category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04518	Integrin signaling	24/295	154/9376	4.95320272947392	FLT1/ITGA5/EGFR/FN1/PIK3CB/FBN1/FLNB/PTK2/LAMB1/COL4A1/ITGB1/TNC/VEGFA/THBS1/COL4A2/AKT3/PIK3R1/PDGFD/LAMA3/THBS3/LAMB3/ACTN1/CDH1/FERMT2	8.91510979976895
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	26/295	203/9376	4.07073557652167	FLT1/ITGA5/EGFR/FN1/PIK3CB/FLNB/PTK2/LAMB1/COL4A1/PPP1R12B/ITGB1/TNC/VEGFA/DIAPH1/THBS1/COL4A2/AKT3/PIK3R1/VAV2/PDGFD/LAMA3/DOCK1/THBS3/RAPGEF1/LAMB3/ACTN1	7.97194972499509
NA	NA	hsa04517	IgSF CAM signaling	28/295	299/9376	2.97633920979536	RASA1/EZR/ITGA5/TRIO/PIK3CB/IL1RAP/PTPRF/PARD3/FOXO1/PTK2/GRIP1/RAPGEF2/ITGB1/SORBS1/AKT3/PIK3R1/KCNQ3/VAV2/MYH11/ACTR3C/AFDN/FGFR1/TJP2/ACTN1/PLCG2/CDH1/NLGN1/PVR	6.25973173678768
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	24/295	232/9376	3.28790181180596	EZR/ITGA5/EGFR/FN1/PIK3CB/SSH2/PTK2/TIAM1/PPP1R12B/ITGB1/DIAPH1/AKT3/PIK3R1/VAV2/PDGFD/DOCK1/MYH11/C7/ACTR3C/ARHGEF7/FGFR1/RRAS2/ACTN1/KNG1	6.35979437602922
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	22/295	204/9376	3.4275839149219	TIMP3/EZR/ITGA5/EGFR/FN1/PIK3CB/PTK2/TIAM1/PPP1R12B/ITGB1/VEGFA/CAMK2G/THBS1/AKT3/PIK3R1/HSPG2/VAV2/CBL/IGF2/FGFR1/RRAS2/PLCG2	6.31810908966155
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	15/295	101/9376	4.72025507635509	SERPINE1/FN1/PIK3CB/FOXO1/COL4A1/VEGFA/DIAPH1/COL4A2/AKT3/PIK3R1/SMAD3/PRKCE/PRKCZ/F3/PLCG2	6.77495249053547
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/295	110/9376	4.33405238828968	FLT1/SERPINE1/EGFR/PIK3CB/TF/EPAS1/INSR/VEGFA/CAMK2G/AKT3/PIK3R1/EGLN3/ALDOB/PLCG2/HK2	6.33946228779429
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	28/295	333/9376	2.67244871990635	TCF7L2/ITGA5/EGFR/FN1/PIK3CB/CREB5/PARD3/FOXO1/PTK2/HLA-G/LAMB1/COL4A1/CREB3L2/ITGB1/TNC/VEGFA/THBS1/COL4A2/AKT3/PIK3R1/PRKCZ/LAMA3/THBS3/LAMB3/AXIN1/LLGL2/PTGS2/JAK1	5.60077943664476
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	29/295	362/9376	2.54615600711677	FLT1/ITGA5/EGFR/FN1/PIK3CB/CREB5/PTK2/INSR/LAMB1/COL4A1/CREB3L2/ITGB1/TNC/VEGFA/THBS1/COL4A2/AKT3/PIK3R1/YWHAZ/PDGFD/LAMA3/PRLR/THBS3/LAMB3/IGF2/FGFR1/JAK1/RXRA/GYS1	5.40727713678937
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/295	233/9376	3.00097475812905	FMNL2/ITGA5/SYNE2/FN1/TPM1/FBN1/COL27A1/COL4A1/DSP/ACTG2/ITGB1/DIAPH1/THBS1/COL4A2/PKP2/HSPG2/DES/MYH11/PDLIM5/THBS3/TNNI2/FBN2	5.57448843913068
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	12/295	78/9376	4.8897001303781	ITGA5/FN1/PIK3CB/PTK2/ITGB1/PIK3R1/ARHGAP10/DOCK1/ACTR3C/CBL/CTNNA1/CDH1	6.21725184973563
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	13/295	93/9376	4.44279205394569	TCF7L2/EGFR/PTPRF/PARD3/INSR/SORBS1/SMAD3/AFDN/FGFR1/ACTN1/SMURF1/CTNNA1/CDH1	6.01364655452157
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	13/295	93/9376	4.44279205394569	FN1/PIK3CB/PTK2/LAMB1/COL4A1/ITGB1/COL4A2/AKT3/PIK3R1/LAMA3/LAMB3/PTGS2/RXRA	6.01364655452157
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/295	109/9376	4.08222671435236	PIK3CB/PTPRF/CREB5/FOXO1/INSR/PRKAG2/CREB3L2/AKT3/PIK3R1/PRKCE/PRKCZ/CPT1B/GFPT1/GYS1	5.83361892740839
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	20/295	212/9376	2.99840102334506	FLT1/EGFR/PIK3CB/PARD3/INSR/TIAM1/RAPGEF2/ITGB1/VEGFA/THBS1/AKT3/PIK3R1/VAV2/PDGFD/PRKCZ/AFDN/RAPGEF1/FGFR1/CDH1/CNR1	5.30441924409867
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	12/295	89/9376	4.28535517044372	ITGA5/FN1/LAMB1/COL4A1/ITGB1/TNC/THBS1/COL4A2/HSPG2/LAMA3/THBS3/LAMB3	5.61266880185846
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	15/295	138/9376	3.45467943994105	PIK3CB/PTPRF/FOXO1/INSR/PRKAG2/SORBS1/AKT3/PIK3R1/CBLB/PRKCZ/CBL/RAPGEF1/PRKAR2B/HK2/GYS1	5.23570486619679
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/295	116/9376	3.56189362945646	EZR/PIK3CB/PTK2/ITGB1/PIK3R1/CLDN4/PTK2B/VAV2/AFDN/ACTN1/CTNNA1/PLCG2/CD99L2	5.00396661306375
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	16/295	170/9376	2.99134596211366	EZR/PARD3/TIAM1/PRKAG2/RAPGEF2/ITGB1/RAB8B/CLDN4/PRKCE/PRKCZ/MYH11/ACTR3C/AFDN/TJP2/LLGL2/ACTN1	4.72242969980441
NA	NA	hsa04519	Cadherin signaling	27/295	404/9376	2.12411478435979	TEAD1/TCF7L2/EGFR/WWTR1/PTK2/DSP/LIMA1/PKP2/ANKRD6/DES/PTK2B/VAV2/YWHAZ/ACTR3C/AFDN/FAT1/FGFR1/AXIN1/MYO1E/RRAS2/TMC1/FMN1/ACTN1/PCDH7/CTNNA1/CDH1/KRT6A	4.16280931925944
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/295	103/9376	3.39430640118479	FN1/PIK3CB/PTK2/LAMB1/COL4A1/COL4A2/PIK3R1/LAMA3/LAMB3/ACTN1/IL1R1	4.40370296318082
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	12/295	122/9376	3.12620172270075	PIK3CB/CREB5/FOXO1/INSR/PRKAG2/CREB3L2/AKT3/PIK3R1/CPT1B/LEP/PPARG/GYS1	4.2603908354114
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	8/295	59/9376	4.30956621660442	TCF7L2/EGFR/PIK3CB/AKT3/PIK3R1/AXIN1/CTNNA1/CDH1	4.59609335214671
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	10/295	98/9376	3.24316845382221	PIK3CB/ASAP3/AKT3/PIK3R1/PRKCE/VAV2/DOCK1/ACTR3C/PLCG2/ASAP1	4.02325491819067
