category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	17/229	88/9376	7.90948789202064	C1QC/C1QB/SERPING1/CFD/C1QA/CD59/VSIG4/TFPI/PLAT/C1R/F2R/F3/C1S/PLAUR/SERPINE1/C5AR1/CD55	10.3036270993145
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	17/229	103/9376	6.75762072327977	CXCL3/HSPB1/IL1B/LAMB1/CD14/IL1R1/COL1A2/FN1/CXCL2/PIK3R1/LAMA4/COL4A1/COL4A2/VCL/CXCL1/IL6/COL1A1	9.29641654886676
NA	NA	hsa04518	Integrin signaling	19/229	154/9376	5.05143764532411	SPP1/FERMT2/LAMB1/FBN1/COL1A2/FN1/PIK3R1/COL6A3/LAMA4/COL4A1/PDGFRA/THBS1/PDGFRB/ITGB5/COL4A2/EGFR/VCL/TLN2/COL1A1	8.02086119050562
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	23/229	233/9376	4.04160653709916	DCN/VCAN/LMOD1/MYL9/TPM2/FBN1/COL1A2/TPM1/FBLN1/FN1/COL6A3/FBLN2/COL4A1/SDC2/THBS1/ITGB5/COL4A2/VCL/NID1/TLN2/SYNPO2/ANK2/COL1A1	7.43876216290228
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/229	101/9376	6.08067793678931	EGR1/JUN/MMP2/IL1B/COL1A2/FN1/PIK3R1/COL4A1/F3/FOXO1/COL4A2/SERPINE1/CYBB/IL6/COL1A1	8.12249464159067
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/229	203/9376	4.23550670079807	SPP1/JUN/LAMB1/MYL9/COL1A2/FN1/PIK3R1/COL6A3/LAMA4/COL4A1/PDGFRA/THBS1/PDGFRB/ITGB5/EMP1/COL4A2/EGFR/VCL/CAV1/TLN2/COL1A1	7.37392414301518
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	16/229	142/9376	4.61332185251246	FOS/JUNB/JUN/IL1B/NFKBIA/FOSB/IL1R1/TYROBP/PIK3R1/TREM2/SPI1/FCGR2A/FOSL2/IFNGR2/FCGR3A/JUND	6.86467410836991
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	12/229	78/9376	6.29895868323816	C1QC/C1QB/FOS/SERPING1/C1QA/JUN/IL1B/CD14/C1R/C1S/CFL2/IL6	7.43544736305355
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/229	109/9376	5.25876367132727	FOS/CCL3/SPP1/JUN/IL1B/NFKBIA/CD14/CCL3L1/CCL4/PIK3R1/CCL4L1/MAP3K8/CCL4L2/IL6	7.07605578424462
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/229	103/9376	5.16759231780218	C1QC/C1QB/FOS/CCL3/C1QA/JUN/IL1B/NFKBIA/CCL3L1/PIK3R1/SERPINE1/IFNGR2/IL6	6.72911191171276
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	18/229	204/9376	3.61263806832777	TIMP3/DCN/LUM/MMP2/CD63/COL1A2/FN1/PIK3R1/SDC2/MRAS/THBS1/PLAUR/ITGB5/EGFR/CAV1/ANK2/CTTN/COL1A1	5.96934048224694
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	11/229	78/9376	5.77404545963498	FOS/JUN/IL1B/HLA-DRA/NFKBIA/FCGR2A/CYBB/HLA-DQA2/MARCKSL1/IFNGR2/FCGR3A	6.69889422543083
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	12/229	94/9376	5.22679550311251	FOS/CXCL3/S100A8/JUN/IL1B/NFKBIA/FOSB/CXCL2/CXCL1/CEBPB/IL6/JUND	6.51656034502052
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	13/229	119/9376	4.47278998935819	FOS/CXCL3/JUNB/MMP14/JUN/IL1B/NFKBIA/CXCL2/PIK3R1/CXCL1/CEBPB/MAP3K8/IL6	6.03227191118756
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/229	89/9376	5.06039939159021	SPP1/LAMB1/COL1A2/FN1/COL6A3/LAMA4/COL4A1/THBS1/ITGB5/COL4A2/COL1A1	6.08961833773069
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	11/229	95/9376	4.74079521948977	FOS/CCL3/CXCL3/JUN/IL1B/HLA-DRA/CCL3L1/CXCL2/CXCL1/HLA-DQA2/IL6	5.79818930621457
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	11/229	99/9376	4.54924793789423	C1QC/C1QB/CFD/C1QA/HLA-DRA/C1R/C1S/FCGR2A/C5AR1/HLA-DQA2/FCGR3A	5.61712640988626
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/229	103/9376	4.37257811506338	COL15A1/COL1A2/MME/COL18A1/CPB1/COL6A3/SLC7A8/COL4A1/COL4A2/SLC8A1/COL1A1	5.44545959313576
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/229	142/9376	3.74832400516637	FOS/JUN/MMP2/IL1B/IL1R1/GSTP1/PLAT/PIK3R1/SDC2/GSTT1/CAV1/MGST1/NFE2L2	5.22133078916253
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	11/229	105/9376	4.2892909128717	CXCL3/IL1B/NFKBIA/GADD45B/CD14/IL1R1/CCL4/CXCL2/CCL4L1/CXCL1/CCL4L2	5.36287511964414
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	22/229	362/9376	2.48826268426259	SPP1/PRLR/LAMB1/COL1A2/FGF7/FN1/PIK3R1/COL6A3/LAMA4/COL4A1/F2R/NR4A1/PDGFRA/THBS1/PDGFRB/ITGB5/INSR/COL4A2/EGFR/PRL/IL6/COL1A1	4.569189192627
