category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04518	Integrin signaling	23/187	154/9376	7.48829779845823	FLT1/FN1/AKT3/ITGA5/THBS1/TNC/FBN1/VEGFA/PTK2/LAMA3/PDGFD/PIK3CB/EGFR/FERMT2/VWF/FLNB/ACTN1/ITGB1/LAMB1/COL4A2/PARVA/IGF1R/VCL	11.5811288088001
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	23/187	203/9376	5.68077764020969	FLT1/FN1/AKT3/ITGA5/THBS1/TNC/VEGFA/PTK2/LAMA3/MYL9/PDGFD/PIK3CB/EGFR/VWF/FLNB/ACTN1/ITGB1/LAMB1/COL4A2/PPP1R12B/PARVA/IGF1R/VCL	9.61795295434926
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	24/187	233/9376	5.16453604461683	FN1/TPM1/MYH11/ACTG2/SYNE2/ITGA5/THBS1/DES/FBN1/FMNL2/MYL9/DSP/PDLIM5/ITGB1/LMOD1/PDLIM3/COL4A2/COL27A1/DMD/CSRP1/HSPG2/PDLIM1/VCL/COL5A3	9.18274536564364
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	18/187	232/9376	3.89009773188272	FN1/MYH11/AKT3/ITGA5/PTK2/MYL9/PDGFD/PIK3CB/EGFR/EZR/SSH2/ACTN1/ITGB1/RRAS2/PPP1R12B/LPAR1/TIAM1/VCL	6.35858862237876
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	16/187	204/9376	3.93247352416903	TIMP3/FN1/AKT3/ITGA5/THBS1/VEGFA/PTK2/PIK3CB/EGFR/EZR/ITGB1/RRAS2/PPP1R12B/HSPG2/IGF1R/TIAM1	6.04073071611024
NA	NA	hsa04517	IgSF CAM signaling	19/187	299/9376	3.18609267969882	FOXO1/TRIO/MYH11/AKT3/SORBS1/ITGA5/IL1RAP/PTK2/PARD3/MYL9/PIK3CB/EZR/GRIP1/PTPRF/ACTN1/ITGB1/RASA1/TJP2/VCL	5.48031235442555
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/187	89/9376	5.63359971159046	FN1/ITGA5/THBS1/TNC/LAMA3/VWF/ITGB1/LAMB1/COL4A2/HSPG2	6.26538999743894
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	21/187	362/9376	2.90861819363607	FLT1/FN1/AKT3/ITGA5/THBS1/TNC/INSR/VEGFA/PTK2/LAMA3/PDGFD/PIK3CB/EGFR/VWF/ITGB1/CREB5/LAMB1/COL4A2/JAK2/IGF1R/LPAR1	5.28307630613317
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	11/187	110/9376	5.01390374331551	SERPINE1/FLT1/TF/AKT3/INSR/ALDOB/VEGFA/PIK3CB/EGFR/EGLN3/IGF1R	6.04073054535483
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/187	93/9376	5.39129434765108	TCF7L2/SORBS1/INSR/PARD3/MYL9/EGFR/PTPRF/ACTN1/IGF1R/VCL	6.07102698848689
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/187	62/9376	6.4695532171813	FOXO1/AKT3/INSR/PRKAG2/PIK3CB/IRS2/IGF1R/HSPA1A	6.16384765077843
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	19/187	333/9376	2.86078591960945	FN1/TCF7L2/FOXO1/HLA-G/AKT3/ITGA5/THBS1/TNC/VEGFA/PTK2/LAMA3/PARD3/PIK3CB/EGFR/VWF/ITGB1/CREB5/LAMB1/COL4A2	4.93213071610538
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/187	133/9376	4.1468376824414	FOXO1/FBXO32/AKT3/INSR/HOMER1/PRKAG2/PIK3CB/EGFR/TNFSF10/IRS2/IGF1R	5.21393967076781
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/187	52/9376	6.74948580830934	APOA2/APOC3/APOA1/APOB/APOC2/APOH/LDLR	5.93064408319221
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	9/187	90/9376	5.01390374331551	FOXO1/AKT3/PPARG/INSR/PRKAG2/PIK3CB/CREB5/IRS2/IGF1R	5.45815901858961
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	9/187	101/9376	4.467835018796	SERPINE1/FN1/FOXO1/AKT3/VEGFA/PRKCE/PIK3CB/COL4A2/JAK2	4.99843986193735
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	9/187	106/9376	4.25708808394713	TCF7L2/FOXO1/AKT3/PDGFD/PIK3CB/EGFR/CREB5/IGF1R/ZEB1	4.81077322243808
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	13/187	212/9376	3.07456361618404	FLT1/AKT3/THBS1/INSR/VEGFA/PARD3/PDGFD/PIK3CB/EGFR/ITGB1/IGF1R/LPAR1/TIAM1	4.35837367632135
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	9/187	109/9376	4.13992052200363	FOXO1/AKT3/INSR/PRKAG2/PRKCE/PIK3CB/PTPRF/CREB5/IRS2	4.70364610296711
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/187	93/9376	4.31303547812087	FN1/AKT3/PTK2/LAMA3/PIK3CB/ITGB1/LAMB1/COL4A2	4.58031874184092
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/187	170/9376	3.24429065743945	MYH11/PRKAG2/PRKCE/PARD3/MYL9/EZR/ACTN1/ITGB1/TJP2/CLDN4/TIAM1	4.212504644347
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	9/187	122/9376	3.69878144998685	FOXO1/AKT3/PPARG/INSR/PRKAG2/PIK3CB/CREB5/IRS2/IGF1R	4.28011265302146
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	7/187	78/9376	4.49965720553956	FN1/ITGA5/PTK2/PIK3CB/ITGB1/ARHGAP10/VCL	4.42741623278125
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	13/187	238/9376	2.73868691861771	FLT1/AKT3/INSR/VEGFA/RASGRF2/PDGFD/PIK3CB/EGFR/RASA1/RASAL2/RRAS2/IGF1R/TIAM1	3.87575757040265
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/187	103/9376	3.89429416956544	FN1/PTK2/LAMA3/PIK3CB/ACTN1/LAMB1/COL4A2/VCL	4.21331052195047