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	18/295	253/9376	2.26124472432505	ITGA5/EGFR/PIK3CB/FOXO1/PTK2/ITGB1/DIAPH1/AKT3/PIK3R1/PRKCE/DOCK1/ACTR3C/ACTN1/PLCG2/CYTH3/HK2/IL1R1/CCL5	3.66539340527947
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	12/295	138/9376	2.76374355195284	ITGA5/FN1/PIK3CB/PTK2/ITGB1/AKT3/PIK3R1/PTK2B/VAV2/DOCK1/ACTR3C/ARHGEF7	3.76197418995959
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	17/295	238/9376	2.27021791767554	FLT1/RASA1/EGFR/PIK3CB/RASAL2/RASGRF2/INSR/TIAM1/VEGFA/AKT3/PIK3R1/PDGFD/AFDN/IGF2/FGFR1/RRAS2/PLCG2	3.5774283524854
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	9/295	86/9376	3.32613322822231	EGFR/PIK3CB/PTK2/CAMK2G/AKT3/PIK3R1/CBLB/CBL/PLCG2	3.90576187716549
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	10/295	106/9376	2.99840102334506	TCF7L2/EGFR/PIK3CB/CREB5/FOXO1/CREB3L2/AKT3/PIK3R1/PDGFD/FGFR1	3.72928451041439
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/295	90/9376	3.17830508474576	PIK3CB/CREB5/FOXO1/INSR/PRKAG2/CREB3L2/AKT3/PIK3R1/PPARG	3.74244501802573
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	17/295	250/9376	2.16124745762712	EGFR/PARD3/HLA-G/ASAP3/LDLR/CBLB/SMAD3/RAB11FIP3/PRKCZ/ACTR3C/CBL/GBF1/SMURF1/CYTH3/ARFGAP1/ASAP1/CBLC	3.35416448866319
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/295	59/9376	3.77087043952887	PIK3CB/INSR/AKT3/PIK3R1/CGA/MGLL/PTGS2	3.84799045351769
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	7/295	60/9376	3.70802259887006	PIK3CB/PTK2/VEGFA/AKT3/PIK3R1/PTGS2/PLCG2	3.79265184849427
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/295	133/9376	2.62867337836116	EGFR/PIK3CB/HOMER1/FOXO1/INSR/PRKAG2/FBXO32/AKT3/PIK3R1/SMAD3/TNFSF10	3.4094407685601
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	6/295	47/9376	4.05741074648395	PIK3CB/INSR/PIK3R1/PRKCE/PRKCZ/HK2	3.78717155380105
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/295	80/9376	3.17830508474576	EGFR/PIK3CB/VEGFA/AKT3/PIK3R1/PDGFD/JAK1/PLCG2	3.52651267853522
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/295	157/9376	2.4292777717802	SERPINE1/TEAD1/TCF7L2/WWTR1/PARD3/SMAD3/YWHAZ/PRKCZ/AXIN1/LLGL2/CTNNA1/CDH1	3.2550252860716
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/295	142/9376	2.46206731916925	UBE2K/HERC1/CBLB/UBR5/UBE2G1/CBL/UBE2H/MID1/SMURF1/CBLC/HERC4	3.16407241946365
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	13/295	184/9376	2.24554163596168	RASA1/PIK3CB/SSH2/PARD3/PTK2/ITGB1/SEMA5A/CAMK2G/PIK3R1/PRKCZ/SEMA6D/EPHB2/PLCG2	3.07533167755122
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	15/295	227/9376	2.10020159784962	EGFR/PIK3CB/CREB5/PTK2/HLA-G/AKAP13/CREB3L2/VEGFA/AKT3/PIK3R1/PTK2B/PTGS2/JAK1/IL1R1/CCL5	3.02432315468603
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	8/295	86/9376	2.95656286953094	TCF7L2/ITGA5/DSP/ITGB1/PKP2/DES/CTNNA1/CACNB2	3.2852239817457
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/295	125/9376	2.54264406779661	PIK3CB/SGPP1/AKT3/PIK3R1/PRKCE/CERS6/PRKCZ/ACER2/SGMS2/KNG1	3.12936490540176
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	7/295	70/9376	3.17830508474576	PIK3CB/EPAS1/VEGFA/AKT3/PIK3R1/RAPGEF1/EGLN3	3.29697769857076
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	11/295	149/9376	2.34639972699352	EGFR/PIK3CB/INSR/AKT3/PIK3R1/DGKI/PTK2B/PDGFD/RRAS2/PLCG2/CYTH3	2.98584113689536
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	6/295	55/9376	3.46724191063174	HEXB/SGPP1/B4GALT5/CERS6/ACER2/SGMS2	3.30743739851243
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	10/295	130/9376	2.44485006518905	EGFR/PIK3CB/CREB5/COL4A1/CREB3L2/VEGFA/COL4A2/AKT3/PIK3R1/PRKCZ	2.98983569014544
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/295	73/9376	3.04768980729046	EGFR/PIK3CB/AKT3/PIK3R1/PDGFD/FGFR1/CDH1	3.16551150615144
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	5/295	41/9376	3.87598181066556	EGFR/VEGFA/THBS1/DAPK1/CDH1	3.3262180086552
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	7/295	76/9376	2.92738626226583	APOA2/APOC3/APOA1/SORBS1/CPT1B/RXRA/PPARG	3.04063219332236
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/295	115/9376	2.48736919675755	EGFR/CREB5/AKAP13/CREB3L2/GATA3/FGFR1/WNK2/GCM1/RXRA	2.89246804347015
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	7/295	77/9376	2.88936825885978	EGFR/PIK3CB/VEGFA/AKT3/PIK3R1/SMAD3/JAK1	3.00036203900891
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	11/295	157/9376	2.22683795746518	SERPINE1/PIK3CB/FOXO1/HLA-G/AKT3/PIK3R1/SMAD3/RRAS2/ZFP36L2/IGFBP3/HIPK3	2.79399054005279
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	14/295	226/9376	1.96886155692215	PIK3CB/CREB5/TIAM1/CREB3L2/CAMK2G/AKT3/PIK3R1/VAV2/PDE10A/CGA/AFDN/CRH/RRAS2/OXTR	2.657267065983
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/295	99/9376	2.5683273412087	PIK3CB/IL1RAP/CAMK2G/PIK3R1/PRKCE/KNG1/PLCG2/IL1R1	2.82735499719858
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	9/295	119/9376	2.40376014812705	PIK3CB/CREB5/CREB3L2/DAB2IP/AKT3/PIK3R1/TNFAIP3/PTGS2/CCL5	2.77754475859876