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/229	298/9376	2.61047448785206	CCL3/CXCL3/CXCL14/PRLR/IL1B/IL1R1/CCL3L1/CCL4/CXCL2/TNFRSF12A/CCL4L1/CXCL1/IL1RL1/CLCF1/GDF7/PRL/IFNGR2/CCL4L2/IL6	4.47024094403454
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	10/229	100/9376	4.0943231441048	CCL3/CXCL3/CXCL14/CCL3L1/CCL4/CXCL2/CCL4L1/CXCL1/CCL4L2/IL6	4.92208756356665
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	12/229	144/9376	3.41193595342067	C1QC/C1QB/CXCL3/C1QA/IL1B/NFKBIA/CD14/CXCL2/FOXO1/CXCL1/C5AR1/IL6	4.61490918706981
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	16/229	238/9376	2.75248614729735	C1QC/C1QB/FOS/CFD/C1QA/JUN/IL1B/NFKBIA/C1R/PIK3R1/C1S/FCGR2A/EGFR/CYBB/C5AR1/IL6	4.33292862629426
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/229	130/9376	3.46442727578099	FOS/JUN/MMP2/NFKBIA/COL1A2/PIK3R1/COL4A1/COL4A2/EGFR/ACTA2/COL1A1	4.47687303891415
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	7/229	56/9376	5.117903930131	CXCL3/IL1B/NFKBIA/CD14/CXCL2/CXCL1/IL6	4.89019646697511
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/229	42/9376	5.84903306300686	FTL/FTH1/SLC40A1/SAT1/GPX4/CYBB	4.98321852217978
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/229	100/9376	3.68489082969432	CD59/IL1B/HLA-DRA/CD14/IL1R1/MME/HLA-DQA2/CD55/IL6	4.27081049616613
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	14/229	216/9376	2.65372796377163	FOS/CCL3/CXCL3/JUN/IL1B/NFKBIA/CD14/CCL3L1/CXCL2/PIK3R1/CXCL1/CYBB/NFE2L2/IL6	3.89051638547371
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/229	106/9376	3.47631210348521	NFKBIA/FOLR2/GSTP1/PLAT/PIK3R1/PDGFRA/FOXO1/PDGFRB/EGFR	4.05678961465623
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	13/229	201/9376	2.64806969519216	IGFBP3/NUPR1/GADD45B/CD14/HOXA10/PLAT/WT1/NFKBIZ/PBX1/FOXO1/SPI1/CEBPB/IL6	3.73709902358323
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/229	50/9376	4.91318777292576	IL1B/LRP1/SDC2/THBS1/CD81/IL6	4.38967153201216
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/229	109/9376	3.38063378871039	FOS/JUN/IL1B/HLA-DRA/NFKBIA/IL1R1/HLA-DQA2/IFNGR2/IL6	3.95549008839984
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	11/229	155/9376	2.90564868291309	HLA-DRA/CD14/TUBA1A/C1R/THBS1/ITGB5/FCGR2A/CYBB/CANX/HLA-DQA2/FCGR3A	3.78515542380733
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	6/229	52/9376	4.72421901242862	APOE/APOC1/LRP1/PLTP/LRPAP1/NPC2	4.26088479613314
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	12/229	181/9376	2.71446838283191	IL1B/CD74/HLA-DRA/FCER1G/CD14/FCGR2A/HLA-DQA2/CEBPB/IFNGR2/FCGR3A/CARD9/IL6	3.68516502738646
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	11/229	157/9376	2.86863405000973	C1QC/C1QB/C1QA/MFGE8/LRP1/BSG/PBX1/THBS1/ITGB5/AXL/CEBPB	3.73590837830449
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/229	232/9376	2.47071224213221	GSN/MYL9/FGF7/FN1/PIK3R1/F2R/MRAS/PDGFRA/PDGFRB/ITGB5/EGFR/VCL/ENAH/CFL2	3.58895184385814
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/229	93/9376	3.52199840353101	NFKBIA/GADD45B/LAMB1/FN1/PIK3R1/LAMA4/COL4A1/COL4A2	3.86728471118314
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	16/229	300/9376	2.18363901018923	FOS/HSPB1/JUN/IL1B/GADD45B/CD14/IL1R1/FGF7/MRAS/NR4A1/PDGFRA/PDGFRB/INSR/EGFR/MAP3K8/JUND	3.29683106468784
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/229	224/9376	2.37616968184654	FOS/EGR1/JUN/HLA-DRA/NFKBIA/IL1R1/PIK3R1/ZFP36/SPI1/CANX/HLA-DQA2/TLN2/IL6	3.29839018159911
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	14/229	253/9376	2.2656333603742	JUN/IL1B/NFKBIA/MYL9/CD14/IL1R1/PIK3R1/FOXO1/EGFR/VCL/UBB/UBC/TLN2/CTTN	3.22896529102569
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/229	82/9376	3.4951539035041	CTSB/CD74/HLA-DRA/IFI30/LGMN/CANX/HLA-DQA2	3.59059953607855
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/229	83/9376	3.45304361551008	IL1B/NFKBIA/CCL4/CCL4L1/POLR2L/CCL4L2/IL6	3.55165184985699
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/229	105/9376	3.11948430027033	JUN/IL1B/NFKBIA/FCER1G/PIK3R1/MRAS/CARD9/IL6	3.45561700727547
