category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	79/1163	233/9376	2.73343690839512	THBS1/ACTG2/DES/ITGA7/SYNPO2/TPM1/THBS2/CSRP1/MYL9/LMOD1/PDLIM3/DMD/TPM2/PDLIM1/TMOD1/LMNA/PDLIM2/SGCD/MYH11/TPM4/FHL1/ITGA5/SSPN/SDC4/COL6A3/ITGB1/DAAM1/MYH9/COL6A2/FBN1/FLNC/VCL/THBS3/DAAM2/ITGA11/FHL3/COL4A2/CSRP2/COMP/SYNE1/PDLIM7/PDLIM4/NID1/ZYX/COL4A1/SNTA1/ATP1A1/ITGAV/BGN/ITGB3/LDB3/TLN2/VIM/TLN1/HSPG2/FHL2/COL5A2/SUN2/DTNA/ELN/COL5A1/COL1A1/ANK2/COL6A1/THBS4/ATP1B2/ENO2/ITGA1/ACTG1/PLEC/SNTB2/CAPN3/PDLIM5/XIRP1/TMOD2/COL1A2/INF2/SGCA/SDC2	10.0824534161461
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	60/1163	203/9376	2.3828302038638	THBS1/LAMA3/TNC/ITGA7/THBS2/MYL9/ACTN1/LAMB1/FLNA/EMP1/VEGFA/MYLK/ITGA5/COL6A3/ITGB1/COL6A2/CAPN2/BCL2/VCL/THBS3/ITGA11/AKT3/COL4A2/COMP/PPP1R12B/ZYX/PDGFA/COL4A1/ITGAV/PARVA/PPP1R12C/PDGFRB/ITGB3/TLN2/EMP2/TLN1/EGFR/COL1A1/MAPK10/VEGFB/PIK3R1/COL6A1/THBS4/PDGFD/RELN/ITGA1/ACTG1/ROCK1/MAP2K1/ELK1/ACTN4/PTEN/LAMB3/PIP5K1B/SRC/PDGFRA/ROCK2/PIP5K1A/COL1A2/PRKCG	7.4952437892313
NA	NA	hsa04518	Integrin signaling	49/1163	154/9376	2.56515281794731	THBS1/LAMA3/TNC/ITGA7/THBS2/ACTN1/LAMB1/FLNA/VEGFA/ITGA5/COL6A3/ITGB1/COL6A2/FBN1/VCL/THBS3/ITGA11/AKT3/COL4A2/COMP/PDGFA/COL4A1/ITGAV/PARVA/PDGFRB/ITGB3/TLN2/NPNT/TLN1/EGFR/COL1A1/VEGFB/PIK3R1/COL6A1/THBS4/PDGFD/RELN/ITGA1/ACTG1/ITGAE/LIMS2/LIMS1/ACTN4/LAMB3/SRC/PDGFRA/FERMT2/COL1A2/ARHGEF6	7.36934914650069
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	29/1163	89/9376	2.62691412175022	THBS1/LAMA3/TNC/ITGA7/THBS2/LAMB1/CD44/ITGA5/SDC4/COL6A3/ITGB1/COL6A2/THBS3/ITGA11/COL4A2/COMP/COL4A1/ITGAV/ITGB3/NPNT/HSPG2/COL1A1/COL6A1/THBS4/RELN/ITGA1/GP1BB/LAMB3/COL1A2	5.80291880053639
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	42/1163	157/9376	2.15668899343341	SERPINE1/BMP8A/CCN2/MYC/BMP8B/SMAD3/PPP2R1B/BMP2/TEAD3/TEAD4/YWHAG/GLI2/RASSF1/DLG2/WTIP/PARD3/TCF7L1/TP53BP2/WNT9A/DLG5/YWHAQ/YAP1/BBC3/FZD8/PPP2R2D/TCF7L2/ACTG1/FZD10/SMAD7/TGFBR1/LATS2/STK3/PPP2CA/TEAD2/WNT5B/CSNK1D/FRMD6/SAV1/BMPR1A/PRKCI/CTNNA1/WNT5A	5.49982797715258
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	66/1163	300/9376	1.77361994840929	NR4A1/CACNB2/HSPB1/FLNA/NGF/VEGFA/CACNA1H/NTRK2/NFATC1/INSR/GADD45B/MYC/AKT3/MAPKAPK2/DDIT3/HSPA1B/RELB/MAP3K5/PDGFA/FGF7/IL1R1/DUSP16/HSPA1A/PDGFRB/CACNA1C/JUND/GNG12/MRAS/RASGRP2/ANGPT2/EGFR/ANGPT4/RELA/RRAS/MAPK10/VEGFB/CSF1/DUSP8/GADD45A/PDGFD/PPP3CC/FLT3LG/IL1RAP/SRF/PLA2G4C/MAP2K3/FGF2/MAP2K1/ELK1/DUSP1/DAXX/ECSIT/DUSP5/TGFBR1/STK3/PDGFRA/MAP3K6/NTRK1/CACNA2D1/PRKCG/PLA2G4A/PPM1B/MAP3K13/NTF3/CACNA2D3/MAP3K10	5.12466673440133
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	76/1163	362/9376	1.69255545051614	THBS1/LAMA3/TNC/ITGA7/NR4A1/THBS2/CDKN1A/LAMB1/NGF/VEGFA/IL6R/OSMR/F2R/ITGA5/COL6A3/ITGB1/CREB5/COL6A2/NTRK2/BCL2/INSR/MYC/THBS3/ITGA11/CREB3L2/AKT3/COL4A2/COMP/FOXO3/CSF3/PDGFA/FGF7/COL4A1/ITGAV/HSP90AA1/PPP2R1B/PDGFRB/DDIT4/ITGB3/GNG12/MCL1/GNB5/YWHAG/ANGPT2/EGFR/ANGPT4/IL4R/RELA/GYS1/COL1A1/VEGFB/PHLPP2/CSF1/JAK1/PIK3R1/COL6A1/THBS4/YWHAQ/PDGFD/RELN/PPP2R2D/ITGA1/FLT3LG/PRLR/MAGI2/HSP90AB1/BCL2L11/FGF2/MAP2K1/PTEN/LAMB3/PDGFRA/PPP2CA/NTRK1/COL1A2/NTF3	5.05678680551817
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	32/1163	110/9376	2.34528257640897	SERPINE1/CDKN1A/TIMP1/VEGFA/IL6R/BCL2/INSR/PFKFB3/AKT3/PFKP/STAT3/TF/LDHA/HK1/GAPDH/HK2/ANGPT2/EGFR/ANGPT4/RELA/ALDOA/PIK3R1/NPPA/ENO2/HIF1A/CAMK2D/PFKM/ALDOB/MAP2K1/ALDOC/HMOX1/PRKCG	5.34057841588678
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	32/1163	110/9376	2.34528257640897	THBS1/BMP8A/NBL1/INHBA/FBN1/ID4/MYC/BMP8B/INHBB/SMAD3/TF/PPP2R1B/LRRC32/BMP2/SMURF1/RGMA/CHRD/LTBP1/SKIL/ACVR1B/SKI/ACVR1/NEO1/ROCK1/LEFTY2/SMAD7/TGFBR1/SIN3A/PPP2CA/LEMD3/BMPR1A/ZFYVE9	5.34057841588678
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	31/1163	105/9376	2.38018261474839	DES/ITGA7/TPM1/CACNB2/DMD/TPM2/LMNA/SGCD/TPM4/PLN/ITGA5/SSPN/ITGB1/ITGA11/ADCY1/SNTA1/ITGAV/CACNA1C/ITGB3/ADCY5/DTNA/ADCY6/ADCY3/AGT/ITGA1/ACTG1/SNTB2/CACNA2D1/SGCA/CACNA2D3/SLC8A2	5.3517090635546
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	49/1163	204/9376	1.93643889197984	THBS1/TIMP3/CDKN1A/FLNA/ESR1/VEGFA/HOXD10/CD44/ITGA5/SDC4/ITGB1/PLCE1/MYC/AKT3/PPP1R12B/GPC1/STAT3/ITGAV/PPP1R12C/ITGB3/MRAS/HSPB2/HSPG2/EGFR/RRAS/COL1A1/ANK2/PIK3R1/WNT9A/FZD8/CTTN/HIF1A/CAMK2D/ACTG1/FZD10/ROCK1/FGF2/MAP2K1/ELK1/PTPN11/TWIST2/SRC/ROCK2/WNT5B/COL1A2/SLC9A1/PRKCG/SDC2/WNT5A	5.0884684634838
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	15/1163	34/9376	3.55672449547317	NFIL3/RORA/BHLHE40/PER1/RORB/PER2/PRKAB2/CRY1/CRY2/PRKAG2/NPAS2/NR1D2/NR1D1/PRKAG1/CSNK1D	5.6198929566793
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	70/1163	333/9376	1.69469555540063	THBS1/LAMA3/TNC/ITGA7/THBS2/CDKN1A/LAMB1/VEGFA/FOXO1/ITGA5/COL6A3/ITGB1/CREB5/COL6A2/THBS3/ITGA11/CREB3L2/AKT3/COL4A2/COMP/COL4A1/NOTCH3/HEYL/ITGAV/PPP2R1B/PDGFRB/PKM/ITGB3/EGFR/RELA/HLA-F/DLG2/COL1A1/IRF1/HLA-B/PTGS2/PARD3/TUBG2/HES1/TCF7L1/JAK1/PIK3R1/COL6A1/WNT9A/THBS4/FZD8/RELN/HES6/PPP2R2D/ITGA1/TCF7L2/HES4/FZD10/MAP2K1/TRAF3/PTEN/LAMB3/STAT2/PPP2CA/CHD4/WNT5B/NFX1/HEY2/TADA3/COL1A2/JAG1/PRKCI/CSNK1A1/HLA-G/WNT5A	4.85718847416246
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	29/1163	99/9376	2.36156926096737	DES/ITGA7/TPM1/CACNB2/DMD/TPM2/LMNA/SGCD/TPM4/ITGA5/SSPN/ITGB1/ITGA11/SNTA1/ITGAV/CACNA1C/ITGB3/PRKAB2/DTNA/PRKAG2/AGT/ITGA1/ACTG1/SNTB2/PRKAG1/CACNA2D1/SGCA/CACNA2D3/SLC8A2	5.12481439603604
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	23/1163	71/9376	2.61160427742725	SLC7A5/MYC/AKT3/PFKP/NTRK3/LDHA/HK1/PDGFRB/PKM/HK2/EGFR/GLS/SLC1A5/PIK3R1/HIF1A/PFKM/MAP2K1/PTEN/PDGFRA/NTRK1/G6PD/SCO2/SLC16A3	5.12925134698136
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	38/1163	154/9376	1.9893021853469	MYL9/CACNB2/CDKN1A/MYLK/NFATC1/ADCY1/OXTR/PPP1R12B/PPP1R12C/CACNA1C/PRKAB2/ADCY5/EGFR/GNAO1/CAMK1/EEF2/NFATC4/ADCY6/PTGS2/ADCY3/PRKAG2/NPPA/PPP3CC/CAMK2D/ACTG1/MYL6B/PLA2G4C/ROCK1/MAP2K1/ELK1/PRKAG1/SRC/ROCK2/CAMK1D/CACNA2D1/PRKCG/PLA2G4A/CACNA2D3	4.65802005505052
Organismal Systems	Digestive system	hsa04978	Mineral absorption	20/1163	61/9376	2.64324880537897	MT2A/MT1M/MT1G/MT1X/MT1A/MT1E/MT1F/SLC30A1/HEPH/CYBRD1/ATP1A1/ATP2B4/TF/MT1H/HMOX2/ATP1B2/STEAP2/HMOX1/VDR/SLC8A2	4.84508496367817
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	25/1163	86/9376	2.34357815593193	DES/ITGA7/CACNB2/DMD/LMNA/SGCD/ITGA5/SSPN/ITGB1/ITGA11/SNTA1/ITGAV/CACNA1C/ITGB3/DTNA/TCF7L1/ITGA1/TCF7L2/ACTG1/SNTB2/CACNA2D1/SGCA/CTNNA1/CACNA2D3/SLC8A2	4.71008654592123
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	33/1163	137/9376	1.94191965154301	LMNA/NGF/CAPN2/BCL2/GADD45B/AKT3/ERN1/DDIT3/MAP3K5/CTSK/DAB2IP/MCL1/CTSF/EIF2AK3/PTPN13/RELA/MAPK10/TUBA1C/PIK3R1/GADD45A/NFKBIA/BBC3/ACTG1/BCL2L11/MAP2K1/DAXX/TRAF1/TUBA4A/SEPTIN4/NTRK1/CYCS/NOL3/RIPK1	4.17913347427601
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	28/1163	109/9376	2.07094906403086	GFPT2/FOXO1/CREB5/INSR/CREB3L2/AKT3/PPP1R3B/STAT3/PTPN1/PRKAB2/SLC2A4/PYGM/RELA/PPARGC1A/GYS1/MAPK10/IRS2/PIK3R1/PRKAG2/NR1H2/NFKBIA/AGT/PYGB/SOCS3/PTPN11/PTEN/PRKAG1/SLC27A5	4.23191627767756
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	32/1163	134/9376	1.92523196570886	CALD1/ACTG2/ACTA2/MYL9/RAMP1/AVPR1A/MYH11/MYLK/MYH9/KCNMA1/ADCY1/PPP1R12B/PTGIR/EDNRA/PPP1R12C/CACNA1C/KCNMB1/ADCY5/ADCY6/ADCY3/NPPA/ADM/AGT/MYL6B/PLA2G4C/ROCK1/MAP2K1/PLA2G6/ROCK2/PRKCG/PLA2G4A/PRKG1	4.05923907013874
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	37/1163	166/9376	1.79693149209046	MYL9/ADRA2C/PLN/MYLK/CREB5/NFATC1/INSR/CREB3L2/KCNJ8/AKT3/KCNMA1/ADCY1/ATP1A1/ATP2B4/EDNRA/CACNA1C/KCNMB1/ADCY5/ADRA2A/MEF2D/NFATC4/ADCY6/IRS2/ADCY3/NPPA/ATP1B2/PPIF/PPP3CC/SRF/ROCK1/MAP2K1/ADRA2B/SLC25A4/ROCK2/PRKG1/PDE5A/SLC8A2	3.89825102822711
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	50/1163	248/9376	1.62538485008182	MYL9/FLNA/BCL2/TUBB3/DYNC1I1/MYC/AKT3/TUBB6/HSP90AA1/WASF3/KIF5C/GAPDH/AHNAK/DCTN2/DYNC2H1/KLC1/RAB9B/RELA/RRAS/PLEKHM2/MAPK10/TCF7L1/TUBA1C/CYFIP2/SNX33/NFKBIA/TCF7L2/DYNLT3/ACTG1/HSP90AB1/MAP2K3/STX10/FHOD1/ANXA2/MAP2K1/FYCO1/DYNC1LI1/DYNLRB2/DYNC2LI1/TUBA4A/RAB7A/ROCK2/TUBB4B/NOD1/AHNAK2/CYCS/DYNC1H1/PLEKHM1/RIPK1/DYNC1LI2	3.75586492598964
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	24/1163	93/9376	2.08049260810473	LAMA3/CDKN1A/LAMB1/ITGB1/BCL2/GADD45B/MYC/AKT3/COL4A2/COL4A1/ITGAV/TRAF5/RELA/PTGS2/PIK3R1/GADD45A/NFKBIA/ZBTB17/TRAF3/PTEN/TRAF1/LAMB3/CYCS/E2F3	3.94043060302646
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	35/1163	157/9376	1.79724082786118	SERPINE1/CDKN1A/FOXO1/HIPK2/CAPN2/NFATC1/GADD45B/MYC/AKT3/MAPKAPK2/FOXO3/SMAD3/ZFP36L2/MRAS/HIPK3/SQSTM1/RELA/NFATC4/RRAS/RAD9A/HLA-F/HLA-B/PIK3R1/GADD45A/PPP3CC/MAP2K3/MAP2K1/TRAF3IP2/PTEN/TGFBR1/MCU/IGFBP3/SLC25A4/E2F3/HLA-G	3.79072286024273
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	19/1163	67/9376	2.28621295927927	ADH1B/PFKP/LDHA/HK1/PKM/GPI/GAPDH/HK2/ALDOA/ADH5/TPI1/ENO2/ALDH1B1/PFKM/ALDH2/ALDOB/ALDOC/PGM2/ALDH3A2	3.97578921577022
