category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	107/2577	180/9376	2.16279049713276	HLA-DQA1/HLA-DRB1/CD74/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/NFKBIA/HLA-B/HLA-A/HLA-DPA1/ITGA5/TRAF3/HLA-DOA/STAT1/TLR2/ZC3HAV1/NFKB1/PILRA/IL1B/HLA-DMB/PIK3R1/TBK1/HLA-DQA2/NXF1/BCL2/JAK1/HLA-DMA/TAB2/OAS2/EIF2AK2/C3/NECTIN2/CGAS/BIRC3/IFIH1/TNF/BIRC2/HLA-F/HLA-E/PIK3CB/IFNAR2/SYK/AKT3/BID/HLA-DQB2/IFNAR1/SRC/TICAM1/IRF7/SRSF2/TNFRSF14/TAPBP/MYD88/OAS3/HLA-C/OAS1/PTPN11/STAT2/IFNGR2/SRSF4/PIK3R3/IRAK1/IRF9/SP100/SRSF5/RHEB/TRAF6/POU2F1/CASP3/SRPK1/POU2F2/IFNGR1/TAP2/SOCS3/APAF1/IL6/TYK2/CASP8/EIF2S1/RELA/HCFC1/CHUK/B2M/CYCS/TAP1/PILRB/PPP1CB/PDIA3/TAPBPL/CASP9/SRSF3/AKT2/TRAF5/SRSF7/IKBKE/EIF2B5/HLA-G/JAK2/ITGB3/FAS/TNFSF14/NECTIN1/TRAF2/TLR3/CFP/HLA-DOB	9.69747284143851
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	117/2577	205/9376	2.07651551719242	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/CDKN1A/NFKBIA/HLA-B/HLA-A/RELB/NCOR2/HLA-DPA1/MAP2K3/CD44/TNFAIP3/TRAF3/HLA-DOA/STAT1/TLR2/NFKB1/GADD45B/BCL2L11/HLA-DMB/PIK3R1/TBK1/CD58/RIPK1/STAT3/HLA-DQA2/PLCG2/BCL2/JAK1/NFKB2/HLA-DMA/TAB2/OAS2/EIF2AK2/ICAM1/TNF/HES1/ENTPD1/NFKBIE/HLA-F/HLA-E/PIK3CB/IFNAR2/SIN3A/SYK/MDM2/AKT3/BID/HLA-DQB2/IFNAR1/PSMD12/USP7/IRF7/TAPBP/RUNX3/MYD88/BTK/NFKBIB/OAS3/HLA-C/OAS1/PSMD1/SNW1/LYN/GADD45A/PSMD14/STAT2/RB1/SAP30/PIK3R3/GADD45G/IRAK1/ISG15/IRF9/MAP2K4/MAPK8/PSMC1/VIM/MAPK13/TRAF6/E2F3/CASP3/TAP2/APAF1/CDKN1B/IL6/TYK2/MAP3K14/CASP8/MAPK14/RELA/CD40/CHUK/B2M/CYCS/TAP1/CCND3/PDIA3/DDB2/TAPBPL/BLNK/CASP9/AKT2/TRAF5/MAP2K7/IKBKE/RAC1/HLA-G/FAS/TRAF2/CXCL10/HLA-DOB/CCNE1	9.59420966376142
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	135/2577	250/9376	1.96470314318976	PSAP/LITAF/RAB7A/ARL8B/SLC17A5/CLN8/MANBA/ATP6V1H/BLOC1S6/IDS/GNS/CTSS/CTSH/LAMP2/AP5Z1/ATP6V1C1/GGA1/NPC1/OSBPL1A/GLA/ARSG/GGA2/ATP6V1A/HEXB/IGF2R/GNPTAB/GM2A/VPS35/TLR7/DMXL1/PLEKHM1/CTSA/OSBP/PPT1/TPP1/BORCS5/RRAGD/VPS26A/SLC36A4/RPTOR/MAN2B1/TPCN1/AP1G1/GALC/HGSNAT/ARSB/CTSD/ATP6V1B2/LAPTM5/ATP6V1E1/HEXA/DMXL2/M6PR/OSTM1/RRAGC/SPG11/TFE3/GUSB/CLCN7/SLC11A2/AP3D1/BLOC1S2/LIPA/TFEB/VPS13C/PIKFYVE/DNASE2/NCOA7/GPR155/AP3B1/GNPTG/ATP6V1D/FUCA2/ARL8A/LAMTOR3/ATP6V0A1/OSBPL3/CLN3/NEU1/VPS41/CTBS/SLC15A4/ATP6AP1/ATP6V0D1/AP1B1/VAMP7/GGA3/AP5B1/VPS13A/AP3S2/AP1S3/AP3S1/DTNBP1/SNAP29/AP2A2/SLC11A1/ACP5/STX17/ZFYVE26/ENTPD4/TPCN2/AGA/TLR8/VPS11/CTSB/WDR7/SLC29A3/AP1M1/OSBPL2/CTSL/MITF/SLC29A1/SUMF1/ASAH1/ATP6V0A2/VPS18/AP5M1/TMEM175/BLOC1S5/CD68/SLC2A6/SGSH/LAMP3/GALNS/MEAK7/AP4B1/CTSZ/ABCB9/BLOC1S4/TLR3/SLC36A3/CTSV/MCOLN2/OSBPL7/IDUA	9.51795818622551
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	104/2577	181/9376	2.0905374144847	HLA-DQA1/HLA-DRB1/CD74/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/ITGAX/IRAK2/HLA-DPA1/MALT1/CIITA/HLA-DOA/STAT1/TLR2/NFKB1/RAB7A/IL1B/PLK3/HLA-DMB/ATP6V1H/HLA-DQA2/HSPA9/BCL2/JAK1/HLA-DMA/FCGR2B/CTSS/IL10RA/EP300/C3/SPHK1/TNF/LAMP2/TGFB1/IL1A/CREBBP/TLR1/RIPK2/SYK/RAB5A/AKT3/BID/HLA-DQB2/MAPK1/HSPD1/SRC/VDR/RAF1/FCGR2A/MYD88/CTSD/IFNGR2/IRAK1/CLEC7A/IL10/MAPK8/NOD2/IL18/MAPK13/TRAF6/TLR4/CASP3/ATP6V0A1/BCL10/IFNGR1/APAF1/IL6/CASP8/ITGAM/FCGR1A/MAPK14/ATP6AP1/ATP6V0D1/NFYC/RELA/RHOA/PPP3R1/CYCS/CREB1/PIK3C3/KSR1/CAMK2G/CASP10/RAB5B/CASP9/PPP3CA/FCGR3A/CAMK2D/CEBPG/TLR6/CLEC4E/CEBPB/AKT2/ATP6V0A2/ITGB2/RFX5/IL23A/JAK2/LSP1/CALM1/TGFB2/FCGR3B/HLA-DOB	9.12061907345725
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	87/2577	142/9376	2.22912328452672	NFKBIA/RELB/MAP2K1/LCP2/FOSL1/FOSL2/STAT1/SQSTM1/NFKB1/CYLD/GAB2/IL1B/ITPR1/PIK3R1/PLCG2/JAK1/NFKB2/TAB2/GRB2/FCGR2B/LILRB1/TNF/TGFB1/IL1A/ATP2A2/LILRB2/PIK3CB/IFNAR2/SYK/AKT3/MAPK1/IFNAR1/NFATC1/SIRPA/FCGR2A/BTK/OSCAR/STAT2/IFNGR2/PIK3R3/IRF9/MAPK8/SOCS1/MAPK13/TRAF6/PPARG/NCF1/IFNGR1/SOCS3/LILRB3/TEC1/LILRB4/TYK2/FOSB/MAP3K14/FCGR1A/MAPK14/RELA/CHUK/PPP3R1/LILRA6/CREB1/ACP5/TGFBR2/TYROBP/SPI1/BLNK/FYN/PPP3CA/FCGR3A/MITF/AKT2/ATP2A3/TREM2/MAP2K7/JUNB/RAC1/JUND/LILRA2/ITGB3/TRAF2/LILRA5/LILRA1/TGFB2/ATP2A1/FCGR3B/LILRA4	9.08583843729936
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	93/2577	163/9376	2.07586221673083	CDKN1A/NFKBIA/MAP2K3/MAP2K1/TRAF3/PTK2B/STAT1/TLR2/NFKB1/CXCL8/PIK3R1/TBK1/STAT4/STAT3/BCL2/JAK1/TAB2/GRB2/CREB5/SMAD3/EP300/IFIH1/TNF/TGFB1/CREBBP/ATF4/PIK3CB/AKT3/BID/MAPK1/IFNAR1/SRC/TICAM1/NFATC1/IRF7/RAF1/EGR3/MYD88/KRAS/YWHAQ/BRAF/DDX3X/SOS2/STAT5A/STAT2/RB1/PIK3R3/YWHAZ/PRKCB/IRAK1/MAP2K4/MAPK8/STAT5B/STAT6/MAPK13/DDB1/TRAF6/TLR4/E2F3/CASP3/SLC10A1/APAF1/IL6/TYK2/CASP8/MAPK14/ATP6AP1/NRAS/RELA/NFATC3/CHUK/MAP3K1/CYCS/CREB1/CASP10/TGFBR2/DDB2/TICAM2/CASP9/PRKCG/CREB3/YWHAB/ARAF/AKT2/MAP2K7/EGR2/IKBKE/JAK2/FAS/ELK1/TGFB2/TLR3/CCNE1	8.53041675614685
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	106/2577	196/9376	1.96767321596858	CDKN1A/NFKBIA/VEGFA/HLA-B/HLA-A/CXCL3/MAP2K1/TRAF3/CXCL2/MAPKAPK2/STAT1/PIK3R5/PTGS2/NFKB1/CXCL8/ITPR1/PIK3R1/TBK1/UBC/STAT3/PLCG2/JAK1/EIF2AK2/EP300/C3/HIF1A/ICAM1/GNB4/CXCL1/MAP1LC3B/CLEC2B/CREBBP/HLA-F/HCK/HLA-E/PIK3CB/IFNAR2/SYK/AKT3/BID/MAPK1/PREX1/IFNAR1/SRC/TICAM1/NFATC1/IRF7/GNB1/RAF1/GNG7/ATG3/KRAS/CD86/HLA-C/LYN/STAT2/RB1/PDGFB/PIK3R3/IRF9/TCF7/MAP2K4/MAPK8/PIK3CG/BECN1/MAPK13/E2F3/CASP3/GSK3B/IFNGR1/IL6/ZFP36/TYK2/PIK3R6/CASP8/MAPK14/NRAS/RELA/NFATC3/CHUK/PPP3R1/CYCS/CREB1/ATG14/PIK3C3/CASP9/PPP3CA/CCR5/RCAN1/AKT2/MAP2K7/IKBKE/RAC1/HLA-G/JAK2/CTNNB1/FAS/CALM1/GNB5/TRAF2/CSF2/GNG4/GNGT2/TLR3/MAP1LC3B2/CCR3	8.42860579554902
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	95/2577	169/9376	2.04522023452802	MAP2K1/ERN1/C9orf72/SQSTM1/EIF2AK3/CFLAR/IRS2/RAB7A/ITPR1/GABARAPL1/PIK3R1/TBK1/UBC/BCL2/DDIT4/HIF1A/PPP2CA/MRAS/LAMP2/MAP1LC3B/PIK3CB/EIF2AK4/AKT3/VMP1/TANK/MAPK1/WDR45B/MTMR14/PLEKHM1/RAF1/RRAGD/ATG16L1/RAB8A/WIPI2/RB1CC1/RPTOR/ATG3/KRAS/MTMR3/CTSD/PDPK1/ATG16L2/PIK3R3/NRBF2/RUBCN/RRAGC/ATG5/TAX1BP1/RHEB/MAPK8/CAMKK2/ATG4B/BECN1/TP53INP2/TRAF6/ATG2A/EPG5/ATG101/CALCOCO2/RAB1A/WIPI1/RPS6KB1/UVRAG/VPS41/ATG12/ZFYVE1/EIF2S1/NRAS/BIRC6/SNAP29/ATG14/RAB7B/PIK3C3/ATG13/STX17/DAPK1/PRKCD/ATG7/VPS11/CTSB/PRKAA1/OPTN/PTEN/CTSL/ULK1/AKT2/DAPK3/VPS18/ATG4A/PIK3R4/SMCR8/BNIP3/RAB33B/MAP1LC3B2/DAPK2	8.44135988763672
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	95/2577	173/9376	1.99793190540598	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/NFKBIA/MX1/HLA-DPA1/MX2/MAP2K1/CIITA/TRAF3/HLA-DOA/DNAJB1/STAT1/NFKB1/CXCL8/IL1B/HNRNPUL1/HLA-DMB/PIK3R1/TBK1/HLA-DQA2/NXF1/JAK1/HLA-DMA/OAS2/TRIM25/EIF2AK2/ADAR/EP300/NLRP3/ICAM1/IFIH1/TNF/NUP98/IL1A/CREBBP/PIK3CB/IFNAR2/TNFRSF10B/AKT3/BID/HLA-DQB2/MAPK1/IFNAR1/TICAM1/DNAJC3/TLR7/IRF7/RAF1/MYD88/NFKBIB/OAS3/OAS1/STAT2/IFNGR2/PIK3R3/PRKCB/NXT1/IRF9/XPO1/IL18/RSAD2/KPNA1/KPNA6/TLR4/CALCOCO2/CASP3/IFNGR1/SOCS3/APAF1/IL6/TYK2/CASP8/KPNA2/EIF2S1/RELA/CHUK/RAB11A/CYCS/CCND3/TNFRSF10A/NXT2/CASP9/TNFSF10/AKT2/IKBKE/JAK2/FAS/BCL2L2-PABPN1/CXCL10/TLR3/HLA-DOB	8.15604428756614
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	69/2577	112/9376	2.24147680026609	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/NFKBIA/HLA-DPA1/MAP2K3/CIITA/HLA-DOA/STAT1/PIK3R5/TLR2/NFKB1/HLA-DMB/PPIF/STAT3/HLA-DQA2/BCL2/JAK1/HLA-DMA/TAB2/IL10RA/BIRC3/TNF/BIRC2/TGFB1/HSPA1B/AKT3/HLA-DQB2/LDLR/HSPA8/MAPK1/HSPA6/GNAI3/ALOX5/MYD88/NFKBIB/HSPA1A/PDPK1/IFNGR2/IRAK1/IL10/MAPK8/SOCS1/PIK3CG/MAPK13/TRAF6/TLR4/CASP3/IFNGR1/TYK2/PIK3R6/CASP8/MAPK14/RELA/CD40/CHUK/CYCS/CASP9/CCR5/AKT2/LAMB3/ITGB1/JAK2/TGFB2/HSPA1L/HLA-DOB	8.13708163846363
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	111/2577	216/9376	1.86970206527832	SOD2/NFKBIA/CXCL3/MAP2K3/ERN1/TRAF3/CXCL2/EIF2AK3/NFE2L2/TLR2/ABCG1/NFKB1/CXCL8/IL1B/ITPR1/PIK3R1/TBK1/STAT3/BCL2/TAB2/OLR1/DDIT3/NLRP3/ICAM1/TNF/HSPA1B/CXCL1/ATF4/ERO1A/HSP90AA1/ATF6/PIK3CB/TNFRSF10B/HSP90AB1/AKT3/BID/TANK/LDLR/HSPA8/MAPK1/HSPD1/HSPA6/SRC/TICAM1/NFATC1/IRF7/HSPA4/ABCA1/MYD88/KRAS/HSPA5/RXRA/HSPA1A/PDPK1/LYN/PIK3R3/IRAK1/MAP2K4/MAPK8/IL18/XBP1/VAV2/MAPK13/VAV1/RAP1A/TRAF6/TLR4/POU2F1/PPARG/CASP3/GSK3B/POU2F2/NCF1/APAF1/IL6/RAP1B/CASP8/PLCB2/MAPK14/EIF2S1/NRAS/RELA/CD40/NFATC3/RHOA/CHUK/PPP3R1/CYCS/MAP3K5/VAV3/CAMK2G/TNFRSF10A/TICAM2/CASP9/PPP3CA/CAMK2D/TLR6/CDC42/TNFSF10/AKT2/MAP2K7/IKBKE/RAC1/JAK2/FAS/APOA1/CALM1/TRAF2/HSPA1L/APOB/CCL3L1	7.96104295127568
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	52/2577	78/9376	2.42555943603673	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/NFKBIA/HLA-DPA1/HLA-DOA/STAT1/PTGS2/TLR2/NFKB1/IL1B/HLA-DMB/HLA-DQA2/JAK1/HLA-DMA/TAB2/C3/ITGA4/TNF/TGFB1/IL1A/HLA-DQB2/MAPK1/FCGR2A/MYD88/MARCKSL1/NFKBIB/IFNGR2/PRKCB/IRAK1/IL10/MAPK13/TRAF6/TLR4/NCF1/IFNGR1/ITGAM/FCGR1A/MAPK14/RELA/FCGR3A/ITGB2/ITGB1/JAK2/ELK1/EEF1A1/TGFB2/FCGR3B/HLA-DOB	7.78319992912444
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	41/2577	56/9376	2.66378402350463	NFKBIA/CXCL3/CXCL2/TLR2/NFKB1/CXCL8/IL1B/NFKB2/CLK1/C3/TNF/NAIP/HSPA1B/CXCL1/BCL2L13/HSPA8/HSPD1/HSPA6/MYD88/VCP/HSPA1A/TLR5/HSF1/SAR1B/IL18/SAR1A/TLR4/RAB1A/CASP3/APAF1/HBS1L/IL6/CASP8/ITGAM/RELA/CYCS/CASP9/ITGB2/BNIP3/EEF1A1/HSPA1L	7.6878222574182
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	69/2577	119/9376	2.10962522377985	NFKBIA/CXCL3/MAP2K3/TNFAIP3/MAP2K1/IRF1/TRAF3/CXCL2/TNFRSF1B/BCL3/PTGS2/NFKB1/CYLD/CFLAR/IL1B/PIK3R1/TRAF1/RIPK1/TAB2/CREB5/ADAM17/BIRC3/ICAM1/TNF/BIRC2/MAP3K8/CXCL1/CCL20/ATF4/PIK3CB/AKT3/MAPK1/IL15/RHBDF2/PIK3R3/DNM1L/MAP2K4/MAPK8/NOD2/ITCH/MAPK13/CASP3/SOCS3/IL6/RPS6KA5/MAP3K14/CASP8/MAPK14/MLKL/RELA/CHUK/MAP3K5/FRMD8/CREB1/TAB3/CASP10/JAG1/CREB3/CEBPB/AKT2/TRAF5/MAP2K7/JUNB/FAS/CXCL5/TRAF2/CSF2/CXCL10/LIF	7.4995463952683
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	55/2577	91/9376	2.19899619201133	NFKBIA/MAP2K1/MALT1/NFKB1/PIK3R1/CD72/PLCG2/GRB2/FCGR2B/LILRB1/PIK3AP1/NFKBIE/LILRB2/PIK3CB/SYK/AKT3/MAPK1/INPP5D/NFATC1/CD22/RAF1/BTK/KRAS/NFKBIB/SOS2/LYN/PIK3R3/PRKCB/INPPL1/VAV2/VAV1/DAPP1/BCL10/GSK3B/LILRB3/LILRB4/NRAS/RELA/NFATC3/CHUK/RASGRP3/PPP3R1/LILRA6/VAV3/BLNK/PPP3CA/AKT2/CARD11/RAC1/IFITM1/LILRA2/LILRA5/LILRA1/LILRA4/CD81	7.07567493687259
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	60/2577	105/9376	2.07905094517434	NFKBIA/RELB/IRF1/MALT1/MAPKAPK2/BCL3/STAT1/PTGS2/NFKB1/CYLD/IL1B/ITPR1/PLK3/PIK3R1/PLCG2/PAK1/NFKB2/NLRP3/MRAS/TNF/PIK3CB/SYK/MDM2/AKT3/MAPK1/SRC/NFATC1/RAF1/EGR3/KRAS/PTPN11/STAT2/PIK3R3/IRF9/CLEC7A/IL10/MAPK8/MAPK13/BCL10/IL6/MAP3K14/CASP8/MAPK14/NRAS/RELA/NFATC3/RHOA/CHUK/PPP3R1/KSR1/PRKCD/PPP3CA/CLEC4E/AKT2/EGR2/IKBKE/IL23A/LSP1/CBLB/CALM1	6.84531811407737
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	61/2577	109/9376	2.03613475593909	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/NFKBIA/HLA-DPA1/IL6R/HLA-DOA/STAT1/NFKB1/IL1B/HLA-DMB/RARA/STAT3/HLA-DQA2/JAK1/HLA-DMA/AHR/SMAD3/HIF1A/TGFB1/NFKBIE/HSP90AA1/IL4R/HSP90AB1/HLA-DQB2/MAPK1/IL1RAP/NFATC1/RUNX1/NFKBIB/RXRA/STAT5A/IFNGR2/IRF4/SMAD2/MAPK8/STAT5B/STAT6/MAPK13/CD4/IFNGR1/IL6/TYK2/MAPK14/RELA/NFATC3/CHUK/PPP3R1/TGFBR2/IL2RG/PPP3CA/IL2RA/IL21R/IL12RB1/IL23A/JAK2/HLA-DOB/IL27	6.69854125114695
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	79/2577	155/9376	1.85437931077647	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-B/HLA-A/HLA-DPA1/DYNC1H1/ITGA5/HLA-DOA/ITGAV/TLR2/RAB7A/MSR1/HLA-DMB/ATP6V1H/HLA-DQA2/HLA-DMA/OLR1/FCGR2B/CTSS/C3/LAMP2/TUBB4B/HLA-F/ATP6V1C1/HLA-E/RAB5A/ATP6V1A/HLA-DQB2/DYNC1LI1/FCGR2A/TUBA1C/TUBB6/HLA-C/VAMP3/TFRC/ATP6V1B2/ATP6V1E1/M6PR/CANX/CLEC7A/PIKFYVE/STX12/TUBA4A/ATP6V1D/TLR4/ATP6V0A1/NCF1/TAP2/ITGAM/FCGR1A/ATP6AP1/ATP6V0D1/TAP1/THBS1/RAB7B/PIK3C3/SCARB1/RAB5B/FCGR3A/TUBA1A/TLR6/CTSL/ATP6V0A2/ITGB2/TUBB3/RAC1/ITGB1/HLA-G/ITGB3/FCAR/THBS3/MPO/FCGR3B/SEC61A2/HLA-DOB	6.60310020772532
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	59/2577	105/9376	2.04440009608811	NFKBIA/CXCL3/RELB/TNFAIP3/MALT1/TRAF3/CXCL2/PTGS2/NFKB1/CYLD/GADD45B/CFLAR/CXCL8/IL1B/TNFSF13B/TRAF1/RIPK1/PLCG2/BCL2/NFKB2/TAB2/TRIM25/PLAU/BIRC3/BCL2A1/ICAM1/TNF/BIRC2/CXCL1/SYK/TICAM1/MYD88/BTK/CCL21/LYN/GADD45A/GADD45G/PRKCB/IRAK1/ERC1/TRAF6/CSNK2B/TLR4/BCL10/MAP3K14/RELA/CD40/CHUK/TAB3/BLNK/TICAM2/TRAF5/CARD11/PPP1R13L/CXCL12/TNFSF14/TRAF2/PIDD1/CCL4L2	6.62549894244422
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	79/2577	156/9376	1.84249226391252	CDKN1A/NFKBIA/MX1/MX2/MAP2K1/TRAF3/STAT1/NFKB1/CFLAR/PIK3R1/TBK1/RIPK1/STAT3/JAK1/OAS2/GRB2/EIF2AK2/PPP2CA/TNF/PIK3CB/IFNAR2/AKT3/BID/LDLR/MAPK1/IFNAR1/TICAM1/IRF7/RAF1/YWHAG/KRAS/YWHAQ/PPP2R2D/OAS3/PPP2R2A/BRAF/SOS2/OAS1/RXRA/STAT2/RB1/PIK3R3/YWHAZ/IRF9/RSAD2/TRAF6/E2F3/CASP3/GSK3B/SOCS3/APAF1/TYK2/CASP8/PIAS1/EIF2S1/NRAS/RELA/CHUK/CYCS/PPP2R1A/IFIT1/SCARB1/CASP9/YWHAH/YWHAB/ARAF/AKT2/PPP2R1B/IKBKE/CTNNB1/CLDN1/FAS/TRAF2/CXCL10/TLR3/CLDN12/CD81/CLDN6/CLDN4	6.53255518562783
Human Diseases	Infectious disease: viral	hsa05162	Measles	71/2577	136/9376	1.899427058367	NFKBIA/MX1/MX2/TNFAIP3/TRAF3/STAT1/TLR2/NFKB1/IL1B/PIK3R1/TBK1/STAT3/BCL2/JAK1/TAB2/OAS2/FCGR2B/EIF2AK2/ADAR/IFIH1/HSPA1B/IL1A/PIK3CB/IFNAR2/AKT3/BID/MSN/HSPA8/IFNAR1/HSPA6/TLR7/CD46/IRF7/MYD88/NFKBIB/OAS3/OAS1/HSPA1A/STAT5A/STAT2/EIF3H/PIK3R3/IRAK1/IRF9/MAPK8/STAT5B/TRAF6/CSNK2B/TLR4/CASP3/GSK3B/APAF1/CDKN1B/IL6/TYK2/CASP8/EIF2S1/RELA/CHUK/CYCS/CCND3/IL2RG/CASP9/AKT2/IL2RA/IKBKE/FAS/CBLB/SLAMF1/HSPA1L/CCNE1	6.50458726029815
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	105/2577	227/9376	1.68293220782285	CDKN1A/NFKBIA/VEGFA/HLA-B/HLA-A/IL6R/MAP2K1/AKAP13/PTK2B/CXCR4/GNA13/ITGAV/PTGS2/NFKB1/CXCL8/IL1B/ITPR1/GNA12/PIK3R1/TBK1/RIPK1/STAT3/JAK1/GRB2/CREB5/IL10RA/CGAS/TNF/PTGER4/GNB4/HLA-F/ATF4/HLA-E/PIK3CB/MDM2/AKT3/BID/MAPK1/SRC/GNAI3/CRK/NFATC1/GNB1/RAF1/TAPBP/GNG7/KRAS/HLA-C/SOS2/RB1/PIK3R3/PRKCB/RHEB/MAPK13/E2F3/RPS6KB1/CASP3/GSK3B/GNAQ/TAP2/ROCK1/IL6/CASP8/PLCB2/MAPK14/NRAS/RELA/NFATC3/RHOA/CHUK/ARHGEF11/B2M/PPP3R1/ADCY3/CYCS/TAP1/CREB1/PDIA3/TAPBPL/CASP9/PPP3CA/CCR5/PRKCG/CREB3/AKT2/TRAF5/PTGER2/SP1/RAC1/HLA-G/GNAS/CTNNB1/ITGB3/FAS/ELK1/CXCL12/CALM1/GNB5/TRAF2/GNG4/GNGT2/CCL3L1/CCL4L2/PTGER3/CCR3	6.41245066284303
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	112/2577	248/9376	1.64312090828295	NFKBIA/DYNC1H1/MAP2K3/MAP2K1/RALA/TLR2/CYTH1/PLEKHM2/NFKB1/CXCL8/RAB7A/IL1B/ARL8B/KPNA4/RIPK1/PAK1/BCL2/SNX9/TAB2/NLRP3/ABI1/BIRC3/TNF/BIRC2/TUBB4B/NAIP/HSP90AA1/PIK3CB/TNFRSF10B/RIPK2/RAB5A/AHNAK/HSP90AB1/DNM2/AKT3/MAPK1/DYNC1LI1/PLEKHM1/RAF1/MYD88/PTPRC/TUBA1C/TUBB6/ACBD3/GCC2/M6PR/KIF5B/IRAK1/TCF7/TLR5/NCKAP1L/KPNA3/MAP2K4/MAPK8/CYFIP1/IL18/KPNA1/RHOB/PIK3CG/PIK3C2A/MAPK13/CASP4/TUBA4A/TRAF6/TLR4/ARL8A/CASP3/ACTR3/VPS41/IL6/WASL/CYTH4/DYNLT3/CASP8/MAPK14/MLKL/RELA/RHOA/CHUK/FLNA/CYCS/RAB7B/PIK3C3/ACTR2/TAB3/ELMO1/RAB5B/TNFRSF10A/TXN/CYTH3/VPS11/TUBA1A/TLR6/RHOH/CDC42/TNFSF10/AKT2/FHOD1/VPS18/MAP2K7/TUBB3/RAC1/FYCO1/CTNNB1/EXOC4/MYL5/KLC4/ARPC5/TRAF2/CYFIP2/ANXA2/KLC2	6.31903819749832
