category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	65/1190	233/9376	2.19800194756014	THBS1/COL4A1/ACTG2/NID1/COL4A2/FBN1/COL6A3/ITGB8/MYH11/TLN2/SGCD/ITGA6/LMOD1/CSRP1/SDC4/VCL/SYNPO2/SYNE2/DMD/SDC2/FBLN1/PDLIM1/COL4A4/THBS3/FHL1/DAAM1/SSPN/DES/COL5A3/COL4A3/SDC3/DIAPH2/FBN2/SYNE1/TPM1/ZYX/ITGA1/PDLIM5/PDLIM3/TMOD1/TMOD2/DTNA/DIAPH1/AMPD3/CAPN3/ITGA5/FBLN2/FHL3/COL27A1/TNNT2/SPTBN1/THBS4/COL24A1/SDC1/ANKRD1/HSPG2/COMP/ITGA7/SUN1/SNTB2/SUN2/FMNL2/DAG1/MYH9/COL11A1	7.06015723860864
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	58/1190	203/9376	2.25114045618247	THBS1/AKT3/COL4A1/EMP1/COL4A2/PDGFD/COL6A3/FLT1/ITGB8/TNC/TLN2/VWF/LAMB1/PIK3R1/ITGA6/PAK3/IGF1R/BCL2/MAPK10/VCL/PTEN/COL4A4/THBS3/PDGFRA/EGFR/PPP1R12B/LAMA3/PDGFRB/COL4A3/TNXB/MYLK/ZYX/ITGA1/VEGFA/FLT4/RELN/DIAPH1/PARVA/ITGA5/PIP5K1C/ACTN4/PPP1R12C/FYN/CAV1/THBS4/PIK3CB/JUN/IGF1/COMP/ROCK2/RAP1B/RAPGEF1/ITGA7/CAPN2/AKT2/PIK3CA/LAMC3/CCND3	6.87102673491594
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	75/1190	300/9376	1.96974789915966	INSR/AKT3/DUSP1/PDGFD/FLT1/CACNB2/NTRK1/NR4A1/RASGRP2/MAP3K5/NFATC1/FOS/IGF1R/MAPK10/HSPA6/JUND/GADD45A/GADD45B/HSPA1B/PDGFRA/EGFR/NGF/MRAS/MAP2K3/MYC/PDGFRB/RPS6KA2/MAPKAPK2/MAP3K4/FGFR1/DUSP2/VEGFA/FLT4/TGFBR2/ANGPT2/CACNA1C/HSPA1A/HSPB1/GADD45G/CACNA1H/PLA2G4A/MAP3K14/DUSP16/FLT3LG/RASGRF2/TEK/IL1R1/IGF2/TGFBR1/PPP3CB/IL1RAP/RRAS2/DUSP8/EREG/PPM1B/FGF1/RASA2/NGFR/FAS/JUN/RELA/IGF1/PTPN7/RAP1B/RAPGEF2/SRF/TRAF6/AKT2/MAPK11/STK3/CACNA1D/CACNB1/NTRK2/ELK4/RASGRP1	6.50871836619578
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	37/1190	109/9376	2.67452008326266	NFATC1/FOS/MAPK10/JAK2/RORA/HLA-DRB1/NFATC2/HLA-DQB1/HLA-DPB1/HLA-DRB5/IL4R/SMAD3/HLA-DRA/STAT5A/IL6R/TGFBR2/HLA-DQA1/STAT5B/NFKBIA/HLA-DPA1/IL1R1/GATA3/TGFBR1/PPP3CB/IL1RAP/STAT3/IL6ST/JUN/RELA/RARA/PRKCQ/HSP90AB1/NFKBIB/CD3E/MAPK11/HSP90AA1/EBI3	6.70435923579045
NA	NA	hsa04518	Integrin signaling	45/1190	154/9376	2.30230273927753	THBS1/AKT3/COL4A1/COL4A2/FBN1/PDGFD/COL6A3/FLT1/ITGB8/TNC/TLN2/VWF/LAMB1/PIK3R1/ITGA6/IGF1R/VCL/FERMT2/COL4A4/THBS3/PDGFRA/EGFR/LAMA3/PDGFRB/COL4A3/TNXB/ITGA1/NPNT/VEGFA/FLT4/RELN/PARVA/ITGA5/ACTN4/THBS4/PIK3CB/ARHGEF6/IGF1/COMP/ITGA7/AKT2/PIK3CA/LIMS2/LAMC3/CCND3	6.21273750065588
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	34/1190	101/9376	2.65233380480905	FOXO1/AKT3/SERPINE1/COL4A1/COL4A2/PIK3R1/NFATC1/NOX4/BCL2/MAPK10/PLCG2/JAK2/COL4A4/PIM1/COL4A3/PRKCE/VEGFA/PLCE1/SMAD3/DIAPH1/STAT5A/TGFBR2/STAT5B/TGFBR1/STAT3/PIK3CB/EGR1/JUN/RELA/AGT/EDN1/AKT2/PIK3CA/MAPK11	6.36538629293569
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	58/1190	224/9376	2.04009603841537	AKT3/ZFP36/IL15/TLN2/PIK3R1/NFATC1/CREB5/FOS/MAPK10/HLA-G/PTEN/HLA-DRB1/ADCY1/FOSL1/NFATC2/MYC/HLA-DQB1/MSX1/HLA-DPB1/HLA-DRB5/SMAD3/HLA-DRA/STAT5A/ADCY2/CREB3L2/TGFBR2/HLA-DQA1/ETS1/MAP3K14/MMP7/STAT5B/NFKBIA/HLA-DPA1/ANAPC7/IL1R1/TGFBR1/PPP3CB/ADCY3/KAT2A/PIK3CB/CRTC3/EGR1/JUN/RELA/KAT2B/ADCY9/BCL2L1/SRF/CD3E/IL1R2/AKT2/PIK3CA/CREB3L1/CCND3/ELK4/ADCY4/IL15RA/NFYB	6.0070700222985
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	81/1190	362/9376	1.76297878267329	THBS1/INSR/AKT3/COL4A1/LPAR1/COL4A2/PDGFD/COL6A3/FLT1/ITGB8/TNC/NTRK1/VWF/F2R/NR4A1/PRLR/LAMB1/PIK3R1/ITGA6/CREB5/IGF1R/BCL2/MCL1/JAK2/FOXO3/PTEN/COL4A4/THBS3/GNG4/PDGFRA/EGFR/NGF/CSF3/MYC/TLR4/LAMA3/PDGFRB/COL4A3/GHR/TNXB/ITGA1/FGFR1/CSH2/IL4R/VEGFA/FLT4/RELN/IL6R/CREB3L2/ANGPT2/ITGA5/PPP2R3A/GNB5/FLT3LG/TEK/SGK1/IGF2/PHLPP2/PPP2R1B/EREG/THBS4/PIK3CB/FGF1/NGFR/RELA/IGF1/COMP/ITGA7/IL7/BCL2L1/IRS1/IL7R/HSP90AB1/PPP2R5D/AKT2/PIK3CA/CREB3L1/LAMC3/CCND3/HSP90AA1/NTRK2	5.64457461323125
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	23/1190	62/9376	2.92285172133369	FOXO1/INSR/IRS2/AKT3/PIK3R1/IGF1R/HSPA6/FOXO3/HSPA1B/CRYAB/ADCY1/PRKAB2/ADCY2/HSPA1A/ADCY3/PIK3CB/IGF1/ADCY9/IRS1/AKT2/PIK3CA/PRKAG2/ADCY4	5.79157616422722
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	29/1190	90/9376	2.53878618113912	FOXO1/INSR/IRS2/AKT3/PIK3R1/CREB5/IGF1R/FOXO3/SESN1/PPARG/ADCY1/PRKAB2/ADCY2/CREB3L2/CAMKK2/ADCY3/PPARGC1A/PIK3CB/RB1CC1/RELA/IGF1/ADCY9/IRS1/AKT2/PIK3CA/SESN3/PRKAG2/CREB3L1/ADCY4	5.59253153066396
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	57/1190	238/9376	1.88698538238825	INSR/AKT3/PDGFD/FLT1/NTRK1/RASAL2/RASGRP2/PIK3R1/PAK3/IGF1R/MAPK10/PLCG2/GNG4/GAB2/PDGFRA/EGFR/NGF/PLA2G2A/MRAS/PLA2G5/PDGFRB/ABL2/FGFR1/VEGFA/PLCE1/FLT4/PLA1A/ANGPT2/ETS1/GNB5/AFDN/PLA2G4A/KSR1/PTPN11/FLT3LG/TIAM1/RASGRF2/TEK/IGF2/RALGAPA1/RRAS2/PLA2G6/RAPGEF5/PIK3CB/FGF1/RASA2/REL/NGFR/SHOC2/RELA/IGF1/RAP1B/BCL2L1/AKT2/PIK3CA/NTRK2/RASGRP1	5.28448431357461
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	29/1190	93/9376	2.45688985271528	NFATC1/FOS/MAPK10/JAK2/HLA-DRB1/NFATC2/HLA-DQB1/HLA-DPB1/HLA-DRB5/IL4R/HLA-DRA/STAT5A/HLA-DQA1/NOTCH3/DLL1/STAT5B/NFKBIA/HLA-DPA1/GATA3/MAML3/PPP3CB/STAT4/JUN/RELA/PRKCQ/NFKBIB/CD3E/RUNX3/MAPK11	5.38328368034374
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	28/1190	89/9376	2.4787838730998	THBS1/COL4A1/COL4A2/COL6A3/ITGB8/TNC/VWF/LAMB1/ITGA6/SDC4/COL4A4/THBS3/LAMA3/COL4A3/TNXB/ITGA1/NPNT/RELN/ITGA5/GP1BB/CD44/THBS4/SDC1/HSPG2/COMP/ITGA7/DAG1/LAMC3	5.34423116139807
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	51/1190	212/9376	1.89541778975741	THBS1/INSR/AKT3/CNR1/LPAR1/PDGFD/FLT1/TLN2/F2R/RASGRP2/PIK3R1/IGF1R/PDGFRA/EGFR/NGF/MRAS/ADCY1/MAP2K3/PDGFRB/GNAI1/GNAO1/APBB1IP/FGFR1/VEGFA/PLCE1/FLT4/ADCY2/ANGPT2/AFDN/PARD3/TIAM1/TEK/RAPGEF4/ADCY3/RAPGEF5/PIK3CB/FGF1/NGFR/IGF1/PRKD1/RAP1B/ADCY9/RAPGEF1/RAPGEF2/AKT2/PIK3CA/SKAP1/P2RY1/DOCK4/MAPK11/ADCY4	5.02775790430503
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	34/1190	122/9376	2.19578454332553	IRS2/AKT3/IGFBP3/PIK3R1/CREB5/FOS/MAPK10/PLCG2/JAK2/ADCY1/MAP2K3/GHR/GNAI1/CSH2/STAT5A/ADCY2/CREB3L2/CACNA1C/JUNB/STAT5B/SOCS2/SOCS3/ADCY3/STAT3/PIK3CB/IGF1/ADCY9/IRS1/AKT2/PIK3CA/CREB3L1/MAPK11/CACNA1D/ADCY4	5.06863889561792
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	21/1190	59/9376	2.80438683948155	INSR/IRS2/AKT3/PIK3R1/PTGER3/NPR1/FABP4/ADCY1/GNAI1/MGLL/ABHD5/ADCY2/NPY1R/ADCY3/PTGS2/PIK3CB/ADCY9/IRS1/AKT2/PIK3CA/ADCY4	5.30079315436667
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	32/1190	112/9376	2.25114045618247	AKT3/LAMB1/ITGA6/BCL2/MAPK10/HSPA6/JAK2/HSPA1B/HLA-DRB1/MAP2K3/TLR4/LAMA3/HLA-DQB1/HLA-DPB1/HLA-DRB5/GNAI1/GNAO1/HLA-DRA/HLA-DQA1/HSPA1A/NFKBIA/HLA-DPA1/STAT3/RELA/BCL2L1/NFKBIB/TRAF6/AKT2/CIITA/MAPK11/LAMC3/IL10	5.07854206842633
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	36/1190	134/9376	2.11674401103725	ACTG2/MYH11/CALD1/NPR1/ACTA2/AVPR1A/CALCRL/RAMP1/EDNRA/KCNMB1/PLA2G2A/ADCY1/PLA2G5/PPP1R12B/ADM/MYLK/PRKCE/RAMP3/ADCY2/CACNA1C/PLA2G4A/KCNMA1/PPP1R12C/PPP1R14A/ADCY3/PLA2G6/PRKCH/AGT/ROCK2/EDN1/ADCY9/PRKCQ/GUCY1B1/CACNA1D/MYH9/ADCY4	4.96416602499542
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	31/1190	109/9376	2.24081412381466	FOXO1/INSR/IRS2/AKT3/PIK3R1/CREB5/MAPK10/PTEN/PRKAB2/RPS6KA2/PRKCE/CREB3L2/PYGM/SLC27A5/PTPN11/NFKBIA/SOCS3/PTPN1/PPARGC1A/STAT3/PIK3CB/PPP1R3B/RELA/AGT/IRS1/PRKCQ/ACACB/AKT2/PIK3CA/PRKAG2/CREB3L1	4.96790914247351
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	27/1190	90/9376	2.3636974789916	AKT3/PIK3R1/NFATC1/FOS/JAK2/PTEN/EGFR/NFATC2/MAP2K3/TLR4/BATF3/PTPN11/NFKBIA/PPP3CB/STAT3/PIK3CB/JUN/RELA/PRKCQ/NFKBIB/CD3E/TRAF6/TICAM1/AKT2/PIK3CA/MAPK11/RASGRP1	4.95619290257841
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	30/1190	106/9376	2.22990328206754	FOXO1/AKT3/ZEB1/AR/PDGFD/TCF7L2/PIK3R1/CREB5/IGF1R/PLAT/BCL2/PTEN/PDGFRA/EGFR/PDGFRB/TCF7L1/FGFR1/INSRR/CREB3L2/ERG/NFKBIA/PIK3CB/RELA/IGF1/HSP90AB1/IL1R2/AKT2/PIK3CA/CREB3L1/HSP90AA1	4.85520167994665
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	35/1190	133/9376	2.0734188412207	FOXO1/INSR/IRS2/AKT3/PIK3R1/IGF1R/DEPP1/MAPK10/BCL6/HOMER1/FOXO3/GADD45A/PLK3/PTEN/GADD45B/EGFR/GABARAPL1/PRKAB2/SMAD3/TGFBR2/GADD45G/TNFSF10/SGK1/TGFBR1/STAT3/PIK3CB/IGF1/IRS1/FBXO32/IL7R/AKT2/PIK3CA/PRKAG2/MAPK11/IL10	4.75348148542018
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	27/1190	93/9376	2.28744917321767	INSR/TCF7L2/SORBS1/IGF1R/VCL/PTPRM/EGFR/TCF7L1/FGFR1/SMAD3/TGFBR2/ARHGAP29/AFDN/ACTN4/PARD3/RADIL/WASF1/FYN/PTPN1/TGFBR1/SSX2IP/IQGAP1/ROCK2/RAP1B/CTNNA3/SMURF1/WASF3	4.75719156842066
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	34/1190	130/9376	2.06065934065934	AKT3/COL4A1/COL4A2/PIK3R1/CREB5/FOS/MAPK10/ACTA2/COL4A4/GNG4/EGFR/ADCY1/COL4A3/GNAI1/GNAO1/RXFP1/VEGFA/ADCY2/CREB3L2/TGFBR2/GNB5/NFKBIA/TGFBR1/ADCY3/PIK3CB/JUN/RELA/EDN1/ADCY9/AKT2/PIK3CA/CREB3L1/MAPK11/ADCY4	4.64294887203827
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	47/1190	204/9376	1.81525786785302	TIMP3/THBS1/AKT3/HOXD10/PIK3R1/IGF1R/SDC4/ESR1/PLCG2/SDC2/EGFR/MRAS/MYC/TLR4/PPP1R12B/HSPB2/FGFR1/VEGFA/PLCE1/ITGA5/FZD8/CAMK2D/PTPN11/PPP1R12C/TIAM1/WNT9A/TWIST2/CAV1/LUM/IGF2/CD44/RRAS2/STAT3/PIK3CB/SDC1/IQGAP1/HSPG2/FAS/IGF1/ROCK2/DDX5/AKT2/PIK3CA/MAPK11/WNT2B/CBL/WNT5A	4.48850081310197
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	42/1190	178/9376	1.85908790482485	DKK1/CCN4/TCF7L2/NFATC1/TLE2/RSPO1/MAPK10/ROR1/SFRP2/PRICKLE2/DAAM1/FOSL1/NFATC2/MYC/MCC/TCF7L1/TBL1X/APCDD1/NOTUM/SMAD3/CTBP2/FZD8/MMP7/CAMK2D/TLE6/LGR4/WNT9A/ROR2/CXXC4/PPP3CB/SFRP4/JUN/NKD1/ROCK2/SERPINF1/PSEN1/LRP5/AXIN1/ANKRD6/CCND3/WNT2B/WNT5A	4.41188467766279
