451830412054
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/460	56/9376	0.727950310559006	LRP2/CSNK1E	-0.463781921889536
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/460	56/9376	0.727950310559006	BNIP3/HSF1	-0.463781921889536
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/460	154/9376	0.794127611518916	ACTB/FOS/EGFR/PPP1CC/RAF1/PPP1R12B	-0.585093709261635
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/460	30/9376	0.679420289855072	PIGT	-0.399450799787519
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/460	30/9376	0.679420289855072	CYP2J2	-0.399450799787519
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/460	30/9376	0.679420289855072	FOLR1	-0.399450799787519
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/460	83/9376	0.736720796228392	POLR2K/IRF3/ADAR	-0.547213946710733
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/460	133/9376	0.766263484798954	FOS/PPP2CA/MAOB/PPP1CC/MAOA	-0.616631111621305
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	4/460	109/9376	0.747985640207419	FOS/PIK3CB/JAK1/IRF3	-0.601102423866061
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/460	109/9376	0.747985640207419	PTPRF/SLC2A1/PIK3CB/PPP1CC	-0.601102423866061
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/460	31/9376	0.65750350631136	UGDH	-0.433837259405532
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/460	31/9376	0.65750350631136	SMOX	-0.433837259405532
NA	NA	hsa04981	Folate transport and metabolism	1/460	31/9376	0.65750350631136	FOLR1	-0.433837259405532
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/460	32/9376	0.63695652173913	GAA	-0.467247232651821
Human Diseases	Immune disease	hsa05310	Asthma	1/460	32/9376	0.63695652173913	PRG2	-0.467247232651821
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/460	89/9376	0.687054225696141	GABRE/GLUL/SLC38A1	-0.673761042959963
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/460	34/9376	0.599488491048593	POLR2K	-0.531390824880477
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/460	34/9376	0.599488491048593	CSNK1E	-0.531390824880477
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/460	91/9376	0.671954132823698	FOS/PIK3CB/RAF1	-0.714239454692189
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/460	65/9376	0.627157190635452	PIK3CB/RAF1	-0.68511552804139
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/460	36/9376	0.566183574879227	GAA	-0.592329452415357
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/460	36/9376	0.566183574879227	GALNT2	-0.592329452415357
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/460	36/9376	0.566183574879227	RNASEH2C	-0.592329452415357
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	3/460	93/9376	0.65750350631136	EGR1/EGFR/RAF1	-0.753933347100146
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/460	144/9376	0.707729468599034	FASN/ADIPOR1/TRADD/ACADVL/IRF3	-0.802782508907326
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/460	119/9376	0.685129704055535	FOS/JUNB/TRADD/PIK3CB	-0.785144450361447
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/460	37/9376	0.550881316098707	GLUL	-0.621714964881385
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/460	37/9376	0.550881316098707	APOA1	-0.621714964881385
Cellular Processes	Cell motility	hsa04814	Motor proteins	7/460	194/9376	0.735454952935903	ACTB/TPM1/TUBA3E/MYO10/TUBB2A/MYO5B/ACTR1B	-0.845690359333179
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/460	122/9376	0.668282252316465	FOS/PPP2CA/PIK3CB/RAF1	-0.837651556480357
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/460	69/9376	0.590800252047889	PIK3CB/RAF1	-0.774880211219396
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/460	70/9376	0.582360248447205	HSD11B1/GSTA1	-0.796615676860624
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/460	41/9376	0.497136797454931	GABRE	-0.732932784317972
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	14/460	370/9376	0.77123384253819	TAC3/PRL/ADM/PRLR/EDNRB/GABRE/ADRB1/F2R/POMC/PGRMC1/PGRMC2/P2RX4/NPW/TSPO	-1.01977930035999
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	5/460	154/9376	0.661773009599096	NME3/UGDH/DHRS3/VKORC1/NME4	-0.961248304574107
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/460	103/9376	0.593668214436471	PPP2CA/PPP1CC/SYMPK	-0.941821939962731
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/460	44/9376	0.463241106719368	GTF2I	-0.810583475667109
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/460	105/9376	0.582360248447205	PIK3CB/RAF1/RRAS	-0.977490874945036
