category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/161	100/9376	7.57068322981367	CD9/CSF1/CSF3R/HLA-DRB1/ITGA5/HLA-DRB5/CD7/CD59/HLA-DPA1/CD3D/CD2/ITGA1/CD34	8.73134335584265
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/161	233/9376	4.74886039506305	ANKRD1/COL27A1/ENO1/NID2/COL1A1/ITGA5/COL5A1/ENO2/ITGAV/SUN2/SDC4/PDLIM4/PDLIM5/ITGA1/JUP/HSPG2/FLNC/PLEC/ITGB5	7.65920643412311
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	15/161	204/9376	4.28206065034709	CCND1/LUM/COL1A1/ITGA5/ITGAV/FGFR1/SDC4/TGFB1/TWIST1/TWIST2/WNT5A/HSPG2/ITGB5/EZR/RHOA	6.26441570093125
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	15/161	205/9376	4.26117254961369	STAT1/CCND1/HLA-C/STAT2/HLA-DRB1/HLA-DRB5/ISG15/OAS1/CD247/HLA-DPA1/CD3D/CCND3/BAX/ADRM1/PSMD2	6.24012469687348
NA	NA	hsa04518	Integrin signaling	12/161	154/9376	4.53787206582238	CCND1/COL1A1/ITGA5/ITGAV/PDGFD/CCND3/RAC2/TGFB1/LAMB2/ITGA1/ITGB5/TNC	5.85114461471215
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	19/161	362/9376	3.05658693936378	CCND1/HSP90AA1/HSP90B1/CSF1/CSF3R/COL1A1/ITGA5/IL2RG/ITGAV/FGFR1/CSH1/PDGFD/CCND3/LAMB2/ITGA1/MCL1/ITGB5/TNC/TEK	5.27464806891825
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	18/161	333/9376	3.14789323484976	STAT1/CCND1/HLA-C/STAT2/COL1A1/ITGA5/MX2/ITGAV/ISG15/CCND3/BAX/LAMB2/ITGA1/WNT5A/ATP6V0B/NOTCH1/ITGB5/TNC	5.27508482839293
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/161	160/9376	4.36770186335404	NFASC/HLA-C/HLA-DRB1/HLA-DRB5/ITGAV/SLITRK4/NEGR1/HLA-DPA1/SDC4/CD2/CD34/PTPRC	5.67901874182958
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/161	89/9376	5.88903622025263	COL1A1/ITGA5/ITGAV/SDC4/LAMB2/ITGA1/HSPG2/ITGB5/TNC	6.12535751134384
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/161	95/9376	5.51709709055247	CCL5/CSF1/HLA-DRB1/HLA-DRB5/HLA-DPA1/TGFB1/LTB/ATP6V0B/TEK	5.84890743340388
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	12/161	173/9376	4.03949305281298	STAT1/CCL5/STAT2/HLA-DRB1/HLA-DRB5/MX2/OAS1/HLA-DPA1/ADAR/CCND3/RSAD2/BAX	5.33347669892196
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	9/161	109/9376	4.80847911561912	STAT1/HSP90AA1/HLA-DRB1/HLA-DRB5/IL2RG/CD247/HLA-DPA1/CD3D/TGFB1	5.28623118398717
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/161	136/9376	4.28206065034709	STAT1/CCND1/STAT2/IL2RG/MX2/OAS1/CD3D/ADAR/CCND3/BAX	5.09601828105833
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	8/161	93/9376	5.00955052427703	STAT1/HLA-DRB1/HLA-DRB5/IL2RG/CD247/HLA-DPA1/CD3D/NOTCH1	5.13622329078799
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	12/161	203/9376	3.44252363614111	CCND1/COL1A1/ITGA5/ITGAV/PDGFD/CCND3/RAC2/LAMB2/ITGA1/ITGB5/TNC/RHOA	4.65031105793589
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/161	180/9376	3.55886818495514	STAT1/CCL5/HLA-C/STAT2/HLA-DRB1/BST2/ITGA5/HLA-DRB5/OAS1/HLA-DPA1/BAX	4.58179434983697
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	12/161	232/9376	3.01220818162347	RGCC/ITGA5/ITGAV/FGFR1/BAIAP2/PDGFD/RAC2/ITGA1/CXCR4/ITGB5/EZR/RHOA	4.10203820284983
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	6/161	66/9376	5.29418407679277	STAT1/HLA-DRB1/HLA-DRB5/IL2RG/HLA-DPA1/TGFB1	4.62731101760251
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	10/161	181/9376	3.2174599361724	STAT1/CTSD/HLA-DRB1/HLA-DRB5/SPHK1/HLA-DPA1/TGFB1/BAX/ATP6V0B/RHOA	3.98171443017823
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	6/161	70/9376	4.99165927240461	CCND1/HLA-C/HLA-DRB1/HLA-DRB5/HLA-DPA1/RAC2	4.43069510304306
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/161	155/9376	3.381446603887	HLA-C/HLA-DRB1/ITGA5/HLA-DRB5/ITGAV/SEC61A1/HLA-DPA1/ATP6V0B/ITGB5	3.95156011140059
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/161	50/9376	5.82360248447205	HLA-DRB1/HLA-DRB5/HLA-DPA1/TGFB1/CXCR4	4.52022146444565
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/161	50/9376	5.82360248447205	HBB/HBA2/HBA1/TGFB1/GYPC	4.52022146444565
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	11/161	224/9376	2.85980479148181	CCND1/HLA-C/HLA-DRB1/HLA-DRB5/IL2RG/TSPO/HLA-DPA1/CD3D/CCND3/TGFB1/BAX	3.72378220436967
