category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04518	Integrin signaling	11/95	154/9376	7.04962406015038	FN1/FLT1/LAMB1/COL6A3/PDGFRA/LAMA2/FBN1/THBS1/COL6A2/IGF1/FERMT2	7.65819187347269
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	12/95	233/9376	5.0829907386492	FN1/VCAN/LMOD1/TPM1/COL6A3/FBLN1/LAMA2/FBN1/THBS1/COL6A2/TPM4/NID1	6.38501688325084
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	11/95	203/9376	5.34799066632098	FN1/FLT1/LAMB1/COL6A3/PDGFRA/LAMA2/THBS1/COL6A2/PAK3/IGF1/JUN	6.33623067750756
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	9/95	205/9376	4.33293966623877	MT-ND3/MT-CO1/MMP2/MT-CYB/MT-CO3/MT-ND1/INSR/MT-ND6/MT-ND5	4.88141903489803
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/95	88/9376	6.72918660287081	SERPINE2/C1S/C1R/SERPING1/F2R/CFD	5.46290005306203
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/95	89/9376	6.65357776463631	FN1/LAMB1/COL6A3/LAMA2/THBS1/COL6A2	5.42164035577724
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	12/95	362/9376	3.27164873509741	FN1/FLT1/LAMB1/COL6A3/IGF2/PDGFRA/LAMA2/THBS1/INSR/COL6A2/IGF1/F2R	4.45950587298893
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/95	95/9376	6.23335180055402	FLT1/CCL3/CXCL3/CCL3L1/HLA-DQA2/JUN	5.18673907713899
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/95	138/9376	5.00625476735317	MT-ND3/MT-CO1/MT-CYB/MT-CO3/MT-ND1/MT-ND6/MT-ND5	4.79666272591462
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/95	87/9376	5.67211131276467	TPM1/MT-CO1/MT-CYB/MT-CO3/TPM4	4.42933349571609
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/95	227/9376	3.47822861117552	MT-ND3/MT-CO1/MT-CYB/MT-CO3/MT-ND1/MT-ND6/MT-ND5/JUN	3.82399693854939
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/95	99/9376	4.98458266879319	KRT19/C1S/C1R/HLA-DQA2/CFD	4.03224317172529
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/95	100/9376	4.93473684210526	CXCL14/CCL3/CXCL3/CCL3L1/LTBR	4.00207641086581
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	4/95	62/9376	6.36740237691002	INSR/IRS2/IGF1/FOXO1	4.28984831911399
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/95	101/9376	4.88587806149036	FN1/MMP2/JUN/FOXO1/EGR1	3.97230832638292
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	5/95	103/9376	4.79100664282064	COL6A3/CPB1/COL6A2/COL15A1/MME	3.91393025492678
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	5/95	110/9376	4.48612440191388	FLT1/INSR/IGF1/LTBR/EPAS1	3.72085828869247
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/95	157/9376	3.77177338250084	MT-CO1/MT-CYB/MT-CO3/INSR/IRS2/JUN	3.54336338500995
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	10/95	388/9376	2.54367878459034	MT-ND3/MT-CO1/MT-CYB/MT-CO3/MT-ND1/INSR/IRS2/MT-ND6/MT-ND5/MME	3.14189249560105
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	9/95	333/9376	2.6674253200569	FN1/LAMB1/COL6A3/HLA-G/TCF7L2/LAMA2/THBS1/COL6A2/FOXO1	3.1344568665728
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	8/95	275/9376	2.87111961722488	MT-ND3/MT-CO1/MT-CYB/MT-CO3/MT-ND1/MT-ND6/MT-ND5/EGR1	3.18620266302789
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/95	78/9376	5.0612685560054	C1S/C1R/SERPING1/JUN	3.6438819063322
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	7/95	235/9376	2.93984322508399	MT-ND3/MT-CO1/MT-CYB/MT-CO3/MT-ND1/MT-ND6/MT-ND5	3.04686886957296
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/95	308/9376	2.5634996582365	MT-ND3/MT-CO1/MT-CYB/MT-CO3/TGM2/MT-ND1/MT-ND6/MT-ND5	2.82271770748283
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/95	90/9376	4.38643274853801	INSR/IRS2/IGF1/FOXO1	3.26587399698915
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/95	93/9376	4.24493491794001	MMP2/MMP14/JUN/EGR1	3.18165689622589
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/95	52/9376	5.69392712550607	INSR/IGF1/HSD3B1	3.43389440934156
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/95	204/9376	2.90278637770898	FN1/TIMP3/MMP2/IGF2/THBS1/IGF1	2.77986143609438
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/95	99/9376	3.98766613503456	TPM1/LAMA2/IGF1/TPM4	3.02340229172272
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	7/95	268/9376	2.57784760408484	MT-ND3/MT-CO1/MT-CYB/MT-CO3/MT-ND1/MT-ND6/MT-ND5	2.65137401270789
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/95	103/9376	3.83280531425651	FN1/LAMB1/CXCL3/LAMA2	2.92465919224466
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	6/95	212/9376	2.79324726911619	FLT1/PDGFRA/THBS1/INSR/IGF1/F2R	2.67187184046432
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/95	105/9376	3.75979949874687	TPM1/LAMA2/IGF1/TPM4	2.87712641912532
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	4/95	106/9376	3.72432969215492	PDGFRA/TCF7L2/IGF1/FOXO1	2.85379507294529
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	6/95	232/9376	2.5524500907441	TMSB4X/FN1/GSN/PDGFRA/PAK3/F2R	2.42238732457472
