category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/106	95/9376	8.37974180734856	JUN/FOS/CXCL3/HLA-DQA2/CCL3/HLA-DRA/IL1B/CXCL2/CXCL1	7.7304413155521
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/106	78/9376	9.07208514755685	C1QC/JUN/C1QB/FOS/C1QA/IL1B/SERPING1/CD14	7.65485499890106
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/106	105/9376	7.58167115902965	CXCL3/NFKBIA/IL1B/IL1R1/CCL4/CXCL2/CXCL1/CD14/CCL4L1	7.25214105426114
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	9/106	109/9376	7.3034446944781	JUN/SPP1/FOS/NFKBIA/CCL3/IL1B/CCL4/CD14/CCL4L1	7.0781590618881
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/106	119/9376	6.68970984620263	JUN/FOS/CXCL3/MMP14/NFKBIA/IL1B/CXCL2/CXCL1/JUNB	6.67924189554975
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	8/106	94/9376	7.52790044158972	JUN/S100A8/FOS/CXCL3/NFKBIA/IL1B/CXCL2/CXCL1	6.80166708023327
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/106	103/9376	6.8701227331013	C1QC/JUN/C1QB/FOS/C1QA/NFKBIA/CCL3/IL1B	6.40551965051758
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	11/106	216/9376	4.50454227812718	JUN/FOS/CXCL3/NFKBIA/CCL3/IL1B/CXCL2/CXCL1/OLR1/ABCA1/CD14	5.57197483203162
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/106	144/9376	5.52830188679245	C1QC/C1QB/CXCL3/C1QA/NFKBIA/IL1B/CXCL2/CXCL1/CD14	5.85554636344269
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	6/106	56/9376	9.47708894878706	CXCL3/NFKBIA/IL1B/CXCL2/CXCL1/CD14	6.80348609094885
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/106	88/9376	7.03602058319039	C1QC/CFD/C1QB/VSIG4/PLAUR/C1QA/SERPING1	6.0831657298099
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	7/106	100/9376	6.19169811320755	CXCL14/CXCL3/CCL3/CCL4/CXCL2/CXCL1/CCL4L1	5.58120230543513
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/106	103/9376	6.01135739146364	CXCL3/IL1B/IL1R1/FN1/CXCL2/CXCL1/CD14	5.46842880571725
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	7/106	109/9376	5.68045698459408	JUN/FOS/NFKBIA/HLA-DQA2/HLA-DRA/IL1B/IL1R1	5.25570075173397
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/106	78/9376	6.80406386066764	JUN/FOS/NFKBIA/HLA-DQA2/HLA-DRA/IL1B	5.50406325572766
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	9/106	187/9376	4.25708808394713	JUN/CXCL3/CTSB/ANTXR1/NFKBIA/IL1B/CXCL2/CXCL1/YWHAE	4.81077322243808
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/106	82/9376	6.47215830648872	IFI30/CTSB/HLA-DQA2/HLA-DRA/CD74/LGMN	5.32185391113972
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/106	298/9376	3.26503735595796	CXCL14/CXCL3/CCL3/IL1B/IL1R1/PRLR/TNFRSF12A/CCL4/CXCL2/CXCL1/CCL4L1	4.24900376165358
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/106	99/9376	5.36077758719268	C1QC/CFD/C1QB/C1QA/HLA-DQA2/HLA-DRA	4.66419242910576
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/106	137/9376	4.51948767387412	JUN/FOS/CTSB/NFKBIA/GZMB/CTSH/CTSZ	4.4373731616204
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	7/106	142/9376	4.36035078394898	JUN/FOS/NFKBIA/IL1B/IL1R1/JUNB/FOSL2	4.31452069242163
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/106	71/9376	6.22907254849854	JUN/CXCL3/NFKBIA/CXCL2/CXCL1	4.72927269564312
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/106	42/9376	8.4240790655885	FTL/FTH1/SLC40A1/SAT1	5.15622712386798
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	9/106	233/9376	3.41663292574298	DCN/VCAN/LMOD1/TPM1/FBN1/FN1/ITGB8/TLN1/SYNPO2	3.99432126728235
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	9/106	238/9376	3.34485492310132	C1QC/JUN/CFD/C1QB/FOS/C1QA/NFKBIA/IL1B/RPL12	3.91811865039576
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/106	44/9376	8.04116638078902	HLA-DQA2/HLA-DRA/IL1B/GZMB	5.00590131324098
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/106	193/9376	3.6664385570437	CXCL14/CXCL3/NFKBIA/CCL3/CCL4/CXCL2/CXCL1/CCL4L1	4.00236458249276
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/106	45/9376	7.86247379454927	HLA-DQA2/HLA-DRA/IL1B/GZMB	4.93425471712009
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	4/106	52/9376	6.80406386066764	APOC1/APOE/ABCA1/PLTP	4.48777862149056
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	8/106	224/9376	3.15902964959569	JUN/EGR1/FOS/NFKBIA/HLA-DQA2/HLA-DRA/IL1R1/TLN1	3.49722290131238
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/106	93/9376	4.7555285047677	JUN/FOS/NFKBIA/HLA-DQA2/HLA-DRA	3.89194832626915
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/106	142/9376	3.73744352909912	JUN/FOS/MMP2/GSTP1/IL1B/IL1R1	3.51473923706091
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/106	100/9376	4.42264150943396	HLA-DQA2/HLA-DRA/IL1B/IL1R1/CD14	3.67942323813757
