ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0045296 cadherin binding 42/784 334/18639 0.125748502994012 2.9895744225834 2.28311287515828e-10 2.134710538273e-07 GO:0005178 integrin binding 27/784 161/18639 0.167701863354037 3.98698345797947 7.46924433327871e-10 3.4918717258078e-07 GO:0019838 growth factor binding 23/784 136/18639 0.169117647058824 4.02064263205282 1.14368290871941e-08 3.56447839884216e-06 GO:0016860 intramolecular oxidoreductase activity 14/784 53/18639 0.264150943396226 6.27998652291105 2.52446413593176e-08 5.90093491774049e-06 GO:0005201 extracellular matrix structural constituent 25/784 168/18639 0.148809523809524 3.53783254373178 3.8163895700813e-08 7.13664849605202e-06 GO:0031994 insulin-like growth factor I binding 7/784 13/18639 0.538461538461538 12.801510989011 3.1179698600999e-07 4.42231870551172e-05 GO:0009055 electron transfer activity 19/784 116/18639 0.163793103448276 3.89405568261787 3.57236270410096e-07 4.42231870551172e-05 GO:0003756 protein disulfide isomerase activity 8/784 19/18639 0.421052631578947 10.0102040816327 4.72975262621575e-07 4.42231870551172e-05 GO:0005520 insulin-like growth factor binding 8/784 19/18639 0.421052631578947 10.0102040816327 4.72975262621575e-07 4.42231870551172e-05 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 8/784 19/18639 0.421052631578947 10.0102040816327 4.72975262621575e-07 4.42231870551172e-05 GO:0050840 extracellular matrix binding 13/784 67/18639 0.194029850746269 4.61291120925982 3.6178963354708e-06 0.000307521188515018 GO:0005518 collagen binding 13/784 72/18639 0.180555555555556 4.29257015306122 8.32891730570067e-06 0.000636198956770976 GO:0022853 active monoatomic ion transmembrane transporter activity 17/784 118/18639 0.144067796610169 3.42510160843999 8.84554699253764e-06 0.000636198956770976 GO:0005539 glycosaminoglycan binding 26/784 242/18639 0.107438016528926 2.55425662000337 1.17633994244828e-05 0.000774245582396981 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 11/784 54/18639 0.203703703703704 4.84289965986394 1.24210521240157e-05 0.000774245582396981 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 12/784 68/18639 0.176470588235294 4.19545318127251 2.34790917041474e-05 0.00133436126015457 GO:0001968 fibronectin binding 8/784 30/18639 0.266666666666667 6.33979591836735 2.42611138209922e-05 0.00133436126015457 GO:0015036 disulfide oxidoreductase activity 9/784 40/18639 0.225 5.34920280612245 3.32571437569993e-05 0.00172752385626635 GO:0008201 heparin binding 20/784 172/18639 0.116279069767442 2.76444589463692 3.82455226053929e-05 0.00188208229663381 GO:0015035 protein-disulfide reductase activity 8/784 34/18639 0.235294117647059 5.59393757503001 6.48278538984401e-05 0.00303070216975208 GO:0015399 primary active transmembrane transporter activity 19/784 166/18639 0.114457831325301 2.72114734447996 7.3549630391399e-05 0.00327470973409324 GO:0031543 peptidyl-proline dioxygenase activity 5/784 12/18639 0.416666666666667 9.90593112244898 8.04278209622412e-05 0.00341818239089525 GO:0031418 L-ascorbic acid binding 6/784 20/18639 0.3 7.13227040816327 0.000126844787892781 0.00515651637738045 GO:0001618 virus receptor activity 12/784 81/18639 0.148148148148148 3.52210884353741 0.000138342635191106 0.00524631591908046 GO:0030246 carbohydrate binding 26/784 280/18639 0.0928571428571429 2.20760750728863 0.000140275826713381 0.00524631591908046 GO:0140272 exogenous protein binding 12/784 82/18639 0.146341463414634 3.47915629666501 0.000155958990008282 0.00544398879071569 GO:0043236 laminin binding 7/784 29/18639 0.241379310344828 5.73860837438424 0.000157206093421736 0.00544398879071569 GO:0002020 protease binding 16/784 136/18639 0.117647058823529 2.79696878751501 0.00019370116037097 0.00646823517667345 GO:0016853 isomerase activity 19/784 180/18639 0.105555555555556 2.50950255102041 0.000215529493842309 0.0069489681635365 GO:0061650 ubiquitin-like protein conjugating enzyme activity 8/784 41/18639 0.195121951219512 4.63887506222001 0.000262960600014029 0.0081956053671039 GO:0004129 cytochrome-c oxidase activity 5/784 15/18639 0.333333333333333 7.92474489795918 0.00027442171100466 0.00827691289643087 GO:0033218 amide binding 23/784 247/18639 0.0931174089068826 2.21379513343799 0.000319991687072448 0.00934975710664809 GO:0038024 cargo receptor activity 10/784 65/18639 0.153846153846154 3.65757456828885 0.000359832051688482 0.010195241464507 GO:0019955 cytokine binding 16/784 144/18639 0.111111111111111 2.64158163265306 0.000373358988032043 0.0102673721708812 GO:0016675 oxidoreductase activity, acting on a heme group of donors 5/784 16/18639 0.3125 7.42944834183673 0.000385394958415745 0.0102955510319635 GO:0051787 misfolded protein binding 5/784 17/18639 0.294117647058824 6.99242196878752 0.000527169941093325 0.0133787286281888 GO:0044389 ubiquitin-like protein ligase binding 27/784 322/18639 0.0838509316770186 1.99349172898973 0.000542636435402684 0.0133787286281888 GO:0061631 ubiquitin conjugating enzyme activity 7/784 35/18639 0.2 4.75484693877551 0.000543734425530668 0.0133787286281888 GO:0003779 actin binding 34/784 443/18639 0.0767494356659142 1.8246590961441 0.00056588539580872 0.0135667396174655 GO:1901681 sulfur compound binding 24/784 275/18639 0.0872727272727273 2.07484230055659 0.000616238187801529 0.0144045676398607 GO:0004896 cytokine receptor activity 12/784 96/18639 0.125 2.97177933673469 0.000688109940762696 0.0156922632832469 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 4/784 11/18639 0.363636363636364 8.64517625231911 0.000808734132827972 0.018003962242718 GO:0005109 frizzled binding 7/784 38/18639 0.184210526315789 4.37946428571429 0.000914620317583707 0.0187229053464752 GO:0005501 retinoid binding 7/784 38/18639 0.184210526315789 4.37946428571429 0.000914620317583707 0.0187229053464752 GO:0019840 isoprenoid binding 7/784 38/18639 0.184210526315789 4.37946428571429 0.000914620317583707 0.0187229053464752 GO:0045499 chemorepellent activity 6/784 28/18639 0.214285714285714 5.09447886297376 0.000924812799059046 0.0187229053464752 GO:0031406 carboxylic acid binding 18/784 187/18639 0.0962566844919786 2.28842900796682 0.00094115139174795 0.0187229053464752 GO:0003714 transcription corepressor activity 19/784 204/18639 0.0931372549019608 2.21426695678271 0.00102379041470552 0.0192397963125036 GO:0048029 monosaccharide binding 10/784 74/18639 0.135135135135135 3.21273441809156 0.00102839971104454 0.0192397963125036 GO:0031625 ubiquitin protein ligase binding 25/784 302/18639 0.0827814569536424 1.96806578591702 0.00102886611296811 0.0192397963125036 GO:0043177 organic acid binding 18/784 189/18639 0.0952380952380952 2.26421282798834 0.00106408688306577 0.0195082595228724 GO:0016798 hydrolase activity, acting on glycosyl bonds 14/784 130/18639 0.107692307692308 2.5603021978022 0.00115498744688479 0.0207675627468707 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 5/784 20/18639 0.25 5.94355867346939 0.00118925828468018 0.0209803112486031 GO:0051087 protein-folding chaperone binding 14/784 134/18639 0.104477611940299 2.48387526652452 0.00154804615673361 0.0268041325286282 GO:0070325 lipoprotein particle receptor binding 6/784 31/18639 0.193548387096774 4.60146477946017 0.00162349113058723 0.0275993492199829 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 17/784 181/18639 0.0939226519337017 2.2329391701432 0.00168245821106164 0.0280910433454041 GO:0008375 acetylglucosaminyltransferase activity 7/784 43/18639 0.162790697674419 3.87022425249169 0.0019468203420089 0.0319346845575144 GO:0016757 glycosyltransferase activity 22/784 267/18639 0.0823970037453183 1.95892570511351 0.00212489001593759 0.0336827258533491 GO:0015078 proton transmembrane transporter activity 17/784 185/18639 0.0918918918918919 2.18465940430226 0.00212543403780492 0.0336827258533491 GO:0044548 S100 protein binding 4/784 14/18639 0.285714285714286 6.79263848396501 0.00221753481849395 0.0345565842548641 GO:0001540 amyloid-beta binding 10/784 83/18639 0.120481927710843 2.86436562576838 0.00248299202712936 0.0379717509298378 GO:0016504 peptidase activator activity 8/784 57/18639 0.140350877192982 3.33673469387755 0.00251791289588229 0.0379717509298378 GO:0030215 semaphorin receptor binding 5/784 24/18639 0.208333333333333 4.95296556122449 0.00283626055680211 0.0414359940720309 GO:0050431 transforming growth factor beta binding 5/784 24/18639 0.208333333333333 4.95296556122449 0.00283626055680211 0.0414359940720309 GO:0022804 active transmembrane transporter activity 32/784 457/18639 0.0700218818380744 1.66471665252534 0.00348235200431846 0.0500922942159655 GO:0005521 lamin binding 4/784 16/18639 0.25 5.94355867346939 0.0037703635512421 0.0526162674688263 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 4/784 16/18639 0.25 5.94355867346939 0.0037703635512421 0.0526162674688263 GO:0016758 hexosyltransferase activity 17/784 197/18639 0.0862944162436548 2.05158370454781 0.0040765389377522 0.0546979905739694 GO:0005160 transforming growth factor beta receptor binding 5/784 26/18639 0.192307692307692 4.57196821036107 0.00409503672746295 0.0546979905739694 GO:0050750 low-density lipoprotein particle receptor binding 5/784 26/18639 0.192307692307692 4.57196821036107 0.00409503672746295 0.0546979905739694 GO:0019842 vitamin binding 14/784 150/18639 0.0933333333333333 2.21892857142857 0.00439327985419635 0.0578551642770928 GO:0005507 copper ion binding 8/784 63/18639 0.126984126984127 3.01895043731778 0.00473510244876009 0.0586622601895789 GO:0005092 GDP-dissociation inhibitor activity 4/784 17/18639 0.235294117647059 5.59393757503001 0.00476826927744171 0.0586622601895789 GO:0008429 phosphatidylethanolamine binding 4/784 17/18639 0.235294117647059 5.59393757503001 0.00476826927744171 0.0586622601895789 GO:0032977 membrane insertase activity 4/784 17/18639 0.235294117647059 5.59393757503001 0.00476826927744171 0.0586622601895789 GO:0038191 neuropilin binding 4/784 17/18639 0.235294117647059 5.59393757503001 0.00476826927744171 0.0586622601895789 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 10/784 91/18639 0.10989010989011 2.61255326306347 0.00486349227528652 0.0590566919141935 GO:0019887 protein kinase regulator activity 20/784 255/18639 0.0784313725490196 1.86464585834334 0.00572031349340065 0.0685704245683283 GO:0046332 SMAD binding 9/784 79/18639 0.113924050632911 2.70845711702402 0.00583150361255943 0.0690184288321907 GO:0030228 lipoprotein particle receptor activity 4/784 18/18639 0.222222222222222 5.28316326530612 0.00592925696265472 0.069298190751027 GO:0016918 retinal binding 4/784 19/18639 0.210526315789474 5.00510204081633 0.00726408417656709 0.0838508482109905 GO:0042056 chemoattractant activity 6/784 42/18639 0.142857142857143 3.39631924198251 0.00782396594648783 0.0892122946337332 GO:0004860 protein kinase inhibitor activity 9/784 84/18639 0.107142857142857 2.54723943148688 0.00867261979365535 0.097697584422503 GO:0140297 DNA-binding transcription factor binding 32/784 488/18639 0.0655737704918033 1.55896620943459 0.00896942094490221 0.0998381974224234 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 3/784 11/18639 0.272727272727273 6.48388218923933 0.00949432310685797 0.10203669086106 GO:0034713 type I transforming growth factor beta receptor binding 3/784 11/18639 0.272727272727273 6.48388218923933 0.00949432310685797 0.10203669086106 GO:0097493 structural molecule activity conferring elasticity 3/784 11/18639 0.272727272727273 6.48388218923933 0.00949432310685797 0.10203669086106 GO:0030296 protein tyrosine kinase activator activity 5/784 33/18639 0.151515151515152 3.60215677179963 0.0116029098689867 0.123280917357984 GO:0017166 vinculin binding 3/784 12/18639 0.25 5.94355867346939 0.0122681350462237 0.12888434009235 GO:0030021 extracellular matrix structural constituent conferring compression resistance 4/784 22/18639 0.181818181818182 4.32258812615955 0.0124081562406838 0.128906956500437 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 7/784 60/18639 0.116666666666667 2.77366071428571 0.0126334599748392 0.12980533051071 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 24/784 349/18639 0.0687679083094556 1.63490439155605 0.0128580649377757 0.130677073008916 GO:0019210 kinase inhibitor activity 9/784 90/18639 0.1 2.37742346938776 0.0133417981341106 0.134135282316058 GO:0001664 G protein-coupled receptor binding 21/784 297/18639 0.0707070707070707 1.68100649350649 0.0144268875366383 0.141525512041457 GO:0004602 glutathione peroxidase activity 4/784 23/18639 0.173913043478261 4.1346495119787 0.0145309616641496 0.141525512041457 GO:0140103 catalytic activity, acting on a glycoprotein 4/784 23/18639 0.173913043478261 4.1346495119787 0.0145309616641496 0.141525512041457 GO:0061134 peptidase regulator activity 17/784 226/18639 0.0752212389380531 1.78832738847752 0.0151207195494829 0.145751265760479 GO:0005496 steroid binding 10/784 108/18639 0.0925925925925926 2.20131802721088 0.0155738231581263 0.148586986253552 GO:0042562 hormone binding 9/784 94/18639 0.0957446808510638 2.2762565132436 0.0173515511265676 0.163875760639805 GO:0043394 proteoglycan binding 5/784 37/18639 0.135135135135135 3.21273441809156 0.0185790073967243 0.173713719159372 GO:0008191 metalloendopeptidase inhibitor activity 3/784 14/18639 0.214285714285714 5.09447886297376 0.0190679511271835 0.174691894450634 GO:0019207 kinase regulator activity 20/784 287/18639 0.0696864111498258 1.65674109365 0.0192008759649558 0.174691894450634 GO:0015662 P-type ion transporter activity 4/784 25/18639 0.16 3.80387755102041 0.0194309700779315 0.174691894450634 GO:0140358 P-type transmembrane transporter activity 4/784 25/18639 0.16 3.80387755102041 0.0194309700779315 0.174691894450634 GO:0005041 low-density lipoprotein particle receptor activity 3/784 15/18639 0.2 4.75484693877551 0.0231039085582205 0.200019949092002 GO:0031386 protein tag activity 3/784 15/18639 0.2 4.75484693877551 0.0231039085582205 0.200019949092002 GO:0033130 acetylcholine receptor binding 3/784 15/18639 0.2 4.75484693877551 0.0231039085582205 0.200019949092002 