ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 236/4869 495/18639 0.476767676767677 1.82511249276499 1.56813628872457e-25 2.10914330833455e-22 GO:0106310 protein serine kinase activity 162/4869 361/18639 0.448753462603878 1.71787138826734 6.64444971318821e-15 4.46839243211907e-12 GO:0141003 histone H2AX kinase activity 155/4869 354/18639 0.437853107344633 1.67614378061134 3.10315847065755e-13 1.39124938101147e-10 GO:0003713 transcription coactivator activity 120/4869 256/18639 0.46875 1.79442005545287 5.60592124115635e-13 1.39800361219125e-10 GO:0140297 DNA-binding transcription factor binding 199/4869 488/18639 0.407786885245902 1.56104739250326 6.55342662625816e-13 1.39800361219125e-10 GO:0140996 histone H3 kinase activity 155/4869 357/18639 0.434173669467787 1.66205853875746 7.13296549124242e-13 1.39800361219125e-10 GO:0035173 histone kinase activity 156/4869 360/18639 0.433333333333333 1.65884165126309 7.27585523073513e-13 1.39800361219125e-10 GO:0004674 protein serine/threonine kinase activity 180/4869 433/18639 0.415704387990762 1.59135635402748 1.15110964169641e-12 1.93530308510208e-10 GO:0001221 transcription coregulator binding 65/4869 115/18639 0.565217391304348 2.16370650164751 4.55404188824458e-12 6.8057625996544e-10 GO:0044389 ubiquitin-like protein ligase binding 140/4869 322/18639 0.434782608695652 1.66438961665193 8.13066606426561e-12 1.09357458564372e-09 GO:0031625 ubiquitin protein ligase binding 133/4869 302/18639 0.440397350993377 1.68588338984711 9.03865845255441e-12 1.10518141988052e-09 GO:0003714 transcription corepressor activity 98/4869 204/18639 0.480392156862745 1.83898735094777 1.2608159266025e-11 1.41316451773363e-09 GO:0140857 histone H3T45 kinase activity 112/4869 246/18639 0.455284552845528 1.74287302946967 3.25714659807514e-11 2.42457467818599e-09 GO:0045296 cadherin binding 142/4869 334/18639 0.425149700598802 1.62751391855845 4.15243388585271e-11 2.42457467818599e-09 GO:0035402 histone H3T11 kinase activity 112/4869 247/18639 0.453441295546559 1.73581686335845 4.44095622945414e-11 2.42457467818599e-09 GO:0004676 3-phosphoinositide-dependent protein kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0004711 ribosomal protein S6 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0035175 histone H3S10 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0035979 histone H2AXS139 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0044022 histone H3S28 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0044023 histone H4S1 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0044024 histone H2AS1 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0044025 histone H2BS14 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0072354 histone H3T3 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0072371 histone H2AS121 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0072518 Rho-dependent protein serine/threonine kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0140823 histone H2BS36 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0140855 histone H3S57 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0140995 histone H2A kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0140997 histone H4 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0140998 histone H2B kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:1990244 histone H2AT120 kinase activity 111/4869 245/18639 0.453061224489796 1.73436191482138 5.76850481055404e-11 2.42457467818599e-09 GO:0004679 AMP-activated protein kinase activity 112/4869 248/18639 0.451612903225806 1.72881760181265 6.03487468024784e-11 2.45966861967677e-09 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 110/4869 243/18639 0.452674897119342 1.73288301651415 7.49171481784121e-11 2.9636342441166e-09 GO:0004677 DNA-dependent protein kinase activity 111/4869 246/18639 0.451219512195122 1.72731166313512 7.83339934081472e-11 3.01026346097023e-09 GO:0035403 histone H3T6 kinase activity 111/4869 247/18639 0.449392712550607 1.72031849850704 1.06022315861162e-10 3.96111152314618e-09 GO:0019902 phosphatase binding 90/4869 190/18639 0.473684210526316 1.81330868761553 2.17588401317221e-10 7.90963242626114e-09 GO:0003779 actin binding 171/4869 443/18639 0.386004514672686 1.47766238426457 4.03219745533141e-09 1.42718567826862e-07 GO:0016887 ATP hydrolysis activity 162/4869 417/18639 0.388489208633094 1.48717403156957 6.1011980667562e-09 2.10413112815054e-07 GO:0060589 nucleoside-triphosphatase regulator activity 185/4869 490/18639 0.377551020408163 1.44530159568448 6.88865801032139e-09 2.31631125597057e-07 GO:0001222 transcription corepressor binding 32/4869 49/18639 0.653061224489796 2.49998113848127 9.68201723030911e-09 3.17617394506482e-07 GO:0030695 GTPase regulator activity 184/4869 489/18639 0.376278118609407 1.44042880524969 1.01472997721429e-08 3.21012133005866e-07 GO:0003725 double-stranded RNA binding 43/4869 75/18639 0.573333333333333 2.19477510782502 1.02628414269533e-08 3.21012133005866e-07 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 139/4869 349/18639 0.398280802292264 1.5246571932482 1.18396319826311e-08 3.61916023105427e-07 GO:0019903 protein phosphatase binding 69/4869 144/18639 0.479166666666667 1.83429605668515 1.48580671832623e-08 4.44091119144173e-07 GO:0031267 small GTPase binding 116/4869 283/18639 0.409893992932862 1.56911360326055 2.9707688647523e-08 8.68626983280836e-07 GO:0004842 ubiquitin-protein transferase activity 169/4869 449/18639 0.376391982182628 1.44086468595235 3.92835786866188e-08 1.12417900709579e-06 GO:0019787 ubiquitin-like protein transferase activity 177/4869 479/18639 0.369519832985386 1.41455743828602 8.46019169493317e-08 2.37061621451773e-06 GO:0004386 helicase activity 71/4869 155/18639 0.458064516129032 1.75351499612426 9.1788329027425e-08 2.51949597024258e-06 GO:0051020 GTPase binding 124/4869 315/18639 0.393650793650794 1.5069330751401 1.53744853154924e-07 4.13573654986745e-06 GO:0140658 ATP-dependent chromatin remodeler activity 71/4869 158/18639 0.449367088607595 1.72022040759026 2.32201958953607e-07 6.12375754495298e-06 GO:0002039 p53 binding 38/4869 69/18639 0.550724637681159 2.10822684775911 