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	6/161	82/9376	4.26117254961369	HSP90AA1/HLA-C/HLA-DRB1/HLA-DRB5/HLA-DPA1/HSPA2	3.92039906209157
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/161	142/9376	3.28090280815327	HSP90AA1/HSP90B1/KLF2/ITGAV/GSTT1/SDC4/RAC2/RHOA	3.61998627070127
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	10/161	214/9376	2.7213095721832	SAMHD1/HLA-C/TNFRSF1B/BST2/CD247/CD3D/RAC2/BAX/AP1M1/CXCR4	3.36683344963199
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/161	39/9376	5.97292562509954	HLA-C/HLA-DRB1/HLA-DRB5/HLA-DPA1	4.11331050338058
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/161	184/9376	2.84850121523089	SEMA3C/RAC2/ABLIM3/WNT5A/CXCR4/NTN4/DPYSL2/SEMA3A/RHOA	3.34714518422572
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	8/161	156/9376	2.98646281254977	STAT1/CCND1/STAT2/MX2/OAS1/IFIT1/RSAD2/BAX	3.30695423216745
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	7/161	125/9376	3.26121739130435	CTSD/SPHK1/RAC2/BAX/ASAH1/SMPD1/RHOA	3.3639837518768
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/161	44/9376	5.29418407679277	HLA-C/HLA-DRB1/HLA-DRB5/HLA-DPA1	3.77372750142126
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/161	45/9376	5.17653554175293	HLA-C/HLA-DRB1/HLA-DRB5/HLA-DPA1	3.71201096273497
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/161	100/9376	3.49416149068323	CCL5/CSF1/TNFRSF1B/IL2RG/CCL18/CXCR4	3.31432510111939
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	5/161	73/9376	3.98876882498086	SAMHD1/BST2/MX2/MDFIC/CXCR4	3.38838812150419
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/161	168/9376	2.77314404022479	STAT1/CCND1/CSF3R/STAT2/IL2RG/CSH1/CCND3/MCL1	3.06525711133833
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	5/161	77/9376	3.78156005485198	STAT1/CCND1/RAC2/TGFB1/BAX	3.23941497964321
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	5/161	78/9376	3.73307851568721	STAT1/HLA-DRB1/HLA-DRB5/HLA-DPA1/TGFB1	3.20372732288422
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	6/161	112/9376	3.11978704525288	STAT1/HLA-DRB1/HLA-DRB5/HLA-DPA1/TGFB1/LAMB2	2.98299742374556
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/161	298/9376	2.14965192379841	CCL5/CSF1/CSF3R/TNFRSF1B/IL2RG/CCL18/CSH1/TGFB1/IL32/LTB/CXCR4	2.66581691726909
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/161	54/9376	4.31377961812744	HLA-C/HLA-DRB1/HLA-DRB5/HLA-DPA1	3.2278761239953
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/161	86/9376	3.38581539794887	ITGA5/ITGAV/ITGA1/JUP/ITGB5	2.93784657921844
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	5/161	87/9376	3.34689797958164	CCND1/RAC2/TGFB1/BAX/RHOA	2.90683420806686
Human Diseases	Immune disease	hsa05310	Asthma	3/161	32/9376	5.45962732919255	HLA-DRB1/HLA-DRB5/HLA-DPA1	3.34008907498172
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/161	193/9376	2.41392849097287	STAT1/CCL5/STAT2/CCL18/RAC2/RASGRP2/CXCR4/RHOA	2.62340120977317
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/161	37/9376	4.72183985227463	HBB/HBA2/HBA1	2.99819076853924
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/161	38/9376	4.59758090879372	IL2RG/CD3D/PTPRC	2.93715144311519
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/161	99/9376	2.94121337599598	ITGA5/ITGAV/TGFB1/ITGA1/ITGB5	2.56648068764337
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	5/161	101/9376	2.88297152696636	STAT1/CCND1/COL1A1/TGFB1/BAX	2.51477067376809
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/161	138/9376	2.53200108020524	SKAP2/ITGA5/BAIAP2/WIPF1/RAC2/RHOA	2.39640679411091
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/161	105/9376	2.77314404022479	ITGA5/ITGAV/TGFB1/ITGA1/ITGB5	2.4150508647441
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	5/161	106/9376	2.74698230399625	CCND1/HSP90AA1/HSP90B1/FGFR1/PDGFD	2.39085081556323
Human Diseases	Cancer: specific types	hsa05218	Melanoma	4/161	73/9376	3.19101505998468	CCND1/FGFR1/PDGFD/BAX	2.48396909832478
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/161	75/9376	3.10592132505176	CCND1/CCND3/BAX/PPP1R13L	2.42024236261584
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	8/161	227/9376	2.05237091963773	CCND1/CCL5/HLA-C/ITGAV/RAC2/BAX/CXCR4/RHOA	2.1215137939937