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/95	298/9376	2.31833274461321	CXCL14/CCL3/EBI3/CXCL3/CCL3L1/LTBR/IL33	2.33985064323187
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/95	119/9376	3.31747014595312	MMP14/CXCL3/JUNB/JUN	2.57396449227495
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	6/95	238/9376	2.48810260946484	FLT1/IGF2/PDGFRA/INSR/PAK3/IGF1	2.35258776688562
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/95	70/9376	4.22977443609023	PAK3/JUN/EPAS1	2.74403561089961
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/95	70/9376	4.22977443609023	HLA-G/LAMA2/HLA-DQA2	2.74403561089961
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	4/95	122/9376	3.23589301121657	INSR/IRS2/IGF1/FOXO1	2.51487405662714
Human Diseases	Immune disease	hsa05310	Asthma	2/95	32/9376	6.16842105263158	PRG2/HLA-DQA2	2.96289673647989
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	4/95	133/9376	2.96826276216858	INSR/IRS2/IGF1/FOXO1	2.31287666540965
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	5/95	201/9376	2.45509295627128	HPGD/FLT1/PBX1/IGF1/FOXO1	2.10977326748191
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/95	37/9376	5.3348506401138	AOX1/ADH1B	2.67285172413401
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/95	38/9376	5.19445983379501	INSR/IGF1	2.62114446567672
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/95	144/9376	2.74152046783626	CXCL3/TCF7L2/FOXO1/ADH1B	2.13064936846641
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/95	39/9376	5.0612685560054	HLA-G/HLA-DQA2	2.57122680688553
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	4/95	149/9376	2.64952313670081	MT-ND3/MT-ND1/MT-ND6/MT-ND5	2.05338951393742
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/95	41/9376	4.81437740693196	MMP2/THBS1	2.47632979494542
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/95	42/9376	4.69974937343358	AOC1/AOX1	2.43115756531651
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/95	93/9376	3.18370118845501	FN1/LAMB1/LAMA2	2.14111781013938
NA	NA	hsa04081	Hormone signaling	5/95	219/9376	2.25330449411199	IGF2/INSR/TRH/IRS2/IGF1	1.89868142560425
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/95	155/9376	2.54696095076401	HLA-G/THBS1/C1R/HLA-DQA2	1.96474523295121
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/95	44/9376	4.48612440191388	HLA-G/HLA-DQA2	2.34494093727984
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/95	45/9376	4.38643274853801	HLA-G/HLA-DQA2	2.30374641299796
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/95	224/9376	2.20300751879699	HLA-G/HLA-DQA2/LTBR/JUN/EGR1	1.84367513963841
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/95	99/9376	2.99074960127592	MMP2/IGF1/JUN	2.01456141172015
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	7/95	368/9376	1.87734553775744	MT-ND3/MT-CO1/MT-CYB/MT-CO3/MT-ND1/MT-ND6/MT-ND5	1.73712250463555
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	5/95	227/9376	2.1738928819847	CCL3/HLA-G/AKAP13/CCL3L1/PDGFRA	1.81135943901685
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/95	47/9376	4.19977603583427	INSR/IRS2	2.22485144667729
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/95	300/9376	1.97389473684211	FLT1/IGF2/PDGFRA/INSR/IGF1/JUN	1.73450460447077
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/95	103/9376	2.87460398569239	CCL3/CCL3L1/JUN	1.93538812956253
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/95	50/9376	3.94778947368421	HLA-DQA2/LTBR	2.11438376179245
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	5/95	238/9376	2.0734188412207	C1S/C1R/RPS18/CFD/JUN	1.69700128105314
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/95	109/9376	2.71636890391115	CCL3/CCL3L1/JUN	1.82349408805266
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/95	109/9376	2.71636890391115	EBI3/HLA-DQA2/JUN	1.82349408805266
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	3/95	109/9376	2.71636890391115	INSR/IRS2/FOXO1	1.82349408805266
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/95	54/9376	3.65536062378168	HLA-G/HLA-DQA2	1.97977527417592
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/95	112/9376	2.64360902255639	LAMB1/LAMA2/HLA-DQA2	1.77034663285591
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	4/95	178/9376	2.21785925487877	NOTUM/APCDD1/TCF7L2/JUN	1.65962685564124
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	6/95	323/9376	1.83333876486883	TIMP3/TPM1/PDGFRA/THBS1/IRS2/SOX4	1.54197254135974
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/95	115/9376	2.57464530892448	MMP14/AKAP13/EGR1	1.7189085677059
NA	NA	hsa04519	Cadherin signaling	7/95	404/9376	1.71005732152163	KRT19/KRT8/PDGFRA/TCF7L2/KRT7/LHFPL3/CDH11	1.47601072943132
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/95	59/9376	3.34558429973238	INSR/IRS2	1.82847513390859
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/95	122/9376	2.42691975841242	IRS2/JUNB/IGF1	1.60496207256694