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	13/295	205/9376	2.01551054154609	MT-ATP8/PIK3CB/INSR/MT-ND4L/CAMK2G/AKT3/PIK3R1/SMAD3/PRKCZ/CPT1B/PDK4/GFPT1/GYS1	2.64961533183747
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	6/295	62/9376	3.07577911427009	PIK3CB/FOXO1/INSR/PRKAG2/AKT3/PIK3R1	2.95555247294177
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	17/295	300/9376	1.8010395480226	FLT1/RASA1/EGFR/IL1RAP/RASGRF2/INSR/RAPGEF2/VEGFA/MAPK8IP3/AKT3/MAP3K9/PDGFD/IGF2/FGFR1/RRAS2/CACNB2/IL1R1	2.54154117618333
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/295	122/9376	2.34465129202556	PIK3CB/FOXO1/NCOA1/THRB/MED13L/AKT3/PIK3R1/PLCG2/RXRA	2.69435396472778
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/295	17/9376	5.60877367896311	MYH11/PCDH7/LAMP2	3.42787461064305
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/295	103/9376	2.46858647358894	COL27A1/COL4A1/MME/COL4A2/COL12A1/SLC38A2/COL7A1/PRCP	2.70108228513722
NA	NA	hsa03272	Virion - Hepatitis viruses	5/295	48/9376	3.31073446327684	EGFR/LDLR/CLDN4/HSPG2/LAMP2	2.89271867920177
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	12/295	193/9376	1.97614823922016	PIK3CB/PARD3/PTK2/TIAM1/AKT3/PIK3R1/PTK2B/VAV2/CCL21/PRKCZ/PLCG2/CCL5	2.46963030595333
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	13/295	216/9376	1.91286880100439	PIK3CB/PTK2/APOB/APOA1/CAMK2G/LDLR/AKT3/PIK3R1/VAV2/TNFSF10/RXRA/PPARG/CCL5	2.44634278882964
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	8/295	107/9376	2.37630286709964	CREB5/FOXO1/PRKAG2/CREB3L2/CAMK2G/AKT3/CPT1B/GYS1	2.58059154905648
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	7/295	87/9376	2.55725696473797	TCF7L2/EGFR/PIK3CB/AKT3/PIK3R1/SMAD3/AXIN1	2.63005744979527
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/295	194/9376	1.96596190809016	TPM1/KIF21A/ACTG2/MYH11/MYO5B/MYO6/KIF2A/MYO18A/MYO1E/TNNI2/MYO9B/KIFC2	2.45031562724345
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	6/295	68/9376	2.80438683948156	TCF7L2/PIK3CB/ZBTB16/AKT3/PIK3R1/PER2	2.69144635640281
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	10/295	150/9376	2.11887005649717	TCF7L2/EGFR/PIK3CB/AKT3/PIK3R1/SMAD3/AXIN1/CTNNA1/RXRA/CDH1	2.48970770902581
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/295	88/9376	2.52819722650231	SERPINE1/SERPINE2/C7/F3/CD46/KNG1/SERPINC1	2.59590890485258
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/295	52/9376	3.05606258148631	APOA2/APOC3/APOB/APOA1/LDLR	2.6795796884437
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/295	71/9376	2.68589162091191	EGFR/PIK3CB/AKT3/PIK3R1/FGFR1/HK2	2.56998415740976
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	12/295	200/9376	1.90698305084746	EZR/ITGB1/BAIAP2L1/CLDN4/MYH11/TNFSF10/MYO5B/MYO6/ACTR3C/MYO1E/CYTH3/IL1R1	2.33677703038005
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	12/295	201/9376	1.89749557298254	FLT1/AFF1/ZBTB16/FOXO1/PTK2/KDM6A/FUT8/RXRA/IGFBP3/MYCN/PPARG/PER2	2.31823317042943
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/295	36/9376	3.53145009416196	GALNT15/B4GALT5/GCNT1/GALNT17	2.74269168958857
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	10/295	157/9376	2.02439814315017	PTK2/CAMK2G/THBS1/DOCK1/ATP11A/ANO9/CPT1B/PTGS2/RXRA/PPARG	2.33295579403397
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	6/295	73/9376	2.61230554910611	EGFR/PIK3CB/AKT3/PIK3R1/PLCG2/RXRA	2.49245356838524
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/295	37/9376	3.43600549702245	GMDS/HK2/GFPT1/UGP2	2.67583140571881
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	4/295	37/9376	3.43600549702245	TCF7L2/RXRA/CDH1/PPARG	2.67583140571881
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	10/295	160/9376	1.9864406779661	PTPRF/HLA-G/NRXN3/ITGB1/CLDN4/CD22/CD99L2/CDH1/NLGN1/PVR	2.26824279300421
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/295	38/9376	3.34558429973238	HEXB/HK2/GFPT1/UGP2	2.61123355477468
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/295	56/9376	2.83777239709443	MGAT5/MAN2A1/FUT8/DHRSX/MGAT1	2.48603701089419
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	9/295	139/9376	2.05789537861236	EGFR/PIK3CB/CREB5/CREB3L2/NCOA1/AKT3/PIK3R1/FKBP5/GREB1	2.26471969330241
Human Diseases	Cancer: specific types	hsa05214	Glioma	6/295	76/9376	2.50918822479929	EGFR/PIK3CB/CAMK2G/AKT3/PIK3R1/PLCG2	2.38088565429176
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	10/295	163/9376	1.94988042008942	PIK3CB/CREB5/CREB3L2/AKT3/PIK3R1/SMAD3/HSPG2/PTK2B/YWHAZ/JAK1	2.2049158054333
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/295	77/9376	2.47660136473696	PIK3CB/CTBP2/AKT3/PIK3R1/SMAD3/CBL	2.34487832677955
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	7/295	98/9376	2.27021791767554	PIK3CB/PIK3R1/DGKI/SYNJ2/PLCG2/INPP5B/PI4KA	2.27821074951114
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/295	144/9376	1.9864406779661	PIK3CB/INHBA/AKT3/PIK3R1/SMAD3/JARID2/FGFR1/AXIN1/JAK1	2.14997856213538
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	8/295	122/9376	2.0841344818005	PIK3CB/CREB5/PTK2/CREB3L2/AKT3/PIK3R1/PLCG2/IGFBP3	2.17234167449991
