category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	12/47	138/9376	17.3469010175763	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/MT-ND1/MT-ND4L/MT-ND5/MT-ND6	13.7310268950241
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	13/47	235/9376	11.0355817111815	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/NDUFAF2/MT-ND1/MT-ND4L/MT-ND5/MT-ND6	11.0585108573506
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	14/47	308/9376	9.06769825918762	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/MT-ND1/MT-ND4L/MT-ND5/DNAL1/ERN1/MT-ND6	10.2184793094897
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	12/47	205/9376	11.6774260508563	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/MT-ND1/MT-ND4L/MT-ND5/MT-ND6	10.9711506027968
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	13/47	268/9376	9.67672276913306	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/MT-ND1/MT-ND4L/MT-ND5/ERN1/MT-ND6	10.2288928231546
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/47	227/9376	10.5456931296279	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/MT-ND1/MT-ND4L/MT-ND5/MT-ND6	10.3335751977194
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	14/47	368/9376	7.58926919518964	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/MT-ND1/MT-ND4L/MT-ND5/DNAL1/ERN1/MT-ND6	9.15301115408222
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	12/47	275/9376	8.70499032882012	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/MT-ND1/MT-ND4L/MT-ND5/MT-ND6	9.20472691234206
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	13/47	388/9376	6.68392191270015	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/MT-ND1/MT-ND4L/MT-ND5/ERN1/MT-ND6	8.1161385903276
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	14/47	480/9376	5.81843971631206	MT-ND3/MT-CYB/MT-CO1/MT-ATP6/MT-CO3/MT-ND4/MT-ND2/MT-ATP8/MT-ND1/MT-ND4L/MT-ND5/DNAL1/ERN1/MT-ND6	7.69213118142057
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	7/47	149/9376	9.37198343567043	MT-ND3/MT-ND4/MT-ND2/MT-ND1/MT-ND4L/MT-ND5/MT-ND6	7.31152980868199
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/47	45/9376	13.2992907801418	ABCA4/ABCC3/DEFB1	5.87001555426965
NA	NA	hsa04518	Integrin signaling	4/47	154/9376	5.18154186239293	FLT1/FN1/ITGB8/LAMB1	3.71365257084605
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/47	157/9376	5.08253150833446	MT-CYB/MT-CO1/MT-CO3/ERN1	3.6614616067533
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/47	87/9376	6.87894350696992	MT-CYB/MT-CO1/MT-CO3	3.91013230299887
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/47	89/9376	6.72436050681329	FN1/ITGB8/LAMB1	3.85124615713875
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	3/47	93/9376	6.43514070006863	FN1/GADD45A/LAMB1	3.73873867804914
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/47	37/9376	10.7832087406555	PAX8/GADD45A	4.23203270219946
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	4/47	201/9376	3.969937546311	FLT1/PAX8/HPGD/GADD45A	3.02105985377136
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	4/47	203/9376	3.93082486112567	FLT1/FN1/ITGB8/LAMB1	2.99639600713711
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/47	42/9376	9.49949341438703	AOC1/IDO1	3.91832819549871
NA	NA	hsa04382	Cornified envelope formation	4/47	217/9376	3.67722325718208	KRT23/CLDN4/S100A1/KRT8	2.83209258629635
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	4/47	232/9376	3.43947175348496	FN1/SCIN/ITGB8/GSN	2.67047611645112
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	4/47	233/9376	3.42471007213953	FN1/FBLN1/ITGB8/VCAN	2.66017640923462
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	5/47	362/9376	2.75537792406254	FLT1/FN1/ERBB3/ITGB8/LAMB1	2.4175928430116
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/47	160/9376	3.74042553191489	CLDN4/ITGB8/VCAN	2.48155430786881
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/47	77/9376	5.18154186239293	MECOM/GADD45A	2.61505428296351
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/47	300/9376	2.65985815602837	FLT1/ERBB3/MECOM/GADD45A	2.07396480017704
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	2/47	98/9376	4.07121146330873	SCIN/GSN	2.1692649266544
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/47	99/9376	4.0300881151945	KRT23/DEFB1	2.15122629445622
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	2/47	103/9376	3.87357983887626	FN1/LAMB1	2.08136751044632
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/47	22/9376	9.06769825918762	AOC1	2.68892893801503
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/47	30/9376	6.64964539007092	ABCC3	2.19981393626823
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/47	31/9376	6.43514070006863	PCCA	2.15138930776442
NA	NA	hsa04981	Folate transport and metabolism	1/47	31/9376	6.43514070006863	ABCC3	2.15138930776442
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/47	32/9376	6.23404255319149	PCCA	2.10505207570799
Human Diseases	Immune disease	hsa05310	Asthma	1/47	32/9376	6.23404255319149	PRG2	2.10505207570799
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/47	137/9376	2.91225345550551	GADD45A/ERN1	1.60033268399268
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/47	37/9376	5.39160437032777	IDO1	1.89972572425188
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1/47	48/9376	4.15602836879433	PCCA	1.55590927226113
NA	NA	hsa03272	Virion - Hepatitis viruses	1/47	48/9376	4.15602836879433	CLDN4	1.55590927226113
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/47	50/9376	3.98978723404255	AOC1	1.50450834311264
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	3/47	333/9376	1.79720145677592	FN1/ITGB8/LAMB1	1.05135880351824
Cellular Processes	Cell motility	hsa04814	Motor proteins	2/47	194/9376	2.05659135775389	DNAL1/KIF12	1.05549527984778
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	1/47	59/9376	3.38117562206996	GADD45A	1.30225611792905
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/47	63/9376	3.16649780479568	MECOM	1.22461830621102
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/47	63/9376	3.16649780479568	HPGD	1.22461830621102
