category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04518	Integrin signaling	28/306	154/9376	5.57100415923945	EGFR/FBN1/FN1/LAMA3/VEGFA/LAMB3/ITGA5/FLT1/FLNB/LAMB1/THBS1/ACTN1/PDGFD/PTK2/ITGB6/PIK3CB/ITGA6/MET/LAMB4/AKT3/IGF1R/CDH1/ACTN4/ITGA2/NPNT/FERMT2/PIK3R1/PDGFA	10.5051468045723
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	30/306	203/9376	4.52815609002222	EGFR/FN1/LAMA3/VEGFA/LAMB3/ITGA5/FLT1/FLNB/LAMB1/THBS1/ACTN1/PDGFD/PTK2/ITGB6/DIAPH1/PIK3CB/ITGA6/MET/LAMB4/CAPN2/AKT3/PIP5K1B/PPP1R12B/IGF1R/ACTN4/ITGA2/PIK3R1/DOCK1/VAV2/PDGFA	9.3343229101702
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	30/306	232/9376	3.96213657876944	EGFR/FN1/EZR/ITGA5/ACTN1/PDGFD/PTK2/ITGB6/DIAPH3/RGCC/DIAPH1/PIK3CB/ITGA6/TIAM1/RRAS2/AKT3/PIP5K1B/PPP1R12B/BDKRB2/ACTN4/KNG1/ITGA2/C7/BAIAP2/PIK3R1/DOCK1/VAV2/PDGFA/MYH9/SSH2	8.39119224128675
NA	NA	hsa04519	Cadherin signaling	37/306	404/9376	2.80618650100304	EGFR/KRT6A/TEAD1/KRT7/KRT8/TCF7L2/KRT19/LIMA1/DSP/PKP2/ACTN1/PTK2/JUP/DSG2/YAP1/WNT7A/MET/RRAS2/PCDH7/STK3/WWC1/KRT17/PKP3/DSC3/IGF1R/CDH1/ACTN4/AFDN/KRT14/TMC1/VAV2/YWHAZ/YWHAQ/AMOTL1/FAT1/WNT6/DSC2	6.81634165089067
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	25/306	204/9376	3.75496603870306	TIMP3/EGFR/FN1/EZR/VEGFA/ITGA5/THBS1/PLCG2/PTK2/PIK3CB/SDC4/WNT7A/TIAM1/MET/RRAS2/AKT3/CTTN/PPP1R12B/GAB1/IGF1R/ITGA2/PIK3R1/VAV2/MDM2/WNT6	7.30704897419472
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	26/306	233/9376	3.41911414064911	FBN1/SYNE2/FN1/ITGA5/THBS1/DSP/FBN2/PKP2/ITGB6/DIAPH3/TPM1/DIAPH1/ITGA6/JUP/SDC4/DSG2/PDLIM1/ACTG2/ITGA2/TMEM43/CSRP1/TMOD3/PLEC/INF2/MYH9/DSC2	6.86803767160846
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	16/306	93/9376	5.27148780659217	EGFR/TCF7L2/INSR/ACTN1/MET/PTPRF/SMURF1/IGF1R/CDH1/TGFBR1/ACTN4/AFDN/BAIAP2/PARD3/SMAD3/NECTIN4	7.60359852776776
NA	NA	hsa04517	IgSF CAM signaling	27/306	299/9376	2.76686995868582	EZR/TRIO/RASA1/ITGA5/IL1RAP/GRIP1/FOXO1/PLCG2/ACTN1/PTK2/PIK3CB/TJP2/RAPGEF2/PTPRF/AKT3/CDH1/ACTN4/F11R/AFDN/BAIAP2/PIK3R1/VAV2/PARD3/TUBB3/NECTIN4/TUBA1C/MYH9	5.70310964306863
NA	NA	hsa04382	Cornified envelope formation	22/306	217/9376	3.1064124574561	KRT6A/LAMA3/COL17A1/LAMB3/KRT7/CLDN4/KRT8/KRT19/PCSK6/DSP/PKP2/ITGA6/JUP/DSG2/KRT17/PKP3/PRSS8/CLDN3/KRT14/PPP2R3A/PLEC/CLDN7	5.76622998134611
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/306	110/9376	4.17825311942959	SERPINE1/EGFR/TF/VEGFA/FLT1/INSR/PLCG2/PFKP/PIK3CB/EGLN3/ALDOB/AKT3/IGF1R/HK2/PIK3R1	6.15859130468782
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	28/306	333/9376	2.5763803018705	EGFR/FN1/LAMA3/HLA-G/VEGFA/LAMB3/ITGA5/TCF7L2/LAMB1/THBS1/PTGS2/FOXO1/PTK2/ITGB6/PIK3CB/ITGA6/CREB5/WNT7A/LAMB4/AKT3/CREB3L2/ITGA2/LLGL2/PIK3R1/PARD3/PPP2R3A/MDM2/WNT6	5.37984246464175
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	29/306	362/9376	2.45462752320081	EGFR/FN1/LAMA3/VEGFA/LAMB3/ITGA5/FLT1/LAMB1/THBS1/INSR/PDGFD/PTK2/ITGB6/PIK3CB/ITGA6/CREB5/MET/LAMB4/AKT3/CREB3L2/IGF1R/ITGA2/EREG/PIK3R1/YWHAZ/YWHAQ/PPP2R3A/MDM2/PDGFA	5.18429871135358
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/306	78/9376	4.71392659627954	FN1/ITGA5/PTK2/PIK3CB/ARHGAP10/MET/CTTN/CLTB/GAB1/CDH1/PIK3R1/DOCK1	6.04962638587596
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/306	93/9376	4.28308384285614	FN1/LAMA3/LAMB3/LAMB1/PTGS2/PTK2/PIK3CB/ITGA6/LAMB4/AKT3/ITGA2/PIK3R1/BIRC7	5.84415843012671
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	15/306	122/9376	3.76727740276438	IRS2/INSR/FOXO1/PFKP/PIK3CB/CREB5/TBC1D1/AKT3/CREB3L2/IGF1R/PRKAG2/PIK3R1/ULK1/PPARG/PPP2R3A	5.65080827378879
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	12/306	80/9376	4.59607843137255	EGFR/VEGFA/PLCG2/PDGFD/PIK3CB/MET/AKT3/GAB1/IGF1R/NRG2/PIK3R1/PDGFA	5.93292419130113
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	22/306	238/9376	2.83231724062174	EGFR/VEGFA/RASA1/FLT1/RASAL2/INSR/PLCG2/PDGFD/RASGRF2/PIK3CB/PLA2G4A/TIAM1/MET/RRAS2/KSR1/AKT3/GAB1/IGF1R/AFDN/PIK3R1/PLAAT3/PDGFA	5.25903762063538
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	18/306	170/9376	3.24429065743945	EZR/CLDN4/ACTN1/TIAM1/TJP2/RAPGEF2/CTTN/ACTN4/F11R/AFDN/PRKAG2/CLDN3/LLGL2/PARD3/CLDN7/TUBA1C/AMOTL1/MYH9	5.42388889754982
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	15/306	133/9376	3.45569806870116	EGFR/FBXO32/IRS2/INSR/FOXO1/PIK3CB/AKT3/PLK2/IGF1R/TGFBR1/PRKAG2/HOMER1/PIK3R1/SMAD3/MDM2	5.23886274746003
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/306	89/9376	4.13130645516634	FN1/LAMA3/LAMB3/ITGA5/LAMB1/THBS1/ITGB6/ITGA6/SDC4/LAMB4/ITGA2/NPNT	5.45161981949299
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	12/306	90/9376	4.08540305010893	IRS2/INSR/FOXO1/PIK3CB/CREB5/AKT3/CREB3L2/IGF1R/PRKAG2/PIK3R1/ULK1/PPARG	5.40208641920142
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	21/306	253/9376	2.54328450747888	EGFR/ITGA5/FOXO1/PLCG2/ACTN1/PTK2/DIAPH1/PIK3CB/CAST/CAPN2/AKT3/FNBP1L/CTTN/ACTN4/CYTH3/HK2/PIK3R1/CUL1/DOCK1/MDM2/IL1R1	4.57067274634957
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/306	116/9376	3.43385170160018	EZR/CLDN4/PLCG2/ACTN1/PTK2/PIK3CB/ACTN4/F11R/AFDN/CLDN3/PIK3R1/VAV2/CLDN7	4.84462673661131
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/306	86/9376	3.91913664690682	ITGA5/TCF7L2/CACNA2D3/DSP/PKP2/ITGB6/ITGA6/JUP/DSG2/ITGA2/DSC2	4.99503460876265
Human Diseases	Cancer: specific types	hsa05218	Melanoma	10/306	73/9376	4.19733190079685	EGFR/PDGFD/PIK3CB/MET/AKT3/IGF1R/CDH1/PIK3R1/MDM2/PDGFA	5.03709739528205