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	7/161	187/9376	2.17995814926761	STAT1/HSP90AA1/CCL5/STAT2/OAS1/NAMPT/RHOA	2.15429011148503
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/161	55/9376	3.17651044607566	SPHK1/ASAH1/SMPD1	2.13974368378351
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/161	170/9376	2.05538911216661	CCND1/TXNRD2/GSTT1/TGFB1/BAX/WNT5A	1.83549198047527
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	7/161	212/9376	1.92288761279737	CSF1/FGFR1/PDGFD/RAC2/RASGRP2/RHOA/TEK	1.79649127980064
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	4/161	93/9376	2.50477526213852	FGFR1/BAIAP2/RAC2/RHOA	1.92761300849078
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	4/161	93/9376	2.50477526213852	CCND1/ITGAV/BAX/LAMB2	1.92761300849078
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	6/161	174/9376	2.00813878774898	HSP90AA1/HSP90B1/RRBP1/RPN2/SEC61A1/BAX	1.77420884695501
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/161	59/9376	2.96115380566375	GSTT1/GGT5/LAP3	1.99733319340005
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/161	98/9376	2.37698060590696	SPHK1/RAC2/MARCKS/PTPRC	1.81119238546125
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	4/161	99/9376	2.35297070079679	CFH/HLA-DRB1/HLA-DRB5/HLA-DPA1	1.78876429427068
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	5/161	142/9376	2.05056425509579	STAT1/CSF1/STAT2/TGFB1/FOSB	1.66733460379901
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/161	31/9376	3.75716289320777	SEC61A1/TMEM208	2.03237818883832
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/161	103/9376	2.26159319785322	COL27A1/COL1A1/COL5A1/COL8A1	1.70168326411563
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/161	103/9376	2.26159319785322	CCL5/CD247/CD3D/TGFB1	1.70168326411563
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	8/161	275/9376	1.69413890457369	CCL5/NDUFA13/NDUFS8/RAC2/BAX/NOTCH1/ADRM1/PSMD2	1.54425523500101
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/161	323/9376	1.62267561486837	CCND1/ITGA5/MARCKS/CDC25B/NOTCH1/MCL1/EZR/TNC/RHOA	1.50528164396855
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/161	148/9376	1.9674332717811	CCND1/FGFR1/BAX/WNT5A/NOTCH1	1.56801058713187
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	7/161	238/9376	1.71282426013884	CSF1/FGFR1/PDGFD/RAC2/RASGRP2/RHOA/TEK	1.47229989153111
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	7/161	238/9376	1.71282426013884	STAT1/STAT2/MX2/ISG15/OAS1/ADAR/RPS27L	1.47229989153111
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	5/161	150/9376	1.94120082815735	CCND1/TGFB1/BAX/JUP/WNT5A	1.53593243421192
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/161	110/9376	2.11767363071711	ENO1/ENO2/TIMP1/TEK	1.55853337130525
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/161	196/9376	1.78273545443022	STAT1/CCND1/HLA-C/STAT2/BAX/MICA	1.46376920912055
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/161	37/9376	3.14789323484976	CCND1/BAX	1.73027156571466
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/161	38/9376	3.06505393919582	NNMT/NAMPT	1.68595962436698
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/161	116/9376	2.00813878774898	RAC2/CXCR4/EZR/RHOA	1.44409156774055
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	7/161	250/9376	1.63060869565217	CTSD/LAPTM5/AP1M1/ASAH1/SMPD1/ATP6V0B/CTSA	1.33579752244198
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	6/161	205/9376	1.70446901984548	CTSD/COL1A1/NDUFA13/NDUFS8/RAC2/TGFB1	1.34797360827803
NA	NA	hsa04517	IgSF CAM signaling	8/161	299/9376	1.55815451089553	NFASC/ITGA5/FGFR1/SLITRK4/BAIAP2/CD2/EZR/RHOA	1.29649179267611
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	8/161	300/9376	1.55296066252588	CSF1/FGFR1/PDGFD/RAC2/TGFB1/RASGRP2/CDC25B/TEK	1.28664437891898
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/161	77/9376	2.26893603291119	CCND1/TGFB1/BAX	1.47780752964555
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/161	163/9376	1.78638113020615	STAT1/STAT2/TGFB1/BAX/HSPG2	1.33868148497219
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	4/161	120/9376	1.94120082815735	ARHGDIB/BAX/RHOA/MATK	1.37155161899798
