category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	24/257	95/9376	9.21662912144174	CCL3/CXCL3/CCL3L1/FOS/JUN/CXCL2/HLA-DQA2/IL1B/HLA-DRA/TNF/HLA-DPB1/CXCL1/HLA-DMA/HLA-DRB1/HLA-DPA1/IL6/HLA-DMB/HLA-DQA1/ATP6V0E1/CCL3L3/ATP6V1F/ATP6V0B/CCL20/CD86	13.5125306713682
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	20/257	82/9376	8.8981683591155	CD74/HLA-DQA2/HLA-DRA/B2M/TNF/IFI30/LGMN/HLA-DPB1/HLA-DMA/HSP90AB1/HLA-DRB1/HSPA8/HSPA5/HLA-DPA1/CTSS/HSPA1A/HLA-DMB/HLA-DQA1/HSPA1B/PDIA3	12.0589798964895
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	33/257	275/9376	4.37789883268482	C1QC/C1QB/EGR1/IL1B/TNF/C1QA/UQCR10/NDUFA4/HSPA8/COX6C/CYBA/CYCS/COX7B/HSPA5/TUBA1A/HSPA1A/COX7A2/IL6/PSMB3/TUBA1B/NDUFA12/COX6A1/NDUFB2/NDUFC2/SLC25A5/HSPA1B/NDUFB1/NDUFA1/COX6B1/UQCRQ/NDUFA6/NDUFB3/NDUFB9	9.54436457541929
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/257	78/9376	8.41903621670159	NFKBIA/FOS/JUN/HLA-DQA2/IL1B/HLA-DRA/TNF/HLA-DPB1/FCGR2A/HLA-DMA/HLA-DRB1/CYBA/HLA-DPA1/FCGR3B/IL10/HLA-DMB/HLA-DQA1/PTGS2	11.045327909468
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	24/257	155/9376	5.64890171959332	HLA-DQA2/HLA-DRA/CD14/HLA-DPB1/FCGR2A/HLA-DMA/HLA-DRB1/CYBA/OLR1/HLA-DPA1/TUBA1A/CTSS/FCGR3B/HLA-DMB/HLA-DQA1/ATP6V0E1/ATP6V1F/MSR1/SEC61G/ATP6V0B/TUBA1B/SEC61B/THBS1/ACTB	9.79728620487247
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	24/257	157/9376	5.57694118813353	FOS/JUN/IL1B/TNF/UQCR10/NDUFA4/COX6C/CYCS/COX7B/COX7A2/CDC42/IL6/SOCS3/NDUFA12/COX6A1/NDUFB2/NDUFC2/NDUFB1/NDUFA1/COX6B1/UQCRQ/NDUFA6/NDUFB3/NDUFB9	9.70871701532189
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	27/257	216/9376	4.56031128404669	CCL3/CXCL3/CCL3L1/NFKBIA/FOS/JUN/CXCL2/IL1B/CD14/CALM2/TNF/CXCL1/HSP90AB1/HSPA8/CYBA/OLR1/CYCS/HSPA5/HSPA1A/CDC42/IL6/CCL3L3/HSPD1/NFE2L2/CALM1/HSPA1B/LY96	8.8868060391829
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	30/257	268/9376	4.0838608513851	CALM2/UBB/UQCR10/NDUFA4/COX6C/CYCS/COX7B/HSPA5/UBC/TUBA1A/COX7A2/TXN/PSMB3/TUBA1B/NFE2L2/PARK7/NDUFA12/COX6A1/NDUFB2/NDUFC2/SLC25A5/CALM1/NDUFB1/SLC39A6/NDUFA1/COX6B1/UQCRQ/NDUFA6/NDUFB3/NDUFB9	8.59862980634174
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/257	44/9376	10.778917580474	HLA-DQA2/IL1B/HLA-DRA/TNF/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/HLA-DMB/HLA-DQA1/HSPD1/CD86/GZMB	10.9146132378124
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/257	45/9376	10.5393860786857	HLA-DQA2/IL1B/HLA-DRA/TNF/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/IL6/HLA-DMB/HLA-DQA1/CD86/GZMB	10.768152070176
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	21/257	138/9376	5.55168330231771	UQCR10/NDUFA4/COX6C/CYCS/COX7B/COX7A2/ATP6V0E1/ATP6V1F/ATP6V0B/PPA1/NDUFA12/COX6A1/NDUFB2/NDUFC2/NDUFB1/NDUFA1/COX6B1/UQCRQ/NDUFA6/NDUFB3/NDUFB9	9.0427639294553
Human Diseases	Immune disease	hsa05330	Allograft rejection	12/257	39/9376	11.2253816222688	HLA-DQA2/HLA-DRA/TNF/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/IL10/HLA-DMB/HLA-DQA1/CD86/GZMB	10.7420394118618
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/257	105/9376	6.25414118954975	CXCL3/CCL4/NFKBIA/CXCL2/GADD45B/IL1B/CCL4L2/CD14/TNF/BCL2A1/CXCL1/CCL4L1/TNFAIP3/PTGS2/CCL13/BIRC3/GADD45G/LY96	9.08890763545259
Human Diseases	Immune disease	hsa05310	Asthma	11/257	32/9376	12.5408560311284	HLA-DQA2/HLA-DRA/TNF/FCER1G/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/IL10/HLA-DMB/HLA-DQA1	10.9780496255124
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	23/257	181/9376	4.63589655394802	CD74/HLA-DQA2/IL1B/HLA-DRA/CD14/CALM2/TNF/FCER1G/HLA-DPB1/FCGR2A/HLA-DMA/HLA-DRB1/CYCS/HLA-DPA1/CTSS/FCGR3B/IL10/IL6/HLA-DMB/HLA-DQA1/ATP6V0B/HSPD1/CALM1	8.29188998115889
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	17/257	99/9376	6.26467004677121	C1QC/C1QB/HLA-DQA2/HLA-DRA/C1QA/C5AR1/HLA-DPB1/FCGR2A/HLA-DMA/HLA-DRB1/HLA-DPA1/FCGR3B/IL10/HLA-DMB/HLA-DQA1/CFD/KRT10	8.84023008993161
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/257	100/9376	6.2020233463035	CCL3/CXCL3/CCL4/CCL3L1/CXCL2/CCL4L2/TNF/CXCL1/CCL4L1/IL10/IL6/CCL3L3/CXCL14/CCL20/CXCR4/CCL13/CXCR2	8.77951487470835
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	13/257	56/9376	8.46914952751529	CXCL3/NFKBIA/CXCL2/IL1B/CD14/TNF/CXCL1/HSPA8/CYCS/HSPA1A/IL6/HSPD1/HSPA1B	9.41100064442827
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	25/257	227/9376	4.01789540444643	NFKBIA/FOS/JUN/UQCR10/NDUFA4/COX6C/CYBA/MGST3/COX7B/COX7A2/GRB2/NFE2L2/NDUFA12/COX6A1/NDUFB2/NDUFC2/SLC25A5/NDUFB1/HMOX1/NDUFA1/COX6B1/UQCRQ/NDUFA6/NDUFB3/NDUFB9	7.72696402976728
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	16/257	94/9376	6.20978557827635	CXCL3/NFKBIA/FOS/JUN/CXCL2/S100A8/IL1B/TNF/FOSB/CXCL1/S100A9/HSP90AB1/TNFAIP3/IL6/PTGS2/CCL20	8.52200110082151
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/257	50/9376	8.75579766536965	HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/IL10/IL6/HLA-DMB/HLA-DQA1/CD86/CXCR4	9.23086414343104