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	12/306	103/9376	3.56976965543499	FN1/LAMA3/LAMB3/LAMB1/ACTN1/PTK2/PIK3CB/LAMB4/ACTN4/PIK3R1/CXCL3/IL1R1	4.81665329716058
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	12/306	106/9376	3.46873843877174	EGFR/TCF7L2/FOXO1/PDGFD/PIK3CB/CREB5/AKT3/CREB3L2/IGF1R/PIK3R1/MDM2/PDGFA	4.69494871484161
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	15/306	157/9376	2.9274384913201	SERPINE1/TEAD1/TCF7L2/YAP1/WNT7A/STK3/WWC1/CDH1/TGFBR1/LLGL2/PARD3/YWHAZ/YWHAQ/SMAD3/WNT6	4.47333223320004
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	18/306	212/9376	2.6015538290788	EGFR/VEGFA/FLT1/THBS1/INSR/PDGFD/PIK3CB/TIAM1/RAPGEF2/MET/AKT3/IGF1R/CDH1/AFDN/PIK3R1/VAV2/PARD3/PDGFA	4.33221137390715
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	12/306	109/9376	3.37326857348444	IRS2/INSR/FOXO1/PIK3CB/CREB5/PTPRF/AKT3/CREB3L2/PRKAG2/PIK3R1/SLC27A6/GFPT1	4.57755176049249
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	22/306	300/9376	2.24697167755991	EGFR/VEGFA/RASA1/FLT1/CACNA2D3/IL1RAP/INSR/PDGFD/RASGRF2/PLA2G4A/RAPGEF2/MET/RRAS2/PTPRR/STK3/AKT3/IGF1R/TGFBR1/EREG/MAP3K9/PDGFA/IL1R1	4.03192719252731
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	14/306	149/9376	2.87897530376804	EGFR/INSR/PLCG2/PDGFD/PIK3CB/PLA2G4A/RRAS2/AKT3/PIP5K1B/GAB1/CYTH3/PIK3R1/DGKI/PDGFA	4.24645624788482
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	11/306	101/9376	3.33708664984145	SERPINE1/FN1/VEGFA/FOXO1/PLCG2/DIAPH1/PIK3CB/AKT3/TGFBR1/PIK3R1/SMAD3	4.33731785702683
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	8/306	59/9376	4.1546471696023	IRS2/PTGS2/INSR/MGLL/PIK3CB/AKT3/PIK3R1/PLAAT3	4.46458873145394
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/306	60/9376	4.08540305010893	VEGFA/PTGS2/PLCG2/PTK2/PIK3CB/PLA2G4A/AKT3/PIK3R1	4.40367741329482
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/306	62/9376	3.95361585494413	IRS2/INSR/FOXO1/PIK3CB/AKT3/IGF1R/PRKAG2/PIK3R1	4.28572644132001
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/306	150/9376	2.65551198257081	EGFR/TCF7L2/PIK3CB/JUP/WNT7A/MET/AKT3/GAB1/CDH1/TGFBR1/PIK3R1/SMAD3/WNT6	3.75417005135018
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/306	98/9376	3.1265839669201	PLCG2/PIK3CB/PLA2G4A/ASAP2/AKT3/PIP5K1B/ASAP3/PIK3R1/DOCK1/VAV2	3.88696917836779
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/306	38/9376	4.83797729618163	UAP1/PGM1/UGP2/HEXB/HK2/GFPT1	4.35421603412262
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	14/306	170/9376	2.52333717800846	EGFR/TCF7L2/PLCG2/PIK3CB/WNT7A/MET/AKT3/GAB1/IGF1R/TGFBR1/PIK3R1/MGST1/SMAD3/WNT6	3.68152475243634
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	10/306	99/9376	3.09500231068859	EGFR/PDGFD/PIK3CB/PLA2G4A/AKT3/PIP5K1B/SLC44A2/PIK3R1/DGKI/PDGFA	3.84893904428316
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/306	86/9376	3.20656634746922	EGFR/PLCG2/PTK2/PIK3CB/AKT3/GAB1/EREG/NRG2/PIK3R1	3.7757311853896
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/306	41/9376	4.48397895743663	EGFR/VEGFA/THBS1/CDH1/DAPK1/MDM2	4.10632196740477
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/306	110/9376	2.78550207961973	FBN1/TF/INHBA/THBS1/LTBP1/SMURF1/TGFBR1/CUL1/ID4/SMAD3	3.45981807264664
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/306	76/9376	3.22531819745442	EGFR/PLCG2/PIK3CB/AKT3/IGF1R/PIK3R1/MDM2/PDGFA	3.57766892799324
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/306	112/9376	2.73576097105509	LAMA3/LAMB3/LAMB1/ITGA6/LAMB4/HLA-DRB5/AKT3/HLA-DRB1/BIRC7/HLA-DQA1	3.39423857618719
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	12/306	157/9376	2.34195079305608	SERPINE1/HLA-G/FOXO1/PIK3CB/RRAS2/CAPN2/AKT3/TGFBR1/PIK3R1/RAD50/SMAD3/MDM2	3.11449198767151
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	11/306	138/9376	2.44236051908686	IRS2/INSR/FOXO1/PIK3CB/PTPRF/AKT3/PRKAG2/HK2/PIK3R1/TRIP10/PRKAR2B	3.13521333990303
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/306	36/9376	4.2556281771968	GALNT15/GALNT2/GCNT1/GALNT7/GALNT6	3.59463930554294
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/306	160/9376	2.29803921568627	HLA-G/CLDN4/ITGA6/SDC4/PTPRF/HLA-DRB5/CDH1/F11R/HLA-DRB1/CLDN3/HLA-DQA1/CLDN7	3.04172032338146
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	8/306	85/9376	2.88381391772395	ADK/GDA/UPP1/UCK2/CTPS1/CDA/NT5E/AK4	3.20449015673257
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/306	37/9376	4.14061119943473	UAP1/PGM1/UGP2/HK2/GFPT1	3.51566558194903
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/306	184/9376	2.16481955100881	RASA1/PLCG2/SEMA5A/PTK2/PIK3CB/MET/SEMA6D/SEMA3C/PIK3R1/PARD3/SEMA7A/RHOD/SSH2	2.93092876389286
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	8/306	87/9376	2.81751934490271	EGFR/TCF7L2/PIK3CB/AKT3/TGFBR1/EREG/PIK3R1/SMAD3	3.12821716533512
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/306	70/9376	3.0640522875817	VEGFA/PIK3CB/EGLN3/MET/AKT3/GAB1/PIK3R1	3.18369091900177
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/306	71/9376	3.02089662155942	EGFR/PFKP/PIK3CB/MET/AKT3/HK2/PIK3R1	3.13948051080278
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/306	76/9376	2.82215342277262	APOA2/APOC3/APOA1/ACSL3/PLIN2/SLC27A6/PPARG	2.92949641545528
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/306	59/9376	3.11598537720173	EGFR/TCF7L2/PIK3CB/AKT3/CDH1/PIK3R1	2.99463108331291