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	7/295	105/9376	2.11887005649717	PIK3CB/AKT3/PIK3R1/CBLB/RRAS2/PTGS2/PLCG2	2.07797739410525
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/295	44/9376	2.88936825885978	HEXB/MAN2A1/FUT8/MGAT1	2.26404678245792
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	9/295	156/9376	1.83363754889179	EGFR/PIK3CB/LDLR/AKT3/PIK3R1/CLDN4/YWHAZ/JAK1/RXRA	1.89236067742918
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	7/295	110/9376	2.02255778120185	FBN1/TF/INHBA/LTBP1/THBS1/SMAD3/SMURF1	1.94432052531279
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	7/295	112/9376	1.9864406779661	LAMB1/ITGB1/LDLR/AKT3/LAMA3/LAMB3/JAK1	1.89282524458418
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/295	48/9376	2.64858757062147	PIK3CB/AKT3/PIK3R1/HK2	2.0638027153816
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/295	69/9376	2.30311962662736	PIK3CB/AKT3/PIK3R1/VAV2/PLCG2	1.95809510900134
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	6/295	91/9376	2.09558577016204	PIK3CB/AKT3/PIK3R1/CD22/VAV2/PLCG2	1.89280525635222
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	5/295	70/9376	2.27021791767554	PRKAG2/AKT3/CPT1B/LEP/RXRA	1.92254068368483
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	7/295	115/9376	1.93462048636699	PIK3CB/CREB5/CREB3L2/CAMK2G/AKT3/PIK3R1/KCNQ3	1.81754462542476
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	5/295	71/9376	2.23824301742659	PIK3CB/AKT3/PIK3R1/PRLR/CGA	1.88758571330243
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	8/295	142/9376	1.79059441394127	PIK3CB/AKT3/PIK3R1/FOSB/JAK1/PLCG2/IL1R1/PPARG	1.71093214883906
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/295	52/9376	2.44485006518905	INSR/LDLR/CGA/PTGS2	1.88301218182201
NA	NA	hsa04382	Cornified envelope formation	11/295	217/9376	1.6111223931891	PCSK6/COL4A1/DSP/COL4A2/PKP2/CLDN4/LAMA3/LAMB3/S100A8/COL7A1/KRT6A	1.64158677061671
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/295	75/9376	2.11887005649717	ALB/GPX3/CREB5/CREB3L2/CGA	1.75337685376181
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	9/295	170/9376	1.68263210368893	TCF7L2/EGFR/PIK3CB/AKT3/PIK3R1/SMAD3/IGF2/AXIN1/PLCG2	1.61884583685242
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	6/295	98/9376	1.94590107229332	CREB5/DAGLB/CREB3L2/CAMK2G/LDLR/PRKCE	1.6965293599513
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	10/295	196/9376	1.6215842269111	TCF7L2/PIK3CB/HLA-G/VEGFA/AKT3/PIK3R1/PTGS2/JAK1/PLCG2/ZFP36	1.58502635875374
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/295	99/9376	1.92624550590652	EGFR/PIK3CB/AKT3/PIK3R1/DGKI/PDGFD	1.66982031808438
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/295	99/9376	1.92624550590652	ITGA5/TPM1/PRKAG2/ITGB1/DES/CACNB2	1.66982031808438
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/295	148/9376	1.71800274851122	TCF7L2/EGFR/PIK3CB/NCOA1/AKT3/PIK3R1/FGFR1/AXIN1	1.58683941722093
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	11/295	224/9376	1.56077481840194	PIK3CB/CREB5/HLA-G/CREB3L2/AKT3/PIK3R1/SMAD3/CRTC3/JAK1/IL1R1/ZFP36	1.531032166532
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/295	35/9376	2.72426150121065	GMDS/ALDOB/HK2	1.84191793206184
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/295	17/9376	3.73918245264207	GGT5/BAAT	2.03732589998718
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/295	78/9376	2.03737505432421	PIK3CB/SYNJ2/PLCG2/INPP5B/PI4KA	1.65812832845288
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/295	36/9376	2.64858757062147	CRPPA/UGT2B7/UGP2	1.78615704885124
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3/295	36/9376	2.64858757062147	HK2/UGP2/GYS1	1.78615704885124
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	6/295	103/9376	1.85143985519171	SERPINE1/PIK3CB/AKT3/PIK3R1/KNG1/CCL5	1.56600183310815
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	9/295	178/9376	1.6070081889164	TCF7L2/CTBP2/CAMK2G/SMAD3/ANKRD6/AXIN1/TLE6/SFRP1/NOTUM	1.47362729443286
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	9/295	180/9376	1.58915254237288	ITGA5/PIK3CB/HLA-G/AKT3/PIK3R1/JAK1/PILRB/CCL5/NXF1	1.43844855977119
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	8/295	155/9376	1.64041552761072	TCF7L2/EGFR/CREB5/CREB3L2/CAMK2G/LDLR/CRH/AXIN1	1.44900038134761
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/295	38/9376	2.50918822479929	PIK3CB/INSR/PIK3R1	1.680111404871
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/295	157/9376	1.61951851452013	PIK3CB/INSR/PRKAG2/AKT3/PIK3R1/LEP/RXRA/PPARG	1.41088630199635
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	8/295	158/9376	1.60926839733963	PIK3CB/INSR/AKT3/PIK3R1/GRB10/CASTOR2/LPIN1/CLIP1	1.39203018232942
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/295	133/9376	1.67279214986619	PIK3CB/HLA-G/PIK3R1/PTK2B/VAV2/TNFSF10/PLCG2	1.40841313856874
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	6/295	109/9376	1.74952573472244	IL1RAP/GATA3/SMAD3/JAK1/RXRA/IL1R1	1.41860022570574
