category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	24/191	238/9376	4.95015178846408	C1QB/C1QA/RPL36A/RPL39/RPS27L/RPS26/MX2/OAS2/IFIH1/RPL28/EIF2AK2/RPL9/RPLP2/RPS10/C1R/RPL35/RPLP1/RPS12/RPL23A/RELA/IRF3/RPS11/MAPK3/NFKB1	8.90101283569022
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	20/191	180/9376	5.4543339150669	CCL5/HLA-C/HLA-DRB1/HLA-DRA/BCL2L1/HLA-DRB5/OAS2/IFIH1/TAPBP/IRF7/TNFRSF14/EIF2AK2/BIRC3/TAP1/RELA/IRF3/ZC3HAV1/HLA-DPA1/BAX/NFKB1	8.7012627503957
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	16/191	112/9376	7.01271503365744	HLA-DRB1/HLA-DRA/BCL2L1/HLA-DRB5/LAMB2/LAMC2/GNAI2/TGFB2/LDLR/BIRC3/RELA/ITGA6/HLA-DPA1/MAPK3/NFKB1/LAMC1	9.230879910799
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	18/191	173/9376	5.10752655630542	CCL5/HLA-DRB1/HLA-DRA/HLA-DRB5/MX2/OAS2/RSAD2/IFIH1/TNFSF10/IRF7/EIF2AK2/RELA/IRF3/KPNA2/HLA-DPA1/BAX/MAPK3/NFKB1	7.86323874527769
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	16/191	156/9376	5.03476976775406	CCND1/CFLAR/MX2/OAS2/CD81/RSAD2/IRF7/EIF2AK2/LDLR/RELA/CTNNB1/IRF3/YWHAG/BAX/MAPK3/NFKB1	7.32787982099855
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	18/191	205/9376	4.31025411824799	HLA-C/CCND1/HLA-DRB1/HLA-DRA/HLA-DRB5/OAS2/TAPBP/IRF7/MDM2/GADD45B/EIF2AK2/RAC1/TAP1/RELA/IRF3/HLA-DPA1/BAX/NFKB1	6.9102325009143
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	11/191	77/9376	7.01271503365744	CCND1/BCL2L1/TGFB2/GADD45B/RAC1/RALBP1/CDKN2A/RELA/BAX/MAPK3/NFKB1	7.63942376979105
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	14/191	137/9376	5.01639469560897	CTSS/CFLAR/CTSD/BCL2L1/TNFSF10/GADD45B/BIRC3/ITPR3/PRF1/RELA/CTSW/BAX/MAPK3/NFKB1	6.82883982807309
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	11/191	82/9376	6.58511045843443	HLA-C/HSP90AA1/CTSS/HLA-DRB1/HLA-DRA/PSME2/HLA-DRB5/TAPBP/TAP1/KLRC1/HLA-DPA1	7.32487301890401
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/191	70/9376	7.01271503365744	HLA-C/CCND1/HLA-DRB1/HLA-DRA/HLA-DRB5/CD55/RAC1/CAV1/PRF1/HLA-DPA1	7.28116476546142
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	11/191	93/9376	5.80622642571638	CCND1/BCL2L1/LAMB2/LAMC2/GADD45B/BIRC3/RELA/ITGA6/BAX/NFKB1/LAMC1	6.71682862160726
NA	NA	hsa04518	Integrin signaling	14/191	154/9376	4.46263683960019	ITGB4/CCND1/LAMB2/LAMC2/FLNA/RAC1/TNXB/LIMS2/PARVB/CTNNB1/ITGAX/ITGA6/ACTN4/LAMC1	6.24766145566158
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/191	77/9376	6.37519548514313	CCND1/BCL2L1/MDM2/TGFB2/GADD45B/CDKN2A/RELA/BAX/MAPK3/NFKB1	6.82942662784033
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	17/191	227/9376	3.67626911456051	CCL5/HLA-C/CCND1/TAPBP/GNAI2/MDM2/RAC1/CDKN2A/ITPR3/TAP1/PPP3R1/RELA/CTNNB1/IRF3/BAX/MAPK3/NFKB1	5.88597805348064
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	16/191	203/9376	3.86908415650066	ITGB4/CCND1/LAMB2/LAMC2/FLNA/RAC1/BIRC3/TNXB/CAV1/RAP1A/PARVB/CTNNB1/ITGA6/ACTN4/MAPK3/LAMC1	5.95934256433975
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/191	78/9376	6.29346220969258	C1QB/C1QA/GNAI2/IRF1/C1R/RELA/IRF3/CFL2/MAPK3/NFKB1	6.76947656171817
Human Diseases	Infectious disease: viral	hsa05162	Measles	13/191	136/9376	4.69233138281491	CCND1/BCL2L1/MX2/OAS2/IFIH1/IL2RG/IRF7/EIF2AK2/RELA/IRF3/BAX/CSNK2B/NFKB1	6.25456170782884
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	15/191	181/9376	4.06814960516039	CTSS/HLA-DRB1/HLA-DRA/CTSD/HLA-DRB5/FCER1G/TGFB2/FCGR3A/PPP3R1/RELA/ITGAX/HLA-DPA1/BAX/MAPK3/NFKB1	6.01039057008116
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	11/191	100/9376	5.39979057591623	HLA-DRB1/HLA-DRA/HLA-DRB5/CD9/CD7/CD59/CD55/CD2/CD34/ITGA6/HLA-DPA1	6.37843856154376
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	15/191	187/9376	3.9376207408237	CCL5/HSP90AA1/BCL2L1/OAS2/GBP4/IRF7/BIRC3/ITPR3/PKN1/CASP4/RELA/IRF3/MAP1LC3A/MAPK3/NFKB1	5.85120271944279
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/191	224/9376	3.50635751682872	HLA-C/CCND1/HLA-DRB1/HLA-DRA/DLG1/BCL2L1/HLA-DRB5/IL2RG/TGFB2/CDKN2A/PPP3R1/RELA/HLA-DPA1/BAX/MAPK3/NFKB1	5.47484420927681
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	20/191	333/9376	2.94828860273886	ITGB4/HLA-C/CCND1/DLG1/MX2/LAMB2/LAMC2/PRKCZ/IRF1/MDM2/EIF2AK2/TNXB/RELA/CTNNB1/IRF3/ITGA6/BAX/MAPK3/NFKB1/LAMC1	5.22013678117468
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	15/191	205/9376	3.59187843187332	HLA-C/CCND1/DLG1/IRF7/MDM2/EIF2AK2/RAC1/CDKN2A/RELA/IRF3/YWHAG/ACTN4/BAX/MAPK3/NFKB1	5.41060653912252
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	9/191	75/9376	5.89068062827225	CCND1/PERP/BCL2L1/MDM2/PPP1R13L/GADD45B/CDKN2A/ZMAT3/BAX	6.13193940290753