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/229	66/9376	3.72211194918619	JUN/IL1B/HLA-DRA/HLA-DQA2/IFNGR2/IL6	3.51129363366663
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	8/229	110/9376	2.97768955934895	TIMP1/PIK3R1/INSR/EGFR/SERPINE1/CYBB/IFNGR2/IL6	3.30120394389051
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	11/229	187/9376	2.40842537888518	CXCL3/CTSB/JUN/IL1B/NFKBIA/CXCL2/ANTXR1/CXCL1/CYBB/CARD9/IL6	3.07811300290921
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/229	71/9376	3.45999138938434	CXCL3/JUN/NFKBIA/CXCL2/EGFR/CXCL1	3.29206659857033
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	11/229	193/9376	2.33355205104419	CCL3/CXCL3/CXCL14/NFKBIA/CCL3L1/CCL4/CXCL2/PIK3R1/CCL4L1/CXCL1/CCL4L2	2.96183167861896
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/229	143/9376	2.57684673405197	C1QC/C1QB/C1QA/HLA-DRA/C1R/C1S/FCGR2A/HLA-DQA2/FCGR3A	3.00642326629888
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	11/229	196/9376	2.29783441760984	FOS/CXCL3/JUN/NFKBIA/CXCL2/PIK3R1/ZFP36/CXCL1/UBB/UBC/IL6	2.9052935641817
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/229	73/9376	3.36519710474367	GADD45B/FGF7/PIK3R1/PDGFRA/PDGFRB/EGFR	3.20982457756699
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	12/229	227/9376	2.1643998999673	CCL3/IL1B/NFKBIA/IL1R1/CCL3L1/CCL4/PIK3R1/PDGFRA/CCL4L1/EGFR/CCL4L2/IL6	2.80990938009542
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	7/229	98/9376	2.92451653150343	GSN/PIK3R1/FCGR2A/MARCKS/MARCKSL1/CFL2/FCGR3A	3.03020171459074
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/229	37/9376	4.42629529092411	IL1B/LAMA4/IL6/APOL1	3.30399592890408
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/229	180/9376	2.27462396894711	IL1B/CD74/HLA-DRA/NFKBIA/PIK3R1/PILRA/HLA-DQA2/IFNGR2/CARD9/IL6	2.73201382110917
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	6/229	80/9376	3.0707423580786	PIK3R1/PDGFRA/PDGFRB/EGFR/AXL/IL6	2.9429781865209
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/229	59/9376	3.46976537636	GSTP1/GPX3/GPX4/GSTT1/MGST1	3.01097878726801
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	11/229	212/9376	2.12441295212985	FGF7/PIK3R1/F2R/MRAS/PDGFRA/THBS1/PDGFRB/INSR/EGFR/ENAH/TLN2	2.62008432940103
Organismal Systems	Digestive system	hsa04978	Mineral absorption	5/229	61/9376	3.35600257713508	FTL/FTH1/SLC40A1/CYBRD1/SLC8A1	2.92087713416761
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	15/229	333/9376	1.84428970455171	SPP1/LAMB1/COL1A2/FN1/PIK3R1/COL6A3/LAMA4/COL4A1/FOXO1/THBS1/PDGFRB/ITGB5/COL4A2/EGFR/COL1A1	2.4821120592717
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	5/229	62/9376	3.30187350331033	CRYAB/IRS2/PIK3R1/FOXO1/INSR	2.87722100110748
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	8/229	138/9376	2.37352066324916	FOS/JUN/IL1B/NFKBIA/FN1/PIK3R1/FCGR2A/IL6	2.57187467141151
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	9/229	168/9376	2.19338739862757	PRLR/PIK3R1/PDGFRA/PDGFRB/EGFR/CLCF1/PRL/IFNGR2/IL6	2.46954800680866
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/229	90/9376	2.72954876273654	FOS/JUN/NFKBIA/PIK3R1/EGFR/IFNGR2	2.6085776313214
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/229	45/9376	3.63939835031538	IL1B/HLA-DRA/HLA-DQA2/IL6	2.80809077582544
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	10/229	200/9376	2.0471615720524	FOS/JUN/IL1B/NFKBIA/IL1R1/TUBA1A/F2R/FCGR2A/CTTN/IL6	2.36845987533307
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	6/229	93/9376	2.64149880264826	FOS/JUN/HLA-DRA/NFKBIA/HLA-DQA2/IFNGR2	2.51710834313737
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	8/229	149/9376	2.19829430555963	FCER1G/PIK3R1/F2R/MRAS/PDGFRA/PDGFRB/INSR/EGFR	2.33286930692053
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/229	99/9376	2.48140796612412	FOS/JUN/PIK3R1/PDGFRA/PDGFRB/EGFR	2.34451240261021
Organismal Systems	Immune system	hsa04611	Platelet activation	7/229	126/9376	2.27462396894711	FCER1G/COL1A2/PIK3R1/F2R/FCGR2A/TLN2/COL1A1	2.27908502223859