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	7/187	80/9376	4.38716577540107	AKT3/VEGFA/PDGFD/PIK3CB/EGFR/JAK2/IGF1R	4.34015964126405
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/187	86/9376	4.08108444223355	TCF7L2/ITGA5/DES/CACNB2/DSP/ITGB1/DMD	4.09465471459182
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	9/187	138/9376	3.26993722390142	FOXO1/AKT3/SORBS1/INSR/PRKAG2/PIK3CB/CBLB/PTPRF/IRS2	3.83209905661334
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	8/187	112/9376	3.58135981665393	AKT3/LAMA3/HLA-DRB5/ITGB1/LAMB1/LDLR/JAK2/HSPA1A	3.92040197285875
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/187	116/9376	3.45786465056242	PTK2/MYL9/PIK3CB/EZR/ACTN1/ITGB1/CLDN4/VCL	3.79973912322264
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	14/187	300/9376	2.33982174688057	FLT1/AKT3/INSR/VEGFA/IL1RAP/RASGRF2/PDGFD/CACNB2/EGFR/RASA1/RRAS2/MAPK8IP3/IGF1R/HSPA1A	3.3645944335085
NA	NA	hsa04519	Cadherin signaling	17/187	404/9376	2.10981098109811	TCF7L2/TEAD1/DES/PTK2/LIMA1/EGFR/KRT6A/DSP/ACTN1/RRAS2/WWTR1/CDH13/PCDH7/LHFPL6/IGF1R/KRT8/VCL	3.25287506537214
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	7/187	99/9376	3.54518446497056	TPM1/ITGA5/DES/PRKAG2/CACNB2/ITGB1/DMD	3.63166180498888
NA	NA	hsa04382	Cornified envelope formation	11/187	217/9376	2.54161019246408	TCHH/LAMA3/PCSK6/KRT6A/DSP/S100A10/COL17A1/COL4A2/CLDN4/KRT8/S100A11	3.27757566267959
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/187	103/9376	3.40750739836976	COL18A1/COL17A1/COL4A2/COL12A1/COL27A1/COL8A1/COL5A3	3.50468047093773
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/187	134/9376	2.99337536914359	MYH11/ACTG2/KCNMA1/PRKCE/MYL9/CALD1/PPP1R12B/ADM	3.31536097007803
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	5/187	59/9376	4.24907096891145	AKT3/INSR/PIK3CB/IRS2/PTGER3	3.57124357003629
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/187	88/9376	3.41857073407876	SERPINE1/CFH/SERPINC1/VWF/TFPI/SERPINE2	3.25170651992015
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	4/187	41/9376	4.89161340811269	THBS1/VEGFA/EGFR/DAPK1	3.56235153725022
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	10/187	216/9376	2.32125173301644	APOA1/APOB/AKT3/PPARG/PTK2/PIK3CB/TNFSF10/LDLR/JAK2/HSPA1A	2.80244452503515
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	11/187	253/9376	2.17995814926761	FOXO1/AKT3/ITGA5/PTK2/PRKCE/MYL9/PIK3CB/EGFR/ACTN1/ITGB1/VCL	2.71412810925353
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	13/187	323/9376	2.01797983477095	TIMP3/TPM1/ITGA5/THBS1/TNC/VEGFA/PRKCE/PIK3CB/EGFR/EZR/SLC7A1/IRS2/ZEB1	2.65592918830481
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/187	47/9376	4.26715212197065	INSR/PRKCE/PIK3CB/IRS2	3.20311885777578
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	10/187	226/9376	2.21854147934314	AKT3/PDE10A/MYL9/PIK3CB/CRH/CREB5/OXTR/RRAS2/PTGER3/TIAM1	2.64518654813028
NA	NA	hsa03272	Virion - Hepatitis viruses	4/187	48/9376	4.17825311942959	EGFR/LDLR/HSPG2/CLDN4	3.14910504444557
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/187	73/9376	3.43418064610651	AKT3/PDGFD/PIK3CB/EGFR/IGF1R	2.97834525397685
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/187	76/9376	3.2986208837602	APOA2/APOC3/APOA1/SORBS1/PPARG	2.87015258540864
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	6/187	105/9376	2.86508785332315	TPM1/ITGA5/DES/CACNB2/ITGB1/DMD	2.74159291055772
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	9/187	201/9376	2.24503152685769	FLT1/FOXO1/ZBTB16/AFF1/PPARG/PTK2/HPGD/IGF1R/ZEB1	2.54535086779349
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	5/187	86/9376	2.91506031588111	AKT3/PTK2/PIK3CB/EGFR/CBLB	2.54504895862763
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	7/187	149/9376	2.35552524853749	AKT3/INSR/PDGFD/PIK3CB/EGFR/RRAS2/LPAR1	2.37926491753044
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/187	59/9376	3.39925677512916	TCF7L2/AKT3/PIK3CB/EGFR	2.63716318080817
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/187	60/9376	3.34260249554367	AKT3/VEGFA/PTK2/PIK3CB	2.59675993913256
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/187	36/9376	4.17825311942959	GALNT15/B4GALT5/GALNT18	2.72545245278902
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/187	122/9376	2.46585429999123	AKT3/PTK2/PIK3CB/CREB5/JAK2/IRS2	2.32476087936241