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/95	193/9376	2.04548677392964	CXCL14/CCL3/CXCL3/CCL3L1	1.48475555889431
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/95	63/9376	3.13316624895572	HPGD/PTGDS	1.71870061114334
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	4/95	196/9376	2.01417830290011	HLA-G/CXCL3/TCF7L2/JUN	1.45168057214467
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/95	65/9376	3.03676113360324	PBX1/HSD3B1	1.66705016363158
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/95	66/9376	2.99074960127592	HLA-DQA2/JUN	1.64196471156004
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/95	68/9376	2.90278637770898	AOX1/ADH1B	1.59318554408129
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/95	205/9376	1.92575096277279	GSN/HLA-G/LTBR/JUN	1.35585363786496
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/95	71/9376	2.78013343217198	CXCL3/JUN	1.52325845276125
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/95	138/9376	2.14553775743707	INSR/IRS2/FOXO1	1.37154489200308
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/95	139/9376	2.13010223400227	MMP2/KRT19/JUN	1.35803110161796
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/95	73/9376	2.70396539293439	AOX1/ADH1B	1.4786341905969
Human Diseases	Cancer: specific types	hsa05218	Melanoma	2/95	73/9376	2.70396539293439	PDGFRA/IGF1	1.4786341905969
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	4/95	216/9376	1.82768031189084	CCL3/CXCL3/CCL3L1/JUN	1.24506440689984
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/95	75/9376	2.63185964912281	THBS1/IGF1	1.43548502999728
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/95	143/9376	2.07051895472948	C1S/C1R/HLA-DQA2	1.30509166734345
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/95	76/9376	2.59722991689751	PDGFRA/IGF1	1.41443440776997
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/95	78/9376	2.5306342780027	HLA-DQA2/JUN	1.3733271941789
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/95	148/9376	2.00056899004267	TCF7L2/IGF1/JUN	1.24129257685774
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/95	149/9376	1.98714235252561	PDGFRA/INSR/F2R	1.22883257005643
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/95	80/9376	2.46736842105263	PDGFRA/IGF1	1.33347893326528
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/95	22/9376	4.48612440191388	AOC1	1.65617259086261
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/95	82/9376	2.40718870346598	HLA-G/HLA-DQA2	1.29481578940909
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/95	155/9376	1.91022071307301	TCF7L2/PBX1/HSD3B1	1.15604198416283
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/95	23/9376	4.29107551487414	MME	1.59873452150672
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	3/95	157/9376	1.88588669125042	HLA-G/ZFP36L1/FOXO1	1.13249462775783
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	7/95	480/9376	1.43929824561404	MT-ND3/MT-CO1/MT-CYB/MT-CO3/MT-ND1/MT-ND6/MT-ND5	0.999614978164952
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/95	86/9376	2.29522643818849	PAK3/JUN	1.22077920776376
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/95	86/9376	2.29522643818849	TCF7L2/LAMA2	1.22077920776376
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/95	87/9376	2.26884452510587	TCF7L2/JUN	1.2029113134682
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/95	160/9376	1.85052631578947	VCAN/HLA-G/HLA-DQA2	1.097808447454
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	2/95	93/9376	2.12246745897001	TCF7L2/INSR	1.10057872405288
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/95	93/9376	2.12246745897001	HLA-DQA2/JUN	1.10057872405288
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	2/95	94/9376	2.09988801791713	CXCL3/JUN	1.08428055692848
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/95	99/9376	1.99383306751728	PDGFRA/JUN	1.00572053171758
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/95	100/9376	1.97389473684211	HLA-DQA2/MME	0.990562090779306
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/95	31/9376	3.18370118845501	PRPS2	1.23206737888443
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/95	105/9376	1.87989974937343	CXCL3/LTBR	0.917306788501688
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/95	34/9376	2.90278637770898	RORB	1.12450040229605
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/95	187/9376	1.5833380242049	TXNIP/CXCL3/JUN	0.815186574093816
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	2/95	110/9376	1.79444976076555	FBN1/THBS1	0.847943055523603
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/95	37/9376	2.6674253200569	TCF7L2	1.02812784374545
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5/95	370/9376	1.33371266002845	P2RY14/S1PR3/TRH/TAC3/F2R	0.662609453935119
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/95	38/9376	2.59722991689751	AOX1	0.998119072057321
NA	NA	hsa04082	Neuroactive ligand signaling	3/95	199/9376	1.4878603544036	P2RY14/TAC3/SLC6A2	0.703755421931541
