category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	71/2270	142/9376	2.06519823788546	MID1/CBLB/UBE2E2/UBE2H/WWP2/UBE2G2/SOCS3/KLHL13/UBE2R2/NEDD4L/UBC/UBA6/SMURF1/UBE2G1/SMURF2/CDC27/UBR5/PRKN/FBXW7/CUL1/TRIP12/UBE2Z/UBE2L6/UBE2Q2/UBE4A/HUWE1/UBA2/BIRC3/HERC1/PML/FANCL/NEDD4/MGRN1/FBXW11/CUL4A/ANAPC16/UBE2K/UBE2Q1/ELOC/ANAPC7/FBXW8/UBE2B/UBE2D3/HERC4/UBE3C/UBE2J1/SAE1/UBE2N/ANAPC5/CBL/CUL3/UBA1/RHOBTB1/HERC2/CUL4B/TRAF6/PIAS3/PIAS1/BTRC/ITCH/MDM2/UBE2E1/FZR1/DDB1/TRIM37/ANAPC1/CUL2/UBOX5/DDB2/VHL/BRCA1	7.2287905522642
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	89/2270	205/9376	1.79319651874933	HLA-DRB1/HLA-DRB5/CDKN1A/AKT3/HLA-DPA1/HLA-F/CCND3/PIK3R3/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/RELB/IKBKB/HLA-DRA/CD40/PIK3CB/HLA-A/TAPBP/TAP1/STAT3/HLA-C/HLA-E/TAP2/STAT1/ENTPD1/TNFAIP3/HLA-DQA2/HLA-DQA1/SIN3A/TBK1/GADD45A/JAK1/MYC/RELA/MAP3K14/E2F3/HLA-DOA/NCOR2/IL6/STAT2/IRF3/PSMD11/NFKBIA/NFKBIB/HES1/NEDD4/PSMD14/NFKB2/SNW1/OAS2/PLCG2/ICAM1/RIPK1/HDAC1/MAP2K3/MAPK11/USP7/IRAK4/EIF2AK2/MAPK12/MAPK8/PSMD13/POLK/IFNAR2/SAP30/IFNAR1/OAS3/BCL2/TRAF6/IRF7/PSMC6/TRAF5/OAS1/MDM2/MAP2K4/AKT2/CASP8/CASP9/BCL2L11/CDK2/MAP2K6/PIK3CA/HLA-G/HLA-DQB2/MAP2K7/DDB2/SAP30L/GADD45G	6.48986030247154
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	86/2270	196/9376	1.81231682100153	CDKN1A/AKT3/GNG12/HLA-F/NFATC1/PIK3R3/HLA-B/IKBKB/PTGS2/FGF2/CLEC2B/ZFP36/MAPKAPK2/TCF7L1/PIK3CB/ANGPT2/HLA-A/PPP3CA/VEGFA/HIF1A/STAT3/TCF7L2/HLA-C/HLA-E/GNB5/NFATC2/STAT1/MAP1LC3A/TNFRSF1A/TBK1/JAK1/MYC/PPP3CC/RELA/E2F3/ITPR3/CXCL2/UBC/TICAM1/MAPK3/MAP2K1/BECN1/IL6/STAT2/LEF1/IRF3/NFKBIA/MAP1LC3B/MTOR/PLCG2/ICAM1/PIK3C3/MAPK11/EIF2AK2/MAPK12/MAPK8/PPP3CB/MAPK1/IFNAR2/C3/GNB1/IFNAR1/GSK3B/IRF7/CREBBP/ITPR1/PLCG1/MICA/GNB4/CXCL1/MAP2K4/AKT2/CXCL3/EP300/CASP8/TLR3/JAK2/CASP9/PPP3R1/MAP2K6/MICB/PDGFB/PIK3CA/HLA-G/MAP2K7/RCAN1	6.49558255475503
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	101/2270	250/9376	1.66868017621145	DNM3/TGFBR2/ASAP1/HLA-F/CBLB/LDLR/SMAD3/HLA-B/EEA1/HLA-A/EHD2/ARAP2/EHD4/HLA-C/RAB11FIP5/HLA-E/SPART/ARAP3/HSPA1B/CYTH1/GRK5/ASAP2/CHMP3/EGFR/CHMP4B/VPS37B/ASAP3/ARPC5L/PIP5K1A/ARFGAP3/ARFGEF2/NEDD4L/RAB11FIP3/GBF1/AP2B1/SMURF1/PARD3/SMURF2/PRKCI/RAB11A/ZFYVE9/PIP5K1C/SMAD2/PML/VPS26A/NEDD4/IGF2R/EHD1/HSPA1A/SH3GL1/AGAP3/RAB22A/SNX1/AP2A1/SPG21/RAB10/RAB35/IST1/WIPF2/HGS/CLTB/SNX12/ARFGEF1/TSG101/RUFY2/DNM2/GIT1/CBL/CYTH2/RAB5A/WIPF3/CHMP2B/TRAF6/VPS37C/CHMP4C/RAB7A/PLD2/USP8/ITCH/ACTR3/IQSEC2/CLTCL1/MDM2/RAB5B/ZFYVE27/HSPA6/AGAP9/HSPA8/CYTH3/ARRB1/GRK4/RAB8A/CXCR4/ARFGAP1/ACAP3/HLA-G/ACTR3B/WASHC2A/AGAP4/ACAP1/AGAP1	6.05667382073062
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	92/2270	224/9376	1.69641283826306	HLA-DRB1/HLA-DRB5/TGFBR2/CDKN1A/AKT3/HLA-DPA1/FOSL1/HLA-F/NFATC1/ETS2/CCND3/CREB5/PIK3R3/HLA-DPB1/SMAD3/HLA-B/HLA-DQB1/IL15/HLA-DMA/RELB/IKBKB/HLA-DRA/ZFP36/CD40/PIK3CB/HLA-A/ETS1/PPP3CA/IL1R1/HLA-C/HLA-E/CRTC3/NFATC2/TNFRSF1A/HLA-DQA2/HLA-DQA1/IL15RA/JAK1/STAT5A/MYC/PPP3CC/RELA/MAP3K14/E2F3/KAT2B/ELK4/STAT5B/HLA-DOA/ADCY4/MAPK3/MAP2K1/CDC27/IL6/SMAD2/NFKBIA/NFKB2/ANAPC16/ICAM1/POLB/CREB3L2/ANAPC7/ATR/ATF2/ATF6B/MAPK8/MAP3K3/PPP3CB/MAPK1/ANAPC5/SMAD4/SRF/CREBBP/ATF4/NFYB/KAT2A/MAP2K4/AKT2/ELK1/EP300/TGFB2/ANAPC1/TBPL1/DLG1/MAD1L1/CDK2/PPP3R1/PIK3CA/HLA-G/HLA-DQB2/LCK/ADCY6/TBP	5.96236745031111
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	101/2270	253/9376	1.6488934547544	FOXO1/ACTN1/AKT3/PIK3R3/PLCB4/SEPTIN6/IKBKB/MYL9/DIAPH1/FNBP1L/CAPN2/PIK3CB/PXN/CAPNS1/IL1R1/CALCOCO2/ITGA5/CASP4/DOCK1/PRKCE/CAST/BCAR1/MAP1LC3A/TNFRSF1A/HK1/CYTH1/TBK1/BCL10/EGFR/ARPC5L/RELA/CTTN/ITPR3/SEPTIN9/UBC/MALT1/MAPK3/SQSTM1/BECN1/CGAS/PTK2/CUL1/RRAGC/SEPTIN8/PLCB1/ELMO1/IRF3/NOD1/NFKBIA/NFKBIB/RPS6KB1/RPTOR/PLCE1/FBXW11/MAP1LC3B/CBX3/MTOR/PLCG2/RBCK1/VCL/PIK3C3/UBE2D3/RIPK1/MAPK11/TNIP1/MAPK12/MAPK8/ATG5/MAPK1/UBE2N/ARHGEF2/ROCK1/C3/CYTH2/FOXO3/GSK3A/GSK3B/BCL2/TRAF6/ITPR1/TRAF5/PLCG1/BTRC/FNBP1/WASF1/ACTR3/MDM2/PLCB3/CRK/AKT2/ACTN4/CYTH3/ROCK2/PLCD4/PIK3R4/HK2/PIK3CA/MYL12A/ACTR3B/RNF31/AKT1S1	5.91358416013688
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	85/2270	203/9376	1.72947635684989	VWF/ACTN1/THBS1/EMP1/AKT3/LAMA3/PDGFD/ITGB4/CCND3/FLT1/VEGFC/PIK3R3/TNC/FLNB/SHC1/TNXB/MYL9/LAMB1/ITGA6/DIAPH1/CAPN2/PIK3CB/FLNA/PXN/VEGFA/RAP1B/ZYX/EMP2/ITGA5/ITGB3/DOCK1/MET/BCAR1/PPP1R12B/PARVB/EGFR/ITGA9/PIP5K1A/MAPK3/PPP1R12C/MAP2K1/PTK2/PIP5K1C/ITGA10/PARVA/BIRC3/BRAF/RAPGEF1/LAMA4/ITGA8/PAK3/ITGA2/VCL/THBS3/RELN/FLT4/MAPK8/MAPK1/ROCK1/SOS2/ARHGAP35/GSK3B/BCL2/ITGA1/PDGFA/LAMB2/LAMA5/ITGAV/COL6A3/CRK/AKT2/PPP1CB/ELK1/PGF/ITGA11/ACTN4/THBS2/RAP1A/ERBB2/FYN/ROCK2/PDGFB/PIK3CA/MYL12A/LAMB3	5.93867430513667
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	77/2270	180/9376	1.76689182574645	HLA-DRB1/CD74/HLA-DRB5/AKT3/HLA-DPA1/HLA-F/PIK3R3/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/IKBKB/HLA-DRA/PIK3CB/HLA-A/TAPBP/TAP1/ITGA5/HLA-C/HLA-E/ITGB3/TAP2/STAT1/SRSF4/TNFRSF1A/HLA-DQA2/HLA-DQA1/TBK1/JAK1/SOCS3/SRPK1/RELA/NECTIN2/HLA-DOA/TICAM1/POU2F1/IFIH1/PTPN11/CGAS/IL6/STAT2/IRF3/NFKBIA/BIRC3/PML/EIF2S1/SP100/MTOR/OAS2/ZC3HAV1/IRAK4/EIF2AK2/PILRB/IFNAR2/EIF2B2/C3/IFNAR1/OAS3/BCL2/TRAF6/IRF7/TRAF5/DAXX/OAS1/NXF1/AKT2/PPP1CB/EIF2B3/HCFC1/CASP8/TLR3/JAK2/CASP9/PIK3CA/HLA-G/HLA-DQB2/IFNG	5.87160518271792
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	53/2270	110/9376	1.99010012014417	INSR/SERPINE1/CDKN1A/AKT3/FLT1/PIK3R3/PFKP/TIMP1/NOS3/PIK3CB/ANGPT2/VEGFA/HIF1A/LDHA/STAT3/HK1/EGFR/RELA/PFKFB3/MAPK3/MAP2K1/IL6/IL6R/RPS6KB1/EGLN3/MTOR/CAMK2D/EIF4E/PLCG2/ELOC/TF/MKNK2/EDN1/MAPK1/BCL2/CREBBP/PLCG1/EGLN1/HMOX1/AKT2/PDK1/PFKM/EP300/ERBB2/CUL2/ALDOB/HK2/ENO2/ALDOC/PIK3CA/GAPDH/VHL/IFNG	5.9035775571577
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	69/2270	157/9376	1.81526978871461	FOXO1/SERPINE1/HIPK3/TGFBR2/CDKN1A/AKT3/HLA-F/NFATC1/CCND3/PIK3R3/SMAD3/HLA-B/MAPKAPK2/CAPN2/PIK3CB/HLA-A/MCU/ETS1/PPP3CA/HIPK2/RRAS2/HLA-C/HLA-E/NFATC2/GADD45A/ZFP36L2/MYC/PPP3CC/RELA/E2F3/ITPR3/MAPK3/RAD9A/MAP2K1/SQSTM1/IL6/SMAD2/FBXW11/MTOR/TRAF3IP2/MAP2K3/MAPK11/ATR/MAPK12/PPP3CB/MAPK1/HIPK1/FOXO3/RBL2/MRAS/RBBP4/ITPR1/BTRC/TRPM7/MDM2/AKT2/PPP1CB/HUS1/TGFB2/LIN54/CDK2/PPP3R1/MAP2K6/PIK3CA/HLA-G/MRE11/LIN52/RAD50/GADD45G	5.82230876570975
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	56/2270	119/9376	1.94371598859808	AKT3/CREB5/VEGFC/PIK3R3/VCAM1/IL15/IKBKB/PTGS2/MLKL/SELE/PIK3CB/BCL3/CX3CL1/CFLAR/TNFAIP3/TNFRSF1A/DAB2IP/ADAM17/IRF1/SOCS3/RELA/MAP3K14/CXCL2/FRMD8/MAPK3/MAP2K1/IL6/NFKBIA/BIRC3/ICAM1/CREB3L2/RIPK1/MAP2K3/MAPK11/ATF2/MAPK12/CASP10/ATF6B/EDN1/MAPK8/MAPK1/IL18R1/CASP7/ATF4/TRAF5/ITCH/CXCL1/MAP2K4/AKT2/CXCL3/CASP8/MAP2K6/PIK3CA/MAP2K7/MMP14/PGAM5	5.85552213528852
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	91/2270	227/9376	1.65579770614605	CDKN1A/AKT3/GNG12/HLA-F/NFATC1/CREB5/PIK3R3/HLA-B/PLCB4/IKBKB/PTGS2/PTK2B/PIK3CB/HLA-A/PXN/PPP3CA/TAPBP/TAP1/VEGFA/AKAP13/STAT3/IL1R1/HLA-C/HLA-E/ITGB3/TAP2/CX3CL1/GNB5/NFATC2/BCAR1/TNFRSF1A/TBK1/JAK1/EGFR/MYC/GNAQ/PPP3CC/RELA/E2F3/ITPR3/ADCY4/MAPK3/SP1/MAP2K1/CGAS/PTK2/IL6/IL6R/PLCB1/IRF3/NFKBIA/RPS6KB1/GNAI3/MTOR/GNA11/CREB3L2/RIPK1/MAPK11/ATF2/MAPK12/ATF6B/PTGER3/PPP3CB/MAPK1/ROCK1/GNB1/SOS2/GSK3B/ARHGEF12/ATF4/GNA12/ITPR1/TRAF5/GNB4/MDM2/PLCB3/ITGAV/ARHGEF1/CRK/AKT2/ELK1/CASP8/ROCK2/CASP9/CXCR4/PPP3R1/MAP2K6/PIK3CA/HLA-G/ADCY6/GNAO1	5.65303889108715
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	53/2270	112/9376	1.95456261799874	HLA-DRB1/HLA-DRB5/AKT3/LAMA3/HLA-DPA1/LDLR/HLA-DPB1/HLA-DQB1/HLA-DMA/IKBKB/LAMB1/HLA-DRA/ITGA6/CD40/STAT3/CIITA/STAT1/TNFRSF1A/HLA-DQA2/HLA-DQA1/HSPA1B/JAK1/RELA/HLA-DOA/MAPK3/NFKBIA/NFKBIB/BIRC3/GNAI3/LAMA4/HSPA1A/MAP2K3/MAPK11/IRAK4/MAPK12/MAPK8/MAPK1/BCL2/TRAF6/LAMB2/LAMA5/HSPA6/AKT2/HSPA8/CASP8/TGFB2/JAK2/CASP9/MAP2K6/HLA-DQB2/LAMB3/GNAO1/IFNG	5.74381080337148
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	46/2270	93/9376	2.04299180522003	ACTN1/INSR/TGFBR2/SMAD3/MYL9/PTPRM/TCF7L1/RAP1B/TCF7L2/MET/FGFR1/CTNNA1/EGFR/NECTIN2/SORBS1/NLK/HEG1/SMURF1/PTPN1/MAPK3/PARD3/SMURF2/IQGAP1/RASIP1/LEF1/NECTIN3/SNAI1/WASF3/VCL/FER/MAPK1/PTPRF/SMAD4/ROCK1/YES1/CREBBP/WASF1/EP300/ACTN4/RAP1A/ERBB2/FYN/ROCK2/BAIAP2/SSX2IP/MYL12A	5.71299916336977
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	40/2270	78/9376	2.11815203885688	ITPKC/PLCB4/PIK3C2A/PIK3CB/INPP1/INPP4B/INPP5A/PIP5K1A/SYNJ2/MTMR6/PIP5K1C/PLCB1/MTMR8/PLCE1/INPP5B/PI4KA/PLCG2/PIK3C3/PIP4K2A/IPPK/PI4KB/INPP5K/IP6K1/IMPA1/MTMR3/PI4K2B/IP6K2/OCRL/PLCG1/ITPK1/MTMR1/PLCB3/MTM1/MTMR4/ALDH6A1/PPIP5K1/PLCD4/PIP4K2C/PIK3CA/IMPA2	5.6045320321395
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	51/2270	109/9376	1.932570828113	RORA/HLA-DRB1/HLA-DRB5/TGFBR2/HLA-DPA1/NFATC1/HLA-DPB1/SMAD3/IL4R/HLA-DQB1/HLA-DMA/IKBKB/HLA-DRA/PPP3CA/HIF1A/STAT3/IL1R1/NFATC2/STAT1/HLA-DQA2/HLA-DQA1/JAK1/STAT5A/AHR/PPP3CC/RELA/RARA/STAT5B/HLA-DOA/MAPK3/IL6/IL6R/STAT6/SMAD2/NFKBIA/NFKBIB/MTOR/HSP90AB1/MAPK11/MAPK12/MAPK8/PPP3CB/MAPK1/SMAD4/PLCG1/IL1RAP/JAK2/PPP3R1/HLA-DQB2/LCK/IFNG	5.53492141052943
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	69/2270	163/9376	1.74845004189076	TGFBR2/CDKN1A/AKT3/HSPG2/NFATC1/CREB5/PIK3R3/SMAD3/IKBKB/PTK2B/PIK3CB/STAT3/NFATC2/STAT1/TBK1/JAK1/STAT5A/MYC/RELA/E2F3/STAT5B/TICAM1/YWHAQ/MAPK3/IFIH1/MAP2K1/IL6/STAT6/STAT2/IRF3/EGR3/NFKBIA/BRAF/CREB3L2/MAP2K3/MAPK11/IRAK4/ATF2/MAPK12/CASP10/ATF6B/MAPK8/MAPK1/SMAD4/IFNAR1/SOS2/BCL2/TRAF6/IRF7/CREBBP/ATF4/YWHAZ/MAP2K4/AKT2/ELK1/ARAF/EP300/DDB1/CASP8/TGFB2/TLR3/JAK2/CASP9/CDK2/MAP2K6/PIK3CA/DDX3X/MAP2K7/DDB2	5.44806209511811
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	47/2270	98/9376	1.98090443225748	ITPKC/PIK3R3/PLCB4/PIK3C2A/PIK3CB/INPP1/INPP4B/INPP5A/PIP5K1A/SYNJ2/MTMR6/ITPR3/PIP5K1C/PLCB1/MTMR8/PLCE1/INPP5B/PI4KA/PLCG2/PIK3C3/PIP4K2A/DGKE/IPPK/CDS2/PI4KB/IP6K1/IMPA1/MTMR3/PI4K2B/IP6K2/ITPR1/OCRL/PLCG1/ITPK1/MTMR1/PLCB3/DGKA/MTM1/MTMR4/PPIP5K1/PLCD4/PIP4K2C/PIK3CA/PIP4P1/DGKI/IMPA2/DGKQ	5.51694324082019
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	121/2270	333/9376	1.50083475546031	VWF/FOXO1/THBS1/CDKN1A/AKT3/LAMA3/ITGB4/HLA-F/PPP2R1B/CCND3/CREB5/PIK3R3/TNC/HLA-B/MAGI1/TNXB/IKBKB/LAMB1/PTGS2/FZD6/ITGA6/TCF7L1/PIK3CB/HLA-A/PXN/VEGFA/PKM/TCF7L2/ITGA5/HLA-C/HLA-E/ITGB3/FZD8/STAT1/PPP2R3A/DLG2/TNFRSF1A/TBK1/JAK1/IRF1/MX1/PPP2R5A/EGFR/ITGA9/PPP2R5C/RELA/WNT5B/CSNK1A1/PSEN1/TICAM1/MAPK3/PARD3/PRKCI/MAP2K1/PPP2R5E/PTK2/ITGA10/NFX1/STAT2/BCAP31/IRF3/HES1/PATJ/RPS6KB1/NOTCH1/LAMA4/ITGA8/MTOR/ITGA2/NOTCH4/THBS3/RELN/CREB3L2/HDAC1/EIF2AK2/ATR/ATP6V1E1/PPP2R2D/MAPK1/IFNAR2/AXIN1/CHD4/UBR4/WNT5A/WNT2B/IFNAR1/SOS2/ATP6V1D/RBL2/GSK3B/ITGA1/MX2/CREBBP/LAMB2/LAMA5/ATP6V0A2/MDM2/ITGAV/FZD4/MAML1/PPP2R5B/COL6A3/AKT2/ITGA11/EP300/THBS2/OASL/CASP8/TADA3/WNT9B/TBPL1/TLR3/DLG1/RFNG/DVL1/CDK2/PIK3CA/HLA-G/LAMB3/LLGL2/TBP	5.25952199562122
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	71/2270	173/9376	1.6951338137557	HLA-DRB1/HLA-DRB5/AKT3/HLA-DPA1/CCND3/PIK3R3/HLA-DPB1/HLA-DQB1/HLA-DMA/IKBKB/HLA-DRA/PIK3CB/DNAJB1/IL33/TNFRSF10B/TRIM25/CALCOCO2/TNFRSF10A/NUP98/CIITA/STAT1/TNFRSF1A/HLA-DQA2/HLA-DQA1/TBK1/JAK1/MX1/SOCS3/RELA/HLA-DOA/ADAR/TICAM1/MAPK3/IFIH1/KPNA1/MAP2K1/RAB11A/IL6/NXT1/STAT2/IRF3/NFKBIA/NFKBIB/PML/EIF2S1/OAS2/ICAM1/HNRNPUL1/KPNA6/IRAK4/EIF2AK2/MAPK1/IFNAR2/IFNAR1/OAS3/MX2/IRF7/CREBBP/OAS1/NXF1/RSAD2/AKT2/EP300/CASP8/TLR3/JAK2/CASP9/PIK3CA/HLA-DQB2/BCL2L2-PABPN1/IFNG	5.2157014050616
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	54/2270	122/9376	1.8282082761609	FOXO1/AKT3/ATP1A1/PIK3R3/PFKP/PLCB4/PIK3CB/HIF1A/ITGB3/STAT1/SIN3A/MYC/RCAN2/KAT2B/MAPK3/MAP2K1/PLCB1/ATP2A2/THRB/PLCE1/NOTCH1/MTOR/PLCG2/NOTCH4/HDAC1/MED27/MED13/MAPK1/MED17/MED13L/NCOR1/GSK3B/CREBBP/PLCG1/NCOA3/KAT2A/MDM2/PLCB3/ITGAV/AKT2/PFKM/EP300/MED14/MED24/HDAC3/PLCD4/CASP9/PIK3CA/BMP4/SLC9A1/SLCO1C1/ATP2A3/NCOA1/RCAN1	5.2040408743462
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	69/2270	169/9376	1.68637489247452	AKT3/PIK3R3/DAPK1/PIK3CB/HIF1A/CALCOCO2/RRAS2/GABARAPL1/VMP1/CFLAR/MAP1LC3A/TBK1/OPTN/DAPK3/CAMKK2/UBC/DDIT4/MAPK3/MAP2K1/SQSTM1/ERN1/BECN1/RRAGC/RPS6KB1/RPTOR/RUBCN/EIF2S1/MAP1LC3B/MTOR/VPS39/UVRAG/PRKAA1/ATG4B/RB1CC1/PIK3C3/ATG2B/STX17/PLEKHM1/ATG101/MAPK8/ATG5/AMBRA1/MAPK1/MTMR3/GORASP2/BCL2/TRAF6/MRAS/ITPR1/ULK1/GORASP1/ATG4A/RAB7A/ZFYVE1/EIF2AK4/ATG13/AKT2/WDR41/TP53INP2/MTMR4/PRKAA2/IRS2/PIK3R4/RAB8A/PIK3CA/ATG9A/EPG5/AKT1S1/YKT6	5.08899043542332
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	109/2270	300/9376	1.5007107195301	INSR/TGFBR2/AKT3/PDGFD/GNG12/NFATC1/FLT1/VEGFC/HSPB1/NR4A1/RELB/IKBKB/FGF2/DUSP5/MAPKAPK2/ANGPT2/FLNA/PPP3CA/RPS6KA2/VEGFA/RAP1B/IL1R1/MAP3K13/RRAS2/DUSP16/MET/RPS6KA3/FGFR1/TNFRSF1A/HSPA1B/GADD45A/CACNB2/EGFR/DDIT3/MYC/PPP3CC/RELA/MAP3K14/JUND/NLK/PLA2G4A/ELK4/DUSP6/MAPK3/MAP2K1/PTPN5/DUSP4/DUSP2/BRAF/NFKB2/CACNA1C/HSPA1A/MAP2K3/MAPK11/IRAK4/FLT4/EPHA2/STK3/ATF2/MAPK12/PPP5C/MAPK8IP3/MKNK2/MAPK8/MAX/CACNA2D1/MAP3K3/PPP3CB/MAPK1/PPM1B/ECSIT/FLT3LG/MAP3K4/MAP3K11/SRF/SOS2/PDGFA/TRAF6/MRAS/ATF4/GNA12/DAXX/IL1RAP/HSPA6/CRK/MAP2K4/AKT2/ELK1/ARAF/PGF/HSPA8/NF1/ARRB1/TAOK1/RAP1A/TGFB2/ERBB2/MAP3K10/DUSP10/PTPN7/MAP4K4/PPP3R1/MAP2K6/PDGFB/MAP3K6/MAP2K7/MAPK7/GADD45G/RASGRP1	4.98179942431792