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/306	77/9376	2.78550207961973	EGFR/VEGFA/PIK3CB/AKT3/TGFBR1/PIK3R1/SMAD3	2.88955062024003
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	7/306	77/9376	2.78550207961973	PIK3CB/CTBP2/AKT3/TGFBR1/PIK3R1/SMAD3/MDM2	2.88955062024003
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/306	29/9376	4.22627901735407	TEAD1/YAP1/STK3/WWC1	3.19600543477746
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	13/306	200/9376	1.9916339869281	EZR/CLDN4/BAIAP2L1/CTTN/CYTH3/CLDN3/BAIAP2/MYO5B/TUBB3/CLDN7/TUBA1C/MYH9/IL1R1	2.60364882166132
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	11/306	158/9376	2.13320095970878	INSR/PIK3CB/WNT7A/GRB10/AKT3/IGF1R/CLIP1/LPIN1/PIK3R1/ULK1/WNT6	2.6385166139637
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	10/306	138/9376	2.22032774462442	FN1/ITGA5/PTK2/PIK3CB/AKT3/PIP5K1B/BAIAP2/PIK3R1/DOCK1/VAV2	2.65258773612469
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/306	99/9376	2.47600184855087	IL1RAP/PLCG2/PIK3CB/PLA2G4A/BDKRB2/KNG1/PIK3R1/IL1R1	2.71171115914154
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	10/306	139/9376	2.20435416372784	EGFR/KRT19/PIK3CB/CREB5/AKT3/KRT17/CREB3L2/KRT14/PIK3R1/FKBP5	2.62747658616902
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/306	119/9376	2.3173504695996	PTGS2/PIK3CB/CREB5/AKT3/CREB3L2/CCL20/PIK3R1/CXCL3/TNFAIP3	2.65633220319061
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	8/306	100/9376	2.45124183006536	MME/ITGA5/ITGA6/HLA-DRB5/ITGA2/HLA-DRB1/HLA-DQA1/IL1R1	2.6797984141066
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	15/306	250/9376	1.83843137254902	EGFR/HLA-G/ASAP2/PIP5K1B/SMURF1/CLTB/ASAP3/IGF1R/TGFBR1/CYTH3/RAB11FIP3/PARD3/SMAD3/MDM2/CHMP4C	2.46797070604482
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	10/306	142/9376	2.15778330111387	VEGFA/PTK2/PIK3CB/SDC4/AKT3/PIK3R1/MGST1/PDGFA/TXN/IL1R1	2.55340218907508
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/306	47/9376	3.25963009317202	IRS2/INSR/PIK3CB/HK2/PIK3R1	2.85240664993259
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/306	122/9376	2.26036644165863	FOXO1/PLCG2/PFKP/THRB/PIK3CB/AKT3/DIO2/PIK3R1/MDM2	2.57368094337621
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	18/306	323/9376	1.70752139865234	TIMP3/EGFR/EZR/VEGFA/ITGA5/IRS2/THBS1/PTGS2/PLCG2/SLC7A1/TPM1/PIK3CB/MET/PIK3R1/EZH2/MDM2/KIF23/PDGFA	2.37677071817343
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/306	144/9376	2.1278140885984	INHBA/PIK3CB/WNT7A/AKT3/IGF1R/PIK3R1/ID4/LIFR/SMAD3/WNT6	2.5050336928227
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/306	32/9376	3.83006535947712	PFKP/PGM1/UGP2/HK2	2.94542350146066
NA	NA	hsa03272	Virion - Hepatitis viruses	5/306	48/9376	3.1917211328976	EGFR/CLDN4/EPCAM/CLDN3/CLDN7	2.79611064613674
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/306	105/9376	2.33451602863368	PTGS2/PLCG2/PIK3CB/RRAS2/KSR1/AKT3/PIK3R1/MDM2	2.52579361640778
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/306	68/9376	2.70357554786621	TCF7L2/ZBTB16/PIK3CB/JUP/AKT3/PIK3R1	2.58958621647326
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/306	34/9376	3.60476739715494	PRKAG2/BHLHE40/CUL1/NPAS2	2.7946741787593
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/306	69/9376	2.6643932935493	PLCG2/PIK3CB/PLA2G4A/AKT3/PIK3R1/VAV2	2.54869785542357
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	8/306	109/9376	2.24884571565629	IL1RAP/GATA3/HLA-DRB5/TGFBR1/HLA-DRB1/HLA-DQA1/SMAD3/IL1R1	2.40876905722169
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/306	52/9376	2.94620412267471	APOA2/APOC3/APOB/APOA1/APOC2	2.58482791663519
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/306	36/9376	3.40450254175744	GBE1/PGM1/UGP2/HK2	2.654885286784
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	11/306	178/9376	1.8935154586179	TCF7L2/SFRP1/TLE1/CTBP2/WNT7A/FOSL1/CUL1/ROR1/SMAD3/WNT6/LGR4	2.21058936859841
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/306	73/9376	2.51839914047811	EGFR/PLCG2/PIK3CB/MET/AKT3/PIK3R1	2.39209584516222
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	13/306	224/9376	1.77824463118581	HLA-G/PIK3CB/CREB5/HLA-DRB5/AKT3/CREB3L2/TGFBR1/HLA-DRB1/FOSL1/PIK3R1/HLA-DQA1/SMAD3/IL1R1	2.16533374801737
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	8/306	115/9376	2.13151463483944	EGFR/AKAP13/CREB5/GATA3/CREB3L2/OXSR1/SLC34A2/PTHLH	2.24245048056449
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/306	38/9376	3.22531819745442	INSR/PIK3CB/SFN/PIK3R1	2.5246413484574
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	13/306	227/9376	1.75474360081771	EGFR/HLA-G/VEGFA/AKAP13/PTGS2/PTK2/PIK3CB/CREB5/AKT3/CREB3L2/PIK3R1/MDM2/IL1R1	2.11430804453868
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	6/306	75/9376	2.45124183006536	SERPINE1/THBS1/PERP/SFN/PPP1R13L/MDM2	2.31765242109946
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/306	95/9376	2.25772273821809	VEGFA/FLT1/HLA-DRB5/CCL20/HLA-DRB1/CXCL3/HLA-DQA1	2.26303899138731
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/306	39/9376	3.14261773085302	HLA-G/HLA-DRB5/HLA-DRB1/HLA-DQA1	2.46272560932386
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	5/306	59/9376	2.59665448100144	UPP1/UCK2/CTPS1/CDA/NT5E	2.25965225924239
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/306	99/9376	2.16650161748201	EGFR/PTK2/PIK3CB/AKT3/IGF1R/PIK3R1/MDM2	2.14309721657074