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	7/187	157/9376	2.2354984842808	SERPINE1/FOXO1/HLA-G/AKT3/PIK3CB/RRAS2/HIPK3	2.22701145735486
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/187	227/9376	1.98789135197531	HLA-G/AKT3/VEGFA/PTK2/PIK3CB/EGFR/CREB5/PTGER3/AKAP13	2.14935233791596
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/187	193/9376	2.07830206976809	AKT3/CCL21/PTK2/PARD3/PIK3CB/JAK2/TIAM1/CCL14	2.15923105037765
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/187	17/9376	5.89871028625354	MYH11/PCDH7	2.88379117483503
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/187	130/9376	2.31410941999177	AKT3/VEGFA/PIK3CB/EGFR/CREB5/COL4A2	2.15227903734922
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	4/187	68/9376	2.94935514312677	TCF7L2/ZBTB16/AKT3/PIK3CB	2.30138645657058
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	5/187	99/9376	2.53227461783612	AKT3/PTK2/PIK3CB/EGFR/IGF1R	2.18636538173814
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	7/187	166/9376	2.11429675922943	AKT3/INSR/KCNMA1/PRKCE/MYL9/CREB5/IRS2	2.06631920445174
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	4/187	70/9376	2.86508785332315	AKT3/PRKAG2/JAK2/IRS2	2.23428775459723
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	4/187	70/9376	2.86508785332315	AKT3/VEGFA/PIK3CB/EGLN3	2.23428775459723
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/187	42/9376	3.58135981665393	TF/SAT1/CP	2.39172700872292
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	6/187	138/9376	2.17995814926761	FN1/AKT3/ITGA5/PTK2/PIK3CB/ITGB1	1.99200068752563
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/187	139/9376	2.16427499711461	AKT3/PIK3CB/EGFR/FKBP5/CREB5/HSPA1A	1.9727398387244
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/187	75/9376	2.67408199643494	ALB/GPX3/TTR/CREB5	2.07641831596054
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	9/187	250/9376	1.80500534759358	HLA-G/PARD3/EGFR/CBLB/RAB11FIP3/ASAP3/LDLR/IGF1R/HSPA1A	1.84035181228224
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/187	76/9376	2.63889670700816	AKT3/PIK3CB/EGFR/IGF1R	2.04639384165967
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/187	109/9376	2.29995584555757	IL1RAP/HLA-DRB5/GATA3/JAK2/RORA	1.94735255371509
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	4/187	77/9376	2.60462532120286	AKT3/VEGFA/PIK3CB/EGFR	2.01684812442401
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	5/187	110/9376	2.2790471560525	TF/THBS1/INHBA/LTBP1/FBN1	1.92490396347511
NA	NA	hsa04081	Hormone signaling	8/187	219/9376	1.83156301125681	INSR/PIK3CB/CRH/OXTR/THRB/JAK2/IRS2/IGF1R	1.77628614887723
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	7/187	184/9376	1.90746338060916	PTK2/PARD3/MYL9/PIK3CB/SSH2/ITGB1/RASA1	1.77339438111419
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/187	50/9376	3.0083422459893	SAT1/AOC1/CKB	2.03117497019158
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	5/187	115/9376	2.17995814926761	EGFR/CREB5/GCM1/GATA3/AKAP13	1.8161800374297
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	3/187	52/9376	2.89263677498972	INSR/LDLR/IGF1R	1.9522711187499
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	6/187	154/9376	1.95346899090215	PRKAG2/MYL9/CACNB2/EGFR/OXTR/PPP1R12B	1.70187120595148
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	6/187	157/9376	1.91614155795497	AKT3/PPARG/INSR/PRKAG2/PIK3CB/IRS2	1.65136402195776
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	2/187	26/9376	3.85684903331962	APOA1/APOB	2.08084856578444
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	4/187	87/9376	2.30524310037495	TCF7L2/AKT3/PIK3CB/EGFR	1.74477273782222
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/187	55/9376	2.734856587263	HEXB/B4GALT5/ACER2	1.84071260326017
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	4/187	90/9376	2.22840166369578	AKT3/PIK3CB/EGFR/JAK2	1.67039671300473
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/187	200/9376	1.75486631016043	MYH11/EZR/ITGB1/TNFSF10/BAIAP2L1/LPAR1/CLDN4	1.53932617491715
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/187	29/9376	3.45786465056242	TEAD1/WWTR1	1.89100708858703
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/187	169/9376	1.78008416922444	AKT3/PIK3CB/RRAS2/DAPK1/IRS2/IGF1R	1.45981580390983
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/187	98/9376	2.04649132380225	AKT3/PRKCE/PIK3CB/ASAP3	1.48557232933499