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	71/2577	138/9376	1.87189912998487	NFKBIA/MAP2K3/MAP2K1/ITGA5/LCP2/PTK2B/NFKB1/CXCL8/IL1B/PIK3R1/TBK1/TAB2/ITGA4/NLRP3/TNF/RPS6KA3/PIK3CB/AKT3/MAPK1/SRC/TICAM1/CRK/NFATC1/PIP5K1A/ARHGEF7/FCGR2A/MYD88/WAS/BAIAP2/WIPF1/WIPF2/PIK3R3/IRAK1/MAP2K4/IL10/MAPK8/IL18/FYB1/VAV2/MAPK13/VAV1/TRAF6/TLR4/PIP5K1C/GSK3B/CD4/ACTR3/GNAQ/ROCK1/IL6/RPS6KA1/WASL/MAPK14/RELA/NFATC3/RHOA/CHUK/SKAP2/VAV3/ACTR2/ELMO1/RPS6KA2/CDC42/AKT2/MAP2K7/RAC1/ITGB1/PIP5K1B/ARPC5/MEFV/TRAF2	6.35238973722435
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	112/2577	250/9376	1.62997594101669	HLA-B/HLA-A/CXCR4/AGAP3/CHMP1B/CYTH1/RAB7A/CHMP4B/EHD1/ARFGAP3/RAB31/SMAD3/ZFYVE16/SMAP2/HSPA1B/CHMP2B/HLA-F/HLA-E/VPS37B/RAB5A/MDM2/DNM2/SPART/LDLR/HSPA8/IQSEC1/HSPA6/IGF2R/SRC/WASHC2A/IST1/VPS35/ARFGEF2/USP8/WASHC2C/PIP5K1A/VPS26A/RAB8A/SMURF1/SMURF2/RUFY1/SMAP1/ARAP1/HLA-C/TFRC/HSPA1A/EHD4/WIPF1/SNX1/VPS4B/WIPF2/SMAD2/SH3KBP1/KIF5B/RAB22A/PDCD6IP/GBF1/ARRB2/RAB35/SH3GL1/CHMP3/ITCH/WASHC5/RAB10/SNX32/RAB11FIP1/VPS36/RABEP1/SPG21/TRAF6/ARF4/PIP5K1C/ARFGEF1/STAM/ACTR3/CBL/WASL/CYTH4/RHOA/RAB11A/ACAP2/STAM2/GRK6/AP2A2/ACTR2/IQSEC2/TGFBR2/RAB5B/IL2RG/GRK3/PSD/MVB12B/CYTH3/CAPZB/VPS37C/NEDD4L/CCR5/PLD2/CDC42/IL2RA/RAB11FIP3/PSD4/HLA-G/PIP5K1B/CBLB/ARPC5/PSD3/HSPA1L/ASAP1/GRK4/ACAP1/AGAP9	6.21547126414355
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	94/2577	200/9376	1.7100194024059	NFKBIA/GNA13/CYTH1/NFKB1/CXCL8/IL1B/GNA12/RIPK1/PAK1/TAB2/SEC24A/EZR/NLRP3/ABI1/TNF/TUBB4B/NAIP/MYH9/TNFRSF10B/MAPK1/SRC/ARHGEF2/FCGR2A/MYD88/MYO1G/NFKBIB/BAIAP2/TUBA1C/TUBB6/HCLS1/PAK2/SEC24D/PTPN11/WIPF1/WIPF2/MYO5A/IRAK1/TLR5/NCKAP1L/MAPK8/CYFIP1/IL18/MAPK13/MYO1F/CASP4/TUBA4A/TRAF6/NCL/TLR4/RAB1A/SEC24B/CASP3/MYH11/ACTR3/ROCK1/IL6/WASL/TMED10/CYTH4/CASP8/SEC24C/MAPK14/RELA/RHOA/CHUK/ARHGEF11/CYCS/ACTR2/TAB3/ABL1/TNFRSF10A/FYN/CASP9/MYO1D/CYTH3/TUBA1A/CDC42/TNFSF10/TUBB3/RAC1/ITGB1/ABCF2/CLDN1/MYO5C/FAS/LPAR2/ARPC5/MYO1E/TMBIM6/TRAF2/CYFIP2/CLDN12/CLDN6/CLDN4	6.2485440953206
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	78/2577	157/9376	1.80758250965795	DUSP2/GPR132/MAP2K1/PPARD/MAPKAPK2/SGK1/AXL/ITGAV/PTGS2/RAB7A/DUSP5/ADAM17/HIF1A/SPHK1/PLA2G6/DUSP16/PTGER4/TGFB1/ATP11B/SIRT1/ATP2A2/RAB5A/MAPK1/HAVCR2/CRK/NFATC1/ABCA1/ALOX5/SIRPA/RXRA/CPT1A/PTPN11/SLC16A1/HAVCR1/ATP11C/IL10/TMEM30A/NR1H2/ANO6/LIPA/MAPK13/ATP11A/MERTK/PPARG/CASP3/VPS41/MAPK14/ODC1/SIGLEC10/NFATC3/THBS1/CREB1/RAB7B/PANX1/ELMO1/CAMK2G/RAB5B/P2RY6/CAMK2D/VPS11/DUSP4/CEBPB/ATP2A3/PTGER2/MFGE8/VPS18/ATP8A1/RAC1/DUSP8/JAK2/XKR6/SCARF1/ITGB3/C1QB/ATP2A1/CH25H/C1QC/ANO5	6.28224906222969
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	48/2577	82/9376	2.12975950481274	HLA-DQA1/HLA-DRB1/CD74/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-B/HLA-A/HLA-DPA1/CIITA/HLA-DOA/HLA-DMB/HLA-DQA2/HLA-DMA/CTSS/TNF/HSPA1B/HLA-F/HLA-E/HSP90AA1/HSP90AB1/HLA-DQB2/HSPA8/HSPA6/HSPA4/TAPBP/HSPA5/HLA-C/HSPA1A/IFI30/CANX/PSME1/CD4/TAP2/NFYC/B2M/TAP1/CREB1/PDIA3/TAPBPL/CTSB/KLRD1/CTSL/RFX5/HLA-G/HSPA1L/HLA-DOB	6.32574852361343
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	59/2577	109/9376	1.96937623935093	NFKBIA/MAP2K3/MAP2K1/TRAF3/STAT1/TLR2/NFKB1/CXCL8/IL1B/PIK3R1/TBK1/RIPK1/CD80/JAK1/TAB2/TNF/MAP3K8/PIK3CB/IFNAR2/TLR1/AKT3/MAPK1/IFNAR1/TICAM1/TLR7/IRF7/MYD88/CD86/STAT2/PIK3R3/IRAK1/IRF9/TLR5/MAP2K4/MAPK8/MAPK13/TRAF6/TLR4/IL6/TYK2/CASP8/MAPK14/RELA/CD40/CHUK/TLR8/TICAM2/IRF5/TOLLIP/TLR6/AKT2/MAP2K7/IKBKE/RAC1/CXCL9/CXCL10/TLR3/CCL3L1/CCL4L2	6.2669519480491
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	41/2577	66/9376	2.26018038357969	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/STAT1/TLR2/NFKB1/IL1B/HLA-DMB/STAT4/STAT3/HLA-DQA2/HLA-DMA/SMAD3/TNF/TGFB1/IL1A/IL4R/HLA-DQB2/NFATC1/IFNGR2/SMAD2/TLR5/IL10/NOD2/IL18/STAT6/TLR4/IFNGR1/IL6/RELA/IL2RG/IL21R/IL12RB1/IL23A/TGFB2/HLA-DOB	6.32484910965403
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	112/2577	253/9376	1.61064816305997	NFKBIA/CD44/ITGA5/MALT1/SQSTM1/CYTH1/NFKB1/CXCL8/IL1B/ITPR1/PRKCE/FNBP1/SEPTIN6/UBE2D1/PIK3R1/TBK1/UBC/RIPK1/PLCG2/BCL2/TAB2/FOXO1/CAST/C3/NLRP3/CGAS/TNIP1/DIAPH1/TNF/NAIP/CAPN2/MAP1LC3B/UBE2D3/CUL1/PIK3CB/RIPK2/TLN1/MDM2/FOXO3/AKT3/HK1/MAPK1/SRC/ARHGEF2/CRK/RRAGD/ATG16L1/WIPI2/RPTOR/MYD88/NFKBIB/UBE2N/HCLS1/UBE2D2/ACTN1/PIK3R3/FBXW11/RRAGC/ATG5/TLR5/HK2/MAPK8/IL18/BECN1/MAPK13/CASP4/GSK3A/SEPTIN9/TRAF6/TLR4/CALCOCO2/WIPI1/RPS6KB1/BCL10/GSK3B/ACTR3/ROCK1/PPID/ATG12/RPS6KA5/WASL/CYTH4/SEPTIN2/PLCB2/MAPK14/RELA/RHOA/CHUK/CYCS/ATG14/PIK3C3/ACTR2/TAB3/ELMO1/PRKCD/U2AF1/CYTH3/U2AF1L4/CDC42/AKT2/TRAF5/RNF31/RAC1/PIK3R4/ITGB1/BNIP3/MYL5/ARPC5/TRAF2/CSF2/PLCD1/MAP1LC3B2	6.06181677273549
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	63/2577	120/9376	1.91012805587893	NFKBIA/IRAK2/RAPGEF1/MAP2K1/MAPKAPK2/SH2B3/NFKB1/PIK3R1/PLCG2/BCL2/GRB2/PSEN1/RPS6KA3/IRAK3/NFKBIE/ATF4/PIK3CB/RIPK2/FOXO3/AKT3/MAPK1/CRK/RAF1/KRAS/NFKBIB/BRAF/SOS2/PDPK1/PTPN11/PIK3R3/IRAK1/MAPK8/MAPK13/RAP1A/TRAF6/FRS2/GSK3B/RPS6KA5/RPS6KA1/GAB1/RAP1B/PRDM4/MAPK14/NRAS/RELA/RHOA/MAP3K1/MAP3K5/ZNF274/CAMK2G/PRKCD/ABL1/CAMK2D/RPS6KA2/CDC42/AKT2/ARHGDIB/MAP2K7/RAC1/SH2B2/SHC3/CALM1/NTRK3	6.17734389302936
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	53/2577	95/9376	2.0298102648939	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/VEGFA/CXCL3/HLA-DPA1/CXCL2/HLA-DOA/TLR2/CXCL8/IL1B/HLA-DMB/TNFSF13B/ATP6V1H/HLA-DQA2/CD80/HLA-DMA/ICAM1/TNF/TGFB1/CXCL1/IL1A/CCL20/ATP6V1C1/ATP6V1A/HLA-DQB2/IL15/CD86/ATP6V1B2/ATP6V1E1/TNFSF13/IL18/ATP6V1D/TLR4/ATP6V0A1/IL6/ATP6AP1/ATP6V0D1/ACP5/CTSL/ATP6V0A2/ITGB2/IL23A/CXCL5/CXCL12/CSF2/TGFB2/CCL3L1/CTLA4/HLA-DOB	6.21072013454503
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	88/2577	187/9376	1.71215960190828	NFKBIA/CXCL3/TNFAIP3/TRAF3/CXCL2/NAMPT/STAT1/NFKB1/CXCL8/IL1B/ITPR1/GABARAPL1/TBK1/RIPK1/BCL2/GBP2/JAK1/TAB2/OAS2/NLRP3/BIRC3/ERBIN/TNF/BIRC2/NAIP/CXCL1/MAP1LC3B/HSP90AA1/IFNAR2/RIPK2/HSP90AB1/P2RX7/TANK/MAPK1/IFNAR1/TICAM1/IRF7/GBP4/ATG16L1/MYD88/NFKBIB/OAS3/OAS1/STAT2/GBP1/TRPM7/DNM1L/ATG5/IRF9/NLRP1/MAPK8/NOD2/GBP5/IL18/MAPK13/CASP4/TRAF6/TLR4/TRPM2/IL6/ATG12/TYK2/CASP8/PLCB2/MAPK14/RELA/RHOA/CHUK/MFN2/TAB3/PANX1/PRKCD/MCU/NEK7/TXN/MFN1/GBP3/CTSB/TRAF5/RNF31/IKBKE/NLRP12/MEFV/TRAF2/AIM2/DEFA3/MAP1LC3B2/TXNIP	6.05597869392274
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	90/2577	193/9376	1.69663483867855	NFKBIA/CXCL3/MAP2K1/CXCL2/PTK2B/CXCR4/STAT1/PIK3R5/NFKB1/CXCL8/PIK3R1/STAT3/PLCG2/PAK1/GRB2/GNB4/CXCL16/CXCL1/CCL20/HCK/PIK3CB/FOXO3/AKT3/MAPK1/PREX1/SRC/GNAI3/CRK/TIAM1/GNB1/RAF1/FGR/GNG7/WAS/KRAS/NFKBIB/BRAF/SOS2/DOCK2/CCL21/LYN/STAT2/PIK3R3/PRKCB/ARRB2/STAT5B/VAV2/PIK3CG/VAV1/GSK3A/RAP1A/GSK3B/NCF1/GNAQ/ROCK1/PIK3R6/RAP1B/PLCB2/NRAS/RELA/RHOA/CHUK/ADCY3/VAV3/GRK6/ELMO1/PRKCD/GRK3/RASGRP2/CCL18/CCR5/CDC42/AKT2/CCR7/RAC1/CCL14/JAK2/SHC3/CXCL9/CCL8/CXCL5/CXCL12/GNB5/GNG4/GNGT2/CXCL10/CCL3L1/GRK4/CCL4L2/CCR3	6.02021330119702
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	69/2577	137/9376	1.83244818707885	NFKBIA/MAP2K1/ERN1/MCL1/EIF2AK3/NFKB1/GADD45B/CFLAR/BCL2L11/ITPR1/IL3RA/LMNA/PMAIP1/PIK3R1/TRAF1/RIPK1/BCL2/CTSS/DDIT3/BIRC3/BCL2A1/CTSH/TNF/BIRC2/CAPN2/ATF4/PIK3CB/TNFRSF10B/AKT3/BID/MAPK1/PARP4/RAF1/KRAS/TUBA1C/CTSD/PDPK1/GADD45A/SPTAN1/PIK3R3/GADD45G/MAPK8/TUBA4A/CASP3/APAF1/MAP3K14/CASP8/EIF2S1/NRAS/RELA/CHUK/CYCS/MAP3K5/CASP10/TNFRSF10A/CASP9/CTSB/TUBA1A/CTSL/TNFSF10/AKT2/AIFM1/LMNB1/FAS/TRAF2/CTSZ/CTSV/PIDD1/DIABLO	6.04262076454484
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	82/2577	174/9376	1.71461960133631	PPP1R15A/ERN1/DNAJB1/ERO1B/HSPH1/EIF2AK3/NFE2L2/UBE2D1/EDEM1/BCL2/SEC24A/DDIT3/NPLOC4/UBQLN1/HSPA1B/CAPN2/STT3B/UBE2D3/HERPUD1/CUL1/ATF4/OS9/ERO1A/HSP90AA1/ATF6/MAGT1/SSR1/HSP90AB1/HSPA8/HSPA6/DNAJC3/UBE2G1/UBE2G2/HSPA5/SEL1L/DNAJA1/DNAJB12/UBE2J1/DNAJC5/VCP/HSPA1A/SEC24D/SEC13/UBE2D2/SEC31A/NGLY1/SEC63/RAD23A/CANX/UFD1/RRBP1/MAPK8/SAR1B/XBP1/BAG1/RAD23B/DNAJC1/SAR1A/UBXN2A/SEC24B/RPN1/SEC24C/UBXN4/PLAA/EIF2S1/SELENOS/MAP3K5/DERL1/RNF185/NSFL1C/PDIA3/UGGT1/HYOU1/DNAJB2/CRYAB/MAP2K7/FBXO6/HSPBP1/TRAF2/SVIP/HSPA1L/SEC61A2	5.85772205538395
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	52/2577	98/9376	1.93054730623332	MAP2K1/GAB2/PRKCE/PIK3R1/PLCG2/PAK1/FCGR2B/SPHK1/PLA2G6/HCK/PIK3CB/SYK/DNM2/AKT3/MAPK1/INPP5D/CRK/RAF1/PIP5K1A/FCGR2A/WAS/PTPRC/MARCKSL1/LIMK2/VASP/LYN/PIK3R3/PRKCB/INPPL1/VAV2/VAV1/PIP5K1C/RPS6KB1/ACTR3/NCF1/FCGR1A/PLA2G4C/VAV3/ACTR2/PRKCD/FCGR3A/PRKCG/PLD2/CDC42/AKT2/PLA2G4A/RAC1/PIP5K1B/MARCKS/ARPC5/ASAP1/FCGR3B	5.7009159336999
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	61/2577	122/9376	1.81916957702755	NFKBIA/MAP2K1/MALT1/LCP2/NFKB1/PIK3R1/PAK1/GRB2/PPP2CA/TNF/MAP3K8/NFKBIE/PIK3CB/AKT3/PPP2R5C/MAPK1/NFATC1/RAF1/KRAS/PPP2R2D/PTPRC/NFKBIB/PPP2R2A/SOS2/PDPK1/PAK2/PTPN11/PIK3R3/IL10/MAPK8/VAV2/MAPK13/VAV1/PPP2R5A/BCL10/GSK3B/CD4/TEC1/MAP3K14/MAPK14/NRAS/RELA/NFATC3/RHOA/CHUK/PPP3R1/PPP2R5E/VAV3/PPP2R1A/FYN/PPP3CA/CDC42/AKT2/CARD11/PPP2R1B/MAP2K7/PPP2R3A/CBLB/CSF2/PPP2R5B/CTLA4	5.60672569920453
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	74/2577	157/9376	1.71488597070113	CDKN1A/HLA-B/HLA-A/RASSF5/MAP2K3/MAP2K1/MAPKAPK2/SQSTM1/NFKB1/GADD45B/CXCL8/ITPR1/PIK3R1/FOXO1/SMAD3/MRAS/HIPK2/TGFB1/SIRT1/CAPN2/IL1A/HLA-F/HLA-E/PIK3CB/MDM2/FOXO3/AKT3/MAPK1/NFATC1/RAF1/KRAS/HLA-C/NBN/GADD45A/RB1/HUS1/SMAD2/TRPM7/PIK3R3/FBXW11/GADD45G/RHEB/LIN54/RBBP4/MAPK13/E2F3/PPID/IL6/HIPK3/MAPK14/NRAS/RELA/NFATC3/PPP3R1/RAD9A/HIPK4/CCND3/PPP1CB/ZFP36L2/TGFBR2/MCU/PPP3CA/PTEN/AKT2/TRAF3IP2/SERPINE1/HLA-G/TRPV4/CACNA1D/CALM1/CDKN2B/TGFB2/CCNE1/RAD9B	5.56115525699107
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	40/2577	70/9376	2.07905094517434	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-B/HLA-A/HLA-DPA1/HLA-DOA/ABL2/HLA-DMB/HLA-DQA2/CD80/HLA-DMA/ICAM1/HLA-F/HLA-E/BID/HLA-DQB2/CD86/HLA-C/EIF4G1/SNTB1/CD55/EIF4G2/CASP3/CASP8/CD40/CYCS/ABL1/FYN/CASP9/SSPN/ITGB2/RAC1/HLA-G/EIF4G3/DAG1/HLA-DOB	5.57865844331147
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	53/2577	103/9376	1.87215509868855	ETF1/NXF1/PCF11/PABPC1/PABPC4/FUS/PPP2CA/EIF4A3/PPP2R5C/SMG1/ACIN1/GSPT1/PPP2R2D/WDR33/PPP2R2A/SMG7/PAPOLA/SSU72/SMG6/NXT1/RBM8A/RNMT/CPSF6/WDR82/PPP2R5A/RNPS1/RNGTT/PNN/TARDBP/CPSF7/HBS1L/PAPOLG/UPF1/SRRM1/UPF3B/PPP2R5E/PPP2R1A/SYMPK/NCBP1/PPP1CB/NXT2/DDX19B/CPSF3/NUDT21/SMG5/MSI2/PPP2R1B/PABPC1L/PPP2R3A/BCL2L2-PABPN1/CLP1/PPP2R5B/GSPT2	5.47926787880245
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	97/2577	224/9376	1.57553079438993	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/CDKN1A/NFKBIA/HLA-B/HLA-A/RELB/HLA-DPA1/ETS2/MAP2K1/HLA-DOA/FOSL1/NFKB1/HLA-DMB/PIK3R1/HLA-DQA2/JAK1/NFKB2/HLA-DMA/CREB5/SMAD3/EP300/ICAM1/TNF/TGFB1/MAD1L1/CREBBP/HLA-F/ATF4/HLA-E/PIK3CB/TLN1/AKT3/HLA-DQB2/MAPK1/NFATC1/IL15/KRAS/TRRAP/HLA-C/STAT5A/KAT2B/RB1/SMAD2/PIK3R3/CANX/MAP2K4/XPO1/MAPK8/STAT5B/ELK4/E2F3/CD4/CRTC3/IL6/ZFP36/MAP3K14/NRAS/RELA/CD40/NFATC3/CHUK/MAP3K1/B2M/PPP3R1/ADCY3/POLB/CREB1/ANAPC5/CCND3/TGFBR2/IL2RG/SPI1/VAC14/PPP3CA/IL1R2/RANBP3/CREB3/PTEN/AKT2/IL15RA/IL2RA/EGR2/ITGB2/HLA-G/SRF/ELK1/CSF2/CDKN2B/TGFB2/HLA-DOB/ANAPC2/CCNE1	5.36728796114745
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	123/2577	300/9376	1.49171905316259	NR4A1/VEGFA/RELB/DUSP2/MAP2K3/MAP2K1/MAPKAPK2/NFKB1/GADD45B/IL1B/DUSP5/GNA12/PAK1/NFKB2/TAB2/GRB2/DUSP10/DDIT3/MRAS/DUSP16/TNF/TGFB1/MAP3K8/HSPA1B/IL1A/RPS6KA3/ATF4/RAPGEF2/AKT3/HSPA8/MAPK1/TAOK3/HSPA6/EREG/STK4/IL1RAP/CRK/NFATC1/PPM1B/RAF1/MKNK2/MYD88/KRAS/BRAF/SOS2/HSPA1A/MAP3K2/PAK2/GADD45A/PDGFB/PPM1A/GADD45G/PRKCB/IRAK1/DUSP1/MAP2K4/ARRB2/MAPK8/MAPK13/RAP1A/TRAF6/ELK4/MAX/MAP4K4/LAMTOR3/CASP3/TAOK1/RPS6KA5/RPS6KA1/RAP1B/MAP3K14/MAPK14/DUSP3/NRAS/RELA/NFATC3/CHUK/RASGRP3/PLA2G4C/MAP3K1/FLNA/PPP3R1/INSR/MAP3K5/MAP3K4/AREG/TGFBR2/MAP4K3/PTPN7/PPP3CA/EFNA2/RPS6KA2/DUSP4/RASGRP2/PRKCG/ARAF/CDC42/AKT2/PLA2G4A/MAPK8IP3/MAP2K7/MAP3K21/RAC1/JUND/DUSP8/SRF/PDGFA/CACNA1D/FAS/CACNA1G/ELK1/MAPK8IP1/TRAF2/RASGRF1/FGFR1/TGFB2/MET/HSPA1L/EPHA2/MAP4K1/FLT3/HSPB1/CACNB1	5.3290616851247
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	49/2577	93/9376	1.91697439299677	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/NFKBIA/HLA-DPA1/HLA-DOA/STAT1/NFKB1/HLA-DMB/STAT4/HLA-DQA2/JAK1/HLA-DMA/NFKBIE/IL4R/HLA-DQB2/MAPK1/NOTCH2/NFATC1/RUNX3/NFKBIB/MAML3/STAT5A/IFNGR2/MAPK8/STAT5B/NOTCH1/STAT6/MAPK13/MAML1/CD4/IFNGR1/TYK2/MAPK14/RELA/NFATC3/CHUK/PPP3R1/IL2RG/PPP3CA/JAG1/IL2RA/IL12RB1/JAK2/DLL1/HLA-DOB	5.47110228077313
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	45/2577	83/9376	1.97259351725879	JARID2/EZH2/RYBP/UBE2D1/EP300/FOXK2/UBE2D3/ASXL1/CREBBP/PHC2/YAF2/PCGF5/LCOR/USP16/USP7/L3MBTL4/CBX4/YY1/KDM2A/FBRSL1/SCML1/UBE2D2/TFDP1/RBBP4/AEBP2/ASXL2/FBRS/CSNK2B/MAX/FOXK1/BCOR/KDM2B/OGT/SUZ12/PHF19/HCFC1/RNF2/PHF1/TEX10/CBX6/SFMBT2/E2F6/MBD6/PHC1/EPOP	5.4791447633304
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	61/2577	125/9376	1.77550950717889	MAP2K1/GNA13/NFKB1/GAB2/GNA12/PRKCE/PIK3R1/BCL2/NSMAF/PPP2CA/SPHK1/TNF/PIK3CB/AKT3/BID/PPP2R5C/MAPK1/GNAI3/RAF1/KRAS/PPP2R2D/PPP2R2A/SGMS2/CTSD/SGPL1/PDPK1/ABCC1/PIK3R3/PRKCB/MAPK8/MAPK13/PPP2R5A/GNAQ/ROCK1/ORMDL2/PLCB2/MAPK14/NRAS/RELA/RHOA/PPP2R5E/MAP3K5/CERS5/PPP2R1A/SPTLC3/SGPP2/CERS6/FYN/PRKCG/PLD2/PTEN/AKT2/ASAH1/PPP2R1B/RAC1/PPP2R3A/ADORA3/TRAF2/ACER2/FCER1A/PPP2R5B	5.37363444625582
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	42/2577	77/9376	1.9845486294846	CDKN1A/VEGFA/MAP2K1/STAT1/RALA/RALGDS/NFKB1/GADD45B/PIK3R1/STAT3/JAK1/SMAD3/TGFB1/PIK3CB/AKT3/MAPK1/RAF1/BRCA2/KRAS/BRAF/GADD45A/RB1/SMAD2/PIK3R3/GADD45G/MAPK8/RALB/E2F3/RPS6KB1/RELA/CHUK/RALBP1/TGFBR2/DDB2/CASP9/PLD2/ARAF/CDC42/AKT2/RAC1/TGFB2/RAD51	5.34053465519543
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	42/2577	77/9376	1.9845486294846	CDKN1A/NFKBIA/MAP2K1/NFKB1/GADD45B/GAB2/PIK3R1/GRB2/CTBP2/SMAD3/TGFB1/PIK3CB/MDM2/AKT3/MAPK1/CRK/RAF1/RUNX1/KRAS/BRAF/SOS2/STAT5A/GADD45A/PTPN11/RB1/PIK3R3/GADD45G/STAT5B/E2F3/CBL/CDKN1B/NRAS/RELA/CHUK/TGFBR2/DDB2/ABL1/ARAF/AKT2/BCR/SHC3/TGFB2	5.34053465519543
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	89/2577	205/9376	1.57957163273612	CDKN1A/NFKBIA/HLA-B/HLA-A/TRAF3/MAPKAPK2/REL/NFKB1/PMAIP1/PIK3R1/TRAF1/STAT3/JAK1/NFKB2/GRB2/CREB5/EIF2AK2/GTF2A1/EP300/C3/MAD1L1/CREBBP/HLA-F/ATF4/HLA-E/PIK3CB/SYK/HDAC4/MDM2/MAPK1/SRC/GTF2B/USP7/IRF7/EGR3/UBR4/YWHAG/KRAS/YWHAQ/PKM/HLA-C/DDX3X/CHD4/SNW1/STAT5A/LYN/KAT2B/RB1/ACTN1/PIK3R3/SND1/YWHAZ/IRF9/SP100/UBE3A/STAT5B/PSMC1/DDB1/GTF2H1/CASP3/CDKN1B/CASP8/ATP6V0D1/NRAS/RELA/RHOA/GTF2E2/POLB/CREB1/CCND3/VAC14/YWHAH/GTF2H3/CCR5/CREB3/YWHAB/CDC42/TRAF5/HDAC3/EGR2/RAC1/HDAC6/HLA-G/SRF/SCRIB/TRAF2/CDKN2B/CCNE1/CCR3	5.16530572094384