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/295	20/9376	3.17830508474576	GMDS/UGP2	1.75759336669467
Human Diseases	Infectious disease: viral	hsa05162	Measles	7/295	136/9376	1.63589232303091	PIK3CB/AKT3/PIK3R1/CBLB/TNFAIP3/CD46/JAK1	1.34631554030327
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	14/295	323/9376	1.37759353518392	TIMP3/EZR/ITGA5/EGFR/PIK3CB/TPM1/TNC/VEGFA/THBS1/PIK3R1/PRKCE/SLC7A1/PTGS2/PLCG2	1.2446847238041
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/295	42/9376	2.27021791767554	SAT1/TF/SLC39A14	1.48695830157278
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	10/295	217/9376	1.464656721081	EGFR/PIK3CB/CREB5/CREB3L2/VEGFA/AKT3/PIK3R1/RXRA/UGT2B7/KLF5	1.24815312727164
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	4/295	65/9376	1.95588005215124	PIK3CB/AKT3/PIK3R1/CGA	1.39377195627621
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	7/295	140/9376	1.58915254237288	SERPINE1/PRKAG2/AKT3/SMAD3/PRKCE/RRAS2/CDH1	1.26584234671085
NA	NA	hsa04081	Hormone signaling	10/295	219/9376	1.4512808606145	PIK3CB/INSR/THRB/PIK3R1/PRLR/CGA/CRH/IGF2/OXTR/LEP	1.21792956669325
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	5/295	90/9376	1.76572504708098	EGFR/PIK3CB/AKT3/PIK3R1/JAK1	1.31555671778648
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	8/295	168/9376	1.5134786117837	EGFR/PIK3CB/AKT3/PIK3R1/PRLR/JAK1/CSF2RA/LEP	1.21038672614731
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	7/295	142/9376	1.56677011219862	PIK3CB/PTK2/VEGFA/AKT3/PIK3R1/PRKCZ/IL1R1	1.22655205863087
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/295	23/9376	2.76374355195284	MME/PRCP	1.52634847889254
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	4/295	69/9376	1.84249570130189	CREB5/CREB3L2/CAMK2G/FOSB	1.26595185765368
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	6/295	120/9376	1.58915254237288	PIK3CB/CAMK2G/AKT3/PIK3R1/RAPGEF1/PLCG2	1.17067545967686
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/295	26/9376	2.44485006518905	APOB/APOA1	1.32963812358315
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	9/295	205/9376	1.3953534518396	PIK3CB/CREB5/HLA-G/CREB3L2/PIK3R1/YWHAZ/SND1/ACTN1/JAK1	1.03153490252719
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	3/295	49/9376	1.94590107229332	CREB5/CREB3L2/FOSB	1.19647210503866
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/295	99/9376	1.60520458825544	EGFR/PIK3CB/PTK2/AKT3/PIK3R1	1.09105297852728
Organismal Systems	Immune system	hsa04611	Platelet activation	6/295	126/9376	1.5134786117837	PIK3CB/ITGB1/AKT3/PIK3R1/PRKCZ/PLCG2	1.04584319021558
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	10/295	235/9376	1.35247024882798	MT-ATP8/CREB5/MT-ND4L/PRKAG2/CREB3L2/FGFR1/CPT1B/MGLL/CNR1/PPARG	0.986255300153105
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	5/295	100/9376	1.58915254237288	ITGA5/MME/CD22/CSF2RA/IL1R1	1.06752288629399
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	7/295	154/9376	1.44468412942989	EGFR/PRKAG2/PPP1R12B/CAMK2G/OXTR/PTGS2/CACNB2	1.00283443865014
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/295	29/9376	2.19193454120397	TEAD1/WWTR1	1.15863085914705
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	9/295	214/9376	1.33667036274355	PIK3CB/PTK2/HLA-G/AKT3/PIK3R1/PTK2B/WEE1/PLCG2/DCAF1	0.897938180469913
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	5/295	105/9376	1.5134786117837	TNFAIP3/CCL21/PTGS2/PLCG2/IL1R1	0.953637950579797
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/295	105/9376	1.5134786117837	ITGA5/TPM1/ITGB1/DES/CACNB2	0.953637950579797
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	5/295	109/9376	1.4579381122687	PIK3CB/AKT3/PIK3R1/JAK1/CCL5	0.866722887992903
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/295	32/9376	1.9864406779661	HK2/UGP2	1.00741718650385
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/295	166/9376	1.34024913212171	CREB5/INSR/CREB3L2/AKT3/PRKCE/KCNMA1/KNG1	0.797170214597367
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	10/295	254/9376	1.25130121446684	FLT1/EGFR/VEGFA/CAMK2G/CASQ1/PTK2B/PDGFD/FGFR1/OXTR/PLCG2	0.73180642838455
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	4/295	86/9376	1.47828143476547	CREB5/CREB3L2/CAMK2G/KCNMA1	0.803072400066528
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/295	34/9376	1.86959122632104	PRKAG2/PER2	0.915512935040423
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	6/295	144/9376	1.32429378531073	TCF7L2/FOXO1/PRKAG2/AKT3/LPIN1/CPT1B	0.706808530736372
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/295	61/9376	1.56310086135038	TF/MT1X/STEAP2	0.795224016904071
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	5/295	116/9376	1.36995908825248	HOMER1/SHANK2/SLC1A3/SLC38A2/SLC38A1	0.72261506275251
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/295	173/9376	1.28601939845204	PIK3CB/AKT3/PIK3R1/TNFSF10/JAK1/CCL5/NXF1	0.684358456011966