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	4/187	99/9376	2.02581969426889	AKT3/PDGFD/PIK3CB/EGFR	1.46371717011277
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	7/187	217/9376	1.61738830429533	AKT3/VEGFA/PIK3CB/EGFR/CREB5/UGT2B7/JAK2	1.3126125465913
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/187	66/9376	2.2790471560525	HLA-DRB5/GATA3/RORA	1.48749666045246
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	2/187	34/9376	2.94935514312677	PRKAG2/RORA	1.62436196202409
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	5/187	140/9376	1.79067990832697	SERPINE1/AKT3/PRKAG2/PRKCE/RRAS2	1.34460609226246
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	6/187	180/9376	1.67130124777184	HLA-G/AKT3/ITGA5/PIK3CB/HLA-DRB5/JAK2	1.29725854895025
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	4/187	105/9376	1.9100585688821	AKT3/PIK3CB/CBLB/RRAS2	1.33774401897152
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	5/187	144/9376	1.74093879976233	AKT3/INHBA/PIK3CB/JAK2/IGF1R	1.27816817930723
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/187	36/9376	2.78550207961973	UGT2B7/UGP2	1.53112443833072
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/187	70/9376	2.14881588999236	HLA-G/HLA-DRB5/DMD	1.37622754377133
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	4/187	107/9376	1.8743565395572	FOXO1/AKT3/PRKAG2/CREB5	1.29758652254172
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/187	37/9376	2.71021823963	HBB/APOA1	1.48687522105978
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/187	37/9376	2.71021823963	TCF7L2/PPARG	1.48687522105978
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	7/187	227/9376	1.54613771820302	MT-ATP8/AKT3/VEGFA/PTK2/PIK3CB/EGFR/MT-ND4L	1.18823024323133
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	3/187	71/9376	2.11855087745726	AKT3/PIK3CB/JAK2	1.34958127573099
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/187	71/9376	2.11855087745726	AKT3/PIK3CB/EGFR	1.34958127573099
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/187	148/9376	1.69388639976875	TCF7L2/AKT3/PIK3CB/EGFR/IGF1R	1.21377379184526
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/187	38/9376	2.63889670700816	HEXB/UGP2	1.44407171593166
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/187	38/9376	2.63889670700816	INSR/PIK3CB	1.44407171593166
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	3/187	73/9376	2.06050838766391	AKT3/PIK3CB/EGFR	1.29758657322889
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/187	39/9376	2.57123268887975	HLA-G/HLA-DRB5	1.4026245811178
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/187	115/9376	1.74396651941409	AKT3/PIK3CB/CREB5/JAK2	1.14510598694927
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	6/187	196/9376	1.53486849285169	TCF7L2/HLA-G/AKT3/VEGFA/PIK3CB/JAK2	1.07950840164707
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	5/187	155/9376	1.61738830429533	HLA-G/ITGA5/THBS1/HLA-DRB5/ITGB1	1.1056242401933
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	5/187	155/9376	1.61738830429533	TCF7L2/EGFR/CRH/CREB5/LDLR	1.1056242401933
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	3/187	77/9376	1.95346899090215	AKT3/PIK3CB/CTBP2	1.19841194114768
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	5/187	156/9376	1.60702043054984	AKT3/PIK3CB/EGFR/LDLR/CLDN4	1.09061750174426
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/187	78/9376	1.92842451665981	HLA-DRB5/ITGB1/JAK2	1.174549830042
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	5/187	157/9376	1.59678463162914	THBS1/PPARG/PTK2/MFGE8/JAK2	1.07571658656065
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	5/187	157/9376	1.59678463162914	SERPINE1/TCF7L2/TEAD1/PARD3/WWTR1	1.07571658656065
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	5/187	158/9376	1.58667839978339	AKT3/INSR/PIK3CB/GRB10/IGF1R	1.06091992526728
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/187	43/9376	2.33204825270489	APOA1/APOB	1.24886607345493
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	4/187	119/9376	1.68534579607244	AKT3/PIK3CB/CREB5/DAB2IP	1.073298241188
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	5/187	160/9376	1.5668449197861	HLA-G/HLA-DRB5/PTPRF/ITGB1/CLDN4	1.03163325362311
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	2/187	44/9376	2.2790471560525	HLA-G/HLA-DRB5	1.21310347077775
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	3/187	82/9376	1.83435502804226	HLA-G/HLA-DRB5/HSPA1A	1.08250221902179