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	2/161	41/9376	2.84078169974246	TYMP/CCND1	1.56130575945635
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	4/161	122/9376	1.90937786376133	CD247/CD3D/PTPRC/RHOA	1.33631995139386
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/161	122/9376	1.90937786376133	STAT1/CCND1/ITGAV/NOTCH1	1.33631995139386
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/161	10/9376	5.82360248447205	TST	2.01718318787304
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/161	168/9376	1.73321502514049	STAT1/HSP90AA1/STAT2/BAX/SMPD1	1.26751832844166
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/161	216/9376	1.61766735679779	HSP90AA1/CCL5/HSP90B1/BAX/HSPA2/RHOA	1.2139049853763
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/161	83/9376	2.10491656065255	CCL5/SAMHD1/ADAR	1.33641538589566
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/161	44/9376	2.64709203839639	RPN2/MGAT1	1.44746392132095
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/161	46/9376	2.53200108020524	ADRM1/PSMD2	1.37672776764393
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/161	178/9376	1.63584339451462	CCND1/CCND3/RAC2/WNT5A/RHOA	1.13204676747669
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	4/161	133/9376	1.75145939382618	HLA-C/CD247/RAC2/MICA	1.15365451009039
NA	NA	hsa03272	Virion - Hepatitis viruses	2/161	48/9376	2.42650103519669	CD9/HSPG2	1.30963220909749
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/161	90/9376	1.94120082815735	STAT1/CD247/CD3D	1.18587830002166
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/161	49/9376	2.37698060590696	FUT11/GALNT15	1.27733785056629
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/161	51/9376	2.28376568018512	SEC61A1/ATP6V0B	1.21505891279257
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/161	94/9376	1.85859653759746	HSP90AA1/HSP90B1/FOSB	1.10581680094327
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/161	99/9376	1.76472802559759	CCND1/BAX/NOTCH1	1.011047900898
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/161	56/9376	2.07985803016859	RPN2/MGAT1	1.07128155135373
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/161	56/9376	2.07985803016859	CCND1/GAS1	1.07128155135373
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	6/161	248/9376	1.40893608495292	S100A10/HSP90AA1/HSP90B1/BAX/PTPRC/RHOA	0.862669345717359
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/161	17/9376	3.42564852027768	GGT5	1.32308734252028
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/161	17/9376	3.42564852027768	TXNRD2	1.32308734252028
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/161	250/9376	1.39766459627329	HLA-C/IL2RG/WIPF1/RAB11FIP1/CXCR4/RHOA	0.842359748806488
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	3/161	103/9376	1.69619489838992	COL1A1/TGFB1/LAMB2	0.93905326151785
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	5/161	200/9376	1.45590062111801	BAIAP2/WIPF1/BAX/EZR/RHOA	0.861408961817163
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/161	59/9376	1.97410253710917	CCND1/BAX	0.992072791804746
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	3/161	105/9376	1.66388642413487	STAT1/STAT2/RHOA	0.90422404854122
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	2/161	60/9376	1.94120082815735	SPHK1/RAC2	0.966705283751057
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	5/161	205/9376	1.42039084987123	CCND1/HLA-C/CCND3/BAX/RHOA	0.804401265100753
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/161	61/9376	1.90937786376133	MT2A/SLC26A6	0.941821873678788
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	4/161	157/9376	1.48372037820944	ITGAV/SPHK1/TGFB1/ITGB5	0.807891816371803
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	4/161	157/9376	1.48372037820944	CCND1/HLA-C/CCND3/TGFB1	0.807891816371803
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/161	157/9376	1.48372037820944	CCND1/CCND3/TGFB1/WNT5A	0.807891816371803
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/161	157/9376	1.48372037820944	NDUFA13/NDUFS8/TGFB1/BAX	0.807891816371803
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	4/161	158/9376	1.47432974290432	CCND1/CCND3/TGFB1/CDC25B	0.794769982581582