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	40/2270	83/9376	1.99055251844382	SFMBT2/PHC2/JARID2/KDM2A/ASXL1/PCGF2/PHF1/FOXK1/PCGF5/L3MBTL4/CBX3/EZH2/UBE2D3/HDAC1/USP7/YAF2/CBX7/E2F6/MAX/SUZ12/OGT/RING1/RBBP4/CREBBP/RYBP/EZH1/USP45/PCGF3/EPOP/EP300/EED/HCFC1/LCOR/PHC3/L3MBTL1/TEX10/PHC1/ASXL3/FBRSL1/FBRS	5.1230022819601
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	92/2270	248/9376	1.53224385391502	RHOJ/AKT3/TUBB6/AHNAK/IKBKB/MYL9/MLKL/PIK3C2A/TCF7L1/PIK3CB/FLNA/TNFRSF10B/TCF7L2/TNFRSF10A/CASP4/ANXA2/AHNAK2/TNFRSF1A/CYTH1/DYNC2H1/KLC1/ARPC5L/MYC/RELA/NCKAP1/DYNC1I2/TXN/TUBB4B/MAPK3/KPNA1/MAP2K1/MYO6/KPNA4/IL6/DYNC1LI2/ELMO1/LEF1/NOD1/NFKBIA/BIRC3/PLEKHM2/WASF3/VPS39/PAK3/HSP90AB1/PODXL/PIK3C3/RIPK1/DYNC1H1/MAP2K3/MAPK11/PLEKHM1/IRAK4/ACBD3/MAPK12/MAPK8/MAPK1/TUBA1C/DYNC1LI1/DNM2/DYNC2LI1/CYTH2/EXOC4/RAB5A/BCL2/CASP7/TRAF6/RAB7A/DCTN1/ACTR3/RAB5B/MAP2K4/AKT2/CYTH3/FYCO1/ACTR1B/CASP8/DYNC1I1/ROCK2/S100A10/KLC4/TUBB3/MAP2K6/STX10/DYNLRB2/PIK3CA/MYL12A/ACTR3B/GAPDH/MAP2K7/TUBA4A/KLC2	4.80103249082528
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	82/2270	216/9376	1.56802088432044	AKT3/NFATC1/LDLR/PIK3R3/VCAM1/PLCB4/IKBKB/SELE/CD40/NOS3/PIK3CB/PPP3CA/TNFRSF10B/RAP1B/STAT3/TNFRSF10A/NFATC2/HSPA4/TNFRSF1A/HSPA1B/TBK1/DDIT3/SOD2/PPP3CC/RELA/SELP/CXCL2/TICAM1/POU2F1/MAPK3/ERN1/PTK2/IL6/HSPD1/PLCB1/IRF3/NFKBIA/NFE2L2/EIF2S1/HSPA1A/CAMK2D/HSP90AB1/ICAM1/ATF6/ABCG1/MAP2K3/MAPK11/IRAK4/MAPK12/MAPK8/PPP3CB/MAPK1/HSPA2/APOB/GSK3B/BCL2/CASP7/TRAF6/IRF7/ATF4/ITPR1/PLCG1/CXCL1/PLCB3/HSPA6/ARHGEF1/MAP2K4/AKT2/CXCL3/HSPA8/RAP1A/CASP8/APOA1/JAK2/ROCK2/CASP9/CASP6/PPP3R1/MAP2K6/PIK3CA/MIB2/MAP2K7	4.77341735305949
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	63/2270	157/9376	1.65742024186986	WWTR1/SERPINE1/CCN2/TGFBR2/SMAD1/PPP2R1B/CCND3/SMAD3/TEAD4/TEAD1/FZD6/TCF7L1/BMPR2/YWHAG/TCF7L2/BMP6/FZD8/DLG2/CTNNA1/TEAD2/MYC/FRMD6/BMP2/WNT5B/TP53BP2/SAV1/YWHAQ/PARD3/SMAD7/PRKCI/LATS2/CSNK1D/LEF1/SMAD2/PATJ/BIRC3/YAP1/FBXW11/CSNK1E/STK3/PPP2R2D/AXIN1/SMAD4/WNT5A/WNT2B/GSK3B/WTIP/BTRC/GDF7/YWHAZ/FZD4/RASSF1/PPP1CB/LIMD1/DLG4/AMOT/TGFB2/WNT9B/DLG1/DVL1/BMP4/ID2/LLGL2	4.69501469326962
NA	NA	hsa04518	Integrin signaling	62/2270	154/9376	1.66288689284284	VWF/ACTN1/THBS1/AKT3/LAMA3/PDGFD/ITGB4/CCND3/FLT1/VEGFC/PIK3R3/VCAM1/TNC/FLNB/TNXB/NPNT/LIMS1/LAMB1/FBN1/ITGA6/LIMS2/PIK3CB/FLNA/PXN/VEGFA/ITGA5/ITGB3/MET/PARVB/EGFR/ITGA9/PTK2/ITGA10/PARVA/FERMT2/LAMA4/ITGA8/MTOR/ITGA2/ICAM1/VCL/THBS3/RELN/FLT4/C3/GSK3B/ITGA1/PDGFA/LAMB2/LAMA5/ITGAE/ITGAV/COL6A3/AKT2/PGF/ITGA11/ACTN4/THBS2/ERBB2/PDGFB/PIK3CA/LAMB3	4.6878445135025
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	51/2270	122/9376	1.72664114970752	AKT3/CREB5/PIK3R3/PLCB4/SHC1/SOCS2/PIK3CB/GHR/STAT3/STAT1/BCAR1/STAT5A/SOCS3/GNAQ/ITPR3/STAT5B/ADCY4/MAPK3/MAP2K1/PTK2/PLCB1/GNAI3/CACNA1C/MTOR/PLCG2/GNA11/CREB3L2/MAP2K3/MAPK11/ATF2/MAPK12/ATF6B/MAPK8/MAPK1/SOS2/GSK3B/CREBBP/ATF4/ITPR1/PLCG1/PLCB3/CRK/MAP2K4/AKT2/EP300/IRS2/JAK2/MRAP2/MAP2K6/PIK3CA/ADCY6	4.56584455010347
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	85/2270	232/9376	1.51329181224366	ACTN1/GSN/AKT3/SPATA13/PDGFD/GNG12/ITGB4/TIAM1/PIK3R3/MYL9/MYH9/SSH1/FGF2/ITGA6/DIAPH1/MYH11/BDKRB2/PIK3CB/PXN/ITGA5/RRAS2/ITGB3/DOCK1/MSN/ENAH/LIMK2/FGFR1/BCAR1/PPP1R12B/EGFR/ITGA9/ARPC5L/PIP5K1A/NCKAP1/RDX/MAPK3/PPP1R12C/MAP2K1/PTK2/PIP5K1C/ARHGEF7/ITGA10/DIAPH2/IQGAP1/BRAF/ITGA8/PAK3/ITGA2/VCL/RGCC/PIP4K2A/MAPK1/ROCK1/GIT1/SOS2/ARHGAP35/ITGA1/PDGFA/ARHGEF12/MRAS/GNA12/WASF1/ITGAE/ACTR3/ITGAV/ARHGEF1/SSH2/CRK/AKT2/PPP1CB/BDKRB1/ARAF/ITGA11/ACTN4/ROCK2/CFL2/CXCR4/BAIAP2/PIP4K2C/PDGFB/PIK3CA/MYL12A/ACTR3B/SLC9A1/SSH3	4.47431118486275
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	36/2270	77/9376	1.93109445620459	TGFBR2/CDKN1A/AKT3/PIK3R3/SMAD3/RALGDS/IKBKB/PIK3CB/VEGFA/STAT3/STAT1/GADD45A/JAK1/EGFR/RELA/E2F3/RALB/MAPK3/MAP2K1/SMAD2/RPS6KB1/BRAF/MTOR/MAPK8/POLK/MAPK1/SMAD4/PLD2/AKT2/ARAF/TGFB2/ERBB2/CASP9/PIK3CA/DDB2/GADD45G	4.63667808518519
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	36/2270	77/9376	1.93109445620459	BCR/TGFBR2/CDKN1A/AKT3/PIK3R3/SMAD3/SHC1/CTBP2/IKBKB/PIK3CB/GADD45A/STAT5A/MYC/RELA/E2F3/ABL1/STAT5B/MAPK3/MAP2K1/PTPN11/NFKBIA/BRAF/HDAC1/POLK/MAPK1/SMAD4/CBL/SOS2/MDM2/CRK/AKT2/ARAF/TGFB2/PIK3CA/DDB2/GADD45G	4.63667808518519
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	44/2270	101/9376	1.79938064291011	FOXO1/SERPINE1/TGFBR2/AKT3/NFATC1/VEGFC/PIK3R3/VCAM1/SMAD3/PLCB4/SELE/DIAPH1/THBD/NOS3/PIK3CB/VEGFA/STAT3/STAT1/PRKCE/STAT5A/RELA/STAT5B/MAPK3/IL6/PLCB1/SMAD2/PLCE1/PLCG2/ICAM1/MAPK11/MAPK12/EDN1/MAPK8/MAPK1/SMAD4/BCL2/PLCG1/PLCB3/AKT2/TGFB2/JAK2/PLCD4/NOX4/PIK3CA	4.56502668469909
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	20/2270	34/9376	2.4296449857476	RORA/CRY1/PRKAG2/BHLHE40/NPAS2/NFIL3/PER1/RORB/CRY2/PER2/CUL1/CSNK1D/FBXW11/PRKAA1/CSNK1E/PER3/NR1D1/BTRC/NR1D2/PRKAA2	4.71990978410825
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	76/2270	204/9376	1.53877515764015	THBS1/CDKN1A/AKT3/HSPG2/TIAM1/HOXD10/PIK3R3/FGF2/FZD6/PIK3CB/FLNA/PXN/VEGFA/HIF1A/STAT3/ITGA5/RRAS2/ITGB3/FZD8/MET/MSN/FGFR1/PPP1R12B/EGFR/MYC/CTTN/RDX/ITPR3/WNT5B/MAPK3/PPP1R12C/MAP2K1/PTPN11/PTK2/GAB1/IQGAP1/SMAD2/RPS6KB1/PLCE1/SDC4/TIMP3/BRAF/MTOR/ITGA2/CAMK2D/PLCG2/HBEGF/MAPK11/DDX5/MAPK12/MAPK1/EIF4B/ROCK1/CBL/WNT5A/WNT2B/SOS2/ARHGEF12/MRAS/ITPR1/PLCG1/MDM2/ITGAV/FZD4/ARHGEF1/AKT2/PPP1CB/ELK1/ARAF/TGFB2/WNT9B/ERBB2/ROCK2/PIK3CA/SLC9A1/TWIST2	4.3972037386707
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	54/2270	133/9376	1.6770030803882	FOXO1/INSR/TGFBR2/CDKN1A/AKT3/PIK3R3/SMAD3/IKBKB/PRKAG2/PIK3CB/STAT3/GABARAPL1/BCL6/PLK3/GADD45A/FBXO32/EGFR/HOMER1/SOD2/NLK/MAPK3/MAP2K1/IL6/KLF2/BRAF/SGK3/PRKAA1/CSNK1E/SETD7/MAPK11/USP7/S1PR1/MAPK12/MAPK8/MAPK1/SMAD4/SOS2/FOXO3/RBL2/CREBBP/MDM2/AKT2/ARAF/IL7R/EP300/TGFB2/PRKAA2/IRS2/PLK2/BCL2L11/CDK2/PIK3CA/GADD45G/DEPP1	4.44422413898707
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	40/2270	90/9376	1.8357317670093	AKT3/NFATC1/PIK3R3/IKBKB/PIK3CB/PPP3CA/HIF1A/STAT3/NFATC2/STAT1/JAK1/EGFR/PPP3CC/RELA/TICAM1/MAPK3/MAP2K1/PTPN11/CD274/NFKBIA/NFKBIB/RPS6KB1/MTOR/MAP2K3/MAPK11/MAPK12/MAP3K3/PPP3CB/MAPK1/TRAF6/PLCG1/AKT2/BATF3/JAK2/PPP3R1/MAP2K6/PIK3CA/LCK/RASGRP1/IFNG	4.50256292257259
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	33/2270	70/9376	1.94718691000629	CDKN1A/AKT3/PIK3R3/PIK3CB/ETS1/VEGFA/HIF1A/RAP1B/MET/MAPK3/MAP2K1/PTPN11/GAB1/TFE3/EGLN3/BRAF/RAPGEF1/PAK3/ELOC/MAPK1/SOS2/CREBBP/EGLN1/CRK/AKT2/ARAF/EP300/RAP1A/TGFB2/CUL2/PDGFB/PIK3CA/VHL	4.49561538354987
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	29/2270	59/9376	2.0301948779213	CDKN1A/AKT3/PIK3R3/TCF7L1/PIK3CB/TCF7L2/CTNNA1/GADD45A/EGFR/MYC/MAPK3/MAP2K1/MLH1/LEF1/BRAF/POLK/MAPK1/AXIN1/SOS2/FOXO3/GSK3B/AKT2/ELK1/ARAF/ERBB2/CASP9/PIK3CA/DDB2/GADD45G	4.48635162963032
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	30/2270	62/9376	1.99857893988916	TLE1/CTBP2/SPEN/ADAM17/TLE2/KAT2B/PSEN1/NCOR2/HES1/NOTCH1/SNW1/NUMBL/NOTCH4/NUMB/HDAC1/NRARP/DLL1/CREBBP/ITCH/APH1B/KAT2A/MAML1/TLE3/EP300/DTX3/ATXN1/RFNG/DVL1/ATXN1L/TLE6	4.45857519658397
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	55/2270	138/9376	1.64617250845943	AKT3/NFATC1/PIK3R3/IKBKB/PTK2B/PIK3CB/PXN/RPS6KA2/SKAP2/ITGA5/NFATC2/DOCK1/RPS6KA3/BCAR1/ARHGEF28/TBK1/ARPC5L/GNAQ/RELA/PIP5K1A/TICAM1/MAPK3/MAP2K1/PTK2/IL6/PIP5K1C/ARHGEF7/ELMO1/IRF3/NFKBIA/MAP2K3/MAPK11/IRAK4/MAPK12/MAPK8/MAPK1/WIPF2/ROCK1/GSK3B/WIPF3/TRAF6/ARHGEF12/PLCG1/ACTR3/ARHGEF1/CRK/MAP2K4/AKT2/ROCK2/BAIAP2/MAP2K6/PIK3CA/ACTR3B/MAP2K7/LCK	4.32200242669743
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	69/2270	184/9376	1.5488986784141	PIK3R3/ABLIM1/RND1/BOC/MYL9/SSH1/EPHA4/PIK3CB/BMPR2/PPP3CA/EPHB4/SEMA6B/DPYSL2/NFATC2/MET/ENAH/LIMK2/SEMA6A/SEMA4A/PPP3CC/SEMA3F/WNT5B/ABL1/MAPK3/PARD3/PTPN11/PTK2/SRGAP1/EPHB1/PLXNA4/ABLIM2/ABLIM3/GNAI3/SEMA4D/SEMA3A/PAK3/PLXNA2/CAMK2D/PLCG2/EPHA2/TRPC4/NCK1/PPP3CB/MAPK1/ROCK1/WNT5A/RYK/GSK3B/ROBO3/ARHGEF12/SRGAP2/PLCG1/SEMA3D/GDF7/NTN1/SSH2/SEMA4C/FYN/ROCK2/CFL2/CXCR4/PPP3R1/PIK3CA/MYL12A/SEMA4F/PLXNB1/SEMA6C/SSH3/SEMA4B	4.24993271173773
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	36/2270	80/9376	1.85867841409692	AKT3/PDGFD/PIK3R3/SHC1/FGF2/PIK3CB/VEGFA/STAT3/MET/JAK1/EGFR/MAPK3/MAP2K1/IL6/IL6R/GAB1/RPS6KB1/BRAF/MTOR/EIF4E/PLCG2/MAPK1/SOS2/FOXO3/GSK3B/BCL2/PDGFA/PLCG1/AKT2/ARAF/NF1/ERBB2/JAK2/BCL2L11/PDGFB/PIK3CA	4.35926676760871
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	38/2270	86/9376	1.82505890789878	CDKN1A/AKT3/CBLB/PIK3R3/SHC1/ABL2/PIK3CB/EGFR/STAT5A/MYC/ABL1/STAT5B/MAPK3/MAP2K1/PTK2/GAB1/RPS6KB1/BRAF/MTOR/PAK3/CAMK2D/PLCG2/HBEGF/MAPK8/NCK1/MAPK1/CBL/SOS2/GSK3B/PLCG1/CRK/MAP2K4/AKT2/ELK1/ARAF/ERBB2/PIK3CA/MAP2K7	4.34422480901077
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	67/2270	178/9376	1.55469979705984	TLE1/FOSL1/NFATC1/CCND3/SMAD3/PLCB4/CTBP2/FZD6/TCF7L1/PPP3CA/TCF7L2/FZD8/NFATC2/MYC/PPP3CC/TLE2/CELSR1/NLK/WNT5B/CSNK1A1/PSEN1/TBL1X/CUL1/PLCB1/LEF1/FBXW11/LRP5/CAMK2D/CSNK1E/CCDC88C/DKK1/PPARD/ROR2/ANKRD6/MAPK8/PPP3CB/CACYBP/AXIN1/SMAD4/WNT5A/WNT2B/SENP2/RYK/GSK3B/CREBBP/BTRC/PRICKLE2/TBL1XR1/PLCB3/FZD4/TLE3/CCN4/MCC/CHD8/EP300/INVS/PORCN/DAAM1/WNT9B/ROCK2/CCAR2/DVL1/PPP3R1/SOX17/PRICKLE4/PRICKLE3/TLE6	4.22286570961247
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	44/2270	105/9376	1.73083280889448	HIF1A/CALCOCO2/RRAS2/GABARAPL1/MAP1LC3A/TBK1/PINK1/RELA/OPTN/UBC/SMURF1/SP1/SMURF2/SQSTM1/PRKN/BECN1/MON1B/VCP/HUWE1/TFE3/EIF2S1/MAP1LC3B/TBC1D15/BCL2L13/MAPK8/TFEB/AMBRA1/FOXO3/RAB5A/OPA1/MRAS/ATF4/ULK1/MFN2/RAB7A/USP8/RAB5B/RABGEF1/MFN1/TOMM70/CCZ1B/ATG9A/MON1A/PGAM5	4.2563306640726
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	44/2270	105/9376	1.73083280889448	AKT3/NFATC1/CBLB/PIK3R3/RELB/IKBKB/PTGS2/MAPKAPK2/PIK3CB/BCL3/PPP3CA/RRAS2/NFATC2/STAT1/PLK3/BCL10/IRF1/PPP3CC/RELA/MAP3K14/ITPR3/MALT1/MAPK3/PTPN11/IL6/STAT2/EGR3/NFKBIA/NFKB2/PLCG2/MAPK11/MAPK12/MAPK8/PPP3CB/MAPK1/ARHGEF12/MRAS/ITPR1/MDM2/AKT2/CASP8/KSR1/PPP3R1/PIK3CA	4.2563306640726
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	43/2270	103/9376	1.72434027629272	PPP2R1B/PPP2R3A/SMG6/PPP2R5A/PPP2R5C/SMG1/PPP2R5E/DDX39B/NXT1/MSI2/SMG7/RNGTT/RNPS1/CASC3/ACIN1/CSTF3/TARDBP/FUS/DAZAP1/RBM8A/PPP2R2D/PAPOLA/GSPT1/CPSF7/PELO/WDR33/DDX19B/UPF2/SYMPK/ETF1/UPF3B/SMG5/DDX19A/UPF1/PAPOLG/NXF1/PPP2R5B/HBS1L/WDR82/PPP1CB/CPSF3/BCL2L2-PABPN1/PABPC1L	4.1776983835906
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	77/2270	214/9376	1.48617069455309	AKT3/GNG12/HLA-F/NFATC1/PIK3R3/HLA-B/IKBKB/PTK2B/PIK3CB/HLA-A/PXN/PPP3CA/TAPBP/TAP1/HLA-C/HLA-E/TAP2/GNB5/NFATC2/LIMK2/WEE1/TNFRSF1A/TBK1/GNAQ/PPP3CC/RELA/ITPR3/MAPK3/DCAF1/MAP2K1/CGAS/PTK2/CUL1/IRF3/NFKBIA/RPS6KB1/GNAI3/FBXW11/CUL4A/MTOR/PAK3/PLCG2/GNA11/ELOC/RIPK1/MAP2K3/MAPK11/IRAK4/ATR/MAPK12/MAPK8/PPP3CB/MAPK1/GNB1/BCL2/CUL4B/TRAF6/ITPR1/TRAF5/PLCG1/BTRC/GNB4/AP1G2/CRK/AKT2/DDB1/CASP8/CASP9/APOBEC3G/CFL2/CXCR4/PPP3R1/MAP2K6/PIK3CA/HLA-G/MAP2K7/GNAO1	4.06617892445321
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	119/2270	362/9376	1.35778226689707	VWF/INSR/THBS1/CDKN1A/AKT3/LAMA3/PDGFD/GNG12/ITGB4/PPP2R1B/CCND3/CREB5/FLT1/VEGFC/PIK3R3/TNC/OSMR/IL4R/MAGI1/TNXB/NR4A1/IKBKB/LAMB1/IL3RA/FGF2/MCL1/ITGA6/NOS3/PIK3CB/MAGI2/ANGPT2/CSF3/YWHAG/GHR/VEGFA/ITGA5/ITGB3/GNB5/MET/FGFR1/PPP2R3A/JAK1/PPP2R5A/EGFR/ITGA9/MYC/PPP2R5C/RELA/DDIT4/YWHAQ/MAPK3/MAP2K1/PPP2R5E/PTK2/IL6/IL6R/ITGA10/CDC37/PKN3/PHLPP2/RPS6KB1/GYS1/RPTOR/SGK3/LAMA4/ITGA8/MTOR/ITGA2/EIF4E/PRKAA1/HSP90AB1/THBS3/RELN/CREB3L2/FLT4/EPHA2/ATF2/ATF6B/PPP2R2D/MAPK1/IFNAR2/EIF4B/PHLPP1/FLT3LG/GNB1/IFNAR1/SOS2/FOXO3/RBL2/GSK3B/BCL2/ITGA1/PDGFA/THEM4/ATF4/LAMB2/LAMA5/GNB4/MDM2/YWHAZ/ITGAV/PPP2R5B/COL6A3/IL7/AKT2/IL7R/PGF/ITGA11/THBS2/PRKAA2/ERBB2/JAK2/CASP9/BCL2L11/CDK2/PDGFB/PIK3CA/LAMB3/BRCA1	3.92374057064888
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	31/2270	68/9376	1.88297486395439	AKT3/ZBTB16/PIK3R3/IKBKB/TCF7L1/PIK3CB/STAT3/TCF7L2/STAT5A/MYC/RELA/RARA/RUNX1T1/PER2/DUSP6/STAT5B/MAPK3/MAP2K1/LEF1/RPS6KB1/PML/BRAF/MTOR/PPARD/JUP/MAPK1/SOS2/AKT2/ARAF/PIK3CA/PIM2	4.13010007253471
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	63/2270	170/9376	1.53067634102099	TGFBR2/CDKN1A/AKT3/PIK3R3/SMAD3/SHC1/FZD6/TCF7L1/PIK3CB/TCF7L2/FZD8/MET/GADD45A/EGFR/MYC/E2F3/TXNRD1/WNT5B/CSNK1A1/MAPK3/MAP2K1/GAB1/LEF1/SMAD2/NFE2L2/RPS6KB1/BRAF/SMARCC1/SMARCA2/MTOR/SMARCA4/LRP5/PLCG2/SMARCC2/ARID1B/POLK/MAPK1/AXIN1/SMAD4/WNT5A/WNT2B/SOS2/GSK3B/PLCG1/GSTM3/MGST1/FZD4/HMOX1/AKT2/ELK1/ARAF/ARID2/TGFB2/WNT9B/GSTT2B/DVL1/PHF10/PIK3CA/GSTO2/TXNRD3/DDB2/GADD45G/NQO1	3.9464323879251
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	39/2270	93/9376	1.73210174790394	HLA-DRB1/HLA-DRB5/HLA-DPA1/NFATC1/HLA-DPB1/IL4R/HLA-DQB1/HLA-DMA/IKBKB/HLA-DRA/PPP3CA/NFATC2/STAT1/HLA-DQA2/HLA-DQA1/JAK1/STAT5A/PPP3CC/RELA/STAT5B/HLA-DOA/MAPK3/STAT6/NFKBIA/NFKBIB/NOTCH1/MAPK11/DLL1/MAPK12/MAPK8/PPP3CB/MAPK1/PLCG1/MAML1/JAK2/PPP3R1/HLA-DQB2/LCK/IFNG	4.010095431569
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	37/2270	87/9376	1.75660539774166	TGFBR2/CDKN1A/AKT3/PIK3R3/SMAD3/RALGDS/TCF7L1/PIK3CB/TCF7L2/GADD45A/EGFR/MYC/RALB/MAPK3/MAP2K1/MLH1/LEF1/SMAD2/RPS6KB1/BRAF/MTOR/MAPK8/POLK/MAPK1/AXIN1/SMAD4/SOS2/GSK3B/BCL2/AKT2/ARAF/TGFB2/CASP9/BCL2L11/PIK3CA/DDB2/GADD45G	4.00710336488444
