category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Immune disease	hsa05330	Allograft rejection	5/52	39/9376	23.1163708086785	HLA-C/HLA-DRB5/HLA-DRB1/HLA-E/HLA-A	10.3354327271481
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/52	70/9376	15.4549450549451	HLA-C/HLA-DRB5/CCND1/HLA-DRB1/HLA-E/HLA-A	9.06504822228562
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	9/52	224/9376	7.24450549450549	HLA-C/HLA-DRB5/CCND1/HLA-DRB1/HLA-E/PIK3R1/HLA-A/IL1R2/SLC2A1	7.06399255923891
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/52	44/9376	20.4895104895105	HLA-C/HLA-DRB5/HLA-DRB1/HLA-E/HLA-A	9.67667337138242
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/52	45/9376	20.034188034188	HLA-C/HLA-DRB5/HLA-DRB1/HLA-E/HLA-A	9.55790468049103
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/52	82/9376	13.1932457786116	HLA-C/HLA-DRB5/HLA-DRB1/HSP90AA1/HLA-E/HLA-A	8.28153988181489
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	5/52	54/9376	16.6951566951567	HLA-C/HLA-DRB5/HLA-DRB1/HLA-E/HLA-A	8.63762139539665
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/52	157/9376	8.03919647231749	HLA-C/SERPINE1/IGFBP3/CCND1/HLA-E/PIK3R1/HLA-A	6.64228006685319
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	6/52	110/9376	9.83496503496503	SERPINE1/EGLN3/GAPDH/PIK3R1/PFKP/SLC2A1	6.96051233330914
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	7/52	180/9376	7.01196581196581	HLA-C/CCL5/HLA-DRB5/HLA-DRB1/HLA-E/PIK3R1/HLA-A	6.08190246449445
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/52	205/9376	6.15684803001876	HLA-C/HLA-DRB5/CCND1/HLA-DRB1/HLA-E/PIK3R1/HLA-A	5.57492583922665
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/52	100/9376	9.01538461538462	HLA-DRB5/CD9/HLA-DRB1/CSF3R/IL1R2	6.01769502805577
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	6/52	160/9376	6.76153846153846	HLA-C/HLA-DRB5/HLA-DRB1/HLA-E/NRCAM/HLA-A	5.48925493854651
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/52	106/9376	8.50507982583454	CCND1/HSP90AA1/PIK3R1/PDGFD/IL1R2	5.80302656957432
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	4/52	71/9376	10.1581798483207	PIK3R1/SLC16A3/PFKP/SLC2A1	5.78450673636623
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/52	37/9376	14.6195426195426	HBB/HBA1/HBA2	6.19868225549819
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	7/52	298/9376	4.23541559112029	CCL5/PRL/CCL21/CCL18/CSF3R/IL1R2/INHBB	4.23866695834597
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	4/52	88/9376	8.1958041958042	SERPINE1/CFH/CLU/SERPINF2	5.06460696140377
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	6/52	227/9376	4.76584208742799	HLA-C/CCL5/CCND1/HLA-E/PIK3R1/HLA-A	4.28918123441353
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	5/52	155/9376	5.81637717121588	HLA-C/HLA-DRB5/HLA-DRB1/HLA-E/HLA-A	4.51526771210949
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/52	50/9376	10.8184615384615	HBB/HBA1/HBA2	5.19836676506086
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	5/52	196/9376	4.59968602825746	HLA-C/CCND1/HLA-E/PIK3R1/HLA-A	3.80327295407054
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/52	122/9376	5.91172761664565	CCND1/PIK3R1/PFKP/SLC2A1	4.07789106495644
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/52	205/9376	4.39774859287054	HLA-C/CCND1/HLA-E/PIK3R1/HLA-A	3.67321206972257
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/52	133/9376	5.42278773857721	HLA-C/HLA-E/PIK3R1/HLA-A	3.8362033342967
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	3/52	70/9376	7.72747252747253	EGLN3/PIK3R1/SLC2A1	4.21896192921032
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/52	71/9376	7.61863488624052	PRL/CCND1/PIK3R1	4.18047458327946
Human Diseases	Cancer: specific types	hsa05218	Melanoma	3/52	73/9376	7.40990516332982	CCND1/PIK3R1/PDGFD	4.10570461856405
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/52	142/9376	5.07908992416035	HSP90AA1/GSTT1/PIK3R1/IL1R2	3.65762093254912
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/52	75/9376	7.21230769230769	GLUL/GAPDH/PFKP	4.03371253824633
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/52	75/9376	7.21230769230769	SERPINE1/IGFBP3/CCND1	4.03371253824633
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	6/52	333/9376	3.24878724878725	HLA-C/WNT5A/CCND1/HLA-E/PIK3R1/HLA-A	3.12032908311459
Human Diseases	Immune disease	hsa05310	Asthma	2/52	32/9376	11.2692307692308	HLA-DRB5/HLA-DRB1	4.34542906890177
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	4/52	168/9376	4.29304029304029	PRL/CCND1/CSF3R/PIK3R1	3.21629005480235
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	4/52	170/9376	4.24253393665158	WNT5A/CCND1/GSTT1/PIK3R1	3.18610205824365