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	9/191	78/9376	5.66411598872332	HLA-DRB1/HLA-DRA/HLA-DRB5/TGFB2/FCGR3A/RELA/HLA-DPA1/MAPK3/NFKB1	5.96464518231276
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	15/191	214/9376	3.4408181239908	HLA-C/BCL2L1/TAPBP/GNAI2/RAC1/SAMHD1/ITPR3/TAP1/PPP3R1/RELA/IRF3/BAX/CFL2/MAPK3/NFKB1	5.20846684428673
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	7/191	45/9376	7.63606748109366	HLA-C/HLA-DRB1/HLA-DRA/HLA-DRB5/PRF1/KLRC1/HLA-DPA1	6.43451321745621
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/191	216/9376	3.40895869691681	CCL5/HSP90AA1/BCL2L1/TNFSF10/IRF7/RAC1/LDLR/SOD2/RAP1A/PPP3R1/RELA/IRF3/BAX/MAPK3/NFKB1	5.16501080114771
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/191	196/9376	3.50635751682872	HLA-C/CCND1/IRF7/EIF2AK2/RAC1/ITPR3/PPP3R1/RELA/CTNNB1/IRF3/BAX/MAP1LC3A/MAPK3/NFKB1	5.11343167283369
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/191	66/9376	5.95018245280025	HLA-DRB1/HLA-DRA/HLA-DRB5/IL2RG/TGFB2/RELA/HLA-DPA1/NFKB1	5.81943839596416
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	10/191	109/9376	4.50357846198184	HSP90AA1/HLA-DRB1/HLA-DRA/HLA-DRB5/IL2RG/PPP3R1/RELA/HLA-DPA1/MAPK3/NFKB1	5.3054015122606
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/191	133/9376	4.05999291422273	HLA-C/FCER1G/TNFSF10/TYROBP/RAC1/PRF1/FCGR3A/PPP3R1/KLRC1/MAPK3/HCST	5.12510191891664
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	12/191	157/9376	3.75202587788041	HLA-C/CCND1/MDM2/TGFB2/GADD45B/CDKN2A/ITPR3/PPP3R1/RELA/RRAS2/MAPK3/NFKB1	5.0144484796529
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	9/191	93/9376	4.75054889376794	HLA-DRB1/HLA-DRA/HLA-DRB5/IL2RG/PPP3R1/RELA/HLA-DPA1/MAPK3/NFKB1	5.24149133332667
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/191	39/9376	7.55215465163109	HLA-C/HLA-DRB1/HLA-DRA/HLA-DRB5/PRF1/HLA-DPA1	5.91255924132263
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/191	41/9376	7.18375686374665	TYMP/CCND1/MDM2/CDKN2A/RASSF1/MAPK3	5.72202715025971
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/191	101/9376	4.37426779327147	CCND1/EDN1/PRKCZ/TGFB2/RAC1/RELA/BAX/MAPK3/NFKB1	4.91638648280821
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	9/191	103/9376	4.28933055456717	C1QB/CCL5/C1QA/CFLAR/GNAI2/TGFB2/RELA/MAPK3/NFKB1	4.84037203519564
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/191	44/9376	6.69395525940029	HLA-C/HLA-DRB1/HLA-DRA/HLA-DRB5/PRF1/HLA-DPA1	5.45903357040256
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	9/191	105/9376	4.20762902019447	CFLAR/BCL2L1/PPP1R13L/GADD45B/BIRC3/RELA/CSNK2B/LTB/NFKB1	4.7662655424655
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	9/191	105/9376	4.20762902019447	FCER1G/IRF1/MDM2/ITPR3/PPP3R1/RELA/RRAS2/MAPK3/NFKB1	4.7662655424655
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/191	88/9376	4.46263683960019	C1QB/C1QA/F2RL3/CD59/CD55/C1R/ITGAX/CLU	4.70597829154393
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	18/191	362/9376	2.44088976309624	ITGB4/HSP90AA1/CCND1/BCL2L1/LAMB2/LAMC2/IL2RG/MDM2/RAC1/TNXB/TEK/PKN1/RELA/YWHAG/ITGA6/MAPK3/NFKB1/LAMC1	4.03170740010142
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/191	160/9376	3.37486910994764	HLA-C/HLA-DRB1/HLA-DRA/HLA-DRB5/L1CAM/CD2/SDC4/CD34/ITGA6/HLA-DPA1/PTPRF	4.3690918861248
Human Diseases	Immune disease	hsa05310	Asthma	5/191	32/9376	7.67015706806283	HLA-DRB1/HLA-DRA/HLA-DRB5/FCER1G/HLA-DPA1	5.45013646368179
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	8/191	89/9376	4.41249485263839	ITGB4/LAMB2/LAMC2/SDC4/TNXB/AGRN/ITGA6/LAMC1	4.66435962073274
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	15/191	275/9376	2.67758210376011	C1QB/CCL5/C1QA/NDUFA13/RAC1/COX7A1/CAV1/ITPR3/NDUFS5/PPP3R1/BAX/CSNK2B/MAPK3/LAMC1/SOD1	4.07163009473936
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/191	50/9376	5.89068062827225	HBA2/HBB/HBA1/GYPC/CD81/TGFB2	4.99999236900904
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	14/191	248/9376	2.77115352136463	HSP90AA1/TNFSF10/FLNA/RAC1/BIRC3/GAPDH/ELMO1/PKN1/CASP4/RELA/CTNNB1/BAX/MAPK3/NFKB1	4.07621397063705
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	8/191	93/9376	4.22271012779373	HEG1/RAC1/RAP1A/CTNNB1/ACTN4/CSNK2B/PTPRF/MAPK3	4.50382268918637
Genetic Information Processing	Translation	hsa03010	Ribosome	13/191	222/9376	2.87458138767039	RPL36A/RPL39/RPS27L/RPS26/RPL28/RPL9/RPLP2/RPS10/RPL35/RPLP1/RPS12/RPL23A/RPS11	4.07603660335326