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	38/1190	157/9376	1.90701707434566	FOXO1/AKT3/SERPINE1/IGFBP3/HIPK3/PIK3R1/NFATC1/ZFP36L1/FOXO3/GADD45A/HLA-G/PTEN/NBN/GADD45B/ZFP36L2/MRAS/NFATC2/MAP2K3/MYC/MAPKAPK2/SMAD3/TGFBR2/ETS1/GADD45G/TGFBR1/PPP3CB/RRAS2/PIK3CB/RAD9A/RELA/MCU/CAPN2/AKT2/PIK3CA/HUS1/MAPK11/CCND3/CACNA1D	4.36964977665703
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	31/1190	119/9376	2.05251041593108	AKT3/IL15/MAP3K5/PIK3R1/CREB5/FOS/MAPK10/MAP2K3/DAB2IP/TNFAIP3/IRF1/CREB3L2/CFLAR/TRAF1/MAP3K14/JUNB/CXCL2/NFKBIA/SOCS3/ADAM17/TRAF5/PTGS2/PIK3CB/FAS/JUN/RELA/EDN1/AKT2/PIK3CA/CREB3L1/MAPK11	4.40542690693124
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	28/1190	103/9376	2.14186179326099	AKT3/SERPINE1/PIK3R1/FOS/MAPK10/ACE/ADCY1/TLR4/GNAI1/GNAO1/TGFBR2/CFLAR/KNG1/GNAL/NFKBIA/PPP2R1B/TGFBR1/PIK3CB/FAS/JUN/RELA/CD3E/TRAF6/TICAM1/AKT2/PIK3CA/MAPK11/IL10	4.44268245660501
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	26/1190	93/9376	2.20272883346887	AKT3/COL4A1/COL4A2/LAMB1/PIK3R1/ITGA6/BCL2/GADD45A/PTEN/COL4A4/GADD45B/MYC/LAMA3/COL4A3/TRAF1/GADD45G/NFKBIA/TRAF5/PTGS2/PIK3CB/RELA/BCL2L1/TRAF6/AKT2/PIK3CA/LAMC3	4.44414551245912
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	31/1190	120/9376	2.03540616246499	AKT3/NTRK1/MAP3K5/PIK3R1/BCL2/MAPK10/PLCG2/FOXO3/NGF/RPS6KA2/MAPKAPK2/RIPK2/CAMK2D/PTPN11/NFKBIA/PIK3CB/NGFR/JUN/RELA/RAP1B/RAPGEF1/PSEN1/IRS1/NFKBIB/SORT1/NTRK3/TRAF6/AKT2/PIK3CA/MAPK11/NTRK2	4.35224108391882
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	27/1190	99/9376	2.14881588999236	NTRK1/PIK3R1/MAPK10/PLCG2/NGF/ADCY1/MAP2K3/HTR2A/PRKCE/HTR2B/ADCY2/KNG1/PLA2G4A/CAMK2D/IL1R1/ADCY3/IL1RAP/PLA2G6/PRKCH/PIK3CB/IGF1/ADCY9/PRKCQ/PIK3CA/ASIC2/MAPK11/ADCY4	4.38114373590938
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	28/1190	105/9376	2.10106442577031	AKT3/CBLB/PIK3R1/NFATC1/MAPK10/PLCG2/PLK3/EGR3/MRAS/NFATC2/MAPKAPK2/IRF1/KSR1/MAP3K14/PTPN11/NFKBIA/PPP3CB/IL17D/RRAS2/PTGS2/PIK3CB/JUN/RELA/CARD9/AKT2/PIK3CA/MAPK11/IL10	4.32580899143862
NA	NA	hsa04517	IgSF CAM signaling	61/1190	299/9376	1.60741969028414	FOXO1/AKT3/NLGN1/MYH11/NLGN4X/SORBS1/PIK3R1/PAK3/MAPK10/VCL/PPFIA2/PLCG2/KCNQ3/MBP/TJP2/LRFN5/MYLK/FGFR1/TRPC6/UNC5C/LRRC4C/ITGA5/CNTN1/JAM2/AFDN/ACTN4/NFASC/PTPN11/PARD3/TRIO/FYN/SCN8A/SPTBN1/IL1RAP/SSX2IP/PIK3CB/CD2/NTN1/IQGAP1/PLXNA4/TUBA1A/CD96/RAP1B/CLMP/F11R/RAPGEF2/PRKCQ/PMP22/NTRK3/SRGAP1/MAP2/TRAF6/ESAM/AKT2/CD2AP/PIK3CA/CNTNAP2/JAM3/MAPK11/ROBO4/MYH9	4.06983255287568
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	39/1190	168/9376	1.82905162064826	AKT3/IL15/AOX1/PRLR/PIK3R1/BCL2/MCL1/JAK2/PIM1/FHL1/PDGFRA/EGFR/CSF3/MYC/CLCF1/PDGFRB/GHR/CSH2/IL4R/STAT5A/IL6R/STAT5B/PTPN11/SOCS2/IL19/SOCS3/LIFR/STAT3/PIK3CB/IL6ST/STAT4/IL7/BCL2L1/IL7R/AKT2/PIK3CA/IL10/CCND3/IL15RA	4.13406029886521
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	37/1190	157/9376	1.85683241449446	SERPINE1/TEAD1/TCF7L2/SMAD7/CCN2/FRMD6/MYC/GDF7/BMP6/TCF7L1/SMAD3/TGFBR2/WTIP/DLG2/FZD8/LLGL2/WWTR1/PARD3/WNT9A/PPP2R1B/TGFBR1/SMAD1/FGF1/BBC3/AMOT/NKD1/LATS2/BMPR1B/TP53BP2/AXIN1/CTNNA3/TEAD3/TEAD4/CCND3/STK3/WNT2B/WNT5A	4.12787992037443
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	53/1190	254/9376	1.64404155362933	PDE1A/PDGFD/FLT1/NTRK1/F2R/NFATC1/PTGER3/STIM1/PLCG2/ITPKC/AVPR1A/OXTR/PDGFRA/EGFR/NGF/EDNRA/ITPKB/CAMK1/ADCY1/NFATC2/PDGFRB/HTR2A/MYLK/CXCR4/FGFR1/VEGFA/PLCE1/FLT4/HTR2B/ADCY2/CAMK1G/CACNA1C/CACNA1H/PLN/CAMK2D/GNAL/PPP3CB/ADCY3/ATP2B4/FGF1/PTK2B/SLC8A1/ADCY9/TPCN1/RYR3/CHRM5/PDE1C/MCU/NTRK3/P2RX1/CACNA1D/NTRK2/ADCY4	3.96742716018832
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	13/1190	34/9376	3.01255561047949	RORB/NR1D1/RORA/PER2/PRKAB2/NR1D2/CRY1/CRY2/PER1/NFIL3/BHLHE40/PER3/PRKAG2	4.48219415910924
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	36/1190	154/9376	1.84184219142202	CACNB2/NFATC1/FOS/NPR1/OXTR/EGFR/RGS2/CAMK1/ADCY1/NFATC2/PPP1R12B/PRKAB2/MYLK/GNAI1/GNAO1/ADCY2/CAMK1G/CACNA1C/PLA2G4A/CAMK2D/PPP1R12C/CAMKK2/OXT/PPP3CB/RCAN1/ADCY3/PTGS2/JUN/ROCK2/ADCY9/RYR3/GUCY1B1/PRKAG2/CACNA1D/CACNB1/ADCY4	4.01607429251314
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	33/1190	137/9376	1.89785928970128	AKT3/NTRK1/MAP3K5/PIK3R1/FOS/BCL2/CTSK/MAPK10/MCL1/CTSH/GADD45A/GADD45B/PTPN13/NGF/DAB2IP/ERN1/CFLAR/TRAF1/EIF2AK3/GADD45G/MAP3K14/NFKBIA/TNFSF10/PIK3CB/BBC3/FAS/JUN/RELA/TUBA1A/BCL2L1/CAPN2/AKT2/PIK3CA	4.03626181409567
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	38/1190	166/9376	1.80362458236307	INSR/IRS2/AKT3/ADRA2C/NFATC1/CREB5/NPR1/EDNRA/RGS2/KCNMB1/ADCY1/NFATC2/MYLK/GNAI1/PRKCE/TRPC6/ADCY2/CREB3L2/CACNA1C/KNG1/PLN/KCNMA1/PDE5A/MEF2D/PPP3CB/ADCY3/ATP2B4/PDE2A/ROCK2/SLC8A1/ADCY9/IRS1/SRF/GUCY1B1/AKT2/CREB3L1/CACNA1D/ADCY4	3.98291181372484
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	35/1190	149/9376	1.8507698381366	INSR/AKT3/LPAR1/PDGFD/F2R/PIK3R1/PLCG2/AVPR1A/GAB2/PDGFRA/EGFR/MRAS/ADCY1/PDGFRB/PLPP1/ADCY2/GRM7/PIP5K1C/DGKA/PLA2G4A/PTPN11/FYN/RAPGEF4/ADCY3/RRAS2/PIK3CB/PTK2B/AGT/ADCY9/DNM3/AKT2/PIK3CA/ARF1/CYTH3/ADCY4	3.99115144375869
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	28/1190	110/9376	2.0055614973262	INSR/AKT3/SERPINE1/FLT1/TF/PIK3R1/IGF1R/BCL2/PLCG2/EGFR/ALDOB/TLR4/EGLN3/VEGFA/IL6R/ANGPT2/PFKFB3/CAMK2D/TEK/TFRC/STAT3/PIK3CB/RELA/IGF1/EPAS1/EDN1/AKT2/PIK3CA	4.04466055236154
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	27/1190	105/9376	2.02602641056423	ITGB8/CACNB2/SGCD/ITGA6/DMD/SSPN/ADCY1/DES/TPM1/ITGA1/DTNA/ADCY2/CACNA1C/ITGA5/PLN/TNNT2/ADCY3/AGT/IGF1/SLC8A1/ADCY9/ITGA7/SNTB2/DAG1/CACNA1D/CACNB1/ADCY4	4.03100324412635
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	26/1190	100/9376	2.04853781512605	ITGA6/CSF3/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/ITGA1/IL4R/CD55/HLA-DRA/IL6R/HLA-DQA1/ITGA5/GP1BB/FLT3LG/HLA-DPA1/IL1R1/CD44/TFRC/CD2/CD34/IL7/IL7R/CD3E/MME/IL1R2	4.01908301299359
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	22/1190	80/9376	2.16672268907563	AKT3/PDGFD/PIK3R1/IGF1R/BCL2/PLCG2/JAK2/FOXO3/PTEN/PDGFRA/EGFR/AXL/PDGFRB/VEGFA/IL6R/STAT3/PIK3CB/NRG2/IGF1/BCL2L1/AKT2/PIK3CA	3.99565358112836
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	43/1190	201/9376	1.68555541619633	FOXO1/ZBTB16/ZEB1/MITF/FLT1/IGFBP3/NTRK1/WT1/IGF1R/PLAT/PBX1/AFF1/BCL6/GADD45A/GADD45B/PPARG/PER2/MYC/TGFBR2/TRAF1/ERG/HOXA10/GADD45G/MLF1/DOT1L/HPGD/ELANE/PBX3/SMAD1/JMJD1C/REL/NGFR/RELA/IGF1/RARA/DDX5/BCL2L1/KDM6A/NFKBIZ/IL1R2/TFE3/SIN3A/ELK4	3.74593991761605
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	34/1190	148/9376	1.81003861003861	AKT3/PGR/TCF7L2/PIK3R1/FOS/IGF1R/ESR1/GADD45A/PTEN/GADD45B/NCOA1/EGFR/MYC/HES1/TCF7L1/FGFR1/FLT4/GADD45G/FZD8/NOTCH3/DLL1/WNT9A/PIK3CB/FGF1/JUN/IGF1/LRP5/AXIN1/AKT2/PIK3CA/WNT2B/ESR2/NOTCH4/WNT5A	3.78709354961443
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	20/1190	71/9376	2.21943425257427	AKT3/PRLR/PIK3R1/FOS/MAPK10/ESR1/JAK2/FOXO3/IRF1/STAT5A/STAT5B/SOCS2/SOCS3/STAT3/PIK3CB/RELA/AKT2/PIK3CA/MAPK11/ESR2	3.93235415324143
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	23/1190	87/9376	2.08295180141022	AKT3/TCF7L2/PIK3R1/FOS/BCL2/MAPK10/GADD45A/GADD45B/EGFR/MYC/TCF7L1/SMAD3/TGFBR2/GADD45G/TGFBR1/EREG/PIK3CB/MLH1/BBC3/JUN/AXIN1/AKT2/PIK3CA	3.86907832556338
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	21/1190	77/9376	2.14881588999236	AKT3/PIK3R1/GADD45A/GADD45B/GAB2/MYC/SMAD3/STAT5A/TGFBR2/CTBP2/GADD45G/STAT5B/PTPN11/NFKBIA/TGFBR1/PIK3CB/RELA/BCL2L1/AKT2/PIK3CA/CBL	3.85923230378883
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	27/1190	110/9376	1.93393430099312	THBS1/FBN1/TF/ID4/SMAD7/LTBP1/CHRD/LEFTY2/MYC/GDF7/RGMA/BMP6/SMAD3/SKI/TGFBR2/FMOD/PPP2R1B/TGFBR1/SMAD1/LRRC32/TFRC/THSD4/BMPR1B/SMURF1/ACVR1B/NOG/SIN3A	3.75655515427799
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	25/1190	99/9376	1.98964434258552	ITGB8/CACNB2/SGCD/ITGA6/DMD/ACE/SSPN/DES/PRKAB2/TPM1/ITGA1/DTNA/CACNA1C/ITGA5/TNNT2/AGT/IGF1/SLC8A1/EDN1/ITGA7/SNTB2/PRKAG2/DAG1/CACNA1D/CACNB1	3.77412442678307
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	32/1190	139/9376	1.81386856901034	AKT3/GREB1/PGR/FKBP5/PIK3R1/CREB5/FOS/BCL2/ESR1/HSPA6/NCOA1/HSPA1B/EGFR/ADCY1/GNAI1/GNAO1/ADCY2/CREB3L2/HSPA1A/ADCY3/PIK3CB/KRT18/JUN/RARA/ADCY9/HSP90AB1/AKT2/PIK3CA/CREB3L1/HSP90AA1/ESR2/ADCY4	3.68569551144954
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	21/1190	78/9376	2.12126696832579	INPP4B/PLCG2/ITPKC/PTEN/ITPKB/IMPA2/PLCH1/PLCE1/PIP5K1C/INPP5A/ITPK1/INPP4A/PIK3CB/MTMR3/IP6K3/INPP1/INPP5B/PIK3CA/MTMR1/INPP5F/PIP4K2A	3.79127081334511
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	63/1190	333/9376	1.4906200317965	FOXO1/THBS1/AKT3/COL4A1/COL4A2/COL6A3/ITGB8/TCF7L2/TNC/VWF/LAMB1/PIK3R1/ITGA6/CREB5/HLA-G/PTEN/HES4/COL4A4/THBS3/EGFR/LAMA3/PDGFRB/COL4A3/TNXB/HES1/ITGA1/TCF7L1/VEGFA/IRF1/RELN/CREB3L2/ATP6V0A1/ITGA5/DLG2/PPP2R3A/FZD8/NOTCH3/LLGL2/PARD3/WNT9A/MAML3/RFNG/PPP2R1B/MX2/PTGS2/THBS4/PIK3CB/FAS/RELA/COMP/ITGA7/PSEN1/AXIN1/PPP2R5D/TICAM1/AKT2/PIK3CA/CREB3L1/LAMC3/CCND3/WNT2B/NOTCH4/WNT5A	3.47563671577755
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	47/1190	232/9376	1.59617502173283	RGCC/AKT3/LPAR1/PDGFD/ITGB8/MYH11/F2R/PIK3R1/ITGA6/PAK3/VCL/GSN/C7/PDGFRA/EGFR/MRAS/PPP1R12B/PDGFRB/DIAPH2/MYLK/ITGA1/CXCR4/CXCL12/FGFR1/INSRR/DIAPH1/ITGA5/PIP5K1C/KNG1/ACTN4/PPP1R12C/TIAM1/WASF1/ARHGEF7/CYFIP2/RRAS2/PIK3CB/FGF1/ARHGEF6/IQGAP1/ROCK2/ITGA7/CHRM5/AKT2/PIK3CA/PIP4K2A/MYH9	3.50568514778688