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	44/2270	109/9376	1.66731600856808	FOXO1/INSR/AKT3/CREB5/PIK3R3/ACACB/IKBKB/PRKAG2/NOS3/PIK3CB/RPS6KA2/STAT3/RPS6KA3/PRKCE/PPP1R3B/TNFRSF1A/CPT1A/SOCS3/RELA/PTPN1/PTPN11/IL6/SLC27A4/NR1H2/NFKBIA/RPS6KB1/GYS1/MTOR/PRKAA1/CREB3L2/PYGB/MAPK8/PTPRF/OGT/GSK3B/AKT2/PPP1CB/PPP1R3E/GFPT2/PRKAA2/IRS2/PPP1R3C/PIK3CA/SLC27A3	3.96060176028255
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	53/2270	138/9376	1.58631168996999	FOXO1/INSR/AKT3/CBLB/PIK3R3/ACACB/SHC1/IKBKB/PRKAG2/SOCS2/PIK3CB/PRKAR1B/PPP1R3B/HK1/INPP5A/SOCS3/SORBS1/PTPN1/FLOT1/MAPK3/PRKCI/MAP2K1/RPS6KB1/GYS1/RPTOR/BRAF/RAPGEF1/MTOR/EIF4E/PRKAA1/SOCS4/PYGB/MKNK2/MAPK8/MAPK1/PTPRF/CBL/SOS2/GSK3B/PRKAR2A/ACACA/CRK/AKT2/PPP1CB/ELK1/TRIP10/ARAF/PPP1R3E/PRKAA2/IRS2/PPP1R3C/HK2/PIK3CA	3.92161615308104
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	43/2270	106/9376	1.67553819300141	PLAT/FOXO1/AR/CDKN1A/AKT3/PDGFD/CREB5/PIK3R3/ERG/IKBKB/TCF7L1/PIK3CB/TCF7L2/FGFR1/ZEB1/EGFR/RELA/E2F3/MAPK3/MAP2K1/LEF1/NFKBIA/BRAF/MTOR/HSP90AB1/CREB3L2/MAPK1/SOS2/GSK3B/BCL2/PDGFA/CREBBP/ATF4/MDM2/NKX3-1/AKT2/ARAF/EP300/ERBB2/CASP9/CDK2/PDGFB/PIK3CA	3.95320138277065
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	24/2270	49/9376	2.02305133507147	GALNT18/GALNT10/GALNT15/GALNT1/POGLUT1/GALNT2/GALNT11/ST6GAL1/GALNT7/EOGT/POFUT2/OGT/PLOD3/FUT10/ST3GAL3/FUT11/B3GLCT/B4GALT2/POMT1/RFNG/GALNT17/GXYLT1/GALNT9/B4GALT1	4.05798505553273
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	18/2270	33/9376	2.25294353223869	VAMP5/STX8/SNAP23/STX5/VAMP2/STX6/STX11/GOSR2/VAMP3/STX17/STX4/VTI1A/STX18/STX2/GOSR1/STX1A/VAMP1/YKT6	4.07503421326651
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	31/2270	70/9376	1.82917558212712	HLA-DRB1/CD55/HLA-DRB5/HLA-DPA1/HLA-F/SNTB2/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/ABL2/HLA-DRA/CD40/HLA-A/HLA-C/HLA-E/EIF4G1/HLA-DQA2/HLA-DQA1/SGCD/ABL1/HLA-DOA/NOS1/ICAM1/CASP8/DMD/FYN/CASP9/HLA-G/HLA-DQB2/EIF4G3	3.93550044167085
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	63/2270	174/9376	1.49548837915844	CRYAB/CAPN2/DNAJB1/HSPH1/NPLOC4/SEC24D/PPP1R15A/HSPA1B/UBE2G2/DDIT3/RNF185/ATXN3/UBQLN1/SVIP/UBE2G1/DNAJC5G/DNAJA1/PRKN/ERN1/CUL1/BCAP31/VCP/NFE2L2/HSPA4L/SEC24B/EIF2S1/OS9/DNAJC1/HSPA1A/UBXN4/HSP90AB1/RAD23B/ATF6/UGGT2/SEC24A/UBE2D3/DERL1/STT3B/ATF6B/MAPK8/DAD1/UBE2J1/SEC63/RRBP1/SEC24C/GANAB/NGLY1/SEC23A/BCL2/ATF4/WFS1/SEC31A/UGGT1/HSPA6/HYOU1/SEC62/HSPA8/MBTPS1/SEL1L/HSPBP1/MAP2K7/UBXN2A/SEC31B	3.72866141163581
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	27/2270	60/9376	1.85867841409692	AKT3/PIK3R3/HSPB1/PTGS2/MAPKAPK2/NOS3/PIK3CB/PXN/PPP3CA/VEGFA/SPHK1/NFATC2/PPP3CC/PLA2G4A/MAPK3/MAP2K1/PTK2/PLCG2/MAPK11/MAPK12/PPP3CB/MAPK1/PLCG1/AKT2/CASP9/PPP3R1/PIK3CA	3.77118116391995
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	28/2270	63/9376	1.8357317670093	AASS/KMT2E/KMT2A/ALDH2/EHMT1/EZH2/PLOD2/SETD7/DLST/KMT2C/PHYKPL/DOT1L/PLOD3/HADHA/EZH1/CAMKMT/KMT5B/SETD2/ASH1L/NSD2/SMYD3/ALDH3A2/SETD1A/HYKK/DHTKD1/KMT2B/EHHADH/SETDB2	3.76164969202868
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	57/2270	156/9376	1.50918332768553	CDKN1A/AKT3/PPP2R1B/LDLR/PIK3R3/IKBKB/PIK3CB/YWHAG/STAT3/STAT1/CFLAR/TNFRSF1A/TBK1/JAK1/MX1/EGFR/SOCS3/MYC/RELA/E2F3/TICAM1/YWHAQ/MAPK3/MAP2K1/STAT2/IRF3/NFKBIA/EIF2S1/BRAF/OAS2/RIPK1/EIF2AK2/PPP2R2D/MAPK1/IFNAR2/IFNAR1/SOS2/OAS3/GSK3B/MX2/TRAF6/IRF7/PIAS1/OAS1/YWHAZ/PSME3/RSAD2/AKT2/ARAF/CASP8/TLR3/CASP9/CDK2/PIK3CA/CLDN15/CLDN14/IFNG	3.62457406723058
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	43/2270	110/9376	1.61460953143773	THBS1/TGFBR2/SMAD1/PPP2R1B/SMAD3/FBN1/BMPR2/INHBB/LRRC32/BMP6/SKI/NBL1/SIN3A/MYC/BMP2/SMURF1/MAPK3/SP1/SMAD7/SMURF2/ACVR1B/ZFYVE9/CUL1/SMAD2/RPS6KB1/SKIL/HDAC1/TF/MAPK1/SMAD4/ROCK1/LEMD3/NCOR1/ID3/CREBBP/TGIF1/GDF7/EP300/INHBA/TGFB2/BMP4/ID2/IFNG	3.66467487720597
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	46/2270	120/9376	1.58331864904552	AKT3/PIK3R3/SHC1/IKBKB/MAPKAPK2/PIK3CB/RPS6KA2/RAP1B/IRAK2/RPS6KA3/RELA/ABL1/PSEN1/MAPK3/MAP2K1/PTPN11/IRAK3/GAB1/NFKBIA/NFKBIB/BRAF/RAPGEF1/CAMK2D/PLCG2/MAPK11/IRAK4/ZNF274/MAPK12/MAPK8/MAP3K3/PRDM4/MAPK1/SOS2/FOXO3/GSK3B/BCL2/TRAF6/SH2B1/ATF4/PLCG1/CRK/AKT2/RAP1A/PIK3CA/MAP2K7/MAPK7	3.63471845914686
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	34/2270	82/9376	1.71260341678307	HLA-DRB1/CD74/HLA-DRB5/HLA-DPA1/HLA-F/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DRA/HLA-A/TAPBP/TAP1/HLA-C/HLA-E/TAP2/CIITA/HSPA4/HLA-DQA2/HLA-DQA1/HSPA1B/HLA-DOA/HSPA1A/HSP90AB1/HSPA2/NFYB/HSPA6/PSME3/HSPA8/KLRD1/HLA-G/HLA-DQB2/RFX5/IFNG	3.66302141531475
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	71/2270	205/9376	1.43052755990115	ACTN1/GSN/CDKN1A/HLA-F/CCND3/CREB5/PIK3R3/HLA-B/MAPKAPK2/PIK3CB/HLA-A/PXN/YWHAG/PKM/STAT3/HLA-C/HLA-E/HDAC4/JAK1/HDAC7/STAT5A/RELA/KAT2B/STAT5B/YWHAQ/MAPK3/IRF3/EGR3/NFKBIA/SP100/NFKB2/SNW1/POLB/CREB3L2/HDAC1/USP7/EIF2AK2/ATF2/ATF6B/MAPK1/CHD4/GTF2H1/UBR4/C3/SRF/RBL2/IRF7/CREBBP/ATF4/TRAF5/SND1/KAT2A/MDM2/YWHAZ/EP300/ACTN4/DDB1/CASP8/TBPL1/HDAC5/HDAC3/HDAC6/DLG1/HDAC10/GTF2A1/MAD1L1/CDK2/PIK3CA/HLA-G/DDX3X/TBP	3.52253653927774
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	39/2270	99/9376	1.62712588439461	AKT3/PDGFD/PIK3R3/SLC22A4/RALGDS/PIK3CB/HIF1A/PLPP3/EGFR/PIP5K1A/PLA2G4A/MAPK3/SP1/MAP2K1/GPCPD1/PIP5K1C/RPS6KB1/PLPP1/WASF3/MTOR/DGKE/CHKA/MAPK8/MAPK1/SOS2/PDGFA/PLCG1/PLD2/WASF1/CHPT1/SLC44A2/AKT2/DGKA/PDGFB/PIK3CA/SLC44A1/DGKI/SLC22A5/DGKQ	3.54531240866896
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	21/2270	44/9376	1.97132559070885	HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-F/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DRA/CPE/HLA-A/HLA-C/HLA-E/HLA-DQA2/HLA-DQA1/HLA-DOA/HSPD1/PTPRN2/HLA-G/HLA-DQB2/IFNG	3.64997398692059
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	40/2270	103/9376	1.60403746631881	SERPINE1/TGFBR2/AKT3/PPP2R1B/PIK3R3/PLCB4/IKBKB/BDKRB2/PIK3CB/CFLAR/GNA14/TNFRSF1A/GNAQ/RELA/TICAM1/MAPK3/IL6/PLCB1/SMAD2/NFKBIA/GNAI3/GNAL/GNA11/MAPK11/IRAK4/MAPK12/MAPK8/PPP2R2D/MAPK1/C3/TRAF6/PLCB3/MAP2K4/AKT2/CASP8/TGFB2/ACE/PIK3CA/GNAO1/IFNG	3.48384099194901
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	65/2270	187/9376	1.43569930975995	GBP2/PLCB4/IKBKB/MCU/GBP1/GABARAPL1/CASP4/STAT1/TNFAIP3/MAP1LC3A/GBP4/TBK1/TP53BP1/JAK1/GBP3/RELA/ITPR3/CXCL2/TXN/TICAM1/MAPK3/IL6/STAT2/PLCB1/IRF3/NOD1/NFKBIA/NFKBIB/BIRC3/ERBIN/MAP1LC3B/OAS2/HSP90AB1/RBCK1/NLRP1/RIPK1/MAPK11/IRAK4/CARD8/MAPK12/MAPK8/ATG5/MAPK1/IFNAR2/IFI16/IFNAR1/OAS3/BCL2/TRAF6/IRF7/ITPR1/TRAF5/MFN2/TXNIP/TRPM7/OAS1/DHX33/CXCL1/PLCB3/AIM2/CXCL3/MFN1/CASP8/PANX1/RNF31	3.40141415460787
Human Diseases	Immune disease	hsa05330	Allograft rejection	19/2270	39/9376	2.01224443691404	HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-F/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DRA/CD40/HLA-A/HLA-C/HLA-E/HLA-DQA2/HLA-DQA1/HLA-DOA/HLA-G/HLA-DQB2/IFNG	3.58013981937599
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	41/2270	108/9376	1.56802088432044	NUP98/IPO11/NUP153/AHCTF1/IPO7/KPNA1/KPNA4/DDX39B/NXT1/TNPO1/RNPS1/CASC3/ACIN1/NUP188/KPNB1/KPNA6/RANGAP1/NUP107/TNPO3/RBM8A/IPO5/POM121/SENP2/DDX19B/RANBP17/UPF2/NUP58/XPO5/UPF3B/NUP88/XPO4/DDX19A/UPF1/NXF1/NUP205/XPO7/NUP155/THOC1/NUP43/XPOT/THOC5	3.35559187407343
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	51/2270	142/9376	1.48345225538252	TGFBR2/AKT3/FOSL1/NFATC1/PIK3R3/RELB/IKBKB/TNFRSF11B/FOSL2/PIK3CB/PPP3CA/IL1R1/ITGB3/NFATC2/STAT1/TNFRSF1A/JAK1/SOCS3/PPP3CC/RELA/MAP3K14/JUND/ITPR3/FOSB/MAPK3/MAP2K1/SQSTM1/STAT2/ATP2A2/NFKBIA/NFKB2/PLCG2/MAPK11/MAPK12/MAPK8/PPP3CB/MAPK1/IFNAR2/IFNAR1/TRAF6/ITPR1/AKT2/TGFB2/FYN/PPP3R1/MAP2K6/PIK3CA/MAP2K7/LCK/ATP2A3/IFNG	3.28086826647166
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	45/2270	122/9376	1.52350689680075	AKT3/NFATC1/PPP2R1B/CBLB/PIK3R3/IKBKB/PIK3CB/PPP3CA/NFATC2/PPP2R3A/BCL10/PPP2R5A/PPP3CC/PPP2R5C/RELA/MAP3K14/MALT1/MAPK3/MAP2K1/PPP2R5E/PTPN11/NFKBIA/NFKBIB/PAK3/MAPK11/MAPK12/MAPK8/PPP2R2D/NCK1/PPP3CB/MAPK1/SOS2/GSK3B/PLCG1/PPP2R5B/AKT2/FYN/DLG1/PPP3R1/PIK3CA/MAP2K7/LCK/ITK/RASGRP1/IFNG	3.289451901618
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	53/2270	149/9376	1.46920143097892	RAPGEF4/INSR/DNM3/AKT3/PDGFD/PIK3R3/PLCB4/RALGDS/SHC1/PTK2B/PIK3CB/SPHK1/RRAS2/CYTH1/AGPAT4/PLPP3/EGFR/PIP5K1A/RALB/PLA2G4A/ADCY4/MAPK3/MAP2K1/PTPN11/PIP5K1C/PLCB1/GAB1/PLPP1/MTOR/PLCG2/DGKE/MAPK1/DNM2/CYTH2/SOS2/PDGFA/MRAS/AVPR2/RAPGEF3/GNA12/PLCG1/PLD2/PLCB3/AKT2/DGKA/AGPAT3/CYTH3/FYN/PDGFB/PIK3CA/DGKI/ADCY6/DGKQ	3.26293308164171
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	36/2270	93/9376	1.59886315191133	CDKN1A/AKT3/LAMA3/PIK3R3/IKBKB/LAMB1/PTGS2/ITGA6/PIK3CB/GADD45A/ZBTB17/MYC/RELA/E2F3/PTK2/NFKBIA/BIRC3/LAMA4/ITGA2/MAX/POLK/BCL2/TRAF6/TRAF5/LAMB2/LAMA5/ITGAV/AKT2/CASP9/FHIT/CDK2/PIK3CA/LAMB3/DDB2/GADD45G/TRAF4	3.28027954651152
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	35/2270	90/9376	1.60626529613314	FOXO1/INSR/SESN3/AKT3/CREB5/PIK3R3/PRKAG2/PIK3CB/SOD2/RELA/CAMKK2/ADCY4/ADIPOR2/RPS6KB1/RPTOR/MTOR/EHMT1/EIF4E/PRKAA1/RB1CC1/CREB3L2/ATG101/ATF2/ATF6B/ATG5/FOXO3/ATF4/ULK1/ATG13/AKT2/PRKAA2/IRS2/PIK3CA/ADCY6/AKT1S1	3.26629637805927
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	26/2270	62/9376	1.73210174790394	FOXO1/INSR/AKT3/PIK3R3/CRYAB/PRKAG2/PIK3CB/HSPA1B/SOD2/ADCY4/RPS6KB1/RPTOR/HSPA1A/MTOR/PRKAA1/HDAC1/ATG5/FOXO3/HSPA6/AKT2/HSPA8/PRKAA2/IRS2/PIK3CA/ADCY6/AKT1S1	3.2687758215115
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	31/2270	78/9376	1.64156783011409	DNM3/PIK3R3/SEPTIN6/SHC1/PIK3CB/PXN/ITGA5/DOCK1/MET/BCAR1/CTNNA1/ARPC5L/CTTN/SEPTIN9/PTK2/SEPTIN8/ELMO1/GAB1/ARHGAP10/VCL/CLTB/DNM2/CBL/MAD2L2/CD2AP/WASF1/ACTR3/CLTCL1/CRK/PIK3CA/ACTR3B	3.21574108860955
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	55/2270	158/9376	1.43779624156583	GRB10/INSR/AKT3/PIK3R3/CLIP1/IKBKB/FNIP2/FZD6/PIK3CB/RPS6KA2/FZD8/RPS6KA3/LPIN1/TNFRSF1A/PRR5L/WNT5B/SLC3A2/DDIT4/MAPK3/MAP2K1/RRAGC/RPS6KB1/RPTOR/BRAF/RNF152/FNIP1/MTOR/LRP5/EIF4E/PRKAA1/STRADA/ATP6V1E1/LPIN2/MAPKAP1/MAPK1/EIF4B/WNT5A/WNT2B/SOS2/ATP6V1D/GSK3B/WDR59/ULK1/FZD4/AKT2/CAB39/RICTOR/CAB39L/WNT9B/PRKAA2/SLC7A5/DVL1/PIK3CA/TTI1/AKT1S1	3.13666534475157
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	52/2270	148/9376	1.45122038337897	CDKN1A/AKT3/PIK3R3/SHC1/FGF2/FZD6/TCF7L1/PIK3CB/TCF7L2/FZD8/FGFR1/GADD45A/EGFR/MYC/E2F3/WNT5B/CSNK1A1/MAPK3/SP1/MAP2K1/LEF1/HES1/RPS6KB1/BRAF/NOTCH1/NFKB2/MTOR/LRP5/NOTCH4/FLT4/DLL1/POLK/MAPK1/AXIN1/WNT5A/WNT2B/SOS2/GSK3B/PGR/NCOA3/FZD4/AKT2/ARAF/ESR2/WNT9B/ERBB2/DVL1/PIK3CA/DDB2/GADD45G/NCOA1/BRCA1	3.12717179345574
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	67/2270	200/9376	1.38368281938326	MYO5C/TUBB6/MYO1D/MYO1E/IKBKB/MYH9/MYH11/TNFRSF10B/IL1R1/BAIAP2L1/TNFRSF10A/CASP4/SEC24D/TNFRSF1A/CYTH1/ARPC5L/RELA/CTTN/NCKAP1/MYO5A/ABL1/TUBB4B/MYO1C/MAPK3/MYO6/PTPN11/IL6/NFKBIA/NFKBIB/SEC24B/WASF3/PAK3/SEC24A/RIPK1/MAPK11/IRAK4/MAPK12/MAPK8/NCK1/MAPK1/WIPF2/TUBA1C/SEC24C/ARHGEF2/ROCK1/CYTH2/ABCF2/WIPF3/CASP7/TRAF6/ARHGEF12/GNA12/WASF1/ACTR3/ARHGEF1/CYTH3/CASP8/FYN/ROCK2/CASP9/BAIAP2/TUBB3/ACTR3B/GAPDH/CLDN15/TUBA4A/CLDN14	3.09989235698015
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	45/2270	125/9376	1.48694273127753	AKT3/PPP2R1B/PIK3R3/PLCB4/SGMS2/NOS3/BDKRB2/PIK3CB/SPHK1/PRKCE/PPP2R3A/TNFRSF1A/CERS6/ACER2/PPP2R5A/GNAQ/PPP2R5C/RELA/MAPK3/MAP2K1/PPP2R5E/PLCB1/CERS5/GNAI3/SPTLC1/MAPK11/S1PR1/MAPK12/MAPK8/PPP2R2D/MAPK1/ROCK1/BCL2/GNA12/PLD2/ABCC1/SGMS1/PLCB3/PPP2R5B/AKT2/FYN/ROCK2/PIK3CA/SPTLC3/CERS4	3.09759417281548
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	44/2270	122/9376	1.48965118798296	FOXO1/INSR/AKT3/PPP2R1B/CREB5/LEPR/PIK3R3/PFKP/ACACB/PRKAG2/PIK3CB/PPP2R3A/CPT1A/PPP2R5A/PPP2R5C/CAMKK2/PFKFB3/PPP2R5E/ADIPOR2/RPS6KB1/GYS1/RPTOR/TBC1D1/MTOR/PRKAA1/CREB3L2/STRADA/ELAVL1/RAB10/PPP2R2D/FOXO3/ULK1/PPP2R5B/ACACA/AKT2/PFKM/CAB39/CAB39L/PRKAA2/IRS2/HMGCR/RAB8A/PIK3CA/AKT1S1	3.07671979353709
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	20/2270	45/9376	1.8357317670093	HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-F/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DRA/HLA-A/HLA-C/HLA-E/HLA-DQA2/HLA-DQA1/HLA-DOA/IL6/KLRD1/HLA-G/HLA-DQB2/IFNG	3.17610636287162
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	29/2270	73/9376	1.64084243558023	CDKN1A/AKT3/PIK3R3/PIK3CB/STAT3/MET/GADD45A/EGFR/STAT5A/E2F3/STAT5B/MAPK3/MAP2K1/BRAF/PLCG2/POLK/MAPK1/SOS2/FOXO3/PLCG1/RASSF1/AKT2/ARAF/ERBB2/CASP9/FHIT/PIK3CA/DDB2/GADD45G	3.10661294174902
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	61/2270	181/9376	1.3920120719449	HLA-DRB1/CD74/HLA-DRB5/AKT3/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DRA/EEA1/PPP3CA/SPHK1/IRAK2/CIITA/PLA2R1/STAT1/PLK3/TNFRSF1A/HLA-DQA2/HLA-DQA1/BCL10/JAK1/PPP3CC/RELA/HSPA9/MALT1/HLA-DOA/MAPK3/IL6/HSPD1/CAMK2D/PIK3C3/MAPK11/IRAK4/MAPK12/CASP10/MAPK8/PPP3CB/MAPK1/CEBPG/C3/RAB5A/BCL2/TRAF6/ARHGEF12/CREBBP/NFYB/RAB7A/ATP6V0A2/RAB5B/AKT2/EP300/CASP8/TGFB2/KSR1/JAK2/CASP9/PPP3R1/HLA-DQB2/RFX5/IFNG	3.00987754615346
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	52/2270	150/9376	1.43187077826725	ABCB1/TGFBR2/CDKN1A/AKT3/PIK3R3/SMAD3/SHC1/FGF2/FZD6/TCF7L1/PIK3CB/TCF7L2/FZD8/MET/CTNNA1/GADD45A/EGFR/MYC/E2F3/WNT5B/CSNK1A1/MAPK3/MAP2K1/MLH1/GAB1/LEF1/SMAD2/RPS6KB1/BRAF/MTOR/LRP5/POLK/JUP/MAPK1/AXIN1/SMAD4/WNT5A/WNT2B/SOS2/GSK3B/BCL2/FZD4/AKT2/ARAF/TGFB2/WNT9B/ERBB2/DVL1/CDK2/PIK3CA/DDB2/GADD45G	3.01355199401792