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	47/1163	232/9376	1.63323153556498	ITGA7/MYL9/ACTN1/MYH11/ENAH/MYLK/F2R/ITGA5/ITGB1/MYH9/GSN/VCL/ITGA11/AKT3/PPP1R12B/PDGFA/FGF7/CXCL12/ITGAV/PPP1R12C/PDGFRB/ITGB3/GNG12/MRAS/ARHGEF7/EGFR/CFL2/RRAS/WASF1/PIK3R1/CYFIP2/SSH1/PDGFD/ITGA1/ACTG1/ITGAE/ROCK1/FGF2/MAP2K1/ACTN4/PIP5K1B/SRC/PDGFRA/ROCK2/PIP5K1A/SLC9A1/ARHGEF6	3.67504789109813
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	23/1163	90/9376	2.06026559663705	FOXO1/CREB5/INSR/CREB3L2/AKT3/ADCY1/FOXO3/SOD2/PRKAB2/ULK1/ATG101/ADCY5/RELA/ADCY6/PPARGC1A/IRS2/ADCY3/PIK3R1/PRKAG2/RB1CC1/SESN2/ADIPOR2/PRKAG1	3.80317376814004
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/1163	21/9376	3.45510379560251	XYLT1/CHST15/CHST7/CHST3/DSEL/CHSY3/CHSY1/CHPF/UST	4.23820728179497
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	43/1163	212/9376	1.63519849445968	THBS1/CNR1/NGF/ENAH/VEGFA/F2R/ITGB1/PLCE1/INSR/AKT3/ADCY1/PDGFA/FGF7/PDGFRB/ITGB3/MRAS/TLN2/RASGRP2/ADCY5/TLN1/ANGPT2/EGFR/ANGPT4/GNAO1/RRAS/ADCY6/PARD3/PRKD1/VEGFB/ADCY3/CSF1/PIK3R1/GRIN2A/PDGFD/MAGI2/ACTG1/MAP2K3/FGF2/MAP2K1/SRC/PDGFRA/PRKCG/PRKCI	3.52013593274931
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	36/1163	169/9376	1.71732969722255	BCL2/VMP1/AKT3/ERN1/MAP1LC3A/UBC/CALCOCO2/DDIT4/MRAS/ULK1/ATG101/GABARAPL1/EIF2AK3/SQSTM1/RRAS/MAPK10/BECN1/IRS2/PIK3R1/OPTN/DAPK3/WDR45/RB1CC1/MAP1LC3B/HIF1A/RRAGC/MAP2K1/TP53INP2/ZFYVE1/IGBP1/PTEN/PPP2CA/RAB7A/RUBCN/PLEKHM1/BNIP3	3.54101426029892
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	45/1163	227/9376	1.59817576448574	CDKN1A/VEGFA/PTGER3/IL6R/CREB5/NFATC1/MYC/AKAP13/CREB3L2/AKT3/ADCY1/IL1R1/CXCL12/STAT3/ITGAV/ITGB3/GNG12/ADCY5/GNB5/TRAF5/EGFR/GNAO1/RELA/NFATC4/ADCY6/HLA-F/CCL2/HLA-B/PTGS2/ADCY3/JAK1/PIK3R1/NFKBIA/PPP3CC/ROCK1/MAP2K1/ELK1/SRC/PDGFRA/ROCK2/CYCS/RIPK1/PRKCG/E2F3/HLA-G	3.43304512729084
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	17/1163	62/9376	2.21052339611128	CRYAB/FOXO1/INSR/AKT3/ADCY1/HSPA1B/FOXO3/SOD2/HSPA1A/PRKAB2/ADCY5/ADCY6/IRS2/ADCY3/PIK3R1/PRKAG2/PRKAG1	3.59853308276726
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	27/1163	119/9376	1.82917259767191	CREB5/CREB3L2/AKT3/MAP3K5/CEBPB/BCL3/DAB2IP/LIF/TRAF5/RELA/CCL2/IRF1/PTGS2/MAPK10/CSF1/PIK3R1/NFKBIA/TNFAIP3/MAP2K3/SOCS3/MAP2K1/TRAF3/TRAF1/CXCL1/MMP14/JAG1/RIPK1	3.42537303173549
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	20/1163	80/9376	2.01547721410146	AXL/VEGFA/IL6R/BCL2/AKT3/FOXO3/PDGFA/STAT3/PDGFRB/EGFR/JAK1/PIK3R1/PDGFD/BCL2L11/FGF2/MAP2K1/PTEN/SRC/PDGFRA/PRKCG	3.4323510760432
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	33/1163	157/9376	1.69454135198339	THBS1/MFGE8/AXL/PBX1/NFATC1/SPHK1/PANX1/MAPKAPK2/DUSP16/ITGAV/CEBPB/ITGB3/CPT1C/NFATC4/ANO6/PTGS2/ODC1/DUSP8/NR1H2/ANO3/ATP11C/HIF1A/CAMK2D/MAP2K1/PTPN11/DUSP5/TMEM30A/PLA2G6/ANO4/RAB7A/ATP11B/CH25H/BSG	3.3024071125542
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	29/1163	133/9376	1.75785982583285	BCL6/FBXO32/CDKN1A/FOXO1/INSR/GADD45B/AKT3/FOXO3/SMAD3/SOD2/STAT3/HOMER1/PLK3/PRKAB2/SLC2A4/GABARAPL1/EGFR/MAPK10/IRS2/DEPP1/PIK3R1/PRKAG2/GADD45A/BCL2L11/MAP2K1/PTEN/PRKAG1/TGFBR1/BNIP3	3.31232401881098
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	48/1163	254/9376	1.52351033506882	PDE1A/AVPR1A/NGF/VEGFA/PTGER3/PLN/CACNA1H/MYLK/F2R/ITPKC/NTRK2/PLCE1/NFATC1/SPHK1/NTRK3/ADCY1/OXTR/PDGFA/FGF7/HRC/ATP2B4/EDNRA/PDGFRB/CACNA1C/EGFR/CAMK1/NFATC4/CASQ2/VEGFB/ADCY3/STIM1/GRIN2A/PPIF/PDE1B/PDGFD/PPP3CC/P2RX1/CAMK2D/FGF2/TPCN1/MCU/PDGFRA/HTR2A/SLC25A4/CAMK1D/NTRK1/PRKCG/SLC8A2	3.18289028314069
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	30/1163	140/9376	1.72755189780125	SERPINE1/ACTA2/MYLK/CCN2/SPHK1/AKT3/ADCY1/MAP1LC3A/SMAD3/NOTCH3/GNG12/MRAS/PRKAB2/ADCY5/GNB5/HDAC4/MEF2D/RRAS/ADCY6/PPARGC1A/BECN1/ADCY3/PRKAG2/MAP1LC3B/MAP2K1/PRKAG1/TGFBR1/JAG1/SLC9A1/SLC8A2	3.26370290295141
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1163	29/9376	2.77996857117443	TEAD3/TEAD4/RASSF1/WTIP/YAP1/LATS2/STK3/TEAD2/FRMD6/SAV1	3.61243295723337
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	23/1163	99/9376	1.8729687242155	PLPP1/AKT3/PDGFA/WASF3/PDGFRB/EGFR/DGKI/WASF1/MAPK10/PIK3R1/PDGFD/HIF1A/PLA2G4C/MAP2K1/PIP5K1B/CHPT1/PDGFRA/SLC44A3/SLC22A4/PIP5K1A/CHKA/PRKCG/PLA2G4A	3.28576945249943
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	24/1163	105/9376	1.84272202432134	MAP1LC3A/FOXO3/UBC/CALCOCO2/MRAS/ULK1/SMURF1/GABARAPL1/EIF2AK3/SQSTM1/RELA/RRAS/MAPK10/BECN1/RABGEF1/OPTN/MAP1LC3B/HIF1A/MITF/TFE3/SRC/RAB7A/BNIP3/PINK1	3.2676857739146
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/1163	142/9376	1.70322018093081	VEGFA/SDC4/BCL2/AKT3/MAP3K5/PDGFA/IL1R1/GPC1/ITGAV/HSP90AA1/GSTM3/MGST1/ITGB3/SQSTM1/RELA/CCL2/MAPK10/PIK3R1/ACVR1/ACTG1/HSP90AB1/GSTM5/DUSP1/SRC/GSTM4/GSTT2B/HMOX1/ASS1/BMPR1A/SDC2	3.1773506568101
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	11/1163	35/9376	2.53374278344184	PFKFB3/PFKP/HK1/HK2/ALDOA/TPI1/PMM2/PFKM/ALDOB/ALDOC/SORD	3.42069578564209
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	23/1163	101/9376	1.83588023462707	SERPINE1/VEGFA/FOXO1/BCL2/PLCE1/NFATC1/AKT3/COL4A2/COL4A1/SMAD3/STAT3/PIM1/STAT5B/RELA/COL1A1/CCL2/MAPK10/VEGFB/PIK3R1/AGT/STAT5A/TGFBR1/COL1A2	3.17813519563513
Organismal Systems	Immune system	hsa04611	Platelet activation	27/1163	126/9376	1.72755189780125	MYLK/F2R/ITGB1/AKT3/ADCY1/PTGIR/ITGB3/TLN2/RASGRP2/ADCY5/TLN1/ADCY6/COL1A1/ADCY3/STIM1/PIK3R1/P2RX1/ACTG1/PLA2G4C/GP1BB/ROCK1/SRC/ROCK2/COL1A2/PLA2G4A/PRKCI/PRKG1	3.09387646085073
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	38/1163	196/9376	1.56302314562971	CDKN1A/VEGFA/NFATC1/MYC/AKT3/MAPKAPK2/MAP1LC3A/UBC/STAT3/GNG12/ZFP36/GNB5/ANGPT2/RELA/NFATC4/HLA-F/HLA-B/PTGS2/MAPK10/BECN1/TCF7L1/JAK1/PIK3R1/NFKBIA/PPP3CC/MAP1LC3B/HIF1A/TCF7L2/FGF2/MAP2K1/TRAF3/SRC/CLEC2B/STAT2/CXCL1/CYCS/E2F3/HLA-G	2.99748851735584
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/1163	31/9376	2.60061576013092	PFKP/GPI/ALDOA/PFKM/ALDOB/PRPS2/ALDOC/PGM2/TKT/G6PD	3.35894480122689
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	11/1163	36/9376	2.46336103945734	HK1/GBE1/GPI/HK2/PYGM/UGP2/GYS1/PYGB/PGM2/GYG1/GANC	3.31019733433184
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	26/1163	122/9376	1.71811172349633	FOXO1/CREB5/INSR/PFKFB3/CREB3L2/AKT3/PFKP/FOXO3/PPP2R1B/PRKAB2/ULK1/CPT1C/SLC2A4/CAB39L/EEF2/PPARGC1A/GYS1/IRS2/PIK3R1/PRKAG2/TBC1D1/PPP2R2D/ADIPOR2/PFKM/PRKAG1/PPP2CA	3.00422024710332
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	18/1163	75/9376	1.9348581255374	PFKP/ACO1/MAT2A/PKM/GAPDH/ALDOA/TPI1/GLUL/ENO2/PFKM/ALDOB/PRPS2/ASL/ALDOC/TKT/BCAT2/ASS1/IDH3A	3.05869449055595
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	11/1163	37/9376	2.3967837140666	GFPT2/UAP1/HK1/GPI/UGDH/HK2/UGP2/PMM2/GNE/PGM2/PGM3	3.20335021121953
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	21/1163	93/9376	1.82043103209164	MYL9/ACTN1/SORBS1/INSR/VCL/SMAD3/WASF3/PTPN1/SMURF1/EGFR/WASF1/PARD3/TCF7L1/TCF7L2/ACTG1/ROCK1/ACTN4/SRC/TGFBR1/ROCK2/CTNNA1	2.99201634724476
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	17/1163	70/9376	1.95789215084142	ACSL4/AKT3/STAT3/PRKAB2/CPT1C/SLC2A4/RELA/PPARGC1A/MAPK10/IRS2/PRKAG2/NFKBIA/ADIPOR2/SOCS3/PTPN11/PRKAG1/ACSL1	3.0269740279458
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	31/1163	155/9376	1.61238177128117	THBS1/THBS2/C1R/ITGA5/ITGB1/TUBB3/DYNC1I1/THBS3/COMP/TUBB6/ITGAV/ITGB3/HLA-DRB1/DYNC2H1/HLA-F/HLA-B/TUBA1C/THBS4/MRC2/ACTG1/EEA1/STX12/DYNC1LI1/PLA2R1/TUBA4A/RAB7A/TUBB4B/STX18/DYNC1H1/DYNC1LI2/HLA-G	2.89283509018892
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	15/1163	59/9376	2.04963784484894	PTGER3/INSR/AKT3/ADCY1/ADCY5/PNPLA2/ADCY6/PTGS2/IRS2/ADCY3/PIK3R1/NPPA/MGLL/NPY1R/PRKG1	3.04335085417077
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/1163	59/9376	2.04963784484894	CDKN1A/GADD45B/MYC/AKT3/FOXO3/EGFR/TCF7L1/PIK3R1/GADD45A/TCF7L2/MAP2K1/ELK1/PTEN/MLH1/CTNNA1	3.04335085417077
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	21/1163	94/9376	1.8010647445162	FOSL1/CSF3/HSP90AA1/CEBPB/JUND/MAPK6/TRAF5/RELA/CCL2/PTGS2/MAPK10/NFKBIA/TNFAIP3/IL17D/HSP90AB1/TRAF3/IL17RE/TRAF3IP2/IL17B/CXCL1/FOSB	2.9372123623354
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	11/1163	38/9376	2.33371045843327	GFPT2/UAP1/HK1/GPI/UGDH/HK2/UGP2/PMM2/GNE/PGM2/PGM3	3.09992369970638
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	20/1163	89/9376	1.81166491155188	TUBB3/TUBB6/ADCY1/PDGFA/PDGFRB/ADCY5/EGFR/ADCY6/ADCY3/TUBA1C/PDGFD/MAP2K1/SRC/PDGFRA/HTR2A/TUBA4A/TUBB4B/CSNK1D/PRKCG/PRKG1	2.89506711633499
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	33/1163	170/9376	1.56495877800819	MYL9/ACTN1/MYH11/ITGB1/MYH9/MAP3K5/PPP2R1B/PRKAB2/MICALL2/HSPA4/YBX3/TJP2/DLG2/PARD3/MAPK10/TUBA1C/PRKAG2/RAB13/CTTN/PPP2R2D/ARHGAP17/ACTG1/MYL6B/ROCK1/ACTN4/PRKAG1/SRC/SYNPO/PPP2CA/TUBA4A/ROCK2/CLDN12/PRKCI	2.79724380315963
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	45/1163	250/9376	1.45114359415305	ASAP1/ASAP2/WIPF3/EHD2/HSPA1B/ARFGAP3/SMAD3/HSPA1A/SPART/CBLB/AMPH/SMURF1/KIF5C/RAB31/EGFR/EHD1/HLA-F/CLTCL1/CLTB/HLA-B/PARD3/RAB11FIP3/RAB11FIP5/AP2A1/EPN2/IGF2R/EEA1/LDLR/GRK5/PIP5K1B/SRC/TGFBR1/PDGFRA/AP2B1/AGAP1/ZFYVE27/RAB7A/PIP5K1A/SH3GL1/ARF4/PRKCI/ZFYVE9/GRK4/HLA-G/ACAP1	2.72062792494509
