category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	23/311	100/9376	6.9340192926045	CD9/HLA-DRB5/HLA-DRB1/CD59/CD2/CD7/CSF3R/HLA-DQB1/ITGA1/HLA-DPA1/IL1R2/CD3G/CD3D/HLA-DRA/CSF1/CSF3/IL7R/CD3E/CD37/ITGA4/IL2RA/ITGAM/ITGA3	11.0497006464896
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	31/311	224/9376	4.17225539733578	HLA-C/HLA-DRB5/CCND1/HLA-DRB1/HLA-A/B2M/HLA-E/HLA-B/IL2RG/HLA-DQB1/HLA-DPA1/TGFB1/IL1R2/CD3G/CD3D/HLA-DRA/ITGB2/BAX/ITGAL/IL2RB/CD3E/CDKN2A/ETS1/SLC25A4/IL2RA/BCL2L1/SLC2A1/ADCY4/CCND3/LCK/TSPO	8.90053427422013
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/311	160/9376	4.52218649517685	HLA-C/HLA-DRB5/HLA-DRB1/PTPRC/HLA-A/CD2/HLA-E/HLA-B/HLA-DQB1/HLA-DPA1/NRCAM/HLA-DRA/ITGB2/CLDN5/ITGAL/SDC4/ITGA4/CTLA4/L1CAM/ITGAM/NFASC/SIGLEC1/ITGA9/SPN	8.32306017109592
NA	NA	hsa04518	Integrin signaling	23/311	154/9376	4.50260993026266	CCND1/FGG/RAC2/FGB/ITGA1/TGFB1/ITGB4/PDGFD/ITGAX/ITGB2/SPP1/COL1A1/ITGAL/FGA/RELN/LAMB2/ITGA4/KDR/ITGAM/ITGA9/LAMC2/CCND3/ITGA3	8.11748518320004
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	21/311	133/9376	4.76019631071247	HLA-C/HLA-A/RAC2/HLA-E/HCST/HLA-B/CD247/FCGR3A/ITGB2/PRF1/LCP2/KLRC1/ITGAL/CD48/FCER1G/TYROBP/LAT2/ZAP70/KLRC2/TNFSF10/LCK	8.08931582249988
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/311	70/9376	6.46026642168121	HLA-C/HLA-DRB5/CCND1/HLA-DRB1/HLA-A/RAC2/HLA-E/HLA-B/HLA-DQB1/HLA-DPA1/HLA-DRA/ITGB2/PRF1/ITGAL/CAV1	8.49304173202953
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/311	93/9376	5.51090827369222	HLA-DRB5/HLA-DRB1/STAT1/CD247/IL2RG/HLA-DQB1/HLA-DPA1/CD3G/CD3D/HLA-DRA/IL2RB/CD3E/IL2RA/RUNX3/ZAP70/LCK/NOTCH1	8.09735581742917
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/311	82/9376	5.88251901811623	HLA-C/HLA-DRB5/HLA-DRB1/HLA-A/CTSS/B2M/HLA-E/HLA-B/CD74/HSP90AA1/HLA-DQB1/HLA-DPA1/HLA-DRA/KLRC1/CTSL/KLRC2	8.22491586685003
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/311	100/9376	5.12514469453376	CCL5/CCL21/CCL18/XCL2/XCL1/IL2RG/CCL2/CSF1/CCR5/IL2RB/CXCR4/TNFRSF14/IL2RA/IL10RA/ACKR3/CCL4/TNFSF10	7.68140643810524
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	30/311	298/9376	3.03502449340728	CCL5/CCL21/CCL18/PRL/IL32/XCL2/XCL1/CSF3R/IL2RG/LTB/TGFB1/IL1R2/CCL2/CSF1/TNFRSF11B/CSF3/CCR5/TNFRSF18/IL2RB/IL7R/INHBB/CXCR4/TNFRSF14/IL2RA/TNFRSF4/IL10RA/BMP6/ACKR3/CCL4/TNFSF10	6.61248366297286
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	17/311	109/9376	4.701967609664	HLA-DRB5/HLA-DRB1/STAT1/CD247/IL2RG/HSP90AA1/HLA-DQB1/HLA-DPA1/TGFB1/CD3G/CD3D/HLA-DRA/IL2RB/CD3E/IL2RA/ZAP70/LCK	7.2004263167817
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	22/311	180/9376	3.68474455162558	HLA-C/CCL5/HLA-DRB5/HLA-DRB1/HLA-A/BST2/B2M/HLA-E/HLA-B/CD74/STAT1/HLA-DQB1/HLA-DPA1/CCL2/IFIH1/HLA-DRA/BAX/IRF7/TNFRSF14/BCL2L1/OAS2/BIRC3	6.7363038668264
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	11/311	45/9376	7.36948910325116	HLA-C/HLA-DRB5/HLA-DRB1/HLA-A/HLA-E/HLA-B/HLA-DQB1/HLA-DPA1/HLA-DRA/PRF1/KLRC1	7.93283990303795
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	23/311	205/9376	3.38244843541683	HLA-C/HLA-DRB5/CCND1/HLA-DRB1/HLA-A/ISG15/B2M/HLA-E/HLA-B/STAT1/CD247/HLA-DQB1/HLA-DPA1/CD3G/CD3D/HLA-DRA/BAX/ITGAL/IRF7/CD3E/OAS2/RUNX3/CCND3	6.38813406704299
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/311	39/9376	7.73023332508863	HLA-C/HLA-DRB5/HLA-DRB1/HLA-A/HLA-E/HLA-B/HLA-DQB1/HLA-DPA1/HLA-DRA/PRF1	7.80082747960016
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	24/311	233/9376	3.10536411685964	ANKRD1/ENO1/ENO2/TTN/ITGA1/ITGB4/SYNE2/SUN2/COL1A1/SDC4/TPM3/BGN/ITGA4/FLNC/COL27A1/INF2/PDLIM1/JUP/ITGA9/FHL1/PDLIM3/ACTG2/ITGA3/AMPD3	6.02757670553623
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	14/311	88/9376	4.79625840397545	FGG/CFH/C1QA/CD59/CLU/C1QB/F2RL3/FGB/ITGAX/ITGB2/THBD/FGA/SERPINE1/ITGAM	6.62701460255149
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	31/311	362/9376	2.58172709669397	CCND1/PRL/CSF3R/IL2RG/HSP90AA1/ITGA1/ITGB4/GNG11/PDGFD/CSF1/SPP1/COL1A1/HSP90B1/CSF3/IL2RB/IL7R/RELN/PKN1/LAMB2/ITGA4/IL2RA/BCL2L1/KDR/DDIT4/PIK3AP1/ITGA9/LAMC2/FGFR1/YWHAH/CCND3/ITGA3	5.68471886217785
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/311	54/9376	6.14124091937597	HLA-C/HLA-DRB5/HLA-DRB1/HLA-A/HLA-E/HLA-B/HLA-DQB1/HLA-DPA1/HLA-DRA/PRF1/CTLA4	7.01765824506489
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/311	44/9376	6.85179771996492	HLA-C/HLA-DRB5/HLA-DRB1/HLA-A/HLA-E/HLA-B/HLA-DQB1/HLA-DPA1/HLA-DRA/PRF1	7.20626464211895
NA	NA	hsa04517	IgSF CAM signaling	27/311	299/9376	2.72238651883556	FGG/CD2/FGB/CD96/NRCAM/ITGAX/ITGB2/LCP2/ROBO4/ITGAL/RHOA/CD48/FGA/MYL12A/BAIAP2/EZR/ITGA4/KDR/L1CAM/ITGAM/NFASC/RAP1A/FGFR1/LCK/CD84/SLAMF7/SLAMF1	5.60630824696359
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	20/311	181/9376	3.3312607699277	HLA-DRB5/HLA-DRB1/CTSD/CTSS/CD74/STAT1/HLA-DQB1/HLA-DPA1/TGFB1/ITGAX/HLA-DRA/FCGR3A/ITGB2/CORO1A/BAX/RHOA/CALM1/FCER1G/ITGAM/IL10RA	5.86592093084375