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	54/2270	157/9376	1.42064592160274	THBS1/ATP11C/NFATC1/MFGE8/ATP11B/PBX1/PTGS2/DUSP5/MAPKAPK2/HIF1A/XKR6/TMEM30A/SPHK1/ITGB3/CX3CL1/NFATC2/DOCK1/DUSP16/BCAR1/CPT1A/ATP11A/ADAM17/GULP1/ANO5/MAPK3/ANO6/MAP2K1/PTPN11/PTK2/NR1H2/ELMO1/ATP2A2/DUSP4/DUSP2/VPS39/CAMK2D/SCARF1/MAPK11/PPARD/PROS1/S1PR1/MAPK12/MAPK1/RAB5A/CASP7/RAB7A/RAB5B/ITGAV/CRK/JAK2/SLC16A1/ODC1/PANX1/ATP2A3	3.00407358460944
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	49/2270	140/9376	1.44563876651982	RYR3/PLAT/SERPINE1/CCN2/AKT3/GNG12/SMAD3/PLCB4/PRKAG2/NOS3/SPHK1/RRAS2/GNB5/HDAC4/PRKCE/ACTA2/MAP1LC3A/GNAQ/ITPR3/ADCY4/MAPK3/MAP2K1/BECN1/NOS1/PLCB1/SMAD2/RPS6KB1/GNAI3/KLF2/MAP1LC3B/MTOR/PRKAA1/MEF2D/PIK3C3/MAPK1/SMAD4/GNB1/MRAS/ITPR1/NRF1/GNB4/PLCB3/AKT2/MEF2B/PRKAA2/HDAC5/PIK3R4/SLC9A1/ADCY6	3.00255508972193
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	48/2270	137/9376	1.44714621048908	LMNA/AKT3/PIK3R3/IKBKB/IL3RA/MCL1/CAPN2/PIK3CB/TNFRSF10B/TNFRSF10A/CFLAR/TNFRSF1A/GADD45A/DAB2IP/DDIT3/RELA/MAP3K14/ITPR3/PARP4/MAPK3/MAP2K1/ERN1/PTPN13/CTSF/NFKBIA/BIRC3/EIF2S1/RIPK1/CASP10/MAPK8/MAPK1/TUBA1C/CTSO/BCL2/CASP7/ATF4/ITPR1/DAXX/AKT2/CASP8/CASP9/CASP6/CASP2/BCL2L11/PIK3CA/AIFM1/TUBA4A/GADD45G	2.97977395439453
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	28/2270	71/9376	1.62888875100825	AKT3/PIK3R3/SHC1/SOCS2/PIK3CB/STAT3/SOCS5/STAT1/IRF1/STAT5A/SOCS3/RELA/STAT5B/MAPK3/MAP2K1/SOCS4/MAPK11/MAPK12/MAPK8/MAPK1/SOS2/FOXO3/GSK3B/SOCS6/AKT2/ESR2/JAK2/PIK3CA	3.00628934338522
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	75/2270	233/9376	1.32952676258721	PDLIM1/THBS1/LMNA/ACTG2/HSPG2/DES/ATP1A1/PDLIM3/ITGB4/SYNE2/SNTB2/CSRP1/MYL9/MYH9/SPTBN1/FBN1/SYNE1/ITGA6/DIAPH1/MYH11/PLEC/PDLIM4/FLNC/ZYX/ITGA5/ITGB3/TMOD3/SUN2/TMEM43/ITGA9/FBLN2/SGCD/PDLIM2/TPM4/ITGA10/TMOD1/DIAPH2/LMOD1/TPM2/SUN1/PDLIM7/SDC4/SYNPO2/AGRN/ITGA8/ITGA2/VCL/THBS3/PDLIM5/TMOD2/JUP/TPM3/DSP/CAPN3/TRIM54/ITGA1/COL27A1/SYNE3/ITGAV/COL6A3/INF2/ANKRD1/ITGA11/THBS2/MYOM3/DAAM1/DMD/OBSCN/ENO2/FHL3/TPM1/BGN/FMNL3/LDB3/SPTBN5	2.87879180375211
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	66/2270	201/9376	1.35624958905911	PLAT/FOXO1/TGFBR2/CDKN1A/SMAD1/ZBTB16/PBX1/FLT1/ERG/JMJD1C/CD40/MLF1/TSPAN7/ETV6/ETV1/BCL6/MET/FLI1/AFF1/SIN3A/GADD45A/ZEB1/CDK14/DDIT3/ZBTB17/MYC/RELA/TAF15/RARA/RUNX1T1/KMT2A/PBX3/PER2/ELK4/DUSP6/SP1/PTK2/IL6/TFE3/BIRC3/PML/EWSR1/HDAC1/FUS/DDX5/MAX/POLK/CCNT2/JUP/DOT1L/CCNT1/NCOR1/PDGFA/KDM6A/MDM2/SUPT3H/CDK9/NSD2/ATF1/ASPSCR1/WT1/SS18L1/ID2/DDB2/GADD45G/FUT8	2.88559468591069
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	49/2270	142/9376	1.42527765713222	PLAT/AKT3/ASS1/PIK3R3/VCAM1/IKBKB/SELE/THBD/NOS3/PIK3CB/BMPR2/VEGFA/IL1R1/ITGB3/TNFRSF1A/RELA/TXN/SQSTM1/PTK2/NFE2L2/SDC4/KLF2/PRKAA1/HSP90AB1/ICAM1/MAPK11/MAPK12/EDN1/MAPK8/ARHGEF2/BCL2/PDGFA/GSTM3/MGST1/ITGAV/HMOX1/MAP2K4/AKT2/PRKAA2/GSTT2B/MAP2K6/PDGFB/PIK3CA/BMP4/MAP2K7/GSTO2/MAPK7/NQO1/IFNG	2.88607603789241
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	23/2270	56/9376	1.69641283826306	BOC/HHAT/CSNK1A1/SMURF1/MOSMO/SMURF2/CUL1/CSNK1D/MGRN1/FBXW11/CSNK1G1/CSNK1E/SPOP/CUL3/GSK3B/BCL2/CSNK1G3/BTRC/SPOPL/ARRB1/GPR161/IQCE/EVC2	2.95419249987838
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	23/2270	56/9376	1.69641283826306	HSF1/HSPA1B/RELA/CXCL2/IL6/CLK1/HSPD1/VCP/NFKBIA/NFKB2/HSPA1A/BCL2L13/C3/CASP7/RAB1B/CXCL1/HSPA6/HBS1L/CXCL3/HSPA8/CLK4/CASP8/CASP9	2.95419249987838
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	14/2270	29/9376	1.99398450554458	WWTR1/TEAD4/TEAD1/TEAD2/FAT4/FRMD6/SAV1/LATS2/YAP1/CSNK1E/STK3/WTIP/RASSF1/LIMD1	3.02990113215807
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	25/2270	63/9376	1.63904622054402	POLE4/POLR2J3/POLR2H/CCNH/POLR2B/XPC/CUL4A/RAD23B/POLR2A/RFC1/ERCC6/GTF2H1/ERCC1/CDK7/CUL4B/CETN2/MNAT1/RPA1/RFC2/DDB1/UVSSA/POLD3/POLR2D/DDB2/ERCC4	2.8763631030849
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	63/2270	193/9376	1.34826413457807	CCL14/AKT3/GNG12/CCL21/TIAM1/PIK3R3/PLCB4/SHC1/IKBKB/PTK2B/PIK3CB/PXN/RAP1B/STAT3/CX3CL1/GNB5/STAT1/BCAR1/GRK5/CCL23/GNAQ/RELA/CXCL2/STAT5B/ADCY4/MAPK3/PARD3/MAP2K1/PTK2/STAT2/PLCB1/ELMO1/NFKBIA/NFKBIB/GNAI3/BRAF/PLCG2/FGR/MAPK1/ROCK1/GNB1/SOS2/FOXO3/GSK3A/GSK3B/PLCG1/CCL16/GNB4/CXCL1/PLCB3/CRK/AKT2/CXCL3/ARRB1/GRK4/RAP1A/JAK2/ROCK2/CXCR4/CCL15/PIK3CA/ITK/ADCY6	2.7630012360866
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	49/2270	144/9376	1.4054821341165	FOXO1/AKT3/ACACB/IKBKB/PRKAG2/TCF7L1/TCF7L2/LPIN1/TNFRSF1A/CPT1A/TBK1/RELA/MAP3K14/CAMKK2/CXCL2/TICAM1/ALDH2/IL6/ADIPOR2/LEF1/IRF3/NFKBIA/PRKAA1/IL17RA/RIPK1/MAP2K3/MAPK11/IRAK4/MAPK12/MAPK8/LPIN2/C3/FOXO3/GSK3B/TRAF6/TRA2A/CXCL1/ACACA/MAP2K4/AKT2/CXCL3/CASP8/PRKAA2/ALDH3A2/NOX4/MAP2K6/MAP2K7/ACOX3/ACOX1	2.77134782833715
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	52/2270	155/9376	1.38568139832315	THBS1/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-F/TUBB6/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DRA/EEA1/HLA-A/TAP1/ITGA5/HLA-C/HLA-E/ITGB3/TAP2/PLA2R1/HLA-DQA2/HLA-DQA1/DYNC2H1/DYNC1I2/TUBB4B/HLA-DOA/DYNC1LI2/NOS1/STX12/ITGA2/THBS3/VAMP3/PIK3C3/DYNC1H1/ATP6V1E1/HGS/STX18/TUBA1C/DYNC1LI1/C3/ATP6V1D/RAB5A/RAB7A/ATP6V0A2/RAB5B/ITGAV/THBS2/DYNC1I1/TUBB3/HLA-G/HLA-DQB2/TUBA4A	2.73647507242633
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	26/2270	67/9376	1.60284042343349	PLCB4/PPP3CA/RPS6KA2/RAP1B/RPS6KA3/GNAQ/PPP3CC/ITPR3/MAPK3/MAP2K1/PLCB1/BRAF/CACNA1C/CAMK2D/PPP3CB/MAPK1/CREBBP/RAPGEF3/ATF4/ITPR1/PLCB3/PPP1CB/ARAF/EP300/RAP1A/PPP3R1	2.79881515996817
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	75/2270	238/9376	1.30159552807907	INSR/PLA1A/AKT3/PDGFD/GNG12/TIAM1/ETS2/FLT1/VEGFC/PIK3R3/RASAL2/RALGDS/SHC1/IKBKB/ABL2/FGF2/PIK3CB/ANGPT2/ETS1/VEGFA/RAP1B/RRAS2/GNB5/MET/FGFR1/RALGAPA2/TBK1/RASA4/EGFR/RELA/RALGAPA1/RALB/RAPGEF5/PLA2G4A/ABL1/MAPK3/MAP2K1/PTPN11/GAB1/PLCE1/PLA2G12A/SYNGAP1/PAK3/RASA4B/PLCG2/SHOC2/FLT4/EPHA2/MAPK8/MAPK1/RALGAPB/RIN1/FLT3LG/GNB1/SOS2/RASAL3/RAB5A/PDGFA/MRAS/PLCG1/PLD2/GNB4/RAB5B/RASSF1/RGL2/AKT2/ELK1/PGF/NF1/RAP1A/BRAP/KSR1/PDGFB/PIK3CA/RASGRP1	2.66362918417043
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	16/2270	36/9376	1.8357317670093	ST6GALNAC3/B4GALT5/GALNT18/GALNT10/GALNT15/GCNT1/GALNT1/ST3GAL1/GALNT2/GALNT11/GCNT4/GALNT7/ST6GALNAC4/GALNT17/ST6GALNAC2/GALNT9	2.83942687077315
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	40/2270	115/9376	1.43665964374641	CDKN1A/CREB5/PLCB4/PTHLH/AKAP13/FGFR1/EGFR/GNAQ/JUND/WNK1/ITPR3/ADCY4/MAPK3/SP1/MAP2K1/STK39/PLCB1/GNAI3/BRAF/LRP5/GNA11/MEF2D/CREB3L2/HBEGF/ATF2/ATF6B/MAPK1/BCL2/ATF4/GNA12/MMP24/ITPR1/PLD2/PLCB3/ARHGEF1/ARAF/OXSR1/ARRB1/MMP14/ADCY6	2.66286408001653
Human Diseases	Infectious disease: viral	hsa05162	Measles	46/2270	136/9376	1.39704586680487	AKT3/CBLB/CCND3/PIK3R3/IKBKB/PIK3CB/STAT3/STAT1/MSN/TNFAIP3/HSPA1B/TBK1/JAK1/MX1/STAT5A/RELA/STAT5B/ADAR/IFIH1/IL6/STAT2/IRF3/NFKBIA/NFKBIB/EIF2S1/HSPA1A/OAS2/IRAK4/EIF2AK2/MAPK8/IFNAR2/IFNAR1/OAS3/GSK3B/BCL2/MX2/TRAF6/IRF7/OAS1/HSPA6/AKT2/HSPA8/CASP8/CASP9/CDK2/PIK3CA	2.63608926918113
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	29/2270	78/9376	1.53566022817124	HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/PTGS2/HLA-DRA/STAT1/HLA-DQA2/HLA-DQA1/MARCKSL1/JAK1/RELA/HLA-DOA/MAPK3/NFKBIA/NFKBIB/MAPK11/IRAK4/MAPK12/MAPK1/C3/TRAF6/ELK1/TGFB2/JAK2/HLA-DQB2/IFNG	2.68489865671401
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	44/2270	130/9376	1.39798034564554	TGFBR2/AKT3/GNG12/CREB5/VEGFC/PIK3R3/PLCB4/SHC1/NOS3/PIK3CB/RXFP1/VEGFA/GNB5/ACTA2/EGFR/RELA/ADCY4/MAPK3/MAP2K1/NOS1/PLCB1/SMAD2/NFKBIA/GNAI3/CREB3L2/MAPK11/ATF2/MAPK12/ATF6B/EDN1/MAPK8/MAPK1/GNB1/SOS2/ATF4/GNB4/PLCB3/MAP2K4/AKT2/ARRB1/PIK3CA/MAP2K7/ADCY6/GNAO1	2.5825118423169
Cellular Processes	Cell motility	hsa04814	Motor proteins	62/2270	194/9376	1.32002361596803	MYO5C/ACTG2/TUBB6/MYO1D/MYO1E/STARD9/MYL9/MYH9/KIFC3/MYH11/DNAH14/ACTA2/KIF16B/KIF9/DYNC2H1/KLC1/MYO18A/MYO5A/DYNC1I2/TPM4/TUBB4B/KIF13A/MYO1C/MYO6/KIF3C/DYNC1LI2/KIF1C/TPM2/KIF21A/MYO15B/MYO9B/KIF13B/HOOK3/DYNC1H1/MYO19/KIF17/TPM3/TUBA1C/DYNC1LI1/KIF3B/DYNC2LI1/KIF27/DNAH6/MYO9A/KIF2A/DCTN1/KIF22/TUBE1/ACTR1B/DNAL1/DYNC1I1/KLC4/TUBB3/DYNLRB2/MYL12A/TPM1/BICDL1/KIF26A/KIF21B/TUBA4A/DNAH1/KLC2	2.5456589182906
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	16/2270	37/9376	1.78611739492797	UAP1/GMDS/PGM2/HK1/GPI/PMM2/NANS/GNE/PGM1/UGDH/UGP2/GFPT2/CMAS/GNPNAT1/HK2/FPGT	2.70784652518026
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	16/2270	37/9376	1.78611739492797	CDKN1A/TCF7L1/TCF7L2/GADD45A/MYC/MAPK3/MAP2K1/LEF1/BRAF/TFG/CCDC6/POLK/MAPK1/TPM3/DDB2/GADD45G	2.70784652518026
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	51/2270	155/9376	1.35903367912463	CDKN1A/PBX1/CREB5/LDLR/PLCB4/NR4A1/FZD6/TCF7L1/RAP1B/TCF7L2/FZD8/PDE8A/EGFR/GNAQ/AHR/E2F3/ITPR3/KMT2A/WNT5B/ADCY4/MAPK3/SP1/MAP2K1/PLCB1/LEF1/GNAI3/BRAF/CACNA1C/CAMK2D/GNA11/CREB3L2/ATF2/ATF6B/MAPK1/AXIN1/WNT5A/WNT2B/GSK3B/ATF4/ITPR1/USP8/PLCB3/FZD4/RAP1A/WNT9B/DVL1/NCEH1/RASD1/CDK2/ARMC5/ADCY6	2.54740497560337
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	33/2270	93/9376	1.46562455591872	PLCB4/PTK2B/EGFR/GNAQ/ITPR3/PLA2G4A/ADCY4/MAPK3/MAP2K1/PLCB1/CACNA1C/CAMK2D/GNA11/HBEGF/MAP2K3/MAPK11/MAPK12/MAPK8/MAP3K3/MAPK1/MAP3K4/SOS2/ATF4/ITPR1/PLD2/PLCB3/MAP2K4/ELK1/MAP2K6/MAP2K7/MAPK7/MMP14/ADCY6	2.55046366145405
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	36/2270	104/9376	1.4297526262284	PLA1A/SGMS2/MBOAT7/LPIN1/AGPAT4/PLPP3/GPAT3/PLA2G4A/GPCPD1/GPD1L/LPGAT1/PLPP1/PLA2G12A/SELENOI/PISD/DGKE/LPCAT4/CDS2/GPD2/CHKA/PLPP5/LPIN2/PGS1/GPAT4/LPCAT1/PLD2/CHPT1/SGMS1/CRLS1/DGKA/AGPAT3/ADPRM/PNPLA7/DGKI/GDPD5/DGKQ	2.49077479755122
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	17/2270	41/9376	1.71260341678307	THBS1/CDKN1A/DAPK1/VEGFA/EGFR/MYC/E2F3/DAPK3/MAPK3/MAP2K1/BRAF/HBEGF/MAPK1/MDM2/RASSF1/ARAF/ERBB2	2.58445296528561
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	10/2270	20/9376	2.06519823788546	UAP1/GMDS/CYB5R3/NANS/GNE/UGDH/CYB5RL/CYB5R1/UGP2/CMAS	2.69517081890573
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	33/2270	94/9376	1.45003280532384	FOSL1/IKBKB/PTGS2/CSF3/TNFAIP3/TBK1/RELA/JUND/MAPK6/CXCL2/FOSB/MAPK3/IL6/NFKBIA/HSP90AB1/IL17RA/ELAVL1/TRAF3IP2/MAPK11/MAPK12/MAPK8/MAPK1/ANAPC5/GSK3B/TRAF6/TRAF5/CXCL1/CXCL3/USP25/CASP8/MAPK7/IFNG/TRAF4	2.47841074330549
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	34/2270	98/9376	1.43299469567563	GSN/ASAP1/AKT3/PIK3R3/PIK3CB/SPHK1/DOCK1/PRKCE/LIMK2/MARCKSL1/ASAP2/PLPP3/ASAP3/ARPC5L/PIP5K1A/PLA2G4A/MAPK3/MAP2K1/PIP5K1C/RPS6KB1/PLPP1/WASF3/PLCG2/MAPK1/DNM2/PLCG1/PLD2/WASF1/ACTR3/CRK/AKT2/CFL2/PIK3CA/ACTR3B	2.43531080201256
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	36/2270	105/9376	1.41613593455003	CCL21/VCAM1/RELB/IKBKB/PTGS2/CD40/TRIM25/IL1R1/CFLAR/TNFAIP3/TNFRSF1A/BCL10/GADD45A/PPP1R13L/ERC1/RELA/MAP3K14/CXCL2/MALT1/TICAM1/NFKBIA/BIRC3/NFKB2/PLCG2/ICAM1/RIPK1/IRAK4/BCL2/TRAF6/TRAF5/PLCG1/CXCL1/CARD10/CXCL3/LCK/GADD45G	2.42355312609335
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	26/2270	71/9376	1.51253955450766	AKT3/PIK3R3/PFKP/PIK3CB/HIF1A/LDHA/PKM/MET/FGFR1/HK1/EGFR/GLS/MYC/MAPK3/MAP2K1/MTOR/SLC1A5/MAPK1/AKT2/PDK1/PFKM/ERBB2/SCO2/SLC7A5/HK2/PIK3CA	2.45010297657491
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	28/2270	78/9376	1.48270642719982	PFKP/BTG1/HSPA9/TENT4A/HSPD1/XRN2/CNOT9/DDX6/PNPT1/CNOT1/CNOT4/ZCCHC7/DIS3/TENT4B/PATL1/CNOT10/DCP1A/MTREX/TOB2/PFKM/EXOSC10/PAN2/XRN1/ENO2/CNOT6/DCP1B/DCPS/PABPC1L	2.41947744076623
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	34/2270	99/9376	1.41852000177991	CDKN1A/AKT3/PIK3R3/SHC1/PIK3CB/EGFR/E2F3/ADCY4/MAPK3/SP1/MAP2K1/PTK2/RPS6KB1/BRAF/NOTCH1/MTOR/NOTCH4/HBEGF/MAPK11/DLL1/MAPK12/MAPK8/MAPK1/NCOR1/SOS2/BCL2/NCOA3/MDM2/AKT2/ARAF/ESR2/ERBB2/PIK3CA/ADCY6	2.36600687758064
NA	NA	hsa04517	IgSF CAM signaling	89/2270	299/9376	1.22944911820606	FOXO1/ACTN1/TJP2/APP/MAP2/TRIO/EPB41L3/AKT3/TUBB6/PIK3R3/MAGI1/MYL9/MYH9/SPTBN1/MYH11/PIK3CB/MAGI2/PXN/NLGN1/RAP1B/ITGA5/ITGB3/MSN/FGFR1/BCAR1/PVR/CABLES1/ARPC5L/ERC1/NECTIN2/SORBS1/RDX/ABL1/TUBB4B/MAPK3/PARD3/PRKCI/MAP2K1/PTPN11/PTK2/SRGAP1/IQGAP1/PLXNA4/NECTIN3/PAK3/PLXNA2/PLCG2/ICAM1/VCL/ESAM/MAPK11/MPDZ/MAPK12/CADM1/CASK/MAPK8/NCK1/MAPK1/PTPRF/TUBA1C/ROBO4/GIT1/GSK3B/ROBO3/F11R/TRAF6/SRGAP2/PLCG1/CD2AP/IL1RAP/ACTR3/NTN1/AKT2/ACTN4/PPFIA3/RAP1A/FYN/BAIAP2/SSX2IP/TUBB3/PIK3CA/MYL12A/CD2/ACTR3B/TUBA4A/LCK/PPFIA2/NLGN2/SPTBN5	2.2789604307723
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	45/2270	139/9376	1.33717871517764	AKT3/GABBR1/CREB5/PIK3R3/PLCB4/FKBP5/SHC1/NOS3/PIK3CB/HSPA1B/EGFR/GNAQ/RARA/FKBP4/ITPR3/ADCY4/MAPK3/SP1/MAP2K1/PLCB1/GNAI3/HSPA1A/HSP90AB1/CREB3L2/HBEGF/GREB1/ATF2/ATF6B/MAPK1/SOS2/BCL2/EBAG9/ATF4/PGR/ITPR1/NCOA3/PLCB3/HSPA6/AKT2/HSPA8/ESR2/PIK3CA/ADCY6/NCOA1/GNAO1	2.26353933011637
Human Diseases	Cancer: specific types	hsa05214	Glioma	27/2270	76/9376	1.46737769533967	CDKN1A/AKT3/PIK3R3/SHC1/PIK3CB/GADD45A/EGFR/E2F3/MAPK3/MAP2K1/CAMK1D/BRAF/MTOR/CAMK2D/PLCG2/POLK/MAPK1/SOS2/PDGFA/PLCG1/MDM2/AKT2/ARAF/PDGFB/PIK3CA/DDB2/GADD45G	2.31216737960357