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	41/1163	224/9376	1.47561724603857	FOSL1/CDKN1A/CREB5/NFATC1/MYC/CREB3L2/AKT3/ADCY1/RELB/IL1R1/SMAD3/CDKN2C/CRTC3/TLN2/ZFP36/ADCY5/TLN1/HLA-DRB1/STAT5B/RELA/NFATC4/ADCY6/HLA-F/HLA-B/MAPK10/ADCY3/JAK1/PIK3R1/NFKBIA/PPP3CC/SRF/MAP2K1/STAT5A/ELK1/PTEN/TGFBR1/SLC25A4/CRTC1/IL15RA/E2F3/HLA-G	2.71111650835805
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	13/1163	50/9376	2.09609630266552	CKB/MAOB/MAOA/SAT2/CKMT2/P4HA1/ODC1/ALDH1B1/OAT/ALDH2/P4HA2/P4HA3/ALDH3A2	2.9242237062888
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	22/1163	103/9376	1.72196111496047	COL18A1/COL12A1/ACE2/COL6A3/COL6A2/COL4A2/COL4A1/ATP1A1/COL8A1/COL5A2/ELN/COL5A1/COL1A1/SLC1A5/SLC38A2/COL6A1/ATP1B2/SLC3A2/COL16A1/COL7A1/COL1A2/SLC8A2	2.77234244148813
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	33/1163	174/9376	1.52898271414594	CRYAB/DNAJB1/PPP1R15A/HSPH1/CAPN2/BCL2/ERN1/DDIT3/HSPA1B/BAG2/MAP3K5/HSP90AA1/HSPA1A/SSR3/SEC24D/EIF2AK3/MAPK10/OS9/STUB1/HSPA4L/RNF185/UBE2G2/UBE2G1/HSP90AB1/SELENOS/SEL1L2/NPLOC4/SEC13/UBQLN1/BAG1/SIL1/SEC63/SEC24A	2.65032769257243
Cellular Processes	Cell motility	hsa04814	Motor proteins	36/1163	194/9376	1.49602432386913	ACTG2/ACTA2/TPM1/MYL9/TPM2/MYH11/TPM4/MYH9/MYO1D/TUBB3/DYNC1I1/TUBB6/MYO9B/KIF5C/MYO1E/KIF9/DCTN2/DYNC2H1/KLC1/TUBG2/TUBA1C/HOOK3/DYNLT3/ACTG1/MYL6B/KIF22/KIF21A/DYNC1LI1/DYNLRB2/DNALI1/DYNC2LI1/TUBA4A/TUBB4B/MYO1C/DYNC1H1/DYNC1LI2	2.62699822107845
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	26/1163	130/9376	1.61238177128117	ACTA2/VEGFA/CREB5/CREB3L2/AKT3/COL4A2/ADCY1/RXFP1/COL4A1/GNG12/ADCY5/GNB5/EGFR/GNAO1/RELA/ADCY6/COL1A1/MAPK10/VEGFB/ADCY3/PIK3R1/NFKBIA/MAP2K1/SRC/TGFBR1/COL1A2	2.64570592771642
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	15/1163	63/9376	1.91950210866806	PLOD2/AASS/PLOD1/DLST/EZH1/ALDH1B1/ALDH2/ACAT1/EZH2/PHYKPL/PRDM16/ALDH3A2/DOT1L/ACAT2/KMT2A	2.75551504710679
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	22/1163	105/9376	1.68916185562789	NFATC1/AKT3/MAPKAPK2/RELB/BCL3/PLK3/CBLB/MRAS/EGR3/RELA/NFATC4/RRAS/IRF1/PTGS2/MAPK10/PIK3R1/NFKBIA/PPP3CC/IL17D/PTPN11/SRC/STAT2	2.67225054830317
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	31/1163	163/9376	1.5332464696232	CDKN1A/CREB5/BCL2/NFATC1/MYC/CREB3L2/AKT3/SMAD3/STAT3/HSPG2/EGR3/STAT5B/RELA/NFATC4/MAPK10/JAK1/PIK3R1/YWHAQ/NFKBIA/MAP2K3/STAT6/MAP2K1/STAT5A/ELK1/TRAF3/SRC/TGFBR1/STAT2/CYCS/PRKCG/E2F3	2.58431732846493
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	22/1163	106/9376	1.67322636642385	AR/CDKN1A/FOXO1/CREB5/BCL2/CREB3L2/AKT3/PDGFA/HSP90AA1/PDGFRB/EGFR/RELA/TCF7L1/PIK3R1/NFKBIA/PDGFD/TCF7L2/HSP90AB1/MAP2K1/PTEN/PDGFRA/E2F3	2.6230028723919
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	28/1163	144/9376	1.56759338874558	FOXO1/ADH1B/AKT3/FOXO3/MAP3K5/LPIN1/PRKAB2/CPT1C/RELA/PPARGC1A/ADH5/MAPK10/TCF7L1/PRKAG2/NFKBIA/LPIN2/ALDH1B1/TCF7L2/ADIPOR2/MAP2K3/ALDH2/TRAF3/PRKAG1/CXCL1/LBP/ALDH3A2/RIPK1/LPIN3	2.58282665967853
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	27/1163	138/9376	1.57732999364462	RHOQ/SORBS1/FOXO1/INSR/AKT3/PPP1R3B/HK1/PTPN1/CBLB/PRKAB2/SLC2A4/HK2/PYGM/PPARGC1A/GYS1/MAPK10/IRS2/PIK3R1/PRKAG2/PYGB/SOCS3/MAP2K1/ELK1/TRIP10/SOCS2/PRKAG1/PRKCI	2.5709833795242
NA	NA	hsa04517	IgSF CAM signaling	51/1163	299/9376	1.37510819958762	MYL9/ACTN1/SORBS1/MYH11/FOXO1/NLGN1/SLIT3/MYLK/ITGA5/ITGB1/MYH9/NFASC/TUBB3/VCL/PPFIA2/AKT3/TUBB6/NTRK3/TRIO/ITGB3/KCNQ3/MAP2/SLITRK4/PTPRS/TJP2/PLXNA4/PARD3/MAPK10/TUBA1C/ANK2/PIK3R1/SLITRK2/MAGI2/IL1RAP/NLGN2/ACTG1/MYL6B/MAP2K1/CNTNAP1/PTPN11/NTN1/ACTN4/SRC/PVR/TUBA4A/CADM4/TUBB4B/KIRREL1/PRKCG/PRKCI/PPFIA1	2.48053619345315
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	34/1163	184/9376	1.48970054955325	TRPC4/MYL9/EPHB6/ENAH/SLIT3/ITGB1/SEMA5A/NTN4/CXCL12/BOC/ABLIM2/RGMA/SEMA4A/CFL2/NFATC4/PLXNA4/RRAS/PARD3/PIK3R1/SSH1/PPP3CC/NEO1/CAMK2D/ROCK1/PTPN11/NTN1/SRC/SEMA4B/ROCK2/WNT5B/SEMA5B/SEMA3C/PLXNB1/WNT5A	2.5244052761798
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	33/1163	178/9376	1.4946235520303	FOSL1/TLE2/DAAM1/DKK1/NFATC1/MYC/DAAM2/CCN4/SMAD3/CTBP2/APCDD1/TLE1/NFATC4/ROR2/MAPK10/TCF7L1/CELSR2/WNT9A/FZD8/PPP3CC/TCF7L2/CAMK2D/FZD10/MCC/SFRP4/TLE6/CACYBP/ROCK2/WNT5B/PRICKLE2/PRKCG/CSNK1A1/WNT5A	2.50704814749412
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	11/1163	42/9376	2.11145231953486	MAOB/DLST/MAOA/AOX1/ALDH1B1/CYP1B1/ALDH2/ACAT1/KYAT1/ALDH3A2/ACAT2	2.71647784644435
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	16/1163	71/9376	1.81676819299287	ESR1/AKT3/FOXO3/STAT3/STAT5B/RELA/IRF1/MAPK10/PIK3R1/SOCS5/PRLR/SOCS3/MAP2K1/STAT5A/SOCS2/SRC	2.59952732364805
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	44/1163	253/9376	1.40207110546189	MYL9/ACTN1/FOXO1/CD44/ITGA5/ITGB1/CAPN2/BCL2/PLCE1/VCL/AKT3/MAP1LC3A/FOXO3/UBC/CALCOCO2/IL1R1/HK1/TLN2/TLN1/HK2/TRAF5/EGFR/SQSTM1/TNIP1/RELA/WASF1/MAPK10/BECN1/CAPNS1/PIK3R1/CAST/NFKBIA/CTTN/MAP1LC3B/ACTG1/RRAGC/ROCK1/ACTN4/SRC/ROCK2/NOD1/CYCS/RIPK1/BNIP3	2.43960138523801
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	40/1163	226/9376	1.42688652325767	MYL9/PTGER3/PLN/F2R/CREB5/SSTR2/PLCE1/NFATC1/CREB3L2/AKT3/PDE10A/ADCY1/OXTR/ATP1A1/ATP2B4/GABBR1/EDNRA/CACNA1C/ADCY5/FXYD1/RELA/RRAS/ADCY6/GRIA1/MAPK10/ADCY3/PIK3R1/GRIN2A/NPPA/ATP1B2/GRIA3/NFKBIA/CAMK2D/NPY1R/ROCK1/MAP2K1/ADCYAP1R1/ROCK2/SLC9A1/CRH	2.44444742598566
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/1163	32/9376	2.26741186586414	PFKP/HK1/HK2/UGP2/B4GALT1/PFKM/B4GALT2/PGM2/GANC	2.70240805811919
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	22/1163	109/9376	1.62717426459568	IL6R/RORA/NFATC1/IL1R1/SMAD3/STAT3/HSP90AA1/RARA/HLA-DRB1/IL4R/STAT5B/RELA/MAPK10/JAK1/NFKBIA/PPP3CC/HIF1A/IL1RAP/HSP90AB1/STAT6/STAT5A/TGFBR1	2.47831485961914
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	24/1163	122/9376	1.58594928322738	RCAN2/ESR1/FOXO1/PLN/PLCE1/MYC/AKT3/PFKP/ATP1A1/NOTCH3/ITGAV/ITGB3/PIK3R1/DIO2/ATP1B2/HIF1A/MED13L/ACTG1/PFKM/MAP2K1/SRC/SIN3A/SLC9A1/PRKCG	2.45131870550276
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	20/1163	97/9376	1.66224924874347	CACNA1H/PER1/ADCY1/PER2/CACNA1C/GNG12/RASD1/ADCY5/GNB5/GNAO1/ADCY6/GRIA1/ADCY3/GRIN2A/GRIA3/CAMK2D/ADCYAP1R1/NOS1AP/PRKCG/PRKG1	2.4670692388207
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	31/1163	168/9376	1.48761413421775	CDKN1A/IL6R/OSMR/FHL1/BCL2/MYC/AKT3/CSF3/PDGFA/STAT3/CLCF1/PDGFRB/PIM1/MCL1/LIF/EGFR/IL4R/STAT5B/AOX1/JAK1/PIK3R1/SOCS5/PRLR/STAT6/SOCS3/STAT5A/PTPN11/SOCS2/PDGFRA/STAT2/IL15RA	2.39978787932972
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	23/1163	116/9376	1.5984819284253	PFKP/ACO1/HK1/PKM/GPI/GAPDH/HK2/ME3/DLST/ALDOA/ADH5/TPI1/ENO2/PFKM/ALDOB/ACAT1/GLUD1/PRPS2/ALDOC/TKT/IDH3A/G6PD/ACAT2	2.44061415944534
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	29/1163	155/9376	1.50835714087593	NR4A1/CDKN1A/PBX1/CACNA1H/CREB5/CREB3L2/ADCY1/CACNA1C/CDKN2C/RASD1/ADCY5/EGFR/ADCY6/ADCY3/TCF7L1/PDE8A/WNT9A/FZD8/AGT/TCF7L2/CAMK2D/FZD10/MAP2K1/LDLR/WNT5B/CRH/E2F3/KMT2A/WNT5A	2.40143231631041
Human Diseases	Cancer: specific types	hsa05218	Melanoma	16/1163	73/9376	1.76699372195197	CDKN1A/GADD45B/AKT3/PDGFA/FGF7/PDGFRB/EGFR/PIK3R1/GADD45A/PDGFD/MITF/FGF2/MAP2K1/PTEN/PDGFRA/E2F3	2.47551927885124
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	20/1163	98/9376	1.64528752171548	NR4A1/CACNA1H/CREB5/CREB3L2/ADCY1/ATP1A1/ATP2B4/CACNA1C/ADCY5/CAMK1/ADCY6/PRKD1/ADCY3/NPPA/ATP1B2/AGT/CAMK2D/LDLR/CAMK1D/PRKCG	2.41637150065041
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1163	44/9376	2.01547721410146	CREB5/DYNC1I1/CREB3L2/DCTN2/DYNC2H1/ADCY6/ADCY3/DYNC1LI1/DYNC2LI1/DYNC1H1/DYNC1LI2	2.54058506199803
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	38/1163	217/9376	1.41176284121393	AR/BCL6/ESR1/VEGFA/EPHX1/CREB5/BCL2/MYC/CREB3L2/AKT3/ADCY1/FGF7/PGR/STAT3/HSP90AA1/GSTM3/CACNA1C/MGST1/ADCY5/EGFR/STAT5B/RELA/ADCY6/ADCY3/PIK3R1/HSP90AB1/CYP1B1/FGF2/MAP2K1/STAT5A/GSTM5/SRC/UGT2B7/GSTM4/GSTT2B/JAG1/PRKCG/VDR	2.30928520685158
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1163	170/9376	1.47011279146224	CDKN1A/GADD45B/MYC/AKT3/SMARCD3/SMAD3/GSTM3/MGST1/TXNRD1/EGFR/TCF7L1/PIK3R1/WNT9A/GADD45A/FZD8/TCF7L2/ACTG1/FZD10/MAP2K1/ELK1/GSTM5/PTEN/TGFBR1/GSTM4/GSTT2B/HMOX1/WNT5B/PRKCG/E2F3/CSNK1A1/WNT5A	2.32763901348704
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	41/1163	238/9376	1.38881623156571	NGF/VEGFA/RASAL2/NTRK2/PLCE1/INSR/AKT3/PDGFA/FGF7/ABL2/PDGFRB/GNG12/MRAS/RASGRP2/GNB5/ANGPT2/EGFR/ANGPT4/RASSF1/RELA/RRAS/SYNGAP1/MAPK10/VEGFB/CSF1/PIK3R1/GRIN2A/PDGFD/FLT3LG/PLA2G4C/FGF2/MAP2K1/ELK1/PTPN11/PDGFRA/PLA2G6/RASA3/NTRK1/PRKCG/PLA2G4A/NTF3	2.28629292576791
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	14/1163	62/9376	1.82043103209164	TLE2/NOTCH3/HEYL/CTBP2/TLE1/SPEN/NCOR2/DTX3/HES1/NUMBL/TLE6/SNW1/HEY2/JAG1	2.43890223071679
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	36/1163	205/9376	1.4157498479542	CDKN1A/CD44/BCL2/GADD45B/MYC/AKT3/RELB/STAT3/VIM/TRAF5/HLA-DRB1/PSMD8/RELA/NCOR2/HLA-F/HLA-B/MAPK10/HES1/JAK1/PIK3R1/GADD45A/PSMD2/NFKBIA/TNFAIP3/MAP2K3/SAP30/BCL2L11/TRAF3/SIN3A/SNW1/STAT2/CYCS/RIPK1/PSMC3/E2F3/HLA-G	2.26477606721268