GO:0141047 molecular tag activity 3/784 15/18639 0.2 4.75484693877551 0.0231039085582205 0.200019949092002 GO:0005126 cytokine receptor binding 19/784 275/18639 0.0690909090909091 1.64258348794063 0.0238635347331485 0.204700963077925 GO:0071949 FAD binding 5/784 40/18639 0.125 2.97177933673469 0.0253162884180787 0.215188451553669 GO:0140313 molecular sequestering activity 6/784 55/18639 0.109090909090909 2.59355287569573 0.0273887551910655 0.230122666394056 GO:0005159 insulin-like growth factor receptor binding 3/784 16/18639 0.1875 4.45766900510204 0.0275654958675232 0.230122666394056 GO:0008137 NADH dehydrogenase (ubiquinone) activity 5/784 41/18639 0.121951219512195 2.89929691388751 0.0278674790230502 0.230584892801345 GO:0050660 flavin adenine dinucleotide binding 8/784 86/18639 0.0930232558139535 2.21155671570954 0.0281275079469097 0.230694911669829 GO:0044325 transmembrane transporter binding 11/784 136/18639 0.0808823529411765 1.92291604141657 0.0285652683309383 0.232248051212411 GO:0019894 kinesin binding 5/784 42/18639 0.119047619047619 2.83026603498542 0.0305760618712343 0.246453602151759 GO:0016651 oxidoreductase activity, acting on NAD(P)H 8/784 88/18639 0.0909090909090909 2.16129406307978 0.0317065951789297 0.252426609184559 GO:0004601 peroxidase activity 6/784 57/18639 0.105263157894737 2.50255102040816 0.0319765624671543 0.252426609184559 GO:0140375 immune receptor activity 12/784 156/18639 0.0769230769230769 1.82878728414443 0.0321270229871257 0.252426609184559 GO:0048038 quinone binding 3/784 17/18639 0.176470588235294 4.19545318127251 0.0324506158511121 0.252844381839915 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 6/784 58/18639 0.103448275862069 2.45940358902182 0.0344468867298878 0.266180488367315 GO:0004175 endopeptidase activity 25/784 405/18639 0.0617283950617284 1.46754535147392 0.0364059735075642 0.277264431035232 GO:0003954 NADH dehydrogenase activity 5/784 44/18639 0.113636363636364 2.70161757884972 0.0364743583073086 0.277264431035232 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6/784 59/18639 0.101694915254237 2.41771878242823 0.0370370682251541 0.279271441859025 GO:0098631 cell adhesion mediator activity 7/784 76/18639 0.0921052631578947 2.18973214285714 0.040466388039226 0.30268858253341 GO:0019903 protein phosphatase binding 11/784 144/18639 0.0763888888888889 1.81608737244898 0.0408007041947819 0.302767130334294 GO:0008194 UDP-glycosyltransferase activity 11/784 145/18639 0.0758620689655172 1.80356263194933 0.042550838048954 0.313267980911591 GO:0030291 protein serine/threonine kinase inhibitor activity 5/784 46/18639 0.108695652173913 2.58415594498669 0.0430258108122771 0.314290102417805 GO:0034987 immunoglobulin receptor binding 3/784 19/18639 0.157894736842105 3.75382653061224 0.0434719132760979 0.315087123357764 GO:0019199 transmembrane receptor protein kinase activity 7/784 78/18639 0.0897435897435897 2.13358516483516 0.0455688224665508 0.326873317324694 GO:0003712 transcription coregulator activity 29/784 495/18639 0.0585858585858586 1.39283395176252 0.04579722413854 0.326873317324694 GO:0005504 fatty acid binding 5/784 47/18639 0.106382978723404 2.52917390360399 0.0465496140960548 0.329726433180388 GO:0004857 enzyme inhibitor activity 25/784 416/18639 0.0600961538461538 1.42874006573783 0.0473846999588321 0.333118003469985 GO:0033293 monocarboxylic acid binding 7/784 79/18639 0.0886075949367089 2.10657775768535 0.0482677328512131 0.334966489263401 GO:0140416 transcription regulator inhibitor activity 4/784 33/18639 0.121212121212121 2.8817254174397 0.0483641455086195 0.334966489263401 GO:0001972 retinoic acid binding 3/784 20/18639 0.15 3.56613520408163 0.0495935231513731 0.338466745595138 GO:0016004 phospholipase activator activity 3/784 20/18639 0.15 3.56613520408163 0.0495935231513731 0.338466745595138 GO:0015101 organic cation transmembrane transporter activity 7/784 81/18639 0.0864197530864197 2.05456349206349 0.0539649022561221 0.363888814395299 GO:0060590 ATPase regulator activity 5/784 49/18639 0.102040816326531 2.42594231570179 0.0540968397871087 0.363888814395299 GO:0019208 phosphatase regulator activity 9/784 117/18639 0.0769230769230769 1.82878728414443 0.0583903466235029 0.389964100664109 GO:0005506 iron ion binding 11/784 154/18639 0.0714285714285714 1.69815962099125 0.0606604815859532 0.396163251176617 GO:0042277 peptide binding 16/784 249/18639 0.0642570281124498 1.52766166707647 0.0617164020433951 0.396163251176617 GO:0016500 protein-hormone receptor activity 6/784 67/18639 0.0895522388059701 2.1290359427353 0.062214121760147 0.396163251176617 GO:0005010 insulin-like growth factor receptor activity 5/784 51/18639 0.0980392156862745 2.33080732292917 0.0623111740880403 0.396163251176617 GO:0004190 aspartic-type endopeptidase activity 4/784 36/18639 0.111111111111111 2.64158163265306 0.0631655759203233 0.396163251176617 GO:0005131 growth hormone receptor binding 2/784 10/18639 0.2 4.75484693877551 0.0635556017930402 0.396163251176617 GO:0005528 FK506 binding 2/784 10/18639 0.2 4.75484693877551 0.0635556017930402 0.396163251176617 GO:0008239 dipeptidyl-peptidase activity 2/784 10/18639 0.2 4.75484693877551 0.0635556017930402 0.396163251176617 GO:0015658 branched-chain amino acid transmembrane transporter activity 2/784 10/18639 0.2 4.75484693877551 0.0635556017930402 0.396163251176617 GO:0030957 Tat protein binding 2/784 10/18639 0.2 4.75484693877551 0.0635556017930402 0.396163251176617 GO:0032934 sterol binding 6/784 68/18639 0.0882352941176471 2.09772659063625 0.0659286741339845 0.405548094179444 GO:1990841 promoter-specific chromatin binding 6/784 68/18639 0.0882352941176471 2.09772659063625 0.0659286741339845 0.405548094179444 GO:0008236 serine-type peptidase activity 13/784 194/18639 0.0670103092783505 1.59311881969283 0.0665158964160828 0.406486033653839 GO:0004252 serine-type endopeptidase activity 12/784 176/18639 0.0681818181818182 1.62097054730983 0.0684518303685925 0.411865189507449 GO:0070001 aspartic-type peptidase activity 4/784 37/18639 0.108108108108108 2.57018753447325 0.0685700084686383 0.411865189507449 GO:0030295 protein kinase activator activity 10/784 139/18639 0.0719424460431655 1.71037659668184 0.0687380917611595 0.411865189507449 GO:0051082 unfolded protein binding 9/784 121/18639 0.0743801652892562 1.76833150615618 0.0691581120349407 0.411865189507449 GO:0016209 antioxidant activity 7/784 86/18639 0.0813953488372093 1.93511212624585 0.0699786385834711 0.413294653106479 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 3/784 23/18639 0.130434782608696 3.10098713398403 0.0702821923464493 0.413294653106479 GO:0017171 serine hydrolase activity 13/784 198/18639 0.0656565656565657 1.56093460111317 0.0754066069990221 0.422282882007881 GO:0003953 NAD+ nucleosidase activity 2/784 11/18639 0.181818181818182 4.32258812615955 0.0755692192788585 0.422282882007881 GO:0005114 type II transforming growth factor beta receptor binding 2/784 11/18639 0.181818181818182 4.32258812615955 0.0755692192788585 0.422282882007881 GO:0008503 benzodiazepine receptor activity 2/784 11/18639 0.181818181818182 4.32258812615955 0.0755692192788585 0.422282882007881 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 2/784 11/18639 0.181818181818182 4.32258812615955 0.0755692192788585 0.422282882007881 GO:0032050 clathrin heavy chain binding 2/784 11/18639 0.181818181818182 4.32258812615955 0.0755692192788585 0.422282882007881 GO:0032794 GTPase activating protein binding 2/784 11/18639 0.181818181818182 4.32258812615955 0.0755692192788585 0.422282882007881 GO:0050786 RAGE receptor binding 2/784 11/18639 0.181818181818182 4.32258812615955 0.0755692192788585 0.422282882007881 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 5/784 54/18639 0.0925925925925926 2.20131802721088 0.0758754269276193 0.422282882007881 GO:0035035 histone acetyltransferase binding 3/784 24/18639 0.125 2.97177933673469 0.0779125195551394 0.428518857553267 GO:0060229 lipase activator activity 3/784 24/18639 0.125 2.97177933673469 0.0779125195551394 0.428518857553267 GO:0019888 protein phosphatase regulator activity 8/784 107/18639 0.0747663551401869 1.7775128743086 0.0816184073293255 0.446276086859177 GO:0000030 mannosyltransferase activity 3/784 25/18639 0.12 2.85290816326531 0.0858872763020315 0.458302904317974 GO:0005537 D-mannose binding 3/784 25/18639 0.12 2.85290816326531 0.0858872763020315 0.458302904317974 GO:0019211 phosphatase activator activity 3/784 25/18639 0.12 2.85290816326531 0.0858872763020315 0.458302904317974 GO:0003995 acyl-CoA dehydrogenase activity 2/784 12/18639 0.166666666666667 3.96237244897959 0.0882294361253855 0.458302904317974 GO:0005527 macrolide binding 2/784 12/18639 0.166666666666667 3.96237244897959 0.0882294361253855 0.458302904317974 GO:0016208 AMP binding 2/784 12/18639 0.166666666666667 3.96237244897959 0.0882294361253855 0.458302904317974 GO:0035259 nuclear glucocorticoid receptor binding 2/784 12/18639 0.166666666666667 3.96237244897959 0.0882294361253855 0.458302904317974 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 2/784 12/18639 0.166666666666667 3.96237244897959 0.0882294361253855 0.458302904317974 GO:0097677 STAT family protein binding 2/784 12/18639 0.166666666666667 3.96237244897959 0.0882294361253855 0.458302904317974 GO:0043178 alcohol binding 7/784 92/18639 0.0760869565217391 1.80890916149068 0.0925563985434205 0.474747046109283 GO:0052689 carboxylic ester hydrolase activity 7/784 92/18639 0.0760869565217391 1.80890916149068 0.0925563985434205 0.474747046109283 GO:0034237 protein kinase A regulatory subunit binding 3/784 26/18639 0.115384615384615 2.74318092621664 0.0941917921332271 0.474747046109283 GO:0070412 R-SMAD binding 3/784 26/18639 0.115384615384615 2.74318092621664 0.0941917921332271 0.474747046109283 GO:0019209 kinase activator activity 10/784 148/18639 0.0675675675675676 1.60636720904578 0.0948770464350466 0.474747046109283 GO:0003725 double-stranded RNA binding 6/784 75/18639 0.08 1.9019387755102 0.0954571600733104 0.474747046109283 GO:0019003 GDP binding 6/784 75/18639 0.08 1.9019387755102 0.0954571600733104 0.474747046109283 GO:0044183 protein folding chaperone 6/784 75/18639 0.08 1.9019387755102 0.0954571600733104 0.474747046109283 GO:0051213 dioxygenase activity 7/784 93/18639 0.0752688172043011 1.78945852534562 0.0966728506707688 0.478249287709888 GO:0008307 structural constituent of muscle 4/784 42/18639 0.0952380952380952 2.26421282798834 0.0989628441227749 0.481552344269198 GO:0046982 protein heterodimerization activity 21/784 369/18639 0.0569105691056911 1.35300522648084 0.0997420991461675 0.481552344269198 GO:0005200 structural constituent of cytoskeleton 8/784 112/18639 0.0714285714285714 1.69815962099125 0.0997953570709931 0.481552344269198 GO:0043022 ribosome binding 8/784 112/18639 0.0714285714285714 1.69815962099125 0.0997953570709931 0.481552344269198 GO:0005172 vascular endothelial growth factor receptor binding 2/784 13/18639 0.153846153846154 3.65757456828885 0.101460761305917 0.481552344269198 GO:0008035 high-density lipoprotein particle binding 2/784 13/18639 0.153846153846154 3.65757456828885 0.101460761305917 0.481552344269198 GO:0071837 HMG box domain binding 2/784 13/18639 0.153846153846154 3.65757456828885 0.101460761305917 0.481552344269198 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 2/784 13/18639 0.153846153846154 3.65757456828885 0.101460761305917 0.481552344269198 GO:0001671 ATPase activator activity 3/784 27/18639 0.111111111111111 2.64158163265306 0.102810856057744 0.48305603223111 GO:0005044 scavenger receptor activity 3/784 27/18639 0.111111111111111 2.64158163265306 0.102810856057744 0.48305603223111 GO:0004714 transmembrane receptor protein tyrosine kinase activity 5/784 60/18639 0.0833333333333333 1.9811862244898 0.10734240768734 0.501825755938312 GO:0019789 SUMO transferase activity 3/784 28/18639 0.107142857142857 2.54723943148688 0.111728836454537 0.512882657494689 GO:0051393 alpha-actinin binding 3/784 28/18639 0.107142857142857 2.54723943148688 0.111728836454537 0.512882657494689 GO:0016790 thiolester hydrolase activity 4/784 44/18639 0.0909090909090909 2.16129406307978 0.112603521986482 0.512882657494689 GO:0030547 signaling receptor inhibitor activity 4/784 44/18639 0.0909090909090909 2.16129406307978 0.112603521986482 0.512882657494689 GO:0015026 coreceptor activity 5/784 61/18639 0.0819672131147541 1.94870776179324 0.113124522134583 0.512882657494689 GO:0019905 syntaxin binding 5/784 61/18639 0.0819672131147541 1.94870776179324 0.113124522134583 0.512882657494689 GO:0005161 platelet-derived growth factor receptor binding 2/784 14/18639 0.142857142857143 3.39631924198251 0.115192896335706 0.512882657494689 GO:0005545 1-phosphatidylinositol binding 2/784 14/18639 0.142857142857143 3.39631924198251 0.115192896335706 0.512882657494689 GO:0015926 glucosidase activity 2/784 14/18639 0.142857142857143 3.39631924198251 0.115192896335706 0.512882657494689 GO:0034236 protein kinase A catalytic subunit binding 2/784 14/18639 0.142857142857143 3.39631924198251 0.115192896335706 0.512882657494689 GO:0005125 cytokine activity 14/784 234/18639 0.0598290598290598 1.42239010989011 0.118210215209905 0.523650204682939 GO:0042626 ATPase-coupled transmembrane transporter activity 7/784 98/18639 0.0714285714285714 1.69815962099125 0.118731383307789 0.523650204682939 GO:0140303 intramembrane lipid transporter activity 4/784 45/18639 0.0888888888888889 2.11326530612245 0.119719209004075 0.525527983186901 GO:0051861 glycolipid binding 3/784 29/18639 0.103448275862069 2.45940358902182 0.120929789847061 0.528361464985991 GO:0043021 ribonucleoprotein complex binding 11/784 177/18639 0.0621468926553672 1.47749481148392 0.127394921165154 0.547294139263626 GO:0000774 adenyl-nucleotide exchange factor activity 2/784 15/18639 0.133333333333333 3.16989795918367 0.129360432916857 0.547294139263626 GO:0015929 hexosaminidase activity 2/784 15/18639 0.133333333333333 3.16989795918367 0.129360432916857 0.547294139263626 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/784 15/18639 