3.06458884407079e-07 7.9266769139908e-06 GO:0016755 aminoacyltransferase activity 179/4869 496/18639 0.360887096774194 1.38151049430565 4.54829046970949e-07 1.15423597769043e-05 GO:0000510 H3-H4 histone complex chaperone activity 67/4869 151/18639 0.443708609271523 1.69855920480836 8.82082091594616e-07 2.08140423367501e-05 GO:0140584 chromatin extrusion motor activity 67/4869 151/18639 0.443708609271523 1.69855920480836 8.82082091594616e-07 2.08140423367501e-05 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 67/4869 151/18639 0.443708609271523 1.69855920480836 8.82082091594616e-07 2.08140423367501e-05 GO:0140849 ATP-dependent H2AZ histone chaperone activity 67/4869 151/18639 0.443708609271523 1.69855920480836 8.82082091594616e-07 2.08140423367501e-05 GO:0070063 RNA polymerase binding 33/4869 59/18639 0.559322033898305 2.14113850684545 1.13646243077844e-06 2.63541718861552e-05 GO:0015616 DNA translocase activity 67/4869 152/18639 0.440789473684211 1.68738447319778 1.17787416844657e-06 2.64040126093439e-05 GO:0140674 ATP-dependent histone chaperone activity 67/4869 152/18639 0.440789473684211 1.68738447319778 1.17787416844657e-06 2.64040126093439e-05 GO:0061775 cohesin loader activity 67/4869 153/18639 0.437908496732026 1.67635581651021 1.56487333876315e-06 3.45041744366629e-05 GO:0008094 ATP-dependent activity, acting on DNA 86/4869 210/18639 0.40952380952381 1.5676965055893 1.81258648845378e-06 3.93214326930698e-05 GO:0001098 basal transcription machinery binding 33/4869 60/18639 0.55 2.1054528650647 1.89372958210117e-06 3.97979107488449e-05 GO:0001099 basal RNA polymerase II transcription machinery binding 33/4869 60/18639 0.55 2.1054528650647 1.89372958210117e-06 3.97979107488449e-05 GO:0048156 tau protein binding 26/4869 43/18639 0.604651162790698 2.31466276920432 2.11429708756312e-06 4.37496858888061e-05 GO:0003689 DNA clamp loader activity 69/4869 160/18639 0.43125 1.65086645101664 2.15260509421594e-06 4.38674826018248e-05 GO:0016922 nuclear receptor binding 61/4869 137/18639 0.445255474452555 1.7044807534034 2.32031166620859e-06 4.65793909112023e-05 GO:0140097 catalytic activity, acting on DNA 126/4869 336/18639 0.375 1.43553604436229 2.52285600464317e-06 4.9900607738898e-05 GO:0005085 guanyl-nucleotide exchange factor activity 92/4869 230/18639 0.4 1.53123844731978 2.6720881593927e-06 5.20863561504809e-05 GO:0003724 RNA helicase activity 39/4869 77/18639 0.506493506493506 1.93890582615167 3.56707373219441e-06 6.85387738543069e-05 GO:0001223 transcription coactivator binding 26/4869 44/18639 0.590909090909091 2.26205679717695 3.88441666673254e-06 7.35850762923276e-05 GO:0061659 ubiquitin-like protein ligase activity 136/4869 372/18639 0.365591397849462 1.3995190109912 4.91640066949125e-06 9.18410958398019e-05 GO:0061630 ubiquitin protein ligase activity 130/4869 353/18639 0.368271954674221 1.40978044016693 5.1682427161153e-06 9.52231020982887e-05 GO:0140597 protein carrier chaperone 77/4869 188/18639 0.409574468085106 1.56789043143116 6.0955035189347e-06 0.000110789895040097 GO:0071889 14-3-3 protein binding 21/4869 33/18639 0.636363636363636 2.43606116619056 6.46955697239894e-06 0.000116020721705021 GO:0008186 ATP-dependent activity, acting on RNA 39/4869 79/18639 0.493670886075949 1.88981960270479 7.90892283817922e-06 0.000139967121280935 GO:0140713 histone chaperone activity 68/4869 164/18639 0.414634146341463 1.58725936612416 1.27835695513547e-05 0.000223297416189248 GO:0032182 ubiquitin-like protein binding 53/4869 120/18639 0.441666666666667 1.69074245224892 1.37804138199663e-05 0.000237623802408393 GO:0016791 phosphatase activity 103/4869 273/18639 0.377289377289377 1.44430000067708 1.4843039918681e-05 0.000252707451780076 GO:0043175 RNA polymerase core enzyme binding 24/4869 42/18639 0.571428571428571 2.18748349617111 2.01237719715818e-05 0.00033833091627222 GO:0051219 phosphoprotein binding 43/4869 93/18639 0.462365591397849 1.76997992566533 2.24443313935285e-05 0.000372686737336985 GO:0042393 histone binding 94/4869 247/18639 0.380566801619433 1.45684629603299 2.31590506260222e-05 0.000379864915756095 GO:0140098 catalytic activity, acting on RNA 137/4869 387/18639 0.354005167958656 1.35516580932048 2.91166086060883e-05 0.00047182938042396 GO:0035591 signaling adaptor activity 55/4869 129/18639 0.426356589147287 1.63213400392612 3.28105154948296e-05 0.000525358849292213 GO:0045309 protein phosphorylated amino acid binding 30/4869 59/18639 0.508474576271186 1.94648955167768 4.21557926567821e-05 0.000667053424980846 GO:0050321 tau-protein kinase activity 15/4869 22/18639 0.681818181818182 2.61006553520417 4.28793400103904e-05 0.000670612933883432 GO:0000993 RNA polymerase II complex binding 21/4869 36/18639 0.583333333333333 2.23305606900801 4.34996477931818e-05 0.000672494554963557 GO:0001046 core promoter sequence-specific DNA binding 24/4869 44/18639 0.545454545454545 2.08805242816333 5.68090730092262e-05 0.000868275036334196 GO:0140104 molecular carrier activity 93/4869 249/18639 0.373493975903614 1.42977083936485 5.85601337446858e-05 0.000884981796478679 GO:0051721 protein phosphatase 2A binding 18/4869 30/18639 0.6 2.29685767097967 9.22751586727915e-05 0.00137551138922345 GO:0005096 GTPase activator activity 99/4869 271/18639 0.365313653136531 1.39845577753375 9.30643393452296e-05 0.00137551138922345 GO:0140693 molecular condensate scaffold activity 25/4869 48/18639 0.520833333333333 1.99380006161429 0.000109509466784335 0.00160098079157533 GO:0031490 chromatin DNA binding 53/4869 128/18639 0.4140625 1.58507104898336 0.000114776807849145 0.00165994415652796 GO:0004721 phosphoprotein phosphatase activity 68/4869 175/18639 0.388571428571429 1.48748877739636 0.000143601540465938 0.00205472416943284 GO:0042578 phosphoric ester hydrolase activity 126/4869 363/18639 0.347107438016529 1.32876063610394 0.000157832148658111 0.00223457094679115 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 97/4869 268/18639 0.361940298507463 1.38554225177256 0.000161190515173241 0.00225834628029176 GO:0005484 SNAP receptor activity 20/4869 36/18639 0.555555555555556 2.12672006572191 0.000167735830377032 0.00230283148646859 GO:0001217 