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	18/1163	87/9376	1.66798114270466	CDKN1A/BCL2/GADD45B/MYC/AKT3/SMAD3/EGFR/MAPK10/TCF7L1/PIK3R1/GADD45A/BBC3/TCF7L2/BCL2L11/MAP2K1/TGFBR1/MLH1/CYCS	2.35539599037953
Human Diseases	Cancer: specific types	hsa05214	Glioma	16/1163	76/9376	1.69724396976965	CDKN1A/GADD45B/AKT3/PDGFA/PDGFRB/EGFR/CAMK1/PIK3R1/GADD45A/CAMK2D/MAP2K1/PTEN/PDGFRA/CAMK1D/PRKCG/E2F3	2.29654348347712
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	15/1163	70/9376	1.72755189780125	DMD/SGCD/SSPN/SNTA1/ABL2/HLA-DRB1/DTNA/HLA-F/HLA-B/ACTG1/SNTB2/EIF4G1/CYCS/SGCA/HLA-G	2.29909045260739
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	28/1163	154/9376	1.46580161025561	TPM1/CACNB2/TPM2/TPM4/PLN/CREB5/BCL2/CREB3L2/AKT3/ADCY1/ATP1A1/ATP2B4/PPP2R1B/CACNA1C/ADCY5/ADCY6/ADCY3/SCN4B/ATP1B2/SCN7A/AGT/PPP2R2D/CAMK2D/PPP2CA/CACNA2D1/SLC9A1/CACNA2D3/SLC8A2	2.19317542645945
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	27/1163	148/9376	1.47075364272269	CDKN1A/ESR1/GADD45B/MYC/AKT3/FGF7/PGR/NOTCH3/HEYL/EGFR/HES1/TCF7L1/PIK3R1/WNT9A/GADD45A/FZD8/TCF7L2/FZD10/FGF2/MAP2K1/PTEN/WNT5B/HEY2/JAG1/E2F3/CSNK1A1/WNT5A	2.17217763694879
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	16/1163	77/9376	1.67520184029212	CDKN1A/VEGFA/GADD45B/AKT3/SMAD3/STAT3/EGFR/RELA/MAPK10/JAK1/PIK3R1/GADD45A/MAP2K1/TGFBR1/ARHGEF6/E2F3	2.2386460862422
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	16/1163	77/9376	1.67520184029212	CDKN1A/GADD45B/MYC/AKT3/SMAD3/CTBP2/STAT5B/RELA/PIK3R1/GADD45A/NFKBIA/MAP2K1/STAT5A/PTPN11/TGFBR1/E2F3	2.2386460862422
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1163	41/9376	1.96631923326972	THBS1/CDKN1A/VEGFA/MYC/EGFR/RASSF1/DAPK3/MAP2K1/SRC/E2F3	2.33335047090441
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/1163	47/9376	1.8868297323503	ADH1B/LDHA/PKM/ME3/ADH5/ALDH1B1/ALDH2/ACAT1/ALDH3A2/ACAT2/ACYP2	2.29348662437024
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	11/1163	47/9376	1.8868297323503	INSR/HK1/CACNA1C/PKM/SLC2A4/HK2/MAPK10/IRS2/PIK3R1/SOCS3/SOCS2	2.29348662437024
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	12/1163	53/9376	1.82533785428057	ESR1/ATP1A1/ATP2B4/ADCY6/CLTCL1/CLTB/AP2A1/ATP1B2/AP2B1/PRKCG/VDR/SLC8A2	2.26733891184501
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	22/1163	116/9376	1.52898271414594	ADCY1/HOMER1/CACNA1C/GNG12/ADCY5/GNB5/GNAO1/GLS/ADCY6/GRIA1/ADCY3/SLC38A2/GRIK2/GRIN2A/GRIA3/GLUL/PPP3CC/PLA2G4C/GRIK5/NCDN/PRKCG/PLA2G4A	2.15719579978521
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	13/1163	60/9376	1.74674691888793	HSPB1/VEGFA/SPHK1/AKT3/MAPKAPK2/PTGS2/PIK3R1/PPP3CC/PLA2G4C/MAP2K1/SRC/PRKCG/PLA2G4A	2.18352872096682
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	15/1163	73/9376	1.65655661432997	CDKN1A/GADD45B/AKT3/FOXO3/STAT3/KIF5C/EGFR/RASSF1/STAT5B/PIK3R1/GADD45A/MAP2K1/STAT5A/PRKCG/E2F3	2.11907674067367
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	9/1163	37/9376	1.96100485696358	CDKN1A/GADD45B/MYC/TCF7L1/CCDC6/GADD45A/TCF7L2/MAP2K1/NTRK1	2.20394545020483
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	10/1163	43/9376	1.87486252474555	ADH1B/ACSL4/CPT1C/ADH5/ALDH1B1/ALDH2/ACAT1/ACSL1/ALDH3A2/ACAT2	2.16365490055902
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	14/1163	68/9376	1.65980476455414	ZBTB16/MYC/AKT3/PER2/STAT3/PIM1/RARA/STAT5B/RELA/TCF7L1/PIK3R1/TCF7L2/MAP2K1/STAT5A	2.05478459228478
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	15/1163	75/9376	1.61238177128117	CDKN1A/BCL2/AKT3/MAP3K5/GSTM3/MGST1/REV3L/ERCC1/PIK3R1/BBC3/GSTM5/GSTM4/GSTT2B/MLH1/CYCS	2.00360749804454
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	14/1163	69/9376	1.63574962303887	MAOB/CREB5/CREB3L2/CACNA1C/ADCY5/ARC/MAOA/GRIA1/GRIN2A/GRIA3/PPP3CC/CAMK2D/PRKCG/FOSB	1.99448320644383
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	23/1163	128/9376	1.44862424763543	PDE1A/PDE10A/ADCY1/ADA/NME1/ADCY5/ADCY6/ENTPD2/ADCY3/AK1/PDE8A/ENTPD4/PDE1B/GMPS/IMPDH2/PDE7B/PRPS2/GART/PRUNE1/PAICS/PGM2/NME4/PDE5A	1.92304037024019
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	13/1163	63/9376	1.66356849417898	CDKN1A/GADD45B/BMP2/GLI2/TCF7L1/WNT9A/GADD45A/FZD8/TCF7L2/FZD10/PTCH2/WNT5B/WNT5A	1.98854679424805
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	21/1163	115/9376	1.47217466073498	CDKN1A/CREB5/BCL2/STK39/AKAP13/CREB3L2/ADCY1/JUND/ADCY5/MEF2D/EGFR/ADCY6/ADCY3/MAP2K1/MMP24/MMP14/PRKCG/PTHLH/MMP17/OXSR1/VDR	1.91711091205931
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	25/1163	142/9376	1.41935015077568	FOSL1/FOSL2/NFATC1/AKT3/RELB/IL1R1/CTSK/JUND/ITGB3/FHL2/SQSTM1/RELA/MAPK10/CSF1/JAK1/PIK3R1/NFKBIA/PPP3CC/MITF/SOCS3/MAP2K1/TNFRSF11B/TGFBR1/STAT2/FOSB	1.89474436759887
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	26/1163	149/9376	1.4067760420574	AVPR1A/F2R/PLPP1/INSR/SPHK1/AKT3/ADCY1/PDGFA/PDGFRB/MRAS/ADCY5/EGFR/RRAS/ADCY6/DGKI/ADCY3/PIK3R1/PDGFD/AGT/PLA2G4C/MAP2K1/PTPN11/PIP5K1B/PDGFRA/PIP5K1A/PLA2G4A	1.88340112004309
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	17/1163	89/9376	1.53991517481909	ADCY1/GABBR1/CACNA1C/GNG12/ADCY5/GABARAPL1/GNB5/GNAO1/GLS/ADCY6/ADCY3/SLC38A2/SLC6A1/GLUL/SRC/SLC38A5/PRKCG	1.92578322160119
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	27/1163	158/9376	1.37766796913264	SLC7A5/RNF152/INSR/AKT3/LPIN1/DDIT4/ULK1/CAB39L/CLIP1/PIK3R1/WNT9A/GRB10/SLC3A2/FLCN/FZD8/SESN2/LPIN2/FZD10/RRAGC/MAP2K1/FNIP1/PTEN/SEC13/WNT5B/PRKCG/LPIN3/WNT5A	1.80154422838754
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	13/1163	65/9376	1.61238177128117	NR4A1/PBX1/CACNA1H/CREB5/CREB3L2/ADCY1/CACNA1C/ADCY5/ADCY6/ADCY3/PDE8A/AGT/LDLR	1.86425515968318
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	18/1163	98/9376	1.48075876954393	ASAP1/ASAP2/PLPP1/GSN/SPHK1/AKT3/WASF3/AMPH/CFL2/WASF1/PIK3R1/PLA2G4C/MAP2K1/PIP5K1B/PLA2G6/PIP5K1A/PRKCG/PLA2G4A	1.80027003517035
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	24/1163	139/9376	1.39198426297655	FKBP5/ESR1/GREB1/CREB5/BCL2/CREB3L2/AKT3/ADCY1/HSPA1B/PGR/GABBR1/HSP90AA1/HSPA1A/RARA/ADCY5/EGFR/GNAO1/ADCY6/ADCY3/PIK3R1/FKBP4/HSP90AB1/MAP2K1/SRC	1.75200420497652
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	18/1163	99/9376	1.46580161025561	NGF/ADCY1/IL1R1/ADCY5/ADCY6/MAPK10/ADCY3/PIK3R1/IL1RAP/CAMK2D/PLA2G4C/MAP2K3/SRC/HTR2A/PLA2G6/NTRK1/PRKCG/PLA2G4A	1.75323199955226
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	19/1163	107/9376	1.43155390908141	FOXO1/CREB5/CREB3L2/AKT3/PFKP/LDHA/PKM/PRKAB2/CPT1C/SIK2/PYGM/PPARGC1A/GYS1/PRKAG2/PPP3CC/PYGB/CAMK2D/PFKM/PRKAG1	1.68941010208141
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	10/1163	48/9376	1.67956434508455	AOX1/OXCT1/ALDH1B1/ALDH2/ACAT1/AACS/OXCT2/ALDH3A2/BCAT2/ACAT2	1.77615768254571
NA	NA	hsa04081	Hormone signaling	35/1163	219/9376	1.28843292225664	ADRA2C/RAMP1/AVPR1A/ESR1/SSTR2/HEPH/INSR/ADCY1/OXTR/STAT3/ITGAV/ITGB3/GNG12/ADCY5/ADRA2A/GNB5/GNAO1/STAT5B/ADCY6/IRS2/ADCY3/PIK3R1/DIO2/NPPA/AGT/ACVR1/PRLR/ADIPOR2/STAT5A/SRC/ADRA2B/BMPR1A/CRH/PTHLH/PRKG1	1.62523012789183
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	9/1163	42/9376	1.72755189780125	SLC39A14/ACSL4/MAP1LC3A/TF/SAT2/SLC3A2/MAP1LC3B/ACSL1/HMOX1	1.77819468975759
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	21/1163	122/9376	1.38770562282396	CREB5/SSTR2/CREB3L2/AKT3/ADCY1/STAT3/CACNA1C/ADCY5/STAT5B/ADCY6/MAPK10/IRS2/ADCY3/PIK3R1/MAP2K3/SOCS3/MAP2K1/STAT5A/SOCS2/IGFBP3/PRKCG	1.62196639310191
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	47/1163	308/9376	1.23022635146453	GPX3/MT-ATP8/TGM2/CREB5/TUBB3/CREB3L2/ERN1/TUBB6/COX7A1/MAP3K5/SOD2/ULK1/ATG101/KIF5C/PSMD8/IFT57/DCTN2/NDUFS2/KLC1/TAF4B/PPARGC1A/GRIA1/CLTCL1/CLTB/MAPK10/BECN1/TUBA1C/AP2A1/GRIA3/PPIF/PSMD2/RB1CC1/BBC3/POLR2A/HIP1/SIN3A/DNALI1/AP2B1/SLC25A4/TUBA4A/NDUFA10/TUBB4B/POLR2H/NDUFB1/CYCS/PSMC3/MAP3K10	1.54596343461761
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	32/1163	200/9376	1.28990541702494	MYH11/F2R/ITGB1/MYH9/MYO1D/TUBB3/TUBB6/WIPF3/IL1R1/WASF3/SEC24D/GAPDH/MYO1E/RELA/WASF1/MAPK10/TUBA1C/CYFIP2/NFKBIA/CTTN/ACTG1/ROCK1/PTPN11/SRC/TUBA4A/ROCK2/TUBB4B/MYO1C/CYCS/RIPK1/CLDN12/SEC24A	1.55944193968386
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	24/1163	144/9376	1.34365147606764	RORA/AKT3/ERN1/MAP3K5/ULK1/ATG101/PSMD8/GRIA1/MAPK10/BECN1/AFG3L2/PIK3R1/GRIN2A/GRIA3/PPIF/PSMD2/RB1CC1/RELN/MCU/SLC25A4/KCND3/CYCS/PSMC3/PRKCG	1.56378176988111
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1163	69/9376	1.51891036425038	PDE1A/KCNMA1/EDNRA/REN/CACNA1C/ADCY5/ADCY6/NPPA/PDE1B/PPP3CC/AGT/AQP1/ADCYAP1R1	1.62793333985784
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/1163	103/9376	1.40887727587675	LAMA3/ACTN1/LAMB1/HSPB1/VCL/COL4A2/ADCY1/IL1R1/COL4A1/RELA/COL1A1/PIK3R1/ACTN4/LAMB3/CXCL1/RAB7A/COL1A2/PRKCG	1.57009539957734
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	18/1163	104/9376	1.39533037899332	PLPP1/LPIN1/SGMS2/DGKI/GPAT2/ACHE/LPIN2/PLA2G4C/MBOAT7/PEMT/SAMD8/CHPT1/PLA2G6/CHKA/LPIN3/PLA2G4A/CDIPT/PNPLA7	1.52550884874776