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	32/1190	142/9376	1.77554740205942	AKT3/MITF/FOSB/PIK3R1/NFATC1/FOS/CTSK/MAPK10/PLCG2/JUND/PPARG/GAB2/FOSL1/NFATC2/FOSL2/TGFBR2/MAP3K14/JUNB/NFKBIA/SOCS3/FYN/IL1R1/TGFBR1/PPP3CB/PIK3CB/JUN/RELA/ACP5/TRAF6/AKT2/PIK3CA/MAPK11	3.55042900793665
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	17/1190	59/9376	2.27021791767554	AKT3/TCF7L2/PIK3R1/FOXO3/GADD45A/PTEN/GADD45B/EGFR/MYC/TCF7L1/GADD45G/PIK3CB/MLH1/AXIN1/CTNNA3/AKT2/PIK3CA	3.73155151392205
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	19/1190	70/9376	2.13858343337335	IRS2/AKT3/MAPK10/JAK2/PRKAB2/ACSL1/PTPN11/CAMKK2/NFKBIA/SOCS3/PPARGC1A/STAT3/RELA/IRS1/PRKCQ/NFKBIB/ACACB/AKT2/PRKAG2	3.64548743010395
Organismal Systems	Immune system	hsa04611	Platelet activation	29/1190	126/9376	1.81341870081366	AKT3/TLN2/VWF/F2R/RASGRP2/PIK3R1/STIM1/PLCG2/ADCY1/MYLK/GNAI1/APBB1IP/ADCY2/PLA2G4A/GP1BB/FYN/ADCY3/PIK3CB/ROCK2/RAP1B/ADCY9/GUCY1B1/P2RX1/AKT2/PIK3CA/P2RY1/MAPK11/ADCY4/RASGRP1	3.50470774014678
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	42/1190	205/9376	1.61423242467719	AKT3/PIK3R1/BCL2/MAPK10/PLCG2/GADD45A/HLA-G/GADD45B/HLA-DRB1/MAP2K3/MYC/HLA-DQB1/HES1/HLA-DPB1/HLA-DRB5/TNFAIP3/HLA-DRA/HLA-DQA1/GADD45G/MAP3K14/NFKBIA/HLA-DPA1/ENTPD3/TRAF5/CD44/STAT3/PIK3CB/OAS2/FAS/JUN/RELA/NEDD4/NFKBIB/CD3E/RUNX3/TRAF6/AKT2/PIK3CA/NCOR2/MAPK11/SIN3A/CCND3	3.3901941583143
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	35/1190	163/9376	1.69180801154818	AKT3/PIK3R1/NFATC1/CREB5/FOS/BCL2/MAPK10/JAK2/EGR3/NFATC2/MAP2K3/MYC/TLR4/SMAD3/STAT5A/CREB3L2/TGFBR2/STAT5B/NFKBIA/TGFBR1/STAT3/PIK3CB/STAT4/PTK2B/HSPG2/FAS/JUN/RELA/TRAF6/TICAM1/AKT2/PIK3CA/CREB3L1/MAPK11/SLC10A1	3.39705127741939
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	18/1190	66/9376	2.14881588999236	NFATC1/RORA/HLA-DRB1/TLR4/HLA-DQB1/HLA-DPB1/HLA-DRB5/IL4R/SMAD3/HLA-DRA/HLA-DQA1/HLA-DPA1/GATA3/STAT3/STAT4/JUN/RELA/IL10	3.57084344452579
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	28/1190	122/9376	1.8082931533269	AKT3/CBLB/PIK3R1/NFATC1/PAK3/FOS/MAPK10/NFATC2/PPP2R3A/MAP3K14/PTPN11/NFKBIA/FYN/PPP2R1B/PPP3CB/PIK3CB/JUN/RELA/PRKCQ/PPP2R5D/NFKBIB/CD3E/AKT2/PIK3CA/MAPK11/IL10/ITK/RASGRP1	3.42615744523728
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	31/1190	140/9376	1.74463385354142	AKT3/SERPINE1/PLAT/ACTA2/GNG4/MRAS/CCN2/ADCY1/PRKAB2/MYLK/GNAI1/PRKCE/SMAD3/ADCY2/GNB5/NOTCH3/MEF2D/MAP1LC3A/TGFBR1/ADCY3/RRAS2/PPARGC1A/EGR1/HDAC4/SLC8A1/ADCY9/RYR3/AKT2/MAP1LC3C/PRKAG2/ADCY4	3.38444983489296
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	45/1190	226/9376	1.56882576039265	AKT3/F2R/PIK3R1/NFATC1/CREB5/PTGER3/FOS/MAPK10/GRIA1/NPR1/OXTR/EDNRA/ADCY1/GNAI1/PLCE1/CRH/ADCY2/CREB3L2/CACNA1C/AFDN/PLN/CAMK2D/FXYD1/NFKBIA/TIAM1/OXT/NPY1R/RAPGEF4/ADCY3/RRAS2/ATP2B4/PIK3CB/PDE10A/JUN/RELA/ROCK2/RAP1B/EDN1/ADCY9/AKT2/PIK3CA/CREB3L1/GLI3/CACNA1D/ADCY4	3.30024496635212
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	17/1190	62/9376	2.16036866359447	TLE2/HES1/CTBP2/NOTCH3/DLL1/NUMBL/TLE6/MAML3/RFNG/ADAM17/KAT2A/DTX1/KAT2B/PSEN1/DTX3/NCOR2/NOTCH4	3.49499829821962
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	49/1190	253/9376	1.52597070448733	FOXO1/AKT3/TLN2/PIK3R1/BCL2/MAPK10/VCL/PLCG2/FOXO3/EGFR/SEPTIN6/FNBP1/TLR4/PRKCE/PLCE1/SEPTIN11/DIAPH1/RIPK2/ITGA5/ACTN4/CGAS/NFKBIA/WASF1/SEPTIN8/IL1R1/FNBP1L/TRAF5/MAP1LC3A/CD44/PIK3CB/NOD1/JUN/CALCOCO2/RELA/ROCK2/BCL2L1/PRKCQ/NFKBIB/CAPN2/TRAF6/AKT2/PIK3CA/ARF1/MAP1LC3C/CAST/UBC/UBE2D1/MAPK11/CYTH3	3.23352503238581
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	34/1190	160/9376	1.67428571428571	NRXN3/NLGN1/NEGR1/ITGB8/NLGN4X/ITGA6/SDC4/SDC2/PTPRM/HLA-G/NRXN2/HLA-DRB1/HLA-DQB1/SDC3/HLA-DPB1/HLA-DRB5/CLDN5/HLA-DRA/HLA-DQA1/LRRC4C/CNTN1/JAM2/NFASC/CLDN4/HLA-DPA1/CDH3/CD2/SDC1/VSIR/CD34/F11R/ESAM/CNTNAP2/JAM3	3.27986497908993
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	43/1190	217/9376	1.56127483251365	AKT3/PGR/AR/PIK3R1/CREB5/FOS/BCL2/ESR1/BCL6/JAK2/GSTM5/EGFR/ADCY1/MYC/RPS6KA2/GNAI1/UGT2B7/VEGFA/STAT5A/ADCY2/CREB3L2/CACNA1C/DLL1/STAT5B/ADCY3/GSTM2/KLF4/STAT3/PIK3CB/JUN/RELA/ADCY9/HSP90AB1/AKT2/PIK3CA/CREB3L1/KPNA5/CCND3/HSP90AA1/CACNA1D/ESR2/ADCY4/KPNA1	3.18936816609296
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1190	29/9376	2.71689365401333	TEAD1/FRMD6/WTIP/FAT4/WWTR1/RASSF2/LATS2/TEAD3/TEAD4/STK3	3.53044558227715
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	26/1190	115/9376	1.78133723054439	AKT3/PIK3R1/CREB5/FOS/BCL2/JAK2/KCNQ3/GNG4/ADCY1/GNAI1/GNAO1/ADCY2/CREB3L2/CACNA1C/GNB5/CAMK2D/FYN/ADCY3/PIK3CB/ADCY9/CHRM5/AKT2/PIK3CA/CREB3L1/CACNA1D/ADCY4	3.21426549109116
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	23/1190	98/9376	1.84915108900703	NR4A1/CREB5/NPR1/CAMK1/ADCY1/PRKCE/ADCY2/CREB3L2/CAMK1G/CACNA1C/CACNA1H/CAMK2D/ADCY3/ATP2B4/DAGLB/AGT/PDE2A/PRKD1/ADCY9/CREB3L1/HSD3B1/CACNA1D/ADCY4	3.22176658907195
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	18/1190	70/9376	2.02602641056423	SGCD/DMD/HLA-G/SSPN/HLA-DRB1/HLA-DQB1/ABL2/HLA-DPB1/HLA-DRB5/CD55/DTNA/HLA-DRA/HLA-DQA1/HLA-DPA1/FYN/CAV1/SNTB2/DAG1	3.28510522200797
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	17/1190	65/9376	2.06065934065934	NR4A1/CREB5/PBX1/PDE8B/ADCY1/ADCY2/CREB3L2/CACNA1C/CACNA1H/PDE8A/ADCY3/AGT/ADCY9/CREB3L1/HSD3B1/CACNA1D/ADCY4	3.27158105523597
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	27/1190	122/9376	1.7437112549938	FOXO1/INSR/IRS2/AKT3/PIK3R1/CREB5/IGF1R/FOXO3/CAB39L/PPARG/TBC1D1/PRKAB2/CREB3L2/PPP2R3A/PFKFB3/CAMKK2/PPP2R1B/PPARGC1A/PIK3CB/IGF1/IRS1/PPP2R5D/ACACB/AKT2/PIK3CA/PRKAG2/CREB3L1	3.1524105368405
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	23/1190	99/9376	1.83047279517868	AKT3/PIK3R1/FOS/IGF1R/BCL2/MAPK10/ESR1/EGFR/ADCY1/ADCY2/NOTCH3/DLL1/ADCY3/PIK3CB/JUN/IGF1/ADCY9/AKT2/PIK3CA/MAPK11/ESR2/NOTCH4/ADCY4	3.16710511765677
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	37/1190	184/9376	1.58436244062843	TRPC4/BOC/PIK3R1/PAK3/ABLIM1/PLCG2/NTN4/ABLIM3/NFATC2/SEMA4A/GDF7/SEMA5A/RGMA/SEMA3C/GNAI1/CXCR4/CXCL12/TRPC6/UNC5C/LRRC4C/CAMK2D/PTPN11/PARD3/FYN/PPP3CB/EPHA4/PIK3CB/NTN1/PLXNA4/ROCK2/RND1/BMPR1B/EPHA6/DPYSL2/SRGAP1/PIK3CA/WNT5A	3.05217511175636
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	42/1190	216/9376	1.53202614379085	AKT3/APOB/MAP3K5/PIK3R1/NFATC1/FOS/BCL2/MAPK10/HSPA6/JAK2/APOA1/PPARG/HSPA1B/NFATC2/MAP2K3/TLR4/ERN1/CYP2A7/HSPA1A/EIF2AK3/CAMK2D/CXCL2/NFKBIA/TNFSF10/PPP3CB/STAT3/PIK3CB/FAS/JUN/RELA/ROCK2/RAP1B/BCL2L1/ABCG1/HSP90AB1/TRAF6/TICAM1/AKT2/PIK3CA/MAPK11/HSP90AA1/ATF6	3.01602794766507
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	22/1190	94/9376	1.8440193098516	FOSB/FOS/MAPK10/JUND/CSF3/FOSL1/TNFAIP3/MAPK6/CXCL2/NFKBIA/TRAF5/IL17D/IL17RE/PTGS2/S100A8/JUN/RELA/HSP90AB1/USP25/TRAF6/MAPK11/HSP90AA1	3.13558642968913
Human Diseases	Infectious disease: viral	hsa05162	Measles	29/1190	136/9376	1.68007909045971	AKT3/CBLB/PIK3R1/FOS/BCL2/MAPK10/HSPA6/HSPA1B/TLR4/TNFAIP3/STAT5A/HSPA1A/STAT5B/NFKBIA/MX2/STAT3/PIK3CB/BBC3/OAS2/FAS/JUN/RELA/BCL2L1/NFKBIB/CD3E/TRAF6/AKT2/PIK3CA/CCND3	3.04590349799611
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	38/1190	193/9376	1.55130404493404	AKT3/CCL21/CCL14/RASGRP2/PIK3R1/PLCG2/JAK2/FOXO3/GNG4/ADCY1/GNAI1/CXCR4/CXCL12/ADCY2/CXCL13/GNB5/STAT5B/PARD3/CXCL2/NFKBIA/TIAM1/ADCY3/STAT3/PIK3CB/GRK4/PTK2B/XCL2/RELA/ROCK2/RAP1B/ADCY9/CCL26/CCL18/NFKBIB/AKT2/PIK3CA/ITK/ADCY4	2.95053513106446
Human Diseases	Cancer: specific types	hsa05218	Melanoma	18/1190	73/9376	1.94276505122597	AKT3/MITF/PDGFD/PIK3R1/IGF1R/GADD45A/PTEN/GADD45B/PDGFRA/EGFR/PDGFRB/FGFR1/GADD45G/PIK3CB/FGF1/IGF1/AKT2/PIK3CA	3.08302213600844
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	34/1190	169/9376	1.58512256973795	IRS2/AKT3/PIK3R1/IGF1R/BCL2/MAPK10/PTEN/GABARAPL1/MRAS/ERN1/CFLAR/DEPTOR/EIF2AK3/CAMKK2/DAPK2/MAP1LC3A/WDR41/UVRAG/RRAS2/DAPK3/PIK3CB/WDFY3/RB1CC1/CALCOCO2/MTMR3/BCL2L1/IRS1/PRKCQ/TRAF6/RUBCN/AKT2/PIK3CA/MAP1LC3C/UBC	2.92653942969444
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	20/1190	86/9376	1.83232362712527	AKT3/CBLB/PIK3R1/PAK3/MAPK10/PLCG2/EGFR/MYC/ABL2/STAT5A/STAT5B/CAMK2D/EREG/PIK3CB/NRG2/JUN/NRG3/AKT2/PIK3CA/CBL	2.95635675219988
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	20/1190	86/9376	1.83232362712527	ITGB8/CACNB2/TCF7L2/SGCD/ITGA6/DMD/SSPN/DES/ITGA1/TCF7L1/DTNA/CACNA1C/ITGA5/SLC8A1/ITGA7/CTNNA3/SNTB2/DAG1/CACNA1D/CACNB1	2.95635675219988
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	22/1190	98/9376	1.76875321557194	INPP4B/PIK3R1/PLCG2/ITPKC/PTEN/ITPKB/IMPA2/PLCE1/PIP5K1C/INPP5A/DGKA/ITPK1/INPP4A/PIK3CB/MTMR3/IP6K3/INPP1/INPP5B/PIK3CA/MTMR1/INPP5F/PIP4K2A	2.91672878623701
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	25/1190	116/9376	1.69805853375833	PIK3R1/VCL/PLCG2/CLDN5/GNAI1/CXCR4/CXCL12/JAM2/AFDN/ACTN4/CLDN4/PTPN11/RAPGEF4/RHOH/PIK3CB/PTK2B/ROCK2/RAP1B/F11R/CTNNA3/ESAM/PIK3CA/JAM3/MAPK11/ITK	2.88428778499139
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	18/1190	75/9376	1.89095798319328	THBS1/SERPINE1/IGFBP3/BCL2/SESN1/GADD45A/PTEN/ZNF385A/GADD45B/RPRM/GADD45G/PPP1R13L/BBC3/FAS/IGF1/BCL2L1/SESN3/CCND3	2.95356329209956
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	23/1190	105/9376	1.7258743497399	CCL21/BCL2/PLCG2/GADD45A/GADD45B/TLR4/CXCL12/TNFAIP3/CFLAR/TRAF1/GADD45G/MAP3K14/PPP1R13L/CXCL2/NFKBIA/IL1R1/TRAF5/PTGS2/RELA/BCL2L1/PRKCQ/TRAF6/TICAM1	2.85178025487724
Human Diseases	Cancer: specific types	hsa05214	Glioma	18/1190	76/9376	1.86607695709863	AKT3/PIK3R1/IGF1R/PLCG2/GADD45A/PTEN/GADD45B/PDGFRA/EGFR/CAMK1/PDGFRB/CAMK1G/GADD45G/CAMK2D/PIK3CB/IGF1/AKT2/PIK3CA	2.89031418619138