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/161	109/9376	1.60282637187304	STAT1/CCL5/STAT2	0.836732844997386
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/161	110/9376	1.58825522303783	LEFTY2/TGFB1/RHOA	0.820289009915027
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/161	63/9376	1.84876269348319	PTGES/GGT5	0.893434383286222
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/161	63/9376	1.84876269348319	BAX/WNT5A	0.893434383286222
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	6/161	268/9376	1.3037916010012	NDUFA13/NDUFS8/BAX/UCHL1/ADRM1/PSMD2	0.66693353470282
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	5/161	217/9376	1.34184389043135	CCND1/HSP90AA1/HSP90B1/GSTT1/CCND3	0.673417760706
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/161	67/9376	1.73838880133494	ENO1/ENO2	0.801718479316812
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/161	116/9376	1.50610409081174	ENO1/ENO2/H6PD	0.724960351512836
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	2/161	68/9376	1.71282426013884	CCND1/JUP	0.779757655867297
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/161	23/9376	2.53200108020524	CTSA	0.972295842635281
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	3/161	119/9376	1.468135080119	CCL5/CSF1/TNFRSF1B	0.67929816568096
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	2/161	71/9376	1.64045140407663	STAT1/CCND1	0.715991842289312
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	2/161	71/9376	1.64045140407663	CCL5/ATP6V0B	0.715991842289312
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	2/161	71/9376	1.64045140407663	SLC16A3/FGFR1	0.715991842289312
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/161	72/9376	1.61766735679779	ISG15/ADAR	0.695403630436206
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/161	73/9376	1.59550752999234	CCND1/BAX	0.675131051965947
Organismal Systems	Immune system	hsa04611	Platelet activation	3/161	126/9376	1.38657202011239	COL1A1/RASGRP2/RHOA	0.577425194677907
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/161	75/9376	1.55296066252588	ENO1/ENO2	0.635493265766879
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/161	75/9376	1.55296066252588	GSTT1/BAX	0.635493265766879
Human Diseases	Cancer: specific types	hsa05214	Glioma	2/161	76/9376	1.53252696959791	CCND1/BAX	0.616109401046019
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	2/161	78/9376	1.49323140627488	ENO1/ENO2	0.578168143987672
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/161	78/9376	1.49323140627488	ITGA5/RHOA	0.578168143987672
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/161	78/9376	1.49323140627488	ITGA5/RHOA	0.578168143987672
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	2/161	80/9376	1.45590062111801	PDGFD/BAX	0.541275071796002
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	3/161	133/9376	1.31359454536964	CCND1/KLF2/TGFB1	0.481436208766202
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/161	134/9376	1.3037916010012	CALD1/ADM/RHOA	0.468161920674201
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/161	82/9376	1.42039084987123	TYMP/GSTT1	0.505370344093654
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/161	31/9376	1.87858144660389	H6PD	0.647625779961924
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/161	137/9376	1.27524141995738	CTSD/BAX/MCL1	0.428955752352128
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/161	138/9376	1.26600054010262	NDUFA13/NDUFS8/ATP6V0B	0.416086848616119
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/161	32/9376	1.81987577639752	BAX	0.614055373116416
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	3/161	139/9376	1.25689262254792	HSP90AA1/CTSD/HSP90B1	0.403315086016917
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/161	140/9376	1.24791481810115	CCND1/KLF2/SPHK1	0.390638863606006
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	6/161	308/9376	1.13446801645559	NDUFA13/NDUFS8/BAX/ADRM1/PSMD2/POLR2J3	0.317168105134734
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	9/161	480/9376	1.09192546583851	CSF1/TNFRSF1B/NDUFA13/NDUFS8/BAX/WNT5A/UCHL1/ADRM1/PSMD2	0.273281339275569