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	6/52	362/9376	2.98852528686783	PRL/CCND1/HSP90AA1/CSF3R/PIK3R1/PDGFD	2.88146138574995
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/52	173/9376	4.16896398399289	CCL5/HLA-DRB5/HLA-DRB1/PIK3R1	3.14167908990389
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/52	95/9376	5.69392712550607	CCL5/HLA-DRB5/HLA-DRB1	3.43389440934156
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/52	99/9376	5.46386946386946	HLA-DRB5/CFH/HLA-DRB1	3.33435228648693
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/52	100/9376	5.40923076923077	CCL5/CCL21/CCL18	3.31030977934891
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	3/52	101/9376	5.35567402894136	SERPINE1/CCND1/PIK3R1	3.28658808005741
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/52	103/9376	5.25168035847648	SERPINE1/CCL5/PIK3R1	3.2400765193439
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/52	103/9376	5.25168035847648	PIK3R1/IL1R2/HSPB1	3.2400765193439
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	4/52	193/9376	3.736946990833	CCL5/CCL21/CCL18/PIK3R1	2.86905534507272
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	3/52	109/9376	4.96259703599153	HLA-DRB5/HLA-DRB1/HSP90AA1	3.1074901120519
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	4/52	205/9376	3.51819887429644	GAPDH/CTSD/PIK3R1/SLC2A1	2.72235518497053
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	3/52	122/9376	4.43379571248424	CCND1/PIK3R1/PFKP	2.85085940176544
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/52	214/9376	3.37023723939612	HLA-C/HLA-E/PIK3R1/HLA-A	2.61932710875675
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/52	50/9376	7.21230769230769	HLA-DRB5/HLA-DRB1	3.28909511082979
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	4/52	217/9376	3.32364409783765	CCND1/HSP90AA1/GSTT1/PIK3R1	2.58619712677767
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/52	139/9376	3.89153292750415	HSP90AA1/CTSD/PIK3R1	2.56481620001755
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/52	59/9376	6.11212516297262	CCND1/PIK3R1	2.94154579498905
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/52	60/9376	6.01025641025641	PIK3R1/HSPB1	2.90741492287958
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/52	144/9376	3.75641025641026	WNT5A/PIK3R1/INHBB	2.48922058022165
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	4/52	248/9376	2.90818858560794	S100A10/PODXL/HSP90AA1/GAPDH	2.27428818903234
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	3/52	148/9376	3.65488565488566	WNT5A/CCND1/PIK3R1	2.43113493022525
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	3/52	150/9376	3.60615384615385	WNT5A/CCND1/PIK3R1	2.40284153984506
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/52	66/9376	5.46386946386946	HLA-DRB5/HLA-DRB1	2.71765792716455
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/52	67/9376	5.38231917336395	GAPDH/PFKP	2.68828970406195
NA	NA	hsa04518	Integrin signaling	3/52	154/9376	3.51248751248751	CCND1/PIK3R1/PDGFD	2.34767454446118
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/52	68/9376	5.30316742081448	CCND1/PIK3R1	2.65950425742824
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/52	157/9376	3.4453699167075	WNT5A/SERPINE1/CCND1	2.30748380411111
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/52	73/9376	4.93993677555321	CCND1/PIK3R1	2.52362807312362
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/52	75/9376	4.80820512820513	GSTT1/PIK3R1	2.47270507751504
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/52	76/9376	4.74493927125506	CCND1/PIK3R1	2.44791469220924
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/52	77/9376	4.68331668331668	CCND1/PIK3R1	2.42355274789538
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	2/52	77/9376	4.68331668331668	CCND1/PIK3R1	2.42355274789538
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	2/52	78/9376	4.6232741617357	HLA-DRB5/HLA-DRB1	2.39960581106765
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/52	80/9376	4.50769230769231	PIK3R1/PDGFD	2.35290614478872
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/52	181/9376	2.98852528686783	HLA-DRB5/HLA-DRB1/CTSD	2.0173475084315
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/52	184/9376	2.93979933110368	WNT5A/PIK3R1/SEMA3A	1.98448073175191
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/52	87/9376	4.14500442086649	CCND1/PIK3R1	2.20081016215107
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/52	17/9376	10.606334841629	GLUL	2.96042208296711