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	20/1190	88/9376	1.79067990832697	CFH/SERPINE1/VWF/F2R/MASP1/PLAT/SERPING1/C7/TFPI/SERPINC1/F10/CD55/C5AR1/KNG1/F2RL2/PLG/A2M/SERPINF2/VSIG4/SERPINA1	2.84121556170475
NA	NA	hsa04081	Hormone signaling	41/1190	219/9376	1.47506235370861	INSR/IRS2/ADRA2C/PRLR/PIK3R1/IGF1R/ESR1/JAK2/NPR1/AVPR1A/OXTR/GNG4/HEPH/RAMP1/ADCY1/GHR/GNAI1/GNAO1/RAMP3/CSH2/CRH/STAT5A/ADCY2/DIO2/GNB5/STAT5B/OXT/IGF2/RAPGEF4/SMAD1/ADCY3/STAT3/PIK3CB/AGT/IGF1/ADCY9/IRS1/BMPR1B/PIK3CA/ESR2/ADCY4	2.7121850342066
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	15/1190	60/9376	1.96974789915966	AKT3/PIK3R1/PLCG2/SH2D2A/NFATC2/MAPKAPK2/VEGFA/HSPB1/PLA2G4A/PPP3CB/PTGS2/PIK3CB/AKT2/PIK3CA/MAPK11	2.87304865903451
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	18/1190	77/9376	1.84184219142202	AKT3/PIK3R1/MAPK10/GADD45A/GADD45B/EGFR/VEGFA/SMAD3/TGFBR2/GADD45G/TGFBR1/STAT3/PIK3CB/ARHGEF6/RELA/BCL2L1/AKT2/PIK3CA	2.82801152746056
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	26/1190	125/9376	1.63883025210084	AKT3/CERS6/MAP3K5/PIK3R1/BCL2/MAPK10/PTEN/GAB2/SGMS2/CERS4/GNAI1/S1PR3/PRKCE/PPP2R3A/KNG1/SPTLC2/FYN/PPP2R1B/ACER2/PIK3CB/RELA/ROCK2/PPP2R5D/AKT2/PIK3CA/MAPK11	2.74138094003564
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	18/1190	78/9376	1.81822882999354	FOS/JAK2/HLA-DRB1/TLR4/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/NFKBIA/HLA-DPA1/PTGS2/JUN/RELA/NFKBIB/TRAF6/MAPK11/IL10	2.76662665486697
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	13/1190	50/9376	2.04853781512605	IL15/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/CXCR4/CXCL12/HLA-DRA/HLA-DQA1/MAP3K14/HLA-DPA1/IL10/IL15RA	2.83429234032186
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	37/1190	196/9376	1.48736065854913	AKT3/ZFP36/TCF7L2/PIK3R1/NFATC1/FOS/MAPK10/PLCG2/JAK2/HLA-G/GNG4/NFATC2/MYC/MAPKAPK2/TCF7L1/VEGFA/ANGPT2/CLEC2B/GNB5/CXCL2/NFKBIA/MAP1LC3A/PPP3CB/RCAN1/PTGS2/STAT3/PIK3CB/IL6ST/FAS/JUN/RELA/TICAM1/AKT2/PIK3CA/MAP1LC3C/UBC/MAPK11	2.62893841373577
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	24/1190	115/9376	1.64431128973328	AKAP13/CREB5/FOS/BCL2/JUND/EGFR/ADCY1/GNAI1/FGFR1/ADCY2/CREB3L2/MMP17/GATA3/MEF2D/SGK1/ADCY3/EGR1/ADCY9/LRP5/GCM1/CREB3L1/WNK1/ADCY4/WNK2	2.65056810702235
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	21/1190	97/9376	1.70576106731352	FOS/GRIA1/GNG4/ADCY1/PER2/GNAI1/GNAO1/ADCY2/CACNA1C/GNB5/CACNA1H/CAMK2D/PER1/ADCY3/ADCY9/RYR3/GUCY1B1/PER3/RASD1/CACNA1D/ADCY4	2.66388962079435
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1190	68/9376	1.85388037567968	ZBTB16/AKT3/TCF7L2/PIK3R1/PIM1/PER2/MYC/TCF7L1/STAT5A/STAT5B/STAT3/PIK3CB/RELA/RARA/AKT2/PIK3CA	2.69430371716243
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	30/1190	154/9376	1.53486849285169	AKT3/CACNB2/CREB5/BCL2/SCN7A/ADCY1/TPM1/GNAI1/ADCY2/CREB3L2/CACNA1C/PPP2R3A/PLN/CAMK2D/RAPGEF4/TNNT2/PPP2R1B/ADCY3/ATP2B4/AGT/SLC8A1/ADCY9/PPP2R5D/AKT2/CREB3L1/MAPK11/KCNE1/CACNA1D/CACNB1/ADCY4	2.55163215375132
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	13/1190	52/9376	1.96974789915966	INSR/IGF1R/ADCY1/BMP6/ADCY2/PLA2G4A/ADCY3/PTGS2/IGF1/ADCY9/HSD17B2/HSD3B1/ADCY4	2.673515064452
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	30/1190	155/9376	1.52496611547845	TCF7L2/NR4A1/CREB5/PBX1/PDE8B/EGFR/ADCY1/GNAI1/TCF7L1/CRH/ADCY2/CREB3L2/CACNA1C/CACNA1H/FZD8/CAMK2D/PDE8A/WNT9A/ADCY3/AGT/RAP1B/ADCY9/AXIN1/RASD1/CREB3L1/HSD3B1/WNT2B/CACNA1D/ADCY4/WNT5A	2.51264630545507
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	41/1190	227/9376	1.42307777736645	AKT3/AKAP13/PIK3R1/NFATC1/CREB5/PTGER3/HLA-G/GNG4/PDGFRA/EGFR/ADCY1/NFATC2/MYC/GNAI1/CXCR4/GNAO1/CXCL12/VEGFA/IL6R/ADCY2/CREB3L2/GNB5/CGAS/NFKBIA/IL1R1/TRAF5/PPP3CB/ADCY3/PTGS2/STAT3/PIK3CB/PTK2B/FAS/RELA/ROCK2/ADCY9/AKT2/PIK3CA/CREB3L1/MAPK11/ADCY4	2.46019526141077
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/1190	21/9376	2.62633053221288	CHST7/UST/CHST11/XYLT1/CHST3/CHSY3/CHSY1	2.84459089476412
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	12/1190	47/9376	2.01165742892902	INSR/IRS2/PIK3R1/MAPK10/PRKCE/CACNA1C/SOCS2/SOCS3/PIK3CB/IRS1/PIK3CA/CACNA1D	2.65086802221202
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	44/1190	248/9376	1.39788560585525	AKT3/TCF7L2/RHOB/PAK3/FOS/BCL2/MAPK10/RHOJ/DYNC2LI1/MAP2K3/MYC/TLR4/MYO6/TCF7L1/AHNAK/RIPK2/PODXL/NFKBIA/TNFSF10/ACTR1B/CYFIP2/SNX9/RHOH/PIK3CB/NOD1/DYNC1I2/JUN/RELA/TUBA1A/ROCK2/DYNC2H1/HSP90AB1/FYCO1/WASF3/TRAF6/AKT2/PIK3CA/ARF1/ABI1/PLEKHM2/MAPK11/CYTH3/HSP90AA1/KPNA1	2.42113776321555
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	28/1190	144/9376	1.53202614379085	AKT3/PIK3R1/IGF1R/ID4/JAK2/LEFTY2/ZFHX3/MYC/FGFR1/SMAD3/TBX3/FZD8/WNT9A/SMAD1/LIFR/KLF4/STAT3/PIK3CB/IL6ST/IGF1/BMPR1B/AXIN1/ACVR1B/AKT2/PIK3CA/MAPK11/WNT2B/WNT5A	2.45295494297314
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	28/1190	144/9376	1.53202614379085	FOXO1/AKT3/TCF7L2/MAP3K5/NOX4/MAPK10/FOXO3/MAP2K3/TLR4/PRKAB2/TCF7L1/LPIN1/ALDH7A1/C5AR1/ADH1B/MAP3K14/CAMKK2/CXCL2/NFKBIA/PPARGC1A/FAS/RELA/TRAF6/TICAM1/ACACB/AKT2/PRKAG2/MAPK11	2.45295494297314
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	27/1190	138/9376	1.54154183412495	AKT3/PIK3R1/NFATC1/FOS/MAPK10/WIPF3/NFATC2/MAP2K3/TLR4/RPS6KA2/ITGA5/PIP5K1C/NFKBIA/ARHGEF28/ARHGEF7/PIK3CB/PTK2B/JUN/RELA/WIPF1/ROCK2/TRAF6/TICAM1/AKT2/PIK3CA/MAPK11/IL10	2.44346332279721
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16/1190	71/9376	1.77554740205942	MAPK10/PLCG2/EGFR/ATP6V0A1/JAM2/MAP3K14/PTPN11/CXCL2/NFKBIA/ADAM17/NOD1/JUN/RELA/F11R/JAM3/MAPK11	2.50093602101619
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	6/1190	17/9376	2.78082056351953	GLUL/CA8/GLUD1/CA5B/CPS1/CA13	2.80190333211357
Human Diseases	Immune disease	hsa05310	Asthma	9/1190	32/9376	2.21596638655462	PRG2/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DPA1/IL10	2.62695959346302
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	21/1190	103/9376	1.60639634494575	COL12A1/COL4A1/COL18A1/COL4A2/COL6A3/SLC38A2/COL4A4/SLC7A8/COL5A3/COL4A3/XPNPEP2/ACE2/COL16A1/CPB1/COL27A1/COL24A1/COL17A1/SLC8A1/COL26A1/MME/COL11A1	2.35932791458598
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	21/1190	103/9376	1.60639634494575	COL4A1/COL4A2/LAMB1/PIK3R1/VCL/COL4A4/ADCY1/TLR4/LAMA3/COL4A3/HSPB1/ACTN4/GNAL/CXCL2/IL1R1/PIK3CB/RELA/IL1R2/PIK3CA/LAMC3/IL10	2.35932791458598
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	36/1190	200/9376	1.41821848739496	LPAR1/MYH11/F2R/PAK3/FOS/MAPK10/WIPF3/MYO1E/TLR4/MYO6/CLDN5/MYO1D/CLDN4/PTPN11/NFKBIA/WASF1/FYN/IL1R1/TNFSF10/CYFIP2/MYO5C/FAS/JUN/RELA/TUBA1A/WIPF1/ROCK2/NFKBIB/WASF3/TRAF6/ARF1/ABI1/MAPK11/CYTH3/MYH9/SEC24A	2.27936970122451
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	27/1190	142/9376	1.49811812048763	AKT3/DUSP1/MAP3K5/PIK3R1/FOS/PLAT/BCL2/MAPK10/SDC4/SDC2/GSTM5/VEGFA/IL1R1/CAV1/GSTM2/PIK3CB/SDC1/JUN/RELA/EDN1/BMPR1B/HSP90AB1/IL1R2/AKT2/PIK3CA/MAPK11/HSP90AA1	2.28036741488908
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/1190	23/9376	2.39795396419437	ACE/REN/ACE2/ENPEP/NLN/AGT/MME	2.5592020180545
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/1190	39/9376	2.02025425554837	HLA-G/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DPA1/FAS/IL10	2.43422258629068
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	20/1190	99/9376	1.59171547406842	AKT3/PDGFD/PIK3R1/FOS/MAPK10/PDGFRA/EGFR/PDGFRB/PLPP1/GPCPD1/PIP5K1C/DGKA/PLA2G4A/SLC44A2/WASF1/PIK3CB/JUN/WASF3/AKT2/PIK3CA	2.25657615396731
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	26/1190	138/9376	1.48444769212033	FOXO1/INSR/IRS2/AKT3/CBLB/SORBS1/PIK3R1/MAPK10/PRKAR2B/PRKAB2/INPP5A/PYGM/RHOQ/SOCS2/SOCS3/PTPN1/PPARGC1A/PIK3CB/PPP1R3B/RAPGEF1/IRS1/ACACB/AKT2/PIK3CA/PRKAG2/CBL	2.18585175311985
Organismal Systems	Endocrine system	hsa04924	Renin secretion	15/1190	69/9376	1.71282426013884	PDE1A/NPR1/ACE/EDNRA/GNAI1/REN/CACNA1C/KCNMA1/PPP3CB/AGT/AQP1/EDN1/PDE1C/GUCY1B1/CACNA1D	2.26582001679296
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	15/1190	70/9376	1.68835534213685	AKT3/PIK3R1/PAK3/EGLN3/VEGFA/ETS1/PTPN11/PIK3CB/JUN/EPAS1/RAP1B/RAPGEF1/AKT2/PIK3CA/TFE3	2.20395859772005
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	19/1190	95/9376	1.57579831932773	FLT1/IL15/FOS/CTSK/HLA-DRB1/TLR4/HLA-DQB1/HLA-DPB1/HLA-DRB5/CXCL12/VEGFA/HLA-DRA/HLA-DQA1/ATP6V0A1/CXCL2/TEK/HLA-DPA1/JUN/ACP5	2.15059215853656
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	31/1190	173/9376	1.4118424248312	AKT3/PIK3R1/JAK2/DNAJB1/HLA-DRB1/TLR4/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/PLG/NFKBIA/HLA-DPA1/SOCS3/TNFSF10/MX2/PIK3CB/OAS2/FAS/CALCOCO2/RELA/NUP98/NFKBIB/TICAM1/AKT2/PIK3CA/CIITA/KPNA5/CCND3/KPNA1	2.08455170383737
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	18/1190	89/9376	1.5935039184213	GLUL/PLCL1/SLC38A2/GNG4/GABARAPL1/GPHN/ADCY1/GNAI1/GNAO1/ADCY2/CACNA1C/GNB5/ADCY3/GABRB3/ADCY9/CACNA1D/GLS/ADCY4	2.14488553258987
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	9/1190	36/9376	1.96974789915966	GALNT13/GALNT15/ST6GALNAC2/GALNT17/ST6GALNAC3/B4GALT5/GALNT16/GCNT1/GALNT7	2.22259282713815
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	42/1190	250/9376	1.32367058823529	CBLB/IGF1R/HSPA6/HLA-G/WIPF3/HSPA1B/PDGFRA/EGFR/ASAP1/RAB11FIP3/ACAP1/CXCR4/SMAD3/EPN2/EHD1/TGFBR2/HSPA1A/PIP5K1C/WASHC2A/ASAP3/ASAP2/PARD3/AMPH/CAV1/TGFBR1/AP2B1/TFRC/GRK4/CHMP4B/WIPF1/SPART/AGAP3/NEDD4/EEA1/SMURF1/WASHC1/RAB11FIP1/TRAF6/DNM3/ARF1/CYTH3/CBL	1.97768107632406