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/161	34/9376	1.71282426013884	POLR2J3	0.550367658665789
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	1/161	34/9376	1.71282426013884	BHLHE40	0.550367658665789
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/161	143/9376	1.22173478695218	HLA-DRB1/HLA-DRB5/HLA-DPA1	0.353167995423258
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/161	88/9376	1.32354601919819	CFH/CD59	0.403057679221266
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/161	144/9376	1.21325051759834	FGFR1/LEFTY2/WNT5A	0.340858672705928
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/161	36/9376	1.61766735679779	GALNT15	0.490776058660924
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/161	149/9376	1.17253741298095	SPHK1/PDGFD/RHOA	0.280606070615343
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/161	41/9376	1.42039084987123	BABAM1	0.356565178379669
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/161	99/9376	1.17648535039839	PDGFD/RAC2	0.233331507525316
NA	NA	hsa04382	Cornified envelope formation	4/161	217/9376	1.07347511234508	S100A10/KRT85/JUP/PLEC	0.144742810996592
NA	NA	hsa04081	Hormone signaling	4/161	219/9376	1.06367168666156	ITGAV/CSH1/VIPR2/RHOA	0.126020938985774
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/161	44/9376	1.32354601919819	TAF13	0.284332131270793
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/161	44/9376	1.32354601919819	ARHGDIB	0.284332131270793
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	2/161	105/9376	1.10925761608991	LTB/PPP1R13L	0.148810640439778
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/161	45/9376	1.29413388543823	ABCA8	0.261419589596094
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	4/161	227/9376	1.02618545981886	NDUFA13/GSTT1/NDUFS8/SLC26A6	0.0527882452575848
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	3/161	170/9376	1.0276945560833	CCND1/EZR/RHOA	0.0481653022640814
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	2/161	110/9376	1.05883681535855	HSP90AA1/CDC25B	0.0820446485248088
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/161	49/9376	1.18849030295348	FOSB	0.174850537033239
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/161	50/9376	1.16472049689441	LAP3	0.154360382741564
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	2/161	115/9376	1.0128004320821	FGFR1/RHOA	0.0182555748976668
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/161	52/9376	1.11992355470616	TSPO	0.114618821553915
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/161	54/9376	1.07844490453186	TST	0.0764113681556681
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	6/161	368/9376	0.949500405076965	TNFRSF1B/NDUFA13/NDUFS8/BAX/ADRM1/PSMD2	-0.130631682809874
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/161	370/9376	0.944367970454927	GZMA/ADM/TSPO/CSH1/TAC3/VIPR2	-0.144314743280082
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	2/161	122/9376	0.954688931880664	STAT1/CSH1	-0.0665840755089315
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	4/161	253/9376	0.920727665529178	CCL5/ITGA5/BAX/RHOA	-0.168952249063639
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	4/161	254/9376	0.917102753460165	FGFR1/SPHK1/PDGFD/CXCR4	-0.177036508689462
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/161	59/9376	0.987051268554585	TYMP	-0.0131876097905527
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	2/161	130/9376	0.895938843764931	COL1A1/TGFB1	-0.157918963600199
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/161	62/9376	0.939290723301943	NOTCH1	-0.0633918889447121
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	6/161	388/9376	0.900557085227637	CSF1/NDUFA13/NDUFS8/WNT5A/ADRM1/PSMD2	-0.264429000105551
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/161	63/9376	0.924381346741595	POLR2J3	-0.0795985796237114
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/161	68/9376	0.856412130069419	DHRS3	-0.157070609305919
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	1/161	69/9376	0.844000360068413	RAC2	-0.171907249140189
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/161	69/9376	0.844000360068413	FOSB	-0.171907249140189