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	39/2577	70/9376	2.02707467154499	CDKN1A/VEGFA/RAPGEF1/MAP2K1/PIK3R1/PAK1/GRB2/EP300/HIF1A/TGFB1/CREBBP/PIK3CB/AKT3/MAPK1/CRK/EGLN1/RAF1/KRAS/BRAF/SOS2/PAK2/PTPN11/PDGFB/VHL/PIK3R3/TFE3/RAP1A/GAB1/RAP1B/PRCC/NRAS/CUL2/ARAF/CDC42/AKT2/RAC1/EGLN3/TGFB2/MET	5.3099427918114
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	91/2577	214/9376	1.54714421971502	NFKBIA/HLA-B/HLA-A/MAP2K3/MAP2K1/TNFRSF1B/PTK2B/CXCR4/TLR2/NFKB1/ITPR1/PIK3R1/TBK1/RIPK1/PLCG2/PAK1/BCL2/TAB2/CGAS/TNF/GNB4/HLA-F/CUL1/HLA-E/PIK3CB/AKT3/BID/MAPK1/GNAI3/CRK/NFATC1/GNB1/RAF1/TAPBP/AP1G1/GNG7/MYD88/KRAS/LIMK2/SAMHD1/HLA-C/PAK2/PIK3R3/FBXW11/PRKCB/IRAK1/MAPK8/CUL4A/MAPK13/DDB1/TRAF6/TLR4/RPS6KB1/CASP3/CD4/GNAQ/TAP2/DCAF1/CASP8/MAPK14/NRAS/RELA/AP1B1/NFATC3/CHUK/B2M/PPP3R1/CYCS/TAP1/AP1S3/PDIA3/TAPBPL/CASP9/PPP3CA/AP1M1/CCR5/PRKCG/AKT2/TRAF5/MAP2K7/RAC1/HLA-G/APOBEC3A/FAS/CALM1/WEE1/GNB5/TRAF2/GNG4/GNGT2/APOBEC3F	4.98464099986228
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	45/2577	87/9376	1.88189956244229	CDKN1A/MAP2K1/RALA/RALGDS/GADD45B/BCL2L11/PMAIP1/PIK3R1/BCL2/GRB2/SMAD3/TGFB1/PIK3CB/AKT3/MAPK1/EREG/RAF1/KRAS/BRAF/SOS2/GADD45A/SMAD2/PIK3R3/GADD45G/TCF7/MAPK8/RALB/RPS6KB1/CASP3/GSK3B/MLH1/NRAS/RHOA/CYCS/AREG/TGFBR2/DDB2/CASP9/AXIN1/ARAF/AKT2/RAC1/CTNNB1/TGFB2/APC2	5.08761921477737
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	51/2577	103/9376	1.80150773647389	NFKBIA/TLR2/NFKB1/CFLAR/CXCL8/IL1B/PIK3R1/GNAL/C3/PPP2CA/TNF/TGFB1/GNA15/PIK3CB/AKT3/MAPK1/TICAM1/GNAI3/MYD88/PPP2R2D/PPP2R2A/IFNGR2/SMAD2/PIK3R3/IRAK1/MAP2K4/IL10/MAPK8/MAPK13/TRAF6/TLR4/GNAQ/IFNGR1/IL6/CASP8/PLCB2/MAPK14/RELA/CHUK/PPP2R1A/TGFBR2/TLR6/AKT2/PPP2R1B/SERPINE1/GNAS/FAS/TGFB2/C1QB/CCL3L1/C1QC	5.03542959466354
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	58/2577	122/9376	1.72970222078029	MAP2K1/STAT1/ITGAV/PIK3R1/MED13/PLCG2/ATP1A1/FOXO1/EP300/HIF1A/SLC9A1/CREBBP/ATP2A2/PIK3CB/SIN3A/MDM2/AKT3/MAPK1/SRC/NOTCH2/NCOA3/RAF1/ATP1B3/KRAS/RXRA/PDPK1/KAT2B/PIK3R3/PRKCB/RHEB/NOTCH1/GSK3B/MED17/NCOR1/PLCB2/NRAS/MED27/MED1/PFKP/CASP9/SLC16A10/PRKCG/RCAN1/AKT2/ATP2A3/ESR1/HDAC3/NCOA2/CTNNB1/ITGB3/PLCD1/ATP2A1/MED12/NOTCH4/PLN/MED13L/FXYD2/ATP1B2	4.9943751681563
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	62/2577	133/9376	1.69606787632644	SOD2/CDKN1A/MAP2K1/PRKAG2/SGK1/BCL6/GADD45B/BCL2L11/IRS2/GABARAPL1/PLK3/PIK3R1/STAT3/GRB2/FOXO1/SMAD3/EP300/HOMER1/TGFB1/SIRT1/CREBBP/PLK2/PIK3CB/MDM2/FOXO3/AKT3/MAPK1/STK4/USP7/RAF1/KRAS/BRAF/SOS2/PDPK1/GADD45A/SGK3/PIK3R3/GADD45G/IL10/MAPK8/MAPK13/CDKN1B/CAT/IL6/ATG12/MAPK14/NRAS/CHUK/INSR/PRKAG1/TGFBR2/PRKAA1/PTEN/ARAF/TNFSF10/AKT2/BNIP3/FBXO32/CDKN2B/TGFB2/IL7R/PRKAB1	4.97727070957245
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	49/2577	98/9376	1.81916957702755	INPP5A/ITPR1/PIK3R1/PLCG2/PI4K2A/PIK3CB/PI4KB/MTMR14/INPP5D/IPMK/DGKD/ITPK1/PIP5K1A/INPP4A/MTMR3/ITPKB/SYNJ2/PIK3R3/IP6K1/PRKCB/PIP4K2A/SYNJ1/INPPL1/PIK3C2A/PIKFYVE/PPIP5K2/MTMR6/PIP5K1C/PLCB2/IMPA2/DGKA/CDS2/ITPKC/IPPK/PIK3C3/INPP5F/PI4K2B/IMPA1/PIP4P1/PRKCG/PTEN/INPP1/DGKE/MTMR1/PIP5K1B/CALM1/MTMR8/PLCD1/DGKG	5.01857010685671
Human Diseases	Immune disease	hsa05330	Allograft rejection	25/2577	39/9376	2.33226868849686	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-B/HLA-A/HLA-DPA1/HLA-DOA/HLA-DMB/HLA-DQA2/CD80/HLA-DMA/TNF/HLA-F/HLA-E/HLA-DQB2/CD86/HLA-C/IL10/CD40/HLA-G/FAS/HLA-DOB	5.13263962006853
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	41/2577	78/9376	1.91246032456743	INPP5A/PLCG2/PI4K2A/PIK3CB/PI4KB/MTMR14/INPP5D/IPMK/ITPK1/PIP5K1A/INPP4A/MTMR3/ITPKB/SYNJ2/TPI1/IP6K1/PIP4K2A/SYNJ1/INPPL1/PIK3CG/PIK3C2A/PIKFYVE/PPIP5K2/MTMR6/PIP5K1C/PLCB2/IMPA2/ITPKC/IPPK/PIK3C3/INPP5F/PI4K2B/IMPA1/INPP5K/PTEN/INPP1/MTMR1/PIP5K1B/MTMR8/PLCD1/ALDH6A1	4.98180640804866
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	37/2577	68/9376	1.97968453970645	MAP2K1/PPARD/NFKB1/PIK3R1/RARA/STAT3/GRB2/BCL2A1/PIK3CB/AKT3/MAPK1/RAF1/RUNX1/KRAS/BRAF/SOS2/STAT5A/PIK3R3/TCF7/PER2/STAT5B/RPS6KB1/ITGAM/FCGR1A/NRAS/RELA/CHUK/PIM2/SPI1/ARAF/AKT2/JUP/CSF2/ZBTB16/MPO/CEBPE/FLT3	4.99152040114212
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	47/2577	94/9376	1.81916957702755	NFKBIA/CXCL3/TNFAIP3/TRAF3/CXCL2/FOSL1/MAPK6/PTGS2/NFKB1/CXCL8/IL1B/TBK1/TAB2/TNF/CXCL1/CCL20/HSP90AA1/HSP90AB1/MAPK1/MAPK8/MAPK13/TRAF6/CASP3/GSK3B/IL6/FOSB/CASP8/MAPK14/RELA/IL17RA/CHUK/ANAPC5/USP25/TAB3/ELAVL1/CEBPB/CSF3/TRAF5/IKBKE/TRAF3IP2/JUND/CXCL5/TRAF2/CSF2/CXCL10/TRAF4/LCN2	4.9140241489967
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	26/2577	42/9376	2.25230519060554	ACSL3/SAT1/ACSL1/ACSL5/PRNP/FTH1/SLC3A2/MAP1LC3B/HMOX1/SAT2/ACSL4/TFRC/LPCAT3/GCLC/ATG5/SLC11A2/GCLM/SLC39A8/PCBP1/SLC7A11/ATG7/TF/CP/FTL/SLC39A14/MAP1LC3B2	5.00750341886368
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	51/2577	105/9376	1.76719330339819	SQSTM1/EIF2AK3/RAB7A/GABARAPL1/TBK1/UBC/ARIH1/HIF1A/MRAS/RABGEF1/MAP1LC3B/SIAH1/ATF4/HUWE1/BCL2L13/RAB5A/FOXO3/SRC/USP8/SMURF1/SMURF2/KRAS/TBC1D15/VCP/USP15/TFE3/TAX1BP1/MAPK8/OPA1/TFEB/BECN1/CSNK2B/CALCOCO2/BNIP3L/EIF2S1/NRAS/RELA/RAB7B/MFN2/RAB5B/MFN1/TOMM70/TBC1D17/OPTN/TOMM40L/MITF/ULK1/SP1/BNIP3/TRAF2/MAP1LC3B2	4.86694556937901
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	37/2577	69/9376	1.95099345942085	MAP2K3/MAP2K1/LCP2/GAB2/PIK3R1/PLCG2/GRB2/TNF/PIK3CB/SYK/AKT3/MAPK1/INPP5D/RAF1/ALOX5/BTK/KRAS/SOS2/PDPK1/LYN/PIK3R3/MAP2K4/MAPK8/VAV2/MAPK13/VAV1/MAPK14/NRAS/PLA2G4C/VAV3/FYN/AKT2/PLA2G4A/MAP2K7/RAC1/CSF2/FCER1A	4.88109820300822
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	27/2577	45/9376	2.18300349243306	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-B/HLA-A/HLA-DPA1/HLA-DOA/IL1B/HLA-DMB/HLA-DQA2/CD80/HLA-DMA/TNF/IL1A/HLA-F/HLA-E/HLA-DQB2/CD86/HLA-C/IL6/KLRD1/HLA-G/FAS/HLA-DOB	4.89720761127412
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	29/2577	50/9376	2.11023670935196	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/CXCR4/HLA-DMB/TNFSF13B/HLA-DQA2/CD80/HLA-DMA/ITGA4/TGFB1/HLA-DQB2/IL15/CD86/TNFSF13/IL10/IL6/MAP3K14/CD40/ICOSLG/IL15RA/CXCL12/HLA-DOB/ITGB7	4.84588614881075
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	128/2577	333/9376	1.39852075591307	CDKN1A/VEGFA/HLA-B/HLA-A/MX1/MX2/MAP2K1/ITGA5/IRF1/TRAF3/STAT1/ITGAV/PTGS2/NFKB1/PIK3R1/TBK1/ATP6V1H/JAK1/GRB2/FOXO1/CREB5/EIF2AK2/EP300/ITGA4/PPP2CA/PSEN1/TNF/PTGER4/HES1/CREBBP/HLA-F/ATP6V1C1/HLA-E/PIK3CB/IFNAR2/OASL/MDM2/AKT3/PPP2R5C/ATP6V1A/MAPK1/IFNAR1/TICAM1/NOTCH2/RAF1/UBR4/KRAS/PPP2R2D/PKM/PPP2R2A/LFNG/HLA-C/SOS2/CHD4/ATP6V1B2/HES4/ATP6V1E1/MAML3/STAT2/RB1/PIK3R3/ISG15/IRF9/TCF7/RHEB/WNT2B/CSNK1A1/UBE3A/PSMC1/NOTCH1/PPP2R5A/ATP6V1D/MAML1/NFX1/RPS6KB1/CASP3/ATP6V0A1/GSK3B/CDKN1B/TYK2/CASP8/ATP6AP1/ATP6V0D1/NRAS/RELA/CHUK/PPP2R5E/ITGB8/THBS1/CREB1/PPP2R1A/CCND3/AXIN1/DVL3/JAG1/CREB3/PTEN/CDC42/AKT2/PPP2R1B/LAMB3/ATP6V0A2/IKBKE/ITGB1/DVL2/VWF/HLA-G/GNAS/CTNNB1/TNC/ITGB3/FAS/PPP2R3A/SCRIB/WNT5B/LLGL2/APC2/WNT5A/ITGA11/HES6/ITGB4/ITGA10/THBS3/PPP2R5B/TLR3/NOTCH4/CCNE1/ITGB7	4.55865917444425
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	52/2577	110/9376	1.71994214555332	CDKN1A/VEGFA/PFKFB3/IL6R/MAP2K1/NFKB1/PIK3R1/STAT3/PLCG2/BCL2/EIF4E/EP300/HIF1A/HMOX1/CREBBP/PIK3CB/AKT3/HK1/MAPK1/EGLN1/MKNK2/TIMP1/TFRC/IFNGR2/VHL/PIK3R3/PRKCB/HK2/TLR4/RPS6KB1/IFNGR1/CDKN1B/IL6/PGK1/RELA/INSR/CUL2/CAMK2G/PFKP/CAMK2D/LDHA/PRKCG/LDHC/AKT2/PDK1/TF/SERPINE1/ENO1/ENO3/EGLN3/ENO2/ALDOC	4.67593127584438
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	62/2577	138/9376	1.63461614167693	RAPGEF1/MAP2K1/PRKAG2/PTPN1/IRS2/INPP5A/PIK3R1/RHOQ/EIF4E/GRB2/FOXO1/PIK3CB/AKT3/HK1/FLOT1/MAPK1/CRK/RAF1/MKNK2/RPTOR/KRAS/BRAF/SOS2/PDPK1/PRKAR2A/PIK3R3/GYS1/HK2/RHEB/MAPK8/INPPL1/PRKAR1A/SOCS1/SREBF1/RPS6KB1/GSK3B/SOCS3/CBL/NRAS/INSR/PPP1R3B/SOCS4/PPP1CB/PRKAG1/PHKA2/PRKAA1/ARAF/SORBS1/PDE3B/AKT2/PYGM/PPP1R3E/PRKAR1B/SH2B2/SHC3/ELK1/CBLB/CALM1/PRKAB1/PPP1R3D/PPP1R3F/PRKAR2B	4.62361863526047
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	64/2577	144/9376	1.61703962402449	NFKBIA/CXCL3/MAP2K3/TRAF3/CXCL2/PRKAG2/C5AR1/NFKB1/CXCL8/IL1B/TBK1/RIPK1/TAB2/FOXO1/C3/TNF/SIRT1/CXCL1/ADIPOR2/LPIN2/FOXO3/AKT3/TRA2B/TICAM1/LPIN1/MYD88/CPT1A/SCD/ALDH2/IRAK1/TCF7/MAP2K4/MAPK8/CAMKK2/MAPK13/SREBF1/TRAF6/TLR4/CASP3/GSK3B/IL6/MAP3K14/CASP8/ACOX1/MAPK14/RELA/IL17RA/CHUK/ALDH3A2/MAP3K5/TAB3/PRKAG1/C3AR1/TRA2A/PRKAA1/AKT2/ACOX3/MAP2K7/IKBKE/CTNNB1/FAS/C1QB/PRKAB1/C1QC	4.59374336083984
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	26/2577	44/9376	2.14992768194165	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-B/HLA-A/HLA-DPA1/HLA-DOA/IL1B/HLA-DMB/HLA-DQA2/CD80/HLA-DMA/TNF/IL1A/HLA-F/HLA-E/HLA-DQB2/HSPD1/CD86/HLA-C/HLA-G/FAS/HLA-DOB	4.70684426245056
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	44/2577	90/9376	1.77874358642694	NFKBIA/MAP2K3/MAP2K1/STAT1/TLR2/NFKB1/PIK3R1/STAT3/JAK1/HIF1A/NFKBIE/PIK3CB/AKT3/MAPK1/TICAM1/NFATC1/RAF1/MYD88/KRAS/NFKBIB/PTPN11/IFNGR2/PIK3R3/MAPK13/TRAF6/CSNK2B/TLR4/RPS6KB1/CD4/IFNGR1/MAPK14/NRAS/RELA/NFATC3/CHUK/PPP3R1/TICAM2/PPP3CA/EML4/PTEN/AKT2/BATF3/JAK2/CD274	4.57005813675242
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	84/2577	204/9376	1.49813965166975	CDKN1A/VEGFA/CD44/MAP2K1/ITGA5/PLAUR/HBEGF/ITGAV/TLR2/ITPR1/PIK3R1/STAT3/PLCG2/PAK1/GRB2/EZR/PLAU/HIF1A/MRAS/TNF/TGFB1/SLC9A1/PIK3CB/MDM2/AKT3/MSN/MAPK1/RDX/SRC/TIAM1/DDX5/RAF1/KRAS/BRAF/SOS2/PDPK1/HCLS1/SDC2/PTPN11/IQGAP1/SMAD2/PIK3R3/PRKCB/WNT2B/VAV2/PPP1R12A/MAPK13/EIF4B/VAV1/SDC4/HPSE/TLR4/FRS2/RPS6KB1/CASP3/ROCK1/CBL/GAB1/MAPK14/NRAS/RHOA/FLNA/THBS1/VAV3/PPP1CB/CAMK2G/CAMK2D/PRKCG/ARAF/CTSL/CDC42/AKT2/ESR1/RAC1/ITGB1/CTNNB1/ITGB3/FAS/ELK1/WNT5B/FGFR1/TGFB2/WNT5A/MET	4.42847808968903
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	42/2577	86/9376	1.77686330779435	CDKN1A/MAP2K1/HBEGF/ABL2/PIK3R1/PLCG2/PAK1/GRB2/PIK3CB/AKT3/MAPK1/SRC/EREG/CRK/RAF1/KRAS/BRAF/SOS2/STAT5A/PAK2/PIK3R3/PRKCB/MAP2K4/MAPK8/STAT5B/RPS6KB1/GSK3B/CBL/CDKN1B/GAB1/NRAS/AREG/CAMK2G/ABL1/CAMK2D/PRKCG/ARAF/AKT2/MAP2K7/SHC3/ELK1/CBLB	4.45560112762703
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	37/2577	73/9376	1.84408970821971	CDKN1A/RASSF5/MAP2K1/GADD45B/PIK3R1/STAT3/PLCG2/GRB2/PIK3CB/FOXO3/AKT3/MAPK1/STK4/RAF1/KRAS/BRAF/SOS2/RXRA/PDPK1/STAT5A/GADD45A/RB1/PIK3R3/KIF5B/GADD45G/PRKCB/STAT5B/E2F3/NRAS/DDB2/CASP9/EML4/PRKCG/FHIT/ARAF/AKT2/MET	4.45716643654908
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	62/2577	142/9376	1.58857061655927	UBE2D1/UBC/UBE2S/UBE2R2/BIRC3/BIRC2/UBE2D3/SIAH1/CUL1/UBE2Q2/FBXW7/HUWE1/MDM2/CUL3/UBR5/UBE2L6/UBE2G1/UBE2A/TRIP12/UBE2G2/UBE2H/UBA6/UBE2O/SMURF1/SMURF2/UBE2E1/SAE1/UBE2J1/UBE2N/UBE2Z/UBE2Q1/UBE2D2/VHL/FBXW11/UBA1/UBE3A/ITCH/SOCS1/MGRN1/CUL4A/DDB1/TRAF6/WWP2/UBE4A/SOCS3/CBL/HERC1/PIAS1/FZR1/BIRC6/MAP3K1/ANAPC5/COP1/CUL2/DDB2/HERC3/HERC4/PPIL2/NEDD4L/UBE2E2/CBLB/ANAPC2	4.35079019193616
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	36/2577	71/9376	1.84479168374625	NFKBIA/CXCL3/CXCL2/HBEGF/NFKB1/CXCL8/ATP6V1H/PLCG2/PAK1/ADAM17/CXCL1/ATP6V1C1/ATP6V1A/SRC/ATP6V1B2/ATP6V1E1/LYN/PTPN11/MAP2K4/MAPK8/MAPK13/ATP6V1D/CASP3/ATP6V0A1/F11R/CSK/MAP3K14/MAPK14/ATP6AP1/ATP6V0D1/RELA/CHUK/CDC42/ATP6V0A2/RAC1/MET	4.3988681264197
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	31/2577	59/9376	1.911669725012	CDKN1A/MAP2K1/GADD45B/PIK3R1/GRB2/PIK3CB/FOXO3/AKT3/MAPK1/RAF1/CTNNA1/KRAS/BRAF/SOS2/PDPK1/GADD45A/PIK3R3/GADD45G/TCF7/GSK3B/MLH1/NRAS/DDB2/CASP9/AXIN1/PTEN/ARAF/AKT2/CTNNB1/ELK1/APC2	4.32459874382244
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	38/2577	78/9376	1.77252420325761	BTG1/HSPA9/TOB1/PABPC1/PABPC4/TENT4A/DCP1A/BTG3/CNOT1/TENT4B/TOB2/HSPD1/DDX6/DHX36/PATL1/BTG2/CNOT6L/DIS3/XRN2/CNOT6/CNOT4/DCP2/PARN/CNOT2/MPHOSPH6/XRN1/PNPT1/PFKP/EXOSC10/EXOSC9/CNOT10/PABPC1L/ENO1/ENO3/CNOT3/EXOSC5/PAN2/ENO2	4.21778999320982
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	49/2577	109/9376	1.63558365641009	NFKBIA/PRKAG2/PTPN1/NFKB1/IRS2/PRKCE/PIK3R1/STAT3/FOXO1/CREB5/TNF/RPS6KA3/PIK3CB/AKT3/MLXIP/CPT1A/PDPK1/PTPN11/PIK3R3/PRKCB/GYS1/MAPK8/NR1H2/SREBF1/RPS6KB1/GSK3B/SOCS3/IL6/RPS6KA1/OGT/RELA/INSR/PPP1R3B/CREB1/PPP1CB/PRKAG1/PRKCD/RPS6KA2/GFPT1/PRKAA1/CREB3/PTEN/AKT2/PYGM/PPARGC1B/PPP1R3E/GFPT2/PRKAB1/PPP1R3D	4.10900543255985
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	66/2577	158/9376	1.51981255802302	SLC7A5/FNIP2/MAP2K1/SGK1/PIK3R1/ATP6V1H/EIF4E/DDIT4/GRB2/TBC1D7/CLIP1/SLC3A2/TNF/RPS6KA3/ATP6V1C1/SESN2/PIK3CB/LPIN2/AKT3/ATP6V1A/MAPK1/RAF1/LPIN1/RRAGD/RPTOR/CAB39/KRAS/BRAF/SOS2/ATP6V1B2/PDPK1/ATP6V1E1/SEC13/PIK3R3/RRAGC/PRKCB/RHEB/WNT2B/MAPKAP1/FNIP1/EIF4B/ATP6V1D/RPS6KB1/LAMTOR3/GSK3B/RPS6KA1/NRAS/RHOA/CHUK/STRADA/INSR/WDR59/DVL3/RPS6KA2/PRKAA1/DEPDC5/PRKCG/PTEN/ULK1/AKT2/PRR5L/CAB39L/DVL2/GRB10/WNT5B/WNT5A	4.05674104143915
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	46/2577	101/9376	1.65706535729242	VEGFA/STAT1/THBD/NFKB1/CXCL8/IL1B/PRKCE/PIK3R1/STAT3/PLCG2/BCL2/FOXO1/SMAD3/DIAPH1/ICAM1/TNF/TGFB1/IL1A/PIK3CB/AKT3/MAPK1/NFATC1/KRAS/STAT5A/SMAD2/PIK3R3/PRKCB/MAPK8/STAT5B/MAPK13/CASP3/CDKN1B/IL6/PLCB2/MAPK14/NRAS/RELA/PRKCD/TGFBR2/CDC42/AKT2/RAC1/SERPINE1/JAK2/PLCD1/TGFB2	4.08726338708008
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	80/2577	201/9376	1.44809518569357	CDKN1A/BCL6/REL/NFKB1/GADD45B/CXCL8/ETV6/RARA/TRAF1/DOT1L/FOXO1/FUS/DDIT3/PLAU/BIRC3/BCL2A1/BIRC2/CDK14/ID2/AFF1/KDM6A/SIN3A/MDM2/NR4A3/ATF1/DDX5/RUNX1/EWSR1/CD86/RUNX2/PBX3/RXRA/CCNT2/KLF3/GADD45A/JMJD1C/CCNT1/GADD45G/TFE3/SS18/PER2/NFKBIZ/ELK4/PPARG/MAX/CDKN1B/IL6/NCOR1/ITGAM/FCGR1A/PRCC/SS18L1/RELA/CD40/ZBTB17/NSD2/TGFBR2/DDB2/SPI1/IL1R2/LDB1/SUPT3H/CEBPB/CDK9/MITF/PAX8/SP1/PDGFA/JUP/CSF2/ZBTB16/MET/ETV7/DEFA3/MPO/CEBPE/FLT3/PLAT/ITGB7/NUPR1	3.95353508332601
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	13/2577	18/9376	2.6276893890398	MANBA/HEXB/MAN2B1/HEXA/FUCA2/NEU1/MAN2B2/NEU3/AGA/HEXD/MAN2C1/GBA2/NEU4	4.2553627865354
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	48/2577	108/9376	1.61703962402449	KPNA4/NXF1/IPO7/RANBP2/NUP98/EIF4A3/NUP153/TNPO3/ACIN1/IPO5/AHCTF1/POM121/SEC13/NUP58/TPR/KPNB1/TNPO1/NXT1/NUP62/KPNA3/XPO1/RBM8A/KPNA1/TMEM33/KPNA6/RNPS1/NUP210L/PNN/POM121C/SENP2/KPNA2/XPO4/NUP54/UPF1/SRRM1/UPF3B/NUP50/THOC1/NCBP1/RANGAP1/NXT2/DDX19B/NUP88/NUP93/XPOT/XPO5/EEF1A1/NUP210	3.97056441290131
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	45/2577	100/9376	1.6372526193248	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-DPA1/CD44/IL6R/ITGA5/HLA-DOA/CSF2RA/IL1B/IL3RA/HLA-DMB/HLA-DQA2/HLA-DMA/ITGA4/TNF/IL1A/IL4R/HLA-DQB2/CD22/CSF3R/TFRC/CD55/CD37/CD4/IL6/ANPEP/ITGAM/FCGR1A/IL1R2/CD38/CSF3/CD1D/IL2RA/CD1C/ITGB3/CSF2/IL7R/CD1E/CD5/FLT3/HLA-DOB	3.9441333160417