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/52	93/9376	3.87758478081059	HLA-DRB5/HLA-DRB1	2.08262752784784
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/52	93/9376	3.87758478081059	CCND1/PIK3R1	2.08262752784784
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	3/52	203/9376	2.66464569912846	CCND1/PIK3R1/PDGFD	1.79060714388655
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	2/52	98/9376	3.67974882260597	PIK3R1/IMPA2	1.99143492859022
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	3/52	204/9376	2.65158371040724	WNT5A/CCND1/PIK3R1	1.78102423480647
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	2/52	99/9376	3.64257964257964	CCND1/PIK3R1	1.97391333791854
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/52	99/9376	3.64257964257964	PIK3R1/PDGFD	1.97391333791854
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	3/52	216/9376	2.5042735042735	CCL5/HSP90AA1/PIK3R1	1.67029092840289
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/52	107/9376	3.37023723939612	PFKP/SLC2A1	1.84142248768591
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/52	23/9376	7.83946488294314	GLUL	2.45243074730321
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/52	109/9376	3.30839802399435	CCL5/PIK3R1	1.81025826474119
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	2/52	109/9376	3.30839802399435	PIK3R1/SLC2A1	1.81025826474119
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/52	110/9376	3.27832167832168	HSP90AA1/PIK3R1	1.79494611223058
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	2/52	112/9376	3.21978021978022	HLA-DRB5/HLA-DRB1	1.76484225288963
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/52	116/9376	3.10875331564987	GAPDH/PFKP	1.70661460250216
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/52	116/9376	3.10875331564987	THY1/PIK3R1	1.70661460250216
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	3/52	232/9376	2.3315649867374	RGCC/PIK3R1/PDGFD	1.53364353526227
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/52	119/9376	3.03038138332256	CCL5/PIK3R1	1.6645703292523
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/52	122/9376	2.95586380832283	IGFBP3/PIK3R1	1.62382773857444
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	2/52	125/9376	2.88492307692308	CTSD/PIK3R1	1.58431113698335
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/52	31/9376	5.81637717121588	PFKP	2.00584726619147
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/52	31/9376	5.81637717121588	GLUL	2.00584726619147
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	3/52	250/9376	2.16369230769231	HLA-C/HLA-E/HLA-A	1.3926888969348
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/52	130/9376	2.77396449704142	PIK3R1/RXFP1	1.52098815914348
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/52	32/9376	5.63461538461539	PFKP	1.96113933633956
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/52	133/9376	2.71139386928861	CCND1/PIK3R1	1.48441554415901
Human Diseases	Infectious disease: viral	hsa05162	Measles	2/52	136/9376	2.65158371040724	CCND1/PIK3R1	1.4488393639382
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	2/52	137/9376	2.63222908478383	CTSD/PIK3R1	1.43719298895721
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/52	35/9376	5.15164835164835	PFKP	1.83757077430382
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	2/52	140/9376	2.57582417582418	SERPINE1/CCND1	1.4028653622735
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/52	37/9376	4.87318087318087	GLUL	1.7628064481748
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/52	37/9376	4.87318087318087	CCND1	1.7628064481748
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/52	143/9376	2.52178590640129	HLA-DRB5/HLA-DRB1	1.36941895913344
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/52	38/9376	4.74493927125506	PNP	1.7274115559134
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/52	38/9376	4.74493927125506	PIK3R1	1.7274115559134
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	2/52	149/9376	2.42023748064017	PIK3R1/PDGFD	1.30499852607976
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/52	41/9376	4.39774859287054	CCND1	1.62821662979724
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/52	42/9376	4.29304029304029	SAT1	1.59725394410283
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/52	155/9376	2.32655086848635	WNT5A/CCND1	1.24361778407714
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	2/52	156/9376	2.31163708086785	CCND1/PIK3R1	1.23366346198777
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/52	158/9376	2.2823758519961	WNT5A/PIK3R1	1.21398047136807
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	1/52	47/9376	3.83633387888707	PIK3R1	1.45571015785513