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	10/191	142/9376	3.45697219969029	JUND/TGFB2/TYROBP/RAC1/ITPR3/FCGR3A/PPP3R1/RELA/MAPK3/NFKB1	4.25414434000843
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/191	142/9376	3.45697219969029	HSP90AA1/KLF2/EDN1/PRKCZ/RAC1/SDC4/CAV1/RELA/CTNNB1/NFKB1	4.25414434000843
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	14/191	253/9376	2.71638764149577	CCL5/BCL2L1/MDM2/RAC1/ITPR3/ELMO1/CASP4/RELA/IRF3/ACTN4/BAX/MAP1LC3A/MAPK3/NFKB1	3.99088803248754
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/191	95/9376	4.1338109672086	CCL5/HLA-DRB1/HLA-DRA/HLA-DRB5/TGFB2/TEK/HLA-DPA1/LTB	4.42690246852856
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/191	54/9376	5.4543339150669	HLA-C/HLA-DRB1/HLA-DRA/HLA-DRB5/PRF1/HLA-DPA1	4.73355952213573
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/191	37/9376	6.63364935616245	CCND1/GADD45B/CTNNB1/BAX/MAPK3	4.95111744614578
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/191	99/9376	3.96678830186684	C1QB/C1QA/HLA-DRB1/HLA-DRA/HLA-DRB5/C1R/FCGR3A/HLA-DPA1	4.27920525692561
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	9/191	125/9376	3.53440837696335	CTSD/FCER1G/PRKCZ/GNAI2/RAC1/RELA/BAX/MAPK3/NFKB1	4.11339108909832
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	10/191	155/9376	3.1670325958453	HLA-C/CTSS/HLA-DRB1/HLA-DRA/HLA-DRB5/RAC1/C1R/TAP1/FCGR3A/HLA-DPA1	3.92288000096821
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	10/191	157/9376	3.12668823156701	CCND1/DLG1/PRKCZ/TGFB2/BIRC3/BMP6/FRMD6/CTNNB1/RASSF1/YWHAG	3.87502481542447
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/191	87/9376	3.94969007642775	CCND1/TGFB2/GADD45B/RAC1/CTNNB1/BAX/MAPK3	3.98578871752765
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	9/191	143/9376	3.0895178120309	C1QB/C1QA/HLA-DRB1/HLA-DRA/HLA-DRB5/C1R/FCGR3A/HLA-DPA1/ACTN4	3.63082586083907
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	8/191	119/9376	3.30010119230938	CCL5/CFLAR/EDN1/IRF1/BIRC3/RELA/MAPK3/NFKB1	3.64122933950486
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	11/191	204/9376	2.64695616466482	CCND1/FLNA/MDM2/TGFB2/RAC1/SDC4/CAV1/ITPR3/CTNNB1/RRAS2/MAPK3	3.42947658748049
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/191	73/9376	4.03471275909058	CCND1/MDM2/GADD45B/CDKN2A/BAX/MAPK3	3.7534466875631
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/191	73/9376	4.03471275909058	CCND1/GADD45B/CDKN2A/RASSF1/BAX/MAPK3	3.7534466875631
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/191	75/9376	3.92712041884817	BCL2L1/MDM2/BIRC3/CDKN2A/BAX/MAPK3	3.67002599385255
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/191	155/9376	2.85032933626077	CCND1/GNAI2/KMT2A/LDLR/CDKN2A/ITPR3/RAP1A/CTNNB1/MAPK3	3.34956657428162
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/191	76/9376	3.87544778175806	CCND1/MDM2/GADD45B/CDKN2A/BAX/MAPK3	3.62938925020474
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	7/191	103/9376	3.33614598688558	LAMB2/LAMC2/TGFB2/RELA/ACTN4/NFKB1/LAMC1	3.43772555462837
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	8/191	133/9376	2.95272211943471	CCND1/KLF2/TNFSF10/MDM2/TGFB2/GADD45B/SOD2/MAPK3	3.27056309016582
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/191	106/9376	3.24172676084165	HSP90AA1/CCND1/MDM2/RELA/CTNNB1/MAPK3/NFKB1	3.34702135538666
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	10/191	193/9376	2.54347177386539	CCL5/CCL18/PRKCZ/GNAI2/RAC1/ELMO1/RAP1A/RELA/MAPK3/NFKB1	3.12426451084886
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/191	109/9376	3.15250492338729	CCL5/IRF7/RAC1/RELA/IRF3/MAPK3/NFKB1	3.25949682577609
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/191	83/9376	3.54860278811581	CCL5/IRF7/SAMHD1/RELA/IRF3/NFKB1	3.36299307476389
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/191	59/9376	4.1600851894578	CCND1/GADD45B/CTNNB1/BAX/MAPK3	3.51115086242843
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/191	110/9376	3.12384578772013	ENO1/EDN1/GAPDH/TEK/RELA/MAPK3/NFKB1	3.23099224488513
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/191	170/9376	2.59882968894364	CCND1/BCL2L1/TXNRD2/TGFB2/GADD45B/CDKN2A/CTNNB1/BAX/MAPK3	3.03356930338598
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	13/191	300/9376	2.12719022687609	JUND/FLNA/TGFB2/GADD45B/RAC1/TEK/PTPN7/RAP1A/PPP3R1/RELA/RRAS2/MAPK3/NFKB1	2.86136552246896
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	10/191	205/9376	2.39458562124888	NDUFA13/CTSD/PRKCZ/TGFB2/RAC1/COX7A1/GAPDH/NDUFS5/RELA/NFKB1	2.91122993613623