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	47/2577	106/9376	1.61322585132632	CDKN1A/NFKBIA/MAP2K1/NFKB1/PIK3R1/BCL2/GRB2/FOXO1/CREB5/PLAU/EP300/CREBBP/ATF4/HSP90AA1/PIK3CB/HSP90AB1/MDM2/AKT3/MAPK1/RAF1/KRAS/BRAF/SOS2/PDPK1/RB1/PDGFB/PIK3R3/TCF7/E2F3/GSK3B/CDKN1B/NRAS/RELA/CHUK/CREB1/CASP9/IL1R2/CREB3/PTEN/ARAF/AKT2/SLC19A1/PDGFA/CTNNB1/FGFR1/CCNE1/PLAT	3.90889358338302
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	68/2577	168/9376	1.47266108616516	CDKN1A/IL6R/MCL1/CSF2RA/STAT1/IL3RA/PIK3R1/STAT4/STAT3/BCL2/JAK1/GRB2/IL10RA/EP300/IL13RA1/PTPN2/CREBBP/PIK3CB/IFNAR2/IL4R/AKT3/OSM/IFNAR1/RAF1/CSF3R/IL15/SOS2/STAT5A/PTPN11/STAT2/IFNGR2/PDGFB/PIK3R3/IRF9/IL10/SOCS6/STAT5B/SOCS1/STAT6/STAM/IFNGR1/SOCS3/IL6/TYK2/PIAS1/STAM2/SOCS4/CCND3/IL2RG/CLCF1/CSH2/AKT2/CSF3/IL15RA/IL2RA/IL21R/IL12RB1/IL23A/JAK2/PDGFA/IL19/SOCS5/CRLF2/CSF2/IL7R/IL20RB/LIF/IL27	3.80576669387243
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	56/2577	133/9376	1.53193227539162	HLA-B/HLA-A/MAP2K1/LCP2/PTK2B/PIK3R1/PLCG2/PAK1/GRB2/ICAM1/TNF/HLA-E/PIK3CB/IFNAR2/TNFRSF10B/SYK/BID/MAPK1/IFNAR1/NFATC1/RAF1/KRAS/HLA-C/BRAF/SOS2/LAT2/PTPN11/IFNGR2/PIK3R3/PRKCB/CD48/VAV2/VAV1/CASP3/IFNGR1/NRAS/PPP3R1/VAV3/TYROBP/TNFRSF10A/FYN/PPP3CA/FCGR3A/KLRD1/PRKCG/ARAF/TNFSF10/ITGB2/RAC1/HLA-G/SHC3/FAS/CSF2/ULBP2/FCGR3B/CD244	3.80361028547351
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	42/2577	93/9376	1.64312090828295	CDKN1A/NFKBIA/TRAF3/ITGAV/PTGS2/NFKB1/GADD45B/CKS2/PIK3R1/TRAF1/BCL2/BIRC3/BIRC2/PIK3CB/AKT3/RXRA/GADD45A/RB1/PIK3R3/GADD45G/TRAF6/MAX/E2F3/CASP3/APAF1/CDKN1B/RELA/CHUK/ZBTB17/CYCS/DDB2/CASP9/FHIT/PTEN/AKT2/TRAF5/LAMB3/ITGB1/TRAF2/CDKN2B/TRAF4/CCNE1	3.83716306037797
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	52/2577	122/9376	1.55076750828578	PFKFB3/PRKAG2/IRS2/PIK3R1/FOXO1/CREB5/TBC1D1/PPP2CA/SIRT1/ADIPOR2/PIK3CB/FOXO3/AKT3/PPP2R5C/RAB8A/RPTOR/CAB39/PPP2R2D/PPP2R2A/CPT1A/SCD/PDPK1/PIK3R3/GYS1/RHEB/CAMKK2/RAB10/SREBF1/PPP2R5A/PPARG/RPS6KB1/PFKFB4/STRADA/PPP2R5E/INSR/CREB1/PPP2R1A/PRKAG1/ELAVL1/PFKP/RAB2A/PRKAA1/CREB3/ULK1/AKT2/HMGCR/PPP2R1B/CAB39L/PPP2R3A/EEF2/PRKAB1/PPP2R5B	3.76967410605982
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	37/2577	80/9376	1.68273185875049	VEGFA/IL6R/MAP2K1/AXL/BCL2L11/PIK3R1/STAT3/PLCG2/BCL2/EIF4E/JAK1/GRB2/PIK3CB/FOXO3/AKT3/MAPK1/SRC/RAF1/KRAS/BRAF/SOS2/PDGFB/PIK3R3/PRKCB/RPS6KB1/GSK3B/IL6/GAB1/NRAS/PRKCG/PTEN/ARAF/AKT2/JAK2/PDGFA/SHC3/MET	3.77543877577353
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	34/2577	72/9376	1.71810460052602	NFKBIA/TRAF3/ZNFX1/NFKB1/CYLD/CXCL8/TBK1/RIPK1/TRIM25/ADAR/IFIH1/TNF/TANK/IRF7/NFKBIB/DDX3X/AZI2/ATG5/ISG15/MAPK8/OTUD5/MAPK13/TRAF6/ATG12/CASP8/MAPK14/RELA/CHUK/MAP3K1/CASP10/IKBKE/TKFC/TRAF2/CXCL10	3.76564550350455
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	30/2577	62/9376	1.76048668744602	NCOR2/SPEN/CTBP2/EP300/ADAM17/PSEN1/HES1/CREBBP/ATXN1/NOTCH2/TLE3/LFNG/NUMB/SNW1/MAML3/KAT2B/ITCH/DTX3L/NOTCH1/TLE4/NRARP/MAML1/APH1B/DVL3/JAG1/DTX2/DVL2/DLL1/NOTCH4/NUMBL	3.69861963454013
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	40/2577	90/9376	1.61703962402449	SOD2/PRKAG2/NFKB1/IRS2/PIK3R1/EIF4E/FOXO1/CREB5/SIRT1/ADIPOR2/ATF4/SESN2/PIK3CB/FOXO3/AKT3/RB1CC1/RPTOR/KRAS/EHMT1/PIK3R3/ATG5/RHEB/CAMKK2/ATG101/PPARG/RPS6KB1/CAT/NRAS/RELA/ADCY3/INSR/CREB1/ATG13/PRKAG1/SESN1/PRKAA1/CREB3/ULK1/AKT2/PRKAB1	3.6210981427278
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	33/2577	71/9376	1.69105904343406	MAP2K1/IRF1/STAT1/NFKB1/PIK3R1/STAT3/GRB2/PIK3CB/FOXO3/AKT3/MAPK1/SRC/RAF1/KRAS/SOS2/STAT5A/PIK3R3/MAPK8/SOCS6/STAT5B/SOCS1/MAPK13/GSK3B/SOCS3/MAPK14/NRAS/RELA/SOCS4/AKT2/ESR1/JAK2/SHC3/SOCS5	3.59837538427908
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	66/2577	168/9376	1.42934752480736	TNFAIP3/STAT1/CHMP1B/SQSTM1/CYLD/CFLAR/IL1B/CHMP4B/STAT4/RIPK1/STAT3/BCL2/JAK1/GLUL/EIF2AK2/GLUD1/NLRP3/BIRC3/FTH1/TNF/BIRC2/CAPN2/IL1A/CHMP2B/HSP90AA1/IFNAR2/TNFRSF10B/HSP90AB1/BID/IFNAR1/TICAM1/STAT5A/STAT2/VPS4B/IFNGR2/TRPM7/DNM1L/IRF9/CHMP3/MAPK8/STAT5B/STAT6/TLR4/IFNGR1/PPID/TYK2/CASP8/MLKL/PLA2G4C/CAMK2G/TNFRSF10A/TICAM2/SPATA2L/CAMK2D/TNFSF10/TRAF5/RNF31/PLA2G4A/PYGM/AIFM1/JAK2/FAS/TRAF2/FTL/TLR3/ZBP1	3.45701509566934
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	18/2577	32/9376	2.046565774156	GABARAPL1/PPP2CA/ATG16L1/WIPI2/RPTOR/ATG3/ATG5/ATG4B/BECN1/ATG2A/ATG101/WIPI1/ATG12/PIK3C3/ATG13/ATG7/ATG4A/PIK3R4	3.65086209944926
NA	NA	hsa04517	IgSF CAM signaling	108/2577	299/9376	1.31418270447475	ITGAX/MBP/MAP2K1/ITGA5/LCP2/EPB41L3/PIK3R1/PLCG2/PAK1/CD80/NRP2/GRB2/FOXO1/EZR/ITGA4/NECTIN2/ICAM1/TUBB4B/PPFIA1/MYH9/RAPGEF2/PIK3CB/CD84/AKT3/MSN/MAPK1/RDX/SLAMF7/SRC/JAML/NPHS1/INPP5D/SRGAP2/IL1RAP/CD86/TRIO/BAIAP2/TUBA1C/TUBB6/CD2AP/TJP2/PDPK1/PAK2/LYN/APP/PTPN11/SPTAN1/IQGAP1/ACTN1/PIK3R3/PRKCB/CD48/MAPK8/SRGAP1/ERC1/VAV2/MAPK13/VAV1/TUBA4A/RAP1A/TRAF6/MYH11/F11R/GSK3B/ACTR3/RAPGEF6/CSK/WASL/RAP1B/ITGAM/MAPK14/CADM1/RHOA/SRGAP3/CD226/VAV3/ACTR2/ABL1/FYN/TUBA1A/CRTAM/PRKCG/SORBS1/CDC42/AKT2/CADM4/LY9/ITGB2/TUBB3/RAC1/ITGB1/ICAM3/UNC5B/CTNNB1/ITGB3/PLXNA3/ARPC5/NECTIN1/FGFR1/KIRREL2/MAP2/SLAMF1/NTRK3/CABLES2/ROBO3/CD244/SPTBN4/NLGN3	3.39912415004645
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	34/2577	75/9376	1.64938041650498	CDKN1A/GADD45B/PMAIP1/BCL2/ZNF385A/SIAH1/SESN2/TNFRSF10B/MDM2/BID/GADD45A/GADD45G/PPM1D/RRM2B/CASP3/CD82/APAF1/CASP8/SHISA5/CYCS/THBS1/COP1/CCND3/DDB2/TNFRSF10A/CASP9/SESN1/PTEN/SERPINE1/PPP1R13L/FAS/PIDD1/AIFM2/CCNE1	3.47604446933461
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	35/2577	78/9376	1.6325880819478	ITGA5/IRF1/NFKB1/CXCL8/IL1B/C3/NLRP3/IRF8/TNF/IL1A/SERPING1/MAPK1/TICAM1/GNAI3/MYD88/IRAK1/IL10/MAPK8/MAPK13/TRAF6/TLR4/CASP3/IL6/ITGAM/MAPK14/RELA/RHOA/TICAM2/ITGB2/IL23A/ITGB1/CXCL5/CALM1/C1QB/C1QC	3.45377357837097
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	50/2577	122/9376	1.49112260412094	MAP2K3/MAP2K1/STAT1/IRS2/ITPR1/PIK3R1/STAT3/PLCG2/GRB2/CREB5/EP300/CREBBP/ATF4/PIK3CB/AKT3/MAPK1/GNAI3/CRK/RAF1/KRAS/SOS2/STAT5A/PIK3R3/PRKCB/MAP2K4/MAPK8/STAT5B/SOCS1/MAPK13/GSK3B/GNAQ/SOCS3/PLCB2/MAPK14/NRAS/MAP3K1/ADCY3/CREB1/PRKCG/CREB3/CSH2/AKT2/JUNB/GNAS/JAK2/SHC3/CACNA1D/GHRL/SSTR2/ADCY10	3.36144041869433
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	59/2577	149/9376	1.44068463147148	MAP2K1/PTK2B/GNA13/PIK3R5/RALA/RALGDS/CYTH1/CXCL8/GAB2/GNA12/PIK3R1/PLCG2/GRB2/MRAS/SPHK1/PIK3CB/SYK/AGPAT4/DNM2/AKT3/MAPK1/DGKD/RAF1/PIP5K1A/KRAS/SOS2/AGPAT3/PTPN11/PDGFB/PIK3R3/RHEB/PIK3CG/RALB/PIP5K1C/PIK3R6/CYTH4/GAB1/PLCB2/NRAS/DGKA/RHOA/PLA2G4C/ADCY3/INSR/AGPAT1/FYN/CYTH3/PLD2/AKT2/PLA2G4A/DGKE/PIP5K1B/GNAS/PDGFA/SHC3/LPAR2/DGKG/LPAR3/FCER1A	3.33819041559798
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	42/2577	99/9376	1.54353782293247	MAP2K1/RALGDS/CHKA/PIK3R1/GPCPD1/GRB2/HIF1A/PIK3CB/AKT3/MAPK1/DGKD/RAF1/PIP5K1A/SLC22A4/WAS/KRAS/SOS2/PCYT1A/PDPK1/PDGFB/PIK3R3/PRKCB/RHEB/MAPK8/PIP5K1C/RPS6KB1/SLC44A1/NRAS/DGKA/PLA2G4C/CHPT1/PRKCG/PLD2/AKT2/SLC22A1/PLA2G4A/SP1/DGKE/RAC1/PIP5K1B/PDGFA/DGKG	3.34706322731347
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	26/2577	54/9376	1.75179292602653	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-B/HLA-A/HLA-DPA1/HLA-DOA/HLA-DMB/HLA-DQA2/CD80/HLA-DMA/HLA-F/HLA-E/HLA-DQB2/CD86/HLA-C/IL10/CD40/TG/HLA-G/FAS/CTLA4/HLA-DOB	3.41083642628968
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	21/2577	41/9376	1.86353956671115	CDKN1A/VEGFA/MAP2K1/HBEGF/CXCL8/MDM2/MAPK1/SRC/RAF1/KRAS/BRAF/RB1/TYMP/E2F3/RPS6KA5/NRAS/THBS1/DAPK1/ARAF/DAPK3/DAPK2	3.41143684331294
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	28/2577	60/9376	1.69789160522571	VEGFA/MAP2K1/MAPKAPK2/PTGS2/PIK3R1/PLCG2/SPHK1/PIK3CB/AKT3/MAPK1/SRC/RAF1/KRAS/PIK3R3/PRKCB/MAPK13/MAPK14/NRAS/PLA2G4C/PPP3R1/CASP9/PPP3CA/PRKCG/CDC42/AKT2/PLA2G4A/RAC1/HSPB1	3.33863688004897
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	76/2577	203/9376	1.36213682614871	VEGFA/RAPGEF1/MAP2K1/ITGA5/ITGAV/PIK3R1/PAK1/BCL2/GRB2/ITGA4/BIRC3/DIAPH1/BIRC2/CAPN2/PIK3CB/TLN1/AKT3/MAPK1/SRC/PARVB/CRK/RAF1/PIP5K1A/BRAF/SOS2/VASP/PDPK1/PARVG/PAK2/PDGFB/ACTN1/PIK3R3/PRKCB/MAPK8/VAV2/PPP1R12A/ZYX/VAV1/RAP1A/PIP5K1C/GSK3B/ROCK1/RAP1B/RHOA/FLNA/ITGB8/THBS1/VAV3/CCND3/PPP1CB/FYN/EMP1/PRKCG/PTEN/CDC42/AKT2/LAMB3/RAC1/ITGB1/VWF/PIP5K1B/PDGFA/CTNNB1/TNC/MYL5/SHC3/ITGB3/ELK1/RASGRF1/ITGA11/MET/ITGB4/ITGA10/THBS3/EMP2/ITGB7	3.21133298466222
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	26/2577	55/9376	1.71994214555332	PSAP/B4GALT5/SPHK1/UGCG/SAMD8/GLA/HEXB/GM2A/ACER3/CERK/GALC/SGMS2/SGPL1/HEXA/KDSR/NEU1/NEU3/CERS5/SPTLC3/SGPP2/CERS6/ASAH1/SMPD4/GBA2/ACER2/NEU4	3.29661336989638
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	18/2577	34/9376	1.92617955214682	BHLHE40/PRKAG2/NFIL3/PER1/CSNK1D/CUL1/CRY1/NR1D2/FBXW11/PER2/CRY2/PER3/CREB1/PRKAG1/PRKAA1/PRKAB1/NR1D1/RORB	3.33069636061948
Human Diseases	Immune disease	hsa05310	Asthma	17/2577	32/9376	1.93286767559177	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/HLA-DMB/HLA-DQA2/HLA-DMA/TNF/HLA-DQB2/IL10/CD40/FCER1A/HLA-DOB	3.25423525660957
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	32/2577	73/9376	1.59488839629813	ELL2/MX1/MX2/CXCR4/AFF4/CHMP4B/SUPT5H/ELL/EP300/RANBP2/CREBBP/NUP153/TNPO3/BICD2/SAMHD1/CCNT2/KAT2B/CCNT1/VPS4B/PDCD6IP/XPO1/CPSF6/CD4/SERINC5/CPSF7/NELFCD/MDFIC/CCR5/NELFB/CDK9/APOBEC3A/APOBEC3F	3.14127345429303
Human Diseases	Cancer: specific types	hsa05214	Glioma	33/2577	76/9376	1.57980515899761	CDKN1A/MAP2K1/CAMK1D/GADD45B/PIK3R1/PLCG2/GRB2/PIK3CB/MDM2/AKT3/MAPK1/RAF1/KRAS/BRAF/SOS2/GADD45A/RB1/PDGFB/PIK3R3/GADD45G/PRKCB/E2F3/NRAS/CAMK2G/DDB2/CAMK2D/PRKCG/PTEN/ARAF/AKT2/PDGFA/SHC3/CALM1	3.12440787711687
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	28/2577	62/9376	1.64312090828295	SOD2/PRKAG2/IRS2/PIK3R1/FOXO1/SIRT1/HSPA1B/PIK3CB/FOXO3/AKT3/HSPA8/HSPA6/RPTOR/KRAS/HSPA1A/PIK3R3/ATG5/RPS6KB1/CAT/NRAS/ADCY3/INSR/PRKAG1/PRKAA1/AKT2/CRYAB/HSPA1L/PRKAB1	3.12781230496878
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	17/2577	33/9376	1.87429592784657	STX11/STX4/STX3/STX5/STX6/VAMP3/VAMP2/STX8/SNAP23/VAMP7/VTI1A/SNAP29/STX17/VAMP5/BET1L/VAMP1/STX1B	3.0973663655074
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	63/2577	170/9376	1.34832568650277	PRKAG2/PRKCE/EZR/RAB8B/PPP2CA/MYH9/RAPGEF2/MSN/RDX/SRC/ARHGEF2/TIAM1/HSPA4/RUNX1/RAB8A/WAS/PPP2R2D/TUBA1C/PPP2R2A/TJP2/VASP/HCLS1/ACTN1/RAP2C/MAPK8/YBX3/TUBA4A/RAP1A/WHAMM/MYH11/F11R/ACTR3/RAPGEF6/ROCK1/RHOA/MAP3K1/MAP3K5/PPP2R1A/SYMPK/ACTR2/PRKAG1/TUBA1A/MICALL2/NEDD4L/PRKAA1/CDC42/CD1D/PPP2R1B/MAP2K7/TJAP1/RAC1/ITGB1/CLDN1/CACNA1D/CD1C/SCRIB/ARPC5/LLGL2/CD1E/PRKAB1/CLDN12/CLDN6/CLDN4	2.82159582477767
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	45/2577	115/9376	1.42369792984765	CDKN1A/MAP2K1/AKAP13/PDE4B/SGK1/GNA13/HBEGF/ITPR1/GNA12/PDE4A/BCL2/OXSR1/CREB5/NR4A2/MEF2D/ATF4/MAPK1/VDR/GNAI3/RAF1/MAFB/RUNX2/BRAF/RXRA/PRKCB/WNK1/ARRB2/PDE4C/GNAQ/PLCB2/RHOA/ARHGEF11/ADCY3/CREB1/MMP24/PRKCG/CREB3/PLD2/ARAF/SP1/JUND/GNAS/MEF2A/STK39/FGFR1	2.81447015070681
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	41/2577	103/9376	1.44827092540057	CXCL3/CXCL2/TLR2/NFKB1/CXCL8/RAB7A/IL1B/PIK3R1/GNAL/TNF/TGFB1/CXCL1/GNA15/PIK3CB/RAB5A/SERPINB9/ACTN1/PIK3R3/PRKCB/IL10/TLR4/CASP3/GNAQ/IL6/ITGAM/PLCB2/RELA/RAB7B/RAB5B/IL1R2/PRKCG/CD1D/LAMB3/ITGB2/GNAS/CD1C/CSF2/TGFB2/CD1E/HSPB1/SERPINB10	2.81623817396903
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	82/2577	232/9376	1.28596470100223	ITGAX/MAP2K1/ITGA5/CXCR4/GNA13/ITGAV/SSH1/GNA12/PIK3R1/PAK1/EZR/ITGA4/MRAS/DIAPH1/MYH9/SLC9A1/PIK3CB/IQGAP2/AKT3/MSN/MAPK1/RDX/SRC/CRK/TIAM1/RAF1/PIP5K1A/ARHGEF7/KRAS/LIMK2/BAIAP2/BRAF/SOS2/PAK2/SPATA13/ITGAD/PDGFB/IQGAP1/ACTN1/PIK3R3/PIP4K2A/NCKAP1L/CYFIP1/SSH2/VAV2/PPP1R12A/RGCC/PIKFYVE/VAV1/PIP5K1C/MYH11/ACTR3/ROCK1/WASL/ITGAM/NRAS/RHOA/ITGB8/VAV3/ACTR2/PPP1CB/ARAF/CDC42/AKT2/ITGB2/DIAPH2/RAC1/ITGB1/PIP5K1B/PDGFA/MYL5/ITGB3/LPAR2/CXCL12/ARPC5/FGFR1/APC2/CYFIP2/ITGA11/ITGB4/ITGA10/ITGB7	2.71524259837824
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	18/2577	37/9376	1.77000283170248	CDKN1A/MAP2K1/GADD45B/MAPK1/KRAS/BRAF/RXRA/GADD45A/TPR/GADD45G/TCF7/CCDC6/PPARG/NRAS/TPM3/DDB2/PAX8/CTNNB1	2.88910498429604
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	11/2577	19/9376	2.10640687866348	IDS/GNS/HEXB/HGSNAT/ARSB/HEXA/GUSB/HPSE/SGSH/GALNS/IDUA	2.97196492638368
Organismal Systems	Immune system	hsa04611	Platelet activation	48/2577	126/9376	1.38603396344956	LCP2/GNA13/PIK3R5/ITPR1/PIK3R1/PLCG2/PIK3CB/SYK/TLN1/AKT3/MAPK1/SRC/GNAI3/FCGR2A/BTK/TBXAS1/APBB1IP/VASP/LYN/PIK3R3/PTGS1/PPP1R12A/PIK3CG/MAPK13/RAP1A/GNAQ/ROCK1/SNAP23/PIK3R6/RAP1B/PLCB2/MAPK14/STIM1/RHOA/PLA2G4C/ADCY3/PPP1CB/FYN/P2RX1/RASGRP2/AKT2/PLA2G4A/ITGB1/VWF/GNAS/GP6/ITGB3/PTGIR	2.68571700432305
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	121/2577	362/9376	1.21612993823389	CDKN1A/NR4A1/VEGFA/IL6R/MAP2K1/ITGA5/MCL1/SGK1/PIK3R5/ITGAV/TLR2/NFKB1/BCL2L11/IL3RA/PIK3R1/BCL2/EIF4E/JAK1/DDIT4/GRB2/CREB5/ITGA4/PPP2CA/PIK3AP1/GNB4/ATF4/HSP90AA1/PIK3CB/IFNAR2/IL4R/SYK/HSP90AB1/MDM2/FOXO3/AKT3/PPP2R5C/OSM/MAPK1/IFNAR1/EREG/GNB1/RAF1/CSF3R/YWHAG/RPTOR/GNG7/PHLPP1/KRAS/YWHAQ/PPP2R2D/PPP2R2A/SOS2/RXRA/PDPK1/PDGFB/CDC37/SGK3/PIK3R3/YWHAZ/GYS1/RHEB/PIK3CG/EIF4B/PPP2R5A/TLR4/RPS6KB1/GSK3B/CDKN1B/IL6/PIK3R6/NRAS/RELA/CHUK/PPP2R5E/INSR/ITGB8/THBS1/CREB1/PPP2R1A/AREG/CCND3/IL2RG/CASP9/YWHAH/EFNA2/PRKAA1/CREB3/CSH2/YWHAB/PTEN/AKT2/CSF3/PPP2R1B/IL2RA/LAMB3/PHLPP2/RAC1/ITGB1/VWF/JAK2/PDGFA/TNC/ITGB3/LPAR2/PPP2R3A/GNB5/FGFR1/GNG4/IL7R/GNGT2/ITGA11/MET/ITGB4/ITGA10/THBS3/EPHA2/LPAR3/PPP2R5B/FLT3/CCNE1/ITGB7	2.58184855872075
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	39/2577	99/9376	1.43328512129443	CDKN1A/MAP2K1/HBEGF/PIK3R1/BCL2/GRB2/PIK3CB/MDM2/AKT3/MAPK1/SRC/NOTCH2/NCOA3/RAF1/KRAS/BRAF/SOS2/RB1/PIK3R3/MAPK8/NOTCH1/MAPK13/E2F3/RPS6KB1/CDKN1B/NCOR1/MAPK14/NRAS/ADCY3/MED1/JAG1/ARAF/AKT2/ESR1/SP1/GNAS/SHC3/DLL1/NOTCH4	2.66813574923348
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	75/2577	212/9376	1.2871482856327	SIPA1L1/DOCK4/VEGFA/RASSF5/RAPGEF1/MAP2K3/MAP2K1/LCP2/RALA/RALGDS/FPR1/PIK3R1/MRAS/RAPGEF2/PIK3CB/TLN1/AKT3/MAPK1/SRC/GNAI3/CRK/TIAM1/RAF1/FARP2/SIPA1L2/KRAS/BRAF/APBB1IP/VASP/PDGFB/PIK3R3/PRKCB/FYB1/VAV2/RALB/MAPK13/VAV1/RAP1A/PRKD3/RAPGEF6/GNAQ/RAP1B/ITGAM/PLCB2/MAPK14/NRAS/RHOA/RASGRP3/ADCY3/INSR/THBS1/VAV3/SIPA1L3/EFNA2/RASGRP2/PRKCG/CDC42/AKT2/PRKD2/ITGB2/RAC1/ITGB1/GNAS/PDGFA/CTNNB1/ITGB3/LPAR2/ADORA2B/ADORA2A/CALM1/FGFR1/MET/EPHA2/LPAR3/CNR1	2.60346620662332
Organismal Systems	Digestive system	hsa04978	Mineral absorption	26/2577	61/9376	1.55076750828578	ATP1A1/FTH1/ATP2B1/HMOX1/VDR/ATP1B3/SLC30A1/MT1M/SLC31A1/SLC8A1/TRPM7/SLC11A2/MT2A/MT1X/MT1H/MT1E/MT1A/MT1F/MT1G/TF/SLC8A2/CLCN2/FTL/FXYD2/SLC26A3/ATP1B2	2.65681996742205