0.133333333333333 3.16989795918367 0.129360432916857 0.547294139263626 GO:0050780 dopamine receptor binding 2/784 15/18639 0.133333333333333 3.16989795918367 0.129360432916857 0.547294139263626 GO:0051371 muscle alpha-actinin binding 2/784 15/18639 0.133333333333333 3.16989795918367 0.129360432916857 0.547294139263626 GO:0120283 protein serine/threonine kinase binding 2/784 15/18639 0.133333333333333 3.16989795918367 0.129360432916857 0.547294139263626 GO:0005319 lipid transporter activity 11/784 178/18639 0.0617977528089888 1.46919427883513 0.130968395743786 0.551601126218198 GO:0070851 growth factor receptor binding 9/784 139/18639 0.0647482014388489 1.53933893701365 0.131975854445239 0.55335167670986 GO:0043495 protein-membrane adaptor activity 4/784 47/18639 0.0851063829787234 2.0233391228832 0.134509270357677 0.561456106180482 GO:0005452 solute:inorganic anion antiporter activity 3/784 31/18639 0.0967741935483871 2.30073238973009 0.14011586355535 0.563509767281798 GO:0051117 ATPase binding 6/784 84/18639 0.0714285714285714 1.69815962099125 0.142076663185724 0.563509767281798 GO:0000062 fatty-acyl-CoA binding 2/784 16/18639 0.125 2.97177933673469 0.143902566781047 0.563509767281798 GO:0005024 transforming growth factor beta receptor activity 2/784 16/18639 0.125 2.97177933673469 0.143902566781047 0.563509767281798 GO:0008142 oxysterol binding 2/784 16/18639 0.125 2.97177933673469 0.143902566781047 0.563509767281798 GO:0019841 retinol binding 2/784 16/18639 0.125 2.97177933673469 0.143902566781047 0.563509767281798 GO:0022858 alanine transmembrane transporter activity 2/784 16/18639 0.125 2.97177933673469 0.143902566781047 0.563509767281798 GO:0034450 ubiquitin-ubiquitin ligase activity 2/784 16/18639 0.125 2.97177933673469 0.143902566781047 0.563509767281798 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/784 16/18639 0.125 2.97177933673469 0.143902566781047 0.563509767281798 GO:0020037 heme binding 9/784 142/18639 0.0633802816901408 1.50681769186548 0.144664778096447 0.563509767281798 GO:0005004 GPI-linked ephrin receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0005008 hepatocyte growth factor receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0005009 insulin receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0005011 macrophage colony-stimulating factor receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0005018 platelet-derived growth factor alpha-receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0005020 stem cell factor receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0008288 boss receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0036332 placental growth factor receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0038062 protein tyrosine kinase collagen receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0060175 brain-derived neurotrophic factor receptor activity 4/784 49/18639 0.0816326530612245 1.94075385256143 0.149998865151643 0.563509767281798 GO:0042910 xenobiotic transmembrane transporter activity 3/784 32/18639 0.09375 2.22883450255102 0.150068376527452 0.563509767281798 GO:0043425 bHLH transcription factor binding 3/784 32/18639 0.09375 2.22883450255102 0.150068376527452 0.563509767281798 GO:0071813 lipoprotein particle binding 3/784 32/18639 0.09375 2.22883450255102 0.150068376527452 0.563509767281798 GO:0071814 protein-lipid complex binding 3/784 32/18639 0.09375 2.22883450255102 0.150068376527452 0.563509767281798 GO:0120015 sterol transfer activity 3/784 32/18639 0.09375 2.22883450255102 0.150068376527452 0.563509767281798 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 5/784 67/18639 0.0746268656716418 1.77419661894609 0.150772102102776 0.563887661864383 GO:0061135 endopeptidase regulator activity 11/784 184/18639 0.0597826086956522 1.42128576974268 0.153531460379221 0.564820573179701 GO:0030145 manganese ion binding 5/784 68/18639 0.0735294117647059 1.74810549219688 0.157505707497125 0.564820573179701 GO:0005006 epidermal growth factor receptor activity 4/784 50/18639 0.08 1.9019387755102 0.157988270730811 0.564820573179701 GO:0005007 fibroblast growth factor receptor activity 4/784 50/18639 0.08 1.9019387755102 0.157988270730811 0.564820573179701 GO:0005017 platelet-derived growth factor receptor activity 4/784 50/18639 0.08 1.9019387755102 0.157988270730811 0.564820573179701 GO:0005019 platelet-derived growth factor beta-receptor activity 4/784 50/18639 0.08 1.9019387755102 0.157988270730811 0.564820573179701 GO:0004550 nucleoside diphosphate kinase activity 2/784 17/18639 0.117647058823529 2.79696878751501 0.158762826905039 0.564820573179701 GO:0030169 low-density lipoprotein particle binding 2/784 17/18639 0.117647058823529 2.79696878751501 0.158762826905039 0.564820573179701 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 2/784 17/18639 0.117647058823529 2.79696878751501 0.158762826905039 0.564820573179701 GO:0030548 acetylcholine receptor regulator activity 2/784 17/18639 0.117647058823529 2.79696878751501 0.158762826905039 0.564820573179701 GO:1901567 fatty acid derivative binding 2/784 17/18639 0.117647058823529 2.79696878751501 0.158762826905039 0.564820573179701 GO:1990226 histone methyltransferase binding 2/784 17/18639 0.117647058823529 2.79696878751501 0.158762826905039 0.564820573179701 GO:0008013 beta-catenin binding 7/784 106/18639 0.0660377358490566 1.56999663072776 0.158874663899745 0.564820573179701 GO:0005021 vascular endothelial growth factor receptor activity 4/784 51/18639 0.0784313725490196 1.86464585834334 0.166131002359983 0.582436909510827 GO:0005030 neurotrophin receptor activity 4/784 51/18639 0.0784313725490196 1.86464585834334 0.166131002359983 0.582436909510827 GO:0016830 carbon-carbon lyase activity 4/784 51/18639 0.0784313725490196 1.86464585834334 0.166131002359983 0.582436909510827 GO:0016247 channel regulator activity 10/784 168/18639 0.0595238095238095 1.41513301749271 0.171041269550885 0.582436909510827 GO:0031490 chromatin DNA binding 8/784 128/18639 0.0625 1.48588966836735 0.17153995876091 0.582436909510827 GO:0051015 actin filament binding 12/784 209/18639 0.0574162679425837 1.36502782931354 0.171596453052592 0.582436909510827 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 2/784 18/18639 0.111111111111111 2.64158163265306 0.173888819314568 0.582436909510827 GO:0017075 syntaxin-1 binding 2/784 18/18639 0.111111111111111 2.64158163265306 0.173888819314568 0.582436909510827 GO:0017128 phospholipid scramblase activity 2/784 18/18639 0.111111111111111 2.64158163265306 0.173888819314568 0.582436909510827 GO:0031690 adrenergic receptor binding 2/784 18/18639 0.111111111111111 2.64158163265306 0.173888819314568 0.582436909510827 GO:0034185 apolipoprotein binding 2/784 18/18639 0.111111111111111 2.64158163265306 0.173888819314568 0.582436909510827 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 2/784 18/18639 0.111111111111111 2.64158163265306 0.173888819314568 0.582436909510827 GO:0070064 proline-rich region binding 2/784 18/18639 0.111111111111111 2.64158163265306 0.173888819314568 0.582436909510827 GO:0099602 neurotransmitter receptor regulator activity 2/784 18/18639 0.111111111111111 2.64158163265306 0.173888819314568 0.582436909510827 GO:1990381 ubiquitin-specific protease binding 2/784 18/18639 0.111111111111111 2.64158163265306 0.173888819314568 0.582436909510827 GO:0005525 GTP binding 20/784 378/18639 0.0529100529100529 1.25789601554908 0.173971824071519 0.582436909510827 GO:0005080 protein kinase C binding 4/784 52/18639 0.0769230769230769 1.82878728414443 0.174419609265274 0.582436909510827 GO:0019902 phosphatase binding 11/784 190/18639 0.0578947368421053 1.37640306122449 0.177938142734254 0.59207175607305 GO:0141108 transporter regulator activity 10/784 170/18639 0.0588235294117647 1.3984843937575 0.179929965628777 0.593616424249612 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 8/784 130/18639 0.0615384615384615 1.46302982731554 0.181834883098154 0.593616424249612 GO:0005003 ephrin receptor activity 4/784 53/18639 0.0754716981132075 1.79428186368887 0.182846556346405 0.593616424249612 GO:0005005 transmembrane-ephrin receptor activity 4/784 53/18639 0.0754716981132075 1.79428186368887 0.182846556346405 0.593616424249612 GO:0017046 peptide hormone binding 4/784 53/18639 0.0754716981132075 1.79428186368887 0.182846556346405 0.593616424249612 GO:0038064 collagen receptor activity 4/784 53/18639 0.0754716981132075 1.79428186368887 0.182846556346405 0.593616424249612 GO:0051018 protein kinase A binding 4/784 53/18639 0.0754716981132075 1.79428186368887 0.182846556346405 0.593616424249612 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 2/784 19/18639 0.105263157894737 2.50255102040816 0.189231984730859 0.603863159465369 GO:0030506 ankyrin binding 2/784 19/18639 0.105263157894737 2.50255102040816 0.189231984730859 0.603863159465369 GO:0043395 heparan sulfate proteoglycan binding 2/784 19/18639 0.105263157894737 2.50255102040816 0.189231984730859 0.603863159465369 GO:0097001 ceramide binding 2/784 19/18639 0.105263157894737 2.50255102040816 0.189231984730859 0.603863159465369 GO:0120227 acyl-CoA binding 2/784 19/18639 0.105263157894737 2.50255102040816 0.189231984730859 0.603863159465369 GO:0046906 tetrapyrrole binding 9/784 152/18639 0.0592105263157895 1.40768494897959 0.191091430026995 0.605674932232014 GO:0015485 cholesterol binding 4/784 54/18639 0.0740740740740741 1.76105442176871 0.191404246699908 0.605674932232014 GO:0005484 SNAP receptor activity 3/784 36/18639 0.0833333333333333 1.9811862244898 0.191896252868216 0.605674932232014 GO:0005179 hormone activity 8/784 132/18639 0.0606060606060606 1.44086270871985 0.19239086082664 0.605674932232014 GO:0019213 deacetylase activity 3/784 37/18639 0.0810810810810811 1.92764065085494 0.202777980315238 0.634105055500828 GO:0042805 actinin binding 3/784 37/18639 0.0810810810810811 1.92764065085494 0.202777980315238 0.634105055500828 GO:0005543 phospholipid binding 25/784 497/18639 0.0503018108651912 1.19588705703609 0.204427124292293 0.637131204044312 GO:0001221 transcription coregulator binding 7/784 115/18639 0.0608695652173913 1.44712732919255 0.21030096369003 0.651346685101755 GO:0004867 serine-type endopeptidase inhibitor activity 6/784 95/18639 0.0631578947368421 1.5015306122449 0.210381496150513 0.651346685101755 GO:0072542 protein phosphatase activator activity 2/784 21/18639 0.0952380952380952 2.26421282798834 0.220393408086893 0.680091869839093 GO:0016776 phosphotransferase activity, phosphate group as acceptor 3/784 39/18639 0.0769230769230769 1.82878728414443 0.224942941658759 0.689579181806359 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 3/784 39/18639 0.0769230769230769 1.82878728414443 0.224942941658759 0.689579181806359 GO:0003924 GTPase activity 17/784 331/18639 0.0513595166163142 1.22103320180036 0.231906305785629 0.707408082035925 GO:0099106 ion channel regulator activity 9/784 160/18639 0.05625 1.33730070153061 0.232271958486662 0.707408082035925 GO:0004407 histone deacetylase activity 2/784 22/18639 0.0909090909090909 2.16129406307978 0.236131719626359 0.708036552993427 GO:0033558 protein lysine deacetylase activity 2/784 22/18639 0.0909090909090909 2.16129406307978 0.236131719626359 0.708036552993427 GO:0061133 endopeptidase activator activity 2/784 22/18639 0.0909090909090909 2.16129406307978 0.236131719626359 0.708036552993427 GO:0004713 protein tyrosine kinase activity 8/784 140/18639 0.0571428571428571 1.358527696793 0.236974602891431 0.708036552993427 GO:0004866 endopeptidase inhibitor activity 9/784 161/18639 0.0559006211180124 1.32899448599316 0.237636771023414 0.708036552993427 GO:0015370 solute:sodium symporter activity 5/784 79/18639 0.0632911392405063 1.50469839834668 0.238588836264127 0.708036552993427 GO:0008083 growth factor activity 9/784 162/18639 0.0555555555555556 1.32079081632653 0.243045321693611 0.708036552993427 GO:0019001 guanyl nucleotide binding 20/784 400/18639 0.05 1.18871173469388 0.243869699749717 0.708036552993427 GO:0032561 guanyl ribonucleotide binding 20/784 400/18639 0.05 1.18871173469388 0.243869699749717 0.708036552993427 GO:0048306 calcium-dependent protein binding 5/784 80/18639 0.0625 1.48588966836735 0.246480485195468 0.708036552993427 GO:0015175 neutral L-amino acid transmembrane transporter activity 3/784 41/18639 0.0731707317073171 1.7395781483325 0.24754491831041 0.708036552993427 GO:0017080 sodium channel regulator activity 3/784 41/18639 0.0731707317073171 1.7395781483325 0.24754491831041 0.708036552993427 GO:0140318 protein transporter activity 3/784 41/18639 0.0731707317073171 1.7395781483325 0.24754491831041 0.708036552993427 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 2/784 23/18639 0.0869565217391304 2.06732475598935 0.251926912700636 0.708036552993427 GO:0005158 insulin receptor binding 2/784 23/18639 0.0869565217391304 2.06732475598935 0.251926912700636 0.708036552993427 GO:0005212 structural constituent of eye lens 2/784 23/18639 0.0869565217391304 2.06732475598935 0.251926912700636 0.708036552993427 GO:0008171 O-methyltransferase activity 2/784 23/18639 0.0869565217391304 2.06732475598935 0.251926912700636 0.708036552993427 GO:0017134 fibroblast growth factor binding 2/784 23/18639 0.0869565217391304 2.06732475598935 0.251926912700636 0.708036552993427 GO:0031681 G-protein beta-subunit binding 2/784 23/18639 0.0869565217391304 2.06732475598935 0.251926912700636 0.708036552993427 GO:0051020 GTPase binding 16/784 315/18639 0.0507936507936508 1.20758017492711 0.253967651123234 0.708036552993427 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7/784 122/18639 0.0573770491803279 1.36409543325527 0.253996940393885 0.708036552993427 GO:0033192 calmodulin-dependent protein phosphatase activity 5/784 81/18639 0.0617283950617284 1.46754535147392 0.254438804070365 0.708036552993427 GO:0140791 histone H2AXS140 phosphatase activity 5/784 81/18639 0.0617283950617284 1.46754535147392 0.254438804070365 0.708036552993427 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 5/784 81/18639 0.0617283950617284 1.46754535147392 