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	14/311	95/9376	4.44284988999831	CCL5/HLA-DRB5/HLA-DRB1/HLA-DQB1/LTB/HLA-DPA1/TGFB1/CCL2/HLA-DRA/ITGB2/CSF1/ITGAL/CTSL/CTLA4	6.24689825409778
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	12/311	78/9376	4.63813999505318	HLA-DRB5/HLA-DRB1/STAT1/HLA-DQB1/HLA-DPA1/TGFB1/HLA-DRA/FCGR3A/ITGB2/ITGA4/ITGAM/CYBB	5.97604508898273
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	20/311	203/9376	2.97023743525573	CCND1/RAC2/ITGA1/ITGB4/PDGFD/SPP1/COL1A1/RHOA/CAV1/MYL12A/RELN/LAMB2/ITGA4/KDR/RAP1A/ITGA9/LAMC2/CCND3/ITGA3/BIRC3	5.25645338369638
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/311	142/9376	3.39694760201078	RAC2/GSTT1/HSP90AA1/IL1R2/CCL2/KLF2/THBD/HSP90B1/RHOA/CALM1/SDC4/CAV1/PRKCZ/KDR/CTSL/EDN1	5.33076706562616
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	14/311	112/9376	3.76848874598071	HLA-DRB5/HLA-DRB1/STAT1/HLA-DQB1/HLA-DPA1/TGFB1/HLA-DRA/CCR5/LAMB2/BCL2L1/IL10RA/GNAI2/LAMC2/BIRC3	5.45926818053251
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	13/311	99/9376	3.95881646042418	HLA-DRB5/HLA-DRB1/FGG/CFH/C1QA/C1QB/HLA-DQB1/HLA-DPA1/HLA-DRA/FCGR3A/ITGB2/ITGAL/ITGAM	5.48168118821164
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	20/311	214/9376	2.81756167923791	HLA-C/SAMHD1/HLA-A/BST2/RAC2/B2M/HLA-E/HLA-B/CD247/GNG11/CD3G/CD3D/BAX/CALM1/CCR5/CD3E/CXCR4/BCL2L1/GNAI2/APOBEC3G	4.98176031934789
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/311	116/9376	3.63854085818827	THY1/RAC2/ITGB2/CLDN5/ITGAL/RHOA/MYL12A/EZR/CXCR4/ITGA4/ITGAM/RAP1A/GNAI2/CYBB	5.29625946873718
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/311	50/9376	5.42662379421222	HBB/HBA2/HBA1/TGFB1/CCL2/ITGB2/ITGAL/CSF3/KLRB1	5.81288644715379
Human Diseases	Infectious disease: viral	hsa05162	Measles	15/311	136/9376	3.32513712880651	CCND1/STAT1/IL2RG/CD3G/CD3D/IFIH1/BAX/IL2RB/IRF7/CD3E/IL2RA/BCL2L1/OAS2/CCND3/SLAMF1	5.0589917163329
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	16/311	155/9376	3.11204231926149	HLA-C/HLA-DRB5/HLA-DRB1/HLA-A/CTSS/HLA-E/HLA-B/HLA-DQB1/HLA-DPA1/HLA-DRA/FCGR3A/ITGB2/CORO1A/CTSL/ITGAM/CYBB	4.91090329953036
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	17/311	173/9376	2.96251138412356	CCL5/HLA-DRB5/HLA-DRB1/TPSAB1/STAT1/HLA-DQB1/HLA-DPA1/CCL2/IFIH1/HLA-DRA/BAX/RSAD2/IRF7/SLC25A4/OAS2/CCND3/TNFSF10	4.8256125988732
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	20/311	227/9376	2.65620352139609	HLA-C/CCL5/CCND1/HLA-A/RAC2/B2M/HLA-E/HLA-B/GNG11/CCL2/BAX/RHOA/CALM1/CCR5/CDKN2A/CXCR4/IL10RA/GNAI2/ADCY4/CCL4	4.67866281176439
Organismal Systems	Immune system	hsa04611	Platelet activation	14/311	126/9376	3.34976777420507	FGG/F2RL3/FGB/COL1A1/LCP2/RHOA/VAMP8/FGA/MYL12A/FCER1G/PRKCZ/RAP1A/GNAI2/ADCY4	4.91837092034455
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	18/311	193/9376	2.81172217316695	CCL5/CCL21/CCL18/RAC2/XCL2/STAT1/XCL1/GNG11/CCL2/RHOA/CCR5/CXCR4/PRKCZ/PREX1/RAP1A/GNAI2/ADCY4/CCL4	4.71042279955043
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	20/311	232/9376	2.59895775584876	RGCC/RAC2/ITGA1/ITGB4/PDGFD/ITGAX/ITGB2/ITGAL/RHOA/MYL12A/BAIAP2/CYFIP2/EZR/CXCR4/ITGA4/ITGAM/ITGA9/FGFR1/IQGAP2/ITGA3	4.56767086485984
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	11/311	89/9376	3.72614617580115	ITGA1/ITGB4/SPP1/COL1A1/SDC4/RELN/LAMB2/ITGA4/ITGA9/LAMC2/ITGA3	4.78617250998374
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	8/311	50/9376	4.82366559485531	HLA-DRB5/HLA-DRB1/HLA-DQB1/HLA-DPA1/TGFB1/HLA-DRA/CXCR4/ITGA4	5.02110297781431
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	7/311	38/9376	5.55356236249788	PTPRC/IL2RG/CD3D/IL7R/CD3E/ZAP70/LCK	5.2095244512756
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	24/311	333/9376	2.17282234002491	HLA-C/CCND1/HLA-A/WNT5A/ISG15/HLA-E/HLA-B/STAT1/ITGA1/ITGB4/IRF1/SPP1/COL1A1/BAX/LFNG/RELN/LAMB2/ITGA4/PRKCZ/ITGA9/LAMC2/CCND3/NOTCH1/ITGA3	4.03626813840441
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/311	101/9376	3.2834357390723	CCND1/STAT1/TGFB1/CCL2/COL1A1/BAX/THBD/SERPINE1/PRKCZ/EDN1/CYBB	4.27340890192702
Human Diseases	Immune disease	hsa05310	Asthma	6/311	32/9376	5.65273311897106	HLA-DRB5/HLA-DRB1/HLA-DQB1/HLA-DPA1/HLA-DRA/FCER1G	4.88313403117071
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	11/311	103/9376	3.21967970530391	CCL5/C1QA/C1QB/CD247/TGFB1/CD3G/CD3D/CCL2/SERPINE1/CD3E/GNAI2	4.19547098774082
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/311	75/9376	3.61774919614148	CCND1/IGFBP3/PPP1R13L/BAX/SERPINE1/CDKN2A/BCL2L1/CCND3/PERP	4.21575897154146
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	15/311	184/9376	2.45771005172655	WNT5A/RAC2/SEMA3A/NTN4/ABLIM3/RHOA/ABLIM2/MYL12A/CXCR4/PRKCZ/L1CAM/GNAI2/DPYSL2/SEMA4D/SEMA3D	3.6987670546189
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	15/311	187/9376	2.41828154822291	CCL5/STAT1/HSP90AA1/CCL2/RHOA/GBP4/IRF7/GBP5/PSTPIP1/PKN1/BCL2L1/OAS2/CYBB/TRPV2/BIRC3	3.62853284643638
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/311	66/9376	3.65429211731463	HLA-DRB5/HLA-DRB1/STAT1/IL2RG/HLA-DQB1/HLA-DPA1/TGFB1/HLA-DRA	4.00800055580135