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	29/2577	70/9376	1.5073119352514	NFKBIA/PRKAG2/TNFRSF1B/ACSL3/ACSL1/NFKB1/IRS2/STAT3/ACSL5/TNF/NFKBIE/ADIPOR2/ACSL4/AKT3/NFKBIB/RXRA/CPT1A/PTPN11/MAPK8/CAMKK2/SOCS3/RELA/CHUK/PRKAG1/PRKAA1/AKT2/JAK2/TRAF2/PRKAB1	2.62278627681071
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	60/2577	166/9376	1.31506234483919	KCNMA1/RGS2/MAP2K1/GNA13/PIK3R5/IRS2/ITPR1/GNA12/PRKCE/PPIF/ATP1A1/CREB5/MEF2D/ATP2B1/ATP2A2/ATF4/PDE2A/AKT3/MAPK1/GNAI3/NFATC1/RAF1/ATP1B3/VASP/SLC8A1/PPP1R12A/PIK3CG/ADRB2/GNAQ/ROCK1/PIK3R6/PLCB2/NFATC3/RHOA/PPP3R1/ADCY3/INSR/CREB1/PPP1CB/ADRA2B/PPP3CA/CREB3/PDE3B/AKT2/ATP2A3/KCNMB1/KCNMB4/SLC8A2/SRF/CACNA1D/MEF2A/ADORA3/CALM1/ATP2A1/CNGB1/PLN/MEF2B/FXYD2/ADRA2C/ATP1B2	2.5213959836781
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	58/2577	160/9376	1.31889794334497	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-B/HLA-A/HLA-DPA1/HLA-DOA/ITGAV/HLA-DMB/CD58/HLA-DQA2/CD80/HLA-DMA/ITGA4/NECTIN2/ICAM1/HLA-F/HLA-E/HLA-DQB2/JAML/CD22/SDC3/PTPRC/CD86/HLA-C/SDC2/VSIR/SIGLEC1/SDC4/SELL/F11R/CD4/ITGAM/CADM1/CD40/ICOSLG/CD226/ITGB8/ALCAM/ITGB2/SPN/ITGB1/HLA-G/ICAM3/CLDN1/CD274/NECTIN1/CD6/CTLA4/CLDN12/HLA-DOB/ITGB7/NLGN3/CLDN6/CLDN4	2.50472934283846
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	42/2577	110/9376	1.38918404063922	SMAD7/SKI/SKIL/TGIF1/SMAD3/EP300/PPP2CA/ZFYVE16/TNF/TGFB1/ID2/CREBBP/CUL1/SIN3A/MAPK1/TGIF2/SMURF1/SMURF2/TFRC/EMP3/SMAD2/TFDP1/ACVR1/RPS6KB1/ROCK1/NCOR1/RHOA/INHBA/THBS1/PPP2R1A/LEMD3/TGFBR2/BMPR2/HAMP/ACVR1B/PPP2R1B/SP1/TF/CDKN2B/TGFB2/BMP8A/BMP6	2.52770009218698
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	61/2577	170/9376	1.30552169645507	CDKN1A/MAP2K1/NFE2L2/GADD45B/PIK3R1/PLCG2/TXNRD1/GRB2/SMAD3/TGFB1/HMOX1/PIK3CB/AKT3/MAPK1/SMARCA2/ARID2/RAF1/KRAS/BRAF/SOS2/SMARCC1/GADD45A/RB1/SMAD2/PIK3R3/GADD45G/PRKCB/TCF7/WNT2B/CSNK1A1/ARID1A/E2F3/RPS6KB1/GSK3B/GAB1/SMARCE1/NRAS/PHF10/TGFBR2/GSTO2/DDB2/AXIN1/DVL3/PRKCG/PTEN/ARAF/AKT2/ARID1B/FRAT2/SMARCD3/DVL2/CTNNB1/FRAT1/SHC3/ELK1/GSTM3/WNT5B/TGFB2/APC2/WNT5A/MET	2.47486411855458
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	29/2577	71/9376	1.48608218968448	SLC7A5/MAP2K1/GLS/PIK3R1/SCO2/HIF1A/PIK3CB/SLC16A3/AKT3/HK1/MAPK1/RAF1/KRAS/PKM/PIK3R3/HK2/NRAS/PFKP/G6PD/LDHA/PTEN/LDHC/AKT2/PDK1/FGFR1/MET/SIRT3/NTRK3/FLT3	2.53105172809159
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	36/2577	93/9376	1.40838934995681	MAP2K3/MAP2K1/PTK2B/HBEGF/ITPR1/GRB2/ATF4/MAPK1/SRC/RAF1/KRAS/SOS2/MAP3K2/PRKCB/MAP2K4/MAPK8/MAPK13/GNAQ/PLCB2/MAPK14/NRAS/PLA2G4C/MAP3K1/ADCY3/MAP3K4/CAMK2G/PRKCD/CAMK2D/PLD2/CDC42/PLA2G4A/MAP2K7/GNAS/CACNA1D/ELK1/CALM1	2.43664372861069
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	51/2577	140/9376	1.32539497754864	MAP2K1/PRKAG2/GNA13/PIK3R5/ITPR1/PRKCE/SMAD3/MEF2D/MRAS/SPHK1/GNB4/MAP1LC3B/SLC9A1/HDAC4/AKT3/MAPK1/GNAI3/GNB1/RAF1/GNG7/KRAS/SLC8A1/SMAD2/PIK3CG/BECN1/NRF1/RPS6KB1/GNAQ/PIK3R6/PLCB2/NRAS/ADCY3/PIK3C3/PRKAG1/PRKAA1/JAG1/PDE3B/AKT2/PIK3R4/SLC8A2/SERPINE1/MEF2A/CALM1/GNB5/GNG4/GNGT2/PRKAB1/ADCY10/MAP1LC3B2/MEF2B/PLAT	2.38810395549211
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	38/2577	100/9376	1.38256887854094	CXCL3/IL6R/CXCL2/TNFRSF1B/CXCR4/CXCL8/IL10RA/TNF/CXCL1/CCL20/TNFRSF10B/TNFRSF14/TNFRSF10D/CCL21/IL10/IL18/IL6/IL2RG/TNFRSF10A/CCL18/CCR5/TNFSF10/CCR7/IL2RA/CCL14/IL19/CXCL9/CCL8/CXCL5/CXCL12/TNFSF14/CXCL10/TNFRSF10C/CCL3L1/IL20RB/ACKR3/CCL4L2/CCR3	2.36782496262282
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	15/2577	32/9376	1.70547147846333	BCL2L11/PMAIP1/BCL2/BIRC3/BIRC2/BID/MAPK8/BECN1/CASP3/APAF1/CASP8/BIRC6/CYCS/CASP9/DIABLO	2.4609815709302
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	43/2577	116/9376	1.34869468641698	RASSF5/PTK2B/CXCR4/PIK3R1/PLCG2/EZR/ITGA4/ICAM1/PIK3CB/MSN/GNAI3/CTNNA1/VASP/PTPN11/ACTN1/PIK3R3/PRKCB/VAV2/MAPK13/VAV1/RAP1A/F11R/NCF1/ROCK1/RAP1B/ITGAM/MAPK14/RHOA/VAV3/PRKCG/RHOH/CDC42/ITGB2/TXK/RAC1/ITGB1/CTNNB1/CLDN1/MYL5/CXCL12/CLDN12/CLDN6/CLDN4	2.32642554325983
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	55/2577	154/9376	1.29940684073397	PIK3R5/ATP1A1/BCL2/CREB5/PPP2CA/ATP2B1/SLC9A1/ATP2A2/ATF4/CREM/AKT3/PPP2R5C/MAPK1/GNAI3/ATP1B3/PPP2R2D/PPP2R2A/KCNQ1/SLC8A1/PIK3CG/MAPK13/ADRB2/PPP2R5A/KCNE1/GNAQ/RPS6KA5/PIK3R6/PLCB2/POPDC2/MAPK14/ADCY3/PPP2R5E/CREB1/PPP2R1A/PPP1CB/TPM3/CAMK2G/CAMK2D/CREB3/AKT2/ATP2A3/TPM4/PPP2R1B/TPM2/SLC8A2/GNAS/CACNA1D/PPP2R3A/CALM1/ATP2A1/PPP2R5B/PLN/FXYD2/CACNB1/ATP1B2	2.30637460286775
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	27/2577	67/9376	1.46619637551474	MAP2K1/ITPR1/EP300/RPS6KA3/CREBBP/ATF4/MAPK1/RAF1/KRAS/BRAF/PRKCB/RAP1A/GNAQ/RPS6KA1/RAP1B/PLCB2/NRAS/PPP3R1/PPP1CB/CAMK2G/PPP3CA/CAMK2D/RPS6KA2/PRKCG/ARAF/CALM1/GRIN2D	2.35762705064177
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	51/2577	142/9376	1.30672744265359	VEGFA/SQSTM1/ITGAV/THBD/NFE2L2/NFKB1/IL1B/PIK3R1/BCL2/ICAM1/TNF/IL1A/HMOX1/HSP90AA1/PIK3CB/HSP90AB1/AKT3/SRC/ARHGEF2/SDC2/PDGFB/PIK3R3/DUSP1/MAP2K4/MAPK8/ACVR1/MAPK13/SDC4/NCF1/MAPK14/RELA/RHOA/CHUK/MAP3K5/GSTO2/BMPR2/TXN/IL1R2/PRKAA1/CTSL/AKT2/MAP2K7/RAC1/PDGFA/TRPV4/CTNNB1/ITGB3/MEF2A/GSTM3/CALM1/PLAT	2.26736896397635
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	35/2577	93/9376	1.36926742356912	PTPN1/SMAD3/EP300/NECTIN2/CREBBP/MAPK1/SRC/CTNNA1/FARP2/SMURF1/SMURF2/WAS/BAIAP2/IQGAP1/ACTN1/TCF7/SNAI1/RAP1A/CSNK2B/ROCK1/WASL/RAP1B/RHOA/INSR/PTPRJ/TGFBR2/FYN/SORBS1/CDC42/RAC1/CTNNB1/MYL5/NECTIN1/FGFR1/MET	2.20322383998281
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	29/2577	75/9376	1.40682447290131	CDKN1A/PMAIP1/PIK3R1/BCL2/BIRC3/BIRC2/ERCC1/PIK3CB/MDM2/AKT3/BID/REV3L/MAPK1/PDPK1/SLC31A1/PIK3R3/TOP2B/CASP3/APAF1/CASP8/MLH1/CYCS/MAP3K5/GSTO2/CASP9/AKT2/POLH/FAS/GSTM3	2.17767570914684
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	76/2577	226/9376	1.22351228189464	NFKBIA/MAP2K1/PDE4B/NFKB1/PIK3R1/PDE4A/PAK1/ATP1A1/CREB5/EP300/ATP2B1/SLC9A1/CREBBP/ATP2A2/PIK3CB/AKT3/MAPK1/GNAI3/NFATC1/TIAM1/RAF1/ATP1B3/BRAF/PIK3R3/MAPK8/VAV2/PPP1R12A/VAV1/RAP1A/ADRB2/PDE4C/ROCK1/RAP1B/POPDC2/ACOX1/RELA/RHOA/ADCY3/HCAR3/CREB1/VAV3/HCAR2/PPP1CB/CAMK2G/CAMK2D/CREB3/PLD2/ABCC4/PDE3B/AKT2/ATP2A3/PTGER2/ACOX3/RAC1/GNAS/FFAR2/SUCNR1/CACNA1D/ADORA2A/GABBR1/CALM1/OXTR/HCN2/GHRL/ATP2A1/CNGB1/SSTR2/PLN/ADCY10/GIPR/CNGA4/FXYD2/PTGER3/CRH/ATP1B2/GRIN2D	2.09394558632795
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	42/2577	116/9376	1.31732969370961	GLUD1/OGDH/HK1/PKM/PGD/TPI1/ACAT2/SDS/ADPGK/GPI/SDSL/HK2/ACO2/CAT/TALDO1/TKT/ACOX1/PGK1/DLST/ME1/SUCLG2/PCCA/PFKP/G6PD/ACSS2/ACOX3/ACO1/IDNK/GOT2/TKFC/ENO1/PC/ENO3/DLAT/MMUT/GOT1/AMT/ALDH6A1/TKTL1/GPT2/ENO2/ALDOC	2.11716419503461
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	38/2577	104/9376	1.32939315244321	CHKA/LPCAT1/GPCPD1/PLA2G6/SAMD8/LPIN2/AGPAT4/DGKD/PGS1/LPIN1/GPAT4/SGMS2/PCYT1A/AGPAT3/GPD2/LPCAT3/PTDSS1/MBOAT7/GPAT3/ETNK1/PISD/PNPLA6/LPCAT2/DGKA/PLA2G4C/CDS2/PLD3/CHPT1/PLD4/AGPAT1/SELENOI/PLD2/PLA2G4A/PLA1A/DGKE/PNPLA7/DGKG/ACHE	2.079528380002
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	97/2577	298/9376	1.18429160383673	CXCL3/IL6R/CXCL2/TNFRSF1B/CSF2RA/CXCR4/CXCL8/IL1B/IL3RA/RELT/TNFSF13B/TNFSF8/IL10RA/TNF/TGFB1/CXCL16/CXCL1/IL13RA1/IL1A/CCL20/IFNAR2/TNFRSF10B/IL4R/OSM/IFNAR1/IL1RAP/TNFRSF14/CSF3R/IL15/TNFRSF10D/CCL21/RELL1/TNFSF13/IFNGR2/IL10/ACVR1/IL18/CD4/TNFSF9/IFNGR1/IL6/CD40/IL17RA/INHBA/TNFRSF12A/TGFBR2/IL2RG/BMPR2/TNFRSF10A/IL1R2/CLCF1/CCL18/CCR5/CSH2/TNFRSF21/TNFSF10/CSF3/IL15RA/CCR7/IL1RL2/ACVR1B/IL2RA/IL21R/IL12RB1/IL23A/CCL14/TNFSF15/IL19/FAS/CXCL9/TNFRSF8/GDF11/CCL8/CXCL5/CXCL12/TNFSF14/CRLF2/CSF2/TGFB2/IL7R/CXCL10/BMP8A/BMP6/TNFRSF10C/TNFRSF9/TNFRSF4/CCL3L1/IL20RB/ACKR3/LIF/IL1RL1/CD70/GDF9/CCL4L2/TNFRSF18/CCR3/IL27	1.99039338347471
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	79/2577	238/9376	1.20768400491745	VEGFA/RASSF5/ETS2/MAP2K1/REL/RALA/RALGDS/ABL2/NFKB1/GAB2/PIK3R1/TBK1/PLCG2/PAK1/GRB2/RASA3/MRAS/PLA2G6/GNB4/PIK3CB/RAB5A/AKT3/MAPK1/STK4/TIAM1/GNB1/RAF1/SHOC2/GNG7/KRAS/SOS2/PAK2/PTPN11/RALGAPA1/PDGFB/PIK3R3/PRKCB/MAPK8/RALB/RAP1A/GAB1/RAP1B/NRAS/RELA/RHOA/CHUK/RALBP1/RASGRP3/PLA2G4C/INSR/KSR1/BRAP/RAB5B/ABL1/EFNA2/RASGRP2/HTR7/PRKCG/PLD2/CDC42/AKT2/PLA2G4A/PLA1A/RASAL3/RAC1/PDGFA/SHC3/ELK1/CALM1/GNB5/RASGRF1/FGFR1/GNG4/GNGT2/MET/SYNGAP1/EPHA2/FLT3/RIN1	1.99795765075352
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	52/2577	150/9376	1.2612909067391	CDKN1A/MAP2K1/GADD45B/PIK3R1/BCL2/GRB2/SMAD3/TGFB1/PIK3CB/AKT3/MAPK1/RAF1/CTNNA1/KRAS/BRAF/SOS2/RXRA/GADD45A/RB1/SMAD2/PIK3R3/GADD45G/TCF7/WNT2B/CSNK1A1/E2F3/RPS6KB1/GSK3B/CDKN1B/GAB1/MLH1/NRAS/TGFBR2/DDB2/AXIN1/DVL3/ARAF/AKT2/FRAT2/DVL2/ABCB1/CTNNB1/FRAT1/SHC3/JUP/WNT5B/CDKN2B/TGFB2/APC2/WNT5A/MET/CCNE1	1.98601958644056
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	16/2577	38/9376	1.53193227539162	SGK1/PIK3R1/ATP1A1/PIK3CB/MAPK1/ATP1B3/KRAS/PDPK1/PIK3R3/PRKCB/INSR/NEDD4L/PRKCG/FXYD2/KCNJ1/ATP1B2	2.02274684599854
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	20/2577	50/9376	1.45533566162204	TLR2/CXCL8/IL1B/ICAM1/TNF/TGFB1/MYD88/SDC2/IL10/IL18/TLR4/IL6/CD40/THBS1/CSF3/ITGB2/TGFB2/MET/THBS3/CD81	1.98741832001011
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	54/2577	158/9376	1.24348300201883	CDKN1A/GADD45B/SMAD3/EP300/PPP2CA/TGFB1/MAD1L1/CREBBP/CUL1/WAPL/MDM2/PPP2R5C/YWHAG/STAG2/YWHAQ/CDC14A/CCNH/GADD45A/SMC1A/RB1/RAD21/NIPBL/SMAD2/GADD45G/YWHAZ/TFDP1/ESCO1/PPP2R5A/E2F3/GSK3B/CDKN1B/DBF4/FZR1/ZBTB17/PPP2R5E/ANAPC5/PPP2R1A/CCND3/TFDP2/ABL1/YWHAH/YWHAB/STAG1/PPP2R1B/CDK7/WEE1/CDKN2B/DBF4B/TGFB2/PPP2R5B/SMC1B/ANAPC2/CCNE1/ORC1	1.90019935443512
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	10/2577	21/9376	1.73254245431195	DSE/CHSY1/CHST11/CSGALNACT2/XYLT1/CHST15/CHST13/UST/CHST12/CHST7	2.06890656412727
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	46/2577	133/9376	1.25837294050026	ITPR1/CREB5/GNAL/PPP2CA/GNB4/ATF4/AKT3/PPP2R5C/GNAI3/GNB1/GNG7/PPP2R2D/PPP2R2A/KIF5B/PRKCB/ARRB2/MAPK8/MAPK13/GSK3A/PPP2R5A/GSK3B/GNAQ/PLCB2/MAPK14/PPP2R5E/CREB1/PPP2R1A/PPP1CB/CAMK2G/PPP3CA/CAMK2D/PRKCG/CREB3/AKT2/PPP2R1B/GNAS/CACNA1D/PPP2R3A/CALM1/GNB5/GNG4/GNGT2/PPP2R5B/MAOB/SLC6A3/SLC18A2	1.84750957864195
Organismal Systems	Nervous system	hsa04730	Long-term depression	23/2577	60/9376	1.39469667572112	MAP2K1/GNA13/ITPR1/GNA12/PPP2CA/MAPK1/GNAI3/RAF1/KRAS/BRAF/LYN/PRKCB/GNAQ/PLCB2/NRAS/PLA2G4C/PPP2R1A/PRKCG/ARAF/PLA2G4A/PPP2R1B/GNAS/CRH	1.88818559806158
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	15/2577	36/9376	1.51597464752296	B4GALT5/ST3GAL1/GALNT2/GALNT6/GALNT7/C1GALT1/GALNT11/ST6GALNAC3/GALNT10/GCNT1/GALNT4/GALNT3/GALNT15/ST6GALNAC2/GALNT12	1.90953007199825
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	35/2577	99/9376	1.28628151911039	ITGA5/PRKAG2/ITGAV/LMNA/ITGA4/TNF/TGFB1/ATP2A2/SLC8A1/EMD/SNTB1/IL6/ITGB8/PRKAG1/TPM3/PRKAA1/DES/ATP2A3/SSPN/TPM4/TPM2/ITGB1/SLC8A2/CACNA1D/ITGB3/DAG1/TGFB2/ITGA11/ATP2A1/PRKAB1/ITGB4/ITGA10/MYBPC3/CACNB1/ITGB7	1.76289911179351
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	30/2577	83/9376	1.31506234483919	NFKBIA/NFKB1/IL1B/TBK1/RIPK1/ADAR/NLRP3/CGAS/IRF7/G3BP1/NFKBIB/SAMHD1/IL18/DNASE2/CASP3/IL6/CASP8/MLKL/RELA/POLR3E/CHUK/POLR3C/GSDME/PCBP1/IKBKE/MEFV/CXCL10/AIM2/ZBP1/CCL4L2	1.77491641288509
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	13/2577	31/9376	1.52575512911988	HADHA/ALDH2/CNDP2/ACOX1/ALDH3A2/DPYD/SMOX/ACOX3/ABAT/DPYS/UPB1/ALDH6A1/CNDP1	1.80507411818535
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	28/2577	78/9376	1.30607046555824	ITGA5/SEPTIN6/PIK3R1/PIK3CB/DNM2/SRC/ARHGAP10/CRK/CTNNA1/CD2AP/HCLS1/PIK3R3/SEPTIN9/ACTR3/CBL/WASL/GAB1/SEPTIN2/RHOA/ACTR2/ELMO1/CDC42/RAC1/ITGB1/CTNNB1/SHC3/ARPC5/MET	1.67106861041366
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	40/2577	117/9376	1.24387663386499	GATAD2A/BAZ1A/GATAD2B/SMARCA5/SMARCA2/ARID2/INO80D/INO80/EP400/YY1/TRRAP/SMARCC1/CHD4/EPC2/MBD2/CHD3/EPC1/BICRAL/SS18/RBBP4/SRCAP/ARID1A/BCL7B/POLE3/BPTF/CHRAC1/SMARCE1/SS18L1/PHF10/MORF4L2/RUVBL2/UCHL5/PHF6/BAZ2B/ARID1B/SMARCD3/MORF4L1/ACTR8/NFRKB/BICRA	1.63418570690401
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	18/2577	47/9376	1.39340648453174	IRS2/PRKCE/PIK3R1/TNF/PIK3CB/HK1/MAPK1/PKM/PIK3R3/HK2/MAPK8/SOCS1/SOCS3/INSR/SOCS4/PRKCD/CACNA1D/CACNA1G	1.66453611915088
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/2577	20/9376	1.6372526193248	SOAT1/CYP51A1/LIPA/FDFT1/SC5D/SQLE/LSS/HSD17B7/DHCR7	1.75631272283079
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	17/2577	44/9376	1.40572194588493	GTF2A1/GTF2B/CCNH/TAF7/TAF4B/GTF2H1/TAF13/GTF2E2/TAF2/TAF3/TAF5L/GTF2H3/CDK7/TAF8/ERCC3/TAF6L/TAF5	1.66068705287124
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	16/2577	41/9376	1.41983966987516	RBBP8/BRCA2/NBN/RPA2/TOP3A/TOPBP1/BABAM2/UIMC1/POLD3/POLD1/RPA1/BARD1/RAD51B/BLM/RAD54L/RAD51	1.65858817975338
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	15/2577	38/9376	1.43618650817965	UAP1/HK1/HEXB/GNPDA1/HEXA/GPI/NAGK/HK2/UGP2/GFPT1/GNE/PGM1/GNPNAT1/GFPT2/CHIT1	1.6586601800726
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	15/2577	38/9376	1.43618650817965	NAMPT/PNP/NT5C2/SIRT1/NADK/NADSYN1/SIRT7/CD38/BST1/NT5E/SARM1/NADK2/SIRT5/SIRT3/NUDT13	1.6586601800726
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	11/2577	26/9376	1.53929733440793	TCN2/ABCC1/BTD/CUBN/SLC19A2/LMBRD1/SCARB1/SLC19A1/APOA1/APOB/MMACHC	1.69523327801754
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	49/2577	148/9376	1.20458526046419	CDKN1A/MAP2K1/GADD45B/PIK3R1/NFKB2/GRB2/HES1/PIK3CB/AKT3/MAPK1/NOTCH2/NCOA3/RAF1/BRCA2/KRAS/BRAF/SOS2/GADD45A/RB1/PIK3R3/GADD45G/TCF7/WNT2B/CSNK1A1/NOTCH1/E2F3/RPS6KB1/GSK3B/NRAS/DDB2/AXIN1/DVL3/JAG1/PTEN/ARAF/AKT2/ESR1/SP1/FRAT2/DVL2/CTNNB1/FRAT1/SHC3/DLL1/WNT5B/FGFR1/APC2/WNT5A/NOTCH4	1.54444246078507
Human Diseases	Cancer: specific types	hsa05218	Melanoma	26/2577	73/9376	1.29584682199223	CDKN1A/MAP2K1/GADD45B/PIK3R1/PIK3CB/MDM2/AKT3/MAPK1/RAF1/KRAS/BRAF/GADD45A/RB1/PDGFB/PIK3R3/GADD45G/E2F3/NRAS/DDB2/PTEN/ARAF/MITF/AKT2/PDGFA/FGFR1/MET	1.56220187558576
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	34/2577	99/9376	1.24953061856438	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-DPA1/FPR3/HLA-DOA/C5AR1/FPR1/HLA-DMB/HLA-DQA2/HLA-DMA/FCGR2B/C3/ICAM1/PTAFR/HLA-DQB2/FCGR2A/IL10/ITGAM/FCGR1A/C3AR1/FCGR3A/ITGB2/DEFB1/CFH/C1QB/FCAR/DEFA3/FCGR3B/C1QC/HLA-DOB	1.53658995243351
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	19/2577	51/9376	1.35545968484406	ATP6V1H/PLCG2/ATP6V1C1/ERO1A/SLC12A2/ATP6V1A/ATP6V1B2/TJP2/ATP6V1E1/KCNQ1/ATP6V1D/ATP6V0A1/ATP6AP1/ATP6V0D1/ADCY3/ATP6V0A2/GNAS/SEC61A2/KDELR3	1.56700847819727