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	17/257	112/9376	5.53752084491384	NFKBIA/HLA-DQA2/HLA-DRA/TNF/HLA-DPB1/HLA-DMA/HLA-DRB1/HSPA8/CYCS/HLA-DPA1/HSPA1A/IL10/HLA-DMB/HLA-DQA1/BIRC3/HSPA1B/LY96	8.10974060591795
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/257	78/9376	6.54813927965679	C1QC/FOS/JUN/C1QB/IL1B/CD14/CALM2/TNF/C1QA/IL10/IL6/CALM1/LY96/IRF1	8.25997014184326
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	13/257	66/9376	7.18594505364933	JUN/HLA-DQA2/IL1B/HLA-DRA/TNF/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/IL10/IL6/HLA-DMB/HLA-DQA1	8.46606848624514
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	17/257	119/9376	5.21178432462479	CXCL3/NFKBIA/FOS/JUN/CXCL2/JUNB/IL1B/TNF/CXCL1/TNFAIP3/IL6/PTGS2/CCL20/SOCS3/BIRC3/MAP3K8/IRF1	7.7621684756997
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/257	109/9376	5.35522792988969	CCL3/CCL4/CCL3L1/NFKBIA/FOS/JUN/IL1B/CCL4L2/CD14/TNF/CCL4L1/IL6/CCL3L3/CD86/MAP3K8/LY96	7.67773552889898
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	24/257	248/9376	3.53056357474583	NFKBIA/FOS/JUN/IL1B/CD14/TNF/PFN1/ARPC2/HSP90AB1/DYNLL1/CYCS/ARPC5/TUBA1A/CDC42/IL6/TXN/TUBA1B/BIRC3/ARPC3/PAK1/SKP1/ARL8B/LY96/ACTB	6.78006518329205
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	31/257	388/9376	2.9148381403185	IL1B/CALM2/TNF/UQCR10/NDUFA4/COX6C/CYCS/COX7B/TUBA1A/COX7A2/NRBF2/IL6/APOE/PTGS2/PSMB3/TUBA1B/NDUFA12/COX6A1/NDUFB2/NDUFC2/SLC25A5/CALM1/NDUFB1/MME/SLC39A6/NDUFA1/COX6B1/UQCRQ/NDUFA6/NDUFB3/NDUFB9	6.46688282955094
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/257	54/9376	7.43161838881683	HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/IL10/HLA-DMB/HLA-DQA1/CD86/GZMB	7.95685036477165
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	22/257	224/9376	3.58310172317954	NFKBIA/FOS/JUN/HLA-DQA2/EGR1/HLA-DRA/ZFP36/B2M/TNF/HLA-DPB1/HLA-DMA/CDKN1A/HLA-DRB1/HLA-DPA1/IL6/HLA-DMB/HLA-DQA1/EGR2/SPI1/TLN1/SLC25A5/IL1R2	6.56880099017978
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	19/257	174/9376	3.98372020215573	PPP1R15A/DNAJB1/DNAJA1/HSP90AB1/HSPA8/HSPA5/HSPA1A/OSTC/CRYAB/SEC61G/HERPUD1/TMEM258/NFE2L2/SEC61B/PDIA6/HSPA1B/SKP1/HSPH1/PDIA3	6.669145561924
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	34/257	480/9376	2.58417639429313	IL1B/CALM2/TNF/UBB/UQCR10/NDUFA4/COX6C/CYCS/COX7B/HSPA5/UBC/TUBA1A/COX7A2/NRBF2/IL6/PTGS2/PSMB3/GPX1/MAP1LC3B/TUBA1B/PARK7/NDUFA12/COX6A1/NDUFB2/NDUFC2/SLC25A5/CALM1/NDUFB1/NDUFA1/COX6B1/UQCRQ/NDUFA6/NDUFB3/NDUFB9	5.98143463573791
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/257	71/9376	6.16605469392229	CXCL3/NFKBIA/JUN/CXCL2/CXCL1/CDC42/ATP6V0E1/HBEGF/ATP6V1F/ATP6V0B/PAK1/CXCR2	7.33514287392808
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/257	180/9376	3.85092952875054	NFKBIA/CD74/HLA-DQA2/IL1B/HLA-DRA/B2M/TNF/HLA-DPB1/HLA-DMA/HLA-DRB1/CYCS/PILRA/HLA-DPA1/IL6/HLA-DMB/HLA-DQA1/SOCS3/BIRC3/PDIA3	6.48338550201657
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	14/257	100/9376	5.1075486381323	HLA-DQA2/IL1B/HLA-DRA/CD14/TNF/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/IL6/HLA-DMB/HLA-DQA1/MME/IL1R2	6.93235727069467
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	20/257	205/9376	3.5592673436462	NFKBIA/JUN/GADD45B/HLA-DQA2/HLA-DRA/B2M/TNF/HLA-DPB1/HLA-DMA/CDKN1A/HLA-DRB1/CYCS/HLA-DPA1/TNFAIP3/IL6/HLA-DMB/HLA-DQA1/HES1/GADD45G/PDIA3	6.21960538512029
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	16/257	137/9376	4.26072879093414	NFKBIA/FOS/JUN/GADD45B/TNF/BCL2A1/CYCS/TUBA1A/CTSS/CTSC/TUBA1B/GZMB/PMAIP1/BIRC3/GADD45G/ACTB	6.45417995451205
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	14/257	109/9376	4.68582443865348	NFKBIA/FOS/JUN/HLA-DQA2/IL1B/HLA-DRA/HLA-DPB1/HLA-DMA/HSP90AB1/HLA-DRB1/HLA-DPA1/IL6/HLA-DMB/HLA-DQA1	6.49765883703145
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	19/257	196/9376	3.53656793456682	CXCL3/NFKBIA/FOS/JUN/CXCL2/ZFP36/CALM2/UBB/CXCL1/CDKN1A/CYCS/UBC/IL6/PTGS2/MAP1LC3B/CD86/CALM1/ATG3/CLEC2B	6.02464949253689
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	16/257	143/9376	4.08195695355228	C1QC/C1QB/HLA-DQA2/HLA-DRA/TNF/C1QA/HLA-DPB1/FCGR2A/HLA-DMA/HLA-DRB1/HLA-DPA1/FCGR3B/IL10/HLA-DMB/HLA-DQA1/CD86	6.23450189802977
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/257	238/9376	3.21904325932708	C1QC/NFKBIA/FOS/JUN/C1QB/IL1B/RPL12/TNF/C1QA/C5AR1/FCGR2A/RPL15/IL6/RPL36AL/CFD/HBEGF/RPL41/RPS29/RPL35A/RPS6/RPS14	5.82112951933081
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/257	70/9376	5.73296275708727	HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-DMA/HLA-DRB1/CYCS/HLA-DPA1/HLA-DMB/HLA-DQA1/CD86/ACTB	6.67235546549984
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	27/257	368/9376	2.67670444933175	TNF/PFN1/UQCR10/NDUFA4/COX6C/CYCS/COX7B/HSPA5/TUBA1A/COX7A2/NRBF2/PSMB3/GPX1/MAP1LC3B/TUBA1B/NDUFA12/COX6A1/NDUFB2/NDUFC2/NDUFB1/NDUFA1/COX6B1/UQCRQ/ACTB/NDUFA6/NDUFB3/NDUFB9	5.5086455562089
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	20/257	227/9376	3.21431632355714	CCL3/CCL4/CCL3L1/NFKBIA/IL1B/CCL4L2/CALM2/B2M/TNF/CDKN1A/CCL4L1/CYCS/IL6/CCL3L3/PTGS2/GRB2/CXCR4/CALM1/CXCR2/PDIA3	5.66949489284604