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	24/2270	66/9376	1.50196235482579	RORA/HLA-DRB1/HLA-DRB5/HLA-DPA1/NFATC1/HLA-DPB1/SMAD3/IL4R/HLA-DQB1/HLA-DMA/HLA-DRA/STAT3/STAT1/HLA-DQA2/HLA-DQA1/RELA/HLA-DOA/IL6/STAT6/SMAD2/IL18R1/TGFB2/HLA-DQB2/IFNG	2.31288607022165
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	65/2270	212/9376	1.26639514587316	RAPGEF4/INSR/THBS1/DOCK4/AKT3/PDGFD/TIAM1/FLT1/VEGFC/PIK3R3/PLCB4/RALGDS/MAGI1/FGF2/PRKD1/PIK3CB/MAGI2/ANGPT2/PRKD2/VEGFA/RAP1B/ITGB3/MET/ENAH/FGFR1/BCAR1/ARAP3/EGFR/GNAQ/RALB/RAPGEF5/ADCY4/MAPK3/PARD3/PRKCI/MAP2K1/CNR1/PRKD3/PLCB1/PLCE1/GNAI3/BRAF/RAPGEF1/MAP2K3/MAPK11/FLT4/EPHA2/MAPK12/MAPK1/SIPA1L1/PDGFA/MRAS/RAPGEF3/PLCG1/PLCB3/CRK/F2RL3/AKT2/PGF/RAP1A/MAP2K6/PDGFB/PIK3CA/ADCY6/GNAO1	2.21736742193462
Organismal Systems	Immune system	hsa04611	Platelet activation	41/2270	126/9376	1.34401790084609	VWF/AKT3/PIK3R3/PLCB4/NOS3/PIK3CB/RAP1B/ITGB3/STIM1/GNAQ/ITPR3/PLA2G4A/SNAP23/ADCY4/MAPK3/PRKCI/PLCB1/GNAI3/ITGA2/PLCG2/MAPK11/MAPK12/MAPK1/ROCK1/ARHGAP35/ARHGEF12/ITPR1/PLCB3/ARHGEF1/F2RL3/AKT2/PPP1CB/RAP1A/FYN/PRKG1/ROCK2/PIK3CA/MYL12A/GP6/ADCY6/RASGRP1	2.19725981405463
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	46/2270	144/9376	1.31943220753793	SMAD1/AKT3/PIK3R3/SMAD3/FGF2/FZD6/PIK3CB/BMPR2/INHBB/STAT3/FZD8/FGFR1/JARID2/JAK1/MYC/WNT5B/KAT6A/MAPK3/MAP2K1/ACVR1B/SMAD2/PCGF2/SKIL/PCGF5/MAPK11/MAPK12/MAPK1/SMARCAD1/AXIN1/SMAD4/WNT5A/WNT2B/ID3/GSK3B/RIF1/PCGF3/FZD4/AKT2/INHBA/WNT9B/JAK2/DVL1/PIK3CA/BMP4/ID2/HOXD1	2.18322258905459
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	52/2270	166/9376	1.29385913698848	INSR/PDE2A/AKT3/ATP1A1/NFATC1/ATP2B4/CREB5/PLCB4/MYL9/NOS3/BDKRB2/PPP3CA/NFATC2/PRKCE/GNAQ/NPR1/PPP3CC/ITPR3/ATP2B1/ADCY4/MAPK3/MAP2K1/PLCB1/ATP2A2/GNAI3/CACNA1C/GNA11/MEF2D/CREB3L2/ATF2/ATF6B/PPP3CB/MAPK1/ROCK1/SRF/PDE3A/ATF4/GNA12/ITPR1/PLCB3/AKT2/PPP1CB/KCNMA1/MEF2B/KCNMB1/IRS2/PRKG1/ROCK2/PPP3R1/ADRA2C/ATP2A3/ADCY6	2.15898384650234
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	18/2270	47/9376	1.58185396944418	INSR/PIK3R3/IKBKB/SOCS2/PIK3CB/PKM/PRKCE/HK1/SOCS3/MAPK3/CACNA1C/MTOR/SOCS4/MAPK8/MAPK1/IRS2/HK2/PIK3CA	2.26011922292379
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	53/2270	170/9376	1.28771184244623	ACTN1/TJP2/TIAM1/PPP2R1B/YBX3/MAGI1/SYNPO/MYL9/MYH9/PRKAG2/MYH11/RAB8B/PRKCE/MSN/DLG2/HSPA4/RAB13/ARPC5L/ARHGAP17/CTTN/RDX/NEDD4L/PARD3/PRKCI/AMOTL1/PATJ/NEDD4/PRKAA1/MPDZ/MAPK8/PPP2R2D/TUBA1C/ARHGEF2/ROCK1/SYMPK/F11R/MICALL2/ACTR3/ACTN4/RAP1A/AMOT/PRKAA2/ERBB2/DLG1/ROCK2/RAB8A/MYL12A/ACTR3B/MAP2K7/CLDN15/TUBA4A/CLDN14/LLGL2	2.13960044126877
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	17/2270	44/9376	1.5958350020024	TAF4B/TAF15/CCNH/TAF1/TAF2/GTF2H1/CDK7/MNAT1/TAF3/TAF9B/TBPL1/TAF11/GTF2F2/TAF5L/GTF2A1/TAF4/TBP	2.23898379555556
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	17/2270	44/9376	1.5958350020024	CREB5/DYNC2H1/DYNC1I2/RAB11A/DYNC1LI2/VAMP2/CREB3L2/DYNC1H1/STX4/DYNC1LI1/DYNC2LI1/RAB5A/AVPR2/DCTN1/RAB5B/DYNC1I1/ADCY6	2.23898379555556
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	33/2270	99/9376	1.37679882525697	LMNA/DES/ITGB4/SNTB2/PRKAG2/ITGA6/ITGA5/ITGB3/CACNB2/ITGA9/SGCD/TPM4/IL6/ITGA10/NOS1/TPM2/ATP2A2/CACNA1C/ITGA8/ITGA2/PRKAA1/EDN1/CACNA2D1/TPM3/ITGA1/ITGAV/ITGA11/TGFB2/DMD/ACE/PRKAA2/TPM1/ATP2A3	2.13014577136298
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	15/2270	38/9376	1.63041966148852	UAP1/PGM2/HK1/GPI/PMM2/GNE/PGM1/UGDH/UGP2/GFPT2/HEXB/GNPNAT1/GNPDA2/HK2/FPGT	2.20080000400699
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	52/2270	168/9376	1.27845605202433	CDKN1A/AKT3/CCND3/LEPR/PIK3R3/OSMR/IL4R/IL15/IL3RA/MCL1/SOCS2/PIK3CB/CSF3/GHR/STAT3/SOCS5/STAT1/IL15RA/JAK1/EGFR/STAT5A/SOCS3/CLCF1/MYC/STAT5B/PTPN11/IL6/IL6R/STAT6/STAT2/MTOR/SOCS4/TSLP/IFNAR2/IFNAR1/IL13RA1/SOS2/BCL2/PDGFA/CREBBP/PIAS3/PIAS1/SOCS6/IL7/AKT2/IL7R/EP300/JAK2/IL11RA/PDGFB/PIK3CA/IFNG	2.0583281433108
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	30/2270	89/9376	1.39226847497896	VWF/THBS1/HSPG2/LAMA3/ITGB4/TNC/TNXB/NPNT/LAMB1/ITGA6/ITGA5/ITGB3/ITGA9/ITGA10/SDC4/AGRN/LAMA4/ITGA8/ITGA2/THBS3/RELN/ITGA1/LAMB2/LAMA5/ITGAV/COL6A3/ITGA11/THBS2/GP6/LAMB3	2.10148673414137
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	25/2270	72/9376	1.43416544297602	IKBKB/ZNFX1/TRIM25/TBK1/RELA/ADAR/IFIH1/OTUD5/IRF3/NFKBIA/NFKBIB/RIPK1/MAPK11/MAPK12/CASP10/MAPK8/ATG5/TRAF6/IRF7/AZI2/CASP8/TKFC/DDX3X/DHX58/TBKBP1	2.09012671278829
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	20/2270	55/9376	1.50196235482579	B4GALT5/SGMS2/ACER3/SPHK1/UGCG/CERS6/ACER2/PLPP3/KDSR/CERS5/PLPP1/SPTLC1/GBA2/CERK/SGMS1/HEXB/SMPD4/SPTLC3/CERS4/GALC	2.11012024383338
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/2270	32/9376	1.67797356828194	GABARAPL1/BECN1/RPTOR/MTOR/ATG4B/PIK3C3/ATG2B/ATG101/ATG5/ATG4A/ATG13/PIK3R4/ATG9A	2.17123735472601
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	49/2270	158/9376	1.28094574248592	CDKN1A/PPP2R1B/CCND3/SMAD3/YWHAG/WEE1/GADD45A/PPP2R5A/ZBTB17/MYC/PPP2R5C/E2F3/ABL1/YWHAQ/CDC27/PPP2R5E/CUL1/TFDP2/SMAD2/CCNH/PDS5A/ANAPC16/ANAPC7/HDAC1/ATR/ANAPC5/SMAD4/STAG1/RBL2/GSK3B/CDK7/CDC14A/CREBBP/MAD2L2/MDM2/ORC2/YWHAZ/PPP2R5B/FZR1/EP300/ATRX/TGFB2/ANAPC1/CDC7/DBF4B/MAD1L1/ORC3/CDK2/GADD45G	2.01288337026205
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	42/2270	133/9376	1.30433572919082	AKT3/GNG12/PPP2R1B/CREB5/PLCB4/PPP3CA/MAOB/GNB5/PPP2R3A/MAOA/PPP2R5A/GNAQ/PPP3CC/PPP2R5C/ITPR3/PPP2R5E/PLCB1/GNAI3/GNAL/CACNA1C/CAMK2D/CREB3L2/MAPK11/ATF2/MAPK12/ATF6B/MAPK8/PPP2R2D/PPP3CB/GNB1/GSK3A/GSK3B/ATF4/ITPR1/GNB4/PLCB3/PPP2R5B/AKT2/PPP1CB/ARRB1/LRTOMT/GNAO1	1.99782871482729
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	7/2270	14/9376	2.06519823788546	ST3GAL1/CHST1/ST3GAL3/B4GALT2/B4GALT4/B4GALT1/FUT8	2.25421898972591
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	37/2270	116/9376	1.31745404830624	ACTN1/RAPGEF4/PIK3R3/VCAM1/MYL9/PTK2B/PIK3CB/PXN/RAP1B/MSN/BCAR1/CTNNA1/THY1/PTPN11/PTK2/GNAI3/PLCG2/ICAM1/VCL/ESAM/MAPK11/MAPK12/ROCK1/ARHGAP35/F11R/RAPGEF3/PLCG1/CD99L2/ACTN4/RAP1A/ROCK2/CXCR4/PIK3CA/MYL12A/CLDN15/CLDN14/ITK	1.94442114943662
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	24/2270	70/9376	1.41613593455003	AKT3/LEPR/ACACB/ACSL4/IKBKB/PRKAG2/ACSL5/STAT3/TNFRSF1A/CPT1A/SOCS3/RELA/CAMKK2/PTPN11/ADIPOR2/NFKBIA/NFKBIB/MTOR/PRKAA1/MAPK8/AKT2/PRKAA2/IRS2/JAK2	1.97509814509429
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	40/2270	128/9376	1.29074889867841	PDE7B/PDE2A/PNP/PDE10A/PGM2/ENTPD1/ADA/AK2/PDE8A/NPR1/ENPP4/NME7/ADCY4/NT5E/ENTPD4/NME1/GMPR/HPRT1/AK3/PRPS2/GART/PAICS/ADK/PGM1/NT5C2/GUK1/PRPS1/PDE3A/AK9/PDE6D/NUDT9/PDE7A/AK1/AK4/FHIT/ADPRM/PPAT/ENTPD5/ADCY6/PRUNE1	1.87191066160556
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	47/2270	154/9376	1.26057554780022	RYR3/CDKN1A/NFATC1/PLCB4/MYL9/PTGS2/PRKAG2/NOS3/PPP3CA/NFATC2/PPP1R12B/CACNB2/EGFR/GNAQ/NPR1/PPP3CC/ITPR3/OXTR/CAMKK2/PLA2G4A/ADCY4/MAPK3/PPP1R12C/MAP2K1/CAMK1D/PLCB1/GNAI3/CACNA1C/CAMK2D/PRKAA1/KCNJ2/CACNA2D1/PPP3CB/MAPK1/ROCK1/ITPR1/PLCB3/PPP1CB/ELK1/PRKAA2/ROCK2/KCNJ14/PPP3R1/MAPK7/ADCY6/GNAO1/RCAN1	1.84275426969072
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	24/2270	71/9376	1.39619035800707	IKBKB/MET/ADAM17/EGFR/RELA/MAP3K14/CXCL2/PTPN11/NOD1/NFKBIA/PLCG2/HBEGF/MAPK11/MAPK12/ATP6V1E1/MAPK8/GIT1/ATP6V1D/F11R/PLCG1/CXCL1/ATP6V0A2/MAP2K4/CXCL3	1.8939166097646
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	34/2270	107/9376	1.31246243155338	FOXO1/AKT3/SIK2/CREB5/PFKP/ACACB/PLCB4/PRKAG2/PPP3CA/LDHA/PKM/CPT1A/GNAQ/PPP3CC/ITPR3/PLCB1/GYS1/CAMK2D/PRKAA1/CREB3L2/ATF2/PYGB/PPP3CB/PPP4R3B/CREBBP/ATF4/ITPR1/PLCB3/ACACA/AKT2/PFKM/EP300/PRKAA2/PPP3R1	1.83721177856271
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	28/2270	86/9376	1.34478024792542	LMNA/DES/ITGB4/SNTB2/ITGA6/TCF7L1/TCF7L2/ITGA5/ITGB3/CTNNA1/CACNB2/ITGA9/SGCD/ITGA10/NOS1/LEF1/ATP2A2/CACNA1C/ITGA8/ITGA2/CACNA2D1/JUP/DSP/ITGA1/ITGAV/ITGA11/DMD/ATP2A3	1.81538904962436
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	41/2270	134/9376	1.26377802616872	RAMP3/CALCRL/ACTG2/PRKCH/PLCB4/MYL9/MYH9/MYH11/PRKCE/ACTA2/PPP1R12B/GNAQ/NPR1/ITPR3/PLA2G4A/ADCY4/MAPK3/ADM/PPP1R12C/MAP2K1/PLCB1/BRAF/PLA2G12A/CACNA1C/GNA11/EDN1/MAPK1/ROCK1/CALD1/ARHGEF12/GNA12/ITPR1/PLCB3/ARHGEF1/PPP1CB/ARAF/KCNMA1/KCNMB1/PRKG1/ROCK2/ADCY6	1.73817699007606
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	11/2270	28/9376	1.62265575833858	ELOVL5/ELOVL7/ACOT7/HSD17B12/ELOVL1/HACD2/THEM4/HADHA/MECR/PPT2/HACD1	1.86489179357484
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	42/2270	138/9376	1.25707718827811	AR/PPP2R1B/SLK/PPP3CA/YWHAG/RPS6KA2/RPS6KA3/PPP2R5A/PPP3CC/PPP2R5C/ITPR3/ADCY4/YWHAQ/MAPK3/CPEB2/MAP2K1/CDC27/PPP2R5E/CUL1/FBXW11/ANAPC16/CPEB3/CAMK2D/ANAPC7/MAPK11/MAPK12/PPP3CB/MAPK1/ANAPC5/PGR/ITPR1/MAD2L2/BTRC/YWHAZ/PPP2R5B/PPP1CB/ANAPC1/MAD1L1/CDK2/PPP3R1/SPDYA/ADCY6	1.71949164819088
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	34/2270	109/9376	1.28838055207533	AKT3/PIK3R3/IKBKB/CD40/PIK3CB/STAT1/TBK1/JAK1/RELA/TICAM1/MAPK3/MAP2K1/IL6/STAT2/IRF3/NFKBIA/RIPK1/MAP2K3/MAPK11/IRAK4/MAPK12/MAPK8/MAPK1/IFNAR2/IFNAR1/TRAF6/IRF7/MAP2K4/AKT2/CASP8/TLR3/MAP2K6/PIK3CA/MAP2K7	1.71157368850128
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	24/2270	73/9376	1.35793856737674	MAP1B/MX1/CHMP4B/NUP153/KAT2B/ELL/AFF4/SUPT5H/TNPO3/CCNT2/HGS/CCNT1/CPSF7/TSG101/MX2/CREBBP/SERINC3/KAT2A/MDFIC/CDK9/EP300/APOBEC3G/CXCR4/ELL2	1.73517938891935
Human Diseases	Cancer: specific types	hsa05218	Melanoma	24/2270	73/9376	1.35793856737674	CDKN1A/AKT3/PDGFD/PIK3R3/FGF2/PIK3CB/MET/FGFR1/GADD45A/EGFR/E2F3/MAPK3/MAP2K1/BRAF/POLK/MAPK1/PDGFA/MDM2/AKT2/ARAF/PDGFB/PIK3CA/DDB2/GADD45G	1.73517938891935
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	13/2270	35/9376	1.5341472624292	PFKP/GMDS/HK1/PFKFB3/PMM2/ENOSF1/PFKM/TKFC/ALDOB/HK2/FPGT/ALDOC/HSD17B14	1.78930472296795
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	131/2270	480/9376	1.12725403817915	RYR3/APP/TUBB6/PLCB4/PTGS2/FZD6/CAPN2/MCU/PPP3CA/HIP1/COX7A1/FZD8/DNAH14/MAP1LC3A/TNFRSF1A/TBK1/PINK1/IFT57/UBE2G2/DDIT3/KLC1/GNAQ/PPP3CC/RELA/OPTN/ATXN3/ITPR3/LRRK2/WNT5B/UBC/CSNK1A1/UBE2G1/PSEN1/TUBB4B/MAPK3/MAP2K1/MT-ATP8/SQSTM1/PRKN/ERN1/BECN1/IL6/NOS1/UBE2L6/PLCB1/VCP/PSMD11/ATP2A2/SNCA/EIF2S1/BRAF/MAP1LC3B/PSMD14/CACNA1C/MTOR/ALS2/LRP5/CAMK2D/RB1CC1/ATF6/NDUFV1/PIK3C3/CSNK1E/ATG2B/MAP2K3/MAPK11/DKK1/TARDBP/FUS/DERL1/ATG101/MAPK12/MAPK8/ATXN2L/PSMD13/PPP3CB/AMBRA1/UBE2J1/MAPK1/AXIN1/TUBA1C/WNT5A/UBA1/WNT2B/RAB5A/GSK3B/BCL2/CASP7/DNAH6/CHMP2B/PSMC6/SDHA/ATF4/ITPR1/PLCG1/ULK1/MFN2/ZFYVE1/DAXX/DCTN1/ATG13/PLCB3/FZD4/ATXN2/WDR41/MFN1/ARAF/GPX3/ACTR1B/DLG4/DNAL1/CASP8/WNT9B/ATXN1/MAP3K10/DVL1/PIK3R4/NOX4/CASP9/RAB8A/STX1A/KLC4/TUBB3/PPP3R1/MAP2K6/MAP2K7/TUBA4A/DNAH1/ATP2A3/KLC2/ATXN1L	1.61763587383293
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	36/2270	117/9376	1.27089122331413	BAZ1A/MBD2/INO80D/BAZ2A/GATAD2B/INO80C/GATAD2A/CDK2AP1/SMARCC1/SMARCA2/EP400/SMARCA4/CDK2AP2/SMARCC2/ARID1B/HDAC1/MORF4L2/BICRAL/SRCAP/BAZ1B/CHD4/BAZ2B/INO80/RBBP4/MTA3/SMARCA5/ARID2/BCL7B/RSF1/EPC2/MORF4L1/MTA2/PHF10/SS18L1/ING3/INO80B	1.66644808451752
Human Diseases	Immune disease	hsa05310	Asthma	12/2270	32/9376	1.5488986784141	HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DRA/CD40/HLA-DQA2/HLA-DQA1/HLA-DOA/HLA-DQB2	1.7578698791349
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	32/2270	103/9376	1.28322997305504	ACTN1/LAMA3/PIK3R3/HSPB1/PLCB4/LAMB1/PIK3CB/IL1R1/GNA14/GNAQ/RELA/CXCL2/PTK2/IL6/PLCB1/GNAL/LAMA4/GNA11/VCL/RAB5A/LAMB2/RAB7A/LAMA5/CXCL1/RAB5B/PLCB3/CXCL3/ACTN4/TGFB2/PIK3CA/LAMB3/IFNG	1.6335546142381
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	43/2270	144/9376	1.23338228095937	RORA/AKT3/PIK3R3/PLCB4/PIK3CB/MCU/GNAQ/ATXN3/ITPR3/KCND3/PUM1/SP1/ERN1/BECN1/PLCB1/PSMD11/ATP2A2/PSMD14/MTOR/RB1CC1/RELN/PIK3C3/ATG2B/ATG101/MAPK8/ATXN2L/PSMD13/AMBRA1/OPA1/PSMC6/ITPR1/ULK1/ATG13/PLCB3/ATXN2/AKT2/TBPL1/ATXN1/PIK3R4/PIK3CA/ATP2A3/TBP/ATXN1L	1.59509734977203
Organismal Systems	Nervous system	hsa04730	Long-term depression	20/2270	60/9376	1.37679882525697	PPP2R1B/PLCB4/GNAQ/ITPR3/PLA2G4A/MAPK3/MAP2K1/NOS1/PLCB1/GNAI3/BRAF/GNA11/MAPK1/GNA12/ITPR1/GNAZ/PLCB3/ARAF/PRKG1/GNAO1	1.6548414506154
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	13/2270	36/9376	1.49153206069506	PGM2/HK1/PGM2L1/GPI/GYG1/GBE1/GYS1/AGL/PGM1/GANC/PYGB/UGP2/HK2	1.66999675742673
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	17/2270	50/9376	1.40433480176211	HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQB1/IL15/HLA-DMA/HLA-DRA/CD40/HLA-DQA2/HLA-DQA1/IL15RA/MAP3K14/HLA-DOA/IL6/CXCR4/HLA-DQB2	1.62018417233973
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	24/2270	75/9376	1.3217268722467	CDKN1A/AKT3/PIK3R3/PIK3CB/MAPK3/MLH1/REV3L/BIRC3/MAPK1/ERCC1/TOP2B/BCL2/GSTM3/MGST1/MDM2/AKT2/CASP8/GSTT2B/ERBB2/POLH/CASP9/PIK3CA/GSTO2/BRCA1	1.58102636271102
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	9/2270	23/9376	1.61624209921471	LARGE1/B3GALNT2/ST3GAL3/B4GALT2/FKTN/POMT1/RXYLT1/B4GALT1/POMK	1.67234463136366
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	18/2270	54/9376	1.37679882525697	HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-F/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/HLA-DRA/CD40/HLA-A/HLA-C/HLA-E/HLA-DQA2/HLA-DQA1/HLA-DOA/HLA-G/HLA-DQB2	1.56941513301737