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/229	30/9376	4.0943231441048	IL1B/FOLR2/IL6	2.68582334583066
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/229	75/9376	2.72954876273654	IGFBP3/GADD45B/THBS1/CD82/SERPINE1	2.37937371884927
Human Diseases	Cancer: specific types	hsa05214	Glioma	5/229	76/9376	2.69363364743737	GADD45B/PIK3R1/PDGFRA/PDGFRB/EGFR	2.34557235791628
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/229	78/9376	2.6245661180159	FN1/PIK3R1/VCL/CAV1/CTTN	2.27957539969454
Human Diseases	Immune disease	hsa05310	Asthma	3/229	32/9376	3.83842794759825	HLA-DRA/FCER1G/HLA-DQA2	2.54478143859359
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	7/229	133/9376	2.1549069179499	GADD45B/IRS2/PIK3R1/FOXO1/INSR/EGFR/IL6	2.12241529451932
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	6/229	109/9376	2.25375585914026	NFKBIA/IRS2/PIK3R1/FOXO1/INSR/IL6	2.08315067089297
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/229	137/9376	2.09198992764479	FOS/CTSB/JUN/NFKBIA/GADD45B/TUBA1A/PIK3R1	2.03718501223272
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/229	110/9376	2.23326716951171	DCN/FBN1/ID4/LTBP1/THBS1/GDF7	2.0585973286945
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/229	140/9376	2.0471615720524	EGR1/SPP1/PLAT/MRAS/SERPINE1/ACTA2/SLC8A1	1.97514867593634
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/229	59/9376	2.775812301088	IRS2/PIK3R1/INSR/NPR1	2.16495591845489
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/229	112/9376	2.19338739862757	HLA-DRA/NFKBIA/LAMB1/LAMA4/HLA-DQA2/IFNGR2	2.01027386079188
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/229	87/9376	2.35305927822115	FOS/JUN/GADD45B/PIK3R1/EGFR	2.00611584608051
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	6/229	115/9376	2.13616859692425	FOS/EGR1/MMP14/NR4A2/EGFR/JUND	1.93966531283918
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/229	116/9376	2.11775335039904	MMP2/MYL9/THY1/PIK3R1/VCL/CYBB	1.91660899223034
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/229	89/9376	2.30018154163191	TUBA1A/PDGFRA/PDGFRB/EGFR/GJA1	1.94995826634675
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	5/229	91/9376	2.24962810115649	FOS/JUN/NFKBIA/PIK3R1/CD81	1.89528517190357
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/229	93/9376	2.20124900220688	MYL9/INSR/SNAI2/EGFR/VCL	1.84202015911449
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	5/229	93/9376	2.20124900220688	EGR1/MMP14/JUN/MMP2/EGFR	1.84202015911449
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/229	41/9376	2.99584620300351	MMP2/THBS1/EGFR	2.02640327738909
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	8/229	184/9376	1.78014049743687	MYL9/PIK3R1/SEMA5A/TRPC6/GDF7/ENAH/CFL2/SRGAP1	1.69098893733159
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/229	157/9376	1.82549439546074	IGFBP3/GADD45B/PIK3R1/MRAS/FOXO1/SERPINE1/IL6	1.65038811544139
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/229	157/9376	1.82549439546074	FOS/JUN/IL1B/IRS2/PIK3R1/INSR/IL6	1.65038811544139
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/229	70/9376	2.33961322520274	HLA-DRA/HLA-DQA2/CAV1/CD55	1.77996294839889
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/229	44/9376	2.79158396188964	IL1B/HLA-DRA/HLA-DQA2	1.88469109705756
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/229	99/9376	2.0678399717701	FOS/JUN/MMP2/PIK3R1/EGFR	1.68998960115499
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/229	99/9376	2.0678399717701	TPM2/TPM1/ITGB5/SLC8A1/IL6	1.68998960115499
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/229	71/9376	2.30666092625623	FOS/PRLR/PIK3R1/PRL	1.74863001941712
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/229	71/9376	2.30666092625623	PIK3R1/PDGFRA/PDGFRB/EGFR	1.74863001941712
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/229	47/9376	2.61339775155626	IRS2/PIK3R1/INSR	1.75443333134665
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/229	134/9376	1.83327901974842	CALD1/RAMP1/MYL9/NPR1/ACTA2/PPP1R14A	1.53717709389249