0.254438804070365 0.708036552993427 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 5/784 81/18639 0.0617283950617284 1.46754535147392 0.254438804070365 0.708036552993427 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 5/784 81/18639 0.0617283950617284 1.46754535147392 0.254438804070365 0.708036552993427 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 5/784 81/18639 0.0617283950617284 1.46754535147392 0.254438804070365 0.708036552993427 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 5/784 81/18639 0.0617283950617284 1.46754535147392 0.254438804070365 0.708036552993427 GO:1990439 MAP kinase serine/threonine phosphatase activity 5/784 81/18639 0.0617283950617284 1.46754535147392 0.254438804070365 0.708036552993427 GO:0016859 cis-trans isomerase activity 3/784 42/18639 0.0714285714285714 1.69815962099125 0.258974308632536 0.714280172777053 GO:0031492 nucleosomal DNA binding 3/784 42/18639 0.0714285714285714 1.69815962099125 0.258974308632536 0.714280172777053 GO:0048487 beta-tubulin binding 3/784 42/18639 0.0714285714285714 1.69815962099125 0.258974308632536 0.714280172777053 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 5/784 82/18639 0.0609756097560976 1.44964845694375 0.262459125794899 0.719645990082789 GO:0033549 MAP kinase phosphatase activity 5/784 82/18639 0.0609756097560976 1.44964845694375 0.262459125794899 0.719645990082789 GO:0015179 L-amino acid transmembrane transporter activity 4/784 62/18639 0.0645161290322581 1.53382159315339 0.263656366010663 0.72081491877184 GO:0005540 hyaluronic acid binding 2/784 24/18639 0.0833333333333333 1.9811862244898 0.267746402986591 0.723534354891509 GO:0015149 hexose transmembrane transporter activity 2/784 24/18639 0.0833333333333333 1.9811862244898 0.267746402986591 0.723534354891509 GO:0050699 WW domain binding 2/784 24/18639 0.0833333333333333 1.9811862244898 0.267746402986591 0.723534354891509 GO:0055056 D-glucose transmembrane transporter activity 2/784 24/18639 0.0833333333333333 1.9811862244898 0.267746402986591 0.723534354891509 GO:0048156 tau protein binding 3/784 43/18639 0.0697674418604651 1.65866753678215 0.27047118011062 0.726873290889724 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 5/784 83/18639 0.0602409638554217 1.43218281288419 0.270536797037031 0.726873290889724 GO:1901682 sulfur compound transmembrane transporter activity 4/784 63/18639 0.0634920634920635 1.50947521865889 0.27304835991664 0.731519245048879 GO:0017018 myosin phosphatase activity 5/784 84/18639 0.0595238095238095 1.41513301749271 0.278667185255468 0.742657771663225 GO:0030414 peptidase inhibitor activity 9/784 169/18639 0.0532544378698225 1.26608350440768 0.282009031250807 0.742657771663225 GO:0001046 core promoter sequence-specific DNA binding 3/784 44/18639 0.0681818181818182 1.62097054730983 0.282022472168484 0.742657771663225 GO:0001848 complement binding 2/784 25/18639 0.08 1.9019387755102 0.283560240089595 0.742657771663225 GO:0004709 MAP kinase kinase kinase activity 2/784 25/18639 0.08 1.9019387755102 0.283560240089595 0.742657771663225 GO:0015645 fatty acid ligase activity 2/784 25/18639 0.08 1.9019387755102 0.283560240089595 0.742657771663225 GO:0120020 cholesterol transfer activity 2/784 25/18639 0.08 1.9019387755102 0.283560240089595 0.742657771663225 GO:0120515 fatty acid-CoA ligase activity 2/784 25/18639 0.08 1.9019387755102 0.283560240089595 0.742657771663225 GO:0000149 SNARE binding 6/784 106/18639 0.0566037735849057 1.34571139776665 0.287698975225415 0.749299559431094 GO:0004497 monooxygenase activity 6/784 106/18639 0.0566037735849057 1.34571139776665 0.287698975225415 0.749299559431094 GO:0019843 rRNA binding 4/784 65/18639 0.0615384615384615 1.46302982731554 0.291991778841443 0.756266795614264 GO:0160215 deacylase activity 4/784 65/18639 0.0615384615384615 1.46302982731554 0.291991778841443 0.756266795614264 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 7/784 128/18639 0.0546875 1.30015345982143 0.293376572341953 0.756282509197989 GO:0042605 peptide antigen binding 3/784 45/18639 0.0666666666666667 1.58494897959184 0.293615562394513 0.756282509197989 GO:0008157 protein phosphatase 1 binding 2/784 26/18639 0.0769230769230769 1.82878728414443 0.299340944085959 0.761206834805332 GO:0008198 ferrous iron binding 2/784 26/18639 0.0769230769230769 1.82878728414443 0.299340944085959 0.761206834805332 GO:0015145 monosaccharide transmembrane transporter activity 2/784 26/18639 0.0769230769230769 1.82878728414443 0.299340944085959 0.761206834805332 GO:0030276 clathrin binding 3/784 46/18639 0.0652173913043478 1.55049356699201 0.305238275433768 0.761206834805332 GO:0004197 cysteine-type endopeptidase activity 5/784 88/18639 0.0568181818181818 1.35080878942486 0.311624350062301 0.761206834805332 GO:0031072 heat shock protein binding 7/784 131/18639 0.0534351145038168 1.27037895310796 0.313561298108739 0.761206834805332 GO:0004364 glutathione transferase activity 2/784 27/18639 0.0740740740740741 1.76105442176871 0.315063351128216 0.761206834805332 GO:0008320 protein transmembrane transporter activity 2/784 27/18639 0.0740740740740741 1.76105442176871 0.315063351128216 0.761206834805332 GO:0015252 proton channel activity 2/784 27/18639 0.0740740740740741 1.76105442176871 0.315063351128216 0.761206834805332 GO:0016405 CoA-ligase activity 2/784 27/18639 0.0740740740740741 1.76105442176871 0.315063351128216 0.761206834805332 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 2/784 27/18639 0.0740740740740741 1.76105442176871 0.315063351128216 0.761206834805332 GO:0140359 ABC-type transporter activity 3/784 47/18639 0.0638297872340425 1.5175043421624 0.316878889416228 0.761206834805332 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 7/784 132/18639 0.053030303030303 1.26075487012987 0.320346842596536 0.761206834805332 GO:0016866 intramolecular transferase activity 2/784 28/18639 0.0714285714285714 1.69815962099125 0.330704467641576 0.761206834805332 GO:0046625 sphingolipid binding 2/784 28/18639 0.0714285714285714 1.69815962099125 0.330704467641576 0.761206834805332 GO:0051119 sugar transmembrane transporter activity 2/784 28/18639 0.0714285714285714 1.69815962099125 0.330704467641576 0.761206834805332 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 2/784 28/18639 0.0714285714285714 1.69815962099125 0.330704467641576 0.761206834805332 GO:0016829 lyase activity 10/784 200/18639 0.05 1.18871173469388 0.33357151523694 0.761206834805332 GO:0072341 modified amino acid binding 5/784 91/18639 0.0549450549450549 1.30627663153173 0.336674147438892 0.761206834805332 GO:0097110 scaffold protein binding 4/784 70/18639 0.0571428571428571 1.358527696793 0.339957436275328 0.761206834805332 GO:0016763 pentosyltransferase activity 3/784 49/18639 0.0612244897959184 1.45556538942107 0.340169223303662 0.761206834805332 GO:0015297 antiporter activity 7/784 135/18639 0.0518518518518519 1.2327380952381 0.340842019316847 0.761206834805332 GO:0008514 organic anion transmembrane transporter activity 13/784 269/18639 0.0483271375464684 1.14894071011304 0.343895726537386 0.761206834805332 GO:0003785 actin monomer binding 2/784 29/18639 0.0689655172413793 1.63960239268121 0.346243332663392 0.761206834805332 GO:0004629 phospholipase C activity 2/784 29/18639 0.0689655172413793 1.63960239268121 0.346243332663392 0.761206834805332 GO:0016417 S-acyltransferase activity 2/784 29/18639 0.0689655172413793 1.63960239268121 0.346243332663392 0.761206834805332 GO:0106222 lncRNA binding 2/784 29/18639 0.0689655172413793 1.63960239268121 0.346243332663392 0.761206834805332 GO:0140789 histone phosphatase activity 7/784 136/18639 0.0514705882352941 1.22367384453782 0.347712064076433 0.761206834805332 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0004090 carbonyl reductase (NADPH) activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0004862 cAMP-dependent protein kinase inhibitor activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0004935 adrenergic receptor activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0005522 profilin binding 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0008140 cAMP response element binding protein binding 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0008401 retinoic acid 4-hydroxylase activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0015187 glycine transmembrane transporter activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0015203 polyamine transmembrane transporter activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0015643 toxic substance binding 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0016303 1-phosphatidylinositol-3-kinase activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0016868 intramolecular phosphotransferase activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0019531 oxalate transmembrane transporter activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0019911 structural constituent of myelin sheath 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0043208 glycosphingolipid binding 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0043295 glutathione binding 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0047429 nucleoside triphosphate diphosphatase activity 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0070097 delta-catenin binding 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0070513 death domain binding 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0097177 mitochondrial ribosome binding 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 1/784 10/18639 0.1 2.37742346938776 0.349381502359207 0.761206834805332 GO:0016922 nuclear receptor binding 7/784 137/18639 0.0510948905109489 1.21474191866528 0.354597377569689 0.761206834805332 GO:0017124 SH3 domain binding 6/784 115/18639 0.0521739130434783 1.24039485359361 0.354732808377951 0.761206834805332 GO:0035401 histone H3Y41 kinase activity 6/784 115/18639 0.0521739130434783 1.24039485359361 0.354732808377951 0.761206834805332 GO:0140801 histone H2AXY142 kinase activity 6/784 115/18639 0.0521739130434783 1.24039485359361 0.354732808377951 0.761206834805332 GO:0001965 G-protein alpha-subunit binding 2/784 30/18639 0.0666666666666667 1.58494897959184 0.361660887899938 0.761206834805332 GO:0008106 alcohol dehydrogenase (NADP+) activity 2/784 30/18639 0.0666666666666667 1.58494897959184 0.361660887899938 0.761206834805332 GO:0031210 phosphatidylcholine binding 2/784 30/18639 0.0666666666666667 1.58494897959184 0.361660887899938 0.761206834805332 GO:0048019 receptor antagonist activity 2/784 30/18639 0.0666666666666667 1.58494897959184 0.361660887899938 0.761206834805332 GO:0051721 protein phosphatase 2A binding 2/784 30/18639 0.0666666666666667 1.58494897959184 0.361660887899938 0.761206834805332 GO:0015294 solute:monoatomic cation symporter activity 6/784 116/18639 0.0517241379310345 1.22970179451091 0.362280032173613 0.761206834805332 GO:0003743 translation initiation factor activity 3/784 51/18639 0.0588235294117647 1.3984843937575 0.363401969268514 0.761206834805332 GO:0030544 Hsp70 protein binding 3/784 51/18639 0.0588235294117647 1.3984843937575 0.363401969268514 0.761206834805332 GO:0043539 protein serine/threonine kinase activator activity 4/784 73/18639 0.0547945205479452 1.30269779144535 0.368892043972607 0.761206834805332 GO:1990782 protein tyrosine kinase binding 6/784 117/18639 0.0512820512820513 1.21919152276295 0.369835944596816 0.761206834805332 GO:0005516 calmodulin binding 10/784 207/18639 0.0483091787439614 1.14851375332742 0.372929193084664 0.761206834805332 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0002162 dystroglycan binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0005225 volume-sensitive anion channel activity 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0008199 ferric iron binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0008271 secondary active sulfate transmembrane transporter activity 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0008432 JUN kinase binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0015173 aromatic amino acid transmembrane transporter activity 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0016594 glycine binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0042608 T cell receptor binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0043522 leucine zipper domain binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0047676 arachidonate-CoA ligase activity 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0048185 activin binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0050998 nitric-oxide synthase binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0070697 activin receptor binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0070990 snRNP binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0098973 structural constituent of postsynaptic actin cytoskeleton 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0140031 phosphorylation-dependent protein binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:1900750 oligopeptide binding 1/784 11/18639 0.0909090909090909 2.16129406307978 0.376762730667241 0.761206834805332 GO:0005164 tumor necrosis factor receptor binding 2/784 31/18639 0.0645161290322581 1.53382159315339 0.376939855096116 0.761206834805332 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/784 31/18639 0.0645161290322581 1.53382159315339 0.376939855096116 0.761206834805332 GO:0016411 acylglycerol O-acyltransferase activity 2/784 31/18639 0.0645161290322581 1.53382159315339 0.376939855096116 0.761206834805332 GO:0016878 acid-thiol ligase activity 2/784 31/18639 0.0645161290322581 1.53382159315339 0.376939855096116 0.761206834805332 GO:0047499 calcium-independent phospholipase A2 activity 2/784 31/18639 0.0645161290322581 1.53382159315339 0.376939855096116 0.761206834805332 GO:0005544 calcium-dependent phospholipid binding 3/784 53/18639 0.0566037735849057 1.34571139776665 0.386499863529764 0.762462614271118 GO:0008146 sulfotransferase activity 3/784 53/18639 0.0566037735849057 1.34571139776665 0.386499863529764 