DNA-binding transcription repressor activity 100/4869 278/18639 0.359712230215827 1.37701299219405 0.00016778995217392 0.00230283148646859 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 29/4869 60/18639 0.483333333333333 1.85024645717807 0.000179846637843939 0.0024183562099093 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 9/4869 11/18639 0.818181818181818 3.132078642245 0.000181601470037798 0.0024183562099093 GO:0043522 leucine zipper domain binding 9/4869 11/18639 0.818181818181818 3.132078642245 0.000181601470037798 0.0024183562099093 GO:0005525 GTP binding 130/4869 378/18639 0.343915343915344 1.31654099306595 0.000196934668951683 0.00259683460529425 GO:0043021 ribonucleoprotein complex binding 68/4869 177/18639 0.384180790960452 1.47068099460092 0.000212434028741559 0.00276804806445029 GO:0050660 flavin adenine dinucleotide binding 38/4869 86/18639 0.441860465116279 1.69148433134162 0.00021403494327348 0.00276804806445029 GO:0004713 protein tyrosine kinase activity 56/4869 140/18639 0.4 1.53123844731978 0.000223112454150411 0.00285796429364098 GO:0042605 peptide antigen binding 23/4869 45/18639 0.511111111111111 1.95658246046416 0.000294183622034453 0.00373280161921075 GO:0032451 demethylase activity 21/4869 40/18639 0.525 2.00975046210721 0.000332781895969332 0.00418309953344628 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 15/4869 25/18639 0.6 2.29685767097967 0.000358438198274363 0.00446388311739832 GO:0032452 histone demethylase activity 17/4869 30/18639 0.566666666666667 2.16925446703635 0.000376581280586552 0.00464680570999003 GO:0017124 SH3 domain binding 47/4869 115/18639 0.408695652173913 1.56452623965282 0.000388017898193716 0.0047444006642777 GO:0051015 actin filament binding 77/4869 209/18639 0.368421052631579 1.41035120147874 0.000392745918589102 0.0047589482928139 GO:1990841 promoter-specific chromatin binding 31/4869 68/18639 0.455882352941176 1.74516146569534 0.000408198017097363 0.00490202083032101 GO:0015631 tubulin binding 130/4869 385/18639 0.337662337662338 1.29260388410111 0.000465702381502495 0.00554309471788368 GO:0141052 histone H3 demethylase activity 16/4869 28/18639 0.571428571428571 2.18748349617111 0.000492420616774364 0.0058096993821186 GO:0019888 protein phosphatase regulator activity 44/4869 107/18639 0.411214953271028 1.57417036640351 0.000500745632949085 0.00585654675057843 GO:0000287 magnesium ion binding 83/4869 230/18639 0.360869565217391 1.3814433818211 0.000510463241844134 0.00591873327827897 GO:0019001 guanyl nucleotide binding 134/4869 400/18639 0.335 1.28241219963031 0.000555104242917056 0.00632724751460542 GO:0032561 guanyl ribonucleotide binding 134/4869 400/18639 0.335 1.28241219963031 0.000555104242917056 0.00632724751460542 GO:0032395 MHC class II receptor activity 8/4869 10/18639 0.8 3.06247689463956 0.000573859829161522 0.00643201225185206 GO:0099122 RNA polymerase II C-terminal domain binding 8/4869 10/18639 0.8 3.06247689463956 0.000573859829161522 0.00643201225185206 GO:0140457 protein demethylase activity 17/4869 31/18639 0.548387096774194 2.09927851648679 0.00063179722228085 0.00702286995014664 GO:0001784 phosphotyrosine residue binding 23/4869 47/18639 0.48936170212766 1.8733236323593 0.000656054727985495 0.00723273450115157 GO:0005520 insulin-like growth factor binding 12/4869 19/18639 0.631578947368421 2.4177449168207 0.000742624243320033 0.00812056591272719 GO:0140296 general transcription initiation factor binding 25/4869 53/18639 0.471698113207547 1.80570571617898 0.000777460274528416 0.00843293604226387 GO:0032183 SUMO binding 11/4869 17/18639 0.647058823529412 2.47700337066435 0.000930871826729308 0.00993668735675333 GO:0038191 neuropilin binding 11/4869 17/18639 0.647058823529412 2.47700337066435 0.000930871826729308 0.00993668735675333 GO:0004532 RNA exonuclease activity 20/4869 40/18639 0.5 1.91404805914972 0.00103292649007976 0.0109392608595061 GO:0004725 protein tyrosine phosphatase activity 40/4869 98/18639 0.408163265306122 1.56248821155079 0.00104637800049837 0.0109951438333617 GO:0023026 MHC class II protein complex binding 15/4869 27/18639 0.555555555555556 2.12672006572191 0.00109919495141313 0.0114605985244238 GO:0051371 muscle alpha-actinin binding 10/4869 15/18639 0.666666666666667 2.5520640788663 0.00114980098080817 0.0118960178399 GO:0019208 phosphatase regulator activity 46/4869 117/18639 0.393162393162393 1.50506343112628 0.00119217436204031 0.0122402634881238 GO:0010485 histone H4 acetyltransferase activity 18/4869 35/18639 0.514285714285714 1.968735146554 0.00120243091783778 0.0122520423067562 GO:0016779 nucleotidyltransferase activity 52/4869 136/18639 0.382352941176471 1.46368380993802 0.00125519481490975 0.0125987837765195 GO:0140789 histone phosphatase activity 52/4869 136/18639 0.382352941176471 1.46368380993802 0.00125519481490975 0.0125987837765195 GO:0043995 histone H4K5 acetyltransferase activity 16/4869 30/18639 0.533333333333333 2.04165126309304 0.00135521582808073 0.0133048561223984 GO:0043996 histone H4K8 acetyltransferase activity 16/4869 30/18639 0.533333333333333 2.04165126309304 0.00135521582808073 0.0133048561223984 GO:0043997 histone H4K12 acetyltransferase activity 16/4869 30/18639 0.533333333333333 2.04165126309304 0.00135521582808073 0.0133048561223984 GO:0031994 insulin-like growth factor I binding 9/4869 13/18639 0.692307692307692 2.65022038959192 0.00138910914279696 0.0134413798349778 GO:0140852 histone ubiquitin ligase activity 9/4869 13/18639 0.692307692307692 2.65022038959192 0.00138910914279696 0.0134413798349778 GO:0015095 magnesium ion transmembrane transporter activity 12/4869 20/18639 0.6 2.29685767097967 0.00141617264692087 0.0136053729293469 GO:0035401 histone H3Y41 kinase activity 45/4869 115/18639 0.391304347826087 1.49795065498674 0.0014997450159367 0.0142053313129215 GO:0140801 histone H2AXY142 kinase activity 45/4869 115/18639 0.391304347826087 1.49795065498674 0.0014997450159367 0.0142053313129215 GO:0140416 transcription regulator inhibitor activity 17/4869 33/18639 0.515151515151515 1.97204951548759 0.00159819382205472 0.0150319628717734 GO:0008526 phosphatidylinositol transfer activity 8/4869 