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	6/187	205/9376	1.46748402243381	MT-ATP8/AKT3/INSR/PIK3CB/PDK4/MT-ND4L	0.965400838635647
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	5/187	163/9376	1.53800728322562	AKT3/PIK3CB/CREB5/JAK2/HSPG2	0.988447795726694
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/187	45/9376	2.22840166369578	HLA-G/HLA-DRB5	1.17829727644603
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/187	122/9376	1.64390286666082	FOXO1/AKT3/PIK3CB/THRB	1.02119303025638
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	7/187	248/9376	1.41521476625841	TCF7L2/AKT3/AHNAK/MYL9/PIK3CB/S100A10/TNFSF10	0.945329324985998
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/187	46/9376	2.17995814926761	CP/UGT2B7	1.14439779857985
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/187	125/9376	1.60444919786096	AKT3/PRKCE/PIK3CB/ACER2	0.970493849323993
Organismal Systems	Immune system	hsa04611	Platelet activation	4/187	126/9376	1.59171547406841	AKT3/PIK3CB/VWF/ITGB1	0.953892971108736
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/187	48/9376	2.08912655971479	AKT3/PIK3CB	1.07913807187675
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	5/187	170/9376	1.47467757156338	TCF7L2/AKT3/PIK3CB/EGFR/IGF1R	0.89096368518482
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/187	49/9376	2.04649132380225	GALNT15/GALNT18	1.04769530903823
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/187	15/9376	3.34260249554367	HEXB	1.29525543771662
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/187	89/9376	1.69007991347714	PDGFD/EGFR/LPAR1	0.933101704171405
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	5/187	173/9376	1.44910512812587	AKT3/PIK3CB/HLA-DRB5/TNFSF10/JAK2	0.850508523575796
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/187	50/9376	2.0055614973262	HBB/THBS1	1.01699366651088
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/187	90/9376	1.67130124777184	BAAT/UGT2B7/LDLR	0.912844251887756
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/187	16/9376	3.13368983957219	MIF	1.21850038800992
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/187	16/9376	3.13368983957219	HEXB	1.21850038800992
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	5/187	178/9376	1.40839992789761	TCF7L2/DKK1/NOTUM/SFRP1/CTBP2	0.784731834199072
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	3/187	93/9376	1.61738830429533	HLA-DRB5/GATA3/JAK2	0.853548125225991
Human Diseases	Infectious disease: viral	hsa05162	Measles	4/187	136/9376	1.47467757156338	AKT3/PIK3CB/CBLB/HSPA1A	0.795434633036222
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/187	17/9376	2.94935514312677	BAAT	1.14755370901257
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/187	17/9376	2.94935514312677	BAAT	1.14755370901257
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	4/187	137/9376	1.46391350169796	AKT3/PIK3CB/TNFSF10/DAB2IP	0.780291952921401
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/187	54/9376	1.85700138641315	HLA-G/HLA-DRB5	0.900940625742612
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	3/187	95/9376	1.5833380242049	FLT1/VEGFA/HLA-DRB5	0.815186574093816
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/187	18/9376	2.78550207961973	HEXB	1.08162672212672
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/187	98/9376	1.53486849285169	PRKCE/CREB5/LDLR	0.759285638342974
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	4/187	142/9376	1.41236725163817	AKT3/VEGFA/PTK2/PIK3CB	0.706326858782571
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	3/187	99/9376	1.51936477070167	IL1RAP/PRKCE/PIK3CB	0.741068958487405
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/187	19/9376	2.63889670700816	HEXB	1.02007565779835
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/187	100/9376	1.50417112299465	CCL21/TNFSF10/CCL14	0.723052634825877
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	4/187	144/9376	1.39275103980986	TCF7L2/FOXO1/AKT3/PRKAG2	0.677521384540561
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/187	20/9376	2.50695187165775	UGP2	0.962368920710795
Organismal Systems	Nervous system	hsa04730	Long-term depression	2/187	60/9376	1.67130124777184	CRH/IGF1R	0.74413315559072
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	3/187	103/9376	1.46036031358704	SERPINE1/AKT3/PIK3CB	0.670160266886735