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	3/95	200/9376	1.48042105263158	PAK3/F2R/JUN	0.694800912828712
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	3/95	205/9376	1.44431322207959	HLA-G/HLA-DQA2/JUN	0.650740558458345
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	2/95	122/9376	1.61794650560828	PAK3/JUN	0.695050088506736
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/95	43/9376	2.29522643818849	ADH1B	0.86123039752722
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/95	214/9376	1.38357107722577	HLA-G/PAK3/JUN	0.57425878755229
NA	NA	hsa04382	Cornified envelope formation	3/95	217/9376	1.36444336648072	KRT19/KRT8/KRT7	0.549523085176207
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/95	130/9376	1.51838056680162	MMP2/JUN	0.602134481966456
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/95	47/9376	2.09988801791713	ADH1B	0.76476835267251
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/95	48/9376	2.05614035087719	AOX1	0.742160848436338
Genetic Information Processing	Translation	hsa03010	Ribosome	3/95	222/9376	1.33371266002845	MT-RNR2/MT-RNR1/RPS18	0.509089067059363
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/95	49/9376	2.01417830290011	JUN	0.720097695810566
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/95	50/9376	1.97389473684211	AOC1	0.698553012573337
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/95	50/9376	1.97389473684211	THBS1	0.698553012573337
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/95	137/9376	1.44079907798694	PTPN13/JUN	0.525821732741181
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	2/95	138/9376	1.43035850495805	FN1/JUN	0.515265433525195
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/95	142/9376	1.39006671608599	JUNB/JUN	0.473847054867172
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	2/95	142/9376	1.39006671608599	MMP2/JUN	0.473847054867172
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/95	54/9376	1.82768031189084	REV3L	0.617099237567976
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/95	56/9376	1.76240601503759	CXCL3	0.578925162019753
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/95	59/9376	1.67279214986619	TCF7L2	0.524467918914527
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/95	60/9376	1.64491228070175	IGF1	0.507004234773061
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	3/95	248/9376	1.19388794567063	TCF7L2/PAK3/JUN	0.313068151038265
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/95	154/9376	1.28174982911825	TPM1/TPM4	0.356665840761693
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	2/95	157/9376	1.25725779416695	PBX1/THBS1	0.32887170867379
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/95	63/9376	1.56658312447786	TCF7L2	0.456498298142639
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	3/95	254/9376	1.16568586821384	FLT1/PDGFRA/F2R	0.270836595996284
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/95	158/9376	1.24930046635576	INSR/IGF1	0.31972996270267
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/95	65/9376	1.51838056680162	TRPC4	0.424284612688612
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/95	66/9376	1.49537480063796	HSD3B1	0.408583752131508
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/95	67/9376	1.47305577376276	ADH1B	0.393140954938939
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/95	68/9376	1.45139318885449	TCF7L2	0.377947367925565
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/95	166/9376	1.18909321496512	INSR/IRS2	0.248685365683025
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/95	69/9376	1.43035850495805	JUN	0.362994573789193
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	2/95	168/9376	1.1749373433584	PDGFRA/AOX1	0.231475252759065
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/95	70/9376	1.40992481203008	IRS2	0.348274563521387
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/95	71/9376	1.39006671608599	PDGFRA	0.333779710936524
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/95	170/9376	1.16111455108359	IGF2/TCF7L2	0.214473577221145
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	2/95	173/9376	1.14097961667174	HLA-DQA2/IL33	0.189349743188505
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/95	75/9376	1.3159298245614	PRPS2	0.277911482112658
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/95	75/9376	1.3159298245614	REV3L	0.277911482112658
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/95	76/9376	1.29861495844875	FABP5	0.26443987020049
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	2/95	180/9376	1.0966081871345	HLA-G/HLA-DQA2	0.132403894139184
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/95	78/9376	1.26531713900135	PABPC1	0.23804983810225
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/95	78/9376	1.26531713900135	FN1	0.23804983810225
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/95	79/9376	1.24930046635576	ADH1B	0.225120619699944