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	16/1190	78/9376	1.6162034044387	PIK3R1/VCL/SEPTIN6/SEPTIN1/ARHGAP10/SEPTIN11/ITGA5/WASF1/SEPTIN8/CAV1/PIK3CB/CTNNA3/DNM3/CD2AP/PIK3CA/CBL	2.08353054921487
Human Diseases	Substance dependence	hsa05032	Morphine addiction	18/1190	91/9376	1.55848185428017	PDE1A/PDE8B/GNG4/ADCY1/GNAI1/GNAO1/ADCY2/GNB5/PDE8A/ADCY3/PDE10A/GRK4/PDE7A/PDE2A/GABRB3/ADCY9/PDE1C/ADCY4	2.04108954345968
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	30/1190	170/9376	1.39041028175976	MYH11/MAP3K5/MAPK10/TJP2/PRKAB2/CLDN5/PRKCE/YBX3/DLG2/JAM2/AFDN/ACTN4/CLDN4/LLGL2/PARD3/TIAM1/PPP2R1B/RAB8B/AMOT/JUN/TUBA1A/ROCK2/F11R/RAPGEF2/NEDD4/PRKAG2/JAM3/CACNA1D/MYH9/EPB41L4B	1.95854462266585
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1190	98/9376	1.52755959526668	AKT3/PIK3R1/PLCG2/GSN/GAB2/ASAP1/PRKCE/PLPP1/PIP5K1C/ASAP3/ASAP2/PLA2G4A/WASF1/AMPH/PLA2G6/PIK3CB/WASF3/AKT2/PIK3CA	2.00161537773219
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/1190	37/9376	1.91651146945265	TCF7L2/NTRK1/GADD45A/GADD45B/PPARG/MYC/TCF7L1/GADD45G/CCDC6	2.12966761732005
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	7/1190	26/9376	2.12126696832579	APOB/APOA1/SLC19A2/CUBN/TCN2/BTD/SLC19A3	2.18279598182392
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/1190	61/9376	1.6791293566607	TF/MT1G/HEPH/MT1H/MT1M/SLC30A1/MT1A/CYBRD1/SLC26A6/ATP2B4/MT1F/SLC8A1/SLC26A3	2.02884673644506
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	36/1190	214/9376	1.32543783868688	AKT3/PIK3R1/NFATC1/PAK3/FOS/BCL2/MAPK10/PLCG2/HLA-G/SAMHD1/GNG4/NFATC2/MAP2K3/TLR4/WEE1/GNAI1/CXCR4/GNAO1/GNB5/CGAS/NFKBIA/DCAF1/TRAF5/PPP3CB/AP1M1/PIK3CB/PTK2B/FAS/JUN/RELA/BCL2L1/CD3E/TRAF6/AKT2/PIK3CA/MAPK11	1.83612836051028
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	10/1190	44/9376	1.79067990832697	HLA-G/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DPA1/FAS/PTPRN2	2.0043009169806
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	11/1190	50/9376	1.7333781512605	THBS1/SDC2/THBS3/CSF3/TLR4/HBA2/THBS4/HBA1/SDC1/COMP/IL10	1.9823873270867
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	31/1190	180/9376	1.35693744164332	AKT3/PIK3R1/BCL2/PILRA/JAK2/HLA-G/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/ITGA5/PTPN11/CGAS/NFKBIA/HLA-DPA1/SOCS3/TRAF5/PIK3CB/OAS2/FAS/RELA/ZC3HAV1/BCL2L1/CD74/CARD9/TRAF6/TICAM1/AKT2/PIK3CA	1.84353813818356
NA	NA	hsa04519	Cadherin signaling	63/1190	404/9376	1.2286546301689	CDH13/LHFPL3/TEAD1/TCF7L2/IGF1R/MAPK10/VCL/PRICKLE2/DAAM1/PDGFRA/EGFR/MYO1E/MRAS/MAP2K3/DES/PDGFRB/TCF7L1/LHFPL6/LIMA1/FGFR1/FLT4/PCDH19/KRT5/WTIP/AFDN/ACTN4/FAT4/MYO1D/FZD8/WWTR1/NFKBIA/WNT9A/WASF1/KRT8/CYFIP2/RRAS2/SCN3B/CDH3/KRT18/PTK2B/SHOC2/RELA/LATS2/ROCK2/GABRB3/PCDHB2/TMC1/PSEN1/ERBIN/KRT7/LRP5/AXIN1/CDH11/CTNNA3/PCDH17/PCDHB16/TEAD3/TEAD4/MAPK11/ANKRD6/STK3/WNT2B/WNT5A	1.79122152273877
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	32/1190	187/9376	1.34827663685795	TXNIP/BCL2/MAPK10/GBP2/GABARAPL1/TLR4/ANTXR2/TNFAIP3/RIPK2/GBP1/CXCL2/NFKBIA/TRAF5/MAP1LC3A/CARD18/NOD1/OAS2/JUN/RELA/BCL2L1/ERBIN/HSP90AB1/NFKBIB/MCU/CARD9/TRAF6/TICAM1/MAP1LC3C/MAPK11/HSP90AA1/GBP4/NEK7	1.83414754259341
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	48/1190	298/9376	1.26909931757938	IL1RL1/CCL21/IL15/CCL14/PRLR/NGF/CSF3/ACVRL1/CLCF1/GDF7/GHR/ACKR4/CXCR4/BMP6/CXCL12/CSH2/IL4R/IL6R/TGFBR2/CXCL13/IL1RL2/TNFRSF8/CXCL2/IL19/IL1R1/TNFSF10/TGFBR1/IL17D/IL1RAP/IL17RE/RELL1/LIFR/IL34/IL6ST/XCL2/NGFR/FAS/CCL26/CCL18/IL7/BMPR1B/IL7R/IL1R2/ACVR1B/INHA/IL10/EBI3/IL15RA	1.79990211793949
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	19/1190	101/9376	1.48218653798153	MITF/TCF7L2/ADCY1/ASIP/GNAI1/GNAO1/TCF7L1/ADCY2/CREB3L2/FZD8/CAMK2D/WNT9A/ADCY3/EDN1/ADCY9/CREB3L1/WNT2B/ADCY4/WNT5A	1.85755660906571
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	16/1190	82/9376	1.53736421397827	HSPA6/HLA-G/HSPA1B/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/HSPA1A/HLA-DPA1/CD74/HSP90AB1/CIITA/HSP90AA1/NFYB	1.86336349014519
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/1190	39/9376	1.81822882999354	DMGDH/ALDH1L2/BHMT2/MTR/ALDH7A1/AMT/MTHFD2/MAT2B/CTH	1.95221052780997
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	10/1190	45/9376	1.75088702147526	ABCA8/ABCA9/ABCD2/ABCA6/ABCA5/ABCB1/ABCB5/ABCC9/ABCG1/ABCA3	1.92504111168176
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	23/1190	128/9376	1.41575630252101	PDE1A/NPR1/PRPS2/PDE8B/ADA/ADCY1/ADCY2/AMPD3/PDE8A/ENTPD3/PDE5A/ADCY3/PDE10A/PDE7A/PDE2A/ADCY9/ADK/GDA/PDE1C/GUCY1B1/ENTPD6/ADA2/ADCY4	1.80568988194559
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	25/1190	142/9376	1.38714640785892	CBLB/KLHL13/UBE2G2/UBE2H/UBE2E2/SOCS3/ANAPC7/HERC3/MID1/FBXW7/HERC1/PRKN/UBE2Q2/FANCL/NEDD4/UBE2E1/SMURF1/TRAF6/UBE2G1/UBC/UBR5/UBE2D1/MGRN1/UBE2R2/CBL	1.77234277767005
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	22/1190	122/9376	1.42080176332828	FOXO1/AKT3/PIK3R1/ESR1/PLCG2/MED13L/NCOA1/MYC/PLCE1/DIO2/NOTCH3/PLN/RCAN1/RCAN2/KAT2A/PIK3CB/KAT2B/MED12L/AKT2/PIK3CA/SIN3A/NOTCH4	1.78367599485663
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	21/1190	116/9376	1.426369168357	GLUL/SLC38A2/GRIA1/HOMER1/GNG4/ADCY1/GNAI1/GNAO1/SHANK2/ADCY2/CACNA1C/GRM7/GNB5/PLA2G4A/PPP3CB/ADCY3/ADCY9/GRIK2/CACNA1D/GLS/ADCY4	1.76170238556925
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	29/1190	170/9376	1.34406327236777	AKT3/TCF7L2/PIK3R1/IGF1R/PLCG2/GADD45A/PTEN/GADD45B/GSTM5/EGFR/MYC/TCF7L1/SMAD3/TGFBR2/GADD45G/FZD8/WNT9A/IGF2/TGFBR1/SMARCA2/GSTM2/PIK3CB/BCL2L1/LRP5/AXIN1/AKT2/PIK3CA/WNT2B/WNT5A	1.72603874292269
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	26/1190	150/9376	1.3656918767507	AKT3/TCF7L2/PIK3R1/BCL2/GADD45A/GADD45B/EGFR/MYC/TCF7L1/SMAD3/TGFBR2/GADD45G/FZD8/WNT9A/ABCB1/TGFBR1/PIK3CB/MLH1/FGF1/LRP5/AXIN1/CTNNA3/AKT2/PIK3CA/WNT2B/WNT5A	1.72138282869188
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	14/1190	71/9376	1.55360397680199	AKT3/NTRK1/PIK3R1/PTEN/PDGFRA/EGFR/MYC/PDGFRB/FGFR1/PIK3CB/NTRK3/AKT2/PIK3CA/GLS	1.78522695490357
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	27/1190	157/9376	1.35498581598244	THBS1/MFGE8/NFATC1/PBX1/JAK2/PPARG/GULP1/AXL/NFATC2/MAPKAPK2/DUSP2/ATP8A2/DUSP16/CAMK2D/PTPN11/ANO3/SGK1/ADAM17/DUSP8/PLA2G6/PTGS2/ATP11C/MERTK/MAPK11/ANO4/ATP11B/IL10	1.71018135754846
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	20/1190	110/9376	1.43254392666157	AKT3/PGR/PIK3R1/IGF1R/MAPK10/ADCY1/RPS6KA2/GNAI1/ADCY2/ANAPC7/ADCY3/PIK3CB/IGF1/ADCY9/HSP90AB1/AKT2/PIK3CA/MAPK11/HSP90AA1/ADCY4	1.73981736769312
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	19/1190	105/9376	1.42572228891557	MITF/MAPK10/FOXO3/GABARAPL1/MRAS/CITED2/EIF2AK3/MAP1LC3A/RRAS2/RABGEF1/PRKN/JUN/CALCOCO2/RELA/BCL2L1/SMURF1/MAP1LC3C/UBC/TFE3	1.67255726562812
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	16/1190	86/9376	1.46585890170021	CREB5/KCNMB1/ADCY1/ADCY2/CREB3L2/CACNA1C/RIMS2/KCNMA1/CAMK2D/RAPGEF4/ADCY3/TRPM4/ADCY9/CREB3L1/CACNA1D/ADCY4	1.65469904341256
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/1190	73/9376	1.51103948428687	AKT3/PIK3R1/PLCG2/FOXO3/GADD45A/GADD45B/EGFR/STAT5A/GADD45G/STAT5B/STAT3/PIK3CB/AKT2/PIK3CA	1.67119691208526
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	23/1190	133/9376	1.3625323813736	AKT3/MAOB/CREB5/FOS/MAPK10/GRIA1/GNG4/GNAI1/GNAO1/CREB3L2/CACNA1C/PPP2R3A/GNB5/CAMK2D/GNAL/PPP2R1B/PPP3CB/LRTOMT/PPP2R5D/AKT2/CREB3L1/MAPK11/CACNA1D	1.60542268921325
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	17/1190	93/9376	1.44024577572965	MAPK10/EGFR/ADCY1/MAP2K3/MAP3K4/ADCY2/CACNA1C/PLA2G4A/CAMK2D/ADCY3/EGR1/PTK2B/JUN/ADCY9/MAPK11/CACNA1D/ADCY4	1.62673100880526
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	14/1190	75/9376	1.47074509803922	AKT3/MAP3K5/PIK3R1/BCL2/REV3L/GSTM5/GSTM2/PIK3CB/MLH1/BBC3/FAS/BCL2L1/AKT2/PIK3CA	1.56053985455206
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1190	69/9376	1.48444769212033	MAOB/FOSB/CREB5/FOS/GRIA1/ARC/CREB3L2/CACNA1C/CAMK2D/PPP3CB/JUN/CREB3L1/CACNA1D	1.53989046007159
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	12/1190	63/9376	1.50076030412165	TCF7L2/GADD45A/GADD45B/TCF7L1/GADD45G/FZD8/WNT9A/AXIN1/GLI3/PTCH2/WNT2B/WNT5A	1.52047266389829
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	9/1190	44/9376	1.61161191749427	CREB5/DYNC2LI1/CREB3L2/ADCY3/DYNC1I2/ADCY9/DYNC2H1/AQP3/CREB3L1	1.55038001365668
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1190	20/9376	1.96974789915966	UGP2/UAP1/UGDH/GMDS/GNE	1.65520575412105
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	29/1190	181/9376	1.2623798690747	AKT3/BCL2/MAPK10/JAK2/PLK3/HLA-DRB1/TLR4/HLA-DQB1/PLA2R1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/ATP6V0A1/RIPK2/KSR1/CAMK2D/HLA-DPA1/PPP3CB/RELA/CD74/EEA1/CARD9/TRAF6/AKT2/CIITA/MAPK11/IL10/NFYB	1.35899287691541
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	16/1190	91/9376	1.3853172038046	AKT3/IFITM1/PIK3R1/NFATC1/FOS/PLCG2/NFATC2/DAPP1/NFKBIA/PPP3CB/PIK3CB/JUN/RELA/NFKBIB/AKT2/PIK3CA	1.40822286270046
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	28/1190	174/9376	1.26788370520622	MAP3K5/BCL2/MAPK10/HSPA6/HSPA1B/CRYAB/DNAJB1/ERN1/PPP1R15A/WFS1/HSPA1A/HSPH1/UBE2G2/EIF2AK3/BAG2/PRKN/UBXN2A/HSP90AB1/DNAJC1/CAPN2/RNF185/UBE2G1/UBE2D1/TXNDC5/HSP90AA1/ATF6/BCAP29/SEC24A	1.35988773119577