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/306	99/9376	2.16650161748201	KRT19/DEFB1/HLA-DRB5/KRT17/HLA-DRB1/KRT14/HLA-DQA1	2.14309721657074
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/306	99/9376	2.16650161748201	ITGA5/CACNA2D3/ITGB6/TPM1/ITGA6/ITGA2/PRKAG2	2.14309721657074
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/306	122/9376	2.00921461480767	IRS2/PLCG2/PTK2/PIK3CB/CREB5/AKT3/CREB3L2/PIK3R1	2.06082638830745
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	4/306	42/9376	2.91814503579209	TF/SAT1/CP/ACSL3	2.28831020302786
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	7/306	103/9376	2.08236563233708	SERPINE1/PIK3CB/AKT3/BDKRB2/TGFBR1/KNG1/PIK3R1	2.02873435784547
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	11/306	193/9376	1.74635104473568	PLCG2/PTK2/PIK3CB/TIAM1/AKT3/CCL20/CCL21/PIK3R1/CXCL3/VAV2/PARD3	1.92429749866483
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	8/306	125/9376	1.96099346405229	SGMS2/PIK3CB/AKT3/BDKRB2/KNG1/PIK3R1/PPP2R3A/CERS6	1.98666119036395
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	4/306	44/9376	2.78550207961973	HLA-G/HLA-DRB5/HLA-DRB1/HLA-DQA1	2.18042946132751
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	7/306	105/9376	2.04270152505447	PTGS2/PLCG2/CCL21/PPP1R13L/CXCL3/TNFAIP3/IL1R1	1.97348611728376
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/306	45/9376	2.72360203340595	HLA-G/HLA-DRB5/HLA-DRB1/HLA-DQA1	2.12873630923678
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	8/306	130/9376	1.88557063851181	EGFR/VEGFA/PIK3CB/CREB5/AKT3/CREB3L2/TGFBR1/PIK3R1	1.86750016300878
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	5/306	66/9376	2.32125173301644	GATA3/HLA-DRB5/HLA-DRB1/HLA-DQA1/SMAD3	1.97845148525386
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	11/306	201/9376	1.67684453549247	FLT1/ZBTB16/FOXO1/PTK2/JUP/MET/AFF1/IGF1R/PPARG/MDM2/PDGFA	1.78166737359245
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/306	155/9376	1.77912713472486	HLA-G/ITGA5/THBS1/HLA-DRB5/ITGA2/HLA-DRB1/HLA-DQA1/TUBB3/TUBA1C	1.79650270643466
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/306	88/9376	2.08912655971479	SERPINE1/BDKRB2/KNG1/SERPINC1/C7/TFPI	1.88539039213945
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/306	156/9376	1.76772247360483	EGFR/CLDN4/PIK3CB/AKT3/CLDN3/PIK3R1/YWHAZ/YWHAQ/CLDN7	1.77600343120874
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/306	48/9376	2.55337690631808	PIK3CB/AKT3/HK2/PIK3R1	1.98173647186431
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	11/306	205/9376	1.64412561772677	HLA-G/ACTN1/PIK3CB/CREB5/CREB3L2/ACTN4/PIK3R1/YWHAZ/YWHAQ/SND1/MDM2	1.71270223191871
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/306	49/9376	2.50126717353608	GALNT15/GALNT2/GALNT7/GALNT6	1.93520843373005
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/306	91/9376	2.02025425554837	PLCG2/PIK3CB/DAPP1/AKT3/PIK3R1/VAV2	1.79630825184802
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/306	31/9376	2.9652118912081	PFKP/ALDOB/PGM1	2.01299773067505
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	5/306	71/9376	2.15778330111387	EGFR/PLCG2/MET/F11R/CXCL3	1.79862644669825
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	7/306	116/9376	1.8489970700924	SLC38A1/SHANK2/PLA2G4A/SLC38A2/GLUL/HOMER1/SLC1A3	1.68994433899572
Human Diseases	Immune disease	hsa05310	Asthma	3/306	32/9376	2.87254901960784	HLA-DRB5/HLA-DRB1/HLA-DQA1	1.94887721286023
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	9/306	163/9376	1.69180801154818	PIK3CB/CREB5/AKT3/CREB3L2/TGFBR1/PIK3R1/YWHAZ/YWHAQ/SMAD3	1.63652092100799
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	6/306	94/9376	1.95577805590321	PTGS2/CCL20/LCN2/FOSL1/CXCL3/TNFAIP3	1.71057810091909
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/306	52/9376	2.35696329813977	PTGS2/INSR/PLA2G4A/IGF1R	1.8022347060187
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	8/306	142/9376	1.7262266408911	PLCG2/PIK3CB/AKT3/TGFBR1/FOSL1/PIK3R1/PPARG/IL1R1	1.60163710500225
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/306	75/9376	2.04270152505447	PIK3CB/AKT3/PIK3R1/MGST1/MDM2	1.66520814378521
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/306	75/9376	2.04270152505447	ALB/GPX3/CREB5/TTR/CREB3L2	1.66520814378521
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/306	54/9376	2.26966836117163	HLA-G/HLA-DRB5/HLA-DRB1/HLA-DQA1	1.71860209186976
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/306	98/9376	1.87595038015206	PLCG2/PIK3CB/PIP5K1B/MTMR1/PIK3R1/DGKI	1.60106169443275
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	9/306	169/9376	1.63174382178907	IRS2/PIK3CB/RRAS2/AKT3/OPTN/IGF1R/DAPK1/PIK3R1/ULK1	1.52218694190445
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/306	17/9376	3.60476739715494	PCDH7/MYH9	1.97433749022333
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/306	35/9376	2.62633053221289	PFKP/ALDOB/HK2	1.77047117098891
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/306	148/9376	1.65624447977389	EGFR/TCF7L2/PIK3CB/WNT7A/AKT3/IGF1R/PIK3R1/WNT6	1.47803744215361
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/306	36/9376	2.55337690631808	UGP2/UGT2B7/CRPPA	1.71513126802506
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/306	37/9376	2.48436671966084	TCF7L2/CDH1/PPARG	1.66163101890532