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/460	45/9376	0.452946859903382	ABCA7	-0.835509132984939
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/460	78/9376	0.52263099219621	TPI1/PIK3CB	-0.961581887882144
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/460	46/9376	0.443100189035917	FTH1	-0.859992549109807
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/460	46/9376	0.443100189035917	PSMD3	-0.859992549109807
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/460	107/9376	0.571475010158472	LDHA/SLC2A1/PPP4C	-1.01258415025336
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	6/460	187/9376	0.653987444780284	MAP1LC3A/MAP1LC3B/JAK1/ANTXR2/TANK/IRF3	-1.08557056568571
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/460	79/9376	0.516015410016511	HSD11B1/GSTA1	-0.981190169270963
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/460	138/9376	0.590800252047889	PPP2CA/YWHAQ/YWHAH/PPP1CC	-1.09993100942586
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/460	49/9376	0.415971606033718	GALNT2	-0.930980399653303
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/460	193/9376	0.633656228880379	BAD/PXN/CCL8/PIK3CB/RAF1/RAP1B	-1.16803188460121
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/460	50/9376	0.407652173913043	TGFB1	-0.953879729077409
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/460	50/9376	0.407652173913043	TGFB1	-0.953879729077409
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/460	83/9376	0.491147197485595	UBE2D3/UBE2D2	-1.05762759219022
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/460	83/9376	0.491147197485595	ACSL3/PRDX5	-1.05762759219022
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/460	195/9376	0.627157190635452	ACTB/FGB/PIK3CB/RAF1/HDAC5/FGG	-1.19502669774257
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/460	51/9376	0.399658994032396	ENPP2	-0.976423449059668
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	11/460	323/9376	0.694144568582582	TIMP3/TPM1/ERBB2/EGFR/PIK3CB/VEGFA/TNXB/EZR/UBE2I/RAF1/HDAC5	-1.27057621829475
NA	NA	hsa04082	Neuroactive ligand signaling	6/460	199/9376	0.614551015949312	TAC3/GABRE/ADRB1/POMC/SLC6A2/P2RX4	-1.24831043752544
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/460	54/9376	0.377455716586151	LDHA	-1.04205850914377
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/460	97/9376	0.42025997310623	RASD1/FOS	-1.30361122154372
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/460	63/9376	0.323533471359558	PLOD1	-1.22363336399276
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/460	63/9376	0.323533471359558	POLR2K	-1.22363336399276
Human Diseases	Substance dependence	hsa05034	Alcoholism	5/460	191/9376	0.53357614386524	MAOB/PPP1CC/MAOA/RAF1/HDAC5	-1.479235710211
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/460	65/9376	0.313578595317726	PNPLA2	-1.261330381909
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/460	66/9376	0.308827404479578	HSD11B1	-1.27986205017501
Genetic Information Processing	Translation	hsa03010	Ribosome	6/460	222/9376	0.550881316098707	RPS4Y1/MT-RNR1/MRPL41/MRPS6/MRPL23/RPL13	-1.53819600811365
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	2/460	104/9376	0.391973244147157	PEMT/MBOAT7	-1.41622472718973
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/460	69/9376	0.295400126023945	ADRB1	-1.33426401630048
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	2/460	108/9376	0.377455716586151	UBE2I/SUMO1	-1.47798027771247
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/460	110/9376	0.370592885375494	PIK3CB/RAF1	-1.50820843905731
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/460	115/9376	0.354480151228733	FOS/PIK3CB	-1.58200955759143
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/460	116/9376	0.351424287856072	GLUL/SLC38A1	-1.59648082466813
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/460	128/9376	0.318478260869565	NME3/NME4	-1.76335726686547
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/460	91/9376	0.223984710941233	GABRE	-1.6895830502637
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/460	98/9376	0.207985803016859	PIK3CB	-1.79018677456706
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/460	143/9376	0.285071450288842	ACTN4/C7	-1.95676542256436
Genetic Information Processing	Transcription	hsa03040	Spliceosome	4/460	243/9376	0.335516192521023	SNRNP70/SRSF5/SRSF9/SF1	-2.38374795997984
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/460	183/9376	0.222760750772155	EIF6/SBDS	-2.41174375449726