NA	NA	hsa03272	Virion - Hepatitis viruses	1/52	48/9376	3.75641025641026	CD9	1.42973775197868
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/52	48/9376	3.75641025641026	PIK3R1	1.42973775197868
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/52	168/9376	2.14652014652015	GLUL/HSP90AA1	1.11979842842396
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	2/52	169/9376	2.13381884387802	CTSD/PIK3R1	1.11074439127481
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/52	170/9376	2.12126696832579	CCND1/SYNPO	1.10175284682218
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/52	50/9376	3.60615384615385	SAT1	1.37982345659873
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	2/52	178/9376	2.02592912705272	WNT5A/CCND1	1.03196943889216
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/52	56/9376	3.21978021978022	CCND1	1.24417712428132
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	2/52	187/9376	1.92842451665981	CCL5/HSP90AA1	0.957677877639323
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/52	59/9376	3.05606258148631	GSTT1	1.18307006342712
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	1/52	59/9376	3.05606258148631	PIK3R1	1.18307006342712
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	1/52	62/9376	2.90818858560794	PIK3R1	1.12573248655416
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/52	63/9376	2.86202686202686	WNT5A	1.10738233860455
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/52	65/9376	2.77396449704142	PIK3R1	1.07174043562267
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	2/52	201/9376	1.79410639112132	IGFBP3/IL1R2	0.84988440687654
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/52	68/9376	2.65158371040724	CYP26B1	1.02073507251452
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/52	69/9376	2.61315496098105	PIK3R1	1.00434276198923
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/52	70/9376	2.57582417582418	SLC2A1	0.988237733826789
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/52	70/9376	2.57582417582418	GSTT1	0.988237733826789
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/52	71/9376	2.53954496208017	CCL5	0.972410277105928
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	2/52	212/9376	1.70101596516691	PIK3R1/PDGFD	0.770973546086289
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/52	73/9376	2.46996838777661	GSTT1	0.941551527683191
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/52	370/9376	1.46195426195426	ADM/PRL/RXFP1	0.67704891514581
NA	NA	hsa04081	Hormone signaling	2/52	219/9376	1.64664559185107	PRL/PIK3R1	0.723099313592481
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/52	78/9376	2.31163708086785	IMPA2	0.86866514118671
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/52	78/9376	2.31163708086785	PFKP	0.86866514118671
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	1/52	78/9376	2.31163708086785	PIK3R1	0.86866514118671
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/52	79/9376	2.2823758519961	GSTT1	0.854758915016531
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	2/52	227/9376	1.58861402914266	GSTT1/PIK3R1	0.67041373204142
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	3/52	388/9376	1.39413164155432	WNT5A/GAPDH/PIK3R1	0.592122836178564
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/52	82/9376	2.19887429643527	GSTT1	0.814264345973183
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/52	83/9376	2.17238183503244	CCL5	0.801154609977422
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/52	85/9376	2.12126696832579	PNP	0.775485066029731
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/52	86/9376	2.09660107334526	PIK3R1	0.762915103679097
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/52	86/9376	2.09660107334526	SLC2A1	0.762915103679097
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	2/52	238/9376	1.51519069166128	PIK3R1/PDGFD	0.601197390633409
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/52	89/9376	2.02592912705272	PDGFD	0.726207647672915
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	1/52	89/9376	2.02592912705272	GLUL	0.726207647672915
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/52	90/9376	2.0034188034188	PIK3R1	0.714291246253456
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/52	90/9376	2.0034188034188	SLC2A1	0.714291246253456
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/52	90/9376	2.0034188034188	PIK3R1	0.714291246253456
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/52	91/9376	1.98140321217244	PIK3R1	0.70252760632731
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	1/52	94/9376	1.91816693944354	HSP90AA1	0.668114617031044