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	10/311	99/9376	3.04524343109552	TTN/ITGA1/TGFB1/ITGB4/ATP2A3/TPM3/ITGA4/EDN1/ITGA9/ITGA3	3.78914089180864
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	16/311	212/9376	2.27531395983741	RAC2/F2RL3/PDGFD/ITGB2/CSF1/LCP2/ITGAL/RHOA/CALM1/PRKCZ/KDR/ITGAM/RAP1A/GNAI2/ADCY4/FGFR1	3.47875971585996
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	13/311	157/9376	2.49632375529932	HLA-C/CCND1/HLA-A/HLA-E/HLA-B/IGFBP3/TGFB1/CALM1/SERPINE1/CDKN2A/ETS1/SLC25A4/CCND3	3.50199416369052
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	17/311	238/9376	2.1534221405604	FGG/C1QA/ISG15/C1QB/STAT1/RPS26/FGB/RPS27L/CCL2/IFIH1/CSF3/FGA/OAS2/RPLP2/RPS21/RPL38/CYBB	3.33835958329215
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	10/311	105/9376	2.87122952074721	TTN/ITGA1/TGFB1/ITGB4/ATP2A3/TPM3/ITGA4/ADCY4/ITGA9/ITGA3	3.57141524256835
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	10/311	110/9376	2.74071908798597	GAPDH/ENO1/ENO2/PFKP/EGLN3/SERPINE1/PGK1/EDN1/SLC2A1/CYBB	3.40142433730127
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	13/311	168/9376	2.3328739856071	CCND1/PRL/STAT1/CSF3R/IL2RG/CSF3/IL2RB/IL7R/IL2RA/BCL2L1/IL10RA/FHL1/CCND3	3.22881383717377
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/311	250/9376	2.05005787781351	HLA-C/HLA-A/HLA-E/HLA-B/IL2RG/WIPF1/ACAP1/RHOA/CCR5/CAV1/IL2RB/ASAP1/RAB11FIP1/CXCR4/PRKCZ/IL2RA/ARAP2	3.11691485000368
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/311	78/9376	3.09209333003545	C1QA/C1QB/IRF1/ITGB2/RHOA/CALM1/ITGAM/GNAI2	3.43649339707972
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/311	138/9376	2.40309427279929	RAC2/WIPF1/CCL2/SKAP2/LCP2/RHOA/BAIAP2/PKN1/ITGA4/ZAP70/LCK	3.07552558802544
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	10/311	122/9376	2.47114016129882	PTPRC/CD247/CD3G/CD3D/LCP2/RHOA/CD3E/CTLA4/ZAP70/LCK	3.0293618222905
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	14/311	204/9376	2.0689742134796	CCND1/WNT5A/LUM/TGFB1/COL1A1/RHOA/SDC4/CAV1/GPC3/EZR/KDR/HCLS1/CTSL/FGFR1	2.85911891160973
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/311	125/9376	2.41183279742765	CTSD/RAC2/BAX/RHOA/ASAH1/FCER1G/PRKCZ/GNAI2/SMPD1/ORMDL2	2.94324124632734
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	8/311	90/9376	2.67981421936406	STAT1/CD247/CD3G/CD3D/BATF/CD3E/ZAP70/LCK	2.96585624342852
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/311	168/9376	2.1534221405604	FTL/GLUL/STAT1/HSP90AA1/BAX/FTH1/SLC25A4/ZBP1/TNFSF10/CYBB/SMPD1/BIRC3	2.79410162382883
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/311	93/9376	2.59336859938457	CCND1/BAX/LAMB2/BCL2L1/RARB/LAMC2/ITGA3/BIRC3	2.86019393761141
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	7/311	75/9376	2.81380493033226	GAPDH/ENO1/ENO2/GLUL/PFKP/TPI1/PGK1	2.92104546109508
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/311	77/9376	2.74071908798597	CCND1/RAC2/STAT1/TGFB1/BAX/CDKN2A/BCL2L1	2.84078168191945
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	13/311	205/9376	1.91181868088777	CTSD/GAPDH/RAC2/TGFB1/NDUFA13/COL1A1/ATP2A3/SLC25A4/PRKCZ/NDUFA4L2/COX7A1/SLC2A1/CYBB	2.4448881628476
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	8/311	105/9376	2.29698361659776	CCL21/LTB/PPP1R13L/BCL2L1/ZAP70/CCL4/LCK/BIRC3	2.47541362848371
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	6/311	67/9376	2.6998128329414	GAPDH/ENO1/ENO2/PFKP/TPI1/PGK1	2.58624055944235
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/311	86/9376	2.45389964854558	ITGA1/ITGB4/ATP2A3/ITGA4/JUP/ITGA9/ITGA3	2.50875198249501
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	12/311	196/9376	1.84579040619463	HLA-C/CCND1/HLA-A/HLA-E/HLA-B/STAT1/GNG11/BAX/CALM1/CCR5/IRF7/PREX1	2.21641651850576
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/311	73/9376	2.47791040831608	SAMHD1/BST2/CCR5/CXCR4/MAP1B/APOBEC3G	2.34790194602441
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/311	200/9376	1.80887459807074	GAPDH/WIPF1/BAX/CLDN5/RHOA/BAIAP2/CYFIP2/EZR/HCLS1/MYO1G/MYO1F/TNFSF10	2.14166441613332
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/311	157/9376	1.92024904253794	CCND1/WNT5A/TGFB1/ITGB2/SERPINE1/PRKCZ/BMP6/YWHAH/CCND3/BIRC3	2.15374965791744
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	14/311	248/9376	1.70189814334613	S100A10/GAPDH/PTPRC/PODXL/HSP90AA1/BAX/RHOJ/HSP90B1/RHOA/MYL12A/CYFIP2/PKN1/TNFSF10/BIRC3	2.07488507538836
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/311	75/9376	2.41183279742765	GSTT1/BAX/CDKN2A/BCL2L1/TOP2A/BIRC3	2.27368870587189
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	9/311	137/9376	1.98051963292417	CTSD/CTSS/CTSW/BAX/PRF1/BCL2L1/CTSL/TNFSF10/BIRC3	2.14134193690817
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/311	23/9376	3.93233608276248	CPA3/LNPEP/PRCP	2.60785910354002
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/311	205/9376	1.76475570543487	HLA-C/CCND1/HLA-A/HLA-E/HLA-B/BAX/RHOA/CCR5/IRF7/CDKN2A/YWHAH/CCND3	2.05056357242806