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/191	91/9376	3.2366377078419	CD81/RAC1/PPP3R1/RELA/MAPK3/NFKB1	3.0916343653361
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/191	120/9376	2.86352530541012	ARHGDIB/RAC1/RAP1A/RELA/BAX/MAPK3/NFKB1	2.96262706571971
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	10/191	212/9376	2.31551911488689	F2RL3/PRKCZ/GNAI2/RAC1/EVL/TEK/RAP1A/SIPA1/CTNNB1/MAPK3	2.79373555269276
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/191	184/9376	2.40109264739358	NTN4/PRKCZ/GNAI2/L1CAM/DPYSL2/RAC1/PPP3R1/CFL2/MAPK3	2.76779231518985
NA	NA	hsa04382	Cornified envelope formation	10/191	217/9376	2.2621661398895	ITGB4/S100A6/S100A4/PPL/LAMC2/KRT7/UGCG/ELOVL1/DST/ITGA6	2.7125959193965
Organismal Systems	Immune system	hsa04611	Platelet activation	7/191	126/9376	2.72716695753345	F2RL3/FCER1G/PRKCZ/GNAI2/ITPR3/RAP1A/MAPK3	2.81456620429052
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/191	71/9376	3.45697219969029	CCND1/IRF1/RELA/MAPK3/NFKB1	2.99663584168166
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/191	72/9376	3.40895869691681	IFIH1/IRF7/RELA/IRF3/NFKB1	2.95885370406229
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/191	100/9376	2.94534031413613	CCL5/CCL18/ACKR3/IL2RG/TNFSF10/TNFRSF14	2.82018733867295
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	8/191	163/9376	2.4092763305817	IFIH1/IRF7/TGFB2/RELA/IRF3/BAX/MAPK3/NFKB1	2.61729192911105
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	17/191	480/9376	1.73856893542757	OPTN/NDUFA13/BCL2L1/UBE2L6/RAC1/COX7A1/ITPR3/NDUFS5/PPP3R1/RELA/CTNNB1/BAX/CSNK2B/MAP1LC3A/MAPK3/NFKB1/SOD1	2.39539429086284
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/191	50/9376	3.92712041884817	HLA-DRB1/HLA-DRA/HLA-DRB5/HLA-DPA1	2.99254456993274
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	6/191	105/9376	2.80508601346298	OPTN/BCL2L1/RELA/RRAS2/CSNK2B/MAP1LC3A	2.68220520920259
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	10/191	233/9376	2.10682425903872	ANKRD1/ITGB4/ENO1/SYNE2/SUN2/SYNE1/SDC4/AGRN/INF2/ITGA6	2.46703329890071
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	5/191	78/9376	3.14673110484629	CLTB/RAC1/CAV1/ELMO1/CTNNB1	2.74531966469111
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	7/191	138/9376	2.49002200470445	RAC1/ELMO1/PKN1/RELA/IRF3/MAPK3/NFKB1	2.5427636120996
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	10/191	238/9376	2.06256324519337	BCL2L1/RAC1/RALBP1/TEK/RAP1A/RELA/RASSF1/RRAS2/MAPK3/NFKB1	2.39431029253594
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/191	140/9376	2.4544502617801	CCND1/KLF2/GNAI2/ITPR3/RRAS2/MAP1LC3A/MAPK3	2.50025135534737
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/191	32/9376	4.6020942408377	BCL2L1/BIRC3/BAX	2.94324480927243
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	14/191	388/9376	1.77125276623307	NDUFA13/SLC39A14/RTN4/EIF2AK2/COX7A1/GAPDH/ITPR3/NDUFS5/PPP3R1/RELA/CTNNB1/CSNK2B/MAPK3/NFKB1	2.23740089331636
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	7/191	144/9376	2.38627108784177	C1QB/C1QA/CCND1/RELA/CTNNB1/IRF3/NFKB1	2.41737627407211
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	6/191	116/9376	2.53908647770356	GNAI2/RAC1/RAP1A/SIPA1/CTNNB1/ACTN4	2.40518931200383
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/191	90/9376	2.72716695753345	PPP3R1/RELA/CSNK2B/MAPK3/NFKB1	2.37412716597186
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/191	37/9376	3.98018961369747	HBA2/HBB/HBA1	2.61913155334379
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/191	298/9376	1.81201026037457	CCL5/CCL18/IL32/ACKR3/IL2RG/TNFRSF18/TNFSF10/TNFRSF14/TGFB2/BMP6/LTB	2.05417434657503
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/191	157/9376	2.18868176209691	NDUFA13/RAC1/COX7A1/NDUFS5/RELA/BAX/NFKB1	2.16588931908183
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/191	227/9376	1.94626011947321	NDUFA13/RAC1/COX7A1/SOD2/NDUFS5/RELA/MAPK3/NFKB1/SOD1	2.08113087947731
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	5/191	94/9376	2.61111729976607	HSP90AA1/JUND/RELA/MAPK3/NFKB1	2.26377389390323
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/191	268/9376	1.8316792998359	NDUFA13/BCL2L1/SLC39A14/UBE2L6/GNAI2/COX7A1/ITPR3/NDUFS5/BAX/SOD1	1.99193205149446
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/191	67/9376	2.93068687973744	ITPR3/RAP1A/PPP3R1/MAPK3	2.28697002803766
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/191	130/9376	2.26564639548933	EDN1/PRKCZ/GNAI2/RELA/MAPK3/NFKB1	2.09541408927149