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	41/1163	268/9376	1.23335172803224	SLC39A14/MAOB/MT-ATP8/TUBB3/ERN1/TUBB6/DDIT3/COX7A1/MAP3K5/UBC/UCHL1/KIF5C/ADCY5/MAOA/EIF2AK3/PSMD8/NDUFS2/KLC1/MAPK10/TUBA1C/PPIF/PSMD2/UBE2G2/UBE2G1/CAMK2D/SLC39A10/DUSP1/DAXX/MCU/SLC25A4/TUBA4A/NDUFA10/SLC39A11/TUBB4B/UBE2L6/NDUFB1/CYCS/SLC39A7/PSMC3/SEPTIN5/PINK1	1.4584498209611
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	21/1163	125/9376	1.35440068787618	CERS6/BCL2/SPHK1/AKT3/S1PR3/MAP3K5/PPP2R1B/SGMS2/CERS4/RELA/MAPK10/PIK3R1/PPP2R2D/ROCK1/MAP2K1/CERS5/PTEN/SPTSSA/PPP2CA/ROCK2/PRKCG	1.5009969381575
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1163	20/9376	2.01547721410146	UAP1/CYB5R3/UGDH/UGP2/GNE	1.71066377278037
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	7/1163	32/9376	1.76354256233878	BCL2/MAPK10/BECN1/BBC3/BCL2L11/SEPTIN4/CYCS	1.62804501737438
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1163	91/9376	1.41747848024718	PDE1A/PDE10A/ADCY1/GABBR1/GNG12/ADCY5/GNB5/GNAO1/ADCY6/ADCY3/PDE8A/PDE1B/PDE7B/GRK5/PRKCG/GRK4	1.50587325503956
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	18/1163	105/9376	1.382041518241	CCL21/BCL2/GADD45B/RELB/IL1R1/CXCL12/TRAF5/RELA/PTGS2/GADD45A/CCL19/NFKBIA/TNFAIP3/TRAF3/TRAF1/CXCL1/LBP/RIPK1	1.48138009708031
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/1163	112/9376	1.36764525242599	LAMA3/LAMB1/ITGB1/BCL2/AKT3/HSPA1B/STAT3/HSPA1A/HLA-DRB1/GNAO1/RELA/MAPK10/JAK1/PPIF/NFKBIA/MAP2K3/LDLR/LAMB3/CYCS	1.47286616097528
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	22/1163	133/9376	1.33354883339044	MAOB/CREB5/CREB3L2/AKT3/PPP2R1B/CACNA1C/GNG12/KIF5C/ADCY5/GNB5/MAOA/GNAO1/GRIA1/MAPK10/GRIN2A/GRIA3/PPP3CC/PPP2R2D/CAMK2D/PPP2CA/LRTOMT/PRKCG	1.45781815399885
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	17/1163	99/9376	1.38436818746363	CDKN1A/ESR1/BCL2/AKT3/ADCY1/NOTCH3/CDKN2C/ADCY5/EGFR/ADCY6/MAPK10/ADCY3/PIK3R1/MAP2K1/SRC/JAG1/E2F3	1.44672450896282
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/1163	52/9376	1.55036708777036	INSR/ADCY1/ADCY5/ADCY6/PTGS2/ADCY3/CYP1B1/PLA2G4C/LDLR/PLA2G4A	1.4975370589925
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/1163	86/9376	1.40614689355916	CDKN1A/MYC/AKT3/ABL2/CBLB/EGFR/STAT5B/MAPK10/PIK3R1/CAMK2D/MAP2K1/STAT5A/ELK1/SRC/PRKCG	1.42380032793389
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1163	21/9376	1.91950210866806	DPYD/ALDH1B1/ALDH2/ALDH3A2/BCAT2	1.58732210815813
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	30/1163	193/9376	1.2531464543636	CCL21/CCL14/AKT3/ADCY1/FOXO3/CXCL12/STAT3/CCL26/GNG12/RASGRP2/ADCY5/GNB5/CXCL13/STAT5B/RELA/ADCY6/CCL2/PARD3/ADCY3/PIK3R1/CCL19/NFKBIA/ROCK1/MAP2K1/GRK5/SRC/STAT2/CXCL1/ROCK2/GRK4	1.33715821068853
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	24/1163	150/9376	1.28990541702494	CDKN1A/BCL2/GADD45B/MYC/AKT3/FGF7/SMAD3/EGFR/TCF7L1/PIK3R1/WNT9A/GADD45A/FZD8/TCF7L2/FZD10/FGF2/MAP2K1/TGFBR1/WNT5B/MLH1/E2F3/CTNNA1/CSNK1A1/WNT5A	1.34685182465383
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/1163	101/9376	1.35695495602871	CREB3L2/ADCY1/ADCY5/GNAO1/ADCY6/ADCY3/TCF7L1/WNT9A/FZD8/TCF7L2/CAMK2D/MITF/FZD10/MAP2K1/WNT5B/PRKCG/WNT5A	1.35719336576652
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1163	60/9376	1.47801662367441	PPP2R1B/GNAO1/GRIA1/GRIA3/PLA2G4C/MAP2K1/PPP2CA/CRH/PRKCG/PLA2G4A/PRKG1	1.39774668029034
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	33/1163	216/9376	1.23168051972867	BCL2/NFATC1/AKT3/ERN1/DDIT3/HSPA1B/MAP3K5/HSPD1/SOD2/STAT3/HSP90AA1/HSPA1A/APOA1/HSPA4/EIF2AK3/RELA/APOB/CCL2/MAPK10/PIK3R1/NFKBIA/PPP3CC/CAMK2D/HSP90AB1/MAP2K3/LDLR/TRAF3/SRC/CXCL1/ROCK2/LBP/CYCS/POU2F1	1.29626334855521
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/1163	22/9376	1.83225201281951	MAOB/MAOA/ALDH1B1/ALDH2/ALDH3A2	1.47059165078392
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	68/1163	480/9376	1.1421037546575	GPX3/MT-ATP8/CAPN2/BCL2/TUBB3/DKK1/ERN1/TUBB6/DDIT3/COX7A1/MAP1LC3A/MAP3K5/UBC/CACNA1C/UCHL1/ULK1/ATG101/KIF5C/EIF2AK3/PSMD8/SQSTM1/IFT57/DCTN2/NDUFS2/KLC1/RELA/GRIA1/PTGS2/MAPK10/BECN1/CSF1/TUBA1C/OPTN/WNT9A/GRIN2A/GRIA3/PPIF/PSMD2/RB1CC1/FZD8/UBE2G2/PPP3CC/UBE2G1/MAP1LC3B/HIP1/CAMK2D/FZD10/MAP2K3/MAP2K1/ZFYVE1/DAXX/DNALI1/MCU/SLC25A4/TUBA4A/NDUFA10/TUBB4B/UBE2L6/WNT5B/NDUFB1/CYCS/PSMC3/PRKCG/SEPTIN5/CSNK1A1/PINK1/MAP3K10/WNT5A	1.20268908265361
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/1163	75/9376	1.39739753511035	GPX3/ALB/CREB5/CREB3L2/ADCY1/ATP1A1/ADCY5/ADCY6/ADCY3/ATP1B2/DUOX1/TTR/PRKCG	1.3002161697036
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/1163	82/9376	1.3764234632888	UPP1/GSTM3/MGST1/NME1/DPYD/UCK2/GMPS/IMPDH2/GSTM5/CDADC1/UGT2B7/GSTM4/GSTT2B/NME4	1.28826990777373
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	10/1163	55/9376	1.46580161025561	CERS6/PLPP1/SPHK1/UGCG/SGMS2/CERS4/CERS5/KDSR/SAMD8/B4GALT5	1.30369398101031
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	34/1163	227/9376	1.20751057761145	VEGFA/MT-ATP8/EPHX1/AKT3/COX7A1/FOXO3/MAP3K5/ABL2/SOD2/GSTM3/PTPN1/MGST1/EGFR/NDUFS2/RELA/MAPK10/PRKD1/PIK3R1/CBR1/PPIF/NFKBIA/HIF1A/CYP1B1/MAP2K1/PTPN11/GSTM5/PTEN/SRC/GSTM4/SLC25A4/GSTT2B/HMOX1/NDUFA10/NDUFB1	1.19094289609467
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	13/1163	76/9376	1.37901072543784	SORBS1/APOA2/APOC3/ACSL4/PLIN2/UBC/CPT1C/APOA1/ME3/ANGPTL4/FABP3/ACSL1/SLC27A5	1.24836448848711
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/1163	90/9376	1.34365147606764	NFATC1/AKT3/BATF3/STAT3/EGFR/RELA/JAK1/PIK3R1/NFKBIA/PPP3CC/HIF1A/MAP2K3/MAP2K1/PTPN11/PTEN	1.23267819243451
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1163	23/9376	1.75258888182736	GLS/GLUL/GLUD1/ASL/ASS1	1.35978683787502
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/1163	23/9376	1.75258888182736	LARGE1/B3GALNT2/B4GALT1/POMGNT2/B4GALT2	1.35978683787502
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/1163	23/9376	1.75258888182736	ACE2/REN/ENPEP/AGT/CTSA	1.35978683787502
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1163	23/9376	1.75258888182736	ATP1A1/GLS/ATP1B2/AQP1/GLUD1	1.35978683787502
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	10/1163	56/9376	1.43962658150104	BCL2/BOC/SMURF1/GLI2/GPR161/EVC2/EVC/PTCH2/CSNK1D/CSNK1A1	1.24163682650336
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1163	36/9376	1.56759338874558	GALNT16/GALNT2/GALNT15/GALNT13/ST3GAL1/GALNT17/B4GALT5	1.28392520488773
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1163	17/9376	1.89691973091902	CYP7B1/BAAT/CH25H/SLC27A5	1.39279724532815
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/1163	17/9376	1.89691973091902	GLUL/CA12/GLUD1/CA13	1.39279724532815
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1163	50/9376	1.45114359415305	THBS1/THBS2/THBS3/ACKR1/COMP/CSF3/CCL2/THBS4/SDC2	1.20358474867082
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	30/1163	201/9376	1.20326997856804	ZBTB16/BCL6/CDKN1A/PBX1/FOXO1/GADD45B/MYC/DDIT3/NUPR1/PDGFA/PER2/MLF1/CEBPB/CDKN2C/RARA/RELA/GADD45A/GRIA3/ZBTB17/MITF/TRAF1/TFE3/SIN3A/SLC45A3/IGFBP3/NTRK1/DOT1L/WT1/CDK14/KMT2A	1.09620762289125
NA	NA	hsa04519	Cadherin signaling	57/1163	404/9376	1.13744753667112	DES/ACTN1/ENAH/CDH6/CDH13/DAAM1/MYO1D/VCL/DAAM2/LHFPL2/PCDH7/LIMA1/PDGFRB/MRAS/TEAD3/VIM/TEAD4/YWHAG/MYO1E/EGFR/RELA/RRAS/WTIP/WASF1/MAPK10/TCF7L1/CELSR2/CYFIP2/SCN4B/WNT9A/FAT3/YWHAQ/NFKBIA/YAP1/FZD8/TCF7L2/ACTG1/FZD10/MAP2K3/ROCK1/MAP2K1/PCDHB4/ACTN4/LHFPL3/LATS2/STK3/PDGFRA/TEAD2/ROCK2/WNT5B/MYO1C/PRICKLE2/SAV1/CTNNA1/CSNK1A1/SCN3B/WNT5A	1.06269244997372
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	13/1163	78/9376	1.34365147606764	ARHGAP10/ITGA5/ITGB1/VCL/SEPTIN1/CLTCL1/CLTB/WASF1/PIK3R1/CTTN/ACTG1/SRC/CTNNA1	1.14682018482294
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/1163	37/9376	1.52522599986057	GFPT2/GLS/GLUL/GLUD1/ASL/NIT2/ASS1	1.20454068919013
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	7/1163	37/9376	1.52522599986057	MAOB/AOC3/ADH1B/MAOA/ADH5/AOX1/LRTOMT	1.20454068919013
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	15/1163	93/9376	1.30030788006546	ADCY1/CACNA1C/ADCY5/EGFR/ADCY6/MAPK10/ADCY3/CAMK2D/PLA2G4C/MAP2K3/MAP2K1/ELK1/SRC/MMP14/PLA2G4A	1.09518783568136
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	14/1163	86/9376	1.31240376732188	CREB5/CREB3L2/KCNMA1/ADCY1/ATP1A1/CACNA1C/KCNMB1/ADCY5/ADCY6/ADCY3/ATP1B2/CAMK2D/ADCYAP1R1/PRKCG	1.09517170613516
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	22/1163	144/9376	1.23168051972867	INHBA/ID4/MYC/AKT3/INHBB/SMAD3/STAT3/LIF/SKIL/ACVR1B/JAK1/PIK3R1/WNT9A/FZD8/ACVR1/FZD10/LEFTY2/FGF2/MAP2K1/WNT5B/BMPR1A/WNT5A	1.0542593249824
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	11/1163	65/9376	1.36432303723791	PLPP1/LPIN1/PNPLA2/DGKI/GPAT2/LPIN2/ALDH1B1/MGLL/ALDH2/ALDH3A2/LPIN3	1.10909751696443
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	18/1163	115/9376	1.2618639949157	CREB5/BCL2/CREB3L2/AKT3/ADCY1/CACNA1C/GNG12/KCNQ3/ADCY5/GNB5/GNAO1/ADCY6/ADCY3/PIK3R1/ACHE/CAMK2D/MAP2K1/PRKCG	1.06321317909539
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	14/1163	87/9376	1.29731866654807	TPM1/CACNB2/TPM2/TPM4/COX7A1/HRC/ATP1A1/CACNA1C/CASQ2/ATP1B2/CACNA2D1/SLC9A1/CACNA2D3/SLC8A2	1.04838767186867