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/311	142/9376	1.91078302613106	STAT1/TGFB1/FCGR3A/CSF1/LCP2/TNFRSF11B/ATP2A3/TYROBP/LCK	2.02556457869911
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/311	42/9376	2.87122952074721	FTL/CP/FTH1/CYBB	2.25112564624994
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/311	238/9376	1.6467345780756	RAC2/GNG11/PDGFD/CSF1/RHOA/CALM1/ETS1/BCL2L1/KDR/RASAL3/ZAP70/RAP1A/FGFR1	1.87184943018009
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/311	103/9376	2.04888708519339	TGFB1/IL1R2/ITGB2/COL1A1/LAMB2/ITGAM/LAMC2	1.98252717490266
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	12/311	216/9376	1.67488388710254	CCL5/HSP90AA1/CCL2/BAX/HSP90B1/RHOA/CALM1/IRF7/BCL2L1/RAP1A/TNFSF10/CYBB	1.85861794815454
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/311	83/9376	2.1793669856274	CCL5/SAMHD1/IRF7/ZBP1/CCL4/TREX1	1.9989041626271
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/311	85/9376	2.12808776243616	TYMP/PNP/UPP1/CMPK2/AK4/AMPD3	1.93509837980622
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/311	130/9376	1.85525599802127	RXFP1/TGFB1/GNG11/COL1A1/PRKCZ/EDN1/GNAI2/ADCY4	1.81874908873444
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/311	49/9376	2.46105387492618	GALNT18/LFNG/GALNT6/GALNT1	1.89921971797471
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	5/311	70/9376	2.1534221405604	TGFB1/EGLN3/ETS1/RAP1A/SLC2A1	1.79406307639658
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	6/311	93/9376	1.94502644953843	RAC2/RHOA/MYL12A/BAIAP2/RAP1A/FGFR1	1.6963801865408
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/311	32/9376	2.82636655948553	BAX/BCL2L1/BIRC3	1.91680727692119
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	8/311	140/9376	1.72273771244832	CCND1/GNG11/KLF2/SPP1/CALM1/SERPINE1/GNAI2/ADCY4	1.59582292981672
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/311	73/9376	2.0649253402634	CCND1/PDGFD/BAX/CDKN2A/FGFR1	1.6918077474155
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	8/311	143/9376	1.68659636183752	HLA-DRB5/HLA-DRB1/C1QA/C1QB/HLA-DQB1/HLA-DPA1/HLA-DRA/FCGR3A	1.53242781872467
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/311	120/9376	1.75862808145766	ARHGDIB/BAX/MATK/SH2B3/RHOA/CALM1/RAP1A	1.54913687955682
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/311	17/9376	3.54681293739361	GLUL/CA12	1.94665375972964
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	5/311	77/9376	1.95765649141855	CCND1/TGFB1/BAX/CDKN2A/BCL2L1	1.56285585489885
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	9/311	170/9376	1.59606582182712	CCND1/SYNPO/CLDN5/RHOA/MYL12A/EZR/PRKCZ/HCLS1/RAP1A	1.45266383351788
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	10/311	195/9376	1.54604666501773	FGG/RAC2/FGB/FCGR3A/ITGB2/ITGAL/FGA/SLC25A4/ITGAM/CYBB	1.42719724758603
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/311	36/9376	2.5123258306538	GALNT18/GALNT6/GALNT1	1.68385662818192
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/311	37/9376	2.44442513252803	HBB/HBA2/HBA1	1.63052566538418
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/311	37/9376	2.44442513252803	CCND1/BAX/TPM3	1.63052566538418
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	13/311	275/9376	1.4251739257527	CCL5/C1QA/RAC2/C1QB/NDUFA13/BAX/CAV1/SOD1/SLC25A4/NDUFA4L2/COX7A1/CYBB/NOTCH1	1.3254713390299
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/311	103/9376	1.75618893016577	COL8A1/COL1A1/CPA3/COL27A1/DPP4/PRCP	1.42929122169312
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	12/311	250/9376	1.44709967845659	CTSD/CTSS/LAPTM5/CTSW/VAMP8/ASAH1/OSBPL3/GNPTAB/CTSL/SMPD1/HYAL2/NAPSA	1.32713791940212
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	6/311	106/9376	1.70648546987806	CCND1/HSP90AA1/IL1R2/PDGFD/HSP90B1/FGFR1	1.35487187718451
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/311	156/9376	1.54604666501773	CCND1/STAT1/BAX/RSAD2/CLDN5/IRF7/OAS2/YWHAH	1.27382135732747
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/311	41/9376	2.20594463179358	CCND1/TYMP/CDKN2A	1.43332298166457
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	7/311	134/9376	1.57489081921582	ADM/RHOA/CALM1/EDN1/PRKCH/ADCY4/ACTG2	1.24147139911161
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/311	87/9376	1.73263850389918	CCND1/RAC2/TGFB1/BAX/RHOA	1.27158914738519
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/311	89/9376	1.69370280718234	GLUL/GNG11/GNAI2/ADCY4/SLC38A1	1.21790288991343
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	12/311	268/9376	1.3499064164707	UCHL1/NDUFA13/BAX/CALM1/SOD1/SLC25A4/BCL2L1/NDUFA4L2/COX7A1/UBA7/GNAI2/MAOA	1.07643973597879
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/311	116/9376	1.55937465350926	GAPDH/ENO1/ENO2/PFKP/TPI1/PGK1	1.12281501953099
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/311	68/9376	1.7734064686968	CCND1/ITGAM/JUP/DUSP6	1.18553941603747