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/191	68/9376	2.88758854327071	CCND1/RELA/MAPK3/NFKB1	2.25266360924562
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/191	99/9376	2.47924268866677	CCND1/MDM2/CDKN2A/BAX/MAPK3	2.1336146854929
Organismal Systems	Endocrine system	hsa04924	Renin secretion	4/191	69/9376	2.84573943394795	EDN1/GNAI2/ITPR3/PPP3R1	2.21897710288654
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	8/191	200/9376	1.96356020942408	TNFSF10/RAC1/GAPDH/CASP4/RELA/BAX/MAPK3/NFKB1	1.98623163295165
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/191	201/9376	1.95379125315829	BCL2L1/MDM2/KMT2A/GADD45B/BIRC3/RELA/BAX/NFKB1	1.97111094349013
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/191	70/9376	2.80508601346298	TGFB2/RAC1/RAP1A/MAPK3	2.18588917091238
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	4/191	71/9376	2.76557775975223	CCL5/RAC1/RELA/NFKB1	2.15337951191164
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	7/191	169/9376	2.03327240620837	OPTN/CFLAR/CTSD/BCL2L1/RRAS2/MAP1LC3A/MAPK3	1.95461781990335
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	7/191	170/9376	2.0213119802895	CCND1/DLG1/SYNPO/PRKCZ/RAC1/RAP1A/ACTN4	1.937805317234
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/191	75/9376	2.61808027923211	ENO1/TPI1/GAPDH/MAT2B	2.02875038781589
NA	NA	hsa03272	Virion - Hepatitis viruses	3/191	48/9376	3.06806282722513	CD9/CD81/LDLR	2.0713468101524
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/191	49/9376	3.0054493001389	GNAI2/RELA/NFKB1	2.02955806180577
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/191	149/9376	1.97673846586317	NDUFA13/GNAI2/MGLL/ITPR3/NDUFS5/MAPK3	1.73302132515106
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/191	115/9376	2.13430457546096	JUND/GNAI2/WNK1/ITPR3/MAPK3	1.76486871030127
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	6/191	150/9376	1.96356020942408	CCND1/TGFB2/GADD45B/CTNNB1/BAX/MAPK3	1.71545963395625
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/191	116/9376	2.1159053980863	GNAI2/SLC38A2/ITPR3/PPP3R1/MAPK3	1.74386805131914
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	8/191	226/9376	1.73766390214521	EDN1/GNAI2/RAC1/RAP1A/RELA/RRAS2/MAPK3/NFKB1	1.61869470345817
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	8/191	232/9376	1.69272431846904	ITGB4/RAC1/ITGAX/RRAS2/ITGA6/ACTN4/CFL2/MAPK3	1.54063251469218
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/191	122/9376	2.01184447686894	DLG1/PPP3R1/RELA/MAPK3/NFKB1	1.62215247943269
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	6/191	158/9376	1.86413943932666	CCND1/MDM2/TGFB2/GADD45B/CDKN2A/YWHAG	1.57963504376848
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	4/191	90/9376	2.18173356602676	SOD2/RELA/BAX/NFKB1	1.62438596327222
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/191	29/9376	3.38544863693808	FRMD6/RASSF1	1.85522115949644
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/191	59/9376	2.49605111367468	TYMP/NT5C3A/CMPK2	1.66225302265258
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	3/191	60/9376	2.4544502617801	RAC1/PPP3R1/MAPK3	1.62975567101516
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/191	60/9376	2.4544502617801	GNAI2/ITPR3/MAPK3	1.62975567101516
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/191	30/9376	3.27260034904014	RELA/NFKB1	1.79776760168825
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	6/191	168/9376	1.75317875841436	HSP90AA1/CFLAR/TNFSF10/EIF2AK2/BIRC3/BAX	1.42047236930402
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	11/191	368/9376	1.46733439562941	OPTN/NDUFA13/BCL2L1/RAC1/COX7A1/ITPR3/NDUFS5/PPP3R1/BAX/MAP1LC3A/SOD1	1.31886459026064
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/191	63/9376	2.33757167788581	GADD45B/CTNNB1/BAX	1.53604973974505
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/191	98/9376	2.00363286675927	RAC1/FCGR3A/CFL2/MAPK3	1.44020220106234
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	4/191	99/9376	1.98339415093342	ITGB4/EDN1/TGFB2/ITGA6	1.41841782834866
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/191	65/9376	2.26564639548933	KISS1/ITPR3/MAPK3	1.47650065212233
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/191	101/9376	1.94411901923177	EDN1/GNAI2/CTNNB1/MAPK3	1.3756033215766
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	5/191	139/9376	1.76579155523749	HSP90AA1/CTSD/GNAI2/ITPR3/MAPK3	1.31164178237286
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/191	217/9376	1.58351629792265	HSP90AA1/CCND1/GNAI2/RELA/KPNA2/MAPK3/NFKB1	1.2540693959552