Cellular Processes	Cell motility	hsa04814	Motor proteins	5/187	194/9376	1.29224323281328	TPM1/MYH11/ACTG2/KIF21A/MYL9	0.586744462927444
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	4/187	150/9376	1.33704099821747	TCF7L2/AKT3/PIK3CB/EGFR	0.593600082282883
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/187	22/9376	2.2790471560525	AOC1	0.856784359145951
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	4/187	154/9376	1.30231266060143	TPM1/AKT3/CACNB2/CREB5	0.539605605616345
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	2/187	65/9376	1.54273961332785	CREB5/LDLR	0.626357600342553
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/187	65/9376	1.54273961332785	AKT3/PIK3CB	0.626357600342553
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	3/187	110/9376	1.3674282936315	AKT3/PIK3CB/IGF1R	0.552961769515198
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/187	24/9376	2.08912655971479	EXTL3	0.762086093061749
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	6/187	254/9376	1.18438671101941	FLT1/VEGFA/PDGFD/EGFR/OXTR/PTGER3	0.424985152678456
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/187	69/9376	1.45330543284507	AKT3/PIK3CB	0.539116877769575
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/187	26/9376	1.92842451665981	NR5A2	0.676238331601941
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	7/187	308/9376	1.13952357802625	MT-ATP8/PPARG/GPX3/HIP1/CREB5/TAF4B/MT-ND4L	0.355172656243388
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/187	27/9376	1.85700138641315	BAAT	0.636140641355787
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	4/187	168/9376	1.19378660555131	AKT3/PIK3CB/EGFR/JAK2	0.361549742663907
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	3/187	122/9376	1.23292714999562	AKT3/PIK3CB/CBLB	0.369409105703362
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/187	75/9376	1.33704099821747	AKT3/PIK3CB	0.418042905555837
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	2/187	75/9376	1.33704099821747	SERPINE1/THBS1	0.418042905555837
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/187	78/9376	1.28561634443987	ITGA5/ITGB1	0.361333229357182
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/187	224/9376	1.11917494270435	HLA-G/AKT3/PIK3CB/HLA-DRB5/CREB5	0.257527297845541
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/187	31/9376	1.61738830429533	ALDOB	0.491158775298987
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	1/187	31/9376	1.61738830429533	UGT2B7	0.491158775298987
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/187	31/9376	1.61738830429533	IMMP2L	0.491158775298987
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/187	32/9376	1.5668449197861	UGP2	0.458189517045621
Human Diseases	Immune disease	hsa05310	Asthma	1/187	32/9376	1.5668449197861	HLA-DRB5	0.458189517045621
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/187	82/9376	1.22290335202817	UGT2B7/CDA	0.289197481992847
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/187	133/9376	1.13095573157493	HLA-G/PIK3CB/TNFSF10	0.216978234302572
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	5/187	235/9376	1.06678803049266	MT-ATP8/PPARG/PRKAG2/CREB5/MT-ND4L	0.147913573386601
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/187	35/9376	1.43254392666157	ALDOB	0.365712555244754
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	2/187	85/9376	1.17974205725071	ADK/CDA	0.237465354700504
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/187	86/9376	1.16602412635244	KCNMA1/CREB5	0.220640324681335
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/187	36/9376	1.39275103980986	UGP2	0.336796423872414
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	2/187	87/9376	1.15262155018747	TPM1/CACNB2	0.20401557372322
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/187	37/9376	1.355109119815	MIF	0.30873425320239
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/187	37/9376	1.355109119815	UGP2	0.30873425320239
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	2/187	89/9376	1.12671994231809	PLCL1/SLC38A1	0.171346233704614
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	3/187	142/9376	1.05927543872863	AKT3/PPARG/PIK3CB	0.101530454403997
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	2/187	91/9376	1.10195686666275	AKT3/PIK3CB	0.139417900405623
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	6/187	298/9376	1.00951082080178	IL1RL1/CCL21/INHBA/IL1RAP/TNFSF10/CCL14	0.0238014468300661