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	9/1190	45/9376	1.57579831932773	HLA-G/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DPA1/FAS	1.47616805863207
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/1190	78/9376	1.41417797888386	FOS/MAPK10/SERPING1/TLR4/GNAI1/IRF1/ITGA5/NOD1/JUN/RELA/TRAF6/TICAM1/MAPK11/IL10	1.40043444356278
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	10/1190	52/9376	1.51519069166128	APOA2/APOC3/APOB/OSBPL5/APOA1/APOC2/APOH/LPL/SORT1/SOAT1	1.42033829247317
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/1190	54/9376	1.45907251789605	HLA-G/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/HLA-DPA1/FAS/IL10	1.28987276847437
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/1190	41/9376	1.53736421397827	MAOB/AOC3/DMGDH/ALDH7A1/AMT/SDS/PSPH/CTH	1.31470028468203
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/1190	75/9376	1.3656918767507	GPX3/ALB/CREB5/TTR/ADCY1/ADCY2/CREB3L2/TTF2/ADCY3/ADCY9/DUOX1/CREB3L1/ADCY4	1.21228399516519
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	15/1190	89/9376	1.32791993201775	LPAR1/PDGFD/PDGFRA/EGFR/ADCY1/PDGFRB/HTR2A/GNAI1/HTR2B/ADCY2/ADCY3/TUBA1A/ADCY9/GUCY1B1/ADCY4	1.18508184394741
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1190	42/9376	1.50076030412165	TF/SAT1/ACSL1/GCLC/CP/MAP1LC3A/TFRC/MAP1LC3C	1.24006340151272
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	12/1190	69/9376	1.37025940811107	AKT3/PIK3R1/MAPK10/PLCG2/GAB2/MAP2K3/PLA2G4A/FYN/PIK3CB/AKT2/PIK3CA/MAPK11	1.17692568171091
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1190	17/9376	1.85388037567968	CYP7B1/BAAT/HSD3B7/SLC27A5	1.34347632706739
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/1190	17/9376	1.85388037567968	BAAT/GGT5/CSAD/CDO1	1.34347632706739
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1190	17/9376	1.85388037567968	MYH11/TFRC/DAG1/MYH9	1.34347632706739
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/1190	56/9376	1.40696278511405	BOC/BCL2/GAS1/EVC2/HHAT/CSNK1G3/SMURF1/GLI3/MGRN1/PTCH2	1.16456572197832
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	10/1190	56/9376	1.40696278511405	HSPA6/HSPA1B/TLR4/HSPA1A/CXCL2/NFKBIA/CLK1/RELA/ARF1/HSF1	1.16456572197832
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	7/1190	37/9376	1.4906200317965	UGP2/UAP1/UGDH/GNPNAT1/GMDS/PMM2/GNE	1.14003766341249
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/1190	37/9376	1.4906200317965	APOA1/HBA2/KNG1/APOL1/HBA1/FAS/IL10	1.14003766341249
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/1190	85/9376	1.29771626297578	ADA/UCK2/AMPD3/CTPS1/ENTPD3/CDA/UPP1/ADK/GDA/ENTPD6/UPP2/CMPK1/ADA2/CTPS2	1.05124523559073
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	16/1190	100/9376	1.26063865546218	CCL21/CCL14/ACKR4/CXCR4/CXCL12/IL6R/CXCL13/CXCL2/IL19/TNFSF10/IL34/IL6ST/XCL2/CCL26/CCL18/IL10	0.999037304698092
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1190	38/9376	1.45139318885449	INSR/PIK3R1/SGK1/PIK3CB/IGF1/IRS1/PIK3CA	1.06302410808839
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/1190	59/9376	1.33542230451503	UCK2/DPYD/CTPS1/ENTPD3/CDA/UPP1/ENTPD6/UPP2/CMPK1/CTPS2	0.985378643143955
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	12/1190	73/9376	1.29517670081731	ELL2/SAMHD1/CXCR4/MAP1B/ELL/NUP153/MX2/KAT2A/CHMP4B/MDFIC/KAT2B/CPSF6	0.965284300123671
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	23/1190	155/9376	1.16914068853348	THBS1/HLA-G/THBS3/HLA-DRB1/STX18/TLR4/HLA-DQB1/PLA2R1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/ATP6V0A1/ITGA5/HLA-DPA1/TFRC/THBS4/DYNC1I2/TUBA1A/COMP/DYNC2H1/EEA1/STX12	0.809558395513655
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/1190	54/9376	1.31316526610644	BHMT2/MTR/GCLC/KYAT1/SDS/MAT2B/AMD1/CTH/CDO1	0.87991185060265
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1190	76/9376	1.24405130473242	APOA2/APOC3/SORBS1/APOA1/PPARG/FABP4/ME3/ACSL1/FABP5/SLC27A5/LPL/UBC	0.814459895792259
Cellular Processes	Cell motility	hsa04814	Motor proteins	28/1190	194/9376	1.13717404487568	ACTG2/MYH11/ACTA2/KIF13B/DYNC2LI1/MYO1E/KIF21A/MYO16/MYO6/TPM1/KIF16B/MYO9B/MYO1D/DNAH11/KIFAP3/STARD9/ACTR1B/TNNT2/MYO5C/DYNC1I2/TUBA1A/MYO3B/DYNC2H1/DNAH7/MYO9A/MYO18B/KIF27/MYH9	0.736084062218446
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	23/1190	157/9376	1.15424717657764	INSR/IRS2/AKT3/MAP3K5/PIK3R1/FOS/MAPK10/COX7A1/PPARG/PRKAB2/ERN1/IL6R/EIF2AK3/SOCS3/PIK3CB/FAS/JUN/RELA/IRS1/AKT2/PIK3CA/PRKAG2/MAPK11	0.743101932418075
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	23/1190	158/9376	1.14694181470056	INSR/AKT3/PIK3R1/IGF1R/CAB39L/PTEN/RPS6KA2/CLIP1/LPIN1/DEPTOR/FZD8/WNT9A/SGK1/PIK3CB/RNF152/IGF1/IRS1/LRP5/GRB10/AKT2/PIK3CA/WNT2B/WNT5A	0.710197009615909
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/1190	49/9376	1.28636597496141	GALNT13/GALNT15/GALNT17/EOGT/FUT10/GALNT16/RFNG/GALNT7	0.766252166887002
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1190	49/9376	1.28636597496141	MAOB/FOSB/CREB5/GNAI1/CREB3L2/JUN/RELA/CREB3L1	0.766252166887002
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/1190	42/9376	1.31316526610644	MAOB/AOX1/AOC1/ALDH7A1/KYAT1/KMO/AADAT	0.775510322857484
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	29/1190	205/9376	1.11458905513425	PIK3R1/CREB5/HLA-G/GSN/EGR3/MAPKAPK2/STAT5A/CREB3L2/TRAF1/ACTN4/STAT5B/NFKBIA/HDAC7/TRAF5/KAT2A/STAT3/PIK3CB/IL6ST/RASA2/REL/JUN/RELA/HDAC4/KAT2B/SRF/HDAC11/PIK3CA/CREB3L1/CCND3	0.632462777469054
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1190	15/9376	1.57579831932773	ST6GALNAC5/ST6GALNAC3/ST6GALNAC6	0.850899265062813
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	24/1190	168/9376	1.12557022809124	GLUL/BCL2/MAPK10/JAK2/TLR4/TNFAIP3/STAT5A/CFLAR/PYGM/PLA2G4A/STAT5B/CAMK2D/SPATA2L/TNFSF10/TRAF5/STAT3/CHMP4B/STAT4/FAS/GLUD1/HSP90AB1/CAPN2/TICAM1/HSP90AA1	0.626155093051406
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1190	22/9376	1.43254392666157	MAOB/AOC1/ALDH7A1/ASPA	0.774401391807007
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	16/1190	109/9376	1.15654922519466	AKT3/PIK3R1/FOS/CTSK/MAPK10/MAP2K3/TLR4/NFKBIA/PIK3CB/JUN/RELA/TRAF6/TICAM1/AKT2/PIK3CA/MAPK11	0.626783909181136
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1190	65/9376	1.21215255332902	AKT3/TRPC4/PIK3R1/CACNA1C/CACNA1H/PIK3CB/AKT2/PIK3CA/CACNA1D/ESR2	0.654380014095492
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1190	37/9376	1.27767431296843	GLUL/ASPA/RIMKLB/GLUD1/CPS1/GLS	0.645222686458714
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1190	37/9376	1.27767431296843	MAOB/AOC3/AOX1/ADH1B/PNMT/LRTOMT	0.645222686458714
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1190	23/9376	1.37025940811107	GLUL/GLUD1/CPS1/GLS	0.67782534240145
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/1190	149/9376	1.11046190288196	MT-ND4L/CNR1/MT-ND3/MAPK10/GRIA1/GNG4/ADCY1/GNAI1/MGLL/GNAO1/ADCY2/CACNA1C/GNB5/ADCY3/PTGS2/DAGLB/GABRB3/ADCY9/MAPK11/CACNA1D/ADCY4	0.518201472836975
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	15/1190	104/9376	1.13639301874596	PLA2G2A/SGMS2/PLA2G5/PEMT/LPCAT1/PLPP1/LPIN1/GPCPD1/PLA1A/PISD/DGKA/PNPLA7/PLA2G4A/GDPD5/PLA2G6	0.533267785005543
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/1190	60/9376	1.1818487394958	IGF1R/GRIA1/GNAI1/GNAO1/CRH/PLA2G4A/PPP2R1B/IGF1/GUCY1B1	0.538758864657771
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/1190	38/9376	1.24405130473242	UGP2/UAP1/UGDH/GNPNAT1/PMM2/GNE	0.574737118208086
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	5/1190	31/9376	1.27080509623204	PRPS2/ALDOB/IDNK/RGN/RBKS	0.575799489898776
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	12/1190	83/9376	1.13913131517667	SFMBT2/AUTS2/ASXL1/CBX7/PHF1/YAF2/EZH2/RYBP/L3MBTL4/FOXK2/UBE2D1/L3MBTL1	0.48541055632412
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1190	17/9376	1.39041028175976	MTR/KYAT1/CTH	0.614262824544302
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	14/1190	99/9376	1.11420083184789	CFH/MASP1/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/C5AR1/PLG/HLA-DPA1/KRT18/FPR3/IL10	0.435518226588382
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	5/1190	32/9376	1.23109243697479	BCL2/MAPK10/BBC3/NGFR/BCL2L1	0.499249404424555
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1190	47/9376	1.17346683354193	ME3/ALDH7A1/ADH1B/ACSS1/ACYP1/ACACB/ACYP2	0.454538926716995
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	9/1190	63/9376	1.12557022809124	ALDH7A1/PRDM2/AASS/DOT1L/SETDB2/HYKK/KMT2C/EZH2/AADAT	0.381272432420717
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1190	48/9376	1.14901960784314	AKT3/PIK3R1/PIK3CB/AKT2/PIK3CA/SLC2A5/CACNA1D	0.394632650975535
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1190	41/9376	1.15302316048371	NBN/RAD51B/RBBP8/UIMC1/RAD51C/BARD1	0.374382192594249
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/1190	41/9376	1.15302316048371	THBS1/EGFR/MYC/VEGFA/DAPK2/DAPK3	0.374382192594249
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1190	26/9376	1.21215255332902	PLA2G2A/PLA2G5/PLA2G4A/PLA2G6	0.413002214478617
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	30/1190	227/9376	1.04127642246326	MT-ATP8/AKT3/MT-ND4L/MT-ND3/MAP3K5/PIK3R1/NOX4/FOS/MAPK10/COX7A1/FOXO3/PTEN/GSTM5/EGFR/ABL2/VEGFA/MAP3K14/PTPN11/NFKBIA/PTPN1/SLC26A6/GSTM2/PIK3CB/JUN/RELA/PRKD1/AS3MT/AKT2/PIK3CA/MAPK11	0.240022200135888