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	3/311	46/9376	1.96616804138124	FTL/CP/FTH1	1.21666969409604
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	4/311	69/9376	1.74770492567221	RAC2/LCP2/FCER1G/ALOX5AP	1.15460081196464
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	6/311	119/9376	1.5200626874544	CCL5/IRF1/CCL2/CSF1/EDN1/BIRC3	1.05748927924907
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	8/311	170/9376	1.41872517495744	CCND1/WNT5A/GSTT1/TGFB1/BAX/CDKN2A/BCL2L1/TXNRD2	1.02046937698861
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/311	71/9376	1.69847380100539	CCND1/PRL/STAT1/IRF1	1.09421593467971
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/311	71/9376	1.69847380100539	SLC16A3/PFKP/SLC2A1/FGFR1	1.09421593467971
NA	NA	hsa03272	Virion - Hepatitis viruses	3/311	48/9376	1.88424437299035	CD9/CLDN5/DPP4	1.13757642518357
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	6/311	122/9376	1.48268409677929	CCND1/STAT1/PFKP/ATP2A3/SLC2A1/NOTCH1	0.993939811770901
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/311	73/9376	1.65194027221072	CCND1/BAX/CDKN2A/RARB	1.03571354880659
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/311	201/9376	1.3499064164707	IGFBP3/IL1R2/BAX/IL2RB/BCL2L1/ITGAM/JUP/DUSP6/BIRC3	0.928814159029816
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/311	99/9376	1.52262171554776	CCND1/BAX/CDKN2A/ADCY4/NOTCH1	0.968240397803636
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	5/311	101/9376	1.49247079048741	WNT5A/CALM1/EDN1/GNAI2/ADCY4	0.921650223825849
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/311	76/9376	1.58673210357082	CALM1/EZR/GNAI2/ADCY4	0.951233424263613
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/311	76/9376	1.58673210357082	CCND1/BAX/CALM1/CDKN2A	0.951233424263613
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	5/311	102/9376	1.477838723914	RHOA/ATP2A3/CPA3/RAP1A/ADCY4	0.898731183010923
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	7/311	157/9376	1.34417432977656	C1QA/C1QB/TGFB1/ATP2A3/SLC2A1/STAB1/ANO4	0.805505152144361
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	5/311	105/9376	1.4356147603736	STAT1/IRF1/RHOA/CALM1/FCER1G	0.831411207356759
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	4/311	80/9376	1.50739549839228	PDGFD/BAX/BCL2L1/KDR	0.844161369930402
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/311	109/9376	1.38293164990118	CCL5/STAT1/SPP1/IRF7/CCL4	0.744812332306529
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/311	110/9376	1.37035954399298	LEFTY2/TGFB1/RHOA/INHBB/BMP6	0.723695152873336
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/311	59/9376	1.53294457463622	TYMP/UPP1/CMPK2	0.760592313306775
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/311	59/9376	1.53294457463622	GSTT1/GGT5/LAP3	0.760592313306775
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/311	166/9376	1.27129740828265	PDE2A/RHOA/CALM1/ATP2A3/SLC25A4/GNAI2/ADCY4	0.653208462282733
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/311	139/9376	1.30134863170557	CTSD/HSP90AA1/HSP90B1/CALM1/GNAI2/ADCY4	0.662968784949436
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/311	35/9376	1.72273771244832	PFKP/TPI1	0.793414222842184
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/311	61/9376	1.48268409677929	FTL/FTH1/MT2A	0.700516560326432
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/311	12/9376	2.5123258306538	SLAMF1	0.970928432363127
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/311	116/9376	1.29947887792438	GLUL/GNG11/GNAI2/ADCY4/SLC38A1	0.601134463380221
Human Diseases	Substance dependence	hsa05032	Morphine addiction	4/311	91/9376	1.32518285572948	GNG11/PDE2A/GNAI2/ADCY4	0.577350187642541
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/311	38/9376	1.58673210357082	PNP/NNMT	0.671253624431282
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/311	65/9376	1.39144199851595	KISS1/SPP1/KCNN3	0.5865538146302
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/311	14/9376	2.1534221405604	B4GALT4	0.799926181829364
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/311	150/9376	1.20591639871383	CCND1/WNT5A/TGFB1/BAX/JUP/RARB	0.470881650602076
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/311	94/9376	1.28288978586577	HSP90AA1/CCL2/HSP90B1/CSF3	0.510554772489508
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/311	15/9376	2.00986066452304	AK4	0.724983114457799
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	4/311	97/9376	1.2432127821792	GNG11/CALM1/GNAI2/ADCY4	0.445967904088347
Organismal Systems	Endocrine system	hsa04924	Renin secretion	3/311	69/9376	1.31077869425416	CALM1/EDN1/GNAI2	0.479902325646132
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	6/311	155/9376	1.16701586972306	CCND1/WNT5A/CDKN2A/RAP1A/GNAI2/ADCY4	0.388343916320622
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/311	98/9376	1.23052693746309	PTPRC/RAC2/FCGR3A/ASAP1	0.424902672812634
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/311	16/9376	1.88424437299035	MAOA	0.655656393137