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/106	101/9376	4.37885297963759	JUN/EGR1/MMP2/IL1B/FN1	3.65066285290589
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/106	66/9376	5.36077758719268	JUN/HLA-DQA2/HLA-DRA/IL1B	3.80154178073824
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/106	201/9376	3.08044682249132	IGFBP3/GZMB/NUPR1/PBX1/NFKBIZ/CD14/KLF3	3.18823492913689
NA	NA	hsa04518	Integrin signaling	6/106	154/9376	3.4462141631953	SPP1/FBN1/FERMT2/FN1/ITGB8/TLN1	3.27296213956385
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/106	39/9376	6.80406386066764	HLA-DQA2/HLA-DRA/GZMB	3.88382372253268
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	4/106	83/9376	4.26278699704478	NFKBIA/IL1B/CCL4/CCL4L1	3.19262936787097
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/106	180/9376	2.94842767295597	NFKBIA/HLA-DQA2/PILRA/HLA-DRA/IL1B/CD74	2.82240780290577
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	5/106	138/9376	3.20481268799562	JUN/FOS/NFKBIA/IL1B/FN1	2.79010769881585
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/106	93/9376	3.80442280381416	JUN/EGR1/MMP14/MMP2	2.906293647778
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/106	143/9376	3.09275630030347	C1QC/C1QB/C1QA/HLA-DQA2/HLA-DRA	2.69658405859121
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/106	54/9376	4.91404612159329	HLA-DQA2/HLA-DRA/GZMB	3.08437357201137
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/106	250/9376	2.47667924528302	CTSB/LITAF/CD68/PSAP/LGMN/CTSH/CTSZ	2.5305483920084
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/106	196/9376	2.70773969965345	JUN/FOS/CXCL3/NFKBIA/CXCL2/CXCL1	2.58361069330517
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/106	204/9376	2.6015538290788	TIMP3/DCN/LUM/PLAUR/MMP2/FN1	2.47299537736107
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/106	61/9376	4.35013918960718	FTL/FTH1/SLC40A1	2.80695236700294
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/106	157/9376	2.81696911428915	C1QC/C1QB/C1QA/PBX1/ABCA1	2.45501509904161
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	5/106	160/9376	2.76415094339623	VCAN/HLA-DQA2/HLA-DRA/ITGB8/NLGN4X	2.40670690129618
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/106	115/9376	3.0766201804758	EGR1/FOS/MMP14/NR4A2	2.39593897325734
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/106	227/9376	2.3379602693043	NFKBIA/CCL3/IL1B/IL1R1/CCL4/CCL4L1	2.18206677100308
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/106	30/9376	5.89685534591195	IL1B/FOLR2	2.87252434342506
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/106	122/9376	2.90009279307145	IGFBP3/FOS/JUNB/IRS2	2.25885670890343
Human Diseases	Immune disease	hsa05310	Asthma	2/106	32/9376	5.52830188679245	HLA-DQA2/HLA-DRA	2.74373807571523
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	5/106	181/9376	2.44344834775357	HLA-DQA2/HLA-DRA/IL1B/CD74/CD14	2.09683072698143
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	4/106	130/9376	2.72162554426705	JUN/FOS/MMP2/NFKBIA	2.11364542123239
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	6/106	248/9376	2.13998782714547	JUN/FOS/RHOB/NFKBIA/IL1B/CD14	1.94552556690036
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	6/106	253/9376	2.09769557759714	JUN/NFKBIA/IL1B/IL1R1/TLN1/CD14	1.89265754955561
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/106	136/9376	2.6015538290788	JUN/FOS/NFKBIA/IL1B	2.01174862168412
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/106	200/9376	2.21132075471698	JUN/FOS/NFKBIA/IL1B/IL1R1	1.8515956747297
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/106	89/9376	2.9815560737757	SPP1/FN1/ITGB8	2.00845613334186
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/106	203/9376	2.1786411376522	JUN/SPP1/FN1/ITGB8/TLN1	1.81540121176548
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/106	90/9376	2.94842767295597	JUN/FOS/NFKBIA	1.98604876526004
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/106	91/9376	2.91602736885756	JUN/FOS/NFKBIA	1.96394876667856
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/106	46/9376	3.84577522559475	FTL/FTH1	2.06888995952886
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/106	155/9376	2.2826536822885	HLA-DQA2/HLA-DRA/OLR1/CD14	1.72180892285885
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/106	99/9376	2.68038879359634	JUN/FOS/MMP2	1.79730713899854
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/106	157/9376	2.25357529143132	JUN/FOS/IL1B/IRS2	1.69378017713493
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/106	50/9376	3.53811320754717	SAT1/AOC1	1.92418572941652