11/18639 0.727272727272727 2.78406990421778 0.00161988212015812 0.0151301489695324 GO:0043130 ubiquitin binding 40/4869 100/18639 0.4 1.53123844731978 0.00165094099809231 0.0153139009823045 GO:0140030 modification-dependent protein binding 63/4869 173/18639 0.364161849710983 1.39404656331136 0.00175140983497218 0.0160425801140958 GO:0046332 SMAD binding 33/4869 79/18639 0.417721518987342 1.59907812536559 0.00175335262213537 0.0160425801140958 GO:0061733 protein-lysine-acetyltransferase activity 22/4869 47/18639 0.468085106382979 1.79187477877846 0.00178721160735627 0.0161338953470747 GO:0036408 histone H3K14 acetyltransferase activity 15/4869 28/18639 0.535714285714286 2.05076577766042 0.00179931918368863 0.0161338953470747 GO:0051019 mitogen-activated protein kinase binding 15/4869 28/18639 0.535714285714286 2.05076577766042 0.00179931918368863 0.0161338953470747 GO:0044013 histone H2B acetyltransferase activity 13/4869 23/18639 0.565217391304348 2.16370650164751 0.00191283463222669 0.017038162783741 GO:0031593 polyubiquitin modification-dependent protein binding 26/4869 59/18639 0.440677966101695 1.68695761145399 0.00212136574569701 0.0187712955787006 GO:0140767 enzyme-substrate adaptor activity 52/4869 139/18639 0.37410071942446 1.43209351188181 0.00218605400753054 0.0192172721577031 GO:0004402 histone acetyltransferase activity 20/4869 42/18639 0.476190476190476 1.82290291347593 0.00220505491983629 0.0192584342024663 GO:0003684 damaged DNA binding 31/4869 74/18639 0.418918918918919 1.60366188739571 0.00225521191876412 0.0195694195531467 GO:0035091 phosphatidylinositol binding 96/4869 284/18639 0.338028169014085 1.29400432167869 0.0022982982874504 0.0198154563885948 GO:0030275 LRR domain binding 10/4869 16/18639 0.625 2.39256007393715 0.00234916487926401 0.0198718664315101 GO:0070411 I-SMAD binding 10/4869 16/18639 0.625 2.39256007393715 0.00234916487926401 0.0198718664315101 GO:0140328 floppase activity 10/4869 16/18639 0.625 2.39256007393715 0.00234916487926401 0.0198718664315101 GO:0050681 nuclear androgen receptor binding 14/4869 26/18639 0.538461538461538 2.06128252523816 0.00239148055803824 0.020103383441009 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 154/4869 484/18639 0.318181818181818 1.21803058309528 0.00265215296400963 0.0221561846993351 GO:0004527 exonuclease activity 34/4869 84/18639 0.404761904761905 1.54946747645454 0.00282228143823453 0.0233878497630516 GO:0010484 histone H3 acetyltransferase activity 15/4869 29/18639 0.517241379310345 1.98004971636178 0.00283436394897949 0.0233878497630516 GO:0031072 heat shock protein binding 49/4869 131/18639 0.374045801526718 1.43188328089063 0.00288833116285314 0.0235443560008854 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 79/4869 229/18639 0.344978165938865 1.32060957792863 0.00291145291313953 0.0235443560008854 GO:0061791 GTPase motor activity 19/4869 40/18639 0.475 1.81834565619224 0.00292335126553744 0.0235443560008854 GO:1990606 membrane scission GTPase motor activity 19/4869 40/18639 0.475 1.81834565619224 0.00292335126553744 0.0235443560008854 GO:0032454 histone H3K9 demethylase activity 9/4869 14/18639 0.642857142857143 2.4609189331925 0.00298823334663875 0.0239236538763638 GO:0000149 SNARE binding 41/4869 106/18639 0.386792452830189 1.48067868726677 0.00304160287550638 0.0242068394529946 GO:0001091 RNA polymerase II general transcription initiation factor binding 13/4869 24/18639 0.541666666666667 2.07355206407887 0.0031821946550387 0.0250295427545442 GO:0043998 histone H2A acetyltransferase activity 13/4869 24/18639 0.541666666666667 2.07355206407887 0.0031821946550387 0.0250295427545442 GO:0051059 NF-kappaB binding 16/4869 32/18639 0.5 1.91404805914972 0.00323201177704061 0.0252735804658117 GO:0046527 glucosyltransferase activity 11/4869 19/18639 0.578947368421053 2.21626617375231 0.00332423628017628 0.0258444959354745 GO:0005516 calmodulin binding 72/4869 207/18639 0.347826086956522 1.33151169332155 0.00343844023607515 0.0265787478018452 GO:0001216 DNA-binding transcription activator activity 155/4869 491/18639 0.315682281059063 1.20846211473811 0.00361310869979412 0.0277693211498462 GO:0017166 vinculin binding 8/4869 12/18639 0.666666666666667 2.5520640788663 0.00374580113564087 0.0284638560872145 GO:0035259 nuclear glucocorticoid receptor binding 8/4869 12/18639 0.666666666666667 2.5520640788663 0.00374580113564087 0.0284638560872145 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 18/4869 38/18639 0.473684210526316 1.81330868761553 0.00387931257202784 0.0293127831987497 GO:0001727 lipid kinase activity 19/4869 41/18639 0.463414634146341 1.77399576213877 0.00413025279621011 0.0296998570397368 GO:0032931 histone H3K56 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0043992 histone H3K9 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0043993 histone H3K18 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0043994 histone H3K23 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0043999 histone H2AK5 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0044012 histone H2AK9 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0044014 histone H2BK5 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0044015 histone H2BK12 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0044016 histone H3K4 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0044017 histone H3K27 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0044018 histone H3K36 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0046972 histone H4K16 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0140908 histone H3K122 acetyltransferase activity 12/4869 22/18639 0.545454545454545 2.08805242816333 0.00423968219452005 0.0296998570397368 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 35/4869 89/18639 0.393258426966292 1.50543105775821 0.00431774436189804 0.0299348771482107 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 35/4869 89/18639 0.393258426966292 1.50543105775821 0.00431774436189804 0.0299348771482107 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 10/4869 17/18639 0.588235294117647 2.2518212460585 0.00437529781145644 0.0300521770500762 GO:0008017 