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/311	99/9376	1.21809737243821	CALM1/PRKCH/ADCY4/TRPV2	0.404060299002636
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/311	128/9376	1.17765273311897	PNP/PDE2A/AK4/ADCY4/AMPD3	0.374830477446945
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/311	158/9376	1.1448573405511	CCND1/TGFB1/CDC25B/CDKN2A/YWHAH/CCND3	0.340120358186066
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	3/311	72/9376	1.2561629153269	ISG15/IFIH1/IRF7	0.404137902439704
NA	NA	hsa04382	Cornified envelope formation	8/311	217/9376	1.11144368545053	S100A10/ITGB4/CLDN5/S100A1/JUP/LAMC2/KRT85/KRT86	0.30764030391253
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/311	17/9376	1.7734064686968	GGT5	0.591152411699554
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/311	17/9376	1.7734064686968	TXNRD2	0.591152411699554
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	5/311	133/9376	1.13338007397916	CCND1/TGFB1/KLF2/IL7R/TNFSF10	0.286940748218911
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/311	254/9376	1.06823303035674	SLN/PDGFD/CALM1/ATP2A3/CXCR4/SLC25A4/KDR/ADCY4/FGFR1	0.204196555735523
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/311	19/9376	1.58673210357082	HYAL2	0.474165842968198
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/311	226/9376	1.06718265372905	RAC2/RHOA/CALM1/ATP2A3/EDN1/RAP1A/GNAI2/ADCY4	0.189357606577848
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/311	78/9376	1.15953499876329	ENO1/ENO2/PFKP	0.262053782200956
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/311	78/9376	1.15953499876329	RHOA/CAV1/HCLS1	0.262053782200956
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/311	49/9376	1.23052693746309	GNAI2/MAOA	0.299661301111392
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/311	169/9376	1.07033999885843	CTSD/OPTN/VAMP8/BCL2L1/DDIT4/CTSL	0.170910429734612
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	2/311	50/9376	1.20591639871383	MAOA/LAP3	0.270402161777413
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/311	110/9376	1.09628763519439	HSP90AA1/CDC25B/GNAI2/ADCY4	0.188149315987748
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	3/311	82/9376	1.10297231589679	TYMP/GSTT1/UPP1	0.173463458457267
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/311	52/9376	1.15953499876329	BMP6/ADCY4	0.213667486509785
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	2/311	52/9376	1.15953499876329	LPL/TSPO	0.213667486509785
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/311	22/9376	1.37035954399298	MAOA	0.322120323682128
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	4/311	115/9376	1.04862295540333	RHOA/GNAI2/ADCY4/FGFR1	0.0971724738294189
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	10/311	300/9376	1.00493033226152	RAC2/TGFB1/PDGFD/CSF1/CDC25B/KDR/PTPN7/RAP1A/FGFR1/DUSP6	0.0160757594941576
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/311	23/9376	1.31077869425416	GLUL	0.276389548851941
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/311	178/9376	1.0162216843094	CCND1/WNT5A/RAC2/RHOA/SFRP2/CCND3	0.0404707425073033
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/311	86/9376	1.0516712779481	SLC2A1/ADCY4/KCNN3	0.0891605009465642
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/311	148/9376	1.01851047188668	CCND1/WNT5A/BAX/FGFR1/NOTCH1	0.0420413335723709
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	2/311	55/9376	1.09628763519439	ASAH1/SMPD1	0.132648560047552
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/311	149/9376	1.01167483113576	GNG11/NDUFA13/NDUFA4L2/GNAI2/ADCY4	0.0266069693950337
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/311	87/9376	1.03958310233951	ATP2A3/TPM3/COX7A1	0.0687016080739314
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/311	56/9376	1.0767110702802	ITGB2/ITGAM	0.10664144665991
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/311	89/9376	1.0162216843094	PDGFD/GNAI2/ADCY4	0.0284796832233286
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	4/311	122/9376	0.98845606451953	STAT1/IGFBP3/GNAI2/ADCY4	-0.0237711934888967
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	5/311	154/9376	0.978828245709275	CALM1/ATP2A3/TPM3/GNAI2/ADCY4	-0.0490666689066423
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/311	154/9376	0.978828245709275	CCND1/RHOA/CALM1/GNAI2/ADCY4	-0.0490666689066423
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/311	217/9376	0.972513224769215	CCND1/GSTT1/HSP90AA1/HSP90B1/GNAI2/ADCY4/CCND3	-0.0758772455468349
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/311	59/9376	1.02196304975748	GNAI2/ADCY4	0.0313445855673003
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/311	59/9376	1.02196304975748	CCND1/BAX	0.0313445855673003
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/311	60/9376	1.00493033226152	RAC2/KDR	0.00709608814809505
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	5/311	157/9376	0.96012452126897	TGFB1/NDUFA13/BAX/NDUFA4L2/COX7A1	-0.0933245183710246