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/306	226/9376	1.49135288333623	CRH/PIK3CB/CREB5/TIAM1/RRAS2/AKT3/CREB3L2/AFDN/OXTR/PIK3R1/VAV2	1.37334575470911
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	6/306	104/9376	1.76772247360483	SGMS2/PLA2G4A/LPCAT1/LPIN1/PLAAT3/DGKI	1.44602872439551
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/306	105/9376	1.75088702147526	ITGA5/CACNA2D3/ITGB6/TPM1/ITGA6/ITGA2	1.42117861815975
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/306	82/9376	1.8683245655986	UPP1/UCK2/UGT2B7/CDA/MGST1	1.45054226580431
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	10/306	205/9376	1.49465965247888	HLA-G/PLCG2/PIK3CB/HLA-DRB5/AKT3/HLA-DRB1/PIK3R1/HLA-DQA1/MDM2/TNFAIP3	1.31527867783095
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/306	107/9376	1.71816016126077	FOXO1/PFKP/CREB5/AKT3/CREB3L2/PRKAG2	1.37226967230462
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/306	20/9376	3.0640522875817	UAP1/UGP2	1.69720105879675
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/306	63/9376	1.9454300238614	PLOD2/KMT2C/EZH2/AASS	1.38292163563909
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/306	89/9376	1.72137768965264	EGFR/PDGFD/TUBB3/TUBA1C/PDGFA	1.25592207807124
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/306	217/9376	1.41200566248005	EGFR/VEGFA/KLF5/PIK3CB/CREB5/AKT3/CREB3L2/UGT2B7/PIK3R1/MGST1	1.12785100328639
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/306	140/9376	1.53202614379085	SERPINE1/RRAS2/AKT3/CDH1/TGFBR1/PRKAG2/SMAD3	1.16492438871916
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/306	67/9376	1.82928494780997	PFKP/ALDOB/PGM1/HK2	1.25121625194634
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	8/306	166/9376	1.47665170485865	IRS2/INSR/KCNMA1/CREB5/AKT3/CREB3L2/BDKRB2/KNG1	1.13806767362935
NA	NA	hsa04081	Hormone signaling	10/306	219/9376	1.39911063359895	CRH/IRS2/INSR/THRB/PIK3CB/IGF1R/OXTR/DIO2/PIK3R1/PTHLH	1.09769442166525
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	7/306	142/9376	1.51044831077971	SMURF1/UBE2K/UBE2H/CUL1/BIRC7/MDM2/MID1	1.12575456296584
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/306	194/9376	1.4214675560946	KIF21A/TPM1/DNAH11/ACTG2/MYO5B/TUBB3/TUBA1C/KIF23/MYH9	1.08952971060231
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/306	24/9376	2.55337690631808	NDST1/HS3ST2	1.39950006832262
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	9/306	196/9376	1.40696278511405	HLA-G/VEGFA/TCF7L2/PTGS2/PLCG2/PIK3CB/AKT3/PIK3R1/CXCL3	1.05755776849266
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/306	70/9376	1.75088702147526	IRS2/ACSL3/AKT3/PRKAG2	1.15820330998879
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/306	70/9376	1.75088702147526	PTGS2/UGT2B7/CYP3A5/MGST1	1.15820330998879
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	4/306	70/9376	1.75088702147526	HLA-G/HLA-DRB5/HLA-DRB1/HLA-DQA1	1.15820330998879
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/306	26/9376	2.35696329813977	PLA2G4A/PLAAT3	1.2725992937807
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/306	26/9376	2.35696329813977	APOB/APOA1	1.2725992937807
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/306	49/9376	1.87595038015206	CREB5/CREB3L2/MAOA	1.12914382801468
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/306	73/9376	1.67893276031874	UGT2B7/MAOA/CYP3A5/MGST1	1.06959507010231
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/306	50/9376	1.83843137254902	SAT1/CKB/MAOA	1.09181114945067
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/306	50/9376	1.83843137254902	HLA-DRB5/HLA-DRB1/HLA-DQA1	1.09181114945067
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	9/306	205/9376	1.34519368723099	MT-ATP8/INSR/PIK3CB/AKT3/TGFBR1/PDK4/PIK3R1/GFPT1/SMAD3	0.917855123743198
Organismal Systems	Immune system	hsa04611	Platelet activation	6/306	126/9376	1.45907251789605	PLCG2/PIK3CB/PLA2G4A/AKT3/ITGA2/PIK3R1	0.952880432732409
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/306	51/9376	1.80238369857747	PLA2G4A/LPCAT1/PLAAT3	1.05532316818462
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	8/306	180/9376	1.36180101670298	HLA-G/ITGA5/PIK3CB/HLA-DRB5/AKT3/HLA-DRB1/PIK3R1/HLA-DQA1	0.90022125358329
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/306	154/9376	1.39275103980986	EGFR/CACNA2D3/PTGS2/PLA2G4A/PPP1R12B/OXTR/PRKAG2	0.902626028574327
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/306	128/9376	1.43627450980392	ADK/GDA/PGM1/NT5E/ATIC/AK4	0.912816793544762
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	7/306	155/9376	1.38376554923044	EGFR/CRH/TCF7L2/CREB5/WNT7A/CREB3L2/WNT6	0.884882347310812
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	4/306	78/9376	1.57130886542651	PLCG2/PIK3CB/PIP5K1B/MTMR1	0.930606757341779
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	4/306	78/9376	1.57130886542651	PTGS2/HLA-DRB5/HLA-DRB1/HLA-DQA1	0.930606757341779
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	7/306	157/9376	1.36613796261604	IRS2/INSR/PIK3CB/AKT3/PRKAG2/PIK3R1/PPARG	0.849758245123963
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/306	30/9376	2.04270152505447	PLA2G4A/PLAAT3	1.05063159193062
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/306	158/9376	1.35749151981468	SFN/WEE1/CUL1/YWHAZ/YWHAQ/SMAD3/MDM2	0.832374263629784
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/306	55/9376	1.67130124777184	SGMS2/HEXB/CERS6	0.917086400006886