NA	NA	hsa04519	Cadherin signaling	6/161	404/9376	0.864891458089908	FGFR1/KRT85/RAC2/JUP/WNT5A/RHOA	-0.366927079026373
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	1/161	70/9376	0.831943212067436	TNFRSF1B	-0.186541068891734
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/161	70/9376	0.831943212067436	GSTT1	-0.186541068891734
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/161	70/9376	0.831943212067436	TGFB1	-0.186541068891734
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	2/161	144/9376	0.808833678398896	ADRM1/PSMD2	-0.305559392684602
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/161	73/9376	0.797753764996171	GSTT1	-0.229287971213467
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/161	75/9376	0.77648033126294	HSP90B1	-0.256881282657602
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	2/161	149/9376	0.781691608653966	NDUFA13/NDUFS8	-0.35504566122555
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/161	76/9376	0.766263484798954	EZR	-0.270422481122101
Genetic Information Processing	Translation	hsa03010	Ribosome	3/161	222/9376	0.786973308712439	RPS27L/MRPL27/MRPL20	-0.424576508800391
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/161	78/9376	0.746615703137442	IMPA2	-0.297018248977845
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	2/161	154/9376	0.756312010970396	CCND1/RHOA	-0.403025784469446
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/161	79/9376	0.737164871452158	GSTT1	-0.310081920986747
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/161	79/9376	0.737164871452158	ATP6V0B	-0.310081920986747
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/161	155/9376	0.751432578641555	CCND1/WNT5A	-0.412450611166566
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/161	226/9376	0.773044577584785	RAC2/VIPR2/RHOA	-0.456494072156522
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	2/161	158/9376	0.737164871452158	WNT5A/RHOA	-0.440397157594932
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	1/161	85/9376	0.685129704055535	TYMP	-0.385443593489563
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	3/161	235/9376	0.743438615038985	NDUFA13/FGFR1/NDUFS8	-0.52647684403701
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/161	89/9376	0.654337357805848	PDGFD	-0.43307252521142
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/161	90/9376	0.647066942719117	BAX	-0.444682624014574
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/161	91/9376	0.639956316974951	RAC2	-0.456179583316842
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/161	98/9376	0.59424515147674	IMPA2	-0.533704025210482
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/161	101/9376	0.576594305393272	WNT5A	-0.565472291351557
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/161	102/9376	0.570941420046279	RHOA	-0.57588270720813
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/161	105/9376	0.554628808044957	CITED2	-0.606602767661663
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	2/161	201/9376	0.579462933778313	BAX/JUP	-0.796618117422494
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/161	115/9376	0.506400216041048	KCND2	-0.703956535821843
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/161	117/9376	0.497743802091628	MBD2	-0.722581935388574
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/161	122/9376	0.477344465940332	CCND1	-0.768036088960327
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/161	144/9376	0.404416839199448	CCND1	-0.951977458075133
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/161	154/9376	0.378156005485198	DHRS3	-1.02844282438761
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	1/161	166/9376	0.350819426775425	RHOA	-1.11542570967943
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	1/161	169/9376	0.344591862986512	CTSD	-1.13644132051007
Human Diseases	Substance dependence	hsa05034	Alcoholism	1/161	191/9376	0.30490065363728	FOSB	-1.28284707961785
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/161	195/9376	0.298646281254977	RAC2	-1.30815836453041
NA	NA	hsa04082	Neuroactive ligand signaling	1/161	199/9376	0.292643340928244	TAC3	-1.33310858474478