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/311	28/9376	1.0767110702802	B4GALT4	0.0752938725259198
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/311	62/9376	0.972513224769215	SOD1/ADCY4	-0.0402192018269498
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/311	62/9376	0.972513224769215	LFNG/NOTCH1	-0.0402192018269498
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/311	63/9376	0.957076506915735	WNT5A/BAX	-0.0633143946691443
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/311	29/9376	1.03958310233951	CALM1	0.0395416361266911
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	15/311	480/9376	0.942122186495177	WNT5A/UCHL1/OPTN/CSF1/NDUFA13/BAX/CALM1/ATP2A3/SOD1/SLC25A4/BCL2L1/NDUFA4L2/COX7A1/UBA7/CYBB	-0.241111139832513
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/311	163/9376	0.924782514351094	STAT1/TGFB1/IFIH1/BAX/IRF7	-0.179429566119494
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/311	98/9376	0.922895203097316	PDE2A/CALM1/ADCY4	-0.142118030331582
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/311	133/9376	0.906704059183328	GNG11/CALM1/GNAI2/MAOA	-0.20070769392365
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/311	31/9376	0.972513224769215	PFKP	-0.0283920606218673
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/311	31/9376	0.972513224769215	GLUL	-0.0283920606218673
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/311	31/9376	0.972513224769215	SEC11C	-0.0283920606218673
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	2/311	67/9376	0.899937610980467	CALM1/RAP1A	-0.152243472894133
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/311	32/9376	0.942122186495177	PFKP	-0.0607438925784884
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	1/311	33/9376	0.913573029328656	VAMP8	-0.0921181091591941
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/311	69/9376	0.873852462836106	CALM1/MAOA	-0.194796160672376
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/311	105/9376	0.861368856224162	OPTN/CITED2/BCL2L1	-0.264590406727877
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/311	34/9376	0.886703234348402	BHLHE40	-0.122579816681263
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	3/311	107/9376	0.845268503771374	PFKP/CALM1/SLC2A1	-0.298150884023666
NA	NA	hsa04519	Cadherin signaling	12/311	404/9376	0.895482474292445	WNT5A/RAC2/RHOA/CYFIP2/KDR/MYO1G/JUP/MYO1F/FGFR1/YWHAH/KRT85/KRT86	-0.397756328778004
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/311	73/9376	0.82597013610536	GSTT1/MAOA	-0.276474848411244
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	4/311	144/9376	0.837441943551268	WNT5A/LEFTY2/INHBB/FGFR1	-0.364102595519678
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/311	37/9376	0.814808377509342	GLUL	-0.209051813545135
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/311	37/9376	0.814808377509342	MAOA	-0.209051813545135
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	2/311	75/9376	0.803944265809218	HSP90B1/ADCY4	-0.315738315020866
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	4/311	149/9376	0.809339864908608	PDGFD/RHOA/FCER1G/ADCY4	-0.434514925332946
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/311	78/9376	0.773023332508863	TPI1/IMPA2	-0.372834140774797
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/311	115/9376	0.786467216552495	GNG11/GNAI2/ADCY4	-0.426743060744837
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/311	115/9376	0.786467216552495	GNG11/GNAI2/MAOA	-0.426743060744837
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/311	253/9376	0.834131896343556	CCL5/BAX/RHOA/MYL12A/BCL2L1/HCLS1/TNIP1	-0.495377447573563
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	11/311	388/9376	0.854708787748202	GAPDH/WNT5A/CSF1/NDUFA13/CALM1/ATP2A3/SLC25A4/NDUFA4L2/COX7A1/CYBB/LPL	-0.541384237158194
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/311	41/9376	0.735314877264528	MAOA	-0.314590951623718
Genetic Information Processing	Translation	hsa03010	Ribosome	6/311	222/9376	0.814808377509342	MRPS6/RPS26/RPS27L/RPLP2/RPS21/RPL38	-0.517218795184374
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/311	42/9376	0.717807380186801	MAOA	-0.339483230998988
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	6/311	227/9376	0.796861056418828	GSTT1/NDUFA13/SOD1/SLC25A4/NDUFA4L2/COX7A1	-0.573853761736468
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/311	44/9376	0.685179771996492	MGAT1	-0.387689046384041
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/311	44/9376	0.685179771996492	ARHGDIB	-0.387689046384041
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/311	194/9376	0.777007988862002	TPM3/MYL12A/MYO1G/MYO1F/ACTG2	-0.581304190408783
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/311	45/9376	0.669953554841015	ABCA7	-0.411054256875425
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/311	46/9376	0.65538934712708	PSMB9	-0.433959021262732
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/311	47/9376	0.641444892932886	PRKCZ	-0.456424789215878