0.762462614271118 GO:0015106 bicarbonate transmembrane transporter activity 2/784 32/18639 0.0625 1.48588966836735 0.392064620334027 0.762462614271118 GO:0022884 macromolecule transmembrane transporter activity 2/784 32/18639 0.0625 1.48588966836735 0.392064620334027 0.762462614271118 GO:0047498 calcium-dependent phospholipase A2 activity 2/784 32/18639 0.0625 1.48588966836735 0.392064620334027 0.762462614271118 GO:0015103 inorganic anion transmembrane transporter activity 8/784 165/18639 0.0484848484848485 1.15269016697588 0.392103189680591 0.762462614271118 GO:0046943 carboxylic acid transmembrane transporter activity 9/784 188/18639 0.0478723404255319 1.1381282566218 0.394174208935591 0.762462614271118 GO:0051287 NAD binding 3/784 54/18639 0.0555555555555556 1.32079081632653 0.397976076284462 0.762462614271118 GO:0140463 chromatin-protein adaptor activity 3/784 54/18639 0.0555555555555556 1.32079081632653 0.397976076284462 0.762462614271118 GO:0015108 chloride transmembrane transporter activity 6/784 121/18639 0.0495867768595041 1.17888767077079 0.400088766080141 0.762462614271118 GO:0005342 organic acid transmembrane transporter activity 9/784 189/18639 0.0476190476190476 1.13210641399417 0.400201182908572 0.762462614271118 GO:0004000 adenosine deaminase activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0004126 cytidine deaminase activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0005078 MAP-kinase scaffold activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0005436 sodium:phosphate symporter activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0008504 monoamine transmembrane transporter activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0008603 cAMP-dependent protein kinase regulator activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0015132 prostaglandin transmembrane transporter activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0015166 polyol transmembrane transporter activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0016840 carbon-nitrogen lyase activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0045295 gamma-catenin binding 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0070008 serine-type exopeptidase activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0070410 co-SMAD binding 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0070679 inositol 1,4,5 trisphosphate binding 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0140829 bicarbonate:monoatomic anion antiporter activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0140900 chloride:bicarbonate antiporter activity 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0141221 histone deacetylase activity, hydrolytic mechanism 1/784 12/18639 0.0833333333333333 1.9811862244898 0.402993030171047 0.762462614271118 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 2/784 33/18639 0.0606060606060606 1.44086270871985 0.40702112489562 0.762462614271118 GO:0019239 deaminase activity 2/784 33/18639 0.0606060606060606 1.44086270871985 0.40702112489562 0.762462614271118 GO:0071889 14-3-3 protein binding 2/784 33/18639 0.0606060606060606 1.44086270871985 0.40702112489562 0.762462614271118 GO:0140311 protein sequestering activity 2/784 33/18639 0.0606060606060606 1.44086270871985 0.40702112489562 0.762462614271118 GO:0008374 O-acyltransferase activity 3/784 55/18639 0.0545454545454545 1.29677643784787 0.409392866667288 0.762462614271118 GO:0098632 cell-cell adhesion mediator activity 3/784 55/18639 0.0545454545454545 1.29677643784787 0.409392866667288 0.762462614271118 GO:0031267 small GTPase binding 13/784 283/18639 0.0459363957597173 1.09210265378236 0.412632787376386 0.762462614271118 GO:0170055 lipid transmembrane transporter activity 3/784 56/18639 0.0535714285714286 1.27361971574344 0.42074257868899 0.762462614271118 GO:0008376 acetylgalactosaminyltransferase activity 2/784 34/18639 0.0588235294117647 1.3984843937575 0.421796762343037 0.762462614271118 GO:0015020 glucuronosyltransferase activity 2/784 34/18639 0.0588235294117647 1.3984843937575 0.421796762343037 0.762462614271118 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/784 34/18639 0.0588235294117647 1.3984843937575 0.421796762343037 0.762462614271118 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/784 34/18639 0.0588235294117647 1.3984843937575 0.421796762343037 0.762462614271118 GO:0016831 carboxy-lyase activity 2/784 34/18639 0.0588235294117647 1.3984843937575 0.421796762343037 0.762462614271118 GO:0051427 hormone receptor binding 2/784 34/18639 0.0588235294117647 1.3984843937575 0.421796762343037 0.762462614271118 GO:0090482 vitamin transmembrane transporter activity 2/784 34/18639 0.0588235294117647 1.3984843937575 0.421796762343037 0.762462614271118 GO:0004465 lipoprotein lipase activity 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0005542 folic acid binding 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0017154 semaphorin receptor activity 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0030955 potassium ion binding 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0035673 oligopeptide transmembrane transporter activity 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0039706 co-receptor binding 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0043560 insulin receptor substrate binding 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0045159 myosin II binding 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0061459 L-arginine transmembrane transporter activity 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0071714 icosanoid transmembrane transporter activity 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0089720 caspase binding 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0097157 pre-mRNA intronic binding 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 1/784 13/18639 0.0769230769230769 1.82878728414443 0.428120719243141 0.762462614271118 GO:0015291 secondary active transmembrane transporter activity 13/784 287/18639 0.0452961672473868 1.0768817108725 0.4324423869312 0.765941312265723 GO:0004623 phospholipase A2 activity 2/784 35/18639 0.0571428571428571 1.358527696793 0.436380281487713 0.765941312265723 GO:0005154 epidermal growth factor receptor binding 2/784 35/18639 0.0571428571428571 1.358527696793 0.436380281487713 0.765941312265723 GO:0005343 organic acid:sodium symporter activity 2/784 35/18639 0.0571428571428571 1.358527696793 0.436380281487713 0.765941312265723 GO:0004722 protein serine/threonine phosphatase activity 5/784 103/18639 0.0485436893203883 1.15408906280959 0.437343583400519 0.765941312265723 GO:0008509 monoatomic anion transmembrane transporter activity 7/784 149/18639 0.0469798657718121 1.11691035474593 0.437597213866756 0.765941312265723 GO:0003823 antigen binding 8/784 174/18639 0.0459770114942529 1.09306826178747 0.449881468849535 0.765941312265723 GO:0004033 aldo-keto reductase (NADPH) activity 2/784 36/18639 0.0555555555555556 1.32079081632653 0.450761694935918 0.765941312265723 GO:0004869 cysteine-type endopeptidase inhibitor activity 2/784 36/18639 0.0555555555555556 1.32079081632653 0.450761694935918 0.765941312265723 GO:0016409 palmitoyltransferase activity 2/784 36/18639 0.0555555555555556 1.32079081632653 0.450761694935918 0.765941312265723 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 2/784 36/18639 0.0555555555555556 1.32079081632653 0.450761694935918 0.765941312265723 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 2/784 36/18639 0.0555555555555556 1.32079081632653 0.450761694935918 0.765941312265723 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 2/784 36/18639 0.0555555555555556 1.32079081632653 0.450761694935918 0.765941312265723 GO:0008392 arachidonate epoxygenase activity 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0008474 palmitoyl-(protein) hydrolase activity 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0008559 ABC-type xenobiotic transporter activity 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0015386 potassium:proton antiporter activity 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0032036 myosin heavy chain binding 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0042043 neurexin family protein binding 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0061665 SUMO ligase activity 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0071933 Arp2/3 complex binding 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0098599 palmitoyl hydrolase activity 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0098847 sequence-specific single stranded DNA binding 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:1901474 azole transmembrane transporter activity 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:1901612 cardiolipin binding 1/784 14/18639 0.0714285714285714 1.69815962099125 0.452192090236021 0.765941312265723 GO:0015459 potassium channel regulator activity 3/784 59/18639 0.0508474576271186 1.20885939121411 0.454319014488068 0.766765845751522 GO:0036002 pre-mRNA binding 3/784 59/18639 0.0508474576271186 1.20885939121411 0.454319014488068 0.766765845751522 GO:0008135 translation factor activity, RNA binding 4/784 83/18639 0.0481927710843374 1.14574625030735 0.463956648038723 0.779579205611896 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/784 60/18639 0.05 1.18871173469388 0.465332229669528 0.779579205611896 GO:0016298 lipase activity 6/784 130/18639 0.0461538461538462 1.09727237048666 0.467590588052808 0.779579205611896 GO:0180051 translation factor activity 4/784 84/18639 0.0476190476190476 1.13210641399417 0.473221121177886 0.779579205611896 GO:0004089 carbonate dehydratase activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0004467 long-chain fatty acid-CoA ligase activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0004559 alpha-mannosidase activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0005402 carbohydrate:monoatomic cation symporter activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0005523 tropomyosin binding 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0008020 G protein-coupled photoreceptor activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0015116 sulfate transmembrane transporter activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0031005 filamin binding 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0140161 monocarboxylate:sodium symporter activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0141050 histone H3K deacetylase activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0141051 histone H4K deacetylase activity 1/784 15/18639 0.0666666666666667 1.58494897959184 0.475251494330247 0.779579205611896 GO:0000146 microfilament motor activity 2/784 38/18639 0.0526315789473684 1.25127551020408 0.478884062093526 0.781425127499906 GO:0042887 amide transmembrane transporter activity 2/784 38/18639 0.0526315789473684 1.25127551020408 0.478884062093526 0.781425127499906 GO:0043531 ADP binding 2/784 38/18639 0.0526315789473684 1.25127551020408 0.478884062093526 0.781425127499906 GO:0004620 phospholipase activity 5/784 109/18639 0.0458715596330275 1.0905612244898 0.486576034072943 0.789497844396176 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 2/784 39/18639 0.0512820512820513 1.21919152276295 0.492610609144054 0.789497844396176 GO:0004222 metalloendopeptidase activity 5/784 110/18639 0.0454545454545455 1.08064703153989 0.494640037707413 0.789497844396176 GO:0005149 interleukin-1 receptor binding 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0008391 arachidonate monooxygenase activity 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0015378 sodium:chloride symporter activity 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0015562 efflux transmembrane transporter activity 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0015923 mannosidase activity 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0016722 oxidoreductase activity, acting on metal ions 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0017070 U6 snRNA binding 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0030275 LRR domain binding 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0043023 ribosomal large subunit binding 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0070411 I-SMAD binding 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0140327 flippase activity 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0140328 floppase activity 1/784 16/18639 0.0625 1.48588966836735 0.497341422833527 0.789497844396176 GO:0005085 guanyl-nucleotide exchange factor activity 10/784 230/18639 0.0434782608695652 1.03366237799468 0.503103643665556 0.79264521440281 GO:0004177 aminopeptidase activity 2/784 40/18639 0.05 1.18871173469388 0.506106088768425 0.79264521440281 GO:0015144 carbohydrate transmembrane transporter activity 2/784 40/18639 0.05 1.18871173469388 0.506106088768425 0.79264521440281 GO:0030331 nuclear estrogen receptor binding 2/784 40/18639 0.05 1.18871173469388 0.506106088768425 0.79264521440281 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 2/784 40/18639 0.05 1.18871173469388 0.506106088768425 0.79264521440281 GO:0050997 quaternary ammonium group binding 2/784 40/18639 0.05 1.18871173469388 0.506106088768425 0.79264521440281 GO:0071855 neuropeptide receptor binding 2/784 40/18639 0.05 1.18871173469388 0.506106088768425 0.79264521440281 GO:0140662 ATP-dependent protein folding chaperone 2/784 40/18639 0.05 1.18871173469388 0.506106088768425 0.79264521440281 GO:0004029 aldehyde dehydrogenase (NAD+) activity 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0009881 photoreceptor activity 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0017110 nucleoside diphosphate phosphatase activity 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0019198 transmembrane receptor protein phosphatase activity 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0070403 NAD+ binding 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0070492 oligosaccharide binding 1/784 17/18639 0.0588235294117647 1.3984843937575 