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	12/1163	73/9376	1.32524529146397	MAOB/ADH1B/GSTM3/MGST1/FMO2/MAOA/ADH5/AOX1/GSTM5/UGT2B7/GSTM4/GSTT2B	1.04974912614094
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1163	52/9376	1.39533037899332	APOA2/APOC3/OSBPL5/APOA1/ANGPTL4/APOB/SOAT1/LDLR/NPC1	1.07568549472397
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	30/1163	205/9376	1.17979153996183	ACTN1/CDKN1A/CREB5/GSN/CREB3L2/MAPKAPK2/STAT3/PKM/EGR3/TRAF5/HDAC4/YWHAG/STAT5B/RELA/HLA-F/HLA-B/JAK1/PIK3R1/YWHAQ/NFKBIA/SRF/STAT5A/TRAF3/ACTN4/TRAF1/SRC/SNW1/CHD4/HLA-G/GTF2H1	0.979405233210639
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	10/1163	59/9376	1.3664252298993	UPP1/NME1/DPYD/UCK2/ENTPD4/CTPS1/NT5C3B/CDADC1/NME4/ASMTL	1.06242409405906
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1163	59/9376	1.3664252298993	GPX3/GGT5/GSTM3/MGST1/ODC1/GSTM5/PRDX6/GSTM4/GSTT2B/G6PD	1.06242409405906
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	34/1163	235/9376	1.16640383454382	CNR1/BMP8A/MT-ATP8/CREB5/ACSL4/BMP8B/CREB3L2/ADCY1/COX7A1/ZNF516/SMARCD3/MAP3K5/PRKAB2/CPT1C/ADCY5/PNPLA2/NDUFAF2/NDUFS2/ADCY6/PPARGC1A/ADCY3/COX20/PRKAG2/NPPA/MGLL/ACTG1/MAP2K3/PRKAG1/NDUFAF7/ACSL1/PRDM16/NDUFA10/NDUFB1/PRKG1	0.972131443551429
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	54/1163	388/9376	1.12201824290184	SLC39A14/MT-ATP8/CAPN2/TUBB3/DKK1/INSR/AKT3/ERN1/BACE2/TUBB6/DDIT3/COX7A1/MAP3K5/CACNA1C/ULK1/ATG101/KIF5C/GAPDH/EIF2AK3/PSMD8/NDUFS2/KLC1/RELA/PTGS2/MAPK10/BECN1/IRS2/CSF1/TUBA1C/PIK3R1/WNT9A/GRIN2A/PPIF/PSMD2/RB1CC1/FZD8/PPP3CC/FZD10/SLC39A10/MAP2K1/MCU/SLC25A4/TUBA4A/NDUFA10/SLC39A11/TUBB4B/WNT5B/NDUFB1/CYCS/SLC39A7/PSMC3/BACE1/CSNK1A1/WNT5A	0.923705823859848
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/1163	39/9376	1.447009281919	MTHFD2/MAT2A/ALDH1L2/AHCYL1/MTHFD1L/BHMT2/GART	1.05261547231181
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	12/1163	75/9376	1.28990541702494	SERPINE1/THBS1/CDKN1A/BCL2/GADD45B/ZNF385A/GADD45A/BBC3/SESN2/PTEN/IGFBP3/CYCS	0.948520505533132
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	23/1163	156/9376	1.18861476729061	CDKN1A/MYC/AKT3/STAT3/PPP2R1B/YWHAG/EGFR/RELA/JAK1/PIK3R1/YWHAQ/NFKBIA/PPP2R2D/SOCS3/MAP2K1/LDLR/TRAF3/STAT2/PPP2CA/CYCS/RIPK1/CLDN12/E2F3	0.893916832049026
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1163	76/9376	1.27293297732724	MYLK/SSTR2/ADCY1/ATP1A1/ADCY5/ADCY6/ADCY3/ATP1B2/CAMK2D/ACTG1/SLC9A1/PRKCG	0.898971490157105
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1163	27/9376	1.4929460845196	OXCT1/ACAT1/AACS/OXCT2/ACAT2	0.965213322503534
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1163	27/9376	1.4929460845196	ELOVL5/TECR/HACD1/BAAT/ELOVL4	0.965213322503534
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/1163	34/9376	1.42268979818927	POLR2A/POLR1E/POLR1D/POLR2H/POLR3C/CRCP	0.929107310509979
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1163	14/9376	1.72755189780125	B4GALT1/B4GALT2/ST3GAL1	1.02510478679961
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	13/1163	85/9376	1.23299782509736	UPP1/ADA/NME1/UCK2/ENTPD2/AK1/ENTPD4/CTPS1/GMPS/NT5C3B/IMPDH2/NME4/ASMTL	0.811997485034806
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	9/1163	56/9376	1.29566392335094	HSPA1B/HSPD1/HSPA1A/RELA/HSF1/NFKBIA/CXCL1/CYCS/BNIP3	0.8350432638708
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/1163	49/9376	1.31623001737238	GALNT16/GALNT2/GALNT15/GALNT13/B4GALT1/B4GALT2/POFUT2/GALNT17	0.835131236006799
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1163	49/9376	1.31623001737238	MAOB/CREB5/CREB3L2/ADCY5/MAOA/RELA/GRIN2A/FOSB	0.835131236006799
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	24/1163	168/9376	1.15170126520084	CAPN2/BCL2/STAT3/HSP90AA1/TRAF5/SQSTM1/PYGM/STAT5B/SPATA2L/MAPK10/JAK1/GLUL/TNFAIP3/PYGB/CAMK2D/HSP90AB1/PLA2G4C/STAT6/GLUD1/STAT5A/SLC25A4/STAT2/RIPK1/PLA2G4A	0.746596195559375
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/1163	57/9376	1.27293297732724	ELOVL5/ACSL4/CPT1C/TECR/HACD1/ACAT1/ACSL1/ELOVL4/ACAT2	0.777738089474687
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/1163	88/9376	1.19096380833268	SERPINE1/C1S/C1R/SERPING1/F2R/CFH/F10/PROCR/CFB/CLU/CD59/SERPINE2/SERPINC1	0.677260713716787
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	22/1163	157/9376	1.1296942346556	IL6R/INSR/AKT3/ERN1/DDIT3/COX7A1/MAP3K5/PRKAB2/EIF2AK3/NDUFS2/RELA/MAPK10/IRS2/PIK3R1/PRKAG2/ADIPOR2/BCL2L11/SOCS3/PRKAG1/NDUFA10/NDUFB1/CYCS	0.616670500267283
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	17/1163	120/9376	1.1421037546575	NGF/NTRK2/BCL2/AKT3/NTRK3/MAPKAPK2/FOXO3/MAP3K5/RELA/MAPK10/PIK3R1/NFKBIA/CAMK2D/MAP2K1/PTPN11/NTRK1/NTF3	0.589534312363744
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	49/1163	368/9376	1.07346069011926	GPX3/MT-ATP8/BCL2/TUBB3/ERN1/TUBB6/DDIT3/COX7A1/MAP1LC3A/MAP3K5/ULK1/ATG101/KIF5C/NXT1/ANG/CHCHD10/EIF2AK3/NUP98/PSMD8/SQSTM1/DCTN2/NDUFS2/KLC1/GRIA1/BECN1/NUP153/TUBA1C/OPTN/GRIN2A/PSMD2/RB1CC1/PPP3CC/MAP1LC3B/ACTG1/MAP2K3/DAXX/DNALI1/MCU/SEC13/TUBA4A/NDUFA10/UBQLN1/TUBB4B/NDUFB1/CYCS/PSMC3/NUP88/NUP188/PINK1	0.540990088805499
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/1163	16/9376	1.5116079105761	MAOB/AOC3/MAOA	0.77069741462781
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	40/1163	298/9376	1.08213541696723	IL1RL1/CCL21/TNFRSF12A/BMP8A/INHBA/NGF/IL6R/OSMR/CCL14/BMP8B/INHBB/CSF3/IL1R1/CXCL12/RELL1/CLCF1/CCL26/BMP2/LIF/CXCL13/IL34/IL4R/ACVR1B/CCL2/CSF1/CCL19/IL1RL2/ACVR1/IL17D/PRLR/IL1RAP/GDF11/IL17RE/TNFRSF11B/TGFBR1/IL17B/CXCL1/TNFSF9/BMPR1A/IL15RA	0.542210711850822
Organismal Systems	Digestive system	hsa04976	Bile secretion	13/1163	90/9376	1.16449794592529	EPHX1/ADCY1/ATP1A1/ADCY5/ADCY6/ADCY3/ATP1B2/AQP1/BAAT/LDLR/UGT2B7/SLC9A1/SLC27A5	0.590054298508129
Human Diseases	Infectious disease: viral	hsa05162	Measles	19/1163	136/9376	1.12629609023317	BCL2/AKT3/HSPA1B/STAT3/HSPA1A/CBLB/RAB9B/STAT5B/RELA/MAPK10/JAK1/PIK3R1/NFKBIA/TNFAIP3/BBC3/STAT5A/TRAF3/STAT2/CYCS	0.558274715572795
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	12/1163	83/9376	1.16557718405868	PHC2/PHF1/CBX7/CBX6/EZH1/RING1/EZH2/TEX10/E2F6/ASXL1/L3MBTL1/YAF2	0.570146094976392
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	22/1163	160/9376	1.1085124677558	NRXN3/NLGN1/SDC4/ITGB1/NFASC/ITGAV/SLITRK4/CD276/PTPRS/HLA-DRB1/NRXN2/NEGR1/HLA-F/HLA-B/NEO1/SLITRK2/NLGN2/CNTNAP1/PVR/CLDN12/SDC2/HLA-G	0.520946329748272
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/1163	31/9376	1.30030788006546	UGDH/ALDH1B1/ALDH2/UGT2B7/ALDH3A2	0.630205960505372
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1163	31/9376	1.30030788006546	AOC3/DPYD/ALDH1B1/ALDH2/ALDH3A2	0.630205960505372
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1163	31/9376	1.30030788006546	ACO1/GLUL/HYI/ACAT1/ACAT2	0.630205960505372
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1163	24/9376	1.34365147606764	XYLT1/EXT1/NDST1/HS3ST2	0.634302129722651
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	19/1163	138/9376	1.10997295849066	ITGA5/ITGB1/NFATC1/AKT3/WIPF3/ARHGEF7/RELA/CCL2/MAPK10/PIK3R1/NFKBIA/ACTG1/MAP2K3/ROCK1/MAP2K1/PIP5K1B/SRC/ROCK2/PIP5K1A	0.489734903069374
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	16/1163	115/9376	1.12165688436951	MAOB/KCND2/CACNA1C/GNG12/ADCY5/GNB5/MAOA/GNAO1/CYP4X1/PTGS2/PLA2G4C/MAP2K1/DUSP1/HTR2A/PRKCG/PLA2G4A	0.493948023786116
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/1163	17/9376	1.42268979818927	GGT5/FMO2/BAAT	0.656381130051729
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1163	17/9376	1.42268979818927	TXNRD1/KYAT1/SCLY	0.656381130051729
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1163	17/9376	1.42268979818927	MYH11/MYH9/PCDH7	0.656381130051729
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1163	10/9376	1.61238177128117	SELENBP1/ETHE1	0.729070896315018
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1163	32/9376	1.25967325881341	ATG101/GABARAPL1/BECN1/IGBP1/PPP2CA	0.553681976629576
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	13/1163	93/9376	1.12693349605673	NFATC1/NOTCH3/HLA-DRB1/IL4R/STAT5B/RELA/MAPK10/JAK1/NFKBIA/PPP3CC/STAT6/STAT5A/JAG1	0.462911665160229
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/1163	93/9376	1.12693349605673	KCNMA1/ADCY1/ATP1A1/ATP2B4/ADCY5/CST3/ADCY6/ADCY3/ATP1B2/SLC12A2/SLC9A1/PRKCG/PRKG1	0.462911665160229
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	10/1163	70/9376	1.15170126520084	EPHX1/GSTM3/MGST1/PTGS2/CBR1/CYP1B1/GSTM5/UGT2B7/GSTM4/GSTT2B	0.479381514261376
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/1163	63/9376	1.15170126520084	GGT5/PTGIS/PTGS2/CBR1/PTGR1/PLA2G4C/PLA2G6/PLA2G4A/LTA4H	0.454610288530555
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	11/1163	79/9376	1.12254427114512	EPHX1/ADH1B/GSTM3/MGST1/ADH5/CBR1/CYP1B1/GSTM5/UGT2B7/GSTM4/GSTT2B	0.411585178819961
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	42/1163	323/9376	1.0482977460342	THBS1/TNC/TPM1/TIMP3/CDKN1A/VEGFA/HOXD10/CD44/ITGA5/BCL2/MYC/SLC7A1/PDGFA/NOTCH3/STAT3/PDGFRB/DDIT4/ITGB3/PIM1/MCL1/VIM/HDAC4/EGFR/RASSF1/GLS/PTGS2/IRS2/PIK3R1/SOX4/SPRY2/CYP1B1/RECK/BCL2L11/ROCK1/MAP2K1/EZH2/PTEN/SLC45A3/PDGFRA/HMOX1/PRKCG/E2F3	0.332396504936029