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	6/311	235/9376	0.769733871519464	NDUFA13/NDUFA4L2/COX7A1/ADCY4/FGFR1/COX14	-0.662138840985006
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	2/311	90/9376	0.669953554841015	BAX/ADCY4	-0.5827253387382
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/311	90/9376	0.669953554841015	SLC2A1/ADCY4	-0.5827253387382
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/311	91/9376	0.66259142786474	RAC2/PIK3AP1	-0.599056496989963
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/311	93/9376	0.648342149846143	CALM1/ADCY4	-0.631247315600427
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/311	93/9376	0.648342149846143	CALM1/ADCY4	-0.631247315600427
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/311	98/9376	0.615263468731544	IMPA2/CALM1	-0.709138733475797
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/311	138/9376	0.65538934712708	NDUFA13/NDUFA4L2/COX7A1	-0.755372537229669
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/311	138/9376	0.65538934712708	CALM1/ADCY4/YWHAH	-0.755372537229669
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/311	138/9376	0.65538934712708	CALM1/PRKCZ/PRKAR1B	-0.755372537229669
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/311	99/9376	0.609048686219104	RAC2/PDGFD	-0.724299898599364
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/311	56/9376	0.538355535140101	MGAT1	-0.641764394570115
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/311	56/9376	0.538355535140101	CCND1	-0.641764394570115
NA	NA	hsa04081	Hormone signaling	5/311	219/9376	0.688308446754467	PRL/GNG11/RHOA/GNAI2/ADCY4	-0.864474947640487
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	3/311	144/9376	0.628081457663451	CCND1/C1QA/C1QB	-0.833034729529636
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/311	144/9376	0.628081457663451	ATP2A3/RELN/SLC25A4	-0.833034729529636
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/311	60/9376	0.502465166130761	GNAI2	-0.716087851814295
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/311	370/9376	0.733327539758408	ADM/GZMA/PRL/F2RL3/RXFP1/KISS1/PGRMC2/EDN1/TSPO	-0.969382079411999
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/311	63/9376	0.478538253457868	GGT5	-0.769183317877107
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/311	109/9376	0.553172659960471	PRKCZ/SLC2A1	-0.869091163812264
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/311	191/9376	0.631369842258548	GNG11/CALM1/GNAI2/MAOA	-0.953344562563485
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/311	65/9376	0.463813999505318	LPL	-0.803444559178155
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/311	65/9376	0.463813999505318	ADCY4	-0.803444559178155
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/311	68/9376	0.443351617174201	CYP26B1	-0.853275251014496
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/311	158/9376	0.572428670275551	WNT5A/RHOA/DDIT4	-1.00392367596084
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/311	70/9376	0.430684428112081	SLC2A1	-0.885528385856599
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/311	70/9376	0.430684428112081	GSTT1	-0.885528385856599
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/311	71/9376	0.424618450251347	CCL5	-0.901381926350625
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	7/311	323/9376	0.653360277940928	CCND1/RHOA/CDC25B/CDKN2A/EZR/DDIT4/NOTCH1	-1.17426267668187
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/311	122/9376	0.494228032259765	CCND1/PFKP	-1.04148219874869
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/311	76/9376	0.396683025892706	LPL	-0.978121476059931
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/311	79/9376	0.381619113517034	GSTT1	-1.02230413208025
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	3/311	174/9376	0.519791551169753	HSP90AA1/BAX/HSP90B1	-1.18425502169392
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/311	83/9376	0.3632278309379	SOD1	-1.07926248139479
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/311	86/9376	0.350557092649368	ADCY4	-1.12063523982766
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	6/311	308/9376	0.587296947425565	NDUFA13/BAX/SOD1/SLC25A4/NDUFA4L2/COX7A1	-1.36407802372646
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/311	142/9376	0.424618450251347	UBA7/BIRC3	-1.27963790822794
NA	NA	hsa04082	Neuroactive ligand signaling	3/311	199/9376	0.454491105042899	GNG11/GNAI2/ADCY4	-1.44065482252094
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	7/311	368/9376	0.573465678736195	OPTN/NDUFA13/BAX/SOD1/BCL2L1/NDUFA4L2/COX7A1	-1.5461286638636
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/311	154/9376	0.39153129828371	CMPK2/AK4	-1.41015864425776
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/311	103/9376	0.292698155027628	PELO	-1.33688854435458
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/311	449/9376	0.134289131259892	PDE2A/CALM1	-3.48197141592019