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	21/2270	65/9376	1.33443578447984	PBX1/CREB5/LDLR/PLCB4/NR4A1/PDE8A/GNAQ/ITPR3/ADCY4/SP1/PLCB1/CACNA1C/GNA11/CREB3L2/ATF2/ATF6B/ATF4/ITPR1/PLCB3/NCEH1/ADCY6	1.52917511100056
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	21/2270	65/9376	1.33443578447984	AKT3/GABBR1/PIK3R3/KCNN3/PLCB4/PIK3CB/GNAQ/ITPR3/MAPK3/MAP2K1/PLCB1/CACNA1C/GNA11/TRPC4/MAPK1/ITPR1/PLCB3/AKT2/ARRB1/ESR2/PIK3CA	1.52917511100056
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	30/2270	98/9376	1.26440708441967	PDE2A/ATP1A1/ATP2B4/CREB5/LDLR/PLCB4/NR4A1/PRKD1/PRKD2/PRKCE/GNAQ/NPR1/ITPR3/ATP2B1/ADCY4/DAGLB/CAMK1D/PRKD3/PLCB1/CACNA1C/CAMK2D/GNA11/CREB3L2/ATF2/ATF6B/ATF4/ITPR1/PLCB3/ATF1/ADCY6	1.48711620545636
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	33/2270	110/9376	1.23911894273128	AKT3/PIK3R3/PIK3CB/RPS6KA2/RPS6KA3/ADCY4/MAPK3/CPEB2/MAP2K1/CDC27/GNAI3/BRAF/ANAPC16/CPEB3/HSP90AB1/ANAPC7/MAPK11/MAPK12/MAPK8/MAPK1/ANAPC5/PGR/MAD2L2/KIF22/AKT2/FZR1/ARAF/ANAPC1/MAD1L1/CDK2/PIK3CA/SPDYA/ADCY6	1.42577219725424
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	16/2270	48/9376	1.37679882525697	OXCT1/MCCC1/ALDH2/BCKDHB/MCCC2/PCCA/HMGCS1/HADHA/AUH/BCAT2/AACS/ACADSB/ALDH6A1/ALDH3A2/EHHADH/ACAD8	1.47918282431951
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	46/2270	160/9376	1.18748898678414	HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-F/ALCAM/VCAM1/HLA-DPB1/HLA-B/HLA-DQB1/HLA-DMA/PTPRM/HLA-DRA/SELE/ITGA6/CD40/HLA-A/NLGN1/HLA-C/HLA-E/HLA-DQA2/HLA-DQA1/PVR/ITGA9/NECTIN2/SELP/HLA-DOA/CD274/NECTIN3/SDC4/ITGA8/ICAM1/ESAM/CADM1/PTPRF/NRXN3/F11R/PDCD1LG2/CD99L2/ITGAV/HLA-G/CD2/HLA-DQB2/CLDN15/CLDN14/NLGN2/CD22	1.35191842068146
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	11/2270	31/9376	1.46562455591872	PFKP/PGM2/GPI/PRPS2/PGM1/PRPS1/PFKM/RBKS/ALDOB/ALDOC/IDNK	1.46761801869423
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	20/2270	63/9376	1.31123697643521	CDKN1A/FZD6/TCF7L1/TCF7L2/FZD8/GADD45A/BMP2/WNT5B/LEF1/POLK/AXIN1/WNT5A/WNT2B/GSK3B/FZD4/WNT9B/DVL1/BMP4/DDB2/GADD45G	1.40088545484527
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	26/2270	85/9376	1.26341539258875	PNP/UPP1/UCK2/CDA/ENTPD1/ADA/AK2/NME7/NT5E/ENTPD4/NME1/GMPR/HPRT1/AK3/CMPK1/NT5C3A/ADK/NT5C2/GUK1/ASMTL/AK9/CTPS1/AK1/CTPS2/AK4/ENTPD5	1.37881292951539
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	30/2270	100/9376	1.23911894273128	HLA-DRB1/CD55/HLA-DRB5/HLA-DPA1/HLA-DPB1/IL4R/HLA-DQB1/HLA-DMA/IL3RA/HLA-DRA/ITGA6/CD59/CSF3/IL1R1/ITGA5/ITGB3/HLA-DQA2/HLA-DQA1/HLA-DOA/IL6/IL6R/ITGA2/FLT3LG/ITGA1/IL7/IL7R/IL11RA/CD2/HLA-DQB2/CD22	1.35868749106375
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	14/2270	42/9376	1.37679882525697	ACSL4/SLC39A14/ACSL5/MAP1LC3A/SLC3A2/GCLC/MAP1LC3B/SAT2/GCLM/TF/ATG5/SLC39A8/HMOX1/SAT1	1.38320405125824
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	44/2270	154/9376	1.18011327879169	RFK/GCH1/MAT2A/AK2/DHRS3/MTHFD1L/NME7/GPHN/ALDH2/RDH11/PMM2/NME1/PTS/GCLC/VKORC1/AK3/CMPK1/TPK1/NMNAT3/GCLM/UGDH/VKORC1L1/FPGS/AK9/BCAT2/UGP2/SPR/COQ7/CTPS1/AK1/CTPS2/MMAB/AK4/PPOX/NADSYN1/ALDH3A2/MOCS1/MTHFD2L/NFS1/NMNAT1/NQO1/COQ6/RDH13/UGT2B7	1.27373622092836
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	44/2270	154/9376	1.18011327879169	RAPGEF4/AKT3/ATP1A1/PPP2R1B/ATP2B4/CREB5/PLCB4/PPP2R3A/CACNB2/PPP2R5A/GNAQ/PPP2R5C/TPM4/ATP2B1/ADCY4/MAPK3/PPP2R5E/PLCB1/TPM2/ATP2A2/GNAI3/CACNA1C/CAMK2D/CREB3L2/MAPK11/ATF2/MAPK12/ATF6B/PPP2R2D/CACNA2D1/MAPK1/TPM3/BCL2/RAPGEF3/ATF4/PLCB3/PPP2R5B/AKT2/PPP1CB/POPDC2/TPM1/SLC9A1/ATP2A3/ADCY6	1.27373622092836
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	7/2270	18/9376	1.60626529613314	TCN2/CD320/ZNF76/ZNF143/MMAB/HCFC1/ABCD4	1.4551018952745
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	18/2270	57/9376	1.30433572919082	ACSL4/ELOVL5/ELOVL7/ACSL5/CPT1A/HSD17B12/ELOVL1/HACD2/HADHA/MECR/ACACA/ACADSB/CBR4/PPT2/HACD1/ACOX3/EHHADH/ACOX1	1.3025418293356
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/2270	32/9376	1.41982378854626	ACACB/LDHA/BCKDHB/PCCA/ACSS2/HADHA/ACACA/ALDH6A1/ACOX3/EHHADH/ACOX1	1.34450240354379
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	6/2270	15/9376	1.65215859030837	ST6GALNAC3/ST3GAL1/ST6GALNAC6/SLC33A1/ST6GALNAC4/HEXB	1.42864291368791
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	20/2270	65/9376	1.27089122331413	LPIN1/PNPLA2/AGPAT4/PLPP3/GPAT3/MGLL/ALDH2/PLPP1/DGKE/PLPP5/LPIN2/GPAT4/DGAT1/DGKA/AGPAT3/AGK/TKFC/ALDH3A2/DGKI/DGKQ	1.23862378281304
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	17/2270	54/9376	1.30031000163159	REV1/MLH1/HES1/REV3L/FANCL/ATR/FANCC/POLK/ERCC1/TOP3A/RPA1/POLH/WDR48/FAAP100/ATRIP/ERCC4/BRCA1	1.25082943354627
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	5/2270	12/9376	1.72099853157122	VKORC1/VKORC1L1/COQ7/NQO1/COQ6	1.41247336129459
Organismal Systems	Endocrine system	hsa04924	Renin secretion	21/2270	69/9376	1.25707718827811	AQP1/PLCB4/PPP3CA/GNAQ/NPR1/PPP3CC/ITPR3/PLCB1/GNAI3/CACNA1C/KCNJ2/EDN1/PPP3CB/PDE3A/ITPR1/PLCB3/KCNMA1/ACE/PPP3R1/ADCY6/REN	1.2113487483507
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	7/2270	19/9376	1.52172501738929	IDS/HYAL1/HGSNAT/GNS/HEXB/IDUA/HYAL2	1.28657797720691
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	33/2270	115/9376	1.18524420609079	AKT3/GNG12/CREB5/PIK3R3/PLCB4/PIK3CB/GNB5/GNAQ/ITPR3/ADCY4/MAPK3/MAP2K1/PLCB1/GNAI3/CACNA1C/CAMK2D/GNA11/KCNJ2/CREB3L2/MAPK1/GNB1/BCL2/ATF4/ITPR1/GNB4/PLCB3/AKT2/FYN/JAK2/KCNJ14/PIK3CA/ADCY6/GNAO1	1.1296673496047
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	26/2270	89/9376	1.2066326783151	PDGFD/TUBB6/PLCB4/EGFR/GNAQ/ITPR3/TUBB4B/ADCY4/MAPK3/MAP2K1/CSNK1D/PLCB1/GNAI3/GNA11/MAPK1/TUBA1C/SOS2/PDGFA/ITPR1/PLCB3/PRKG1/TUBB3/PDGFB/MAPK7/TUBA4A/ADCY6	1.10698631171565
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	18/2270	59/9376	1.26012095870977	UPP1/DPYD/UCK2/CDA/ENTPD1/NME7/NT5E/ENTPD4/NME1/CMPK1/NT5C3A/NT5C2/ASMTL/AK9/CTPS1/CTPS2/CDADC1/ENTPD5	1.13278964205619
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/2270	37/9376	1.33958804619598	VCAM1/PLCB4/SELE/APOL1/GNAQ/IL6/PLCB1/LAMA4/ICAM1/PLCB3/APOA1/IFNG	1.1697391723138
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	29/2270	101/9376	1.18595542373621	PLCB4/FZD6/TCF7L1/TCF7L2/FZD8/GNAQ/WNT5B/ADCY4/MAPK3/MAP2K1/PLCB1/LEF1/GNAI3/CAMK2D/CREB3L2/EDN1/MAPK1/WNT5A/WNT2B/GSK3B/CREBBP/PLCB3/FZD4/EP300/WNT9B/MC1R/DVL1/ADCY6/GNAO1	1.0619364867655
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	11/2270	34/9376	1.33630474216118	POLR2J3/POLR2H/POLR1C/POLR3C/POLR2B/POLR2A/POLR3E/CRCP/POLR2D/POLR1B/POLR3A	1.11029525427147
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	9/2270	27/9376	1.37679882525697	ELOVL5/ELOVL7/ACOT7/HSD17B12/ELOVL1/HACD2/HACD1/ACOX3/ACOX1	1.10814044870962
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/2270	13/9376	1.58861402914266	XRCC6/DCLRE1C/MRE11/NHEJ1/RAD50	1.20027493965027
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	24/2270	83/9376	1.19433151106629	FAR2/ACSL4/ACSL5/SOD2/FAR1/PEX26/EPHX2/HACL1/PHYH/PEX5/SLC25A17/ABCD4/PEX14/CROT/PEX7/PEX10/CRAT/PEX19/DHRS4/ACOX3/MPV17L2/EHHADH/DDO/ACOX1	1.00505602288853
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	24/2270	83/9376	1.19433151106629	IKBKB/MLKL/IL33/TBK1/RELA/POLR2H/ADAR/CGAS/IL6/IRF3/NFKBIA/NFKBIB/G3BP1/POLR1C/POLR3C/RIPK1/IFI16/CASP7/IRF7/POLR3E/AIM2/CASP8/DDX41/POLR3A	1.00505602288853
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	37/2270	133/9376	1.14905766619191	NFATC1/PIK3R3/HLA-B/SHC1/PTK2B/PIK3CB/HLA-A/PPP3CA/TNFRSF10B/HLA-C/HLA-E/TNFRSF10A/NFATC2/PPP3CC/MAPK3/MAP2K1/PTPN11/BRAF/PLCG2/ICAM1/PPP3CB/MAPK1/IFNAR2/SH3BP2/IFNAR1/SOS2/PLCG1/MICA/ARAF/FYN/KLRD1/PPP3R1/MICB/PIK3CA/HLA-G/LCK/IFNG	0.978497288094054
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/2270	20/9376	1.44563876651982	SOAT1/HSD17B7/DHCR24/MSMO1/DHCR7/CYP51A1/LSS	1.12755781654468
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	16/2270	53/9376	1.24691214362896	DNM3/ATP1A1/ATP2B4/PLCB4/BDKRB2/GNAQ/AP2B1/ATP2B1/RAB11A/PLCB1/AP2A1/CLTB/DNM2/CLTCL1/PLCB3/ADCY6	1.01879899488604
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	26/2270	91/9376	1.18011327879169	AKT3/NFATC1/PIK3R3/IKBKB/IFITM1/PIK3CB/PPP3CA/NFATC2/BCL10/PPP3CC/RELA/MALT1/MAPK3/MAP2K1/CD79B/NFKBIA/NFKBIB/PLCG2/PPP3CB/MAPK1/SOS2/GSK3B/AKT2/PPP3R1/PIK3CA/CD22	0.975801406048408
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/2270	31/9376	1.3323859599261	DPYD/ALDH2/CSAD/HADHA/AOC3/ALDH6A1/ALDH3A2/ACOX3/EHHADH/ACOX1	1.04765871504785
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	28/2270	99/9376	1.16819294264228	PRKCH/PIK3R3/PLCB4/BDKRB2/PIK3CB/IL1R1/PRKCE/GNAQ/ITPR3/PLA2G4A/ADCY4/HRH1/PLCB1/CAMK2D/PLCG2/MAP2K3/MAPK11/MAPK12/MAPK8/ITPR1/PLCG1/IL1RAP/PLCB3/PPP1CB/BDKRB1/MAP2K6/PIK3CA/ADCY6	0.950840240274664
Organismal Systems	Digestive system	hsa04978	Mineral absorption	18/2270	61/9376	1.2188055174406	ATP1A1/MT2A/MT1X/ATP2B4/MT1G/MT1M/MT1E/TRPM6/SLC30A1/HEPH/MT1A/MT1F/ATP2B1/CYBRD1/MT1H/TF/TRPM7/HMOX1	0.968986490389427
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/2270	24/9376	1.37679882525697	EXT1/HS3ST1/NDST1/GLCE/EXT2/HS2ST1/HS3ST2/XYLT1	1.04459724745811
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	6/2270	17/9376	1.45778699144856	TXNRD1/KYAT3/KYAT1/SCLY/CTH/TXNRD3	1.0677243565299
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	101/2270	388/9376	1.07518052590944	BACE2/RYR3/INSR/APP/AKT3/TUBB6/PIK3R3/PLCB4/SLC39A14/IKBKB/PTGS2/FZD6/CAPN2/PIK3CB/MCU/PPP3CA/COX7A1/FZD8/TNFRSF1A/ADAM17/DDIT3/KLC1/GNAQ/PPP3CC/RELA/ITPR3/WNT5B/CSNK1A1/PSEN1/TUBB4B/MAPK3/MAP2K1/MT-ATP8/ERN1/BECN1/IL6/NOS1/PLCB1/PSMD11/ATP2A2/SNCA/EIF2S1/BRAF/RTN3/PSMD14/CACNA1C/MTOR/LRP5/IDE/RB1CC1/ATF6/NDUFV1/PIK3C3/SLC39A11/CSNK1E/ATG2B/DKK1/EIF2AK2/ATG101/MAPK8/PSMD13/PPP3CB/AMBRA1/MAPK1/AXIN1/TUBA1C/WNT5A/WNT2B/SLC39A9/GSK3B/CASP7/PSMC6/SDHA/ATF4/ITPR1/ULK1/ATG13/SLC39A8/APH1B/PLCB3/APBB1/FZD4/AKT2/SLC39A7/ARAF/CASP8/WNT9B/IRS2/DVL1/PIK3R4/NOX4/CASP9/KLC4/TUBB3/PPP3R1/PIK3CA/GAPDH/MAP2K7/TUBA4A/ATP2A3/KLC2	0.854821930627701
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	20/2270	69/9376	1.19721636978867	AKT3/PIK3R3/PIK3CB/PLA2G4A/MAPK3/MAP2K1/PLCG2/MAP2K3/MAPK11/MAPK12/MAPK8/MAPK1/SOS2/PLCG1/MAP2K4/AKT2/FYN/MAP2K6/PIK3CA/MAP2K7	0.929284330118539
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	9/2270	28/9376	1.32762743864065	GCNT2/A4GALT/ABO/B3GNT5/ST3GAL3/B4GALT2/ST3GAL6/B4GALT4/B4GALT1	0.981264066843604
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/2270	21/9376	1.37679882525697	CHSY1/CHST15/CHST11/CHST7/CHST3/XYLT1/UST	0.976974563985208
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	10/2270	32/9376	1.29074889867841	PFKP/PGM2/HK1/PGM1/GANC/UGP2/PFKM/B4GALT2/HK2/B4GALT1	0.931134927952677
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	29/2270	105/9376	1.14077616949864	LMNA/DES/ITGB4/SNTB2/ITGA6/ITGA5/ITGB3/CACNB2/ITGA9/SGCD/TPM4/ADCY4/ITGA10/NOS1/TPM2/ATP2A2/CACNA1C/ITGA8/ITGA2/CACNA2D1/TPM3/ITGA1/ITGAV/ITGA11/TGFB2/DMD/TPM1/ATP2A3/ADCY6	0.819872780361505
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/2270	18/9376	1.37679882525697	ACACB/ACSL4/ACSL5/MECR/ACACA/CBR4	0.90435769334919
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	21/2270	75/9376	1.15651101321586	THBS1/SESN3/SERPINE1/CDKN1A/CCND3/TNFRSF10B/TNFRSF10A/GADD45A/PPM1D/PPP1R13L/ZNF385A/PERP/ATR/BCL2/MDM2/CASP8/GORAB/CASP9/CDK2/DDB2/GADD45G	0.769124556555992
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	13/2270	45/9376	1.19322564855604	ABCB1/ABCG2/ABCC4/TAP1/TAP2/ABCA5/ABCG1/ABCB4/ABCC1/ABCD4/ABCC3/ABCA2/ABCB8	0.734332756124635
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	8/2270	26/9376	1.27089122331413	TCN2/BTD/APOB/ABCC1/ABCD4/APOA1/SLC19A2/SLC19A3	0.781738980697261
NA	NA	hsa04519	Cadherin signaling	103/2270	404/9376	1.05304662624853	CDH13/ACTN1/WWTR1/PCDH17/DES/TEAD4/MYO1D/MYO1E/TEAD1/IKBKB/PCDH7/FZD6/PTK2B/TCF7L1/YWHAG/TCF7L2/RRAS2/FZD8/MET/LIMA1/LHFPL2/ENAH/FGFR1/CTNNA1/TEAD2/EGFR/ARPC5L/FAT4/RELA/CELSR1/NCKAP1/CDH24/WNT5B/SCN3B/CSNK1A1/CDH23/PSEN1/SAV1/YWHAQ/MYO1C/MAPK3/PCDH19/ATN1/MAP2K1/GABRE/LATS2/PTK2/LEF1/NFKBIA/AMOTL1/YAP1/ERBIN/LRP5/VCL/SHOC2/MAP2K3/MAPK11/FLT4/STK3/MPDZ/ANKRD6/MAPK12/MAPK8/JUP/MAPK1/AXIN1/ROCK1/WNT5A/WNT2B/DSP/ARHGAP35/RYK/GSK3B/WTIP/MRAS/CREBBP/WASF1/PRICKLE2/PCDH1/ACTR3/APH1B/YWHAZ/FZD4/LHFPL6/PPP1CB/PCDHB4/LIMD1/EP300/ACTN4/CDH26/TAOK1/DAAM1/WNT9B/ERBB2/ROCK2/DVL1/TMC1/ACTR3B/LHFPL3/PRICKLE4/PRICKLE3/PCDHB3/LHFPL5	0.61601286673522
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	5/2270	15/9376	1.37679882525697	AK2/TPK1/AK1/AK4/NFS1	0.825429549789059
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	9/2270	30/9376	1.23911894273128	IKBKB/ABCG2/ABCC4/RELA/IL6/GART/FPGS/ABCC1/ABCC3	0.741391642480824
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	44/2270	168/9376	1.08177050555905	MLKL/CAPN2/IL33/TNFRSF10B/STAT3/TNFRSF10A/STAT1/CFLAR/TNFAIP3/TNFRSF1A/JAK1/CHMP3/CHMP4B/STAT5A/PLA2G4A/STAT5B/TICAM1/SQSTM1/STAT6/STAT2/GLUD1/BIRC3/CAMK2D/HSP90AB1/RBCK1/SPATA2L/RIPK1/EIF2AK2/PYGB/MAPK8/IFNAR2/IFNAR1/BCL2/CHMP2B/TRAF5/TRPM7/CHMP4C/CASP8/TLR3/JAK2/AIFM1/RNF31/IFNG/PGAM5	0.604441999595109