Organismal Systems	Digestive system	hsa04976	Bile secretion	4/295	90/9376	1.41258003766478	LDLR/RXRA/UGT2B7/BAAT	0.708834642726663
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/295	12/9376	2.64858757062147	CD46	1.02991586954048
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/295	37/9376	1.71800274851122	APOA1/KNG1	0.78869046322232
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	3/295	65/9376	1.46691003911343	DGKI/LPIN1/MGLL	0.680803116620708
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	3/295	65/9376	1.46691003911343	CREB5/CREB3L2/LDLR	0.680803116620708
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/295	93/9376	1.3670129396756	EGFR/CAMK2G/PTK2B/CGA	0.641074472568131
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	5/295	122/9376	1.30258405112531	PIK3CB/AKT3/PIK3R1/CBLB/VAV2	0.60630480381629
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	4/295	94/9376	1.35247024882798	TNFAIP3/FOSB/PTGS2/S100A8	0.619006797583694
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	6/295	154/9376	1.23830068236848	TPM1/CREB5/CREB3L2/CAMK2G/AKT3/CACNB2	0.537406476231381
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/295	14/9376	2.27021791767554	FUT8	0.857211013784707
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	6/295	155/9376	1.23031164570804	ITGA5/HLA-G/ITGB1/THBS1/THBS3/LAMP2	0.521101766074912
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	9/295	248/9376	1.15341716785129	TCF7L2/PIK3CB/AKT3/AHNAK/TNFSF10/MYO6/ACTR3C/ANXA2/CYTH3	0.441307993798237
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/295	15/9376	2.11887005649717	HEXB	0.781616945883295
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	3/295	71/9376	1.34294581045596	EGFR/PLCG2/CCL5	0.522788825087772
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/295	43/9376	1.47828143476547	APOB/APOA1	0.566548281584327
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/295	16/9376	1.9864406779661	HEXB	0.711742416190441
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/295	44/9376	1.44468412942989	CREB5/CREB3L2	0.532868945863118
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	5/295	134/9376	1.18593473311409	PPP1R12B/ACTG2/PRKCE/MYH11/KCNMA1	0.390714699130139
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/295	104/9376	1.22242503259452	LPCAT1/DGKI/LPIN1/SGMS2	0.41109616880175
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/295	17/9376	1.86959122632104	BAAT	0.646777189331301
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	3/295	75/9376	1.27132203389831	PIK3CB/AKT3/PIK3R1	0.425187689482213
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	3/295	75/9376	1.27132203389831	SERPINE1/THBS1/IGFBP3	0.425187689482213
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	8/295	227/9376	1.12010751885313	MT-ATP8/EGFR/PIK3CB/PTK2/MT-ND4L/VEGFA/AKT3/PIK3R1	0.330161264107767
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/295	76/9376	1.25459411239964	EZR/CAMK2G/KCNJ15	0.401646037199945
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	5/295	137/9376	1.15996535939626	PIK3CB/DAB2IP/AKT3/PIK3R1/TNFSF10	0.339941005337981
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/295	18/9376	1.76572504708098	HEXB	0.586067169608654
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/295	169/9376	1.12839233777956	PIK3CB/AKT3/PIK3R1/RRAS2/DAPK1/LAMP2	0.303566047244827
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/295	78/9376	1.22242503259452	ITGB1/PTGS2/JAK1	0.355521608086377
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/295	19/9376	1.67279214986619	HEXB	0.529077398660745
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/295	110/9376	1.15574730354391	PIK3CB/AKT3/PIK3R1/SPDYA	0.29614236438222
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/295	49/9376	1.29726738152888	GALNT15/GALNT17	0.376014088740665
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	10/295	298/9376	1.0665453304516	IL1RL1/IL1RAP/INHBA/CCL21/TNFSF10/PRLR/CSF2RA/LEP/IL1R1/CCL5	0.210407122578843
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	7/295	205/9376	1.08527490698636	PIK3CB/HLA-G/AKT3/PIK3R1/TNFAIP3/JAK1/PLCG2	0.222494687872044
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/295	50/9376	1.27132203389831	THBS1/THBS3	0.346698664667106
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	5/295	144/9376	1.10357815442561	PIK3CB/AKT3/PIK3R1/ATXN2/KCNC3	0.225751853603371
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/295	51/9376	1.24639415088069	TJP2/PLCG2	0.317995423739131
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/295	149/9376	1.0665453304516	DAGLB/MT-ND4L/MGLL/PTGS2/CNR1	0.147574142468341
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/295	54/9376	1.17715003138732	HLA-G/CGA	0.235295365180975
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/295	23/9376	1.38187177597642	CRPPA	0.33047287614361
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/295	24/9376	1.32429378531073	NDST1	0.286696113861401
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	2/295	59/9376	1.07739155415111	GPX3/GGT5	0.107475960372578