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/229	75/9376	2.18363901018923	GSTP1/PIK3R1/GSTT1/MGST1	1.62835510286103
NA	NA	hsa03272	Virion - Hepatitis viruses	3/229	48/9376	2.5589519650655	CD63/EGFR/CD81	1.71325940108882
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/229	166/9376	1.72652180775504	MYL9/IRS2/RGS2/INSR/TRPC6/NPR1/SLC8A1	1.49429699689507
NA	NA	hsa04517	IgSF CAM signaling	11/229	299/9376	1.50627272860043	MYL9/TUBA1A/PIK3R1/FOXO1/CLMP/TRPC6/VCL/CRTAM/PMP22/ANK2/SRGAP1	1.4077093659944
Human Diseases	Infectious disease: viral	hsa05162	Measles	6/229	136/9376	1.80631903416388	FOS/JUN/IL1B/NFKBIA/PIK3R1/IL6	1.49866450143453
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/229	50/9376	2.45659388646288	HLA-DRA/HLA-DQA2/IL6	1.63395397515732
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	7/229	170/9376	1.68589776521962	GADD45B/GSTP1/PIK3R1/EGFR/GSTT1/MGST1/NFE2L2	1.42794803478736
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/229	173/9376	1.65666254385743	IL1B/HLA-DRA/NFKBIA/PIK3R1/HLA-DQA2/IFNGR2/IL6	1.3793187031186
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	7/229	174/9376	1.64714149475481	CRYAB/P4HB/RRBP1/PPP1R15A/DNAJA1/CANX/NFE2L2	1.36331683360046
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	10/229	275/9376	1.48884477967447	C1QC/C1QB/EGR1/C1QA/IL1B/TUBA1A/PIK3R1/CYBB/CAV1/IL6	1.30183760157958
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	9/229	248/9376	1.48584307648965	FOS/JUN/IL1B/NFKBIA/MYL9/CD14/RHOB/TUBA1A/IL6	1.22686868839294
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	6/229	148/9376	1.65986073409654	FOS/JUN/GADD45B/FGF7/PIK3R1/EGFR	1.28024589049517
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	13/229	388/9376	1.37180930085986	APOE/DKK1/IL1B/MME/IRS2/TUBA1A/PIK3R1/LRP1/BACE1/INSR/CYBB/SLC39A6/IL6	1.18350097556947
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	8/229	217/9376	1.50942788722758	FOS/JUN/FGF7/PIK3R1/KLF4/EGFR/GSTT1/MGST1	1.20130308614498
NA	NA	hsa04081	Hormone signaling	8/229	219/9376	1.49564315766385	RAMP1/PRLR/SLC40A1/IRS2/PIK3R1/INSR/NPR1/PRL	1.17429876811461
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	3/229	59/9376	2.081859225816	GADD45B/PIK3R1/EGFR	1.31893304964178
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/229	154/9376	1.59519083536551	FOS/JUN/MYL9/RGS2/EGFR/NPR1	1.17833309808867
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/229	90/9376	1.81969917515769	IRS2/PIK3R1/FOXO1/INSR	1.23630450831913
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/229	122/9376	1.67800128856754	IRS2/PIK3R1/CAB39L/FOXO1/INSR	1.19264097700058
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/229	122/9376	1.67800128856754	FOS/JUN/NFKBIA/PIK3R1/MAP3K8	1.19264097700058
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	5/229	122/9376	1.67800128856754	IGFBP3/FOS/JUNB/IRS2/PIK3R1	1.19264097700058
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	5/229	125/9376	1.63772925764192	FCER1G/S1PR3/PIK3R1/SPTSSA/CERS6	1.13569325844969
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/229	227/9376	1.44293326664486	FOS/JUN/NFKBIA/PIK3R1/EGFR/GSTT1/MGST1/NFE2L2	1.06887877673011
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/229	133/9376	1.53921922710707	FCER1G/TYROBP/PIK3R1/IFNGR2/FCGR3A	0.990943180721842
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/229	68/9376	1.80631903416388	CD14/PIK3R1/SPI1	1.05583783587202
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/229	169/9376	1.45360584997804	CTSB/IRS2/PIK3R1/MRAS/UBB/UBC	0.941514401478684
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/229	205/9376	1.39806156140164	JUN/HLA-DRA/NFKBIA/GADD45B/PIK3R1/HLA-DQA2/IL6	0.911764892811094
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/229	38/9376	2.1549069179499	PIK3R1/INSR	1.12869314169329
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/229	69/9376	1.78014049743687	FOS/JUN/FOSB	1.02909756629883
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/229	70/9376	1.75470991890206	GSTP1/GSTT1/MGST1	1.00279369235959