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/95	79/9376	1.24930046635576	SLC6A2	0.225120619699944
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	2/95	184/9376	1.07276887871854	TRPC4/PAK3	0.100855512635312
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/95	83/9376	1.18909321496512	IL33	0.175060061986473
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/95	194/9376	1.01747151383614	TPM1/TPM4	0.0248778480984772
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/95	89/9376	1.10892962743938	PDGFRA	0.104460801398942
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/95	90/9376	1.0966081871345	JUN	0.0931688858711417
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/95	91/9376	1.08455754771544	JUN	0.0820034597872347
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/95	93/9376	1.061233729485	CST3	0.060039637966382
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/95	98/9376	1.00708915145005	GSN	0.00713723773278916
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/95	98/9376	1.00708915145005	HSD3B1	0.00713723773278916
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/95	99/9376	0.996916533758639	IGF1	-0.00312034828499086
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/95	101/9376	0.977175612298072	TCF7L2	-0.0233320510521082
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/95	102/9376	0.967595459236326	CPB1	-0.0332906646250709
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/95	103/9376	0.958201328564129	PABPC1	-0.0431539958017269
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/95	105/9376	0.939949874686717	JUN	-0.06260302681013
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/95	105/9376	0.939949874686717	JUN	-0.06260302681013
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/95	107/9376	0.922380718150516	FOXO1	-0.0816949332958714
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	2/95	226/9376	0.873404750815091	F2R/JUN	-0.194899684014757
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/95	110/9376	0.897224880382775	IGF1	-0.109695355532685
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/95	116/9376	0.850816696914701	PRPS2	-0.163566279197084
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/95	116/9376	0.850816696914701	MMP2	-0.163566279197084
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/95	117/9376	0.843544759334233	MORF4L2	-0.172286424587245
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/95	120/9376	0.822456140350877	JUN	-0.198031675244696
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/95	122/9376	0.808973252804142	FOXO1	-0.214861895553464
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	1/95	125/9376	0.789557894736842	S1PR3	-0.239631197677841
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	2/95	250/9376	0.789557894736842	HLA-G/PDGFRA	-0.341202704159261
Organismal Systems	Immune system	hsa04611	Platelet activation	1/95	126/9376	0.783291562238931	F2R	-0.247765185618032
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/95	128/9376	0.771052631578947	PRPS2	-0.263855884841521
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	2/95	253/9376	0.780195548158935	JUN/FOXO1	-0.358573311385022
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/95	133/9376	0.742065690542145	HLA-G	-0.303094818954121
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/95	134/9376	0.736527886881382	CALD1	-0.310780761299269
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/95	136/9376	0.725696594427245	JUN	-0.325997840086282
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/95	138/9376	0.715179252479024	IGF1	-0.34101402495269
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/95	140/9376	0.704962406015038	EGR1	-0.355835659427783
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	1/95	144/9376	0.685380116959064	IGF1	-0.384919194168882
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/95	150/9376	0.657964912280702	TCF7L2	-0.427227912765316
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/95	154/9376	0.640874914559125	JUN	-0.454614829539528
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/95	157/9376	0.628628897083473	TCF7L2	-0.474751210410249
NA	NA	hsa04517	IgSF CAM signaling	2/95	299/9376	0.660165463826791	PAK3/FOXO1	-0.604201770454123
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/95	163/9376	0.6054891830804	JUN	-0.514046298856752
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/95	168/9376	0.587468671679198	IL33	-0.545857114672523
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/95	169/9376	0.583992525692931	IRS2	-0.552122529249997
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/95	170/9376	0.580557275541796	JUN	-0.55835665338049
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	1/95	181/9376	0.545274789182902	HLA-DQA2	-0.624974802720102
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	1/95	217/9376	0.454814455493573	JUN	-0.822053767375933