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	12/306	298/9376	1.23384655875773	IL1RL1/INHBA/IL1RAP/INHA/CCL20/CCL21/TGFBR1/CXCL3/TNFRSF12A/LIFR/CLCF1/IL1R1	0.753506033287996
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	6/306	134/9376	1.37196371085748	KCNMA1/PLA2G4A/PPP1R12B/ACTG2/ADM/MYH9	0.796549366853444
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	9/306	216/9376	1.27668845315904	APOB/APOA1/PTK2/PIK3CB/AKT3/PIK3R1/CXCL3/VAV2/PPARG	0.755636420496785
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/306	82/9376	1.49465965247888	HLA-G/HLA-DRB5/HLA-DRB1/HLA-DQA1	0.826332412482245
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	10/306	248/9376	1.23550495467004	TCF7L2/ANXA2/AHNAK/PIK3CB/AKT3/CYTH3/TUBB3/TUBA1C/AHNAK2/TXN	0.690368204054332
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	12/306	308/9376	1.19378660555131	MT-ATP8/GPX3/DNAH11/CREB5/RCOR1/CREB3L2/CLTB/ULK1/SLC1A3/PPARG/TUBB3/TUBA1C	0.63516427916476
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	7/306	168/9376	1.27668845315904	EGFR/PIK3CB/AKT3/PIK3R1/LIFR/CLCF1/PDGFA	0.664669466825618
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/306	60/9376	1.53202614379085	CRH/PLA2G4A/IGF1R	0.759340505808922
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/306	115/9376	1.33219664677465	PIK3CB/CREB5/AKT3/CREB3L2/PIK3R1	0.658351652965966
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	9/306	227/9376	1.2148224928738	MT-ATP8/EGFR/VEGFA/PTK2/PIK3CB/MET/AKT3/PIK3R1/MGST1	0.601794999439326
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/306	143/9376	1.28561634443987	ACTN1/HLA-DRB5/ACTN4/C7/HLA-DRB1/HLA-DQA1	0.632153235722114
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/306	12/9376	2.55337690631808	NECTIN4	0.988961699879737
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/306	144/9376	1.27668845315904	TCF7L2/FOXO1/AKT3/LPIN1/PRKAG2/CXCL3	0.614563964562427
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/306	90/9376	1.36180101670298	EGFR/PIK3CB/AKT3/PIK3R1	0.633460305523265
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/306	63/9376	1.45907251789605	PTGS2/PLA2G4A/PLAAT3	0.671505348151318
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	3/306	63/9376	1.45907251789605	TCF7L2/WNT7A/WNT6	0.671505348151318
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	2/306	37/9376	1.65624447977389	GLUL/GFPT1	0.734613737383465
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/306	37/9376	1.65624447977389	APOA1/KNG1	0.734613737383465
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/306	13/9376	2.35696329813977	RAD50	0.899238668327791
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	5/306	120/9376	1.27668845315904	PLCG2/PIK3CB/AKT3/GAB1/PIK3R1	0.560289770474469
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/306	65/9376	1.41417797888386	MGLL/LPIN1/DGKI	0.615443554067898
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	3/306	65/9376	1.41417797888386	PIK3CB/AKT3/PIK3R1	0.615443554067898
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	4/306	93/9376	1.31787195164804	GATA3/HLA-DRB5/HLA-DRB1/HLA-DQA1	0.565838137203534
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/306	122/9376	1.25575913425479	PIK3CB/AKT3/PIK3R1/VAV2/PPP2R3A	0.522262723101167
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/306	68/9376	1.3517877739331	UGT2B7/RDH13/CYP3A5	0.534748677064552
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	14/306	388/9376	1.10558587696247	MT-ATP8/MME/IRS2/PTGS2/INSR/PIK3CB/WNT7A/CAPN2/AKT3/PIK3R1/ULK1/TUBB3/TUBA1C/WNT6	0.390151130999477
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/306	154/9376	1.19378660555131	RFK/CTPS1/UGP2/UGT2B7/RDH13/AK4	0.445363134479185
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/306	154/9376	1.19378660555131	CACNA2D3/TPM1/CREB5/AKT3/CREB3L2/PPP2R3A	0.445363134479185
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/306	15/9376	2.04270152505447	HEXB	0.74231326871513
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/306	15/9376	2.04270152505447	AK4	0.74231326871513
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/306	69/9376	1.33219664677465	CREB5/CREB3L2/MAOA	0.508695201125176
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	8/306	214/9376	1.14544010750718	HLA-G/PLCG2/PTK2/PIK3CB/AKT3/WEE1/PIK3R1/CUL1	0.395310761967825
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/306	71/9376	1.29466998066832	PIK3CB/AKT3/PIK3R1	0.457772382593709
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/306	43/9376	1.42514059887521	APOB/APOA1	0.513214458208225
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/306	16/9376	1.91503267973856	MAOA	0.672823853043282
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/306	16/9376	1.91503267973856	HEXB	0.672823853043282
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	4/306	101/9376	1.2134860544878	TCF7L2/WNT7A/CREB3L2/WNT6	0.396201345987304
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	2/306	44/9376	1.39275103980986	MAN2A1/HEXB	0.479621921443423
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/306	44/9376	1.39275103980986	CREB5/CREB3L2	0.479621921443423
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/306	17/9376	1.80238369857747	BAAT	0.608183371527097
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/306	17/9376	1.80238369857747	BAAT	0.608183371527097
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/306	17/9376	1.80238369857747	GLUL	0.608183371527097