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/257	103/9376	4.6045861508821	CCL3/CCL3L1/C1QC/NFKBIA/FOS/JUN/C1QB/IL1B/TNF/C1QA/IL10/IL6/CCL3L3	6.17507851934185
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/257	173/9376	3.58498459323902	NFKBIA/DNAJB1/HLA-DQA2/IL1B/HLA-DRA/TNF/HLA-DPB1/HLA-DMA/HLA-DRB1/CYCS/HLA-DPA1/IL6/HLA-DMB/HLA-DQA1/SOCS3/SLC25A5/ACTB	5.76096042125742
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	13/257	105/9376	4.51687974800815	NFKBIA/JUN/IL1B/CALM2/TNF/FCER1G/IL10/IL6/EGR2/PTGS2/CALM1/PAK1/IRF1	6.08369551587536
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/257	193/9376	3.4025120461281	CCL3/CXCL3/CCL4/CCL3L1/NFKBIA/CXCL2/CCL4L2/CXCL1/CCL4L1/CDC42/CCL3L3/GRB2/CXCL14/CCL20/CXCR4/CCL13/PAK1/CXCR2	5.66148718023098
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	20/257	235/9376	3.10489278913817	UQCR10/NDUFA4/COX6C/COX7B/COX7A2/GRB2/COX16/NDUFA12/COX6A1/RPS6/NDUFB2/NDUFC2/NDUFB1/NDUFA1/COX6B1/UQCRQ/ACTB/NDUFA6/NDUFB3/NDUFB9	5.48587173301162
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	15/257	142/9376	3.85378418370143	NFKBIA/FOS/JUN/JUNB/IL1B/TNF/TREM2/TYROBP/FOSB/FCGR2A/CYBA/FCGR3B/GRB2/SOCS3/SPI1	5.75239838614875
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	15/257	142/9376	3.85378418370143	FOS/JUN/IL1B/CALM2/TNF/HSP90AB1/CYBA/MGST3/TXN/NFE2L2/CALM1/HMOX1/IL1R2/ACTB/PLAT	5.75239838614875
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	23/257	308/9376	2.72434180605387	UQCR10/NDUFA4/COX6C/CYCS/COX7B/TUBA1A/COX7A2/NRBF2/PSMB3/GPX1/TUBA1B/NDUFA12/COX6A1/NDUFB2/NDUFC2/SLC25A5/NDUFB1/NDUFA1/COX6B1/UQCRQ/NDUFA6/NDUFB3/NDUFB9	5.16560926298945
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	18/257	205/9376	3.20334060928158	UQCR10/NDUFA4/COX6C/CYBA/COX7B/COX7A2/NDUFA12/COX6A1/NDUFB2/NDUFC2/SLC25A5/NDUFB1/NDUFA1/COX6B1/UQCRQ/NDUFA6/NDUFB3/NDUFB9	5.35462195958704
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/257	200/9376	3.10101167315175	NFKBIA/FOS/JUN/IL1B/TNF/FCGR2A/ARPC2/CYCS/ARPC5/TUBA1A/CDC42/IL6/TUBA1B/EZR/ARPC3/PAK1/ACTB	5.0419130607831
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	11/257	93/9376	4.31513325802268	NFKBIA/FOS/JUN/HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/HLA-DMB/HLA-DQA1	5.39357697804744
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	16/257	187/9376	3.12149649389292	CXCL3/NFKBIA/JUN/CXCL2/IL1B/TNF/CXCL1/HSP90AB1/CYBA/TNFAIP3/IL6/TXN/MAP1LC3B/BIRC3/NAMPT/YWHAE	4.91934847316077
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	13/257	138/9376	3.4367563300062	NFKBIA/FOS/JUN/IL1B/TNF/FCGR2A/ARPC2/ARPC5/CDC42/IL10/IL6/ARPC3/ACTB	4.84106884910727
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	13/257	144/9376	3.29355814958928	CXCL3/C1QC/NFKBIA/CXCL2/C1QB/IL1B/CD14/TNF/C1QA/C5AR1/CXCL1/IL6/LY96	4.65609352927827
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/257	31/9376	7.06112714949165	HSPA5/SRP14/SEC61G/SEC61B/SPCS3/SPCS1	5.67444225369015
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	20/257	298/9376	2.44848928002507	CCL3/CXCL3/CCL4/CCL3L1/CXCL2/IL1B/CCL4L2/TNF/CXCL1/CCL4L1/IL10/IL6/CCL3L3/CXCL14/CCL20/CXCR4/PRLR/CCL13/CXCR2/IL1R2	4.26586316193966
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	15/257	201/9376	2.7225739009234	GADD45B/NFKBIZ/CD14/BCL2A1/CDKN1A/ID2/IL6/SPI1/CD86/GZMB/BIRC3/GADD45G/IL1R2/DDX5/PLAT	4.14430249316199
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	17/257	253/9376	2.45139262699743	NFKBIA/JUN/IL1B/CD14/TNF/UBB/PFN1/ARPC2/CYCS/ARPC5/UBC/CDC42/MAP1LC3B/TLN1/ARPC3/SKP1/ACTB	3.92875482798829
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/257	42/9376	5.21178432462479	FTL/FTH1/SLC40A1/MAP1LC3B/SAT1/HMOX1	4.59235510735195
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	14/257	204/9376	2.50370031280995	TNF/PLAUR/DCN/CDKN1A/CD63/CDC42/HBEGF/GRB2/EZR/RPS6/PAK1/THBS1/ACTB/DDX5	3.64521327134587
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/257	139/9376	2.8871035467346	FOS/JUN/CALM2/HSP90AB1/HSPA8/HSPA1A/HBEGF/GRB2/KRT10/CALM1/HSPA1B	3.76284432479429
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	9/257	103/9376	3.18779041214914	CXCL3/CXCL2/IL1B/CD14/TNF/CXCL1/IL10/IL6/IL1R2	3.74794137617662
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/257	51/9376	4.29205767910277	ATP6V0E1/ATP6V1F/SEC61G/ATP6V0B/SEC61B/ACTB	3.95737035001375
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/257	87/9376	3.35471174918377	FOS/JUN/GADD45B/CDKN1A/CYCS/GRB2/PMAIP1/GADD45G	3.70417492637975
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/257	88/9376	3.31659002476123	C1QC/VSIG4/C1QB/C1QA/C5AR1/PLAUR/CFD/PLAT	3.66528716999654
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/257	300/9376	2.0673411154345	FOS/JUN/GADD45B/IL1B/CD14/TNF/HSPA8/FGF7/NR4A1/HSPA1A/CDC42/GRB2/HSPA1B/PAK1/GADD45G/DUSP2/MAP3K8	3.15424348804278
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	15/257	250/9376	2.18894941634241	LGMN/NPC2/CD63/CTSS/CTSC/ATP6V0E1/ATP6V1F/ATP6V0B/CD68/AP1S2/VAMP8/ASAH1/LAPTM4A/LITAF/ARL8B	3.1986869768447