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	3/191	67/9376	2.19801515980308	ENO1/TPI1/GAPDH	1.41909327315519
NA	NA	hsa04517	IgSF CAM signaling	9/191	299/9376	1.47759547531913	L1CAM/CD2/RAC1/RAP1A/CTNNB1/ITGAX/ACTN4/PTPRF/MAPK3	1.21028422208931
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	3/191	69/9376	2.13430457546096	FCER1G/RAC1/MAPK3	1.36367887815214
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/191	38/9376	2.58363185450537	NNMT/NMNAT2	1.41052839724836
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/191	38/9376	2.58363185450537	IL2RG/TAP1	1.41052839724836
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	4/191	109/9376	1.80143138479274	PRKCZ/RELA/PTPRF/NFKB1	1.21359213929159
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/191	148/9376	1.65841233904061	CCND1/GADD45B/CTNNB1/BAX/MAPK3	1.16422726955239
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	3/191	73/9376	2.01735637954529	MX2/SAMHD1/MDFIC	1.25830456982683
NA	NA	hsa04519	Cadherin signaling	11/191	404/9376	1.33658182572184	CDH13/RAC1/KRT7/EVL/RELA/CTNNB1/RRAS2/YWHAG/ACTN4/MAPK3/NFKB1	0.997239456725598
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/191	154/9376	1.59379887128578	CCND1/GNAI2/ITPR3/PPP3R1/MAPK3	1.07139572886191
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/191	195/9376	1.51043093032622	RAC1/FCGR3A/CASP4/RELA/MAPK3/NFKB1	1.03865672342208
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/191	42/9376	2.33757167788581	SLC39A14/MAP1LC3A	1.25276771519017
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/191	157/9376	1.56334411578351	C1QB/C1QA/RAC1/ELMO1/MAPK3	1.0264656548534
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	3/191	80/9376	1.84083769633508	BCL2L1/BAX/MAPK3	1.08911026457151
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/191	122/9376	1.60947558149515	CCND1/MDM2/CTNNB1/MAPK3	0.977089215069263
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	7/191	250/9376	1.37449214659686	HLA-C/IL2RG/PRKCZ/MDM2/CLTB/LDLR/CAV1	0.865436540887253
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	2/191	47/9376	2.08889383981286	PRKCZ/MAPK3	1.07914465699761
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/191	85/9376	1.73255312596243	TYMP/NT5C3A/CMPK2	0.978318126356428
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/191	166/9376	1.47858449504826	GNAI2/ITPR3/PPP3R1/PDE2A/MAPK3	0.897109787489164
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/191	86/9376	1.71240715938147	ITGB4/CTNNB1/ITGA6	0.957045058934804
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/191	89/9376	1.6546855697394	GNAI2/ITPR3/MAPK3	0.894855250377263
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/191	52/9376	1.88803866290777	LDLR/BMP6	0.925966244710954
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	8/191	308/9376	1.27503909702863	NDUFA13/CLTB/COX7A1/SOD2/NDUFS5/POLR2A/BAX/SOD1	0.70774494730125
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/191	17/9376	2.88758854327071	HSD3B7	1.12325875237815
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/191	17/9376	2.88758854327071	TXNRD2	1.12325875237815
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/191	178/9376	1.3789046414495	CCND1/RAC1/PPP3R1/CTNNB1/CSNK2B	0.735962973312727
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/191	138/9376	1.42286971697397	ITPR3/PPP3R1/YWHAG/MAPK3	0.721638825188728
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/191	56/9376	1.75317875841436	RELA/NFKB1	0.815167510717749
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	3/191	97/9376	1.5182166567712	GNAI2/ITPR3/MAPK3	0.73979158920576
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/191	98/9376	1.50272465006945	LDLR/ITPR3/PDE2A	0.721404381560555
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	4/191	142/9376	1.38278887987612	UBE2L6/MDM2/UBE2Z/BIRC3	0.66278289471424
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	8/191	323/9376	1.21582675506135	CCND1/MDM2/TGFB2/TNXB/CDKN2A/RASSF1/MAPK3/NFKB1	0.569210658504579
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/191	20/9376	2.4544502617801	DHCR24	0.93892630603139
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/191	59/9376	1.66403407578312	GNAI2/MGLL	0.737804102764649
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	3/191	102/9376	1.44379427163536	RAC1/ITPR3/RAP1A	0.64984678366354
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/191	62/9376	1.58351629792265	SOD2/SOD1	0.664727215351944
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/191	105/9376	1.40254300673149	ITGB4/TGFB2/ITGA6	0.598144875939685