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/106	50/9376	3.53811320754717	HLA-DQA2/HLA-DRA	1.92418572941652
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/106	105/9376	2.52722371967655	JUN/NFKBIA/IL1B	1.68280085238118
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	3/106	106/9376	2.50338198647205	NFKBIA/GSTP1/FOLR2	1.6644896980556
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	6/106	300/9376	1.76905660377359	JUN/FOS/IL1B/IL1R1/FGF7/CD14	1.44767272877115
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/106	110/9376	2.41234991423671	DCN/FBN1/LTBP1	1.59327670449003
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/106	173/9376	2.04515214309085	NFKBIA/HLA-DQA2/HLA-DRA/IL1B	1.48366741881628
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	3/106	112/9376	2.36927223719677	NFKBIA/HLA-DQA2/HLA-DRA	1.55882816687445
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/106	120/9376	2.21132075471698	JUN/NFKBIA/YWHAE	1.42802829378131
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/106	122/9376	2.17506959480359	JUN/FOS/NFKBIA	1.39693905862349
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/106	69/9376	2.5638501503965	JUN/FOS	1.3941629218792
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/106	70/9376	2.52722371967655	NFKBIA/IRS2	1.37141488928646
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/106	70/9376	2.52722371967655	GSTP1/HSD11B1	1.37141488928646
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	2/106	70/9376	2.52722371967655	HLA-DQA2/HLA-DRA	1.37141488928646
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/106	71/9376	2.49162901939942	FOS/PRLR	1.34905766329445
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	5/106	275/9376	1.6082332761578	C1QC/C1QB/EGR1/C1QA/IL1B	1.0946887880319
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/106	205/9376	1.72590888173033	JUN/NFKBIA/HLA-DQA2/HLA-DRA	1.12369745623921
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/106	139/9376	1.9090538889643	JUN/FOS/MMP2	1.15459656512434
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	2/106	76/9376	2.32770605759682	OLR1/PLTP	1.24269903855004
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/106	22/9376	4.02058319039451	AOC1	1.51670864643124
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/106	79/9376	2.23931215667542	GSTP1/HSD11B1	1.18282785592255
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	6/106	362/9376	1.46606900865214	SPP1/FGF7/FN1/PRLR/ITGB8/YWHAE	0.967039998294942
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/106	148/9376	1.79296277409485	JUN/FOS/FGF7	1.03974913618305
NA	NA	hsa04081	Hormone signaling	4/106	219/9376	1.61557680709916	RAMP1/SLC40A1/PRLR/IRS2	0.985658344070443
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	3/106	154/9376	1.72310708159765	JUN/FOS/RGS2	0.967495870364914
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/106	87/9376	2.03339839514205	JUN/FOS	1.03547980055046
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/106	27/9376	3.27603074772886	FADS1	1.26641524753134
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	4/106	232/9376	1.52504879635654	TMSB4X/FGF7/FN1/ITGB8	0.865912989940406
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/106	163/9376	1.62796619979164	JUN/FOS/NFKBIA	0.864825006703196
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/106	93/9376	1.90221140190708	CST3/LYZ	0.934984290795685
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/106	93/9376	1.90221140190708	NFKBIA/FN1	0.934984290795685
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	3/106	168/9376	1.57951482479784	FTL/FTH1/IL1B	0.810466819638163
NA	NA	hsa04981	Folate transport and metabolism	1/106	31/9376	2.85331710286062	FOLR2	1.10519683198492
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	2/106	99/9376	1.78692586239756	IL1B/IL1R1	0.841678708962794
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/106	99/9376	1.78692586239756	JUN/FOS	0.841678708962794
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/106	99/9376	1.78692586239756	TPM1/ITGB8	0.841678708962794
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/106	34/9376	2.6015538290788	RORB	1.00036795381638
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/106	103/9376	1.71753068327532	COL15A1/SLC7A8	0.78297458171563
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/106	105/9376	1.6848158131177	TPM1/ITGB8	0.754577485401185
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/106	37/9376	2.39061703212647	IL1B	0.906268577794447
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/106	109/9376	1.62298770988402	NFKBIA/IRS2	0.699554976348628