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	7/2270	23/9376	1.25707718827811	ASS1/NOS3/ASL/GLS/NOS1/GLUD1/GOT1	0.697650576308916
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	14/2270	50/9376	1.15651101321586	NOS3/MAOB/MAOA/ALDH2/NOS1/P4HA1/SAT2/GOT1/ALDH3A2/ALDH18A1/AZIN2/CKB/ODC1/SAT1	0.627145289755143
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	14/2270	50/9376	1.15651101321586	ACKR1/THBS1/VCAM1/SELE/CD40/CSF3/MET/SELP/IL6/ICAM1/THBS3/THBS2/TGFB2/IFNG	0.627145289755143
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	23/2270	86/9376	1.10464091793874	RAPGEF4/ATP1A1/CREB5/KCNN3/PLCB4/GNAQ/ITPR3/ADCY4/PLCB1/VAMP2/CACNA1C/CAMK2D/GNA11/CREB3L2/ATF2/ATF6B/ATF4/PLCB3/TRPM4/KCNMA1/KCNMB1/STX1A/ADCY6	0.55097116993116
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/2270	43/9376	1.15266878393607	ACSL4/ACSL5/CPT1A/ALDH2/CYP2U1/HADHA/ACADSB/ALDH3A2/ECI1/ACOX3/EHHADH/ACOX1	0.567100207749903
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	16/2270	59/9376	1.12010751885313	INSR/AKT3/PIK3R3/PTGS2/PIK3CB/PNPLA2/NPR1/MGLL/ADCY4/GNAI3/PTGER3/AKT2/IRS2/PRKG1/PIK3CA/ADCY6	0.523051098860896
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	20/2270	75/9376	1.10143906020558	ATP1A1/CREB5/PLCB4/ALB/GNAQ/ITPR3/ADCY4/PLCB1/CREB3L2/ATF2/ATF6B/ATF4/ITPR1/PLCB3/TTF2/GPX3/TTF1/ASGR1/ADCY6/TTR	0.498490621170982
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	9/2270	32/9376	1.16167400881057	TNFRSF1A/BECN1/BIRC3/MAPK8/BCL2/CASP7/CASP8/CASP9/BCL2L11	0.517767452361564
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	12/2270	44/9376	1.12647176611934	POLE4/APTX/PARP4/TDG/NEIL1/PNKP/POLB/RFC1/RFC2/POLD3/OGG1/XRCC1	0.475246056349271
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	30/2270	116/9376	1.06820598511317	GNG12/SHANK3/PLCB4/PPP3CA/GNB5/HOMER1/SLC1A1/GLS/GNAQ/PPP3CC/SLC38A1/ITPR3/PLA2G4A/ADCY4/MAPK3/PLCB1/GNAI3/CACNA1C/PPP3CB/MAPK1/GNB1/ITPR1/PLD2/GNB4/PLCB3/DLG4/PPP3R1/DLGAP1/ADCY6/GNAO1	0.417764903864984
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/2270	17/9376	1.2148224928738	CYP39A1/CYP7B1/CYP27A1/HSD3B7/CYP46A1	0.501043525168847
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	5/2270	17/9376	1.2148224928738	GGT5/CSAD/FMO2/CDO1/FMO4	0.501043525168847
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	25/2270	97/9376	1.06453517416776	RYR3/GNG12/PLCB4/PER1/GNB5/GNAQ/ITPR3/PER2/ADCY4/MAPK3/NOS1/PLCB1/GNAI3/CACNA1C/CAMK2D/PER3/MAPK1/GNB1/ITPR1/GNB4/PLCB3/PRKG1/RASD1/ADCY6/GNAO1	0.361091887529223
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	18/2270	69/9376	1.07749473280981	CREB5/PPP3CA/MAOB/MAOA/PPP3CC/FOSB/CACNA1C/CAMK2D/CREB3L2/HDAC1/ATF2/ATF6B/PPP3CB/ARC/ATF4/PPP1CB/STX1A/PPP3R1	0.365155493654219
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	9/2270	33/9376	1.12647176611934	ACO1/BCKDHB/DLST/OGDH/CS/BCAT2/IDH3A/GOT1/DHTKD1	0.411332802067878
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	10/2270	37/9376	1.11632337182998	ASS1/ASRGL1/ASL/GLS/GLUD1/GOT1/GFPT2/ALDH5A1/PPAT/DDO	0.400685495880579
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	20/2270	78/9376	1.05907601942844	ITGA5/SERPING1/IRF1/RELA/TICAM1/MAPK3/IL6/IRF3/NOD1/GNAI3/C1S/MAPK11/IRAK4/MAPK12/MAPK8/MAPK1/C3/CASP7/TRAF6/CFL2	0.296107713184055
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	10/2270	38/9376	1.08694644099235	PNP/NNMT/NT5E/NMNAT3/NT5C2/SIRT5/SIRT7/NADSYN1/SARM1/NMNAT1	0.303530710372423
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	10/2270	38/9376	1.08694644099235	INSR/ATP1A1/NR3C2/PIK3R3/PIK3CB/NEDD4L/MAPK3/MAPK1/SCNN1B/PIK3CA	0.303530710372423
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	24/2270	95/9376	1.04346858335265	HLA-DRB1/HLA-DRB5/HLA-DPA1/FLT1/HLA-DPB1/HLA-DQB1/IL15/HLA-DMA/HLA-DRA/VEGFA/HLA-DQA2/HLA-DQA1/CXCL2/HLA-DOA/IL6/ICAM1/ATP6V1E1/ATP6V1D/CXCL1/ATP6V0A2/CXCL3/TGFB2/HLA-DQB2/IFNG	0.240672166933509
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	19/2270	75/9376	1.0463671071953	ASS1/PFKP/PKM/MAT2A/ASL/ACO1/PRPS2/PRPS1/CS/BCAT2/IDH3A/GOT1/PFKM/ALDOB/ALDH18A1/ENO2/ALDOC/GAPDH/CTH	0.227856685785971
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	7/2270	27/9376	1.07084353075542	OXCT1/HMGCS1/HADHA/L2HGDH/AACS/ALDH5A1/EHHADH	0.208346143080331
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	6/2270	23/9376	1.07749473280981	MLH1/RFC1/MLH3/RPA1/RFC2/POLD3	0.210303548781543
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	14/2270	56/9376	1.03259911894273	MGAT4A/MAN2A1/ALG13/ST6GAL1/DPM3/STT3B/DAD1/GANAB/DHRSX/B4GALT2/ALG8/ALG6/B4GALT1/FUT8	0.138285895078348
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	53/2270	217/9376	1.00880651251548	AR/AKT3/CCND3/CREB5/PIK3R3/EPHX1/FGF2/PIK3CB/RPS6KA2/VEGFA/STAT3/BCL6/RPS6KA3/EGFR/STAT5A/MYC/AHR/RELA/STAT5B/ADCY4/MAPK3/KPNA1/MAP2K1/KPNA4/RPS6KB1/GNAI3/CACNA1C/MTOR/HSP90AB1/CREB3L2/KPNB1/KPNA6/DLL1/ATF2/ATF6B/MAPK1/EPHX2/SOS2/BCL2/ATF4/PGR/GSTM3/MGST1/PTGES3/AKT2/ARRB1/ESR2/GSTT2B/JAK2/PIK3CA/GSTO2/ADCY6/UGT2B7	0.0741815253587626
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	7/2270	28/9376	1.03259911894273	GCH1/AKR1C3/GPHN/PTS/FPGS/SPR/MOCS1	0.0976363401123679
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	28/2270	116/9376	0.996992252772292	PFKP/PKM/ME3/HK1/GPI/ACO1/GLUD1/PRPS2/DLST/PCCA/OGDH/PRPS1/CS/ACSS2/SDHA/IDH3A/GOT1/PFKM/ALDH6A1/TKFC/ALDOB/HK2/ENO2/ALDOC/GAPDH/IDNK/ACOX3/ACOX1	-0.0184225948697695
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	10/2270	41/9376	1.00741377457827	UIMC1/BARD1/RBBP8/BABAM2/TOP3A/RPA1/POLD3/MRE11/RAD50/BRCA1	0.0268880996659793
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	13/2270	54/9376	0.994354707130038	LDHA/MAT2A/GCLC/DNMT1/GCLM/BHMT2/BCAT2/GOT1/KYAT3/CDO1/KYAT1/AHCYL2/CTH	-0.0235133643380967
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/2270	16/9376	1.03259911894273	MAOB/MAOA/AOC3/GOT1	0.0737588088750984
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	4/2270	16/9376	1.03259911894273	A4GALT/ABO/ST3GAL1/HEXB	0.0737588088750984
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/2270	67/9376	0.986363337497534	PFKP/LDHA/PKM/PGM2/HK1/GPI/ALDH2/PGM1/ACSS2/PFKM/ALDOB/ALDH3A2/HK2/ENO2/ALDOC/GAPDH	-0.0633111122938509
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	10/2270	42/9376	0.983427732326411	MAOB/MAOA/ALDH2/DLST/HADHA/KYAT3/KYAT1/ALDH3A2/DHTKD1/EHHADH	-0.0608357198805261
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	18/2270	76/9376	0.978251796893114	ACSL4/ACSL5/APOA2/ME3/CPT1A/SORBS1/APOC3/UBC/PLIN2/SLC27A4/PPARD/CYP27A1/HMGCS1/APOA1/ANGPTL4/ACOX3/EHHADH/ACOX1	-0.107590683702161
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	9/2270	38/9376	0.978251796893114	CD40/TAP1/TAP2/CIITA/ADA/DCLRE1C/IL7R/LCK/RFX5	-0.0759231483544891
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	12/2270	51/9376	0.971857994299041	PAFAH1B2/ENPP2/PLPP3/PLA2G4A/PLPP1/PLA2G12A/SELENOI/LPCAT4/PAFAH1B1/LPCAT1/PLD2/CHPT1	-0.113894218692518
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/2270	21/9376	0.983427732326411	DPYD/ALDH2/CSAD/BCAT2/ALDH3A2	-0.0429690405048611
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	7/2270	30/9376	0.963759177679883	ACLY/ACO1/DLST/OGDH/CS/SDHA/IDH3A	-0.112365178926718
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	7/2270	30/9376	0.963759177679883	PIGK/PIGG/PGAP1/PIGB/PIGS/PIGH/PGAP2	-0.112365178926718
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	59/2270	250/9376	0.974773568281938	NCOA7/OSBPL1A/VPS13A/OSBPL5/IDS/LITAF/HYAL1/NPC1/AP2B1/AP3M2/RRAGC/ENTPD4/ABCA5/CTSF/SLC29A1/RPTOR/TFE3/VPS26A/OSBP/IGF2R/MTOR/VPS39/AP5Z1/OSBPL3/AP3S1/STX17/PLEKHM1/AP2A1/ATP6V1E1/ARSG/SLC36A4/LAPTM4B/TFEB/CLN5/HGSNAT/CLTB/CTSO/ATP6V1D/AP3B1/AP3D1/CLN8/RAB7A/OSBPL2/CLTCL1/ATP6V0A2/AP1G2/GNS/AP3S2/HEXB/ABCA2/TLR3/IDUA/HYAL2/MEAK7/PPT2/TTI1/AP4M1/GALC/AKT1S1	-0.22849229573828
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/2270	17/9376	0.971857994299041	CA13/CA8/GLUD1/CA5B	-0.0656373061922033
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/2270	17/9376	0.971857994299041	MYH9/PCDH7/MYH11/PCDH1	-0.0656373061922033
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/2270	52/9376	0.953168417485598	LDLR/OSBPL5/APOA2/NPC1/APOC3/SOAT1/VAPA/CYP27A1/APOB/APOA1/ANGPTL4/NCEH1	-0.191392686350178
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	53/2270	226/9376	0.968632801840084	RAPGEF4/AKT3/ATP1A1/NFATC1/TIAM1/GABBR1/ATP2B4/CREB5/PIK3R3/PDE10A/MYL9/ABCC4/PIK3CB/RAP1B/RRAS2/ARAP3/NPR1/RELA/OXTR/ATP2B1/ADCY4/MAPK3/MAP2K1/ATP2A2/NFKBIA/PLCE1/GNAI3/BRAF/CACNA1C/CAMK2D/CREB3L2/EDN1/MAPK8/PTGER3/MAPK1/ROCK1/PDE3A/CREBBP/RAPGEF3/PLD2/AKT2/PPP1CB/HTR1F/EP300/RAP1A/ROCK2/POPDC2/PIK3CA/SLC9A1/ATP2A3/ACOX3/ADCY6/ACOX1	-0.269777276080285
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	11/2270	48/9376	0.94654919236417	AKT3/ATP1A1/PIK3R3/PLCB4/PIK3CB/HK1/PLCB1/PLCB3/AKT2/HK2/PIK3CA	-0.209829519895675
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/2270	22/9376	0.938726471766119	MAOB/MAOA/ALDH2/CARNMT1/ALDH3A2	-0.162619084324792
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	10/2270	44/9376	0.938726471766119	MGAT4A/MAN2A1/ALG13/STT3B/DAD1/ST3GAL3/B4GALT2/HEXB/B4GALT1/FUT8	-0.230249039333244
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/2270	18/9376	0.91786588350465	GBA2/MAN2C1/MAN2B2/HEXB	-0.197130710501422
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/2270	49/9376	0.927231861907759	CREB5/MAOB/MAOA/RELA/FOSB/GNAI3/CREB3L2/ATF2/ATF6B/ATF4/DLG4	-0.288638513801096
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	20/2270	88/9376	0.938726471766119	VWF/PLAT/CD55/SERPINE1/CLU/F8/CFI/CFH/CD59/THBD/BDKRB2/SERPING1/PROCR/C1S/CFB/PROS1/TFPI/C3/F2RL3/BDKRB1	-0.326391685040333
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	86/2270	368/9376	0.965255698142119	TUBB6/MCU/PPP3CA/COX7A1/NUP98/DNAH14/MAP1LC3A/TNFRSF1A/TBK1/PINK1/DDIT3/NUP153/KLC1/PPP3CC/OPTN/UBQLN1/ITPR3/TUBB4B/MT-ATP8/SQSTM1/PRKN/ERN1/BECN1/NOS1/NXT1/VCP/PSMD11/EIF2S1/MAP1LC3B/PSMD14/SETX/MTOR/ALS2/RB1CC1/NUP188/ATF6/NDUFV1/PIK3C3/ATG2B/MAP2K3/NUP107/MAPK11/TARDBP/FUS/DERL1/ATG101/MAPK12/ATXN2L/PSMD13/PPP3CB/AMBRA1/TUBA1C/POM121/RAB5A/BCL2/DNAH6/CHMP2B/PSMC6/SDHA/NUP58/ATF4/ULK1/NUP88/DAXX/DCTN1/ATG13/NXF1/NUP205/ATXN2/WDR41/NUP155/GPX3/ACTR1B/DNAL1/HDAC6/NUP43/PIK3R4/CASP9/RAB8A/KLC4/TUBB3/PPP3R1/MAP2K6/TUBA4A/DNAH1/KLC2	-0.384307867448263
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	52/2270	227/9376	0.946170117797745	AKT3/PIK3R3/IKBKB/ABL2/EPHX1/PRKD1/PIK3CB/PRKD2/COX7A1/VEGFA/HIF1A/MET/AKR1C3/EGFR/SOD2/AHR/RELA/MAP3K14/ABL1/PTPN1/MAPK3/MAP2K1/MT-ATP8/PTPN11/PTK2/PRKD3/NFKBIA/NFE2L2/BRAF/NDUFV1/MAPK11/MAPK12/MAPK8/MAPK1/EPHX2/SOS2/FOXO3/SDHA/GSTM3/PLD2/MGST1/HMOX1/MAP2K4/AKT2/ARAF/GSTT2B/NOX4/PIK3CA/MAP2K7/GSTO2/AS3MT/NQO1	-0.464018728245165
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	71/2270	308/9376	0.952136849934207	TUBB6/CREB5/PLCB4/HIP1/COX7A1/TAF4B/DNAH14/SIN3A/TGM2/IFT57/KLC1/POLR2J3/SOD2/GNAQ/POLR2H/AP2B1/TUBB4B/SP1/MT-ATP8/ERN1/BECN1/PLCB1/PSMD11/POLR2B/PSMD14/MTOR/RB1CC1/CREB3L2/NDUFV1/PIK3C3/ATG2B/HDAC1/AP2A1/ATG101/MAPK8/POLR2A/PSMD13/AMBRA1/CLTB/TUBA1C/DNAH6/PSMC6/SDHA/CREBBP/ITPR1/ULK1/NRF1/DCTN1/ATG13/CLTCL1/PLCB3/EP300/GPX3/ACTR1B/DLG4/DNAL1/CASP8/TBPL1/MAP3K10/PIK3R4/CASP9/STX1A/KLC4/TUBB3/POLR2D/TAF4/MAP2K7/TUBA4A/DNAH1/TBP/KLC2	-0.482732841142615
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	4/2270	19/9376	0.869557152793879	BCKDHB/DLST/OGDH/DHTKD1	-0.32167308238228
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	58/2270	254/9376	0.943161399979188	RYR3/ITPKC/PDGFD/NFATC1/ASPH/ATP2B4/FLT1/VEGFC/PLCB4/FGF2/PTK2B/NOS3/BDKRB2/MCU/PPP3CA/VEGFA/SPHK1/NFATC2/MET/FGFR1/GNA14/EGFR/STIM1/GNAQ/PPP3CC/ITPR3/OXTR/ATP2B1/ADCY4/HRH1/CAMK1D/NOS1/PLCB1/ATP2A2/PLCE1/ORAI2/GNAL/CACNA1C/CAMK2D/PLCG2/GNA11/FLT4/PTGER3/TFEB/PPP3CB/PDGFA/STIM2/ITPR1/PLCG1/TACR1/PLCB3/BDKRB1/ERBB2/PLCD4/CXCR4/PPP3R1/PDGFB/ATP2A3	-0.519040398883874
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/2270	47/9376	0.878807760802324	ACACB/LDHA/PKM/ME3/ALDH2/ACYP1/ACYP2/ACSS2/ACACA/ALDH3A2	-0.47075198222244
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/2270	10/9376	0.826079295154185	SQOR/SUOX	-0.310999846950284
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/2270	157/9376	0.920789023261034	INSR/AKT3/LEPR/PIK3R3/IKBKB/PRKAG2/PIK3CB/COX7A1/TNFRSF1A/DDIT3/SOCS3/RELA/ERN1/IL6/IL6R/ADIPOR2/EIF2S1/PRKAA1/NDUFV1/MAPK11/MAPK12/MAPK8/MAP3K11/GSK3A/GSK3B/CASP7/SDHA/ATF4/ITCH/AKT2/CASP8/PRKAA2/IRS2/BCL2L11/PIK3CA	-0.565690978117618
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/2270	39/9376	0.847260815542754	MAT2A/MTHFD1L/GART/BHMT2/DMGDH/AHCYL2/MTHFD2L/CTH	-0.54021303186558
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	25/2270	115/9376	0.897912277341505	APP/GNG12/PLCB4/PTGS2/MAOB/GNB5/MAOA/GNAQ/ITPR3/PLA2G4A/MAPK3/MAP2K1/PLCB1/GNAI3/BRAF/CACNA1C/MAPK1/GNB1/RAPGEF3/ITPR1/GNB4/PLCB3/HTR1F/ARAF/GNAO1	-0.622557485151684
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	13/2270	63/9376	0.852304034682889	PTGIS/PTGS2/AKR1C3/PLA2G4A/LTC4S/PLA2G12A/GGT5/CBR3/EPHX2/PTGR1/CYP2U1/LTA4H/PTGES3	-0.664783252690221