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/257	93/9376	3.1382787331074	NFKBIA/GADD45B/CDKN1A/CYCS/PTGS2/BIRC3/CKS2/GADD45G	3.47888608086162
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/257	136/9376	2.68253604943923	NFKBIA/FOS/JUN/IL1B/HSPA8/CYCS/HSPA1A/TNFAIP3/IL6/HSPA1B	3.31800043500523
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	13/257	214/9376	2.21622604458344	NFKBIA/FOS/JUN/CALM2/B2M/TNF/CYCS/AP1S2/CXCR4/CALM1/PAK1/SKP1/PDIA3	3.02137501994021
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	9/257	122/9376	2.69133124960133	NFKBIA/FOS/JUN/TNF/CDC42/IL10/GRB2/PAK1/MAP3K8	3.15662093796536
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/257	149/9376	2.44848928002507	NDUFA4/PTGS2/NDUFA12/NDUFB2/NDUFC2/NDUFB1/NDUFA1/NDUFA6/NDUFB3/NDUFB9	2.99196667058947
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/257	30/9376	4.86433203631647	FOLR2/IL1B/TNF/IL6	3.55877692871127
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	14/257	250/9376	2.04301945525292	FOLR2/DAB2/ARPC2/HSPA8/ARPC5/HSPA1A/SNX6/CDC42/CXCR4/HSPA1B/ARPC3/CXCR2/RAB10/SNX2	2.80608468472667
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/257	87/9376	2.9353727805358	UQCR10/COX6C/COX7B/COX7A2/COX6A1/COX6B1/UQCRQ	3.04451673515605
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/257	157/9376	2.32372549505564	C1QC/C1QB/C1QA/IL10/PTGS2/TIMD4/DUSP2/THBS1/BSG/SGK1	2.80791815083448
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/257	50/9376	3.64824902723735	IL1B/TNF/IL10/IL6/THBS1	3.15191654593484
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	7/257	93/9376	2.74599389146898	JUN/EGR1/CALM2/CDC42/HBEGF/GRB2/CALM1	2.84065578179968
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/257	75/9376	2.91859922178988	GADD45B/CDKN1A/CYCS/PMAIP1/GADD45G/THBS1	2.80045543226606
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	8/257	120/9376	2.43216601815824	NFKBIA/JUN/CALM2/ARHGDIB/CDC42/GRB2/CALM1/YWHAE	2.65064097243406
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/257	76/9376	2.88019660045054	GADD45B/CALM2/CDKN1A/GRB2/CALM1/GADD45G	2.76278555700879
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/257	98/9376	2.6058921623124	FCGR2A/ARPC2/ARPC5/FCGR3B/CDC42/ARPC3/PAK1	2.68275383437717
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/257	37/9376	3.94405300241876	IL1B/TNF/IL10/IL6	3.01213817858884
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	6/257	78/9376	2.8063454055672	BTG2/HSPD1/TOB1/BTG1/BTG3/LSM1	2.68925460659376
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/257	83/9376	2.63728845342459	CCL4/NFKBIA/IL1B/CCL4L2/CCL4L1/IL6	2.51515566294899
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/257	106/9376	2.40922105572278	NFKBIA/FOLR2/CDKN1A/HSP90AB1/GRB2/IL1R2/PLAT	2.44946242144869
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	9/257	160/9376	2.05214007782101	HLA-DQA2/HLA-DRA/HLA-DPB1/HLA-DMA/HLA-DRB1/HLA-DPA1/HLA-DMB/HLA-DQA1/CD86	2.25341361637924
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/257	163/9376	2.01437062853596	NFKBIA/FOS/JUN/TNF/CDKN1A/CYCS/IL6/EGR2/GRB2	2.19315094955136
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/257	46/9376	3.17239045846726	FTL/FTH1/HMOX1/BLVRB	2.47944553412537
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	7/257	115/9376	2.22067332092709	FOS/EGR1/NR4A2/CDKN1A/HBEGF/PDE4B/SGK1	2.21104724631039
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	5/257	69/9376	2.64365871538939	FOS/JUN/CALM2/FOSB/CALM1	2.30043479217147
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/257	70/9376	2.6058921623124	JUN/CDKN1A/CDC42/GRB2/PAK1	2.2639272472963
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	9/257	170/9376	1.93142595559625	JUN/ARPC2/ARPC5/TUBA1A/CDC42/TUBA1B/EZR/ARPC3/ACTB	2.05738658372228
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/257	71/9376	2.56918945580095	FOS/GRB2/SOCS3/PRLR/IRF1	2.22805013429356
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/257	148/9376	1.97202650120938	FOS/JUN/GADD45B/CDKN1A/FGF7/GRB2/HES1/GADD45G	2.00093860077538
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/257	52/9376	2.8063454055672	APOC1/NPC2/PLTP/APOE	2.19270360286238
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	11/257	232/9376	1.72977324567288	TMSB4X/PFN1/ARPC2/FGF7/ARPC5/CDC42/EZR/CXCR4/ARPC3/PAK1/ACTB	1.88948049617107
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/257	75/9376	2.43216601815824	CDKN1A/CYCS/MGST3/PMAIP1/BIRC3	2.09044028576038
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/257	32/9376	3.42023346303502	CYCS/PMAIP1/BIRC3	2.30220730514791
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/257	76/9376	2.40016383370879	PLTP/OLR1/UBC/DBI/FABP3	2.0574191104748
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	6/257	101/9376	2.16727664984397	JUN/EGR1/IL1B/TNF/CDC42/IL6	1.97995863782115
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	5/257	77/9376	2.36899287482945	NFKBIA/GADD45B/CDKN1A/GRB2/GADD45G	2.02491603039504