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/106	41/9376	2.15738610216291	MMP2	0.794166811966564
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/106	116/9376	1.52504879635654	MMP2/THY1	0.608445764508585
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/106	42/9376	2.10601976639712	AOC1	0.76816115085096
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/106	43/9376	2.05704256252742	ABCA1	0.742873341105367
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/106	45/9376	1.96561844863732	ABCA1	0.694298809404752
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/106	122/9376	1.45004639653573	IRS2/CAB39L	0.535021408343559
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	3/106	205/9376	1.29443166129775	JUN/NFKBIA/YWHAE	0.455776361418693
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/106	47/9376	1.88197511039743	IRS2	0.648166252972358
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/106	49/9376	1.80515979976896	JUN	0.604237727838364
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	1/106	50/9376	1.76905660377359	IL1B	0.583034569811309
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	3/106	214/9376	1.23999294657027	JUN/FOS/NFKBIA	0.379759742849205
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	3/106	217/9376	1.22285018694027	JUN/FOS/FGF7	0.355154681644414
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	2/106	134/9376	1.32019149535342	CALD1/RAMP1	0.399188400537484
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/106	55/9376	1.6082332761578	PSAP	0.483747764455551
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/106	140/9376	1.26361185983828	SPP1/EGR1	0.336035921232284
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/106	56/9376	1.57951482479784	GAS1	0.465103182688077
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/106	226/9376	1.17415261312406	JUN/FOS/NFKBIA	0.283382072161232
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	3/106	227/9376	1.16898013465215	JUN/FOS/NFKBIA	0.275588106196761
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/106	57/9376	1.55180403839788	FADS1	0.446823854114134
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/106	59/9376	1.49920051167253	GSTP1	0.411302816685157
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/106	59/9376	1.49920051167253	IRS2	0.411302816685157
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/106	62/9376	1.42665855143031	IRS2	0.360418343454417
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/106	65/9376	1.36081277213353	PBX1	0.312132593670409
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/106	65/9376	1.36081277213353	SPP1	0.312132593670409
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/106	66/9376	1.34019439679817	HSD11B1	0.296567111516881
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/106	156/9376	1.13401064344461	NFKBIA/YWHAE	0.180482390603893
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/106	68/9376	1.3007769145394	CD14	0.266176354468254
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/106	250/9376	1.06143396226415	RAB31/DAB2/FOLR2	0.105277848875337
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/106	69/9376	1.28192507519825	CTSB	0.251334494222321
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/106	70/9376	1.26361185983828	JUN	0.236717924765647
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/106	72/9376	1.22851153039832	NFKBIA	0.208131694488332
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	2/106	166/9376	1.0656967492612	IRS2/RGS2	0.0913201914830122
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/106	73/9376	1.21168260532437	GSTP1	0.194148390860855
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/106	73/9376	1.21168260532437	FGF7	0.194148390860855
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/106	169/9376	1.04677905548733	CTSB/IRS2	0.065619729115236
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	1/106	75/9376	1.17937106918239	GSTP1	0.166769608844229
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/106	75/9376	1.17937106918239	IGFBP3	0.166769608844229
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/106	77/9376	1.14873805439843	NFKBIA	0.140135458497271
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/106	78/9376	1.13401064344461	BTG2	0.127083897794162
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/106	78/9376	1.13401064344461	FN1	0.127083897794162
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/106	178/9376	0.993852024591902	JUN/DKK1	-0.00885511333357717
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/106	82/9376	1.07869305108145	GSTP1	0.0765315800861905
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/106	86/9376	1.02852128126371	JUN	0.0284124774368366