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/229	39/9376	2.09965289441272	HLA-DRA/HLA-DQA2	1.08880043476868
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	5/229	138/9376	1.48345041453073	IRS2/PIK3R1/RHOQ/FOXO1/INSR	0.905245846883496
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/229	139/9376	1.47277810939022	FOS/JUN/MMP2/PIK3R1/EGFR	0.888512061581766
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/229	105/9376	1.55974215013516	JUN/MRAS/UBB/UBC	0.912606190783914
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	4/229	105/9376	1.55974215013516	TPM2/TPM1/ITGB5/SLC8A1	0.912606190783914
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/229	73/9376	1.68259855237184	GSTP1/GSTT1/MGST1	0.926358993768607
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/229	73/9376	1.68259855237184	ELL2/MAP1B/MAP1A	0.926358993768607
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/229	73/9376	1.68259855237184	GADD45B/PIK3R1/EGFR	0.926358993768607
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	10/229	323/9376	1.26759230467641	TIMP3/TPM1/IRS2/PIK3R1/SOX4/PDGFRA/THBS1/PDGFRB/MARCKS/EGFR	0.774359553606429
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	3/229	77/9376	1.59519083536551	GADD45B/PIK3R1/EGFR	0.829750483150995
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/229	77/9376	1.59519083536551	NFKBIA/GADD45B/PIK3R1	0.829750483150995
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/229	14/9376	2.92451653150343	B3GNT7	1.14015890948362
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/229	79/9376	1.55480625725499	GSTP1/GSTT1/MGST1	0.783515370346388
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/229	46/9376	1.78014049743687	FTL/FTH1	0.839218321607824
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	7/229	226/9376	1.26815318622715	FOS/JUN/NFKBIA/MYL9/PIK3R1/F2R/NPR1	0.645640364515295
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/229	82/9376	1.49792310150176	GSTP1/GSTT1/MGST1	0.716525924410603
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/229	49/9376	1.67115230371625	JUN/FOSB	0.745267489673025
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/229	50/9376	1.63772925764192	SAT1/CKB	0.715381456205704
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	3/229	86/9376	1.42825225957144	JUN/PIK3R1/EGFR	0.63125534953967
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/229	86/9376	1.42825225957144	ITGB5/SLC8A1/GJA1	0.63125534953967
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	5/229	160/9376	1.27947598253275	VCAN/HLA-DRA/SDC2/NRXN2/HLA-DQA2	0.564153503788814
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/229	87/9376	1.41183556693269	TPM2/TPM1/SLC8A1	0.610608766446215
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/229	238/9376	1.20421268944259	FGF7/PIK3R1/MRAS/PDGFRA/PDGFRB/INSR/EGFR	0.504904994143844
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/229	163/9376	1.25592734481742	FOS/JUN/NFKBIA/PIK3R1/IL6	0.521523637871285
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/229	54/9376	1.51641597929808	HLA-DRA/HLA-DQA2	0.60215187426458
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	6/229	205/9376	1.19833848120141	MMP2/COL1A2/PIK3R1/INSR/CYBB/COL1A1	0.454296725903788
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/229	55/9376	1.48884477967447	PSAP/CERS6	0.575287731393068
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/229	168/9376	1.2185485547931	FTL/FTH1/IL1B/CYBB/IFNGR2	0.452255611631974
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	5/229	170/9376	1.20421268944259	JUN/MYL9/TUBA1A/RAB13/CTTN	0.425143692478447
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/229	250/9376	1.14641048034935	CTSB/PSAP/CD63/CD68/LGMN/LITAF/NPC2	0.37124958549569
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	7/229	250/9376	1.14641048034935	RAB31/DAB2/FOLR2/PDGFRA/EGFR/PSD3/CAV1	0.37124958549569
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/229	98/9376	1.25336422778718	NR4A2/NR4A1/NPR1	0.398928616558531
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/229	60/9376	1.36477438136827	HSPB1/PIK3R1	0.448486375987919