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	2/52	253/9376	1.42535725144421	CCL5/PIK3R1	0.512190408897076
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	1/52	98/9376	1.83987441130298	PIK3R1	0.624146272288088
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/52	99/9376	1.82128982128982	PIK3R1	0.613474389350162
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/52	101/9376	1.78522467631379	WNT5A	0.592493846920648
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/52	105/9376	1.71721611721612	CCL21	0.551909128145841
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/52	105/9376	1.71721611721612	CITED2	0.551909128145841
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	1/52	105/9376	1.71721611721612	PIK3R1	0.551909128145841
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	2/52	275/9376	1.31132867132867	CCL5/PIK3R1	0.391315531431749
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/52	110/9376	1.63916083916084	INHBB	0.503554556960943
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	1/52	115/9376	1.56789297658863	PIK3R1	0.457585920611311
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	1/52	116/9376	1.55437665782493	GLUL	0.448657172230127
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	1/52	120/9376	1.5025641025641	PIK3R1	0.413767706389804
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/52	122/9376	1.47793190416141	PIK3R1	0.396796075383438
NA	NA	hsa04517	IgSF CAM signaling	2/52	299/9376	1.20607152045279	PIK3R1/NRCAM	0.270438538016135
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	2/52	300/9376	1.20205128205128	PDGFD/HSPB1	0.265620244306924
Organismal Systems	Immune system	hsa04611	Platelet activation	1/52	126/9376	1.43101343101343	PIK3R1	0.363740272156987
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/52	128/9376	1.40865384615385	PNP	0.347634477899892
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	1/52	134/9376	1.34557979334099	ADM	0.300887354081181
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	1/52	138/9376	1.30657748049052	PIK3R1	0.270942411960027
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	1/52	138/9376	1.30657748049052	PIK3R1	0.270942411960027
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	2/52	323/9376	1.11645629911884	CCND1/PIK3R1	0.15905750401024
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/52	142/9376	1.26977248104009	PIK3R1	0.241898436176556
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/52	144/9376	1.25213675213675	CCND1	0.227696146097794
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/52	144/9376	1.25213675213675	PIK3R1	0.227696146097794
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/52	154/9376	1.17082917082917	CCND1	0.159623199643285
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/52	157/9376	1.1484566389025	SLC2A1	0.140085672740065
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/52	157/9376	1.1484566389025	PIK3R1	0.140085672740065
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/52	158/9376	1.14118792599805	CCND1	0.133657682876515
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	1/52	163/9376	1.10618216139689	PIK3R1	0.102124749816442
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1/52	174/9376	1.03625110521662	HSP90AA1	0.0360446604791652
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/52	195/9376	0.92465483234714	PIK3R1	-0.0793987916676479
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	1/52	200/9376	0.901538461538462	GAPDH	-0.105109287053741
NA	NA	hsa04382	Cornified envelope formation	1/52	217/9376	0.830911024459412	S100A10	-0.18819466506071
Genetic Information Processing	Translation	hsa03010	Ribosome	1/52	222/9376	0.812196812196812	MRPS6	-0.211475553612548
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	1/52	226/9376	0.797821647379169	PIK3R1	-0.229754752544782
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	1/52	233/9376	0.773852756685375	ANKRD1	-0.261042413656146
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	1/52	238/9376	0.75759534583064	PIK3R1	-0.282872047035795
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	2/52	480/9376	0.751282051282051	WNT5A/UCHL1	-0.417750074870961
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/52	250/9376	0.721230769230769	CTSD	-0.333626689746941
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	1/52	254/9376	0.709872804360993	PDGFD	-0.350063186826279
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/52	268/9376	0.672789896670494	UCHL1	-0.405853007557256
NA	NA	hsa04519	Cadherin signaling	1/52	404/9376	0.446306169078446	WNT5A	-0.849575368344282