microtubule binding 92/4869 276/18639 0.333333333333333 1.27603203943315 0.00437935070766909 0.0300521770500762 GO:0042826 histone deacetylase binding 47/4869 127/18639 0.37007874015748 1.416696988662 0.00440302018095112 0.0300612291542094 GO:0003774 cytoskeletal motor activity 55/4869 153/18639 0.359477124183007 1.37611298370242 0.00451004632927222 0.0306364258225815 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 7/4869 10/18639 0.7 2.67966728280961 0.00458174737728484 0.0309670865449654 GO:0031491 nucleosome binding 30/4869 74/18639 0.405405405405405 1.55193085877005 0.00471317492110998 0.0315931742165848 GO:0034212 protein N-acetyltransferase activity 23/4869 53/18639 0.433962264150943 1.66124925888467 0.00472135912084279 0.0315931742165848 GO:0005548 phospholipid transporter activity 28/4869 68/18639 0.411764705882353 1.57627487224095 0.00480476581497796 0.0319921288175512 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 59/4869 167/18639 0.353293413173653 1.35244114359082 0.0051787389221505 0.0343123342378937 GO:0140793 histone H2AXY142 phosphatase activity 35/4869 90/18639 0.388888888888889 1.48870404600534 0.00531992175149925 0.035074974292973 GO:0016776 phosphotransferase activity, phosphate group as acceptor 18/4869 39/18639 0.461538461538462 1.76681359306128 0.00546838092188452 0.0358779138533399 GO:0019209 kinase activator activity 53/4869 148/18639 0.358108108108108 1.37087225858021 0.0057090104816717 0.0371703007732604 GO:0035198 miRNA binding 19/4869 42/18639 0.452380952380952 1.73175776780213 0.00572063365060588 0.0371703007732604 GO:0045499 chemorepellent activity 14/4869 28/18639 0.5 1.91404805914972 0.00576702631588805 0.0372915884368722 GO:0008080 N-acetyltransferase activity 28/4869 69/18639 0.405797101449275 1.55343030887514 0.00610360047554701 0.0392791513856973 GO:0005048 signal sequence binding 22/4869 51/18639 0.431372549019608 1.6513355804429 0.00616145846111798 0.0394626744295414 GO:0070325 lipoprotein particle receptor binding 15/4869 31/18639 0.483870967741935 1.8523045733707 0.00636349619076358 0.0405635183724029 GO:0030295 protein kinase activator activity 50/4869 139/18639 0.359712230215827 1.37701299219405 0.00644476048785936 0.0408877493215606 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 32/4869 82/18639 0.390243902439024 1.49389116811686 0.0070507100037096 0.0445220889905606 GO:0023023 MHC protein complex binding 17/4869 37/18639 0.459459459459459 1.75885497327272 0.00724593007045155 0.0455410090876511 GO:0043539 protein serine/threonine kinase activator activity 29/4869 73/18639 0.397260273972603 1.52075051274909 0.0075391186476734 0.0468419281999054 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 10/4869 18/18639 0.555555555555556 2.12672006572191 0.00755739659433417 0.0468419281999054 GO:0070064 proline-rich region binding 10/4869 18/18639 0.555555555555556 2.12672006572191 0.00755739659433417 0.0468419281999054 GO:0042054 histone methyltransferase activity 27/4869 67/18639 0.402985074626866 1.54266559991172 0.00780834660845952 0.0481753494879727 GO:0003727 single-stranded RNA binding 34/4869 89/18639 0.382022471910112 1.46241874182226 0.00816270621858927 0.0501316888767241 GO:0008168 methyltransferase activity 69/4869 204/18639 0.338235294117647 1.29479721648364 0.00854798211862781 0.0522592543161564 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 32/4869 83/18639 0.385542168674699 1.47589247934436 0.00865320498452595 0.0526631706071828 GO:0019887 protein kinase regulator activity 84/4869 255/18639 0.329411764705882 1.26101989779276 0.0087332159150574 0.0529107000259108 GO:0005178 integrin binding 56/4869 161/18639 0.347826086956522 1.33151169332155 0.00903072094421679 0.0544678012106349 GO:0070717 poly-purine tract binding 15/4869 32/18639 0.46875 1.79442005545287 0.0091265706734603 0.0548001676598397 GO:0016407 acetyltransferase activity 36/4869 96/18639 0.375 1.43553604436229 0.00924608785808671 0.0552710585294516 GO:0003678 DNA helicase activity 29/4869 74/18639 0.391891891891892 1.50019983014438 0.00936028238256982 0.0557061053298956 GO:0005319 lipid transporter activity 61/4869 178/18639 0.342696629213483 1.31187563604644 0.00948055117488738 0.0558891088145112 GO:0000175 3'-5'-RNA exonuclease activity 16/4869 35/18639 0.457142857142857 1.74998679693689 0.00960981676115604 0.0558891088145112 GO:0061631 ubiquitin conjugating enzyme activity 16/4869 35/18639 0.457142857142857 1.74998679693689 0.00960981676115604 0.0558891088145112 GO:0140566 histone reader activity 16/4869 35/18639 0.457142857142857 1.74998679693689 0.00960981676115604 0.0558891088145112 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 44/4869 122/18639 0.360655737704918 1.38062482955062 0.00961884677520662 0.0558891088145112 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 7/4869 11/18639 0.636363636363636 2.43606116619056 0.0097650115772566 0.0558891088145112 GO:0008432 JUN kinase binding 7/4869 11/18639 0.636363636363636 2.43606116619056 0.0097650115772566 0.0558891088145112 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 7/4869 11/18639 0.636363636363636 2.43606116619056 0.0097650115772566 0.0558891088145112 GO:0140537 transcription regulator activator activity 7/4869 11/18639 0.636363636363636 2.43606116619056 0.0097650115772566 0.0558891088145112 GO:1901981 phosphatidylinositol phosphate binding 63/4869 185/18639 0.340540540540541 1.30362192136684 0.00986435147999854 0.0559099074648129 GO:0019207 kinase regulator activity 93/4869 287/18639 0.32404181184669 1.24046320209703 0.00987723326504972 0.0559099074648129 GO:0008013 beta-catenin binding 39/4869 106/18639 0.367924528301887 1.40845045861961 0.00991192452015725 0.0559099074648129 GO:0042162 telomeric DNA binding 17/4869 38/18639 0.447368421052632 1.71256931608133 0.00997128709298495 0.0559099074648129 GO:0120013 lipid transfer activity 26/4869 65/18639 0.4 1.53123844731978 0.00997648906435323 0.0559099074648129 GO:0004707 MAP kinase activity 9/4869 16/18639 0.5625 2.15330406654344 0.0101130894875397 0.0559757422252709 GO:0034450 ubiquitin-ubiquitin ligase activity 9/4869 16/18639 0.5625 2.15330406654344 0.0101130894875397 