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/229	23/9376	1.78014049743687	PCYOX1	0.592686879962521
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/229	23/9376	1.78014049743687	MME	0.592686879962521
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/229	99/9376	1.24070398306206	IL1B/IL1R1/PIK3R1	0.38094399824457
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/229	144/9376	1.13731198447356	TBX3/ID4/PIK3R1/KLF4	0.262727680535256
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/229	65/9376	1.25979173664763	NR4A1/PBX1	0.332543059348527
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/229	65/9376	1.25979173664763	SPP1/PIK3R1	0.332543059348527
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/229	150/9376	1.09181950509461	GADD45B/FGF7/PIK3R1/EGFR	0.179365078450894
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/229	69/9376	1.18676033162458	FCER1G/PIK3R1	0.246358961478692
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/229	69/9376	1.18676033162458	CTSB/NPR1	0.246358961478692
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/229	29/9376	1.41183556693269	RASSF4	0.351439658189682
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/229	70/9376	1.16980661260137	NFKBIA/IRS2	0.225624436320284
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/229	70/9376	1.16980661260137	JUN/PIK3R1	0.225624436320284
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/229	194/9376	1.05523792373835	MYL9/TPM2/TPM1/TUBA1A/ACTA2	0.12300807063404
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	5/229	195/9376	1.04982644720636	PIK3R1/FCGR2A/CYBB/C5AR1/FCGR3A	0.111249040361239
NA	NA	hsa04519	Cadherin signaling	10/229	404/9376	1.01344632279822	NFKBIA/CDH11/MRAS/PDGFRA/PDGFRB/EGFR/VCL/LIMA1/ENAH/GJA1	0.043713302958141
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	4/229	156/9376	1.04982644720636	NFKBIA/PIK3R1/EGFR/CD81	0.0992934955795517
NA	NA	hsa04981	Folate transport and metabolism	1/229	31/9376	1.32074940132413	FOLR2	0.283022581762173
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/229	75/9376	1.09181950509461	GPX3/CANX	0.126317870884541
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/229	76/9376	1.07745345897495	PLTP/UBC	0.107267998998207
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/229	120/9376	1.0235807860262	JUN/NFKBIA/PIK3R1	0.0411340306527956
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/229	34/9376	1.20421268944259	POLR2L	0.188741017420457
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/229	34/9376	1.20421268944259	RORB	0.188741017420457
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/229	254/9376	0.967162947426332	FGF7/F2R/PDGFRA/PDGFRB/EGFR/SLC8A1	-0.0839460049286814
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/229	37/9376	1.10657382273103	GADD45B	0.102769740064083
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	5/229	214/9376	0.956617557033833	FOS/JUN/NFKBIA/PIK3R1/CFL2	-0.101575691432517
NA	NA	hsa04382	Cornified envelope formation	5/229	217/9376	0.943392429517236	S100A8/COL4A1/COL4A2/DST/S100A16	-0.133488666060669
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/229	48/9376	0.852983988355167	PIK3R1	-0.161567880027984
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/229	51/9376	0.802808459628393	PLD3	-0.223415339028396
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/229	51/9376	0.802808459628393	KDELR2	-0.223415339028396
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/229	52/9376	0.78736983540477	INSR	-0.243270503829014
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/229	154/9376	0.797595417682754	TPM2/TPM1/SLC8A1	-0.400711846315242
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/229	53/9376	0.772513800774491	SLC8A1	-0.26277206090236
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/229	155/9376	0.792449640794478	NR4A1/PBX1/EGFR	-0.412253514986304
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/229	107/9376	0.765294045627066	FOXO1/SIK1	-0.386334591108986