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	12/2577	30/9376	1.45533566162204	NFKB1/IL1B/TNF/ABCC3/FPGS/ABCC1/IL6/GART/RELA/CHUK/ABCC4/SLC19A1	1.53779955620114
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	47/2577	144/9376	1.18751347389298	ERN1/ITPR1/PIK3R1/PPIF/ATP2A2/PIK3CB/AKT3/ATXN1/GTF2B/PSMD12/WIPI2/RB1CC1/ATXN2L/PSMD1/PSMD14/PIK3R3/NRBF2/PRKCB/PSMA6/MAPK8/PSMC1/XBP1/OPA1/BECN1/ATG2A/ATG101/WIPI1/AFG3L2/GNAQ/PLCB2/CYCS/MAP3K5/ATG14/PIK3C3/ATG13/MCU/PRKCG/ULK1/KCNC3/AKT2/ATP2A3/SP1/PIK3R4/BEAN1/TRAF2/ATP2A1/GRIN2D	1.39600236715061
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	20/2577	56/9376	1.29940684073397	BCL2/CSNK1D/CUL1/CUL3/SMURF1/SMURF2/PTCH2/FBXW11/ARRB2/CSNK1A1/SPOPL/MGRN1/GSK3B/CSNK1G3/IQCE/CSNK1G1/GRK3/MOSMO/GPR161/HHAT	1.38346476567873
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	14/2577	37/9376	1.37666886910193	GLS/GLUL/GLUD1/IL4I1/ASL/ADSL/GFPT1/ASRGL1/ABAT/GOT2/PPAT/GOT1/GFPT2/GPT2	1.41328818849334
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	14/2577	37/9376	1.37666886910193	UAP1/HK1/NANS/GPI/GMDS/NAGK/HK2/UGP2/GFPT1/GNE/PGM1/GNPNAT1/GFPT2/NANP	1.41328818849334
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	45/2577	139/9376	1.17787958224805	MAP2K1/HBEGF/ITPR1/FKBP5/PIK3R1/RARA/BCL2/GRB2/CREB5/HSPA1B/ATF4/HSP90AA1/PIK3CB/HSP90AB1/AKT3/HSPA8/MAPK1/HSPA6/SRC/GNAI3/NCOA3/RAF1/KRAS/CTSD/SOS2/HSPA1A/PIK3R3/FKBP4/GNAQ/PLCB2/NRAS/ADCY3/CREB1/PRKCD/EBAG9/CREB3/AKT2/ESR1/SP1/NCOA2/GNAS/SHC3/GABBR1/CALM1/HSPA1L	1.30073359142363
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	18/2577	50/9376	1.30980209545984	SAT1/P4HA1/SAT2/AMD1/ALDH2/CNDP2/ODC1/ALDH3A2/SMS/SMOX/CKB/GOT2/P4HA2/GOT1/P4HA3/MAOB/CNDP1/AZIN2	1.3522032469433
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	22/2577	63/9376	1.2705311331621	ERCC1/POLR2A/CCNH/XPC/RAD23A/RAD23B/CUL4A/DDB1/RPA2/GTF2H1/POLE3/ERCC5/DDB2/ERCC6/UVSSA/GTF2H3/POLD3/POLD1/CDK7/RPA1/ERCC3/LIG1	1.32636499553092
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	29/2577	86/9376	1.22688180776277	ITGA5/ITGAV/LMNA/ITGA4/ATP2A2/DSC2/CTNNA1/SLC8A1/EMD/TCF7/SNTB1/ITGB8/DES/ATP2A3/SSPN/ITGB1/SLC8A2/CTNNB1/CACNA1D/ITGB3/JUP/DAG1/ITGA11/ATP2A1/ITGB4/ITGA10/ACTN2/CACNB1/ITGB7	1.3012518783722
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	50/2577	157/9376	1.15870673696022	TP53BP2/SMAD7/SMAD3/PPP2CA/CSNK1D/BIRC3/LATS2/BIRC2/TGFB1/ID2/MOB1B/CTNNA1/YWHAG/YWHAQ/PPP2R2D/PPP2R2A/SMAD2/FBXW11/YWHAZ/TCF7/WNT2B/SAV1/GSK3B/LATS1/MOB1A/PPP2R1A/LIMD1/AREG/CCND3/PPP1CB/TGFBR2/BMPR2/YWHAH/AXIN1/DVL3/YWHAB/PPP2R1B/ITGB2/DVL2/SERPINE1/CTNNB1/NKD1/SCRIB/WNT5B/LLGL2/TGFB2/APC2/WNT5A/BMP8A/BMP6	1.23459242555933
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	50/2577	157/9376	1.15870673696022	IL6R/ERN1/PRKAG2/EIF2AK3/NFKB1/CXCL8/BCL2L11/IRS2/IL1B/PIK3R1/DDIT3/TNF/TGFB1/IL1A/ADIPOR2/ATF4/PIK3CB/AKT3/BID/MLXIP/RXRA/UQCRC2/PIK3R3/MAPK8/ITCH/XBP1/MAPK13/GSK3A/SREBF1/PPARG/CASP3/GSK3B/SOCS3/IL6/CASP8/MAPK14/EIF2S1/RELA/CYCS/INSR/MAP3K5/PRKAG1/PRKAA1/CDC42/AKT2/RAC1/FAS/TRAF2/PRKAB1/UQCRHL	1.23459242555933
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	42/2577	130/9376	1.17546341900242	NFKBIA/VEGFA/MAP2K1/NFKB1/PIK3R1/GRB2/CREB5/TGFB1/GNB4/GNA15/ATF4/PIK3CB/AKT3/MAPK1/SRC/GNAI3/GNB1/RAF1/GNG7/KRAS/SOS2/SMAD2/PIK3R3/MAP2K4/ARRB2/MAPK8/MAPK13/PLCB2/MAPK14/NRAS/RELA/ADCY3/CREB1/TGFBR2/CREB3/AKT2/MAP2K7/GNAS/SHC3/GNB5/GNG4/GNGT2	1.24022832583054
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	35/2577	107/9376	1.19011093824232	PRKAG2/ITPR1/FOXO1/CREB5/PPP4R3A/EP300/SIRT1/CREBBP/ATF4/AKT3/PPP4R3B/SIK2/PKM/CPT1A/GYS1/GNAQ/PLCB2/PPP3R1/CREB1/PRKAG1/CAMK2G/PFKP/PHKA2/PPP3CA/CAMK2D/LDHA/PRKAA1/CREB3/PDE3B/LDHC/AKT2/PYGM/GNAS/CALM1/PRKAB1	1.21759506680554
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	41/2577	128/9376	1.16540551028328	AMPD3/PDE4B/ADA2/PDE4A/PNP/PDE7A/ADA/NT5C2/PDE8A/ENTPD1/PDE2A/ADK/LACC1/PAPSS2/RRM2B/PDE1B/AK2/GMPS/PDE4C/GART/DGUOK/ADCY3/ENPP4/ENTPD4/AMPD2/ADSL/PDE6D/FHIT/PDE3B/GMPR/PGM1/NT5E/PPAT/AK4/PDE7B/ENTPD5/PRUNE1/PDE6G/PDE6B/ADCY10/PDE6A	1.15998233253771
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	32/2577	98/9376	1.1880291115282	NR4A1/CAMK1D/ITPR1/PRKCE/ATP1A1/CREB5/NR4A2/ATP2B1/ATF4/PDE2A/LDLR/ATF1/ATP1B3/DAGLB/PRKCB/PRKD3/GNAQ/PLCB2/ADCY3/CREB1/SCARB1/CAMK2G/CAMK2D/PRKCG/CREB3/PRKD2/GNAS/CACNA1D/CACNA1G/CALM1/DAGLA/ATP1B2	1.1519437547453
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	37/2577	115/9376	1.17059607565251	MAP2K1/PIK3R5/ITPR1/PIK3R1/BCL2/CREB5/GNB4/ATF4/PIK3CB/AKT3/MAPK1/GNAI3/GNB1/GNG7/KRAS/KCNQ1/PIK3R3/PRKCB/PIK3CG/GNAQ/PIK3R6/PLCB2/NRAS/ADCY3/CREB1/CAMK2G/FYN/CAMK2D/PRKCG/CREB3/AKT2/JAK2/CACNA1D/GNB5/GNG4/GNGT2/ACHE	1.133207242538
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	25/2577	75/9376	1.21277971801837	ITPR1/ATP1A1/CREB5/ATF4/ATP1B3/ALB/HSPA5/PRKCB/CANX/GNAQ/PLCB2/ADCY3/CREB1/GSR/TTF2/GPX3/TG/PRKCG/CREB3/PAX8/ASGR1/GNAS/DUOX1/FXYD2/ATP1B2	1.13898070099663
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	7/2577	17/9376	1.49813965166975	NRP2/LAMP2/MYH9/TFRC/MYH11/DAG1/PCDH7	1.26555544491979
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	33/2577	102/9376	1.17710972631194	KCNMA1/ITPR1/ATP1A1/ATP2B1/SLC9A1/ATP2A2/SLC12A2/ATP1B3/RAB8A/CA2/KCNQ1/PRKCB/RAP1A/GNAQ/RAP1B/PLCB2/RHOA/RAB11A/ADCY3/TPCN2/PRKCG/CD38/BST1/ATP2A3/RAC1/GNAS/ATP2A1/CPB1/CELA2B/CPB2/FXYD2/SLC26A3/ATP1B2	1.10720816280982
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	32/2577	99/9376	1.17602881747236	MAP2K3/IL1B/ITPR1/PRKCE/PRKCH/PIK3R1/PLCG2/PLA2G6/PTGER4/PIK3CB/SRC/IL1RAP/PIK3R3/PRKCB/MAPK8/MAPK13/GNAQ/PLCB2/MAPK14/PLA2G4C/ADCY3/PPP1CB/CAMK2G/PRKCD/CAMK2D/PRKCG/PLA2G4A/PTGER2/GNAS/TRPV4/CALM1/ALOX12	1.08397163371352
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	71/2577	233/9376	1.10867845466915	ITGA5/AMPD3/ITGAV/LMNA/ATP1A1/ITGA4/DIAPH1/FMNL1/MYH9/FMNL3/TLN1/PLEC/DSC2/ATP1B3/SDC3/TMOD3/SDC2/SPTAN1/EMD/ACTG2/SNTB1/VIM/ZYX/SUN2/SDC4/MYH11/CSRP1/SYNE1/ITGB8/THBS1/FMNL2/TPM3/TMEM43/AMPD2/CAPZB/INF2/DES/TMOD2/SSPN/TPM4/DIAPH2/MYOM1/TPM2/ITGB1/ENO1/NEB/LMNB1/COL24A1/ENO3/MYL5/FLNC/ITGB3/JUP/MYOM2/CAPN3/DAG1/ITGA11/ITGB4/SYNPO2/ITGA10/THBS3/ACTN2/FBN2/MYBPC2/ENO2/OBSCN/MYBPC3/SPTBN4/ITGB7/ATP1B2/LMOD2	1.03418297005825
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	25/2577	76/9376	1.1968220901497	PPARD/PLIN2/ACSL3/ACSL1/GK/UBC/ACSL5/OLR1/ACSL4/HMGCS1/RXRA/CPT1A/SCD/PDPK1/PPARG/APOA2/ACOX1/ME1/ANGPTL4/APOC3/SORBS1/FADS2/ACOX3/APOA1/PLIN5	1.06061920855878
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	141/2577	480/9376	1.06876212650369	MAP2K3/MAP2K1/ERN1/C9orf72/TNFRSF1B/SQSTM1/EIF2AK3/PTGS2/NFKB1/IL1B/ITPR1/PPIF/TBK1/UBC/BCL2/FUS/PRNP/DDIT3/PSEN1/TNF/TUBB4B/DNAH17/CAPN2/MAP1LC3B/IL1A/CHMP2B/ATP2A2/ATF4/ATF6/RAB5A/BID/TANK/MAPK1/ATXN1/UBE2L6/UBE2G1/PSMD12/RAF1/RAB8A/UBE2G2/WIPI2/RB1CC1/KRAS/HSPA5/TUBA1C/TUBB6/BRAF/ATXN2L/UBE2J1/VCP/PSMD1/HTT/PSMD14/APP/UQCRC2/NRBF2/KIF5B/UBA1/SPG11/PRKCB/PSMA6/WNT2B/MAPK8/CSNK1A1/PSMC1/XBP1/BECN1/MAPK13/TUBA4A/ATG2A/CSNK2B/LRRK2/ATG101/RAB1A/WIPI1/CASP3/TARDBP/GSK3B/GNAQ/APAF1/PPID/CAT/IL6/CASP8/PLCB2/ZFYVE1/MAPK14/EIF2S1/NRAS/RELA/PPP3R1/HIP1/CYCS/MAP3K5/DERL1/ATG14/MFN2/PIK3C3/ATG13/CAMK2G/MCU/DNAI2/CASP9/PPP3CA/MFN1/VAPB/GPX3/CAMK2D/AXIN1/DVL3/TUBA1A/PRKCG/OPTN/ARAF/TOMM40L/ULK1/ATP2A3/MAP2K7/TUBB3/FRAT2/RAC1/PIK3R4/SMCR8/DVL2/CTNNB1/FRAT1/CACNA1D/FAS/KLC4/CALM1/WNT5B/TRAF2/APC2/WNT5A/ATP2A1/UQCRHL/MAP1LC3B2/KLC2/SLC6A3/DNAH12/GRIN2D	0.952122563987349
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	43/2577	138/9376	1.13368538858239	MAP2K1/ITPR1/CPEB2/PPP2CA/RPS6KA3/MAD1L1/CUL1/PPP2R5C/MAPK1/YWHAG/YWHAQ/SLK/SMC1A/FBXW11/YWHAZ/SPDYA/MAPK13/PPP2R5A/CPEB4/RPS6KA1/MAPK14/PPP3R1/ADCY3/PPP2R5E/ANAPC5/PPP2R1A/PPP1CB/CAMK2G/PPP3CA/YWHAH/CAMK2D/RPS6KA2/YWHAB/REC8/PPP2R1B/CALM1/AURKA/SPDYE2/PPP2R5B/SMC1B/SPDYE1/ANAPC2/CCNE1	0.97399075333673
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	13/2577	37/9376	1.27833537845179	IL1B/ICAM1/TNF/MYD88/PRKCB/IL10/IL18/GNAQ/IL6/PLCB2/PRKCG/FAS/APOA1	1.04433398954266
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	8/2577	21/9376	1.38603396344956	BCAT1/ALDH2/PPCDC/ALDH3A2/DPYD/VNN1/DPYS/UPB1	1.09026882504308
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	19/2577	57/9376	1.21277971801837	ELOVL5/ACSL3/ACSL1/ACSL5/ACSL4/PPT1/HADHA/CPT1A/SCD/ACAT2/ACAA2/ACOX1/FADS1/ELOVL7/HACD2/FADS2/OXSM/ACOX3/ACADSB	0.991980940473403
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/2577	18/9376	1.41490967102143	ZNF143/TCN2/LMBRD1/HCFC1/MTRR/MMUT/MMACHC	1.08472242046118
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	56/2577	184/9376	1.10732061210373	SEMA4A/CXCR4/PLXNC1/SSH1/PIK3R1/PLCG2/PAK1/EPHB2/DPYSL2/SEMA6B/PIK3CB/MAPK1/SRC/SRGAP2/GNAI3/RAF1/KRAS/LIMK2/SEMA4D/PDPK1/PAK2/PTPN11/PIK3R3/SRGAP1/SSH2/GSK3B/ROCK1/NRAS/NFATC3/RHOA/SRGAP3/PPP3R1/CAMK2G/ABL1/BMPR2/FYN/PPP3CA/EFNA2/CAMK2D/CDC42/RAC1/ITGB1/UNC5B/EPHB6/MYL5/PLXNA3/CXCL12/SEMA3C/WNT5B/WNT5A/RND1/MET/EPHA2/ROBO3/SEMA4C/EPHA4	0.905122522126763
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	18/2577	54/9376	1.21277971801837	HES1/ERCC1/REV3L/BRCA2/REV1/RPA2/TOP3A/MLH1/WDR48/POLH/PMS2/FANCI/RPA1/RMI1/SLX4/BLM/FANCA/RAD51	0.965367972838683
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/2577	31/9376	1.29102357079375	PGD/GPI/RBKS/TALDO1/TKT/PFKP/G6PD/PGM1/IDNK/TKTL1/ALDOC	0.999170690547636
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	33/2577	105/9376	1.14347801984589	ITGA5/ITGAV/LMNA/ITGA4/TNF/TGFB1/ATP2A2/SLC8A1/EMD/SNTB1/ADCY3/ITGB8/TPM3/DES/ATP2A3/SSPN/TPM4/TPM2/ITGB1/SLC8A2/GNAS/CACNA1D/ITGB3/DAG1/TGFB2/ITGA11/ATP2A1/ITGB4/ITGA10/PLN/MYBPC3/CACNB1/ITGB7	0.910200479982279
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	5/2577	12/9376	1.51597464752296	FCGR2B/NPC1/CD46/ASGR1/SLAMF1	1.10105397830533
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	10/2577	28/9376	1.29940684073397	ATP6V1C1/ATP6V1A/CA2/ATP6V1B2/ATP6V1E1/ATP6V1D/ATP6V0A1/ATP6V0D1/SLC12A7/ATP6V0A2	0.976791134907546
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	27/2577	85/9376	1.15570773128809	AMPD3/ADA2/UPP1/PNP/ADA/NT5C2/ENTPD1/ASMTL/ADK/LACC1/RRM2B/TYMP/CMPK2/AK2/GMPS/DGUOK/NT5C3A/ENTPD4/AMPD2/ADSL/GMPR/NT5E/UCK2/AK4/ENTPD5/UCKL1/CTPS1	0.887786908725118
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	47/2577	154/9376	1.11040220935448	CDKN1A/RGS2/MAP2K1/PRKAG2/CAMK1D/PIK3R5/PTGS2/ITPR1/MAPK1/SRC/GNAI3/NFATC1/RAF1/KRAS/PRKCB/CAMKK2/PPP1R12A/PIK3CG/TRPM2/GNAQ/ROCK1/PIK3R6/PLCB2/NRAS/NFATC3/RHOA/PLA2G4C/PPP3R1/ADCY3/PPP1CB/PRKAG1/CAMK2G/PPP3CA/CAMK2D/PRKAA1/PRKCG/RCAN1/CD38/PLA2G4A/GNAS/CACNA1D/ELK1/CALM1/EEF2/OXTR/PRKAB1/CACNB1	0.850444335645314
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	13/2577	38/9376	1.24469497375569	CIITA/ADA/BTK/PTPRC/CD4/TAP2/CD40/TAP1/IL2RG/BLNK/RFX5/DCLRE1C/IL7R	0.930486848220715
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	16/2577	48/9376	1.21277971801837	PIK3R1/ATP1A1/PIK3CB/AKT3/HK1/ATP1B3/PIK3R3/PRKCB/HK2/PLCB2/AKT2/MGAM/SLC2A5/CACNA1D/FXYD2/ATP1B2	0.909864888218407
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	24/2577	75/9376	1.16426852929763	MAT2A/GLUL/BCAT1/PKM/TPI1/SDS/SDSL/ACO2/TALDO1/TKT/PGK1/ASL/PFKP/ACO1/GOT2/ENO1/PC/ENO3/GOT1/TKTL1/GPT2/ENO2/ALDOC/CTH	0.879306948959076
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	44/2577	144/9376	1.11171474151684	MAP2K1/JARID2/SKIL/PIK3R1/STAT3/JAK1/GRB2/SMAD3/ID2/PIK3CB/AKT3/MAPK1/PCGF5/RAF1/KRAS/SMAD2/PIK3R3/TCF7/WNT2B/ACVR1/MAPK13/KAT6A/REST/GSK3B/RIF1/MAPK14/NRAS/INHBA/ZFHX3/BMPR2/AXIN1/DVL3/AKT2/ACVR1B/KLF4/DVL2/JAK2/CTNNB1/HESX1/WNT5B/FGFR1/APC2/WNT5A/LIF	0.831695132970164
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	12/2577	35/9376	1.24743056710461	PFKFB3/HK1/TPI1/GMDS/HK2/PFKFB4/ENOSF1/PFKP/HSD17B14/TKFC/SORD/ALDOC	0.902840460382425
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	47/2577	155/9376	1.10323832413284	CDKN1A/NR4A1/MAP2K1/ITPR1/AHR/CREB5/PDE8A/ATF4/LDLR/MAPK1/GNAI3/USP8/BRAF/RB1/TCF7/WNT2B/RAP1A/E2F3/GSK3B/GNAQ/RBBP5/CDKN1B/RAP1B/PLCB2/ADCY3/CREB1/NCEH1/SCARB1/CAMK2G/CAMK2D/AXIN1/DVL3/CREB3/SP1/RASD1/DVL2/GNAS/CTNNB1/ARMC5/CACNA1D/CACNA1G/WNT5B/CDKN2B/APC2/WNT5A/CCNE1/CRH	0.797880977369668
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	17/2577	52/9376	1.1894570311334	SOAT1/NPC1/LDLR/ABCA1/MYLIP/VAPA/LIPA/APOA2/ANGPTL4/NCEH1/STARD3/SCARB1/APOC2/VAPB/APOC3/APOA1/APOB	0.843396110296576
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/2577	32/9376	1.25067908420644	HADHA/ACOX1/SUCLG2/PCCA/LDHA/ACSS2/LDHC/ACOX3/ABAT/MMUT/ALDH6A1	0.874474199571458
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	14/2577	42/9376	1.21277971801837	KYNU/KMO/HADHA/ACAT2/ALDH2/IL4I1/CAT/DLST/ALDH3A2/CYP1B1/DHTKD1/KYAT1/AANAT/MAOB	0.850827077484695
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	19/2577	59/9376	1.17166854113639	UPP1/NT5C2/ENTPD1/ASMTL/RRM2B/TYMP/CMPK2/DPYD/NT5C3A/ENTPD4/NT5E/UCK2/CDADC1/DPYS/UPB1/ENTPD5/UCKL1/CTPS1/DHODH	0.814327312824262
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	16/2577	49/9376	1.1880291115282	B4GALT1/GALNT2/LFNG/GALNT6/GALNT7/C1GALT1/GALNT11/OGT/EOGT/GALNT10/GXYLT1/GALNT4/GALNT3/GALNT15/POMT2/GALNT12	0.812404784533645
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	107/2577	368/9376	1.05788665620624	MAP2K3/ERN1/C9orf72/TNFRSF1B/SQSTM1/EIF2AK3/TBK1/NXF1/BCL2/FUS/DDIT3/RANBP2/TNF/UBQLN1/TUBB4B/NUP98/DNAH17/MAP1LC3B/CHMP2B/ATF4/NUP153/ATF6/RAB5A/BID/TANK/PSMD12/SETX/RAB8A/WIPI2/RB1CC1/HSPA5/TUBA1C/TUBB6/ATXN2L/VCP/PSMD1/POM121/PSMD14/SEC13/NUP58/TPR/UQCRC2/NRBF2/KIF5B/SPG11/NXT1/NUP62/PSMA6/HNRNPA2B1/PSMC1/XBP1/BECN1/MAPK13/TUBA4A/ATG2A/NUP210L/ATG101/RAB1A/WIPI1/CASP3/TARDBP/POM121C/APAF1/CAT/MAPK14/ANXA11/EIF2S1/NUP54/HNRNPA3/PPP3R1/CYCS/MAP3K5/NUP50/DERL1/ATG14/PIK3C3/NCBP1/ATG13/MCU/DNAI2/NXT2/CASP9/PPP3CA/SRSF3/VAPB/GPX3/TUBA1A/NUP88/OPTN/TOMM40L/ULK1/NUP93/TUBB3/SRSF7/RAC1/PIK3R4/SMCR8/HDAC6/KLC4/ANG/TRAF2/NUP210/UQCRHL/MAP1LC3B2/KLC2/DNAH12/GRIN2D	0.697442664676421
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	6/2577	16/9376	1.36437718277066	ST3GAL1/GLA/HEXB/HEXA/GBGT1/A3GALT2	0.898035629397549
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	20/2577	63/9376	1.15502830287464	EZH2/KMT2E/DOT1L/PRDM2/SETDB2/HADHA/SETD2/ACAT2/ALDH2/EHMT1/KMT2C/ASH1L/NSD3/DLST/ALDH3A2/NSD2/SETD1B/SETD1A/PIPOX/DHTKD1	0.76007560329951
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	12/2577	36/9376	1.21277971801837	HK1/GBE1/GPI/GYS1/HK2/GYG1/UGP2/MGAM/PYGM/PGM1/AGL/PGM2L1	0.787459756439487
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	17/2577	53/9376	1.16701444564032	ATP1A1/ATP2B1/DNM2/VDR/ATP1B3/SLC8A1/PRKCB/GNAQ/PLCB2/RAB11A/AP2A2/PRKCG/ESR1/SLC8A2/GNAS/FXYD2/ATP1B2	0.750644757679615