0.0559757422252709 GO:0140327 flippase activity 9/4869 16/18639 0.5625 2.15330406654344 0.0101130894875397 0.0559757422252709 GO:0004722 protein serine/threonine phosphatase activity 38/4869 103/18639 0.368932038834951 1.41230730578038 0.0102905842706756 0.0567247370658142 GO:0030215 semaphorin receptor binding 12/4869 24/18639 0.5 1.91404805914972 0.0103739280517323 0.0569507478758368 GO:0140938 histone H3 methyltransferase activity 20/4869 47/18639 0.425531914893617 1.62897707161679 0.010483200546731 0.0573166859160701 GO:0180051 translation factor activity 32/4869 84/18639 0.380952380952381 1.45832233078074 0.010544283318375 0.0573530539202816 GO:0033192 calmodulin-dependent protein phosphatase activity 31/4869 81/18639 0.382716049382716 1.46507382305287 0.0108736273231761 0.0573530539202816 GO:0140791 histone H2AXS140 phosphatase activity 31/4869 81/18639 0.382716049382716 1.46507382305287 0.0108736273231761 0.0573530539202816 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 31/4869 81/18639 0.382716049382716 1.46507382305287 0.0108736273231761 0.0573530539202816 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 31/4869 81/18639 0.382716049382716 1.46507382305287 0.0108736273231761 0.0573530539202816 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 31/4869 81/18639 0.382716049382716 1.46507382305287 0.0108736273231761 0.0573530539202816 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 31/4869 81/18639 0.382716049382716 1.46507382305287 0.0108736273231761 0.0573530539202816 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 31/4869 81/18639 0.382716049382716 1.46507382305287 0.0108736273231761 0.0573530539202816 GO:1990439 MAP kinase serine/threonine phosphatase activity 31/4869 81/18639 0.382716049382716 1.46507382305287 0.0108736273231761 0.0573530539202816 GO:0008266 poly(U) RNA binding 13/4869 27/18639 0.481481481481481 1.84315739029233 0.011386855322327 0.059592686414513 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 13/4869 27/18639 0.481481481481481 1.84315739029233 0.011386855322327 0.059592686414513 GO:0008187 poly-pyrimidine tract binding 14/4869 30/18639 0.466666666666667 1.78644485520641 0.0121710104232366 0.0631836066410556 GO:0031624 ubiquitin conjugating enzyme binding 14/4869 30/18639 0.466666666666667 1.78644485520641 0.0121710104232366 0.0631836066410556 GO:0046624 sphingolipid transporter activity 10/4869 19/18639 0.526315789473684 2.01478743068392 0.0122609080545097 0.0631836066410556 GO:0050145 nucleoside monophosphate kinase activity 10/4869 19/18639 0.526315789473684 2.01478743068392 0.0122609080545097 0.0631836066410556 GO:0044390 ubiquitin-like protein conjugating enzyme binding 16/4869 36/18639 0.444444444444444 1.70137605257753 0.0131750511936159 0.0674922093393286 GO:0033549 MAP kinase phosphatase activity 31/4869 82/18639 0.378048780487805 1.44720706911321 0.0131973613801066 0.0674922093393286 GO:0004705 JUN kinase activity 8/4869 14/18639 0.571428571428571 2.18748349617111 0.013554208294261 0.0678242550836832 GO:0005161 platelet-derived growth factor receptor binding 8/4869 14/18639 0.571428571428571 2.18748349617111 0.013554208294261 0.0678242550836832 GO:0008174 mRNA methyltransferase activity 8/4869 14/18639 0.571428571428571 2.18748349617111 0.013554208294261 0.0678242550836832 GO:0098847 sequence-specific single stranded DNA binding 8/4869 14/18639 0.571428571428571 2.18748349617111 0.013554208294261 0.0678242550836832 GO:0019894 kinesin binding 18/4869 42/18639 0.428571428571429 1.64061262212833 0.013607706379819 0.0678242550836832 GO:0036121 double-stranded DNA helicase activity 20/4869 48/18639 0.416666666666667 1.59504004929144 0.013641826503955 0.0678242550836832 GO:0004715 non-membrane spanning protein tyrosine kinase activity 19/4869 45/18639 0.422222222222222 1.61630724994865 0.0136657049276417 0.0678242550836832 GO:0140303 intramembrane lipid transporter activity 19/4869 45/18639 0.422222222222222 1.61630724994865 0.0136657049276417 0.0678242550836832 GO:0042277 peptide binding 81/4869 249/18639 0.325301204819277 1.24528427944681 0.0137390747512458 0.0679377041927411 GO:0004407 histone deacetylase activity 11/4869 22/18639 0.5 1.91404805914972 0.0139673488887561 0.0680655226644093 GO:0016881 acid-amino acid ligase activity 11/4869 22/18639 0.5 1.91404805914972 0.0139673488887561 0.0680655226644093 GO:0033558 protein lysine deacetylase activity 11/4869 22/18639 0.5 1.91404805914972 0.0139673488887561 0.0680655226644093 GO:0070034 telomerase RNA binding 11/4869 22/18639 0.5 1.91404805914972 0.0139673488887561 0.0680655226644093 GO:0004709 MAP kinase kinase kinase activity 12/4869 25/18639 0.48 1.83748613678373 0.0152803369315048 0.0739282488232878 GO:0008139 nuclear localization sequence binding 12/4869 25/18639 0.48 1.83748613678373 0.0152803369315048 0.0739282488232878 GO:0004518 nuclease activity 69/4869 209/18639 0.330143540669856 1.26382120651991 0.0153686314477751 0.0739436982721695 GO:0008173 RNA methyltransferase activity 26/4869 67/18639 0.388059701492537 1.48552983695202 0.0153934836551728 0.0739436982721695 GO:0008135 translation factor activity, RNA binding 31/4869 83/18639 0.373493975903614 1.42977083936485 0.0159063776928567 0.0761355088857376 GO:0046966 nuclear thyroid hormone receptor binding 13/4869 28/18639 0.464285714285714 1.77733034063903 0.0162573737945741 0.07726561043711 GO:0051393 alpha-actinin binding 13/4869 28/18639 0.464285714285714 1.77733034063903 0.0162573737945741 0.07726561043711 GO:0008408 3'-5' exonuclease activity 23/4869 58/18639 0.396551724137931 1.51803811587737 0.0165949302502596 0.0783164252161375 GO:0061980 regulatory RNA binding 23/4869 58/18639 0.396551724137931 1.51803811587737 0.0165949302502596 0.0783164252161375 GO:0003924 GTPase activity 104/4869 331/18639 0.314199395770393 1.20278548732067 0.0170443370507506 0.0801560606058028 GO:0030159 signaling receptor complex adaptor activity 21/4869 52/18639 0.403846153846154 1.54596189392862 0.0172505178049335 0.0808430189813086 GO:0052866 phosphatidylinositol phosphate phosphatase activity 15/4869 34/18639 0.441176470588235 1.68886593454387 0.0174181187661573 0.0813450338211164 