0.518502585079057 0.793475277178529 GO:0120013 lipid transfer activity 3/784 65/18639 0.0461538461538462 1.09727237048666 0.518811506286496 0.793475277178529 GO:0001530 lipopolysaccharide binding 2/784 41/18639 0.0487804878048781 1.159718765555 0.519365635971401 0.793475277178529 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 2/784 41/18639 0.0487804878048781 1.159718765555 0.519365635971401 0.793475277178529 GO:0016877 ligase activity, forming carbon-sulfur bonds 2/784 41/18639 0.0487804878048781 1.159718765555 0.519365635971401 0.793475277178529 GO:0042169 SH2 domain binding 2/784 41/18639 0.0487804878048781 1.159718765555 0.519365635971401 0.793475277178529 GO:0035198 miRNA binding 2/784 42/18639 0.0476190476190476 1.13210641399417 0.532385202338344 0.804718329338603 GO:0051879 Hsp90 protein binding 2/784 42/18639 0.0476190476190476 1.13210641399417 0.532385202338344 0.804718329338603 GO:0035091 phosphatidylinositol binding 12/784 284/18639 0.0422535211267606 1.00454512791032 0.535335026715005 0.804718329338603 GO:0140597 protein carrier chaperone 8/784 188/18639 0.0425531914893617 1.0116695614416 0.53747794189367 0.804718329338603 GO:0015081 sodium ion transmembrane transporter activity 7/784 164/18639 0.0426829268292683 1.01475391986063 0.538523192995278 0.804718329338603 GO:0000400 four-way junction DNA binding 1/784 18/18639 0.0555555555555556 1.32079081632653 0.538773983065204 0.804718329338603 GO:0003746 translation elongation factor activity 1/784 18/18639 0.0555555555555556 1.32079081632653 0.538773983065204 0.804718329338603 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 1/784 18/18639 0.0555555555555556 1.32079081632653 0.538773983065204 0.804718329338603 GO:0008525 phosphatidylcholine transporter activity 1/784 18/18639 0.0555555555555556 1.32079081632653 0.538773983065204 0.804718329338603 GO:0015373 monoatomic anion:sodium symporter activity 1/784 18/18639 0.0555555555555556 1.32079081632653 0.538773983065204 0.804718329338603 GO:0022851 GABA-gated chloride ion channel activity 1/784 18/18639 0.0555555555555556 1.32079081632653 0.538773983065204 0.804718329338603 GO:0035615 clathrin adaptor activity 1/784 18/18639 0.0555555555555556 1.32079081632653 0.538773983065204 0.804718329338603 GO:0050811 GABA receptor binding 1/784 18/18639 0.0555555555555556 1.32079081632653 0.538773983065204 0.804718329338603 GO:1901611 phosphatidylglycerol binding 1/784 18/18639 0.0555555555555556 1.32079081632653 0.538773983065204 0.804718329338603 GO:0008200 ion channel inhibitor activity 2/784 43/18639 0.0465116279069767 1.10577835785477 0.54516149610555 0.812960125771434 GO:0005548 phospholipid transporter activity 3/784 68/18639 0.0441176470588235 1.04886329531813 0.549472603230829 0.814212853478073 GO:0001223 transcription coactivator binding 2/784 44/18639 0.0454545454545455 1.08064703153989 0.557691925816838 0.814212853478073 GO:0016248 channel inhibitor activity 2/784 44/18639 0.0454545454545455 1.08064703153989 0.557691925816838 0.814212853478073 GO:0019205 nucleobase-containing compound kinase activity 2/784 44/18639 0.0454545454545455 1.08064703153989 0.557691925816838 0.814212853478073 GO:0030020 extracellular matrix structural constituent conferring tensile strength 2/784 44/18639 0.0454545454545455 1.08064703153989 0.557691925816838 0.814212853478073 GO:0043014 alpha-tubulin binding 2/784 44/18639 0.0454545454545455 1.08064703153989 0.557691925816838 0.814212853478073 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 1/784 19/18639 0.0526315789473684 1.25127551020408 0.558192982972668 0.814212853478073 GO:0004890 GABA-A receptor activity 1/784 19/18639 0.0526315789473684 1.25127551020408 0.558192982972668 0.814212853478073 GO:0008301 DNA binding, bending 1/784 19/18639 0.0526315789473684 1.25127551020408 0.558192982972668 0.814212853478073 GO:0015245 fatty acid transmembrane transporter activity 1/784 19/18639 0.0526315789473684 1.25127551020408 0.558192982972668 0.814212853478073 GO:0022821 solute:potassium antiporter activity 1/784 19/18639 0.0526315789473684 1.25127551020408 0.558192982972668 0.814212853478073 GO:0031420 alkali metal ion binding 1/784 19/18639 0.0526315789473684 1.25127551020408 0.558192982972668 0.814212853478073 GO:0042577 lipid phosphatase activity 1/784 19/18639 0.0526315789473684 1.25127551020408 0.558192982972668 0.814212853478073 GO:0046624 sphingolipid transporter activity 1/784 19/18639 0.0526315789473684 1.25127551020408 0.558192982972668 0.814212853478073 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/784 70/18639 0.0428571428571429 1.01889577259475 0.569261320016713 0.824623369647987 GO:0016782 transferase activity, transferring sulphur-containing groups 3/784 70/18639 0.0428571428571429 1.01889577259475 0.569261320016713 0.824623369647987 GO:0004715 non-membrane spanning protein tyrosine kinase activity 2/784 45/18639 0.0444444444444444 1.05663265306122 0.569974547371365 0.824623369647987 GO:0046915 transition metal ion transmembrane transporter activity 2/784 45/18639 0.0444444444444444 1.05663265306122 0.569974547371365 0.824623369647987 GO:0141110 transporter inhibitor activity 2/784 45/18639 0.0444444444444444 1.05663265306122 0.569974547371365 0.824623369647987 GO:0001614 purinergic nucleotide receptor activity 1/784 20/18639 0.05 1.18871173469388 0.576795383689608 0.824623369647987 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/784 20/18639 0.05 1.18871173469388 0.576795383689608 0.824623369647987 GO:0005326 neurotransmitter transmembrane transporter activity 1/784 20/18639 0.05 1.18871173469388 0.576795383689608 0.824623369647987 GO:0015095 magnesium ion transmembrane transporter activity 1/784 20/18639 0.05 1.18871173469388 0.576795383689608 0.824623369647987 GO:0016408 C-acyltransferase activity 1/784 20/18639 0.05 1.18871173469388 0.576795383689608 0.824623369647987 GO:0016502 nucleotide receptor activity 1/784 20/18639 0.05 1.18871173469388 0.576795383689608 0.824623369647987 GO:0016505 peptidase activator activity involved in apoptotic process 1/784 20/18639 0.05 1.18871173469388 0.576795383689608 0.824623369647987 GO:0042288 MHC class I protein binding 1/784 20/18639 0.05 1.18871173469388 0.576795383689608 0.824623369647987 GO:0015293 symporter activity 6/784 146/18639 0.0410958904109589 0.977023343584009 0.581253640569392 0.82827624558535 GO:0004180 carboxypeptidase activity 2/784 46/18639 0.0434782608695652 1.03366237799468 0.58200801427762 0.82827624558535 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2/784 46/18639 0.0434782608695652 1.03366237799468 0.58200801427762 0.82827624558535 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1/784 21/18639 0.0476190476190476 1.13210641399417 0.594615482469744 0.834261021828355 GO:0001846 opsonin binding 1/784 21/18639 0.0476190476190476 1.13210641399417 0.594615482469744 0.834261021828355 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 1/784 21/18639 0.0476190476190476 1.13210641399417 0.594615482469744 0.834261021828355 GO:0008373 sialyltransferase activity 1/784 21/18639 0.0476190476190476 1.13210641399417 0.594615482469744 0.834261021828355 GO:0015125 bile acid transmembrane transporter activity 1/784 21/18639 0.0476190476190476 1.13210641399417 0.594615482469744 0.834261021828355 GO:0015174 basic amino acid transmembrane transporter activity 1/784 21/18639 0.0476190476190476 1.13210641399417 0.594615482469744 0.834261021828355 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/784 21/18639 0.0476190476190476 1.13210641399417 0.594615482469744 0.834261021828355 GO:0061891 calcium ion sensor activity 1/784 21/18639 0.0476190476190476 1.13210641399417 0.594615482469744 0.834261021828355 GO:0140312 cargo adaptor activity 1/784 21/18639 0.0476190476190476 1.13210641399417 0.594615482469744 0.834261021828355 GO:0004725 protein tyrosine phosphatase activity 4/784 98/18639 0.0408163265306122 0.970376926280716 0.595135937496805 0.834261021828355 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2/784 48/18639 0.0416666666666667 0.990593112244898 0.605324808798415 0.842307126485166 GO:0140693 molecular condensate scaffold activity 2/784 48/18639 0.0416666666666667 0.990593112244898 0.605324808798415 0.842307126485166 GO:0031491 nucleosome binding 3/784 74/18639 0.0405405405405405 0.963820325427468 0.60718648153666 0.842307126485166 GO:0004721 phosphoprotein phosphatase activity 7/784 175/18639 0.04 0.950969387755102 0.607579793819297 0.842307126485166 GO:0043130 ubiquitin binding 4/784 100/18639 0.04 0.950969387755102 0.611139672460826 0.842307126485166 GO:0005243 gap junction channel activity 1/784 22/18639 0.0454545454545455 1.08064703153989 0.611686137843238 0.842307126485166 GO:0015377 chloride:monoatomic cation symporter activity 1/784 22/18639 0.0454545454545455 1.08064703153989 0.611686137843238 0.842307126485166 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 1/784 22/18639 0.0454545454545455 1.08064703153989 0.611686137843238 0.842307126485166 GO:0031683 G-protein beta/gamma-subunit complex binding 1/784 22/18639 0.0454545454545455 1.08064703153989 0.611686137843238 0.842307126485166 GO:0140035 ubiquitin-like protein reader activity 1/784 22/18639 0.0454545454545455 1.08064703153989 0.611686137843238 0.842307126485166 GO:0140517 protein-RNA adaptor activity 1/784 22/18639 0.0454545454545455 1.08064703153989 0.611686137843238 0.842307126485166 GO:0140784 metal ion sensor activity 1/784 22/18639 0.0454545454545455 1.08064703153989 0.611686137843238 0.842307126485166 GO:0001222 transcription corepressor binding 2/784 49/18639 0.0408163265306122 0.970376926280716 0.616608025202446 0.847836034653364 GO:0008238 exopeptidase activity 4/784 102/18639 0.0392156862745098 0.932322929171669 0.626747573364699 0.848578476809232 GO:0015171 amino acid transmembrane transporter activity 4/784 102/18639 0.0392156862745098 0.932322929171669 0.626747573364699 0.848578476809232 GO:0032813 tumor necrosis factor receptor superfamily binding 2/784 50/18639 0.04 0.950969387755102 0.627641784804862 0.848578476809232 GO:0048020 CCR chemokine receptor binding 2/784 50/18639 0.04 0.950969387755102 0.627641784804862 0.848578476809232 GO:0004022 alcohol dehydrogenase (NAD+) activity 1/784 23/18639 0.0434782608695652 1.03366237799468 0.628038829895175 0.848578476809232 GO:0005283 amino acid:sodium symporter activity 1/784 23/18639 0.0434782608695652 1.03366237799468 0.628038829895175 0.848578476809232 GO:0016849 phosphorus-oxygen lyase activity 1/784 23/18639 0.0434782608695652 1.03366237799468 0.628038829895175 0.848578476809232 GO:0016917 GABA receptor activity 1/784 23/18639 0.0434782608695652 1.03366237799468 0.628038829895175 0.848578476809232 GO:0042171 lysophosphatidic acid acyltransferase activity 1/784 23/18639 0.0434782608695652 1.03366237799468 0.628038829895175 0.848578476809232 GO:0043274 phospholipase binding 1/784 23/18639 0.0434782608695652 1.03366237799468 0.628038829895175 0.848578476809232 GO:0071617 lysophospholipid acyltransferase activity 1/784 23/18639 0.0434782608695652 1.03366237799468 0.628038829895175 0.848578476809232 GO:0099186 structural constituent of postsynapse 1/784 23/18639 0.0434782608695652 1.03366237799468 0.628038829895175 0.848578476809232 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 9/784 229/18639 0.0393013100436681 0.934358568755013 0.629745305399498 0.849656364427894 GO:0003724 RNA helicase activity 3/784 77/18639 0.038961038961039 0.926268884177047 0.634132353560583 0.851291338543463 GO:0005253 monoatomic anion channel activity 4/784 103/18639 0.0388349514563107 0.923271250247672 0.634400259827899 0.851291338543463 GO:0035591 signaling adaptor activity 5/784 129/18639 0.0387596899224806 0.921481964878975 0.636501112052498 0.851291338543463 GO:0016597 amino acid binding 2/784 51/18639 0.0392156862745098 0.932322929171669 0.638427083398182 0.851291338543463 GO:0003713 transcription coactivator activity 10/784 256/18639 0.0390625 0.928681042729592 0.639468433339807 0.851291338543463 GO:0004622 lysophospholipase activity 1/784 24/18639 0.0416666666666667 0.990593112244898 0.643703718021635 0.851291338543463 GO:0004806 triacylglycerol lipase activity 1/784 24/18639 0.0416666666666667 0.990593112244898 0.643703718021635 0.851291338543463 GO:0005315 phosphate transmembrane transporter activity 1/784 24/18639 0.0416666666666667 0.990593112244898 0.643703718021635 0.851291338543463 GO:0015295 solute:proton symporter activity 1/784 24/18639 0.0416666666666667 0.990593112244898 0.643703718021635 0.851291338543463 GO:0030552 cAMP binding 1/784 24/18639 0.0416666666666667 0.990593112244898 0.643703718021635 0.851291338543463 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/784 24/18639 0.0416666666666667 0.990593112244898 0.643703718021635 0.851291338543463 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/784 24/18639 0.0416666666666667 0.990593112244898 0.643703718021635 0.851291338543463 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/784 24/18639 0.0416666666666667 0.990593112244898 0.643703718021635 0.851291338543463 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1/784 24/18639 0.0416666666666667 0.990593112244898 0.643703718021635 0.851291338543463 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/784 52/18639 0.0384615384615385 0.914393642072214 0.648965274020504 0.854404881731362 GO:0030159 signaling receptor complex adaptor activity 2/784 52/18639 0.0384615384615385 0.914393642072214 0.648965274020504 0.854404881731362 GO:0008186 ATP-dependent activity, acting on RNA 3/784 79/18639 0.0379746835443038 0.902819039008008 0.651367398548973 0.854404881731362 GO:0016835 carbon-oxygen lyase activity 3/784 79/18639 0.0379746835443038 0.902819039008008 0.651367398548973 0.854404881731362 GO:0015631 tubulin binding 15/784 385/18639 0.038961038961039 0.926268884177047 0.656666611613284 0.854404881731362 GO:0003707 nuclear steroid receptor activity 1/784 25/18639 0.04 0.950969387755102 0.658709696268803 0.854404881731362 GO:0008483 transaminase activity 1/784 25/18639 0.04 0.950969387755102 0.658709696268803 0.854404881731362 