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	14/2577	43/9376	1.18457553852957	ACSL3/ACSL1/ACSL5/ACSL4/HADHA/CPT1A/ACAT2/ALDH2/ACAA2/ACOX1/ALDH3A2/ACOX3/CYP2U1/ACADSB	0.746823656006215
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	8/2577	23/9376	1.26550927097569	IDI1/HMGCS1/ACAT2/NUS1/PDSS1/HMGCR/FNTB/RCE1	0.784853262635945
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/2577	20/9376	1.27341870391929	UAP1/CYB5R4/NANS/GMDS/UGP2/GNE/NANP	0.753561042812433
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	17/2577	54/9376	1.14540306701735	MAT2A/BCAT1/AMD1/LACC1/SDS/SDSL/GCLC/AHCYL1/IL4I1/GCLM/SMS/LDHA/LDHC/GOT2/GOT1/KYAT1/CTH	0.659684416157309
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	33/2577	110/9376	1.09150174621653	MAP2K1/STK10/PIK3R1/CPEB2/RPS6KA3/MAD1L1/HSP90AA1/PIK3CB/HSP90AB1/AKT3/MAPK1/GNAI3/RAF1/KRAS/BRAF/PIK3R3/MAPK8/SPDYA/MAPK13/CPEB4/RPS6KA1/MAPK14/FZR1/ADCY3/ANAPC5/RPS6KA2/ARAF/PDE3B/AKT2/AURKA/SPDYE2/SPDYE1/ANAPC2	0.594292026895324
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	14/2577	44/9376	1.15765336719935	MAN2A1/B4GALT1/STT3B/MAGT1/HEXB/MGAT1/ALG13/MGAT4A/HEXA/RPN1/MAN2A2/HEXD/ALG2/ALG11	0.645301316344804
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/2577	27/9376	1.21277971801837	ELOVL5/SCD/ACOX1/FADS1/ELOVL7/HACD2/FADS2/ACOX3/ACOT7	0.681631823273312
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	20/2577	65/9376	1.11948897047849	GK/GLA/LPIN2/AGPAT4/DGKD/LPIN1/MGLL/GPAT4/AGPAT3/ALDH2/GPAT3/PNPLA2/DGKA/ALDH3A2/AGPAT1/DGAT1/DGKE/MOGAT1/TKFC/DGKG	0.595122898814879
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	20/2577	65/9376	1.11948897047849	MAP2K1/ITPR1/PIK3R1/PIK3CB/AKT3/MAPK1/RAF1/KRAS/PIK3R3/PRKCB/ARRB2/GNAQ/PLCB2/NRAS/PRKCG/AKT2/CACNA1D/CACNA1G/GABBR1/HCN2	0.595122898814879
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	111/2577	388/9376	1.04086506726834	MAP2K1/ERN1/EIF2AK3/PTGS2/NFKB1/IRS2/IL1B/ITPR1/PIK3R1/PPIF/EIF2AK2/DDIT3/ADAM17/PSEN1/TNF/TUBB4B/CAPN2/IL1A/ATP2A2/ATF4/SLC39A10/ATF6/PIK3CB/AKT3/BID/MAPK1/PSMD12/RAF1/WIPI2/RB1CC1/RTN3/KRAS/TUBA1C/TUBB6/BRAF/RTN4/PSMD1/PSMD14/APP/UQCRC2/PIK3R3/NRBF2/KIF5B/PSMA6/WNT2B/MAPK8/SLC11A2/CSNK1A1/PSMC1/XBP1/BECN1/TUBA4A/ATG2A/SLC39A11/CSNK2B/ATG101/SLC39A8/WIPI1/CASP3/GSK3B/GNAQ/APAF1/PPID/IL6/CASP8/PLCB2/EIF2S1/NRAS/RELA/APH1B/CHUK/PPP3R1/CYCS/INSR/MAP3K5/ATG14/PIK3C3/ATG13/SLC39A9/MCU/CASP9/PPP3CA/AXIN1/IDE/DVL3/TUBA1A/ARAF/ULK1/AKT2/ATP2A3/SLC39A7/MAP2K7/TUBB3/FRAT2/PIK3R4/DVL2/CTNNB1/FRAT1/CACNA1D/FAS/KLC4/CALM1/WNT5B/TRAF2/APC2/WNT5A/ATP2A1/UQCRHL/SLC39A14/KLC2/GRIN2D	0.506123935046841
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	63/2577	217/9376	1.05629201246761	VEGFA/MAP2K1/BCL6/NFKB1/KPNA4/PIK3R1/STAT3/BCL2/GRB2/AHR/CREB5/RPS6KA3/ATF4/HSP90AA1/PIK3CB/HSP90AB1/AKT3/MAPK1/SRC/VDR/GNAI3/NOTCH2/RAF1/KRAS/SOS2/RXRA/STAT5A/RB1/KPNB1/PIK3R3/PRKCB/KPNA3/ARRB2/STAT5B/KPNA1/KPNA6/ADRB2/RPS6KB1/RPS6KA1/KPNA2/NRAS/RELA/PTGES3/ADCY3/CREB1/CCND3/GSTO2/RPS6KA2/CYP1B1/PRKCG/JAG1/CREB3/AKT2/ESR1/KLF4/IKBKE/KLF5/GNAS/JAK2/DLL1/CACNA1D/GSTM3/NR1I3	0.51650310836143
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	15/2577	48/9376	1.13698098564222	BCAT1/HMGCS1/HADHA/ACAT2/ALDH2/ACAA2/IL4I1/ALDH3A2/PCCA/MCCC1/ABAT/AACS/MMUT/ALDH6A1/ACADSB	0.585742806457929
NA	NA	hsa03272	Virion - Hepatitis viruses	15/2577	48/9376	1.13698098564222	CHMP1B/CHMP4B/LAMP2/LDLR/IST1/VPS4B/PDCD6IP/TGOLN2/SLC10A1/SCARB1/CLDN1/CLDN12/CD81/CLDN6/CLDN4	0.585742806457929
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	21/2577	69/9376	1.10732061210373	CREB5/SIRT1/ATF4/PRKCB/FOSB/PPP3R1/CREB1/PPP1CB/CAMK2G/PPP3CA/CAMK2D/PRKCG/CREB3/ARC/GNAS/CACNA1D/CALM1/MAOB/SLC6A3/SLC18A2/GRIN2D	0.550837065908171
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/2577	14/9376	1.29940684073397	ST3GAL1/B4GALT1/B3GNT2/B4GALT4/B3GNT7	0.690179006549588
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	10/2577	31/9376	1.17365779163068	SRP54/HSPA5/SRPRA/SEC63/SRP72/OXA1L/SPCS3/BAG6/IMMP2L/SEC61A2	0.596218976728778
NA	NA	hsa04518	Integrin signaling	45/2577	154/9376	1.06315105150961	ITGAX/VEGFA/ITGA5/ITGAV/PIK3R1/C3/ITGA4/ICAM1/TGFB1/PIK3CB/TLN1/LIMS1/AKT3/SRC/PARVB/PARVG/ITGAD/PDGFB/ACTN1/PIK3R3/GSK3B/ITGAM/ICAM4/FLNA/ITGB8/THBS1/CCND3/CDC42/AKT2/LAMB3/ITGB2/RAC1/ITGB1/VWF/ICAM3/PDGFA/CTNNB1/TNC/ITGB3/ITGA11/MET/ITGB4/ITGA10/THBS3/ITGB7	0.486461768839706
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	14/2577	45/9376	1.13192773681714	ABCG1/ABCA1/ABCC3/ABCC1/TAP2/TAP1/ABCC4/ABCA7/ABCB1/DEFB1/ABCB4/ABCC10/ABCB9/ABCC11	0.546133228694284
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	18/2577	59/9376	1.11000177581342	PTGS2/IRS2/PIK3R1/PIK3CB/AKT3/GNAI3/MGLL/PIK3R3/PTGS1/ABHD5/ADRB2/PNPLA2/ADCY3/INSR/PDE3B/AKT2/GNAS/PTGER3	0.521804693574414
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	39/2577	134/9376	1.05891960453843	KCNMA1/MAP2K1/GNA13/ADM/ITPR1/GNA12/PRKCE/PRKCH/PLA2G6/MYH9/MAPK1/RAF1/BRAF/PRKCB/ACTG2/PPP1R12A/MYH11/GNAQ/ROCK1/PLCB2/RHOA/PLA2G4C/ARHGEF11/ADCY3/PPP1CB/PRKCD/PRKCG/ARAF/PLA2G4A/KCNMB1/KCNMB4/GNAS/CALCRL/CACNA1D/RAMP1/ADORA2B/ADORA2A/CALM1/PTGIR	0.422911570489444
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	26/2577	88/9376	1.07496384097083	ITGAX/PLAUR/C5AR1/THBD/PLAU/C3/SERPING1/CD46/SERPINA1/SERPINB2/CD55/ITGAM/C3AR1/ITGB2/A2M/SERPINE1/VWF/CFH/PROC/F8/C1QB/CPB2/KLKB1/C1QC/F2RL2/PLAT	0.434963074997453
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	20/2577	67/9376	1.08607138927018	HK1/PKM/TPI1/ALDH2/ADPGK/GPI/HK2/PGK1/GALM/ALDH3A2/PFKP/LDHA/ACSS2/LDHC/PGM1/ENO1/ENO3/DLAT/ENO2/ALDOC	0.435276304766717
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	51/2577	178/9376	1.04244548795961	PPARD/FOSL1/CTBP2/SMAD3/EP300/PSEN1/SIRT1/SIAH1/CREBBP/CUL1/NFATC1/CACYBP/TLE3/FBXW11/PRKCB/TCF7/WNT2B/MAPK8/CSNK1A1/TLE4/TBL1X/CSNK2B/GSK3B/SENP2/PLCB2/CHD8/NFATC3/RHOA/PPP3R1/CCND3/CAMK2G/PPP3CA/CAMK2D/AXIN1/DVL3/PRKCG/TBL1XR1/CELSR1/FRAT2/RAC1/DVL2/CCDC88C/CCAR2/CTNNB1/NKD1/FRAT1/WNT5B/APC2/WNT5A/ANKRD6/PORCN	0.351977705689286
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	26/2577	89/9376	1.06288559556666	MAP2K1/ITPR1/GRB2/CSNK1D/TUBB4B/MAPK1/SRC/GNAI3/RAF1/KRAS/TUBA1C/TUBB6/SOS2/MAP3K2/PDGFB/PRKCB/TUBA4A/GNAQ/PLCB2/NRAS/ADCY3/TUBA1A/PRKCG/TUBB3/GNAS/PDGFA	0.366968499204876
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	9/2577	29/9376	1.12913973746538	RASSF2/PAK1/LATS2/MOB1B/RASSF4/SAV1/LATS1/MOB1A/LIMD1	0.428788474816194
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	28/2577	97/9376	1.05024223003652	ITPR1/PER1/GNB4/MAPK1/GNAI3/GNB1/GNG7/PRKCB/PER2/GNAQ/RPS6KA5/PLCB2/PER3/ADCY3/CREB1/CAMK2G/CAMK2D/PRKCG/RASD1/GNAS/CACNA1D/CACNA1G/CALM1/GNB5/GNG4/GNGT2/ADCY10/GRIN2D	0.306213627482631
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	33/2577	115/9376	1.04404514855494	MAP2K1/PTGS2/ITPR1/GNB4/MAPK1/GNAI3/GNB1/RAF1/ALOX5/GNG7/KRAS/BRAF/APP/PTGS1/PRKCB/DUSP1/CASP3/GNAQ/PLCB2/NRAS/PLA2G4C/HTR7/PRKCG/ARAF/PLA2G4A/GNAS/CACNA1D/GNB5/GNG4/GNGT2/ALOX12/MAOB/SLC18A2	0.292575788453598
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	10/2577	33/9376	1.10252701638033	BCAT1/OGDH/ACO2/DLST/ACO1/GOT2/DLAT/DHTKD1/GOT1/GPT2	0.363222247728463
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/2577	19/9376	1.14894920654372	OGDH/DLST/DLAT/DHTKD1/AMT/LIPT1	0.400098576931611
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	67/2577	238/9376	1.02423833328442	NFKBIA/MX1/MX2/IL6R/TRAF3/C5AR1/HBEGF/STAT1/TLR2/NFKB1/CXCL8/IL1B/PIK3R1/TBK1/STAT3/PLCG2/JAK1/TAB2/OAS2/EIF2AK2/ADAR/C3/ADAM17/NLRP3/CGAS/IFIH1/TNF/PIK3CB/IFNAR2/SYK/MAPK1/IFNAR1/TLR7/FCGR2A/MYD88/NFKBIB/OAS3/OAS1/STAT2/PIK3R3/PRKCB/IRAK1/ISG15/IRF9/MAPK8/MAPK13/TRAF6/TLR4/IL6/TYK2/MAPK14/RELA/CHUK/C3AR1/TLR8/PRKCG/CSF3/IKBKE/RPS10-NUDT3/RPS26/VWF/RPS4Y1/CSF2/C1QB/CXCL10/TLR3/C1QC	0.23317714547333
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	13/2577	44/9376	1.07496384097083	POLG2/PARP4/TDG/POLE3/POLG/POLB/APTX/TDP1/POLD3/POLD1/LIG1/OGG1/MUTYH	0.306839404169324
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	13/2577	44/9376	1.07496384097083	DYNC1H1/CREB5/STX4/RAB5A/DYNC1LI1/VAMP2/RAB11A/ADCY3/CREB1/RAB5B/CREB3/ARHGDIB/GNAS	0.306839404169324
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	7/2577	23/9376	1.10732061210373	GLS/GLUL/GLUD1/ASL/GOT2/GOT1/GPT2	0.317242905485623
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/2577	23/9376	1.10732061210373	RPA2/MLH1/POLD3/POLD1/PMS2/RPA1/LIG1	0.317242905485623
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	7/2577	23/9376	1.10732061210373	GLS/ATP1A1/GLUD1/ATP1B3/CA2/FXYD2/ATP1B2	0.317242905485623
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	9/2577	31/9376	1.05629201246761	GLUL/ACAT2/ACO2/CAT/PCCA/ACSS2/ACO1/MMUT/AMT	0.193267262909919
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	4/2577	13/9376	1.11948897047849	XRCC6/DCLRE1C/NHEJ1/POLM	0.265406961853456
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/2577	24/9376	1.06118225326607	XYLT1/HS3ST2/HS3ST1/NDST2/HS6ST1/NDST1/HS3ST3B1	0.184756261635662
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	22/2577	79/9376	1.01320837201535	NAPA/ATP6V1H/ATP6V1C1/STX3/DNM2/ATP6V1A/SLC1A3/ATP6V1B2/ATP6V1E1/VAMP2/ATP6V1D/ATP6V0A1/ATP6V0D1/AP2A2/ATP6V0A2/UNC13B/RAB3A/STXBP1/STX1B/SLC6A3/SLC18A2/SLC6A12	0.0725791285614517
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	28/2577	101/9376	1.00864847835191	MAP2K1/EP300/CREBBP/MAPK1/GNAI3/RAF1/KRAS/PRKCB/TCF7/WNT2B/GSK3B/GNAQ/PLCB2/NRAS/ADCY3/CREB1/CAMK2G/CAMK2D/DVL3/PRKCG/CREB3/MITF/DVL2/GNAS/CTNNB1/CALM1/WNT5B/WNT5A	0.0537977060111292
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/2577	17/9376	1.07009975119268	TXNRD1/PAPSS2/SEPHS2/KYAT1/CTH	0.178092873177321
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	5/2577	17/9376	1.07009975119268	GLUL/GLUD1/CA2/CA5B/CA13	0.178092873177321
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	23/2577	83/9376	1.00821446437672	SOD2/ACSL3/ACSL1/ACSL5/ACSL4/PHYH/AGPS/DHRS4/CAT/ACOX1/FAR1/FAR2/PEX19/HACL1/MPV17L2/ACOX3/PEX13/PIPOX/NUDT19/PEX5/PAOX/NUDT13/DECR2	0.0462765160106113
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	21/2577	76/9376	1.00533055572575	ITPR1/ATP1A1/EZR/SLC9A1/GNAI3/ATP1B3/CA2/KCNQ1/PRKCB/GNAQ/PLCB2/ADCY3/CAMK2G/CAMK2D/PRKCG/GNAS/CALM1/KCNJ15/SSTR2/KCNJ1/ATP1B2	0.0287248742797384
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/2577	32/9376	1.023282887078	B4GALT1/GLA/HK1/HK2/GALM/UGP2/PFKP/MGAM/PGM1	0.081220513892086
Human Diseases	Substance dependence	hsa05032	Morphine addiction	25/2577	91/9376	0.999543723641512	PDE4B/PDE4A/PDE7A/PDE8A/GNB4/PDE2A/GNAI3/GNB1/GNG7/PRKCB/ARRB2/PDE1B/PDE4C/ADCY3/GRK6/GRK3/PRKCG/PDE3B/GNAS/GABBR1/GNB5/PDE7B/GNG4/GNGT2/GRK4	-0.00269263840498661
Genetic Information Processing	Transcription	hsa03040	Spliceosome	66/2577	243/9376	0.988190881348299	FUS/HNRNPC/HSPA1B/EIF4A3/RBM22/TRA2B/PRPF40A/SF3B1/HSPA8/HSPA6/ACIN1/SNIP1/WBP11/DDX5/SRSF2/SF3B2/CTNNBL1/PRPF38B/CWC25/DHX15/HNRNPU/SLU7/SRSF10/HSPA1A/SNW1/HNRNPM/BCAS2/SRSF4/RBM25/SRSF5/RBM8A/DHX8/CDC5L/CDC40/PRPF8/DDX46/DDX42/SMNDC1/PRPF6/PRPF3/AQR/HNRNPA3/PRPF4/PQBP1/THOC1/SF3A1/PRPF40B/NCBP1/SART1/SF3A3/DHX38/PCBP1/YJU2/SRSF3/TRA2A/U2AF1/USP39/U2AF1L4/CHERP/SF3A2/RBMXL1/CRNKL1/SRSF7/DHX16/DDX23/HSPA1L	-0.114824409597659
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/2577	18/9376	1.01064976501531	ACSL3/ACSL1/ACSL5/ACSL4/OXSM	0.0278422984364451
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	8/2577	30/9376	0.970223774414694	OGDH/ACLY/ACO2/DLST/SUCLG2/ACO1/PC/DLAT	-0.100562882176439
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	13/2577	49/9376	0.96527365311666	NFKB1/CREB5/ATF4/GNAI3/FOSB/RELA/CREB1/CREB3/GNAS/MAOB/SLC6A3/SLC18A2/GRIN2D	-0.150039800369794
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/2577	15/9376	0.970223774414694	ST3GAL1/HEXB/HEXA/ST6GALNAC3	-0.0710517010464467
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/2577	23/9376	0.949131953231766	CTSA/PRCP/ANPEP/LNPEP/PREP/ATP6AP2	-0.150367451664699
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	17/2577	65/9376	0.951565624906719	NR4A1/ITPR1/CREB5/PDE8A/ATF4/LDLR/GNAQ/PLCB2/ADCY3/CREB1/NCEH1/SCARB1/CREB3/SP1/GNAS/CACNA1D/CACNA1G	-0.241230680893586
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	13/2577	51/9376	0.927419784366987	LPCAT1/PLA2G6/PAFAH1B1/AGPS/PAFAH1B2/LPCAT2/PLA2G4C/PLD3/CHPT1/PLD4/SELENOI/PLD2/PLA2G4A	-0.319962623317503
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/2577	16/9376	0.909584788513776	IL4I1/GOT2/GOT1/MAOB	-0.222835252023034
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/2577	28/9376	0.909584788513776	ELOVL5/PPT1/HADHA/ACAA2/ELOVL7/HACD2/ACOT7	-0.294972475658991
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	30/2577	116/9376	0.940949781221147	GLS/ITPR1/GLUL/HOMER1/GNB4/SLC38A2/MAPK1/GNAI3/GNB1/GNG7/SLC1A3/PRKCB/GNAQ/PLCB2/PLA2G4C/PPP3R1/ADCY3/GRK3/PPP3CA/PRKCG/PLD2/PLA2G4A/GNAS/CACNA1D/GNB5/GNG4/GNGT2/SLC38A1/GRIK5/GRIN2D	-0.393971983668047
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	16/2577	63/9376	0.924022642299709	CDKN1A/GADD45B/PTCH2/GADD45A/GADD45G/TCF7/WNT2B/GSK3B/DDB2/AXIN1/DVL3/DVL2/CTNNB1/WNT5B/APC2/WNT5A	-0.372503181163315
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	22/2577	86/9376	0.930737923130375	KCNMA1/ATP1A1/CREB5/ATF4/ATP1B3/VAMP2/PRKCB/GNAQ/PLCB2/ADCY3/CREB1/CAMK2G/CAMK2D/PRKCG/CREB3/KCNMB1/KCNMB4/GNAS/CACNA1D/RAB3A/FXYD2/ATP1B2	-0.397243871226549
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	13/2577	52/9376	0.909584788513776	PTGS2/LDLR/ALOX5/PLA2G4C/ADCY3/INSR/SCARB1/CYP1B1/PLA2G4A/GNAS/AKR1C3/HSD17B7/BMP6	-0.402496741466571
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	14/2577	56/9376	0.909584788513776	MAN2A1/B4GALT1/STT3B/MAGT1/MGAT1/ALG13/MGAT4A/DHRSX/RPN1/MAN2A2/SRD5A3/ALG2/MGAT5/ALG11	-0.41778023196112
Organismal Systems	Sensory system	hsa04744	Phototransduction	7/2577	29/9376	0.878219795806404	GNB1/SLC24A1/CALM1/PDE6G/CNGB1/PDE6B/PDE6A	-0.40435228570119
Organismal Systems	Endocrine system	hsa04924	Renin secretion	17/2577	69/9376	0.896402400274446	KCNMA1/ITPR1/PTGER4/GNAI3/PDE1B/ADRB2/GNAQ/PLCB2/PPP3R1/CREB1/PPP3CA/CTSB/PDE3B/PTGER2/GNAS/CACNA1D/CALM1	-0.531728218366841
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	22/2577	89/9376	0.89936473471025	GLS/GABARAPL1/GLUL/GNB4/SLC38A2/SRC/GNAI3/GNB1/GNG7/PRKCB/ADCY3/PLCL1/PRKCG/GPHN/ABAT/CACNA1D/GABBR1/GNB5/GNG4/GNGT2/SLC38A1/SLC6A12	-0.587256460524699
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	6/2577	26/9376	0.83961672785887	PLA2G6/ACOX1/PLA2G4C/PLA2G4A/FADS2/ACOX3	-0.504150573021988
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/2577	22/9376	0.826895262285251	ALDH2/CNDP2/ALDH3A2/MAOB/CNDP1	-0.500428388770991