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/306	103/9376	1.18992321847833	MME/COL17A1/SLC38A2/COL12A1	0.355982994256405
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	5/306	133/9376	1.15189935623372	HLA-G/PLCG2/PIK3CB/PIK3R1/VAV2	0.324054446627023
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	5/306	133/9376	1.15189935623372	CREB5/AKT3/CREB3L2/MAOA/PPP2R3A	0.324054446627023
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	3/306	75/9376	1.22562091503268	PFKP/ALDOB/GLUL	0.360319589156699
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/306	46/9376	1.33219664677465	CP/UGT2B7	0.414835625774145
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	9/306	254/9376	1.08568781843446	EGFR/VEGFA/FLT1/PLCG2/PDGFD/MET/BDKRB2/OXTR/PDGFA	0.254292539159008
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	4/306	105/9376	1.16725801431684	RRAS2/SMURF1/OPTN/ULK1	0.316563619911735
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/306	18/9376	1.70225127087872	ACSL3	0.547746957425418
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/306	18/9376	1.70225127087872	HEXB	0.547746957425418
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	5/306	137/9376	1.1182672582415	PIK3CB/CAPN2/AKT3/PIK3R1/TUBA1C	0.256126807776918
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/306	19/9376	1.61265909872721	HEXB	0.490987099490421
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/306	79/9376	1.16356415984115	UGT2B7/CYP3A5/MGST1	0.268147026423602
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/306	110/9376	1.11420083184789	PIK3CB/AKT3/IGF1R/PIK3R1	0.221290194197233
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/306	50/9376	1.22562091503268	THBS1/MET	0.29380512066602
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	6/306	173/9376	1.06267709395897	PIK3CB/HLA-DRB5/AKT3/HLA-DRB1/PIK3R1/HLA-DQA1	0.152830453051909
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/306	51/9376	1.20158913238498	PLCG2/TJP2	0.265137093683821
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/306	22/9376	1.39275103980986	MAOA	0.338744856061449
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/306	53/9376	1.15624614625725	CLTB/BDKRB2	0.209513549738604
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/306	23/9376	1.33219664677465	GLUL	0.292972193774715
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/306	23/9376	1.33219664677465	CRPPA	0.292972193774715
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/306	23/9376	1.33219664677465	MME	0.292972193774715
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/306	86/9376	1.06885544915641	KCNMA1/CREB5/CREB3L2	0.117820915270475
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/306	56/9376	1.09430438842204	SMURF1/CUL1	0.130005183370868
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/306	89/9376	1.03282661379158	SLC38A1/SLC38A2/GLUL	0.0571512948078841
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/306	59/9376	1.03866179240058	GPX3/MGST1	0.0547157870308468
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/306	157/9376	0.975812830440032	THBS1/PTGS2/PTK2/DOCK1/PPARG	-0.0561352518950564
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/306	27/9376	1.13483418058581	BAAT	0.12886708663144
Organismal Systems	Digestive system	hsa04978	Mineral absorption	2/306	61/9376	1.00460730740384	TF/SLC34A2	0.00663076116982458
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/306	28/9376	1.09430438842204	ST3GAL6	0.0917897685282885
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/306	62/9376	0.988403963736032	TLE1/CTBP2	-0.0168259657557712
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/306	98/9376	0.93797519007603	CREB5/DAGLB/CREB3L2	-0.113368918518536
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	1/306	30/9376	1.02135076252723	ATIC	0.0215131416651068
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/306	65/9376	0.942785319255907	CREB5/CREB3L2	-0.0850175727760703
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/306	100/9376	0.91921568627451	CCL20/CCL21/CXCL3	-0.149172709414329
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/306	66/9376	0.928500693206576	UGT2B7/CYP3A5	-0.107063556614697
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/306	31/9376	0.988403963736032	UGT2B7	-0.0118780039896071
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/306	31/9376	0.988403963736032	GLUL	-0.0118780039896071
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/306	31/9376	0.988403963736032	IMMP2L	-0.0118780039896071
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	5/306	168/9376	0.91192032368503	PLA2G4A/CAPN2/GLUL/TNFAIP3/CHMP4C	-0.211587693038977
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	7/306	235/9376	0.912696426088166	MT-ATP8/MGLL/CREB5/ACSL3/CREB3L2/PRKAG2/PPARG	-0.248949814603364
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/306	136/9376	0.901191849288735	PIK3CB/AKT3/PIK3R1/TNFAIP3	-0.213191039718082
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/306	32/9376	0.957516339869281	BIRC7	-0.0442153643406335
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	7/306	238/9376	0.901191849288735	RPS4Y1/EGFR/PLCG2/PIK3CB/RPLP0/C7/PIK3R1	-0.283594876638082
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	4/306	138/9376	0.888131097849768	IGF1R/CUL1/YWHAZ/YWHAQ	-0.243165886545313