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	8/257	154/9376	1.89519429986356	FOS/JUN/CALM2/RGS2/CDKN1A/PTGS2/CALM1/ACTB	1.88037167970894
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/257	78/9376	2.338621171306	ARPC2/ARPC5/CDC42/ARPC3/ACTB	1.99291516468757
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	8/257	157/9376	1.85898039604451	GADD45B/CALM2/CDKN1A/IL6/SLC25A5/CALM1/GADD45G/ZFP36L2	1.82208974162199
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/257	133/9376	1.92013106696703	GADD45B/CDKN1A/IL10/IL6/GRB2/GADD45G/SGK1	1.7941040653345
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/257	133/9376	1.92013106696703	TNF/TYROBP/FCER1G/FCGR3B/GRB2/GZMB/PAK1	1.7941040653345
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/257	59/9376	2.47338917100838	GADD45B/CDKN1A/GRB2/GADD45G	1.90582940628938
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/257	37/9376	2.95803975181407	GADD45B/CDKN1A/GADD45G	2.00332204847814
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/257	110/9376	1.98995401485674	TNF/EMP3/DCN/ID2/THBS1/SKP1	1.7532498401056
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/257	61/9376	2.39229444409007	FTL/FTH1/SLC40A1/HMOX1	1.8313998319653
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/257	86/9376	2.12107501583567	JUN/CDKN1A/HBEGF/GRB2/PAK1	1.75329354814122
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/257	62/9376	2.35370904983055	HSPA8/HSPA1A/CRYAB/HSPA1B	1.79527776570573
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	8/257	168/9376	1.7372614415416	FTL/FTH1/IL1B/TNF/HSP90AB1/TNFAIP3/BIRC3/SLC25A5	1.61872136415046
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/257	170/9376	1.71682307164111	GADD45B/CDKN1A/MGST3/GRB2/NFE2L2/GADD45G/HMOX1/ACTB	1.58335953774548
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/257	41/9376	2.66945050773465	CDKN1A/HBEGF/THBS1	1.79840254212377
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/257	68/9376	2.14602883955138	CD14/BCL2A1/GRB2/SPI1	1.59221022193008
NA	NA	hsa04517	IgSF CAM signaling	12/257	299/9376	1.46418021160028	ARPC2/DYNLL1/ARPC5/TUBA1A/CDC42/GRB2/CD86/TUBA1B/EZR/ARPC3/PAK1/ACTB	1.36939784667255
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/257	69/9376	2.11492697231151	TNF/FCER1G/GRB2/ALOX5AP	1.56043147754562
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/257	23/9376	3.17239045846726	ATP6AP2/MME	1.75107573300158
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/257	99/9376	1.84255001375624	FOS/JUN/CDKN1A/HBEGF/GRB2	1.41477735882958
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	7/257	156/9376	1.6370348199142	NFKBIA/TNF/CDKN1A/CYCS/GRB2/SOCS3/YWHAE	1.34691007628909
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/257	73/9376	1.99904056286978	GADD45B/CDKN1A/FGF7/GADD45G	1.43850585311867
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/257	73/9376	1.99904056286978	GADD45B/CDKN1A/GRB2/GADD45G	1.43850585311867
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/257	76/9376	1.92013106696703	CALM2/EZR/CALM1/ACTB	1.3520526639408
Genetic Information Processing	Translation	hsa03010	Ribosome	9/257	222/9376	1.47901987590704	RPL12/RPL15/RPL36AL/RPL41/RPS29/RPL35A/RPS6/RPS14/MRPS14	1.21255978082104
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/257	77/9376	1.89519429986356	GADD45B/CDKN1A/CDC42/GADD45G	1.32410717501931
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	5/257	105/9376	1.7372614415416	JUN/UBB/UBC/TAX1BP1/MAP1LC3B	1.27535612455181
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/257	28/9376	2.6058921623124	ATP6V0E1/ATP6V1F	1.42861312023019
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/257	169/9376	1.51110906453618	UBB/UBC/NRBF2/TAX1BP1/MAP1LC3B/VAMP8/ATG3	1.12558022887697
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/257	140/9376	1.56353529738744	EGR1/CALM2/MAP1LC3B/RPS6/CALM1/PLAT	1.12777320341176
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/257	29/9376	2.51603381188783	RASSF4/PAK1	1.3726201089256
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/257	29/9376	2.51603381188783	CALM2/CALM1	1.3726201089256
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	8/257	203/9376	1.43773360679305	JUN/CDC42/GRB2/TLN1/BIRC3/PAK1/THBS1/ACTB	1.05847548729521
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	6/257	142/9376	1.54151367348057	UBB/UBC/SOCS3/BIRC3/SKP1/UBE2B	1.09153397064766
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	8/257	205/9376	1.42370693745848	NFKBIA/JUN/CDKN1A/CDC42/EGR2/GRB2/PMAIP1/YWHAE	1.02970483192079
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	5/257	116/9376	1.57252113242989	CYBA/CDC42/EZR/CXCR4/ACTB	1.04158235697375
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/257	59/9376	1.85504187825628	HPGDS/MGST3/GPX1	1.10599696757271
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	8/257	212/9376	1.3766977461273	CALM2/PFN1/FGF7/CDC42/TLN1/CALM1/THBS1/ACTB	0.931315870789694
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/257	33/9376	2.21106001650749	VAMP8/VAMP5	1.16992508639902