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/191	65/9376	1.51043093032622	LDLR/ITPR3	0.595467742156128
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	3/191	110/9376	1.33879105188006	TGFB2/BMP6/MAPK3	0.515400537830944
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/191	110/9376	1.33879105188006	HSP90AA1/GNAI2/MAPK3	0.515400537830944
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	3/191	115/9376	1.28058274527658	GNAI2/ITPR3/MAPK3	0.436559737571212
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/191	115/9376	1.28058274527658	GNAI2/ITPR3/MAPK3	0.436559737571212
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/191	70/9376	1.40254300673149	RELA/NFKB1	0.487463972729361
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/191	116/9376	1.26954323885178	ENO1/TPI1/GAPDH	0.421225529949762
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/191	27/9376	1.8181113050223	ELOVL1	0.613867212413113
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/191	28/9376	1.75317875841436	ELOVL1	0.575546568071149
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	3/191	122/9376	1.20710668612136	GNAI2/ITPR3/MAPK3	0.332025950705835
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/191	76/9376	1.29181592725269	GNAI2/ITPR3	0.368329967989154
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/191	34/9376	1.44379427163536	POLR2A	0.373821228799141
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/191	83/9376	1.1828675960386	SOD2/SOD1	0.241301807384118
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/191	35/9376	1.40254300673149	TPI1	0.344042713081242
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	3/191	134/9376	1.09900757990154	EDN1/ITPR3/MAPK3	0.166456440528344
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/191	138/9376	1.06715228773048	NDUFA13/COX7A1/NDUFS5	0.114597229551772
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	3/191	138/9376	1.06715228773048	PRKCZ/PTPRF/MAPK3	0.114597229551772
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	1/191	38/9376	1.29181592725269	MAPK3	0.25991814384653
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/191	89/9376	1.1031237131596	GNAI2/SLC38A2	0.140954376306168
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/191	39/9376	1.25869244193852	MAT2B	0.23343990939883
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/191	91/9376	1.0788792359473	GNAI2/PDE2A	0.109032301347287
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	3/191	144/9376	1.02268760907504	ZFHX3/CTNNB1/MAPK3	0.0395625995337022
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/191	93/9376	1.05567753194843	ITPR3/MAPK3	0.0778108243445771
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	5/191	250/9376	0.981780104712042	CTSS/CTSD/CLTB/OSBPL3/CTSW	-0.0421054574752214
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	3/191	149/9376	0.988369232931586	FCER1G/RRAS2/MAPK3	-0.0206364017205094
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/191	44/9376	1.11565920990005	ARHGDIB	0.110887332408913
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	2/191	99/9376	0.991697075466709	RAC1/MAPK3	-0.0119758859398087
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/191	45/9376	1.09086678301338	TAP1	0.0881069274827446
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/191	154/9376	0.956279322771469	NMNAT2/MAT2B/CMPK2	-0.0788855437602434
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/191	46/9376	1.06715228773048	PSME2	0.0658357288949031
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	2/191	103/9376	0.953184567681594	SLC38A2/COL8A2	-0.0688906467898066
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	3/191	158/9376	0.932069719663331	CLIP1/CAB39/MAPK3	-0.124175620819288
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/191	50/9376	0.981780104712042	LAP3	-0.018627128681702
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	2/191	107/9376	0.91755149973088	ITPR3/PPP3R1	-0.12368611530248
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	1/191	52/9376	0.944019331453887	LDLR	-0.0583715682606906
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/191	53/9376	0.926207645954756	CLTB	-0.0776844685756649
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	3/191	168/9376	0.87658937920718	CCND1/BCL2L1/IL2RG	-0.232748700034918
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	1/191	54/9376	0.90905565251115	MAT2B	-0.0966453099944127
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/191	55/9376	0.892527367920038	UGCG	-0.115268520109085