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	11/2577	47/9376	0.85152618499162	PKM/ACAT2/ALDH2/ALDH3A2/ME1/LDHA/ACSS2/LDHC/PC/DLAT/LDHD	-0.628205272528077
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	9/2577	39/9376	0.83961672785887	MAT2A/MTHFD2/AHCYL1/MTHFD2L/MTHFD1L/GART/AMT/DMGDH/CTH	-0.617885524215513
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/2577	27/9376	0.808519812012245	HMGCS1/HADHA/ACAT2/ABAT/AACS/L2HGDH	-0.613399579970978
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/2577	23/9376	0.790943294359805	B4GALT1/B3GALNT2/FKRP/POMT2/POMK	-0.617977808815022
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/2577	10/9376	0.727667830811021	SQOR/PAPSS2	-0.530447241763259
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	8/2577	36/9376	0.808519812012245	RPA2/POLE3/POLD3/POLD1/RPA1/LIG1/POLA2/DNA2	-0.708633997638858
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/2577	28/9376	0.779644104440379	B3GNT5/B4GALT1/ST3GAL6/B3GNT2/GCNT2/B4GALT4	-0.71889367918117
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/2577	15/9376	0.727667830811021	TPK1/AK2/AK4	-0.649836018171977
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	48/2577	195/9376	0.895591176382795	FPR3/MAP2K1/C5AR1/TLR2/NFKB1/FPR1/PIK3R1/PPIF/PLCG2/C3/PIK3CB/SYK/HDAC4/AKT3/MAPK1/SRC/TLR7/RAF1/FCGR2A/AQP9/PIK3R3/PRKCB/CLEC7A/MAPK13/CASP4/TLR4/SIGLEC9/NCF1/ITGAM/PLCB2/CLCN3/FCGR1A/MAPK14/RELA/ATG7/TLR8/FCGR3A/PRKCG/AKT2/HDAC3/ITGB2/RAC1/HDAC6/VWF/AZU1/ITGB3/MPO/FCGR3B	-0.907047104781091
Organismal Systems	Digestive system	hsa04976	Bile secretion	21/2577	90/9376	0.848945802612857	ATP1A1/SLC9A1/LDLR/ATP1B3/CA2/RXRA/ABCC3/AQP9/SLC10A1/ADCY3/NCEH1/SCARB1/ABCC4/SLC22A1/HMGCR/ABCB1/GNAS/ABCB4/SLC51A/FXYD2/ATP1B2	-0.886461828889146
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	56/2577	227/9376	0.897563844172184	SOD2/NFKBIA/VEGFA/MAP2K1/PTPN1/ABL2/NFE2L2/NFKB1/PIK3R1/PPIF/GRB2/AHR/HIF1A/HMOX1/PIK3CB/FOXO3/AKT3/MAPK1/SRC/RAF1/KRAS/BRAF/SOS2/PDPK1/PTPN11/UQCRC2/PIK3R3/MAP2K4/MAPK8/MAPK13/PRKD3/NCF1/CAT/MAP3K14/MAPK14/NRAS/RELA/CHUK/MAP3K5/PTPRJ/PRKCD/GSTO2/ABL1/CYP1B1/PLD2/SLC26A2/PTEN/ARAF/AKT2/PRKD2/MAP2K7/RAC1/GSTM3/AKR1C3/MET/UQCRHL	-0.961833089452951
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	63/2577	254/9376	0.902422703564848	VEGFA/PTK2B/CAMK1D/CXCR4/ITPR1/PPIF/PLCG2/GNAL/SPHK1/ATP2B1/GNA15/ATP2A2/PTAFR/P2RX7/NFATC1/TPCN1/ITPKB/P2RX4/SLC8A1/PDGFB/PRKCB/STIM2/PDE1B/TFEB/ADRB2/GNAQ/PLCB2/STIM1/NFATC3/ORAI2/PPP3R1/ADCY3/ITPKC/CAMK2G/TPCN2/MCU/PHKA2/PPP3CA/P2RX1/CAMK2D/HTR7/PRKCG/CD38/ATP2A3/SLC8A2/GNAS/PDGFA/CACNA1D/CACNA1G/ADORA2B/ADORA2A/CALM1/OXTR/FGFR1/PLCD1/MET/ATP2A1/PLN/NTRK3/CYSLTR2/MCOLN2/PTGER3/GRIN2D	-0.970601442071436
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	37/2577	154/9376	0.874146420130122	KYNU/MAT2A/GCH1/KMO/BCAT1/MTHFD2/FPGS/ALDH2/DHRS3/GCLC/TPK1/GUSB/CMPK2/AK2/GCLM/MTHFD2L/MTHFD1L/PPCDC/ALDH3A2/NADK/UGP2/NADSYN1/PDXK/ADSL/GPHN/ALAS1/RFK/OXSM/COQ7/ALAD/AK4/NADK2/RDH13/CTPS1/DHODH/RDH12/LIPT1	-0.969468498382727
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	13/2577	59/9376	0.801667949198582	PGD/TXNDC12/GCLC/RRM2B/GCLM/ANPEP/ODC1/SMS/GSR/GSTO2/G6PD/GPX3/GSTM3	-0.940808402674826
Organismal Systems	Digestive system	hsa04970	Salivary secretion	21/2577	93/9376	0.821560454141475	KCNMA1/ITPR1/ATP1A1/ATP2B1/SLC9A1/SLC12A2/CST3/ATP1B3/VAMP2/PRKCB/ADRB2/GNAQ/PLCB2/ADCY3/PRKCG/CD38/BST1/GNAS/CALM1/FXYD2/ATP1B2	-1.06465460080752
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	20/2577	89/9376	0.817604304282046	CD44/ITGA5/ITGAV/ITGA4/SDC4/ITGB8/THBS1/LAMB3/ITGB1/VWF/TNC/GP6/ITGB3/DAG1/MEPE/ITGA11/ITGB4/ITGA10/THBS3/ITGB7	-1.06436894038949
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/2577	17/9376	0.642059850715606	AKR1D1/CH25H/CYP7B1	-0.909369698565148
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/2577	17/9376	0.642059850715606	ADO/FMO4/FMO5	-0.909369698565148
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	23/2577	103/9376	0.812444665468615	ATP1A1/SLC3A2/SLC38A2/ATP1B3/SLC36A4/PRCP/KCNQ1/SLC8A1/SLC7A8/SLC16A10/COL18A1/COL23A1/SLC8A2/COL24A1/CPB1/COL13A1/COL12A1/SLC36A3/CELA2B/CPB2/COL7A1/FXYD2/ATP1B2	-1.17830638328109
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	8/2577	41/9376	0.709919834937581	SDS/SDSL/ALAS1/PIPOX/AMT/DMGDH/MAOB/CTH	-1.14596968194191
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/2577	28/9376	0.649703420366983	GCH1/FPGS/GPHN/PCBD2/AKR1C3	-1.14281488270335
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	8/2577	43/9376	0.676900307731182	ABCA1/ACAT2/SCARB1/AGPAT1/DGAT1/GOT2/APOA1/APOB	-1.30731566792111
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	6/2577	34/9376	0.642059850715606	POLR2A/CRCP/POLR3E/POLR3C/POLR1B/POLR1E	-1.28721256021871
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	18/2577	87/9376	0.752759824976918	ATP1A1/SLC9A1/ATP2A2/ATP1B3/SLC8A1/UQCRC2/SLC9A7/TPM3/ATP2A3/TPM4/TPM2/SLC8A2/CACNA1D/ATP2A1/UQCRHL/FXYD2/CACNB1/ATP1B2	-1.42631192788993
Cellular Processes	Cell motility	hsa04814	Motor proteins	44/2577	194/9376	0.825190323600126	DYNC1H1/MYO9B/KIF13B/TUBB4B/DNAH17/MYH9/HOOK3/DYNC1LI1/MYO1G/TUBA1C/TUBB6/KIFC3/MYO5A/KIF5B/ACTG2/KIF1B/KIF13A/MYO1F/TUBA4A/MYH11/DYNLT3/MYO18A/TPM3/DNAI2/MYO1D/CAPZB/TUBA1A/TPM4/KIF20B/TUBB3/TPM2/MYO19/TUBD1/KIF9/MYO5C/MYL5/KIF21B/KLC4/KIF27/MYO1E/CENPE/KIFC2/KLC2/DNAH12	-1.51466997476959
NA	NA	hsa04981	Folate transport and metabolism	5/2577	31/9376	0.586828895815339	ABCC3/FPGS/ABCC1/ABCC4/SLC19A1	-1.41853959236551
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	12/2577	63/9376	0.693016981724781	PTGS2/PLA2G6/ALOX5/TBXAS1/PTGS1/PLA2G4C/PTGES3/PLA2G4A/PTGR2/CYP2U1/AKR1C3/ALOX12	-1.50508196562614
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	62/2577	268/9376	0.841705326684389	ERN1/EIF2AK3/NFE2L2/ITPR1/PPIF/UBC/GNAL/DDIT3/TUBB4B/ATF4/SLC39A10/ATF6/UBE2L6/GNAI3/UBE2G1/PSMD12/UBE2G2/HSPA5/TUBA1C/TUBB6/UBE2J1/PSMD1/PSMD14/UQCRC2/KIF5B/UBA1/PSMA6/DUSP1/MAPK8/SLC11A2/PSMC1/XBP1/TUBA4A/SLC39A11/LRRK2/SLC39A8/CASP3/APAF1/EIF2S1/CYCS/MAP3K5/MFN2/SLC39A9/CAMK2G/MCU/TXN/CASP9/MFN1/CAMK2D/TUBA1A/SLC39A7/TUBB3/GNAS/ADORA2A/KLC4/CALM1/UQCRHL/SLC39A14/MAOB/KLC2/SLC6A3/SLC18A2	-1.618611098137
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	6/2577	36/9376	0.606389859009184	GUSB/FGGY/CRYL1/UGP2/DHDH/SORD	-1.45668087467803
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	8/2577	46/9376	0.632754635487844	FTH1/HMOX1/GUSB/HCCS/ALAS1/ALAD/CP/FTL	-1.53714467014414
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	8/2577	46/9376	0.632754635487844	PSMD12/PSME4/PSMD1/PSMD14/PSMA6/PSMB9/PSMC1/PSME1	-1.53714467014414
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	62/2577	275/9376	0.820280100186969	EIF2AK3/IL1B/ITPR1/PIK3R1/PPIF/CREB5/PRNP/DDIT3/TNF/TUBB4B/HSPA1B/IL1A/ATF4/PIK3CB/HSPA8/MAPK1/HSPA6/STIP1/PSMD12/HSPA5/TUBA1C/TUBB6/HSPA1A/PSMD1/PSMD14/UQCRC2/PIK3R3/KIF5B/PSMA6/MAPK8/PSMC1/NOTCH1/MAPK13/TUBA4A/CSNK2B/CASP3/GSK3B/NCF1/APAF1/IL6/MAPK14/EIF2S1/PPP3R1/CYCS/CREB1/PRKCD/MCU/FYN/CASP9/PPP3CA/TUBA1A/CREB3/TUBB3/RAC1/CACNA1D/KLC4/C1QB/HSPA1L/UQCRHL/KLC2/C1QC/GRIN2D	-1.86225129279461
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	74/2577	323/9376	0.833551385139559	CDKN1A/VEGFA/CD44/MAP2K1/ITGA5/MCL1/EZH2/PTGS2/GLS/NFKB1/BCL2L11/IRS2/PRKCE/PIK3R1/STAT3/PLCG2/BCL2/DDIT4/GRB2/EZR/PLAU/EP300/ST14/SIRT1/HMOX1/CREBBP/PIK3CB/HDAC4/MDM2/SLC7A1/MAPK1/RDX/NOTCH2/CRK/RAF1/RPTOR/KRAS/SOS2/DICER1/FOXP1/PDGFB/ABCC1/PIK3R3/PRKCB/NOTCH1/VIM/SOCS1/SOX4/E2F3/CASP3/ROCK1/CDKN1B/RPS6KA5/NRAS/RHOA/THBS1/BMF/ABL1/BMPR2/EFNA2/CYP1B1/PRKCG/PTEN/ABCB1/PDGFA/TNC/ITGB3/MARCKS/TGFB2/APC2/MET/NOTCH4/ZEB2/CCNE1	-1.87415503191624
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/2577	12/9376	0.303194929504592	COQ7	-1.48693351244192
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	44/2577	205/9376	0.780911818431339	NFKB1/PIK3R1/PPIF/SMAD3/TGFB1/ATP2A2/PIK3CB/AKT3/CTSD/UQCRC2/SMAD2/PIK3R3/PRKCB/MPC1/GYS1/MAPK8/MAPK13/GSK3B/NCF1/PLCB2/MAPK14/RELA/INSR/PDK3/GSR/PPP1CB/CAMK2G/PRKCD/TGFBR2/G6PD/CAMK2D/GFPT1/PRKCG/PTEN/AKT2/ATP2A3/SP1/RAC1/GFPT2/TGFB2/ATP2A1/UQCRHL/PLN/PDK4	-1.95257561572727
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	51/2577	235/9376	0.78959700790132	MAP2K3/PRKAG2/ACSL3/ACSL1/ACSL5/GRB2/CREB5/ZNF516/RPS6KA3/ACSL4/SMARCA2/KDM3B/RPTOR/MGLL/KRAS/KDM3A/SOS2/SMARCC1/CPT1A/UQCRC2/RHEB/ARID1A/MAPK13/FRS2/PPARG/RPS6KB1/RPS6KA1/SMARCE1/MAPK14/PNPLA2/NRAS/ADCY3/COX19/MAP3K5/CREB1/KDM1A/PRKAG1/SLC25A29/RPS6KA2/PRKAA1/CREB3/ARID1B/SMARCD3/GNAS/FGFR1/BMP8A/PRKAB1/COA7/UQCRHL/ADCY10/CNR1	-2.01098724068497
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/2577	31/9376	0.469463116652271	ALDH2/GUSB/ALDH3A2/HSD17B14	-1.82149130618437
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/2577	37/9376	0.49166745325069	IL4I1/FAH/GOT2/GOT1/MAOB	-1.90729960206274
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	28/2577	143/9376	0.712402072122677	HLA-DQA1/HLA-DRB1/HLA-DRB5/HLA-DQB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DOA/HLA-DMB/HLA-DQA2/CD80/HLA-DMA/C3/TNF/HLA-DQB2/RO60/FCGR2A/CD86/ACTN1/IL10/FCGR1A/CD40/FCGR3A/TRIM21/C1QB/FCGR3B/C1QC/HLA-DOB	-2.13354928984186
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/2577	82/9376	0.621179855570383	UPP1/RRM2B/GUSB/TYMP/GMPS/DPYD/GSTO2/UCK2/CDADC1/GSTM3/DPYS/UPB1/UCKL1/MPO	-2.12108945234133
Human Diseases	Substance dependence	hsa05034	Alcoholism	39/2577	191/9376	0.742906947686644	MAP2K1/GRB2/CREB5/GNB4/ATF4/HDAC4/MAPK1/GNAI3/GNB1/RAF1/GNG7/KRAS/BRAF/SOS2/CAMKK2/FOSB/NRAS/CREB1/PPP1CB/CAMKK1/SLC29A3/CREB3/ARAF/SLC29A1/HDAC3/HDAC6/GNAS/SHC3/ADORA2B/ADORA2A/CALM1/GNB5/GNG4/GNGT2/MAOB/SLC6A3/SLC18A2/CRH/GRIN2D	-2.20997708527102
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/2577	30/9376	0.36383391540551	PIGA/MPPE1/PIGG	-2.14851593014841
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/2577	30/9376	0.36383391540551	PLA2G6/PLA2G4C/PLA2G4A	-2.14851593014841
NA	NA	hsa04081	Hormone signaling	43/2577	219/9376	0.714377094175203	GNA13/ITGAV/IRS2/GNA12/PIK3R1/STAT3/GNB4/GNA15/ADIPOR2/PIK3CB/SRC/GNAI3/GNB1/GNG7/STAT5A/PIK3R3/ACVR1/STAT5B/ADRB2/GNAQ/PLCB2/RHOA/ADCY3/INSR/ADRA2B/SLC16A10/HAMP/CSH2/ESR1/GNAS/JAK2/ITGB3/RAMP1/GNB5/OXTR/GHRL/GNG4/GNGT2/UCN2/SSTR2/GIPR/ADRA2C/CRH	-2.63304820687318
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	64/2577	308/9376	0.756018525517943	SOD2/ERN1/RCOR1/ITPR1/PPIF/CREB5/EP300/TUBB4B/DNAH17/CREBBP/SIN3A/PSMD12/POLR2A/WIPI2/RB1CC1/SLC1A3/TUBA1C/TUBB6/PSMD1/HTT/PSMD14/UQCRC2/NRBF2/KIF5B/TAF4B/PSMA6/MAPK8/PSMC1/BECN1/NRF1/TUBA4A/ATG2A/ATG101/PPARG/WIPI1/CASP3/REST/GNAQ/APAF1/CASP8/PLCB2/HIP1/CYCS/MAP3K5/CREB1/AP2A2/ATG14/PIK3C3/ATG13/DNAI2/CASP9/GPX3/TUBA1A/CREB3/ULK1/MAP2K7/SP1/TUBB3/PIK3R4/KLC4/TRAF2/UQCRHL/KLC2/DNAH12	-2.68038254452347
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9/2577	68/9376	0.481544888036705	ALDH1A2/DHRS3/ALDH1A1/DHRS9/DHRS4/DGAT1/CYP2S1/RDH13/RDH12	-2.6415434392959
NA	NA	hsa04082	Neuroactive ligand signaling	37/2577	199/9376	0.676475119095672	GNAL/GNB4/GNAI3/GNB1/OGFRL1/GNG7/SLC1A3/P2RX4/PRKCB/ADRB2/GNAQ/PLCB2/OGFR/ADCY3/P2RY13/P2RY6/ADRA2B/P2RX1/HTR7/PRKCG/GNAS/ADORA2B/ADORA2A/GABBR1/ADORA3/GNB5/P2RY14/GNG4/GNGT2/ACHE/TAC4/GRIK5/ADRA2C/SLC6A3/SLC18A2/GRIN2D/SLC6A12	-2.83990743843495
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8/2577	66/9376	0.441010806552134	DHRS9/SRD5A3/CYP1B1/SRD5A1/AKR1C3/HSD17B7/AKR1D1/CYP7B1	-2.80556843175253
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	25/2577	149/9376	0.610459589606561	PTGS2/ITPR1/GNB4/MAPK1/GNAI3/GNB1/GNG7/MGLL/DAGLB/PRKCB/MAPK8/MAPK13/GNAQ/PLCB2/MAPK14/ADCY3/ABHD6/PRKCG/CACNA1D/GNB5/GNG4/DAGLA/GNGT2/NAPEPLD/CNR1	-2.95077243815258
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/2577	26/9376	0.139936121309812	HES1	-2.70353442406152
NA	NA	hsa04519	Cadherin signaling	80/2577	404/9376	0.720463198822793	NFKBIA/MAP2K3/MAP2K1/PTK2B/NFKB1/LHFPL2/EP300/MRAS/PSEN1/ERBIN/LATS2/CREBBP/FMN1/MAPK1/TAOK3/CDH23/DSC2/RAF1/SHOC2/MOB1B/CTNNA1/YWHAG/KRAS/YWHAQ/MYO1G/VASP/ACTN1/YWHAZ/TCF7/NCKAP1L/WNT2B/SAV1/MAPK8/CYFIP1/CSNK1A1/VAV2/VIM/MAPK13/MYO1F/VAV1/GSK3B/ACTR3/LATS1/MOB1A/ROCK1/TAOK1/MAPK14/NRAS/RELA/APH1B/RHOA/CHUK/VAV3/LIMD1/ACTR2/PPP1CB/MYO1D/YWHAH/AXIN1/DVL3/YWHAB/DES/CDC42/CELSR1/CDH13/RAC1/DVL2/CTNNB1/JUP/ARPC5/MYO1E/WNT5B/FGFR1/APC2/WNT5A/CYFIP2/MET/ANKRD6/TMC4/PCDH7	-3.53594391669108
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	27/2577	183/9376	0.53680413748354	TCOF1/NXF1/NOP58/GTPBP4/NXT1/XPO1/XRN2/CSNK2B/GNL2/UTP18/GNL3/REXO1/LSG1/XRN1/UTP6/EFL1/DKC1/GNL3L/RIOK1/NXT2/FCF1/HEATR1/NAT10/UTP14A/WDR75/RMRP/UTP15	-3.89566777706379
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/2577	41/9376	0.0887399793671976	GRIN2D	-3.5999578109253
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/2577	73/9376	0.249201311921582	GSTO2/GSTM3/FMO4/FMO5/MAOB	-3.96454864988966
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/2577	70/9376	0.207905094517434	PTGS2/GSTO2/CYP1B1/GSTM3	-4.09510501069099
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/2577	79/9376	0.230274630003488	GSTO2/CYP1B1/CYP2S1/DHDH/GSTM3	-4.22958987838051
NA	NA	hsa04382	Cornified envelope formation	29/2577	217/9376	0.48622965653271	PPP2CA/UGCG/ST14/PPP2R5C/PLEC/PPP2R2D/PPP2R2A/KDSR/ABHD5/PPP2R5A/PPP2R5E/PPP2R1A/SPTLC3/DST/PPP2R1B/LAMB3/BLMH/PADI2/CLDN1/GBA2/PPP2R3A/JUP/TCHH/ITGB4/PPP2R5B/CLDN12/COL7A1/CLDN6/CLDN4	-4.71406097867723
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	14/2577	138/9376	0.369106870701242	ATP6V1H/ATP6V1C1/ATP6V1A/ATP6V1B2/ATP6V1E1/UQCRC2/ATP6V1D/ATP6V0A1/ATP6AP1/ATP6V0D1/CYCS/LHPP/ATP6V0A2/UQCRHL	-4.59649390854687
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/2577	86/9376	0.211531346165994	PDE1B/PLCB2/GABBR1/PKD2L1/TAS1R1	-4.5221621202521
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	52/2577	370/9376	0.511334151380717	FPR3/C5AR1/ADM/FPR1/C3/PTGER4/PTAFR/P2RX7/OGFRL1/P2RY8/NR3C1/P2RX4/ADRB2/OGFR/P2RY13/C3AR1/P2RY6/CHRNE/ADRA2B/P2RX1/HTR7/CSH2/GPR35/PTGER2/CALCRL/LPAR2/ADORA2B/ADORA2A/GABBR1/ADORA3/OXTR/P2RY14/NMB/GHRL/LPAR3/UCN2/SSTR2/GIPR/CYSLTR2/TAC4/CHRNA5/PTGIR/GRIK5/F2RL2/ADRA2C/LYNX1/PTGER3/CNR1/GALR2/CRH/GRIN2D/UTS2	-5.90428355129585
Genetic Information Processing	Translation	hsa03010	Ribosome	9/2577	222/9376	0.147500235975207	MRPL18/DAP3/MRPL23/MRPS10/RPS10-NUDT3/RPS26/MRPS30/RPS4Y1/MRPL53	-7.9138101511161
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	17/2577	449/9376	0.137754489129035	RGS2/GNAL/PDE2A/GNB1/GNG7/SLC8A1/ARRB2/PDE1B/ADCY3/CAMK2G/GRK3/CAMK2D/SLC8A2/SLC24A4/CALM1/CNGB1/CNGA4	-11.5271427647356