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/257	34/9376	2.14602883955138	BHLHE40/SKP1	1.1238120015285
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	4/257	91/9376	1.6036259460384	NFKBIA/FOS/JUN/GRB2	0.971351092997226
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/257	63/9376	1.7372614415416	GADD45B/CDKN1A/GADD45G	0.985656491131278
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/257	93/9376	1.5691393665537	CST3/CALM2/CALM1/LYZ	0.925964884613862
Organismal Systems	Immune system	hsa04611	Platelet activation	5/257	126/9376	1.44771786795133	FCER1G/FCGR2A/VAMP8/TLN1/ACTB	0.849370992839494
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/257	158/9376	1.38541102300153	TNF/GRB2/ATP6V1F/RPS6/CAB39L/SGK1	0.820187063779362
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	4/257	98/9376	1.48908123560708	CALM2/NR4A2/NR4A1/CALM1	0.817044002666716
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	12/257	362/9376	1.20936431842122	CDKN1A/HSP90AB1/LPAR6/FGF7/NR4A1/IL6/GRB2/PRLR/RPS6/YWHAE/THBS1/SGK1	0.681988054960882
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/257	70/9376	1.56353529738744	NFKBIA/TNF/SOCS3	0.794451174561781
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/257	70/9376	1.56353529738744	HPGDS/MGST3/PTGS2	0.794451174561781
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	11/257	333/9376	1.20512730629462	TNF/CDKN1A/CDC42/ATP6V0E1/PTGS2/GRB2/ATP6V1F/ATP6V0B/HES1/THBS1/IRF1	0.639834892901041
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/257	103/9376	1.41679573873295	CPB1/MME/SLC7A8/COL15A1	0.714019947220083
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/257	168/9376	1.3029460811562	CDKN1A/IL10/IL6/GRB2/SOCS3/PRLR	0.665144365515458
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/257	138/9376	1.32182935769469	CALM2/GRB2/SOCS3/RPS6/CALM1	0.639373768759232
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/257	44/9376	1.65829501238062	OSTC/TMEM258	0.734747521633888
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/257	44/9376	1.65829501238062	DYNLL1/ARHGDIB	0.734747521633888
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/257	243/9376	1.20106963859666	HSPA8/HSPA1A/HNRNPC/SNRPB2/RNU2-63P/HSPA1B/SNRPG/DDX5	0.533115730483688
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/257	109/9376	1.33880698247242	NFKBIA/TNF/IL6/SOCS3	0.597275377693829
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/257	110/9376	1.32663600990449	CDKN1A/IL6/RPS6/HMOX1	0.578485993837457
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/257	46/9376	1.58619522923363	PSMB3/POMP	0.669050601646633
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/257	79/9376	1.38541102300153	ATP6V0E1/ATP6V1F/ATP6V0B	0.577490512641107
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/257	47/9376	1.55244639456909	TNF/SOCS3	0.637382474655039
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/257	80/9376	1.36809338521401	IL6/GRB2/RPS6	0.555051832809915
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/257	217/9376	1.17685452491528	FOS/JUN/HSP90AB1/FGF7/MGST3/GRB2/KLF4	0.442487091145215
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/257	49/9376	1.48908123560708	JUN/FOSB	0.576217766020811
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/257	150/9376	1.21608300907912	GADD45B/CDKN1A/FGF7/GRB2/GADD45G	0.447855709729643
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/257	18/9376	2.02680501513186	TCN2	0.732000377999929
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/257	51/9376	1.43068589303426	PLD3/PLA2G7	0.517725917769303
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/257	226/9376	1.12998863675493	NFKBIA/FOS/JUN/CALM2/PDE4B/CALM1/PAK1	0.332068479585621
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/257	122/9376	1.19614722204503	FOS/JUNB/GRB2/SOCS3	0.366079931519648
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	5/257	158/9376	1.15450918583461	GADD45B/CDKN1A/GADD45G/YWHAE/SKP1	0.328808539179023
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/257	89/9376	1.22974686311371	TUBA1A/GRB2/TUBA1B	0.36558255433668
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/257	195/9376	1.12253816222688	C5AR1/FCGR2A/CYBA/FCGR3B/SLC25A5/ACTB	0.290283443772517
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/257	125/9376	1.16743968871595	TNF/FCER1G/SPTSSA/ASAH1	0.316371727547233
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/257	90/9376	1.21608300907912	NFKBIA/FOS/JUN	0.345784981083292
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/257	56/9376	1.3029460811562	OSTC/TMEM258	0.381706880346313
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/257	93/9376	1.17685452491528	CDC42/PDCD10/ACTB	0.287734585551922
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/257	23/9376	1.58619522923363	IDI1	0.472508170302194
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/257	130/9376	1.12253816222688	NFKBIA/FOS/JUN/GRB2	0.236180852737276