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	27/1163	205/9376	1.06181238596565	GFPT2/PLN/MT-ATP8/INSR/AKT3/COX7A1/SMAD3/REN/GAPDH/SLC2A4/NDUFS2/RELA/GYS1/COL1A1/MAPK10/PIK3R1/PPIF/AGT/CAMK2D/PTEN/TGFBR1/SLC25A4/NDUFA10/NDUFB1/COL1A2/PRKCG/G6PD	0.336719816209616
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/1163	26/9376	1.24029367021628	SLC19A2/APOA1/APOB/BTD	0.461687146168421
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1163	12/9376	1.34365147606764	VKORC1/VKORC1L1	0.448231855536603
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	24/1163	187/9376	1.03468348959219	BCL2/GBP2/PANX1/MAP1LC3A/HSP90AA1/GABARAPL1/TRAF5/RELA/CCL2/MAPK10/JAK1/NFKBIA/TNFAIP3/MAP1LC3B/HSP90AB1/TRIP6/TRAF3/TP53BP1/GBP1/MCU/STAT2/CXCL1/NOD1/RIPK1	0.180274395565094
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1163	28/9376	1.15170126520084	ELOVL5/TECR/HACD1/ELOVL4	0.302505622337247
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/1163	44/9376	1.09935120769171	CPE/HSPD1/HLA-DRB1/HLA-F/HLA-B/HLA-G	0.248563129381841
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9/1163	68/9376	1.06701734864195	ADH1B/ALDH1A3/RDH5/ALDH1A1/ALDH1A2/ADH5/AOX1/UGT2B7/DHRS3	0.208707518955717
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	13/1163	100/9376	1.04804815133276	IL6R/CD44/ITGA5/CSF3/IL1R1/ITGB3/HLA-DRB1/IL4R/CD59/CSF1/ITGA1/FLT3LG/GP1BB	0.181769451572036
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	15/1163	116/9376	1.04248821419041	MYL9/ACTN1/ITGB1/VCL/CXCL12/THY1/PIK3R1/ACTG1/ROCK1/PTPN11/ACTN4/ROCK2/PRKCG/CLDN12/CTNNA1	0.17326728216424
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	14/1163	110/9376	1.02606112717893	AKT3/ADCY1/PGR/HSP90AA1/ADCY5/ADCY6/MAPK10/ADCY3/PIK3R1/HSP90AB1/MAP2K1/CPEB1/KIF22/SPDYE2	0.103458928069206
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	10/1163	78/9376	1.03357805851357	INPP4B/ITPKC/PLCE1/TPI1/SYNJ2/PTEN/PIP5K1B/PIP5K1A/CDIPT/INPP5B	0.112055375728834
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/1163	78/9376	1.03357805851357	C1S/C1R/SERPING1/ITGA5/ITGB1/CFL2/RELA/IRF1/MAPK10/NOD1	0.112055375728834
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/1163	70/9376	1.03653113868075	CDKN1A/VEGFA/AKT3/PIK3R1/FLCN/HIF1A/MAP2K1/PTPN11/TFE3	0.115439726592173
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1163	38/9376	1.06077748110603	INSR/ATP1A1/PIK3R1/ATP1B2/PRKCG	0.14126420985734
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	13/1163	103/9376	1.0175224770221	SERPINE1/AKT3/ADCY1/PPP2R1B/GNAO1/RELA/CCL2/MAPK10/PIK3R1/NFKBIA/PPP2R2D/TGFBR1/PPP2CA	0.067286597188853
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1163	30/9376	1.07492118085411	ACO1/DLST/ACLY/IDH3A	0.154659619353446
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	8/1163	63/9376	1.0237344579563	POLE4/ERCC1/POLD4/XPC/CETN2/POLR2A/POLR2H/GTF2H1	0.0711261621011815
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	19/1163	154/9376	0.994651092673449	MTHFD2/VKORC1/MAT2A/NME1/UGDH/UGP2/AK1/MTHFD1L/CTPS1/ALDH1B1/PMM2/ALDH2/UGT2B7/FPGS/NME4/ALDH3A2/BCAT2/DHRS3/VKORC1L1	-0.0251847392725065
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	3/1163	23/9376	1.05155332909641	PCYOX1/ACAT1/ACAT2	0.0931471883875445
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1163	48/9376	1.00773860705073	AKT3/ATP1A1/HK1/HK2/PIK3R1/ATP1B2	0.0202261735254046
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	22/1163	180/9376	0.985344415782937	ITGA5/BCL2/AKT3/ITGB3/TRAF5/HLA-DRB1/RELA/HLA-F/CCL2/HLA-B/JAK1/PIK3R1/NFKBIA/SOCS3/PTPN11/TRAF3/DAXX/SRC/STAT2/CYCS/POU2F1/HLA-G	-0.0747075494315206
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	12/1163	98/9376	0.987172513029287	INPP4B/ITPKC/PLCE1/DGKI/PIK3R1/SYNJ2/PTEN/PIP5K1B/PIP5K1A/PRKCG/CDIPT/INPP5B	-0.0480343612698296
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/1163	65/9376	0.992234936173027	TRPC4/CACNA1H/AKT3/GABBR1/CACNA1C/PIK3R1/MAP2K1/PRKCG	-0.0236389471136893
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1163	15/9376	1.07492118085411	ST6GALNAC6/ST3GAL1	0.109273210954498
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1163	66/9376	0.977201073503739	RORA/NFATC1/SMAD3/STAT3/HLA-DRB1/IL4R/RELA/STAT6	-0.0699416880506369
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	18/1163	149/9376	0.973921875270505	CNR1/ADCY1/CACNA1C/GNG12/ADCY5/GNB5/GNAO1/NDUFS2/ADCY6/GRIA1/PTGS2/MAPK10/ADCY3/GRIA3/MGLL/NDUFA10/NDUFB1/PRKCG	-0.120743515463047
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1163	33/9376	0.977201073503739	ACO1/DLST/BCAT2/IDH3A	-0.0493688235382302
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/1163	67/9376	0.962615982854429	ADCY1/CACNA1C/GRIA1/GRIN2A/PPP3CC/CAMK2D/MAP2K1/PRKCG	-0.115557047639151
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	13/1163	109/9376	0.961512065442899	AKT3/CTSK/RELA/MAPK10/JAK1/PIK3R1/NFKBIA/MAP2K3/MAP2K1/TRAF3/STAT2/LBP/RIPK1	-0.152087267468484
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1163	16/9376	1.00773860705073	A4GALT/ST3GAL1	0.0116576079523534
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/1163	51/9376	0.948459865459511	PLPP1/PLA2G4C/PAFAH1B1/CHPT1/PLA2G6/PLA2G4A	-0.138877151410515
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1163	43/9376	0.937431262372773	PLPP1/APOA1/APOB/ACAT1/ACAT2	-0.154741061549432
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/1163	103/9376	0.939251517251167	PPP2R1B/NXT1/ETF1/SMG6/PPP2R2D/DDX39B/CPSF4/SMG1/DDX19A/PABPC4/PPP2CA/EIF4A3	-0.233275163288845
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1163	26/9376	0.930220252662213	PLA2G4C/PLA2G6/PLA2G4A	-0.134070998956148
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/1163	78/9376	0.930220252662213	PFKP/HSPD1/BTG1/HSPA9/ENO2/PFKM/BTG3/TOB1/PABPC4	-0.232866227302534
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	16/1163	138/9376	0.934714070307924	AR/ADCY1/PGR/PPP2R1B/ADCY5/YWHAG/ADCY6/ADCY3/YWHAQ/PPP3CC/CAMK2D/MAP2K1/CPEB1/PPP2CA/SLK/SPDYE2	-0.290733275601184
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	25/1163	214/9376	0.941811782290403	BCL2/NFATC1/AKT3/GNG12/GNB5/TRAF5/GNAO1/CFL2/RELA/NFATC4/HLA-F/HLA-B/MAPK10/PIK3R1/NFKBIA/PPP3CC/MAP2K3/SAMHD1/MAP2K1/WEE1/DCAF1/CYCS/RIPK1/PRKCG/HLA-G	-0.324019675074281
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	9/1163	79/9376	0.918445312755096	CLTCL1/CLTB/NAPA/AP2A1/SLC6A1/UNC13B/SLC6A9/STXBP1/AP2B1	-0.273914889856822
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/1163	181/9376	0.935359591074711	BCL2/SPHK1/AKT3/HSPD1/CEBPB/PLK3/HLA-DRB1/RELA/HSPA9/MAPK10/JAK1/PPP3CC/MRC2/CAMK2D/EEA1/SRC/PLA2R1/RAB7A/LBP/CYCS/VDR	-0.330439609293409
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/1163	71/9376	0.908384096496433	EGFR/RELA/MAPK10/NFKBIA/PTPN11/SRC/CXCL1/NOD1	-0.291585845875739
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1163	36/9376	0.895767650711761	UGDH/UGP2/UGT2B7/SORD	-0.235778892195341
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	4/1163	36/9376	0.895767650711761	POLE4/POLD4/RNASEH2C/RNASEH1	-0.235778892195341
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/1163	45/9376	0.895767650711761	ABCC9/ABCA8/ABCA6/ABCA5/ABCA9	-0.263735913553757
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1163	18/9376	0.895767650711761	ACSL4/ACSL1	-0.166560433579098
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/1163	54/9376	0.895767650711761	LDHA/MAT2A/AHCYL1/KYAT1/BHMT2/BCAT2	-0.289047648893099
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1163	54/9376	0.895767650711761	REV3L/ERCC1/HES1/TOP3A/MLH1/ATRIP	-0.289047648893099
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1163	37/9376	0.871557714206038	APOA1/NPPA/APOL1/PRKCG	-0.294566452331925
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1163	28/9376	0.863775948900626	A4GALT/B4GALT1/B4GALT2	-0.271642700544135
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/1163	73/9376	0.883496860975983	MAP1B/ELL2/MAP1A/ELL/NUP153/AFF4/SAMHD1/NELFE	-0.37602102656937
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	12/1163	108/9376	0.895767650711761	NXT1/NUP98/IPO5/NMD3/NUP153/DDX39B/THOC5/DDX19A/SEC13/EIF4A3/NUP88/NUP188	-0.409964239660766
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/1163	82/9376	0.884843654971373	HSPA1B/HSP90AA1/HSPA1A/HSPA4/HLA-DRB1/HLA-F/HLA-B/HSP90AB1/HLA-G	-0.394110538948441
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/1163	100/9376	0.886809974204643	CCL21/IL6R/CCL14/CXCL12/CCL26/CXCL13/IL34/CCL2/CSF1/CCL19/CXCL1	-0.428205630009715
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1163	38/9376	0.848621984884826	NNMT/AOX1/SIRT2/SIRT4	-0.3518457051175
Human Diseases	Immune disease	hsa05330	Allograft rejection	4/1163	39/9376	0.826862446810856	HLA-DRB1/HLA-F/HLA-B/HLA-G	-0.407703541507504
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	11/1163	102/9376	0.869421543337886	KCNMA1/ADCY1/ATP1A1/ATP2B4/ADCY5/ADCY6/ADCY3/ATP1B2/SLC12A2/SLC9A1/PRKCG	-0.498956466551042
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1163	30/9376	0.806190885640585	PIGT/PGAP1/PIGK	-0.400079703928081
