category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	3/5	275/9376	20.4567272727273	EGR1/CREB5/NDUFS4	7.56430884662429
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/5	115/9376	32.6121739130435	EGR1/CREB5	7.87865370368145
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	2/5	224/9376	16.7428571428571	EGR1/CREB5	5.50842231999852
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	2/5	227/9376	16.5215859030837	CCL3/CREB5	5.46814319581018
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/5	235/9376	15.9591489361702	CREB5/NDUFS4	5.364405933564
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/5	308/9376	12.1766233766234	CREB5/NDUFS4	4.6068905083195
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/5	44/9376	42.6181818181818	CREB5	6.39145518012817
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/5	49/9376	38.269387755102	CREB5	6.04166974045786
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/5	65/9376	28.8492307692308	CREB5	5.20414502149924
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/5	69/9376	27.1768115942029	CREB5	5.04096993253686
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/5	75/9376	25.0026666666667	CREB5	4.82062085089907
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/5	86/9376	21.8046511627907	CREB5	4.47692148907777
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/5	90/9376	20.8355555555556	CREB5	4.36746019194064
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/5	93/9376	20.1634408602151	EGR1	4.28991276818366
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/5	95/9376	19.7389473684211	CCL3	4.24020915272998
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/5	98/9376	19.134693877551	CREB5	4.16844191350995
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/5	100/9376	18.752	CCL3	4.12234742522109
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	1/5	101/9376	18.5663366336634	EGR1	4.09979933160897
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/5	103/9376	18.2058252427184	CCL3	4.0556611389408
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	1/5	106/9376	17.6905660377358	CREB5	3.99173592309832
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/5	107/9376	17.5252336448598	CREB5	3.97100768678398
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	1/5	109/9376	17.2036697247706	CCL3	3.93038163064614
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	1/5	109/9376	17.2036697247706	CREB5	3.93038163064614
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/5	115/9376	16.3060869565217	CREB5	3.81471261737913
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	1/5	119/9376	15.7579831932773	CREB5	3.7423381912685
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/5	122/9376	15.3704918032787	CREB5	3.69032376914491
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	1/5	122/9376	15.3704918032787	CREB5	3.69032376914491
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/5	130/9376	14.4246153846154	CREB5	3.56019884564388
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	1/5	133/9376	14.0992481203008	CREB5	3.51433682935615
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/5	138/9376	13.5884057971014	NDUFS4	3.44111328249538
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	1/5	139/9376	13.4906474820144	CREB5	3.42692461806289
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/5	140/9376	13.3942857142857	EGR1	3.41288166692735
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/5	142/9376	13.2056338028169	TREM2	3.38522270052416
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/5	149/9376	12.5852348993289	NDUFS4	3.29264863820592
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	1/5	154/9376	12.1766233766234	CREB5	3.23024966026996
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	1/5	155/9376	12.098064516129	CREB5	3.21811644509063
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/5	157/9376	11.943949044586	NDUFS4	3.19418195909716
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/5	163/9376	11.5042944785276	CREB5	3.1249122488465
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/5	166/9376	11.2963855421687	CREB5	3.09162418812622
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/5	191/9376	9.81780104712042	CREB5	2.84390490642458
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/5	193/9376	9.7160621761658	CCL3	2.82607936107589
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	1/5	205/9376	9.14731707317073	CREB5	2.72433728111045
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/5	205/9376	9.14731707317073	NDUFS4	2.72433728111045
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	1/5	216/9376	8.68148148148148	CCL3	2.63816405065659
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	1/5	217/9376	8.64147465437788	CREB5	2.63063555604097
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/5	226/9376	8.29734513274336	CREB5	2.56499327589602
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	1/5	227/9376	8.26079295154185	NDUFS4	2.55792519025212
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/5	268/9376	6.99701492537313	NDUFS4	2.30074606109889
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	1/5	298/9376	6.29261744966443	CCL3	2.14467366294166
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	1/5	333/9376	5.63123123123123	CREB5	1.98765034329943
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	1/5	362/9376	5.18011049723757	CREB5	1.87353125219571
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	1/5	368/9376	5.09565217391304	NDUFS4	1.85144348058656
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	1/5	388/9376	4.83298969072165	NDUFS4	1.7811465479733
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	1/5	480/9376	3.90666666666667	NDUFS4	1.51006670905482