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/257	60/9376	1.21608300907912	CDC42/PTGS2	0.28187729571312
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/257	97/9376	1.12832444141361	FOS/CALM2/CALM1	0.213266800845763
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/257	99/9376	1.10553000825374	IL1B/CALM2/CALM1	0.177201903645913
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	3/257	99/9376	1.10553000825374	FOS/JUN/GRB2	0.177201903645913
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	3/257	99/9376	1.10553000825374	TNF/IL6/ACTB	0.177201903645913
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/257	26/9376	1.4031727027836	HES1	0.345581575820825
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/257	26/9376	1.4031727027836	TCN2	0.345581575820825
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/257	63/9376	1.15817429436106	HPGDS/PTGS2	0.21146571783423
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/257	138/9376	1.05746348615575	CALM2/CALM1/YWHAE/SKP1	0.114161883715728
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/257	27/9376	1.35120334342124	HADHA	0.306786705653475
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/257	28/9376	1.3029460811562	HADHA	0.269502994297491
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/257	28/9376	1.3029460811562	AKR1B1	0.269502994297491
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/257	67/9376	1.08902956036936	CALM2/CALM1	0.122771823689748
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/257	144/9376	1.01340250756593	CYCS/NRBF2/PSMB3/SLC25A5	0.027208086598987
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/257	69/9376	1.05746348615575	CALM2/CALM1	0.0804248482939147
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/257	31/9376	1.17685452491528	HADHA	0.16557164437966
NA	NA	hsa04981	Folate transport and metabolism	1/257	31/9376	1.17685452491528	FOLR2	0.16557164437966
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/257	149/9376	0.979395712010028	FCER1G/LPAR6/GRB2/CXCR2	-0.0425597508986439
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/257	32/9376	1.14007782101167	AKR1B1	0.133246725056792
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/257	32/9376	1.14007782101167	HADHA	0.133246725056792
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/257	32/9376	1.14007782101167	ATG3	0.133246725056792
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/257	72/9376	1.01340250756593	NFKBIA/TNF	0.019164436340958
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/257	73/9376	0.999520281434891	HPGDS/MGST3	-0.000690740686019758
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/257	73/9376	0.999520281434891	CXCR4/ELL2	-0.000690740686019758
NA	NA	hsa04518	Integrin signaling	4/257	154/9376	0.94759714993178	CDC42/TLN1/THBS1/ACTB	-0.11007312626916
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/257	75/9376	0.972866407263294	HSPA5/GPX1	-0.0396051537566627
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/257	35/9376	1.04235686492496	AKR1B1	0.0421443864989891
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/257	157/9376	0.929490198022256	ID2/BIRC3/YWHAE/ACTB	-0.149567076802982
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/257	36/9376	1.01340250756593	AKR1B1	0.0135251616790867
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/257	36/9376	1.01340250756593	C1GALT1	0.0135251616790867
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	6/257	238/9376	0.919726645522022	CALM2/FGF7/CDC42/GRB2/CALM1/PAK1	-0.210577955793961
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/257	79/9376	0.923607348667685	HPGDS/MGST3	-0.114464892665349
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/257	38/9376	0.960065533483514	GNPDA1	-0.0414086758090697
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/257	38/9376	0.960065533483514	NAMPT	-0.0414086758090697
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/257	38/9376	0.960065533483514	SGK1	-0.0414086758090697
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	4/257	166/9376	0.879096151141531	CALM2/RGS2/SLC25A5/CALM1	-0.263841402791949
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/257	42/9376	0.868630720770799	HADHA	-0.143239618631496
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/257	43/9376	0.848430006334268	HADHA	-0.167230473466173
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	3/257	133/9376	0.822913314414441	FOS/CALM2/CALM1	-0.345289876553042
NA	NA	hsa04382	Cornified envelope formation	5/257	217/9376	0.840610374939483	S100A8/S100A11/S100A9/S100A4/KRT10	-0.398790201073691
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/257	134/9376	0.816772170277019	CALM2/RAMP1/CALM1	-0.358624079600938
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/257	48/9376	0.760051880674449	HADHA	-0.279783624715435
NA	NA	hsa03272	Virion - Hepatitis viruses	1/257	48/9376	0.760051880674449	CD63	-0.279783624715435
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/257	49/9376	0.744540617803542	C1GALT1	-0.300972975042856