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/784 25/18639 0.04 0.950969387755102 0.658709696268803 0.854404881731362 GO:0019706 protein-cysteine S-palmitoyltransferase activity 1/784 25/18639 0.04 0.950969387755102 0.658709696268803 0.854404881731362 GO:0019707 protein-cysteine S-acyltransferase activity 1/784 25/18639 0.04 0.950969387755102 0.658709696268803 0.854404881731362 GO:0042974 nuclear retinoic acid receptor binding 1/784 25/18639 0.04 0.950969387755102 0.658709696268803 0.854404881731362 GO:0047617 fatty acyl-CoA hydrolase activity 1/784 25/18639 0.04 0.950969387755102 0.658709696268803 0.854404881731362 GO:0004864 protein phosphatase inhibitor activity 2/784 53/18639 0.0377358490566038 0.897140931844436 0.659258035216219 0.854404881731362 GO:0000049 tRNA binding 3/784 80/18639 0.0375 0.891533801020408 0.659764668899449 0.854404881731362 GO:0008237 metallopeptidase activity 7/784 184/18639 0.0380434782608696 0.904454580745342 0.65976505305887 0.854404881731362 GO:0030971 receptor tyrosine kinase binding 3/784 81/18639 0.037037037037037 0.880527210884354 0.668014818998205 0.855073311607295 GO:0003925 G protein activity 2/784 54/18639 0.037037037037037 0.880527210884354 0.669307341328979 0.855073311607295 GO:0017069 snRNA binding 2/784 54/18639 0.037037037037037 0.880527210884354 0.669307341328979 0.855073311607295 GO:0050661 NADP binding 2/784 54/18639 0.037037037037037 0.880527210884354 0.669307341328979 0.855073311607295 GO:0030695 GTPase regulator activity 19/784 489/18639 0.0388548057259714 0.923743270314261 0.672206914509262 0.855073311607295 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 1/784 26/18639 0.0384615384615385 0.914393642072214 0.673084446356117 0.855073311607295 GO:0016289 acyl-CoA hydrolase activity 1/784 26/18639 0.0384615384615385 0.914393642072214 0.673084446356117 0.855073311607295 GO:0030247 polysaccharide binding 1/784 26/18639 0.0384615384615385 0.914393642072214 0.673084446356117 0.855073311607295 GO:0030507 spectrin binding 1/784 26/18639 0.0384615384615385 0.914393642072214 0.673084446356117 0.855073311607295 GO:0043548 phosphatidylinositol 3-kinase binding 1/784 26/18639 0.0384615384615385 0.914393642072214 0.673084446356117 0.855073311607295 GO:0050681 nuclear androgen receptor binding 1/784 26/18639 0.0384615384615385 0.914393642072214 0.673084446356117 0.855073311607295 GO:0051139 metal cation:proton antiporter activity 1/784 26/18639 0.0384615384615385 0.914393642072214 0.673084446356117 0.855073311607295 GO:0052742 phosphatidylinositol kinase activity 1/784 26/18639 0.0384615384615385 0.914393642072214 0.673084446356117 0.855073311607295 GO:0070006 metalloaminopeptidase activity 1/784 26/18639 0.0384615384615385 0.914393642072214 0.673084446356117 0.855073311607295 GO:0060589 nucleoside-triphosphatase regulator activity 19/784 490/18639 0.0387755102040816 0.921858079966681 0.675611619369611 0.856696178915874 GO:0008234 cysteine-type peptidase activity 7/784 187/18639 0.0374331550802139 0.88994461420932 0.67619441715499 0.856696178915874 GO:0005254 chloride channel activity 3/784 83/18639 0.036144578313253 0.859309687730514 0.684073886925156 0.86316392462007 GO:0030165 PDZ domain binding 3/784 83/18639 0.036144578313253 0.859309687730514 0.684073886925156 0.86316392462007 GO:0004683 calcium/calmodulin-dependent protein kinase activity 1/784 27/18639 0.037037037037037 0.880527210884354 0.686854488480267 0.86316392462007 GO:0005385 zinc ion transmembrane transporter activity 1/784 27/18639 0.037037037037037 0.880527210884354 0.686854488480267 0.86316392462007 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 1/784 27/18639 0.037037037037037 0.880527210884354 0.686854488480267 0.86316392462007 GO:0035255 ionotropic glutamate receptor binding 1/784 27/18639 0.037037037037037 0.880527210884354 0.686854488480267 0.86316392462007 GO:0019212 phosphatase inhibitor activity 2/784 56/18639 0.0357142857142857 0.849079810495627 0.688684799750344 0.86316392462007 GO:0030170 pyridoxal phosphate binding 2/784 56/18639 0.0357142857142857 0.849079810495627 0.688684799750344 0.86316392462007 GO:1902936 phosphatidylinositol bisphosphate binding 4/784 111/18639 0.036036036036036 0.85672917815775 0.69189192836783 0.865796679951427 GO:0016755 aminoacyltransferase activity 19/784 496/18639 0.0383064516129032 0.910706570934826 0.69563232323833 0.865796679951427 GO:0070279 vitamin B6 binding 2/784 57/18639 0.0350877192982456 0.834183673469388 0.698018138583223 0.865796679951427 GO:0046875 ephrin receptor binding 1/784 28/18639 0.0357142857142857 0.849079810495627 0.700045229992811 0.865796679951427 GO:0046966 nuclear thyroid hormone receptor binding 1/784 28/18639 0.0357142857142857 0.849079810495627 0.700045229992811 0.865796679951427 GO:0050698 proteoglycan sulfotransferase activity 1/784 28/18639 0.0357142857142857 0.849079810495627 0.700045229992811 0.865796679951427 GO:0051019 mitogen-activated protein kinase binding 1/784 28/18639 0.0357142857142857 0.849079810495627 0.700045229992811 0.865796679951427 GO:0051537 2 iron, 2 sulfur cluster binding 1/784 28/18639 0.0357142857142857 0.849079810495627 0.700045229992811 0.865796679951427 GO:0051959 dynein light intermediate chain binding 1/784 28/18639 0.0357142857142857 0.849079810495627 0.700045229992811 0.865796679951427 GO:0097718 disordered domain specific binding 1/784 28/18639 0.0357142857142857 0.849079810495627 0.700045229992811 0.865796679951427 GO:0061980 regulatory RNA binding 2/784 58/18639 0.0344827586206897 0.819801196340605 0.707118348444378 0.873389241473571 GO:0016874 ligase activity 6/784 167/18639 0.0359281437125748 0.854164120738116 0.709068667308845 0.873954631827251 GO:0004181 metallocarboxypeptidase activity 1/784 29/18639 0.0344827586206897 0.819801196340605 0.71268101204029 0.873954631827251 GO:0005416 amino acid:monoatomic cation symporter activity 1/784 29/18639 0.0344827586206897 0.819801196340605 0.71268101204029 0.873954631827251 GO:0035250 UDP-galactosyltransferase activity 1/784 29/18639 0.0344827586206897 0.819801196340605 0.71268101204029 0.873954631827251 GO:0099604 ligand-gated calcium channel activity 1/784 29/18639 0.0344827586206897 0.819801196340605 0.71268101204029 0.873954631827251 GO:0008081 phosphoric diester hydrolase activity 3/784 87/18639 0.0344827586206897 0.819801196340605 0.714436215674279 0.873954631827251 GO:0001786 phosphatidylserine binding 2/784 59/18639 0.0338983050847458 0.805906260809409 0.71598850051302 0.873954631827251 GO:0004879 nuclear receptor activity 2/784 59/18639 0.0338983050847458 0.805906260809409 0.71598850051302 0.873954631827251 GO:0070888 E-box binding 2/784 59/18639 0.0338983050847458 0.805906260809409 0.71598850051302 0.873954631827251 GO:0019787 ubiquitin-like protein transferase activity 18/784 479/18639 0.0375782881002088 0.893395040688509 0.722164272760237 0.876680619955556 GO:0098531 ligand-modulated transcription factor activity 2/784 60/18639 0.0333333333333333 0.792474489795918 0.724631820197279 0.876680619955556 GO:0016769 transferase activity, transferring nitrogenous groups 1/784 30/18639 0.0333333333333333 0.792474489795918 0.724785154252026 0.876680619955556 GO:0031624 ubiquitin conjugating enzyme binding 1/784 30/18639 0.0333333333333333 0.792474489795918 0.724785154252026 0.876680619955556 GO:0033612 receptor serine/threonine kinase binding 1/784 30/18639 0.0333333333333333 0.792474489795918 0.724785154252026 0.876680619955556 GO:0035925 mRNA 3'-UTR AU-rich region binding 1/784 30/18639 0.0333333333333333 0.792474489795918 0.724785154252026 0.876680619955556 GO:0098918 structural constituent of synapse 1/784 30/18639 0.0333333333333333 0.792474489795918 0.724785154252026 0.876680619955556 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 3/784 89/18639 0.0337078651685393 0.801378697546434 0.728749388478898 0.879200875132606 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 3/784 89/18639 0.0337078651685393 0.801378697546434 0.728749388478898 0.879200875132606 GO:0141003 histone H2AX kinase activity 13/784 354/18639 0.0367231638418079 0.873065115876859 0.730794147151701 0.880531607715 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 2/784 61/18639 0.0327868852459016 0.779483104717297 0.733051668764455 0.880981118630804 GO:0016836 hydro-lyase activity 2/784 61/18639 0.0327868852459016 0.779483104717297 0.733051668764455 0.880981118630804 GO:0140793 histone H2AXY142 phosphatase activity 3/784 90/18639 0.0333333333333333 0.792474489795918 0.735692052434457 0.881581687216394 GO:0017147 Wnt-protein binding 1/784 31/18639 0.032258064516129 0.766910796576695 0.736379997557224 0.881581687216394 GO:0072349 modified amino acid transmembrane transporter activity 1/784 31/18639 0.032258064516129 0.766910796576695 0.736379997557224 0.881581687216394 GO:0140996 histone H3 kinase activity 13/784 357/18639 0.0364145658263305 0.865728434230835 0.741501687439535 0.88657810454727 GO:0008378 galactosyltransferase activity 1/784 32/18639 0.03125 0.742944834183674 0.747486945209585 0.888056281792836 GO:0030515 snoRNA binding 1/784 32/18639 0.03125 0.742944834183674 0.747486945209585 0.888056281792836 GO:0031369 translation initiation factor binding 1/784 32/18639 0.03125 0.742944834183674 0.747486945209585 0.888056281792836 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1/784 32/18639 0.03125 0.742944834183674 0.747486945209585 0.888056281792836 GO:0051059 NF-kappaB binding 1/784 32/18639 0.03125 0.742944834183674 0.747486945209585 0.888056281792836 GO:0032182 ubiquitin-like protein binding 4/784 120/18639 0.0333333333333333 0.792474489795918 0.748526250359471 0.888162492495058 GO:0035173 histone kinase activity 13/784 360/18639 0.0361111111111111 0.858514030612245 0.751927263572152 0.891067162788291 GO:0019956 chemokine binding 1/784 33/18639 0.0303030303030303 0.720431354359926 0.758126502094396 0.897182300556407 GO:0008528 G protein-coupled peptide receptor activity 4/784 122/18639 0.0327868852459016 0.779483104717297 0.759966184000721 0.897182300556407 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 4/784 122/18639 0.0327868852459016 0.779483104717297 0.759966184000721 0.897182300556407 GO:0019825 oxygen binding 1/784 34/18639 0.0294117647058824 0.699242196878752 0.768318312389892 0.904757710433941 GO:0030332 cyclin binding 1/784 34/18639 0.0294117647058824 0.699242196878752 0.768318312389892 0.904757710433941 GO:0008235 metalloexopeptidase activity 2/784 66/18639 0.0303030303030303 0.720431354359926 0.771923942543182 0.907860234311793 GO:0016229 steroid dehydrogenase activity 1/784 35/18639 0.0285714285714286 0.679263848396501 0.778081195651721 0.912805417734453 GO:0043015 gamma-tubulin binding 1/784 35/18639 0.0285714285714286 0.679263848396501 0.778081195651721 0.912805417734453 GO:0030594 neurotransmitter receptor activity 3/784 97/18639 0.0309278350515464 0.735285609088996 0.780409867739915 0.914390007940878 GO:0004842 ubiquitin-protein transferase activity 16/784 449/18639 0.0356347438752784 0.847188764147084 0.786409884651228 0.914698727868695 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/784 36/18639 0.0277777777777778 0.660395408163265 0.787433181386458 0.914698727868695 GO:0044390 ubiquitin-like protein conjugating enzyme binding 1/784 36/18639 0.0277777777777778 0.660395408163265 0.787433181386458 0.914698727868695 GO:0001653 peptide receptor activity 4/784 128/18639 0.03125 0.742944834183674 0.791864548706953 0.914698727868695 GO:1901981 phosphatidylinositol phosphate binding 6/784 185/18639 0.0324324324324324 0.771056260341975 0.795200787464749 0.914698727868695 GO:0022829 wide pore channel activity 1/784 37/18639 0.027027027027027 0.642546883618312 0.796391542177353 0.914698727868695 GO:0023023 MHC protein complex binding 1/784 37/18639 0.027027027027027 0.642546883618312 0.796391542177353 0.914698727868695 GO:0030280 structural constituent of skin epidermis 1/784 37/18639 0.027027027027027 0.642546883618312 0.796391542177353 0.914698727868695 GO:0030551 cyclic nucleotide binding 1/784 37/18639 0.027027027027027 0.642546883618312 0.796391542177353 0.914698727868695 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 9/784 268/18639 0.0335820895522388 0.798388478525739 0.799038181069304 0.914698727868695 GO:0140299 molecular sensor activity 2/784 71/18639 0.028169014084507 0.669696751940213 0.805764984538604 0.914698727868695 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 8/784 243/18639 0.0329218106995885 0.782690854119426 0.806615251255262 0.914698727868695 GO:0042379 chemokine receptor binding 2/784 72/18639 0.0277777777777778 0.660395408163265 0.811972426722299 0.914698727868695 GO:0000217 DNA secondary structure binding 1/784 39/18639 0.0256410256410256 0.609595761381476 0.813192883745988 0.914698727868695 GO:0004676 3-phosphoinositide-dependent protein kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0004711 ribosomal protein S6 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0035175 histone H3S10 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0035979 histone H2AXS139 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0044022 histone H3S28 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0044023 histone H4S1 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0044024 histone H2AS1 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0044025 histone H2BS14 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0072354 histone H3T3 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0072371 histone H2AS121 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0072518 Rho-dependent protein serine/threonine kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0140823 histone H2BS36 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0140855 histone H3S57 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0140995 histone H2A kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0140997 histone H4 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0140998 histone H2B kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:1990244 histone H2AT120 kinase activity 