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/229	205/9376	0.798892320800937	GSN/JUN/NFKBIA/PIK3R1	-0.460639607910822
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/229	157/9376	0.782354740911746	SNAI2/SERPINE1/GDF7	-0.435132147421708
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/229	158/9376	0.777403128627494	PIK3R1/CAB39L/INSR	-0.446471033241846
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/229	56/9376	0.731129132875858	GAS1	-0.319296269847943
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	2/229	115/9376	0.712056198974748	FOS/PIK3R1	-0.491577222260603
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/229	268/9376	0.763866258228508	TUBA1A/UBB/UBC/SLC39A6/NFE2L2	-0.62055170737638
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/229	63/9376	0.649892562556318	GPX4	-0.441154638337018
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/229	63/9376	0.649892562556318	POLR2L	-0.441154638337018
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/229	63/9376	0.649892562556318	GADD45B	-0.441154638337018
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	2/229	122/9376	0.671200515427017	PIK3R1/FOXO1	-0.578376096226764
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	3/229	178/9376	0.690054462489574	DKK1/JUN/SERPINF1	-0.660560691573414
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/229	72/9376	0.568655992236778	NFKBIA	-0.581325275866053
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/229	78/9376	0.52491322360318	BTG2	-0.666637150796327
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/229	142/9376	0.576665231564057	UBB/UBC	-0.804261381264534
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/229	370/9376	0.663944293638617	PRLR/S1PR3/F2R/P2RY14/C5AR1/PRL	-1.0435426531022
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/229	93/9376	0.440249800441377	CST3	-0.858332576977047
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	2/229	158/9376	0.518268752418329	GADD45B/CDKN1C	-0.966226733226394
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	8/229	480/9376	0.682387190684134	DKK1/IL1B/GPX3/TUBA1A/UBB/UBC/CYBB/IL6	-1.1302780159196
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/229	97/9376	0.422095169495341	FOS	-0.905223133761873
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/229	98/9376	0.417788075929062	PIK3R1	-0.916707932457573
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/229	102/9376	0.401404229814196	CPB1	-0.961754492458064
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	1/229	104/9376	0.393684917702385	PLD3	-0.983767270306707
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	1/229	110/9376	0.372211194918618	PIK3R1	-1.04791920929553
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/229	117/9376	0.349942149068787	MORF4L2	-1.11950731692614
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	4/229	308/9376	0.531730278455169	TGM2/GPX3/TUBA1A/POLR2L	-1.32214692548936
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/229	128/9376	0.319868995633188	NPR1	-1.22585100404427
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/229	133/9376	0.307843845421414	FOS	-1.27200104687311
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/229	144/9376	0.284327996118389	PIK3R1	-1.3693403844152
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/229	235/9376	0.348453033540834	NPR1/ZNF516	-1.60046744119989
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/229	183/9376	0.223733505142339	SBDS	-1.67792210781611
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/229	191/9376	0.214362468277738	FOSB	-1.73565484780066
NA	NA	hsa04082	Neuroactive ligand signaling	1/229	199/9376	0.205744881613307	P2RY14	-1.7918441551335
Genetic Information Processing	Translation	hsa03010	Ribosome	1/229	222/9376	0.184428970455171	MT-RNR2	-1.94579401629465
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	2/229	368/9376	0.222517562179609	GPX3/TUBA1A	-2.4074892032934
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/229	449/9376	0.182375195728499	RGS2/SLC8A1	-2.80923778472319