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/191	56/9376	0.87658937920718	CCND1	-0.133567665609164
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/191	57/9376	0.861210618168458	ELOVL1	-0.15155551856827
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/191	59/9376	0.832017037891561	LAP3	-0.186644817123277
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	4/191	235/9376	0.835557535925142	NDUFA13/COX7A1/MGLL/NDUFS5	-0.368140666267739
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	2/191	122/9376	0.804737790747575	CCND1/CAB39	-0.313037313657593
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/191	61/9376	0.804737790747575	MT2A	-0.220624850338311
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/191	63/9376	0.779190559295271	KMT2A	-0.253574660360522
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/191	63/9376	0.779190559295271	POLR2A	-0.253574660360522
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/191	65/9376	0.755215465163109	MGLL	-0.285565167810079
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/191	133/9376	0.738180529858678	GNAI2/ITPR3	-0.438514567335811
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/191	69/9376	0.711434858486987	PPP3R1	-0.346917571316649
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/191	71/9376	0.691394439938058	MAPK3	-0.376389477398414
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	1/191	75/9376	0.654520069808028	ITPR3	-0.433163021239089
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/191	78/9376	0.629346220969258	TPI1	-0.474005852930534
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/191	78/9376	0.629346220969258	ENO1	-0.474005852930534
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/191	79/9376	0.621379813108887	CLTB	-0.487313718159345
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/191	82/9376	0.598646405312221	TYMP	-0.526375286334575
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/191	83/9376	0.591433798019302	CSNK2B	-0.539121009460825
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	2/191	154/9376	0.637519548514313	GNAI2/MAPK3	-0.654026180071318
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/191	86/9376	0.570802386460489	MAPK3	-0.576582435950296
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/191	86/9376	0.570802386460489	ITPR3	-0.576582435950296
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	1/191	86/9376	0.570802386460489	ITPR3	-0.576582435950296
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/191	87/9376	0.564241439489679	COX7A1	-0.588821709754518
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/191	90/9376	0.54543339150669	LDLR	-0.624837644826679
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/191	93/9376	0.527838765974216	ITPR3	-0.659857819795721
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/191	98/9376	0.500908216689817	ITPR3	-0.716191257443007
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/191	99/9376	0.495848537733355	ITPR3	-0.727172743084045
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/191	174/9376	0.564241439489679	HSP90AA1/BAX	-0.836646847171342
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/191	108/9376	0.454527826255575	KPNA2	-0.822155956222728
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/191	191/9376	0.514020997231436	GNAI2/MAPK3	-0.978492160062236
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/191	117/9376	0.419564147312838	RUVBL2	-0.911019893734529
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/191	128/9376	0.383507853403141	PDE2A	-1.01267797463787
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	4/191	370/9376	0.530691948492996	KISS1/GZMA/F2RL3/EDN1	-1.32817602749609
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/191	144/9376	0.340895869691681	ITPR3	-1.1493442377355
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/191	243/9376	0.4040247344494	ZMAT2/SNRNP70	-1.3573360545591
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/191	254/9376	0.386527600280331	ITPR3/PPP3R1	-1.42932040695263
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/191	183/9376	0.268245930249192	CSNK2B	-1.44153371023672
Cellular Processes	Cell motility	hsa04814	Motor proteins	1/191	194/9376	0.253036109461866	KIF1C	-1.51598383376665
NA	NA	hsa04082	Neuroactive ligand signaling	1/191	199/9376	0.246678418269357	GNAI2	-1.54888553337406
NA	NA	hsa04081	Hormone signaling	1/191	219/9376	0.224150708838366	GNAI2	-1.67527288578021
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/191	449/9376	0.10932963304143	PDE2A	-2.78901049159937