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	12/295	388/9376	0.982980954045081	MT-ATP8/PIK3CB/INSR/MT-ND4L/MME/AKT3/PIK3R1/RTN4/AXIN1/PTGS2/SLC39A14/SLC39A11	-0.0617091195768676
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/295	27/9376	1.17715003138732	BAAT	0.16613852260341
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/295	95/9376	1.00367528991971	FLT1/VEGFA/CCL5	0.00648912033883735
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	2/295	62/9376	1.0252597047567	CTBP2/TLE6	0.0359654754912052
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	1/295	28/9376	1.13510895883777	ST3GAL6	0.129042752916327
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/295	63/9376	1.00898574118913	PLOD2/KMT2C	0.0128976084195505
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	2/295	63/9376	1.00898574118913	GGT5/PTGS2	0.0128976084195505
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/295	63/9376	1.00898574118913	TCF7L2/AXIN1	0.0128976084195505
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	4/295	133/9376	0.955881228494966	CREB5/CREB3L2/CAMK2G/AKT3	-0.0923575839247826
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/295	100/9376	0.953491525423729	CCL21/TNFSF10/CCL5	-0.0842716570768329
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	2/295	66/9376	0.963122752953261	GATA3/SMAD3	-0.054185792348232
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/295	101/9376	0.944051015271019	TCF7L2/CREB3L2/CAMK2G	-0.10188863549752
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/295	67/9376	0.948747786491272	ALDOB/HK2	-0.0758801745480848
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/295	31/9376	1.0252597047567	ALDOB	0.0253892149534491
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/295	31/9376	1.0252597047567	UGT2B7	0.0253892149534491
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/295	31/9376	1.0252597047567	IMMP2L	0.0253892149534491
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	3/295	103/9376	0.925719927595853	MSI2/SMG6/NXF1	-0.136618844935453
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/295	68/9376	0.934795613160518	ALDH1A2/UGT2B7	-0.0972596926228
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	9/295	308/9376	0.928725511776359	MT-ATP8/GPX3/CREB5/MT-ND4L/CREB3L2/SLC1A3/RCOR1/TAF4B/PPARG	-0.229236367766849
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	8/295	275/9376	0.924597842835131	MT-ATP8/PIK3CB/CREB5/MT-ND4L/CREB3L2/PIK3R1/C7/CCL5	-0.228736445900752
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/295	70/9376	0.908087167070218	PTGS2/UGT2B7	-0.139114838644064
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/295	73/9376	0.870768516368702	ELL2/ELL	-0.199778182679535
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/295	37/9376	0.859001374255612	GFPT1	-0.154880008025922
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/295	78/9376	0.814950021729683	ITGA5/ITGB1	-0.295781752096873
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/295	39/9376	0.814950021729683	HLA-G	-0.20871202457397
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/295	79/9376	0.804634198669813	SLC1A3/SLC6A2	-0.314282704376057
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	2/295	83/9376	0.76585664692669	JARID2/L3MBTL1	-0.386164831380623
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/295	43/9376	0.739140717382735	CPT1B	-0.309000867605495
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/295	85/9376	0.747836490528415	GDA/ADK	-0.420911005459487
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/295	44/9376	0.722342064714946	TAF4B	-0.332719972434282
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/295	44/9376	0.722342064714946	HLA-G	-0.332719972434282
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/295	45/9376	0.706290018832392	HLA-G	-0.355951375862303
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/295	87/9376	0.730644847067991	TPM1/CACNB2	-0.454914983622356
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	6/295	238/9376	0.801253382709016	EGFR/PIK3CB/PIK3R1/C7/JAK1/PLCG2	-0.559747877717267
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/295	46/9376	0.690935887988209	UGT2B7	-0.37871846539845
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	3/295	128/9376	0.744915254237288	GDA/PDE10A/ADK	-0.523715431694045
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	2/295	89/9376	0.714225861740621	EGFR/PDGFD	-0.488213756800538
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/295	89/9376	0.714225861740621	SLC38A2/SLC38A1	-0.488213756800538
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/295	168/9376	0.756739305891848	CAMK2G/TNFAIP3/TNFSF10/JAK1	-0.573421187143663
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/295	93/9376	0.683506469837799	GATA3/JAK1	-0.552830434532633
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/295	50/9376	0.635661016949153	SAT1	-0.465556877541486
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	1/295	51/9376	0.623197075440346	LPCAT1	-0.486300527967935