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/47	63/9376	3.16649780479568	GADD45A	1.22461830621102
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	2/47	204/9376	1.95577805590321	FN1/ERBB3	0.979618857138931
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	2/47	205/9376	1.94623767514271	SCIN/GSN	0.972267659882172
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/47	73/9376	2.73273098222093	GADD45A	1.05486791047711
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/47	73/9376	2.73273098222093	GADD45A	1.05486791047711
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/47	75/9376	2.65985815602837	GADD45A	1.02436281970735
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/47	75/9376	2.65985815602837	PAX8	1.02436281970735
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/47	76/9376	2.62486002239642	GADD45A	1.00948134118345
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/47	77/9376	2.59077093119646	GADD45A	0.994836946211652
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/47	78/9376	2.55755591925805	FN1	0.980422340229296
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/47	80/9376	2.4936170212766	ERBB3	0.952254888416566
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/47	86/9376	2.31964374072241	ERBB3	0.872599764474548
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	1/47	86/9376	2.31964374072241	ITGB8	0.872599764474548
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	1/47	87/9376	2.29298116898997	GADD45A	0.859972107240528
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/47	88/9376	2.26692456479691	SERPINE2	0.847516203675585
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/47	90/9376	2.21654846335697	ABCC3	0.823101418592637
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/47	254/9376	1.5707823756073	FLT1/ERBB3	0.654574977787533
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/47	95/9376	2.09988801791713	FLT1	0.76476835267251
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	1/47	99/9376	2.01504405759725	ITGB8	0.720635632932601
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/47	100/9376	1.99489361702128	CXCL14	0.709926348733291
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/47	101/9376	1.97514219507057	FN1	0.699340528566684
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/47	105/9376	1.89989868287741	GADD45A	0.658175930044101
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/47	105/9376	1.89989868287741	CLEC4E	0.658175930044101
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	1/47	105/9376	1.89989868287741	ITGB8	0.658175930044101
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	1/47	110/9376	1.81353965183752	FLT1	0.60918042636699
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/47	112/9376	1.78115501519757	LAMB1	0.590288040289185
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/47	116/9376	1.71973587674248	PCCA	0.553622425170592
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	1/47	116/9376	1.71973587674248	CLDN4	0.553622425170592
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	1/47	133/9376	1.49992001279795	GADD45A	0.412132522628018
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	1/47	138/9376	1.44557508479803	FN1	0.374272987065622
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	1/47	139/9376	1.43517526404408	KRT23	0.366879250738503
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/47	144/9376	1.38534278959811	ERN1	0.330748288689199
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	1/47	148/9376	1.34790109258194	GADD45A	0.302795821729324
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	1/47	150/9376	1.32992907801418	GADD45A	0.289118923664221
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/47	154/9376	1.29538546559823	IDO1	0.262333615161199
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/47	156/9376	1.27877795962902	CLDN4	0.249213918850673
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/47	157/9376	1.27063287708362	GADD45A	0.242719961118219
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	1/47	157/9376	1.27063287708362	DLG5	0.242719961118219
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/47	158/9376	1.26259089684891	GADD45A	0.236269073727639
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/47	169/9376	1.18041042427294	ERN1	0.16798207021359
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	1/47	170/9376	1.17346683354193	CLDN4	0.162002772470611
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	1/47	170/9376	1.17346683354193	GADD45A	0.162002772470611
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1/47	174/9376	1.14649058449499	ERN1	0.138439570145743
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/47	178/9376	1.12072675113555	NOTUM	0.115420734237713
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	1/47	181/9376	1.10215116962501	CLEC4E	0.098497177326059
NA	NA	hsa04519	Cadherin signaling	2/47	404/9376	0.987571097535285	KRT23/KRT8	-0.0181257443646315
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/47	193/9376	1.03362363576232	CXCL14	0.0335002505669716
NA	NA	hsa04082	Neuroactive ligand signaling	1/47	199/9376	1.00245910403079	TAC3	0.00248868594245778
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/47	200/9376	0.997446808510638	CLDN4	-0.00259053046565737
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	1/47	205/9376	0.973118837571354	GADD45A	-0.0276206344092885
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	1/47	212/9376	0.940987555198715	FLT1	-0.0616859159870083
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	1/47	216/9376	0.923561859732072	ERN1	-0.0806689253717637
Genetic Information Processing	Translation	hsa03010	Ribosome	1/47	222/9376	0.898600728387962	MT-RNR1	-0.108523274439694
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	1/47	238/9376	0.838190595387091	FLT1	-0.179466619424953
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/47	298/9376	0.669427388262173	CXCL14	-0.411620439915402
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	1/47	323/9376	0.617614122916804	ERBB3	-0.496390961888427
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1/47	370/9376	0.539160437032777	TAC3	-0.641950686228892