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/106	86/9376	1.02852128126371	ITGB8	0.0284124774368366
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/106	87/9376	1.01669919757103	TPM1	0.0167328320340787
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/106	90/9376	0.982809224318658	IRS2	-0.0175227026846701
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	4/106	388/9376	0.911884847305972	APOE/DKK1/IL1B/IRS2	-0.189554296540964
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	1/106	97/9376	0.911884847305972	FOS	-0.093279150370263
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/106	98/9376	0.902579899884482	NR4A2	-0.103665233216478
NA	NA	hsa04519	Cadherin signaling	4/106	404/9376	0.875770595927517	NFKBIA/CDH11/LIMA1/YWHAE	-0.272941237182658
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/106	212/9376	0.834460662157351	FGF7/TLN1	-0.260690561597877
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/106	105/9376	0.84240790655885	JUN	-0.173645881578808
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	3/106	323/9376	0.821543314445937	TIMP3/TPM1/IRS2	-0.34900892044219
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/106	110/9376	0.804116638078902	TIMP1	-0.220976681628324
Genetic Information Processing	Translation	hsa03010	Ribosome	2/106	222/9376	0.796872344042155	MT-RNR2/RPL12	-0.327520730401545
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/106	115/9376	0.76915504511895	FOS	-0.266341639833537
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	3/106	333/9376	0.796872344042155	SPP1/FN1/ITGB8	-0.403583694816401
Organismal Systems	Immune system	hsa04611	Platelet activation	1/106	126/9376	0.702006588799042	TLN1	-0.360097222545057
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/106	133/9376	0.665058873599092	IRS2	-0.415993480376946
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/106	133/9376	0.665058873599092	GZMB	-0.415993480376946
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/106	133/9376	0.665058873599092	FOS	-0.415993480376946
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/106	138/9376	0.640962537599125	YWHAE	-0.454348432164853
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/106	138/9376	0.640962537599125	IRS2	-0.454348432164853
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/106	150/9376	0.589685534591195	FGF7	-0.541694512626024
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/106	154/9376	0.574369027199216	TPM1	-0.56948164243438
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/106	155/9376	0.570663420572124	PBX1	-0.576332928814953
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/106	157/9376	0.56339382285783	IGFBP3	-0.589924588585102
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/106	157/9376	0.56339382285783	YWHAE	-0.589924588585102
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/106	158/9376	0.559828039168856	YWHAE	-0.596665970676153
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	1/106	158/9376	0.559828039168856	CAB39L	-0.596665970676153
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/106	168/9376	0.526504941599281	PRLR	-0.66219537046405
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/106	170/9376	0.52031076581576	JUN	-0.674912778157319
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	1/106	170/9376	0.52031076581576	GSTP1	-0.674912778157319
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	1/106	184/9376	0.480721903199344	SEMA3B	-0.760681075447522
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/106	194/9376	0.455942423652986	TPM1	-0.818796140729518
NA	NA	hsa04082	Neuroactive ligand signaling	1/106	199/9376	0.44448658386271	P2RY14	-0.846972731059156
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/106	205/9376	0.431477220432582	MMP2	-0.88006582822234
NA	NA	hsa04382	Cornified envelope formation	1/106	217/9376	0.407616728980089	S100A8	-0.944076802982206
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	2/106	370/9376	0.478123406425293	P2RY14/PRLR	-1.09522011984807
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/106	238/9376	0.371650547011257	FGF7	-1.04993604784085
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/106	254/9376	0.348239488931808	FGF7	-1.12605232588047
NA	NA	hsa04517	IgSF CAM signaling	1/106	299/9376	0.295828863507288	NLGN4X	-1.32324831565514
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	1/106	308/9376	0.287184513599608	TGM2	-1.36017701852489
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	2/106	480/9376	0.368553459119497	DKK1/IL1B	-1.51865290004876
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/106	449/9376	0.196999621801067	RGS2	-1.86459646573492