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1190	19/9376	1.24405130473242	IDS/HYAL1/HGSNAT	0.405987692611928
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1190	19/9376	1.24405130473242	AMT/ACSM1/BCKDHB	0.405987692611928
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	7/1190	50/9376	1.10305882352941	MAOB/AOC1/CKB/SAT1/ALDH7A1/AMD1/CKMT2	0.278577300616363
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1190	27/9376	1.16725801431684	ELOVL5/BAAT/ELOVL7/ELOVL4	0.33182529371099
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/1190	66/9376	1.07440794499618	CYP7B1/UGT2B7/CYP3A5/HSD17B6/STS/SULT2B1/HSD17B2/LRTOMT/HSD3B1	0.231280856162264
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	14/1190	107/9376	1.03089609675646	FOXO1/AKT3/CREB5/PRKAB2/ADCY2/CREB3L2/PYGM/CAMK2D/PPP3CB/PPARGC1A/ACACB/AKT2/PRKAG2/CREB3L1	0.1225468953121
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/1190	115/9376	1.0276945560833	MAOB/DUSP1/CYP4X1/KCND2/GNG4/HTR2A/GNAI1/GNAO1/HTR2B/CACNA1C/GNB5/PLA2G4A/PTGS2/GABRB3/CACNA1D	0.113929878712712
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	20/1190	156/9376	1.01012712777419	AKT3/PIK3R1/EGFR/MYC/CLDN5/CFLAR/CLDN4/NFKBIA/SOCS3/PPP2R1B/MX2/STAT3/PIK3CB/OAS2/FAS/RELA/TRAF6/TICAM1/AKT2/PIK3CA	0.0486302359694142
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1190	38/9376	1.03670942061035	ADA/IL7R/CD3E/CIITA/UNG	0.0864501283277839
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1190	30/9376	1.05053221288515	PLA2G2A/PLA2G5/PLA2G4A/PLA2G6	0.105691315844731
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	30/1190	238/9376	0.993150201256973	VWF/PIK3R1/FOS/MASP1/MAPK10/PLCG2/C7/ACE/EGFR/CSF3/TLR4/IL6R/C5AR1/RPS29/ACE2/CGAS/NFKBIA/ADAM17/MX2/RPS27/STAT3/PIK3CB/IL6ST/OAS2/JUN/RELA/NFKBIB/TRAF6/PIK3CA/MAPK11	-0.0408097525927691
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1190	63/9376	1.00050686941443	PLA2G2A/PLA2G5/PLA2G4A/HPGD/CYP2U1/PLA2G6/PTGS2/GGT5	0.0015390219281907
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/1190	55/9376	1.0027807486631	CERS6/SGMS2/CERS4/PLPP1/SPTLC2/B4GALT5/ACER2	0.00788560604733796
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1190	31/9376	1.01664407698563	UGDH/UGT2B7/ALDH7A1/RGN	0.0353894781579428
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/1190	31/9376	1.01664407698563	AOC3/ALDH7A1/DPYD/CSAD	0.0353894781579428
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	3/1190	23/9376	1.0276945560833	AQP1/GLUD1/GLS	0.050699783850434
NA	NA	hsa03272	Virion - Hepatitis viruses	6/1190	48/9376	0.984873949579832	EGFR/CLDN5/CLDN4/CHMP4B/HSPG2/SLC10A1	-0.0400566976554116
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	4/1190	32/9376	0.984873949579832	ACSS3/ACSS1/BCKDHB/ACACB	-0.0326781428350615
Organismal Systems	Digestive system	hsa04976	Bile secretion	11/1190	90/9376	0.962987861811391	ADCY1/UGT2B7/BAAT/ADCY2/SLC27A5/ABCB1/ADCY3/AQP1/ADCY9/SLC10A1/ADCY4	-0.134516122105968
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/1190	24/9376	0.984873949579832	XYLT1/NDST1/HS3ST2	-0.0282879948476648
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	10/1190	82/9376	0.960852633736421	GSTM5/UCK2/UGT2B7/CYP2A7/DPYD/GSTM2/CDA/UPP1/UPP2/CMPK1	-0.135747359301904
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1190	16/9376	0.984873949579832	MAOB/AOC3	-0.0230871784297816
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	9/1190	75/9376	0.945478991596639	GLUL/PRPS2/ALDOB/MTR/SDS/MAT2B/PSPH/CTH/CPS1	-0.180739442382309
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1190	51/9376	0.926940187839842	PLA2G2A/PLA2G5/LPCAT1/PLPP1/PLA2G4A/PLA2G6	-0.199463055632295
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/1190	51/9376	0.926940187839842	PLCG2/TJP2/ATP6V0A1/ADCY3/ADCY9/ARF1	-0.199463055632295
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	8/1190	68/9376	0.926940187839842	ALDH1A1/ALDH1A2/AOX1/UGT2B7/CYP3A5/CYP2A7/ADH1B/HSD17B6	-0.230530328468569
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/1190	93/9376	0.93192373723683	CST3/ADCY1/CST2/ADCY2/KCNMA1/ADCY3/ATP2B4/ADCY9/RYR3/GUCY1B1/ADCY4	-0.251545326963976
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1190	43/9376	0.916161813562634	APOB/APOA1/PLA2G2A/PLA2G5/PLPP1	-0.210081939795325
NA	NA	hsa04382	Cornified envelope formation	26/1190	217/9376	0.944026642915231	COL4A1/KAZN/COL4A2/ITGA6/COL4A4/PCSK6/LAMA3/COL4A3/CLDN5/ABHD5/S100A3/KRT5/TCHH/PPP2R3A/SPTLC2/CLDN4/CYP4F22/KRT8/S100A4/PPP2R1B/KRT18/S100A8/COL17A1/ELOVL4/KRT7/PPP2R5D	-0.31806101555636
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/1190	102/9376	0.926940187839842	PLA2G2A/ADCY1/PLA2G5/ADCY2/KCNMA1/CPB1/ADCY3/ATP2B4/RAP1B/ADCY9/SLC26A3/ADCY4	-0.282857917832348
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/1190	35/9376	0.900456182472989	ALDOB/PFKFB3/GMDS/PMM2	-0.22494423997028
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	28/1190	235/9376	0.938773466833542	MT-ATP8/MT-ND4L/CNR1/MT-ND3/MAP3K5/CREB5/ZNF516/COX7A1/NPR1/PPARG/ADCY1/MAP2K3/PRKAB2/RPS6KA2/MGLL/FGFR1/ADCY2/CREB3L2/ACSL1/SMARCA2/ADCY3/PPARGC1A/ADCY9/NDUFAF2/PRKAG2/CREB3L1/MAPK11/ADCY4	-0.362409851273786
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1190	44/9376	0.895339954163484	MAN2A1/ALG14/MGAT4C/ALG11/ALG13	-0.265303599638978
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/1190	53/9376	0.891961312827018	ESR1/AP2B1/ATP2B4/SLC8A1/ADCY9/DNM3	-0.300720226401065
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1190	27/9376	0.875443510737628	ACSM3/ACSM1/OXCT1	-0.24710919714019
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1190	18/9376	0.875443510737628	ACSL1/ACACB	-0.201666768676569
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1190	18/9376	0.875443510737628	MTR/TCN2	-0.201666768676569
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1190	36/9376	0.875443510737628	UGP2/UGDH/UGT2B7/CRPPA	-0.285474564933785
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1190	36/9376	0.875443510737628	UGP2/GANC/PYGM/AGL	-0.285474564933785
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	16/1190	138/9376	0.913506272074047	PGR/AR/IGF1R/ADCY1/RPS6KA2/ADCY2/CAMK2D/ANAPC7/PPP2R1B/PPP3CB/ADCY3/IGF1/ADCY9/PPP2R5D/MAPK11/ADCY4	-0.390263943653707
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	24/1190	205/9376	0.922418528386965	MT-ATP8/INSR/AKT3/PDK4/MT-ND4L/MT-ND3/PIK3R1/MAPK10/COX7A1/ACE/PTEN/SMAD3/TGFBR2/REN/PLN/CAMK2D/TGFBR1/PIK3CB/RELA/AGT/IRS1/AKT2/PIK3CA/MAPK11	-0.428203138240657
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1190	28/9376	0.844177671068427	ELOVL5/ELOVL7/ELOVL4	-0.314827458603174
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	38/1190	323/9376	0.926940187839842	TIMP3/THBS1/IRS2/ZEB1/HOXD10/TNC/PIK3R1/BCL2/PLCG2/MCL1/PTEN/FOXP1/PIM1/PDGFRA/EGFR/MYC/PDGFRB/TNXB/TPM1/SLC7A1/PRKCE/VEGFA/ITGA5/ZFPM2/NOTCH3/ABCB1/CD44/PTGS2/STAT3/PIK3CB/EZH2/HDAC4/TP63/IRS1/RECK/PIK3CA/NOTCH4/GLS	-0.509456140299143
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/1190	73/9376	0.863451133878209	MAOB/AOX1/GSTM5/UGT2B7/CYP3A5/CYP2A7/ADH1B/GSTM2	-0.446540923799508
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1190	30/9376	0.787899159663866	PIGU/PIGA/GPLD1	-0.443622307969126
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/1190	67/9376	0.823178226514486	GRIA1/ADCY1/RPS6KA2/CACNA1C/CAMK2D/PPP3CB/RAP1B	-0.553789703937883
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/1190	76/9376	0.82936753648828	ADCY1/MYLK/GNAI1/ADCY2/CAMK2D/ADCY3/ADCY9/ADCY4	-0.569442964473819
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	2/1190	21/9376	0.750380152060824	DPYD/CSAD	-0.436606417044894
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	17/1190	154/9376	0.869758812615955	UGP2/GPHN/UGDH/UGT2B7/GCLC/HSD17B6/CTPS1/MTHFD2/KMO/RGN/PMM2/MAT2B/ALAD/CMPK1/GCH1/VKORC1L1/CTPS2	-0.62132581356597
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/1190	31/9376	0.762483057739225	GLUL/AMT/ACSS1	-0.50502053358289
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/1190	12/9376	0.656582633053221	VKORC1L1	-0.453842772163402
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1190	12/9376	0.656582633053221	NGFR	-0.453842772163402
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1190	23/9376	0.685129704055535	LARGE1/CRPPA	-0.576425774700582
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/1190	43/9376	0.732929450850107	ALDH7A1/ADH1B/ACSL1/CYP2U1	-0.669226058098581
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	44/1190	388/9376	0.893493892402322	MT-ATP8/INSR/DKK1/IRS2/AKT3/MT-ND4L/MT-ND3/MAP3K5/PIK3R1/NOX4/MAPK10/COX7A1/ERN1/CACNA1C/EIF2AK3/FZD8/WNT9A/ADAM17/PPP3CB/PTGS2/SLC39A10/LPL/PIK3CB/RB1CC1/FAS/RELA/TUBA1A/PSEN1/IRS1/RYR3/CHRM5/LRP5/AXIN1/APBB1/SLC39A11/MCU/CAPN2/MME/AKT2/PIK3CA/WNT2B/CACNA1D/ATF6/WNT5A	-0.816924823188443
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/1190	54/9376	0.729536258948024	REV3L/HES1/MLH1/FANCL/RAD51C	-0.759931820884221
NA	NA	hsa04082	Neuroactive ligand signaling	21/1190	199/9376	0.831451374519657	ADRA2C/P2RY14/GRIA1/GNG4/ADCY1/HTR2A/GNAI1/GNAO1/HTR2B/ADCY2/GRM7/GNB5/GNAL/ADCY3/GABRB3/ADCY9/CHRM5/GRIK2/P2RX1/P2RY1/ADCY4	-0.916272466155334
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	6/1190	65/9376	0.727291531997414	MGLL/PLPP1/LPIN1/ALDH7A1/DGKA/LPL	-0.841163437984783