8/784 245/18639 0.0326530612244898 0.776301541024573 0.813604617132308 0.914698727868695 GO:0016791 phosphatase activity 9/784 273/18639 0.032967032967033 0.78376597891904 0.815832880506887 0.914698727868695 GO:0004677 DNA-dependent protein kinase activity 8/784 246/18639 0.032520325203252 0.773145843703335 0.817026208747483 0.914698727868695 GO:0140857 histone H3T45 kinase activity 8/784 246/18639 0.032520325203252 0.773145843703335 0.817026208747483 0.914698727868695 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/784 73/18639 0.0273972602739726 0.651348895722673 0.818002171957913 0.914698727868695 GO:0035402 histone H3T11 kinase activity 8/784 247/18639 0.0323886639676113 0.770015698587127 0.820399429493232 0.914698727868695 GO:0035403 histone H3T6 kinase activity 8/784 247/18639 0.0323886639676113 0.770015698587127 0.820399429493232 0.914698727868695 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 1/784 40/18639 0.025 0.594355867346939 0.821066904130028 0.914698727868695 GO:0061791 GTPase motor activity 1/784 40/18639 0.025 0.594355867346939 0.821066904130028 0.914698727868695 GO:1990606 membrane scission GTPase motor activity 1/784 40/18639 0.025 0.594355867346939 0.821066904130028 0.914698727868695 GO:0004679 AMP-activated protein kinase activity 8/784 248/18639 0.032258064516129 0.766910796576695 0.82372456093496 0.914698727868695 GO:0008017 microtubule binding 9/784 276/18639 0.0326086956521739 0.775246783496007 0.825386755419868 0.914698727868695 GO:0140104 molecular carrier activity 8/784 249/18639 0.0321285140562249 0.763830833538234 0.827001895353185 0.914698727868695 GO:0001727 lipid kinase activity 1/784 41/18639 0.024390243902439 0.579859382777501 0.828609435833994 0.914698727868695 GO:0004812 aminoacyl-tRNA ligase activity 1/784 41/18639 0.024390243902439 0.579859382777501 0.828609435833994 0.914698727868695 GO:0008227 G protein-coupled amine receptor activity 1/784 41/18639 0.024390243902439 0.579859382777501 0.828609435833994 0.914698727868695 GO:0016875 ligase activity, forming carbon-oxygen bonds 1/784 41/18639 0.024390243902439 0.579859382777501 0.828609435833994 0.914698727868695 GO:0042287 MHC protein binding 1/784 41/18639 0.024390243902439 0.579859382777501 0.828609435833994 0.914698727868695 GO:0140828 metal cation:monoatomic cation antiporter activity 1/784 41/18639 0.024390243902439 0.579859382777501 0.828609435833994 0.914698727868695 GO:0001217 DNA-binding transcription repressor activity 9/784 278/18639 0.0323741007194245 0.769669468506827 0.831541787732968 0.916853268314063 GO:0017022 myosin binding 2/784 76/18639 0.0263157894736842 0.625637755102041 0.835064567077245 0.918337461838714 GO:0004520 DNA endonuclease activity 1/784 42/18639 0.0238095238095238 0.566053206997085 0.835834417138766 0.918337461838714 GO:0043175 RNA polymerase core enzyme binding 1/784 42/18639 0.0238095238095238 0.566053206997085 0.835834417138766 0.918337461838714 GO:0004843 cysteine-type deubiquitinase activity 3/784 108/18639 0.0277777777777778 0.660395408163265 0.837924108510471 0.9195528655602 GO:0042578 phosphoric ester hydrolase activity 12/784 363/18639 0.0330578512396694 0.785925113847192 0.840605566781815 0.921243196100697 GO:0140767 enzyme-substrate adaptor activity 4/784 139/18639 0.0287769784172662 0.684150638672735 0.841434961999995 0.921243196100697 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1/784 43/18639 0.0232558139534884 0.552889178927385 0.84275520097289 0.921609488783219 GO:0000287 magnesium ion binding 7/784 230/18639 0.0304347826086957 0.723563664596273 0.855173834884965 0.933619655754563 GO:0008009 chemokine activity 1/784 45/18639 0.0222222222222222 0.528316326530612 0.855734807467017 0.933619655754563 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 1/784 46/18639 0.0217391304347826 0.516831188997338 0.861817625093448 0.939160232473629 GO:0003735 structural constituent of ribosome 5/784 175/18639 0.0285714285714286 0.679263848396501 0.864240736679383 0.940704410704567 GO:0101005 deubiquitinase activity 3/784 115/18639 0.0260869565217391 0.620197426796806 0.867342769836531 0.941122275126208 GO:0001784 phosphotyrosine residue binding 1/784 47/18639 0.0212765957446809 0.505834780720799 0.867644279314216 0.941122275126208 GO:0099095 ligand-gated monoatomic anion channel activity 1/784 47/18639 0.0212765957446809 0.505834780720799 0.867644279314216 0.941122275126208 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 16/784 484/18639 0.0330578512396694 0.785925113847192 0.869826462776857 0.94171382265566 GO:0015085 calcium ion transmembrane transporter activity 4/784 147/18639 0.0272108843537415 0.646917950853811 0.870920336101199 0.94171382265566 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1/784 48/18639 0.0208333333333333 0.495296556122449 0.873225544644339 0.94171382265566 GO:0032266 phosphatidylinositol-3-phosphate binding 1/784 48/18639 0.0208333333333333 0.495296556122449 0.873225544644339 0.94171382265566 GO:0038187 pattern recognition receptor activity 1/784 48/18639 0.0208333333333333 0.495296556122449 0.873225544644339 0.94171382265566 GO:0035254 glutamate receptor binding 1/784 49/18639 0.0204081632653061 0.485188463140358 0.878571742966045 0.945490952753102 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 2/784 86/18639 0.0232558139534884 0.552889178927385 0.881975111792216 0.945490952753102 GO:0001216 DNA-binding transcription activator activity 16/784 491/18639 0.0325865580448065 0.774720478822894 0.882977370431065 0.945490952753102 GO:0000510 H3-H4 histone complex chaperone activity 4/784 151/18639 0.0264900662251656 0.629781051493445 0.883806516263328 0.945490952753102 GO:0140584 chromatin extrusion motor activity 4/784 151/18639 0.0264900662251656 0.629781051493445 0.883806516263328 0.945490952753102 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 4/784 151/18639 0.0264900662251656 0.629781051493445 0.883806516263328 0.945490952753102 GO:0140849 ATP-dependent H2AZ histone chaperone activity 4/784 151/18639 0.0264900662251656 0.629781051493445 0.883806516263328 0.945490952753102 GO:0015616 DNA translocase activity 4/784 152/18639 0.0263157894736842 0.625637755102041 0.886847828162593 0.946286106100361 GO:0140674 ATP-dependent histone chaperone activity 4/784 152/18639 0.0263157894736842 0.625637755102041 0.886847828162593 0.946286106100361 GO:0005096 GTPase activator activity 8/784 271/18639 0.029520295202952 0.701822426387529 0.887710596635597 0.946286106100361 GO:0005048 signal sequence binding 1/784 51/18639 0.0196078431372549 0.466161464585834 0.888598076102799 0.946286106100361 GO:0061775 cohesin loader activity 4/784 153/18639 0.0261437908496732 0.621548619447779 0.889819472481364 0.946508767656513 GO:0005246 calcium channel regulator activity 1/784 53/18639 0.0188679245283019 0.448570465922218 0.897797503175037 0.952827089067718 GO:0140296 general transcription initiation factor binding 1/784 53/18639 0.0188679245283019 0.448570465922218 0.897797503175037 0.952827089067718 GO:0140658 ATP-dependent chromatin remodeler activity 4/784 158/18639 0.0253164556962025 0.601879359338672 0.903674738528976 0.957977188803393 GO:0046873 metal ion transmembrane transporter activity 14/784 450/18639 0.0311111111111111 0.739642857142857 0.906453359408492 0.958364913121606 GO:0019783 ubiquitin-like protein peptidase activity 3/784 127/18639 0.0236220472440945 0.561596095130966 0.90693867546394 0.958364913121606 GO:0051219 phosphoprotein binding 2/784 93/18639 0.021505376344086 0.511273864384464 0.907115452526868 0.958364913121606 GO:0003689 DNA clamp loader activity 4/784 160/18639 0.025 0.594355867346939 0.908770971646894 0.958447400112732 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 1/784 56/18639 0.0178571428571429 0.424539905247813 0.91019365738941 0.958447400112732 GO:0016410 N-acyltransferase activity 2/784 94/18639 0.0212765957446809 0.505834780720799 0.910268760748776 0.958447400112732 GO:0008276 protein methyltransferase activity 2/784 95/18639 0.0210526315789474 0.500510204081633 0.913321577994187 0.960580062344842 GO:0140713 histone chaperone activity 4/784 164/18639 0.024390243902439 0.579859382777501 0.918250302176885 0.964409010222729 GO:0031593 polyubiquitin modification-dependent protein binding 1/784 59/18639 0.0169491525423729 0.402953130404704 0.921087963774222 0.964409010222729 GO:0045309 protein phosphorylated amino acid binding 1/784 59/18639 0.0169491525423729 0.402953130404704 0.921087963774222 0.964409010222729 GO:0070063 RNA polymerase binding 1/784 59/18639 0.0169491525423729 0.402953130404704 0.921087963774222 0.964409010222729 GO:0016779 nucleotidyltransferase activity 3/784 136/18639 0.0220588235294118 0.524431647659064 0.929249944795397 0.971866553001897 GO:0022824 transmitter-gated monoatomic ion channel activity 1/784 63/18639 0.0158730158730159 0.377368804664723 0.933588418830563 0.974224521882339 GO:0022835 transmitter-gated channel activity 1/784 63/18639 0.0158730158730159 0.377368804664723 0.933588418830563 0.974224521882339 GO:0004536 DNA nuclease activity 1/784 64/18639 0.015625 0.371472417091837 0.936391319327808 0.976060070871238 GO:0016887 ATP hydrolysis activity 12/784 417/18639 0.0287769784172662 0.684150638672735 0.938887656426362 0.977572337147715 GO:0002039 p53 binding 1/784 69/18639 0.0144927536231884 0.344554125998225 0.948729946670093 0.985625000151708 GO:0098960 postsynaptic neurotransmitter receptor activity 1/784 69/18639 0.0144927536231884 0.344554125998225 0.948729946670093 0.985625000151708 GO:0061659 ubiquitin-like protein ligase activity 10/784 372/18639 0.0268817204301075 0.639092330480579 0.953629502327918 0.989615521283688 GO:0004674 protein serine/threonine kinase activity 12/784 433/18639 0.0277136258660508 0.658870245557807 0.955359963621375 0.9903121574124 GO:0004521 RNA endonuclease activity 1/784 73/18639 0.0136986301369863 0.325674447861336 0.956855730506266 0.990764239228526 GO:0003774 cytoskeletal motor activity 3/784 153/18639 0.0196078431372549 0.466161464585834 0.958536825867166 0.99140700463031 GO:0004386 helicase activity 3/784 155/18639 0.0193548387096774 0.460146477946017 0.961113191052613 0.992434543724931 GO:0051536 iron-sulfur cluster binding 1/784 76/18639 0.0131578947368421 0.31281887755102 0.962094100649313 0.992434543724931 GO:0051540 metal cluster binding 1/784 77/18639 0.012987012987013 0.308756294725683 0.963695039349466 0.992434543724931 GO:0061630 ubiquitin protein ligase activity 9/784 353/18639 0.0254957507082153 0.606141961033705 0.96377600609865 0.992434543724931 GO:0003697 single-stranded DNA binding 2/784 121/18639 0.0165289256198347 0.392962556923596 0.965561078025329 0.993178886637714 GO:0015079 potassium ion transmembrane transporter activity 3/784 160/18639 0.01875 0.445766900510204 0.966911337607133 0.993474835893043 GO:0106310 protein serine kinase activity 9/784 361/18639 0.0249307479224377 0.592709452201933 0.969843913517314 0.994954019054163 GO:0004519 endonuclease activity 2/784 127/18639 0.015748031496063 0.374397396753977 0.972317260666764 0.994954019054163 GO:0042826 histone deacetylase binding 2/784 127/18639 0.015748031496063 0.374397396753977 0.972317260666764 0.994954019054163 GO:0004527 exonuclease activity 1/784 84/18639 0.0119047619047619 0.283026603498542 0.973161933031534 0.994954019054163 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 3/784 167/18639 0.0179640718562874 0.427082060369058 0.973671580143914 0.994954019054163 GO:0005262 calcium channel activity 2/784 131/18639 0.0152671755725191 0.362965415173703 0.976090493352703 0.996336911882945 GO:0008094 ATP-dependent activity, acting on DNA 4/784 210/18639 0.019047619047619 0.452842565597668 0.978675833301957 0.997886482156303 GO:0016741 transferase activity, transferring one-carbon groups 4/784 215/18639 0.0186046511627907 0.442311343141908 0.981717020454389 0.999896965277619 GO:0016407 acetyltransferase activity 1/784 96/18639 0.0104166666666667 0.247648278061224 0.98401568789596 0.999984319577623 GO:0008170 N-methyltransferase activity 1/784 98/18639 0.0102040816326531 0.242594231570179 0.985338785939912 0.999984319577623 GO:0008168 methyltransferase activity 3/784 204/18639 0.0147058823529412 0.349621098439376 0.992453308500254 0.999984319577623 GO:0042393 histone binding 4/784 247/18639 0.0161943319838057 0.385007849293564 0.993367305909338 0.999984319577623 GO:0004518 nuclease activity 3/784 209/18639 0.0143540669856459 0.341256957328386 0.993655322092674 0.999984319577623 GO:0004540 RNA nuclease activity 1/784 121/18639 0.00826446280991736 0.196481278461798 0.994575668689591 0.999984319577623 GO:0140030 modification-dependent protein binding 2/784 173/18639 0.0115606936416185 0.274846643859856 0.995056279002712 0.999984319577623 GO:0015276 ligand-gated monoatomic ion channel activity 2/784 186/18639 0.010752688172043 0.255636932192232 0.9969989698232 0.999984319577623 GO:0099094 ligand-gated monoatomic cation channel activity 1/784 136/18639 0.00735294117647059 0.174810549219688 0.997165825083864 0.999984319577623 GO:0022834 ligand-gated channel activity 2/784 188/18639 0.0106382978723404 0.2529173903604 0.997221896148692 0.999984319577623 GO:0140101 catalytic activity, acting on a tRNA 1/784 139/18639 0.00719424460431655 0.171037659668184 0.997511058368305 0.999984319577623 GO:0140097 catalytic activity, acting on DNA 5/784 336/18639 0.0148809523809524 0.353783254373178 0.998704711297234 0.999984319577623 GO:0005216 monoatomic ion channel activity 8/784 448/18639 0.0178571428571429 0.424539905247813 0.998716360569929 0.999984319577623 GO:0005261 monoatomic cation channel activity 4/784 341/18639 0.0117302052785924 0.278876653300616 0.999729787964949 0.999984319577623 GO:0140098 catalytic activity, acting on RNA 5/784 387/18639 0.0129198966408269 0.307160654959658 0.999762689800539 0.999984319577623 GO:0003730 mRNA 3'-UTR binding 2/784 262/18639 0.00763358778625954 0.181482707586852 0.999849344887496 0.999984319577623 GO:0022836 gated channel activity 2/784 318/18639 0.00628930817610063 0.149523488640739 0.999984319577623 0.999984319577623