GO:0016763 pentosyltransferase activity 20/4869 49/18639 0.408163265306122 1.56248821155079 0.0175062848707217 0.0814738863360578 GO:0042805 actinin binding 16/4869 37/18639 0.432432432432432 1.65539291602138 0.017692476811265 0.0820439376559859 GO:0071949 FAD binding 17/4869 40/18639 0.425 1.62694085027726 0.0178117693647196 0.0820439376559859 GO:0140662 ATP-dependent protein folding chaperone 17/4869 40/18639 0.425 1.62694085027726 0.0178117693647196 0.0820439376559859 GO:0005078 MAP-kinase scaffold activity 7/4869 12/18639 0.583333333333333 2.23305606900801 0.0181919061955186 0.0826625467330152 GO:0035251 UDP-glucosyltransferase activity 7/4869 12/18639 0.583333333333333 2.23305606900801 0.0181919061955186 0.0826625467330152 GO:0043047 single-stranded telomeric DNA binding 7/4869 12/18639 0.583333333333333 2.23305606900801 0.0181919061955186 0.0826625467330152 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 7/4869 12/18639 0.583333333333333 2.23305606900801 0.0181919061955186 0.0826625467330152 GO:0031418 L-ascorbic acid binding 10/4869 20/18639 0.5 1.91404805914972 0.0188655020548642 0.0852639095965419 GO:0008234 cysteine-type peptidase activity 62/4869 187/18639 0.331550802139037 1.26920833868752 0.0188911859180442 0.0852639095965419 GO:0017018 myosin phosphatase activity 31/4869 84/18639 0.369047619047619 1.41274975794384 0.0190426970439686 0.0856602927228687 GO:0016410 N-acyltransferase activity 34/4869 94/18639 0.361702127659574 1.38463051087427 0.0200226273506363 0.0897681126220196 GO:0019783 ubiquitin-like protein peptidase activity 44/4869 127/18639 0.346456692913386 1.3262695213006 0.0203136187568731 0.0905395122824286 GO:0016741 transferase activity, transferring one-carbon groups 70/4869 215/18639 0.325581395348837 1.2463568757254 0.0203293179994747 0.0905395122824286 GO:0016757 glycosyltransferase activity 85/4869 267/18639 0.318352059925094 1.21868228485188 0.0207533337776353 0.0921228842604605 GO:0044183 protein folding chaperone 28/4869 75/18639 0.373333333333333 1.42915588416513 0.0213244597432114 0.0943467051138793 GO:0004197 cysteine-type endopeptidase activity 32/4869 88/18639 0.363636363636364 1.39203495210889 0.021743154485579 0.0946968561528392 GO:0005112 Notch binding 12/4869 26/18639 0.461538461538462 1.76681359306128 0.0217556346105779 0.0946968561528392 GO:0008157 protein phosphatase 1 binding 12/4869 26/18639 0.461538461538462 1.76681359306128 0.0217556346105779 0.0946968561528392 GO:0052742 phosphatidylinositol kinase activity 12/4869 26/18639 0.461538461538462 1.76681359306128 0.0217556346105779 0.0946968561528392 GO:0070412 R-SMAD binding 12/4869 26/18639 0.461538461538462 1.76681359306128 0.0217556346105779 0.0946968561528392 GO:0005543 phospholipid binding 150/4869 497/18639 0.301810865191147 1.15536100149883 0.0220387827077698 0.0956198798127432 GO:0051082 unfolded protein binding 42/4869 121/18639 0.347107438016529 1.32876063610394 0.0222391318320381 0.0958534565176333 GO:0000774 adenyl-nucleotide exchange factor activity 8/4869 15/18639 0.533333333333333 2.04165126309304 0.0224780098929768 0.0958534565176333 GO:0042809 nuclear vitamin D receptor binding 8/4869 15/18639 0.533333333333333 2.04165126309304 0.0224780098929768 0.0958534565176333 GO:0120283 protein serine/threonine kinase binding 8/4869 15/18639 0.533333333333333 2.04165126309304 0.0224780098929768 0.0958534565176333 GO:0140776 protein-containing complex destabilizing activity 8/4869 15/18639 0.533333333333333 2.04165126309304 0.0224780098929768 0.0958534565176333 GO:0061749 forked DNA-dependent helicase activity 19/4869 47/18639 0.404255319148936 1.54752821803595 0.0225914838037842 0.0958534565176333 GO:1990518 single-stranded 3'-5' DNA helicase activity 19/4869 47/18639 0.404255319148936 1.54752821803595 0.0225914838037842 0.0958534565176333 GO:0016279 protein-lysine N-methyltransferase activity 26/4869 69/18639 0.376811594202899 1.44247100109834 0.022922290478534 0.0969511971497741 GO:0120015 sterol transfer activity 14/4869 32/18639 0.4375 1.67479205175601 0.0230414125036113 0.0971495292080165 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 17/4869 41/18639 0.414634146341463 1.58725936612416 0.0231839372480113 0.0974449862455476 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 44/4869 128/18639 0.34375 1.31590804066543 0.0233068809527207 0.0976565572629575 GO:0008276 protein methyltransferase activity 34/4869 95/18639 0.357894736842105 1.37005545286506 0.0235399893449474 0.0983269741271873 GO:0001094 TFIID-class transcription factor complex binding 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:0016427 tRNA (cytidine) methyltransferase activity 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:0030957 Tat protein binding 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:0031434 mitogen-activated protein kinase kinase binding 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 6/4869 10/18639 0.6 2.29685767097967 0.0244376035938742 0.0990017374510866 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 23/4869 60/18639 0.383333333333333 1.46743684534812 0.025370788343866 0.102473604572071 GO:0008525 phosphatidylcholine transporter activity 9/4869 18/18639 0.5 1.91404805914972 0.0255788136519323 0.102697027945818 GO:0098641 cadherin binding involved in cell-cell adhesion 9/4869 18/18639 0.5 1.91404805914972 0.0255788136519323 0.102697027945818 GO:0140463 chromatin-protein adaptor activity 21/4869 54/18639 0.388888888888889 1.48870404600534 0.0269707262682065 0.107963175091481 GO:0016278 lysine N-methyltransferase activity 26/4869 70/18639 0.371428571428571 1.42186427251122 0.0276259979141723 0.109736315910323 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 10/4869 21/18639 0.476190476190476 1.82290291347593 0.0277400352487061 0.109736315910323 GO:0019200 carbohydrate kinase activity 10/4869 21/18639 0.476190476190476 1.82290291347593 0.0277400352487061 0.109736315910323 GO:0070182 DNA polymerase binding 10/4869 21/18639 0.476190476190476 1.82290291347593 0.0277400352487061 0.109736315910323 GO:0009378 four-way junction helicase activity 19/4869 48/18639 0.395833333333333 1.51528804682686 0.0284550523795344 