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/1190	14/9376	0.562785114045618	B3GNT2	-0.624162810083247
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/1190	46/9376	0.685129704055535	HEPH/UGT2B7/CP/ALAD	-0.816193318141785
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1190	56/9376	0.703481392557023	MAN2A1/ALG14/MGAT4C/ALG11/ALG13	-0.848518387400131
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/1190	26/9376	0.606076276664512	HES1/NR5A2	-0.766860297084916
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/1190	48/9376	0.656582633053221	AOX1/ALDH7A1/BCKDHB/OXCT1	-0.909435394917305
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	13/1190	133/9376	0.770126998167688	PIK3R1/NFATC1/PLCG2/HLA-G/NFATC2/PTPN11/FYN/TNFSF10/PPP3CB/PIK3CB/PTK2B/FAS/PIK3CA	-1.01795964095919
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/1190	87/9376	0.724504974403555	CACNB2/COX7A1/TPM1/CACNA1C/TNNT2/SLC8A1/CACNA1D/CACNB1	-0.984265256263212
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	5/1190	59/9376	0.667711152257513	GPX3/GSTM5/GCLC/GSTM2/GGT5	-0.976173407411825
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	11/1190	116/9376	0.747145754853666	PRPS2/ME3/ALDOB/AMT/ACSS1/SDS/IDNK/RGN/GLUD1/PSPH/CPS1	-1.04476111298609
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/1190	16/9376	0.492436974789916	B3GALT5	-0.774703098421566
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1190	28/9376	0.562785114045618	B3GNT2/B3GALT5	-0.883360249794115
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1190	28/9376	0.562785114045618	GPHN/GCH1	-0.883360249794115
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	14/1190	144/9376	0.766013071895425	AKT3/MAP3K5/PIK3R1/MAPK10/GRIA1/RORA/KCND3/ERN1/RELN/PIK3CB/RB1CC1/MCU/AKT2/PIK3CA	-1.07881802160244
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1190	70/9376	0.675342136854742	GSTM5/UGT2B7/CYP3A5/CYP2A7/GSTM2/PTGS2	-1.03948127514372
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	6/1190	72/9376	0.656582633053221	MAPK10/NFKBIA/RELA/NFKBIB/TRAF6/MAPK11	-1.11526198794348
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/1190	30/9376	0.525266106442577	MTR/RELA	-0.992935931782982
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	39/1190	370/9376	0.83048830342948	ADRA2C/CNR1/LPAR1/F2R/PRLR/P2RY14/PTGER3/GRIA1/AVPR1A/CALCRL/OXTR/EDNRA/GRID1/GHR/ADM/HTR2A/S1PR3/CSH2/RXFP1/HTR2B/CRH/C5AR1/GRM7/KNG1/F2RL2/PLG/OXT/NPY1R/GLP2R/AGT/GABRB3/EDN1/LYNX1/CHRM5/GRIK2/FPR3/P2RX1/GZMA/P2RY1	-1.26840460484011
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	15/1190	158/9376	0.748005531326455	GADD45A/GADD45B/MYC/WEE1/NDC80/SMAD3/STAG1/GADD45G/ANAPC7/PPP2R1B/CDC14A/PPP2R5D/RAD21/CCND3/MCM6	-1.2179359459824
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/1190	83/9376	0.664493267186393	ABCD2/BAAT/ACSL1/FAR2/SLC25A17/PEX19/PEX5	-1.17053813240203
NA	NA	hsa04981	Folate transport and metabolism	2/1190	31/9376	0.508322038492816	BHMT2/MTR	-1.04543054532372
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	27/1190	268/9376	0.793779004138969	MT-ATP8/MT-ND4L/MAOB/SNCAIP/DUSP1/MT-ND3/MAP3K5/MAPK10/COX7A1/GNAI1/ERN1/UBE2G2/LRRK2/EIF2AK3/CAMK2D/GNAL/SEPTIN5/SLC39A10/PRKN/TUBA1A/BCL2L1/RYR3/SLC39A11/MCU/UBE2G1/UBC/ATF6	-1.30590629259989
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1190	32/9376	0.492436974789916	UGP2/GANC	-1.09653323735429
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	51/1190	480/9376	0.837142857142857	GPX3/MT-ATP8/DKK1/MT-ND4L/SNCAIP/MT-ND3/MAP3K5/NOX4/BCL2/MAPK10/COX7A1/GRIA1/MAP2K3/ERN1/CACNA1C/UBE2G2/LRRK2/EIF2AK3/FZD8/DNAH11/CAMK2D/SEPTIN5/WNT9A/HIP1/ACTR1B/MAP1LC3A/PPP3CB/WDR41/PTGS2/PRKN/RB1CC1/FAS/RELA/TUBA1A/PSEN1/BCL2L1/RYR3/CHRM5/LRP5/AXIN1/DNAH7/MCU/CAPN2/MAP1LC3C/UBE2G1/UBC/MAPK11/WNT2B/CACNA1D/ATF6/WNT5A	-1.39653971786228
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1190	20/9376	0.393949579831933	SOAT1	-1.03443188030512
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/1190	33/9376	0.477514642220525	AADAT/BCKDHB	-1.14633398625778
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/1190	33/9376	0.477514642220525	STX18/STX8	-1.14633398625778
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/1190	57/9376	0.552911690992186	ELOVL5/ACSL1/ELOVL7/ELOVL4	-1.29083084428681
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6/1190	79/9376	0.598404425061164	GSTM5/UGT2B7/CYP3A5/CYP2A7/ADH1B/GSTM2	-1.36664053442593
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1190	23/9376	0.342564852027768	MLH1	-1.2035513332516
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	26/1190	275/9376	0.744922841864018	MT-ATP8/MT-ND4L/MT-ND3/PIK3R1/CREB5/MAPK10/HSPA6/COX7A1/C7/HSPA1B/CREB3L2/CACNA1C/HSPA1A/EIF2AK3/FYN/CAV1/PPP3CB/PIK3CB/EGR1/TUBA1A/RYR3/MCU/PIK3CA/CREB3L1/MAPK11/CACNA1D	-1.6368791176363
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	2/1190	38/9376	0.41468376824414	AOX1/NNMT	-1.37841084131312
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/1190	250/9376	0.724867226890756	MITF/CTSK/OSBPL5/CTSH/NCOA7/ATP6V0A1/LITAF/DEPTOR/ARSG/IDS/ABCA5/SLC11A1/VPS13A/AP2B1/OSBPL3/AP1M1/TPCN1/HYAL1/OSBP/ACP5/SORT1/TFE3/HGSNAT	-1.68110696069535
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/1190	86/9376	0.549697088137581	PDE1A/CACNA1C/PDE1C/ASIC2/P2RY1/ADCY4	-1.59944522855576
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	8/1190	108/9376	0.583629007158419	NUP153/AHCTF1/NUP98/RANGAP1/DDX19A/NUP43/KPNA5/KPNA1	-1.65929108562342
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	2/1190	41/9376	0.384341053494569	GRIA1/GABRB3	-1.50625399158131
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/1190	67/9376	0.470387558008278	ALDOB/ALDH7A1/ADH1B/ACSS1	-1.65869797407299
Human Diseases	Substance dependence	hsa05034	Alcoholism	16/1190	191/9376	0.660020238461877	MAOB/FOSB/CREB5/GNG4/GNAI1/GNAO1/CRH/CREB3L2/GNB5/CAMKK2/HDAC7/CAMKK1/HDAC4/HDAC11/CREB3L1/NTRK2	-1.80989515305891
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/1190	28/9376	0.281392557022809	ATP6V0A1	-1.45189304098506
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	11/1190	143/9376	0.606076276664512	C7/HLA-DRB1/HLA-DQB1/HLA-DPB1/HLA-DRB5/HLA-DRA/HLA-DQA1/ACTN4/HLA-DPA1/ELANE/IL10	-1.80980584246589
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/1190	29/9376	0.271689365401333	SLC24A1	-1.49762395383888
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/1190	103/9376	0.535465448315248	PPP2R3A/PPP2R1B/SMG1/PABPC4/PPP2R5D/CPSF6/DDX19A	-1.8073811694521
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	16/1190	195/9376	0.646481361775479	AKT3/VWF/PIK3R1/PLCG2/TLR4/C5AR1/ELANE/HDAC7/PIK3CB/RELA/HDAC4/HDAC11/FPR3/AKT2/PIK3CA/MAPK11	-1.9019884545511
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	5/1190	83/9376	0.47463804799028	SAMHD1/CGAS/NFKBIA/RELA/NFKBIB	-1.83291760789249
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/1190	31/9376	0.254161019246408	IMMP2L	-1.58584055706456
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	8/1190	117/9376	0.538734468146233	CECR2/SMARCA2/INO80D/MORF4L2/GATAD2B/GATAD2A/BICRAL/EP400	-1.91419043006232
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/1190	32/9376	0.246218487394958	GABARAPL1	-1.62846078461391
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/1190	34/9376	0.23173504695996	POLR1E	-1.71101492412624
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/1190	36/9376	0.218860877684407	MCM6	-1.79031500017695
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/1190	79/9376	0.398936283374109	ATP6V0A1/UNC13B/AP2B1/DNM3	-2.04543598130719
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	25/1190	308/9376	0.639528538688203	GPX3/MT-ATP8/MT-ND4L/TGM2/MT-ND3/MAP3K5/CREB5/MAPK10/COX7A1/GRIA1/PPARG/TAF4B/ERN1/CREB3L2/DNAH11/HIP1/ACTR1B/AP2B1/PPARGC1A/BBC3/RB1CC1/TUBA1A/DNAH7/CREB3L1/SIN3A	-2.45252666761757
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	31/1190	368/9376	0.6637194008038	GPX3/MT-ATP8/MT-ND4L/MT-ND3/MAP3K5/BCL2/COX7A1/GRIA1/ANG/MAP2K3/ERN1/EIF2AK3/NUP153/DNAH11/ACTR1B/MAP1LC3A/PPP3CB/WDR41/PRKN/RB1CC1/NRG2/TUBA1A/NUP98/BCL2L1/NRG3/DNAH7/MCU/MAP1LC3C/NUP43/MAPK11/ATF6	-2.5091971287761
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/1190	44/9376	0.179067990832697	TAF4B	-2.08098721293464
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/1190	44/9376	0.179067990832697	UNG	-2.08098721293464
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/1190	46/9376	0.171282426013884	PSME4	-2.14816626155627
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	3/1190	78/9376	0.303038138332256	BTG2/TOB2/PABPC4	-2.35659413752375
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	10/1190	183/9376	0.430545988887358	GNL2/RIOK1/NOP58/RMRP/WDR43/MDN1/FCF1/REXO2/HEATR1/RCL1	-2.96605240454831
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/1190	138/9376	0.342564852027768	MT-ATP8/MT-ND4L/MT-ND3/COX7A1/ATP6V0A1/LHPP	-2.96637964042727
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/1190	243/9376	0.259390669848186	HSPA6/HSPA1B/HSPA1A/RBM25/HNRNPU/DDX5/SNIP1/PRPF18	-4.45973276371376
Genetic Information Processing	Translation	hsa03010	Ribosome	2/1190	222/9376	0.0709819062760239	RPS29/RPS27	-5.34094928808338
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	9/1190	449/9376	0.1579307892422	PDE1A/RGS2/ANO2/CAMK2D/GNAL/ADCY3/PDE2A/SLC8A1/PDE1C	-6.97174413579048