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1163	30/9376	0.806190885640585	PLA2G4C/PLA2G6/PLA2G4A	-0.400079703928081
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	3/1163	30/9376	0.806190885640585	RELA/GART/FPGS	-0.400079703928081
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	31/1163	275/9376	0.908796998358477	MT-ATP8/CREB5/TUBB3/CREB3L2/TUBB6/STIP1/DDIT3/COX7A1/HSPA1B/HSPA1A/CACNA1C/KIF5C/EIF2AK3/PSMD8/NDUFS2/KLC1/MAPK10/TUBA1C/PIK3R1/GRIN2A/PPIF/PSMD2/PPP3CC/MCU/SLC25A4/TUBA4A/NDUFA10/TUBB4B/NDUFB1/CYCS/PSMC3	-0.5776376677078
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	28/1163	250/9376	0.902933791917455	IDS/LITAF/NCOA7/OSBPL5/OSBPL1A/CTSK/CTSF/ABCA5/CLTCL1/CLTB/LAPTM4B/AP5Z1/AP2A1/ENTPD4/CLN5/MITF/RRAGC/IGF2R/OSBP/TFE3/CTSA/TPCN1/AP2B1/RAB7A/AP3S1/PLEKHM1/NPC1/SNAPIN	-0.585359162139212
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/1163	173/9376	0.88541195532781	DNAJB1/AKT3/CALCOCO2/NXT1/HLA-DRB1/NUP98/RELA/CCL2/JAK1/PIK3R1/NFKBIA/ACTG1/CPSF4/SOCS3/MAP2K1/TRAF3/SLC25A4/STAT2/CYCS	-0.572429798524219
NA	NA	hsa04082	Neuroactive ligand signaling	22/1163	199/9376	0.89126630573331	ADRA2C/ADCY1/GABBR1/GNG12/ADCY5/ADRA2A/GNB5/GNAO1/ADCY6/GRIA1/ADCY3/GRIK2/ACHE/SLC6A1/GRIN2A/GRIA3/P2RX1/SLC6A9/GRIK5/ADRA2B/HTR2A/PRKCG	-0.583397951847856
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1163	31/9376	0.780184728039276	SRPRA/GET3/SEC63	-0.461289575783234
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	13/1163	122/9376	0.859055861748164	NFATC1/AKT3/PPP2R1B/CBLB/RELA/MAPK10/PIK3R1/NFKBIA/PPP3CC/PPP2R2D/MAP2K1/PTPN11/PPP2CA	-0.589639773300345
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	7/1163	69/9376	0.817874811519434	AKT3/MAPK10/PIK3R1/PLA2G4C/MAP2K3/MAP2K1/PLA2G4A	-0.571365859658086
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	5/1163	51/9376	0.790383221216259	TJP2/ADCY3/KDELR3/ACTG1/SLC12A2	-0.564821597476917
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	15/1163	142/9376	0.851610090465406	KLHL13/UBE2E2/UBC/CBLB/SMURF1/UBE2H/UBR5/STUB1/UBE2G2/UBE2G1/SOCS3/SAE1/UBE2R2/UBE2L6/UBA2	-0.670468210823603
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1163	12/9376	0.671825738033821	NPC1	-0.428044599323945
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	2/1163	23/9376	0.701035552730943	POLD4/MLH1	-0.540172636356195
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	12/1163	117/9376	0.826862446810856	SMARCD3/MORF4L2/CHD3/GATAD2A/CDK2AP2/BAZ1A/ACTG1/BAZ1B/EP400/CHD4/INO80B/INO80D	-0.709131453099032
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/1163	72/9376	0.783796694372791	RELA/MAPK10/NFKBIA/ZNFX1/TRAF3/RIPK1/OTUD5	-0.692976187396357
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	4/1163	45/9376	0.716614120569409	HLA-DRB1/HLA-F/HLA-B/HLA-G	-0.717042591001976
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/1163	46/9376	0.701035552730943	HEPH/HMOX2/UGT2B7/HMOX1	-0.764860482975404
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1163	46/9376	0.701035552730943	PSMD8/PSMD2/PSME4/PSMC3	-0.764860482975404
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1163	66/9376	0.732900805127804	CYP7B1/RDH5/CYP1B1/UGT2B7/SULT1E1/LRTOMT	-0.819396850522374
NA	NA	hsa03272	Virion - Hepatitis viruses	4/1163	48/9376	0.671825738033821	HSPG2/EGFR/LDLR/CLDN12	-0.857739580984747
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1163	15/9376	0.537460590427056	AK1	-0.674617857071033
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/1163	78/9376	0.723504640959499	ITGB1/HLA-DRB1/RELA/PTGS2/JAK1/NFKBIA/ELK1	-0.922709433365269
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1163	28/9376	0.575850632600418	CBR1/FPGS	-0.845791023425517
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	8/1163	91/9376	0.708739240123591	IFITM1/NFATC1/AKT3/RELA/PIK3R1/NFKBIA/PPP3CC/MAP2K1	-1.05059735840921
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/1163	41/9376	0.589895769980916	MAOB/AOC3/MAOA	-0.990269949400693
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1163	41/9376	0.589895769980916	GRIA1/GRIN2A/GRIA3	-0.990269949400693
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	7/1163	83/9376	0.679920024034228	RELA/NFKBIA/SAMHD1/POLR1D/POLR2H/RIPK1/POLR3C	-1.10215878724179
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/1163	18/9376	0.44788382535588	MTRR	-0.882266494641252
NA	NA	hsa04981	Folate transport and metabolism	2/1163	31/9376	0.520123152026184	BHMT2/FPGS	-1.00703734392754
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	4/1163	54/9376	0.597178433807841	HLA-DRB1/HLA-F/HLA-B/HLA-G	-1.11706804486673
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1163	19/9376	0.424310992442413	IDS	-0.945194110377238
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1163	19/9376	0.424310992442413	DLST	-0.945194110377238
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/1163	86/9376	0.656201883660941	PDE1A/GABBR1/CACNA1C/ADCY6/ENTPD2/PDE1B/SCN3A	-1.20522864645598
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/1163	44/9376	0.549675603845853	CHST8/B4GALT1/B4GALT2	-1.12665003018787
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/1163	44/9376	0.549675603845853	TAF4B/GTF2F1/GTF2H1	-1.12665003018787
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/1163	44/9376	0.549675603845853	APTX/POLE4/POLD4	-1.12665003018787
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/1163	33/9376	0.48860053675187	STX5/STX18	-1.10738502809696
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	1/1163	20/9376	0.403095442820292	SOAT1	-1.00554004323804
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	14/1163	158/9376	0.714346354365075	CDKN1A/GADD45B/MYC/SMAD3/PPP2R1B/CDKN2C/YWHAG/CDC14B/GADD45A/YWHAQ/ZBTB17/PPP2CA/WEE1/E2F3	-1.36261933410274
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/1163	83/9376	0.582788592029338	ACSL4/SOD2/BAAT/CRAT/ACSL1/HACL1	-1.43661976368543
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1163	50/9376	0.483714531384351	CXCL12/HLA-DRB1/IL15RA	-1.37737368775616
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	7/1163	95/9376	0.594035389419378	VEGFA/CXCL12/CTSK/HLA-DRB1/CCL2/CSF1/CXCL1	-1.49650156947515
NA	NA	hsa04382	Cornified envelope formation	19/1163	217/9376	0.705881420606964	LAMA3/COL4A2/UGCG/COL4A1/DST/PPP2R1B/S100A3/PCSK6/S100A4/PPP2R2D/PLEC/S100A6/KDSR/LAMB3/PPP2CA/COL7A1/ELOVL4/KAZN/CLDN12	-1.64950213198007
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1163	26/9376	0.310073417554071	HES1	-1.32558728920528
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/1163	41/9376	0.393263846653944	POLD4/TOP3A	-1.46507286658714
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	20/1163	238/9376	0.67747133247108	C1S/C1R/IL6R/ACE2/CSF3/STAT3/CFB/RPS26/EGFR/RPS27/RELA/CCL2/MAPK10/JAK1/PIK3R1/NFKBIA/TRAF3/RPL22L1/STAT2/PRKCG	-1.89651293095282
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/1163	32/9376	0.251934651762683	LDHA	-1.59504410486004
Human Diseases	Immune disease	hsa05310	Asthma	1/1163	32/9376	0.251934651762683	HLA-DRB1	-1.59504410486004
Human Diseases	Substance dependence	hsa05034	Alcoholism	14/1163	191/9376	0.590925256490481	MAOB/CREB5/NTRK2/CREB3L2/GNG12/ADCY5/GNB5/HDAC4/MAOA/GNAO1/GRIN2A/MAP2K1/CRH/FOSB	-2.14933620442017
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/1163	38/9376	0.212155496221206	ADA	-1.83117545004202
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/1163	56/9376	0.287925316300209	B4GALT1/B4GALT2	-2.01111167455714
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/1163	133/9376	0.484926848505615	NFATC1/HLA-B/PIK3R1/PPP3CC/MAP2K1/PTPN11/PRKCG/HLA-G	-2.25119357562542
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/1163	99/9376	0.407167113959891	C1S/C1R/CFH/CFB/HLA-DRB1	-2.23136537811039
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/1163	183/9376	0.528649761075793	REXO2/NOP58/NXT1/GNL2/NMD3/FCF1/GNL3/FBL/GTPBP4/WDR43/UTP14A/HEATR1	-2.42306592640493
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/1163	138/9376	0.408937405759717	MT-ATP8/COX7A1/NDUFS2/NDUFA10/NDUFB1/LHPP/CYCS	-2.63213781161286
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	28/1163	370/9376	0.610090399944226	CNR1/ADRA2C/AVPR1A/PTGER3/F2R/SSTR2/S1PR3/OXTR/RXFP1/PTGIR/GABBR1/EDNRA/ADRA2A/GRIA1/GRIK2/GRIN2A/GRIA3/ADM/AGT/P2RX1/PRLR/NPY1R/GRIK5/ADRA2B/HTR2A/ADCYAP1R1/CHRNA5/CRH	-2.87954190502499
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	11/1163	195/9376	0.454774345745971	AKT3/ITGB3/HDAC4/RELA/PIK3R1/PPIF/ACTG1/MAP2K1/SRC/SLC25A4/PRKCG	-2.89516405701665
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/1163	143/9376	0.338261910058987	C1S/C1R/ACTN1/HLA-DRB1/GRIN2A/ACTN4	-3.00059456748492
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/1163	243/9376	0.364942376215903	HSPA1B/HSPA1A/PQBP1/SNRNP70/DDX39B/THOC5/SNIP1/SNW1/EIF4A3/SNRPA/CWC25	-3.77428009061994
Genetic Information Processing	Translation	hsa03010	Ribosome	5/1163	222/9376	0.181574523792924	RPS26/MRPL18/RPS27/MRPL24/RPL22L1	-4.64381336491193
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/1163	449/9376	0.107731521466448	PDE1A/ADCY3/PDE1B/CAMK2D/PRKG1/SLC8A2	-7.2910577484468