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	3/187	144/9376	1.0445632798574	AKT3/PIK3CB/RORA	0.0768745897738912
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/187	42/9376	1.19378660555131	AOC1	0.179550582385138
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	4/187	205/9376	0.978322681622538	HLA-G/AKT3/PIK3CB/HLA-DRB5	-0.0447658108870163
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/187	205/9376	0.978322681622538	HLA-G/PIK3CB/ACTN1/CREB5	-0.0447658108870163
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/187	44/9376	1.13952357802625	HEXB	0.132330177161997
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	1/187	44/9376	1.13952357802625	TAF4B	0.132330177161997
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/187	44/9376	1.13952357802625	CREB5	0.132330177161997
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	2/187	99/9376	1.01290984713445	CFH/HLA-DRB5	0.0184207468620375
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	2/187	100/9376	1.0027807486631	ITGA5/HLA-DRB5	0.0039879865306476
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/187	370/9376	0.948576383870502	CRH/OXTR/TAC3/THRB/ADM/LPAR1/PTGER3	-0.143969275639994
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/187	214/9376	0.9371782697786	HLA-G/AKT3/PTK2/PIK3CB	-0.132615397728067
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	1/187	49/9376	1.02324566190112	CREB5	0.0232724059677905
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/187	50/9376	1.0027807486631	HLA-DRB5	0.0028123628301726
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/187	51/9376	0.983118381042256	TJP2	-0.0172443598464615
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/187	109/9376	0.919982338223029	AKT3/PIK3CB	-0.119867608223924
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	5/187	275/9376	0.911618862421001	MT-ATP8/PIK3CB/CREB5/MT-ND4L/HSPA1A	-0.212204061872271
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	7/187	388/9376	0.904570262969293	MT-ATP8/AKT3/INSR/DKK1/PIK3CB/MT-ND4L/IRS2	-0.273867422021914
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	2/187	116/9376	0.864466162640605	HOMER1/SLC38A1	-0.209528716000348
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/187	56/9376	0.895339954163484	HSPA1A	-0.112057078004919
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	2/187	117/9376	0.857077562959916	MORF4L2/GATAD2B	-0.221913446020714
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	2/187	120/9376	0.835650623885918	AKT3/PIK3CB	-0.258475465151939
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/187	59/9376	0.84981419378229	CDA	-0.165077986876172
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/187	59/9376	0.84981419378229	GPX3	-0.165077986876172
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	4/187	238/9376	0.84267289803622	RPS4Y1/PIK3CB/EGFR/VWF	-0.350702417977816
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	3/187	181/9376	0.831033769610305	AKT3/HLA-DRB5/JAK2	-0.327442955422191
Organismal Systems	Digestive system	hsa04978	Mineral absorption	1/187	61/9376	0.821951433330411	TF	-0.199014300947382
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	1/187	62/9376	0.808694152147663	CTBP2	-0.215589839616276
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	1/187	63/9376	0.795857737034207	PLOD2	-0.231916000966852
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/187	63/9376	0.795857737034207	HPGD	-0.231916000966852
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/187	63/9376	0.795857737034207	TCF7L2	-0.231916000966852
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	2/187	128/9376	0.783422459893048	PDE10A/ADK	-0.351938522670304
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/187	66/9376	0.759682385350835	UGT2B7	-0.279482775554414
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/187	67/9376	0.748343842285897	ALDOB	-0.294893882567555
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/187	68/9376	0.737338785781692	UGT2B7	-0.310094834796907
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/187	133/9376	0.753970487716618	AKT3/CREB5	-0.407641945255583
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	3/187	195/9376	0.771369806663924	AKT3/PIK3CB/VWF	-0.460233482921433
Organismal Systems	Endocrine system	hsa04924	Renin secretion	1/187	69/9376	0.726652716422537	KCNMA1	-0.325092362436876