NA	NA	hsa04981	Folate transport and metabolism	6/2270	31/9376	0.799431575955663	ABCG2/ABCC4/BHMT2/FPGS/ABCC1/ABCC3	-0.63217849953764
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	12/2270	59/9376	0.840080639139849	TXNDC12/PRDX6/GCLC/GCLM/GGT5/LANCL1/GSTM3/MGST1/GPX3/GSTT2B/GSTO2/ODC1	-0.696425987529695
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	7/2270	36/9376	0.803132648066569	POLE4/RFC1/POLA1/RPA1/RFC2/POLD3/DNA2	-0.668863469266113
Human Diseases	Substance dependence	hsa05032	Morphine addiction	19/2270	91/9376	0.86239047296316	PDE7B/PDE2A/GNG12/GABBR1/PDE10A/GNB5/GRK5/PDE8A/ADCY4/GABRE/GNAI3/GNB1/PDE3A/PDE7A/GNB4/ARRB1/GRK4/ADCY6/GNAO1	-0.74552843004709
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	21/2270	100/9376	0.867383259911894	CCL14/CCL21/ACKR3/TNFRSF10B/TNFRSF10D/TNFRSF10A/CX3CL1/TNFRSF1A/CCL23/CXCL2/IL6/IL6R/TNFRSF10C/ACKR4/IL34/IL18R1/CCL16/CXCL1/CXCL3/CXCR4/CCL15	-0.753535892243612
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/2270	46/9376	0.808121049607355	PSMB9/PSMB8/PSMD11/PSME4/PSMD14/PSMD13/PSMC6/PSME3/IFNG	-0.737312154630693
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/2270	12/9376	0.688399412628487	NPC1/ASGR1	-0.610441644127722
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	16/2270	79/9376	0.836535995092846	DNM3/UNC13B/CPLX1/SLC1A1/STXBP1/AP2B1/VAMP2/AP2A1/ATP6V1E1/CLTB/STX2/DNM2/ATP6V1D/CLTCL1/ATP6V0A2/STX1A	-0.82461310112313
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	21/2270	102/9376	0.850375745011661	ATP1A1/ATP2B4/PLCB4/RAP1B/GNAQ/ITPR3/ATP2B1/ADCY4/RAB11A/PLCB1/ATP2A2/PLA2G12A/SLC12A2/ITPR1/PLCB3/KCNMA1/RAP1A/RAB8A/SLC9A1/ATP2A3/ADCY6	-0.858725790177683
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/2270	23/9376	0.718329821873204	ZMPSTE24/HMGCS1/MVD/HMGCR	-0.764390506273202
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/2270	23/9376	0.718329821873204	ATP1A1/AQP1/GLS/GLUD1	-0.764390506273202
NA	NA	hsa04081	Hormone signaling	46/2270	219/9376	0.867571862490697	RAMP3/RAPGEF4/INSR/SMAD1/GNG12/LEPR/PIK3R3/PLCB4/PTHLH/PIK3CB/GHR/STAT3/ITGB3/GNB5/GNA14/HEPH/STAT5A/GNAQ/NPR1/OXTR/STAT5B/ADCY4/NOS1/PLCB1/ADIPOR2/THRB/GNAI3/GNA11/SMAD4/GNB1/AVPR2/RAPGEF3/GNA12/GNB4/PLCB3/ITGAV/ESR2/IRS2/PRKG1/JAK2/MC1R/PIK3CA/ADRA2C/SLCO1C1/ADCY6/GNAO1	-1.12075758477053
Organismal Systems	Digestive system	hsa04970	Salivary secretion	18/2270	93/9376	0.799431575955663	RYR3/ATP1A1/ATP2B4/PLCB4/GNAQ/ITPR3/ATP2B1/ADCY4/NOS1/PLCB1/VAMP2/SLC12A2/ITPR1/PLCB3/KCNMA1/PRKG1/SLC9A1/ADCY6	-1.09861576383332
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/2270	31/9376	0.666192979963052	ALDH2/UGDH/ALDH3A2/HSD17B14/UGT2B7	-1.05213780318401
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	5/2270	31/9376	0.666192979963052	SRPRA/SEC63/IMMP2L/SEC62/SRP14	-1.05213780318401
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/2270	26/9376	0.635445611657065	PLA2G4A/PLA2G12A/ACOX3/ACOX1	-1.05203251868165
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/2270	52/9376	0.714876313114199	INSR/LDLR/PTGS2/BMP6/AKR1C3/PLA2G4A/ADCY4/HSD17B7/ADCY6	-1.16525185452272
NA	NA	hsa03272	Virion - Hepatitis viruses	8/2270	48/9376	0.688399412628487	HSPG2/LDLR/EGFR/CHMP4B/IST1/TSG101/CLDN15/CLDN14	-1.22323692642479
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/2270	43/9376	0.672390123962709	PLPP3/SLC27A4/PLPP1/PLA2G12A/APOB/DGAT1/APOA1	-1.21693265624925
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/2270	28/9376	0.590056639395846	SLC12A7/ATP6V1E1/ATP6V1D/ATP6V0A2	-1.22780524998449
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	18/2270	99/9376	0.750981177412895	HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQB1/CFI/HLA-DMA/HLA-DRA/CFH/HLA-DQA2/HLA-DQA1/SELP/HLA-DOA/C1S/ICAM1/CFB/C3/HLA-DQB2	-1.40777082190197
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	48/2270	238/9376	0.833021137970607	VWF/PIK3R3/IKBKB/PIK3CB/CSF3/STAT3/STAT1/TNFRSF1A/TBK1/JAK1/ADAM17/MX1/EGFR/RELA/SELP/ADAR/MAPK3/IFIH1/CGAS/IL6/IL6R/STAT2/IRF3/NFKBIA/NFKBIB/C1S/OAS2/PLCG2/CFB/HBEGF/MAPK11/IRAK4/EIF2AK2/MAPK12/MAPK8/RPS26/MAPK1/IFNAR2/C3/IFNAR1/OAS3/MX2/TRAF6/PLCG1/OAS1/ACE/TLR3/PIK3CA	-1.47472269523986
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/2270	23/9376	0.538747366404903	LNPEP/ACE/REN	-1.25173753380057
Organismal Systems	Digestive system	hsa04976	Bile secretion	16/2270	90/9376	0.73429270680372	ABCB1/ATP1A1/AQP1/LDLR/EPHX1/ABCG2/ABCC4/ADCY4/ABCB4/ABCC3/HMGCR/NCEH1/SLC4A5/SLC9A1/ADCY6/UGT2B7	-1.43151649109131
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/2270	76/9376	0.706515186645027	ATP1A1/PLCB4/GNAQ/ITPR3/ADCY4/PLCB1/GNAI3/CAMK2D/KCNJ2/ITPR1/PLCB3/SLC9A1/ADCY6	-1.45190071887201
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	6/2270	41/9376	0.604448264746965	MAOB/MAOA/AOC3/GCAT/DMGDH/CTH	-1.43457753783095
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	14/2270	82/9376	0.705189642204792	UPP1/DPYD/UCK2/CDA/NME7/NME1/HPRT1/CMPK1/GSTM3/MGST1/CDADC1/GSTT2B/GSTO2/UGT2B7	-1.51542446840274
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/2270	87/9376	0.71213732340878	ATP1A1/ASPH/COX7A1/CACNB2/TPM4/TPM2/ATP2A2/CACNA1C/CACNA2D1/TPM3/SLC9A7/SLC9A6/TPM1/SLC9A1/ATP2A3	-1.52456683951279
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	66/2270	323/9376	0.843981942417588	THBS1/ABCB1/SLC7A1/CDKN1A/HOXD10/PIK3R3/TNC/FOXP1/SHC1/TNXB/IKBKB/PTGS2/MCL1/PIK3CB/BMPR2/VEGFA/STAT3/ITGA5/ITGB3/SOX4/HDAC4/MET/PRKCE/ZEB1/EGFR/GLS/MYC/E2F3/RDX/ABL1/DDIT4/MAPK3/MAP2K1/RPTOR/TIMP3/NOTCH1/MTOR/PLCG2/NOTCH4/EZH2/DNMT1/HDAC1/MAPK1/ROCK1/SOS2/BCL2/PDGFA/CREBBP/PLCG1/ABCC1/MDM2/RASSF1/CRK/HMOX1/EP300/TGFB2/HDAC5/IRS2/ERBB2/BCL2L11/PDGFB/PIK3CA/TPM1/MAPK7/SPRY2/BRCA1	-1.61274547803564
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/2270	36/9376	0.573666177190406	FGGY/UGDH/UGP2/XYLB/UGT2B7	-1.44848354483039
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	11/2270	68/9376	0.668152371080591	DHRS3/ALDH1A2/ALDH1A3/RDH11/ALDH1A1/RDH10/DGAT1/RETSAT/DHRS4/RDH13/UGT2B7	-1.55221170185125
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	60/2270	298/9376	0.831623451497502	CCL14/TGFBR2/RELL1/CCL21/ACKR3/LEPR/OSMR/IL4R/IL15/IL3RA/TNFRSF11B/CD40/BMPR2/INHBB/CSF3/IL33/GHR/TNFRSF10B/IL1R1/BMP6/TNFRSF10D/TNFRSF10A/CX3CL1/TNFRSF1A/IL15RA/CCL23/CLCF1/BMP2/IL1RL1/CXCL2/ACVR1B/IL6/IL6R/TNFRSF10C/TNFSF9/ACKR4/IL17RA/TSLP/IFNAR2/IL34/IFNAR1/IL13RA1/IL18R1/CCL16/IL1RAP/TNFRSF12A/CXCL1/GDF7/IL7/CXCL3/IL7R/INHBA/GDF3/TGFB2/IL11RA/TNFRSF6B/CXCR4/CCL15/BMP4/IFNG	-1.66947765583514
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/2270	31/9376	0.532954383970442	ACO1/PCCA/CS/ACSS2	-1.47209710683039
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	5/2270	37/9376	0.55816168591499	MAOB/MAOA/AOC3/GOT1/LRTOMT	-1.52194869520249
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	15/2270	89/9376	0.696134237489482	GNG12/GABBR1/GABARAPL1/GNB5/GLS/SLC38A1/GPHN/ADCY4/GABRE/GNAI3/CACNA1C/GNB1/GNB4/ADCY6/GNAO1	-1.62788984995506
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	53/2270	268/9376	0.816832138865146	RYR3/TUBB6/SLC39A14/MCU/COX7A1/MAOB/MAOA/PINK1/UBE2G2/DDIT3/KLC1/ITPR3/LRRK2/UBC/TXN/UBE2G1/TUBB4B/MT-ATP8/PRKN/ERN1/UBE2L6/PSMD11/NFE2L2/SNCA/EIF2S1/GNAI3/PSMD14/GNAL/CAMK2D/ATF6/NDUFV1/SLC39A11/MAPK8/PSMD13/UBE2J1/TUBA1C/UBA1/SLC39A9/PSMC6/SDHA/ATF4/ITPR1/PLCG1/MFN2/DAXX/SLC39A8/MFN1/SLC39A7/CASP9/KLC4/TUBB3/TUBA4A/KLC2	-1.71945623158133
Genetic Information Processing	Transcription	hsa03040	Spliceosome	47/2270	243/9376	0.798883268976269	SRSF4/HSPA1B/HNRNPU/SF1/PRPF18/SF3B3/DDX23/DDX39B/CTNNBL1/PRPF3/RBMX/SNRNP70/DHX15/CWC25/CASC3/EFTUD2/SNW1/HSPA1A/SNRPA/ACIN1/FUS/DDX5/PRPF8/RBM25/RBM8A/SF3B2/DDX42/DHX8/ISY1/SF3A1/HNRNPM/TRA2A/CCDC12/PRPF40B/SNRNP40/SF3A2/SLU7/HSPA6/SNRPA1/XAB2/HSPA8/USP39/THOC1/THOC5/RBMXL1/DHX16/GPKOW	-1.79527331066591
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/2270	51/9376	0.566917163341107	TJP2/PLCG2/ATP6V1E1/SLC12A2/ATP6V1D/PLCG1/ATP6V0A2	-1.7527404348697
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	6/2270	46/9376	0.538747366404903	HEPH/FXN/HMOX1/MMAB/PPOX/UGT2B7	-1.77240480213779
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/2270	149/9376	0.720740324631168	GNG12/PLCB4/PTGS2/GNB5/GNAQ/MGLL/ITPR3/ADCY4/MAPK3/DAGLB/GABRE/CNR1/PLCB1/GNAI3/CACNA1C/NDUFV1/MAPK11/MAPK12/MAPK8/MAPK1/GNB1/ITPR1/GNB4/PLCB3/ADCY6/GNAO1	-1.9420350684532
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	44/2270	235/9376	0.773350829506046	CREB5/ACSL4/PRKAG2/ACSL5/COX7A1/RPS6KA2/ZNF516/RPS6KA3/FGFR1/CPT1A/PNPLA2/NPR1/MGLL/ADCY4/MT-ATP8/CNR1/NDUFAF2/SLC25A29/RPS6KB1/RPTOR/SMARCC1/SMARCA2/MTOR/SMARCA4/PRKAA1/SMARCC2/ARID1B/CREB3L2/NDUFV1/MAP2K3/MAPK11/ATF2/MAPK12/SOS2/SDHA/NDUFAF7/KDM1A/KDM3A/KDM3B/PRKAA2/PRKG1/COX19/ADCY6/AKT1S1	-1.98873618516683
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/2270	26/9376	0.317722805828533	NR5A2/HES1	-1.96891826837111
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	50/2270	275/9376	0.750981177412895	RYR3/TUBB6/CREB5/PIK3R3/PIK3CB/MCU/PPP3CA/STIP1/COX7A1/HSPA1B/DDIT3/KLC1/PPP3CC/ITPR3/TUBB4B/MAPK3/MT-ATP8/IL6/PSMD11/EIF2S1/PSMD14/NOTCH1/CACNA1C/HSPA1A/CREB3L2/NDUFV1/MAPK11/ATF2/MAPK12/ATF6B/MAPK8/PSMD13/PPP3CB/MAPK1/TUBA1C/GSK3B/PSMC6/SDHA/ATF4/ITPR1/HSPA6/HSPA8/FYN/CASP9/KLC4/TUBB3/PPP3R1/PIK3CA/TUBA4A/KLC2	-2.3688629219691
Human Diseases	Substance dependence	hsa05034	Alcoholism	32/2270	191/9376	0.692003598034919	GNG12/CREB5/SHC1/MAOB/GNB5/HDAC4/MAOA/HDAC7/CAMKK2/FOSB/MAPK3/MAP2K1/SLC29A1/GNAI3/BRAF/CREB3L2/HDAC1/ATF2/ATF6B/MAPK1/GNB1/SOS2/ATF4/GNB4/PPP1CB/ARAF/CAMKK1/HDAC5/HDAC3/HDAC6/HDAC10/GNAO1	-2.43057323705946
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8/2270	66/9376	0.500654118275264	AKR1C3/CYP7B1/HSD17B12/HSD17B7/SULT1E1/LRTOMT/DHRS11/UGT2B7	-2.30083017772223
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9/2270	73/9376	0.509226962766278	MAOB/MAOA/GSTM3/FMO2/MGST1/GSTT2B/GSTO2/FMO4/UGT2B7	-2.37912126956966
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/2270	29/9376	0.284854929363512	GNB1/SLC24A1	-2.179932229418
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	34/2270	205/9376	0.685041366713227	INSR/TGFBR2/AKT3/PIK3R3/SMAD3/PLCB4/NOS3/PIK3CB/COX7A1/RELA/SP1/MT-ATP8/PLCB1/SMAD2/ATP2A2/GYS1/MTOR/CAMK2D/NDUFV1/MAPK11/MAPK12/MAPK8/GSK3B/SDHA/PLCB3/AKT2/PPP1CB/GFPT2/TGFB2/ACE/PIK3CA/GAPDH/ATP2A3/REN	-2.5769623072873
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/2270	30/9376	0.275359765051395	PLA2G4A/PLA2G12A	-2.24675723244557
Organismal Systems	Sensory system	hsa04742	Taste transduction	10/2270	86/9376	0.480278659973363	GABBR1/PLCB4/ITPR3/ADCY4/PLCB1/CACNA1C/PLCB3/HTR1F/SCNN1B/ADCY6	-2.73651531727117
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/2270	70/9376	0.413039647577092	EPHX1/PTGS2/GSTM3/MGST1/GSTT2B/GSTO2/UGT2B7	-2.78587886087736
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	27/2270	183/9376	0.6094027587203	FBL/HEATR1/NOP58/NXT1/XRN2/GTPBP4/MDN1/RIOK1/FCF1/LSG1/WDR43/WDR75/GNL3L/GNL2/UTP4/POP5/BMS1/GNL3/NXF1/EFL1/NAT10/UTP6/REXO5/NOB1/XRN1/RCL1/RMRP	-3.0158660725751
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	29/2270	195/9376	0.614264091268497	VWF/AKT3/PIK3R3/PLCB4/PIK3CB/ITGB3/CASP4/HDAC4/HDAC7/RELA/SELP/MAPK3/MAP2K1/PLCB1/MTOR/PLCG2/HDAC1/MAPK11/MAPK12/MAPK1/C3/PLCG1/PLCB3/AKT2/HDAC5/HDAC3/HDAC6/HDAC10/PIK3CA	-3.07643927490752
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/2270	103/9376	0.481211239895642	COL8A1/ATP1A1/COL18A1/SLC1A1/COL21A1/SLC3A2/SLC1A5/SLC36A4/COL27A1/COL12A1/COL6A3/COL13A1	-2.99216133003916
NA	NA	hsa04382	Cornified envelope formation	33/2270	217/9376	0.62812480967945	LAMA3/ITGB4/PPP2R1B/ITGA6/PLEC/KAZN/PPP2R3A/UGCG/PPP2R5A/PPP2R5C/S100A13/PPP2R5E/KDSR/SLC27A4/S100A16/SPTLC1/GBA2/ELOVL1/PPP2R2D/JUP/EPHX2/S100A3/DSP/LAMA5/PPP2R5B/TCHH/BLMH/S100A10/PPL/SPTLC3/CLDN15/LAMB3/CLDN14	-3.13248505723119
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	19/2270	143/9376	0.548793937340193	ACTN1/HLA-DRB1/HLA-DRB5/HLA-DPA1/HLA-DPB1/HLA-DQB1/HLA-DMA/HLA-DRA/CD40/HLA-DQA2/HLA-DQA1/HLA-DOA/C1S/RO60/C3/ACTN4/TRIM21/HLA-DQB2/IFNG	-3.07296414235342
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7/2270	79/9376	0.36598449785312	EPHX1/CBR3/GSTM3/MGST1/GSTT2B/GSTO2/UGT2B7	-3.19836461661655
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/2270	41/9376	0.100741377457827	GABRE	-3.26140958470211
NA	NA	hsa04082	Neuroactive ligand signaling	21/2270	199/9376	0.435870984880349	GNG12/GABBR1/PLCB4/GNB5/SLC1A1/GNAQ/ADCY4/HRH1/GABRE/PLCB1/GNAI3/GNAL/GNA11/GNB1/TACR1/GNB4/PLCB3/HTR1F/ADRA2C/ADCY6/GNAO1	-4.5461166493911
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	8/2270	138/9376	0.239443273957735	COX7A1/MT-ATP8/NDUFV1/ATP6V1E1/ATP6V1D/SDHA/ATP6V0A2/LHPP	-5.08707500328779
Genetic Information Processing	Translation	hsa03010	Ribosome	5/2270	222/9376	0.0930269476524983	MRPL18/DAP3/RPS26/MRPL45/MRPS2	-7.72949965356989
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	28/2270	370/9376	0.312570544112394	CALCRL/GABBR1/LEPR/BDKRB2/RXFP1/GHR/LYPD6B/OXTR/HRH1/ADM/GABRE/CNR1/CHRNA5/THRB/S1PR1/EDN1/PTGER3/C3/AVPR2/TACR1/NTS/F2RL3/HTR1F/BDKRB1/MC1R/GZMA/ADRA2C/NMUR2	-7.62516056846237
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/2270	449/9376	0.0643937089763841	ANO2/PDE2A/GNAL/CAMK2D/GNB1/ARRB1/PRKG1	-11.482844976089