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	3/295	138/9376	0.690935887988209	MT-ATP8/MT-ND4L/LHPP	-0.659217838752007
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	3/295	138/9376	0.690935887988209	CAMK2G/YWHAZ/SPDYA	-0.659217838752007
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/295	97/9376	0.655320636030054	CAMK2G/PER2	-0.615007441917601
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	4/295	181/9376	0.702387864032213	CAMK2G/AKT3/JAK1/LAMP2	-0.728691772127803
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	1/295	56/9376	0.567554479418886	SMURF1	-0.584988419164297
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	1/295	57/9376	0.55759738328873	CPT1B	-0.603809952816381
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	2/295	105/9376	0.605391444713479	RRAS2/SMURF1	-0.732871214708385
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	6/295	268/9376	0.711560839868454	MT-ATP8/MT-ND4L/CAMK2G/UBE2G1/SLC39A14/SLC39A11	-0.863455413555043
Organismal Systems	Nervous system	hsa04730	Long-term depression	1/295	60/9376	0.529717514124294	CRH	-0.658642117726494
Human Diseases	Substance dependence	hsa05034	Alcoholism	4/295	191/9376	0.665613630313249	CREB5/CREB3L2/CRH/FOSB	-0.841502630689488
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/295	195/9376	0.651960017383746	PIK3CB/AKT3/PIK3R1/PLCG2	-0.885179318895913
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	3/295	154/9376	0.61915034118424	UGT2B7/PDXK/UGP2	-0.85887741102488
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	3/295	158/9376	0.60347564900236	SMAD3/YWHAZ/WEE1	-0.905961751877324
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/295	66/9376	0.481561376476631	UGT2B7	-0.761770735324587
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	1/295	67/9376	0.474373893245636	CAMK2G	-0.778202500868759
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	2/295	116/9376	0.547983635300994	ALDOB/HK2	-0.882891768614205
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/295	117/9376	0.543300014486455	MBD2/MBD3	-0.895925081776419
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/295	69/9376	0.460623925325473	KCNMA1	-0.810477896389282
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/295	70/9376	0.454043583535109	HLA-G	-0.82633334608703
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8/295	370/9376	0.687201099404489	THRB/PRLR/CGA/CRH/OXTR/KNG1/LEP/CNR1	-1.1064452202963
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/295	73/9376	0.435384258184351	UGT2B7	-0.87283612044573
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/295	75/9376	0.423774011299435	ALDOB	-0.90300147479739
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/295	78/9376	0.407475010864841	ZCCHC7	-0.947085112280124
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/295	79/9376	0.402317099334907	UGT2B7	-0.961485567593696
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/295	82/9376	0.387598181066556	UGT2B7	-1.00385704786052
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	1/295	82/9376	0.387598181066556	HLA-G	-1.00385704786052
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/295	83/9376	0.382928323463345	BAAT	-1.01771575742715
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/295	83/9376	0.382928323463345	CCL5	-1.01771575742715
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/295	187/9376	0.509888516269374	TNFAIP3/JAK1/CCL5	-1.22014477468957
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/295	143/9376	0.444518193670736	C7/ACTN1	-1.20641366665322
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/295	91/9376	0.349264295027007	PDE10A	-1.12425334137625
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/295	93/9376	0.341753234918899	KCNMA1	-1.14978288808301
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/295	102/9376	0.311598537720173	KCNMA1	-1.25990596652384
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	1/295	108/9376	0.29428750784683	NXF1	-1.32946368452181
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/295	115/9376	0.276374355195284	PTGS2	-1.4072256287114
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/295	174/9376	0.365322423533996	UBE2G1/RRBP1	-1.52305810728073
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	8/295	480/9376	0.529717514124294	MT-ATP8/GPX3/MT-ND4L/CAMK2G/ATXN2/UBE2G1/AXIN1/PTGS2	-1.90639041197461
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	3/295	250/9376	0.381396610169492	HEXB/AP3S1/LAMP2	-1.78678326407361
NA	NA	hsa04082	Neuroactive ligand signaling	2/295	199/9376	0.319427646708117	SLC1A3/SLC6A2	-1.74896163757246
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	5/295	368/9376	0.431834929992631	MT-ATP8/GPX3/MT-ND4L/ATXN2/NXF1	-2.00407541022513
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	1/295	183/9376	0.173677873483375	NXF1	-2.03458625031508
Genetic Information Processing	Transcription	hsa03040	Spliceosome	1/295	243/9376	0.130794447931924	RBM25	-2.4742792215967
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/295	449/9376	0.0707863047827564	CAMK2G	-3.63676981262549