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/187	69/9376	0.726652716422537	CREB5	-0.325092362436876
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/187	70/9376	0.716271963330787	UGT2B7	-0.339892877880483
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/187	71/9376	0.706183625819086	EGFR	-0.3545024952277
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/187	138/9376	0.726652716422537	MT-ATP8/MT-ND4L	-0.461463804591323
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/187	73/9376	0.686836129221302	UGT2B7	-0.383172107519066
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	1/187	73/9376	0.686836129221302	MAP1B	-0.383172107519066
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	2/187	142/9376	0.706183625819086	CBLB/HERC1	-0.503265949974577
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/187	75/9376	0.668520499108734	ALDOB	-0.411144799646517
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/187	143/9376	0.701245278785386	HLA-DRB5/ACTN1	-0.513551135500192
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/187	76/9376	0.659724176752041	EZR	-0.424882389587247
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	1/187	78/9376	0.642808172219937	PIK3CB	-0.451883371327632
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/187	78/9376	0.642808172219937	ZCCHC7	-0.451883371327632
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/187	79/9376	0.634671359913355	UGT2B7	-0.465155506090512
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	1/187	79/9376	0.634671359913355	SLC6A2	-0.465155506090512
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	1/187	83/9376	0.604084788351266	AUTS2	-0.516815561122831
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/187	83/9376	0.604084788351266	BAAT	-0.516815561122831
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	2/187	154/9376	0.651156330300715	UGT2B7/UGP2	-0.622659994718792
Human Diseases	Substance dependence	hsa05032	Morphine addiction	1/187	91/9376	0.550978433331375	PDE10A	-0.614001254754676
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/187	93/9376	0.539129434765108	EGFR	-0.637160121419979
Organismal Systems	Digestive system	hsa04970	Salivary secretion	1/187	93/9376	0.539129434765108	KCNMA1	-0.637160121419979
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	2/187	168/9376	0.596893302775656	TNFSF10/JAK2	-0.752080476526892
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	1/187	98/9376	0.511622830950562	PIK3CB	-0.693287743641055
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	2/187	174/9376	0.576310775093737	RRBP1/HSPA1A	-0.804735656686652
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/187	101/9376	0.496426113199555	TCF7L2	-0.725837237230501
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	1/187	102/9376	0.491559190521128	KCNMA1	-0.736511033492282
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	1/187	103/9376	0.48678677119568	MSI2	-0.74709983513876
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	1/187	105/9376	0.477514642220525	CCL21	-0.768029318407789
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	1/187	105/9376	0.477514642220525	RRAS2	-0.768029318407789
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/187	191/9376	0.525016098776493	CRH/CREB5	-0.946080974956368
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/187	116/9376	0.432233081320302	ALDOB	-0.877740022537514
NA	NA	hsa04082	Neuroactive ligand signaling	2/187	199/9376	0.503909923951307	TAC3/SLC6A2	-1.00904149786407
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	1/187	138/9376	0.363326358211269	IGF1R	-1.07482992762056
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	1/187	149/9376	0.336503606933927	MT-ND4L	-1.16459187509294
Genetic Information Processing	Transcription	hsa03040	Spliceosome	2/187	243/9376	0.412666974758478	RBM25/HSPA1A	-1.32328425534992
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	5/187	480/9376	0.522281639928699	MT-ATP8/GPX3/DKK1/HIP1/MT-ND4L	-1.53273643082272
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	2/187	268/9376	0.374171921142948	MT-ATP8/MT-ND4L	-1.48280228418206
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	3/187	368/9376	0.408742152987677	MT-ATP8/GPX3/MT-ND4L	-1.6506650422713
Genetic Information Processing	Translation	hsa03010	Ribosome	1/187	222/9376	0.225851519969167	RPS4Y1	-1.66520464751583
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/187	250/9376	0.20055614973262	HEXB	-1.82763747229198