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/257	50/9376	0.729649805447471	SAT1	-0.321767795491556
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/257	98/9376	0.744540617803542	CALM2/CALM1	-0.426762551806921
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/257	144/9376	0.760051880674449	ID2/GRB2/KLF4	-0.487112518143156
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/257	52/9376	0.701586351391799	PTGS2	-0.362241175153901
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/257	101/9376	0.722425549947991	CALM2/CALM1	-0.470827485577127
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	5/257	233/9376	0.782886057347072	DCN/TLN1/LMOD1/THBS1/ACTB	-0.563378029654838
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/257	191/9376	0.76403120989264	CALM2/FOSB/GRB2/CALM1	-0.553108408882372
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/257	54/9376	0.675601671710621	HES1	-0.401328064063747
Cellular Processes	Cell motility	hsa04814	Motor proteins	4/257	194/9376	0.752216294275743	DYNLL1/TUBA1A/TUBA1B/ACTB	-0.585441569587644
NA	NA	hsa04519	Cadherin signaling	9/257	404/9376	0.81272874369149	NFKBIA/ARPC2/LIMA1/ARPC5/CDC42/KRT10/ARPC3/YWHAE/ACTB	-0.645945334930684
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/257	55/9376	0.663318004952246	ASAH1	-0.420386319758543
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/257	105/9376	0.694904576616639	TNF/ACTB	-0.527771147194524
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/257	57/9376	0.640043688989009	HADHA	-0.457594879778324
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/257	107/9376	0.681915706025674	CALM2/CALM1	-0.555515607635192
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/257	154/9376	0.710697862448835	CALM2/CREM/CALM1	-0.607684327763687
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/257	59/9376	0.618347292752094	PTGS2	-0.493667909860645
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/257	62/9376	0.588427262457638	HES1	-0.54582436659704
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/257	63/9376	0.579087147180532	HADHA	-0.562725055462818
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/257	254/9376	0.718159257330188	CALM2/FGF7/CXCR4/SLC25A5/CALM1	-0.76445898759393
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/257	117/9376	0.623632312348266	MORF4L2/ACTB	-0.687704413675686
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/257	65/9376	0.561269081113439	AKR1B1	-0.595847811735331
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/257	65/9376	0.561269081113439	NR4A1	-0.595847811735331
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/257	122/9376	0.598073611022517	CAB39L/RAB10	-0.750136471058635
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/257	178/9376	0.614873431556857	JUN/SKP1/CACYBP	-0.870854039258092
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/257	323/9376	0.677693317753069	CDKN1A/PTGS2/GRB2/EZR/HMOX1/THBS1	-0.989584541881039
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/257	184/9376	0.594823210962612	CDC42/CXCR4/PAK1	-0.931809328818648
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/257	82/9376	0.444908417955775	MGST3	-0.847517794534768
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/257	83/9376	0.439548075570766	SKP1	-0.860950206171947
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/257	86/9376	0.424215003167134	ACTB	-0.900492924919088
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/257	89/9376	0.409915621037905	THBS1	-0.938966267532289
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/257	91/9376	0.400906486509599	PDE4B	-0.964057530919043
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/257	155/9376	0.47074180996611	CDKN1A/NR4A1	-1.11538042247286
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/257	102/9376	0.357671473258564	CPB1	-1.09497030675781
NA	NA	hsa04081	Hormone signaling	3/257	219/9376	0.499760140717446	SLC40A1/RAMP1/PRLR	-1.25748361769815
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/257	104/9376	0.350793175695899	PLD3	-1.11761346768695
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/257	110/9376	0.331659002476123	HSP90AB1	-1.18365977556475
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/257	115/9376	0.317239045846726	FOS	-1.23670821806961
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/257	115/9376	0.317239045846726	PTGS2	-1.23670821806961
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/257	116/9376	0.314504226485979	ESD	-1.24711606791163
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	2/257	183/9376	0.398715740681678	SBDS/REXO2	-1.37897166259615
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/257	122/9376	0.299036805511259	ACTB	-1.30824467234778
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/257	128/9376	0.285019455252918	PDE4B	-1.36726875928652
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/257	370/9376	0.295803975181407	C5AR1/LPAR6/PRLR	-2.32010185805969
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/257	449/9376	0.243758286897819	CALM2/RGS2/CALM1	-2.75682769994581