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	8/306	275/9376	0.891360665478312	MT-ATP8/PIK3CB/CREB5/CREB3L2/C7/PIK3R1/TUBB3/TUBA1C	-0.335854826846541
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/306	73/9376	0.83946638015937	ELL/NUP153	-0.252905704957596
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	3/306	109/9376	0.84331714337111	PIK3CB/AKT3/PIK3R1	-0.30220932186682
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	4/306	144/9376	0.851125635439361	PIK3CB/AKT3/PIK3R1/ULK1	-0.33067089956771
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/306	37/9376	0.828122239886946	MAOA	-0.192403544138388
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	5/306	181/9376	0.846423283862348	HLA-DRB5/KSR1/AKT3/HLA-DRB1/HLA-DQA1	-0.383205298709883
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/306	76/9376	0.806329549363605	EZR/KCNJ16	-0.311366147234533
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/306	38/9376	0.806329549363605	NT5E	-0.219720680040426
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/306	39/9376	0.785654432713256	ATIC	-0.246368874018398
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	3/306	115/9376	0.799317988064791	PTGS2/PLA2G4A/MAOA	-0.397714232099714
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/306	79/9376	0.775709439894101	CLTB/SLC1A3	-0.367701865773589
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/306	116/9376	0.792427315753888	PFKP/ALDOB/HK2	-0.413177259414669
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/306	41/9376	0.747329826239439	MAOA	-0.297804635933954
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	1/306	41/9376	0.747329826239439	RAD50	-0.297804635933954
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/306	42/9376	0.729536258948024	MAOA	-0.322658050694663
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/306	83/9376	0.738325852429325	ACSL3/BAAT	-0.439809497578084
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/306	43/9376	0.712570299437604	ACSL3	-0.346974808892297
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	1/306	45/9376	0.680900508351489	DEFB1	-0.394104126686879
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/306	87/9376	0.704379836225678	CACNA2D3/TPM1	-0.508805627478763
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/306	90/9376	0.680900508351489	UGT2B7/BAAT	-0.558696222896272
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/306	93/9376	0.658935975824021	EGFR/PLA2G4A	-0.607121927890504
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/306	56/9376	0.547152194211018	MAN2A1	-0.624282316186839
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/306	56/9376	0.547152194211018	CXCL3	-0.624282316186839
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/306	57/9376	0.53755303290907	ACSL3	-0.643216853751852
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	2/306	103/9376	0.594961609239165	MSI2/PPP2R3A	-0.75918458146964
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	9/306	368/9376	0.749360613810742	MT-ATP8/GPX3/DNAH11/OPTN/NRG2/ULK1/NUP153/TUBB3/TUBA1C	-0.900952193122327
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/306	149/9376	0.616923279378866	PTGS2/MGLL/DAGLB	-0.865747692606002
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/306	191/9376	0.641686342949047	CRH/CREB5/CREB3L2/MAOA	-0.918931571523492
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/306	195/9376	0.628523546170605	PLCG2/PIK3CB/AKT3/PIK3R1	-0.962822678003994
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/306	117/9376	0.523769621808838	MORF4L2/MBD2	-0.952073970577605
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/306	69/9376	0.444065548924884	KCNMA1	-0.851306568407088
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	11/306	480/9376	0.702178649237473	MT-ATP8/GPX3/PTGS2/DNAH11/WNT7A/CAPN2/OPTN/ULK1/TUBB3/TUBA1C/WNT6	-1.230330438161
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/306	78/9376	0.392827216356628	PFKP	-0.989025603358541
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	1/306	78/9376	0.392827216356628	ITGA5	-0.989025603358541
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/306	83/9376	0.369162926214663	EZH2	-1.06028103674331
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/306	268/9376	0.571651546190616	MT-ATP8/MAOA/TUBB3/TUBA1C/TXN	-1.30675989562653
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/306	187/9376	0.491559190521128	CXCL3/TNFAIP3/TXN	-1.2899408221825
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/306	93/9376	0.329467987912011	KCNMA1	-1.19360196043752
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/306	102/9376	0.300397283096245	KCNMA1	-1.30485043716764
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/306	108/9376	0.283708545146454	NUP153	-1.3751540217045
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/306	174/9376	0.352189918112839	CAPN2/CUL1	-1.58425074582433
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	6/306	370/9376	0.496873343932167	CRH/THRB/BDKRB2/KNG1/OXTR/ADM	-1.81365603705551
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/306	138/9376	0.222032774462442	MT-ATP8	-1.69104269788032
Genetic Information Processing	Translation	hsa03010	Ribosome	2/306	222/9376	0.276040746628982	RPS4Y1/RPLP0	-2.00506226896319
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/306	250/9376	0.245124183006536	CLTB/HEXB	-2.22202014862295
NA	NA	hsa04082	Neuroactive ligand signaling	1/306	199/9376	0.153972476762899	SLC1A3	-2.21566130005018