0.111580307435784 GO:0016879 ligase activity, forming carbon-nitrogen bonds 19/4869 48/18639 0.395833333333333 1.51528804682686 0.0284550523795344 0.111580307435784 GO:0043138 3'-5' DNA helicase activity 19/4869 48/18639 0.395833333333333 1.51528804682686 0.0284550523795344 0.111580307435784 GO:0050840 extracellular matrix binding 25/4869 67/18639 0.373134328358209 1.42839407399233 0.0287017737802785 0.112183452264162 GO:0051213 dioxygenase activity 33/4869 93/18639 0.354838709677419 1.35835668713851 0.0287756810640415 0.112183452264162 GO:0140033 acetylation-dependent protein binding 11/4869 24/18639 0.458333333333333 1.75454405422058 0.0291744223491725 0.113409242946928 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 12/4869 27/18639 0.444444444444444 1.70137605257753 0.0300506580411787 0.116478775404569 GO:0016409 palmitoyltransferase activity 15/4869 36/18639 0.416666666666667 1.59504004929144 0.0304881267529741 0.116769383359955 GO:0070566 adenylyltransferase activity 13/4869 30/18639 0.433333333333333 1.65884165126309 0.0304989546635853 0.116769383359955 GO:0046975 histone H3K36 methyltransferase activity 7/4869 13/18639 0.538461538461538 2.06128252523816 0.0306465370454007 0.116769383359955 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 7/4869 13/18639 0.538461538461538 2.06128252523816 0.0306465370454007 0.116769383359955 GO:0140333 glycerophospholipid flippase activity 7/4869 13/18639 0.538461538461538 2.06128252523816 0.0306465370454007 0.116769383359955 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 7/4869 13/18639 0.538461538461538 2.06128252523816 0.0306465370454007 0.116769383359955 GO:0051117 ATPase binding 30/4869 84/18639 0.357142857142857 1.36717718510694 0.0328722875366972 0.124896120725587 GO:0005080 protein kinase C binding 20/4869 52/18639 0.384615384615385 1.4723446608844 0.0342861176125562 0.129900924475741 GO:0032934 sterol binding 25/4869 68/18639 0.367647058823529 1.40738827878656 0.0344210676046106 0.130045887438768 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 8/4869 16/18639 0.5 1.91404805914972 0.034842930298414 0.130539669223863 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 8/4869 16/18639 0.5 1.91404805914972 0.034842930298414 0.130539669223863 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 8/4869 16/18639 0.5 1.91404805914972 0.034842930298414 0.130539669223863 GO:0060590 ATPase regulator activity 19/4869 49/18639 0.387755102040816 1.48436380097325 0.0353892718017823 0.13221825159277 GO:0008170 N-methyltransferase activity 34/4869 98/18639 0.346938775510204 1.32811497981818 0.0370412002421798 0.138006687882914 GO:0004712 protein serine/threonine/tyrosine kinase activity 17/4869 43/18639 0.395348837209302 1.51343334909513 0.0374704326327702 0.138045981113468 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 9/4869 19/18639 0.473684210526316 1.81330868761553 0.0375649286896128 0.138045981113468 GO:0042800 histone H3K4 methyltransferase activity 9/4869 19/18639 0.473684210526316 1.81330868761553 0.0375649286896128 0.138045981113468 GO:0140036 ubiquitin-modified protein reader activity 9/4869 19/18639 0.473684210526316 1.81330868761553 0.0375649286896128 0.138045981113468 GO:1990380 K48-linked deubiquitinase activity 9/4869 19/18639 0.473684210526316 1.81330868761553 0.0375649286896128 0.138045981113468 GO:0019213 deacetylase activity 15/4869 37/18639 0.405405405405405 1.55193085877005 0.0392124335314125 0.14370769236989 GO:0008175 tRNA methyltransferase activity 14/4869 34/18639 0.411764705882353 1.57627487224095 0.0398599507130751 0.145683787252951 GO:0019211 phosphatase activator activity 11/4869 25/18639 0.44 1.68436229205176 0.0400912037487685 0.14573694335701 GO:0042974 nuclear retinoic acid receptor binding 11/4869 25/18639 0.44 1.68436229205176 0.0400912037487685 0.14573694335701 GO:0043022 ribosome binding 38/4869 112/18639 0.339285714285714 1.2988183258516 0.0403030772587871 0.146112234267031 GO:0051018 protein kinase A binding 20/4869 53/18639 0.377358490566038 1.44456457294319 0.0419172273375715 0.149603545895718 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 6/4869 11/18639 0.545454545454545 2.08805242816333 0.0420447140138152 0.149603545895718 GO:0002162 dystroglycan binding 6/4869 11/18639 0.545454545454545 2.08805242816333 0.0420447140138152 0.149603545895718 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 6/4869 11/18639 0.545454545454545 2.08805242816333 0.0420447140138152 0.149603545895718 GO:0034713 type I transforming growth factor beta receptor binding 6/4869 11/18639 0.545454545454545 2.08805242816333 0.0420447140138152 0.149603545895718 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 6/4869 11/18639 0.545454545454545 2.08805242816333 0.0420447140138152 0.149603545895718 GO:0180030 inositol phosphate kinase activity 6/4869 11/18639 0.545454545454545 2.08805242816333 0.0420447140138152 0.149603545895718 GO:0015605 organophosphate ester transmembrane transporter activity 19/4869 50/18639 0.38 1.45467652495379 0.0434902844312271 0.154338872189975 GO:0017022 myosin binding 27/4869 76/18639 0.355263157894737 1.35998151571165 0.0441214136551361 0.155756696499103 GO:0098631 cell adhesion mediator activity 27/4869 76/18639 0.355263157894737 1.35998151571165 0.0441214136551361 0.155756696499103 GO:0019205 nucleobase-containing compound kinase activity 17/4869 44/18639 0.386363636363636 1.47903713661569 0.0466216657012439 0.163723604094447 GO:0043014 alpha-tubulin binding 17/4869 44/18639 0.386363636363636 1.47903713661569 0.0466216657012439 0.163723604094447 GO:0030165 PDZ domain binding 29/4869 83/18639 0.349397590361446 1.33752755940583 0.0468692373004418 0.164164385857016 GO:0042043 neurexin family protein binding 7/4869 14/18639 0.5 1.91404805914972 0.0477388657965404 0.165914145985392 GO:0046030 inositol trisphosphate phosphatase activity 7/4869 14/18639 0.5 1.91404805914972 0.0477388657965404 0.165914145985392 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 7/4869 14/18639 0.5 1.91404805914972 0.0477388657965404 0.165914145985392 GO:0061650 ubiquitin-like protein conjugating enzyme activity 16/4869 41/18639 0.390243902439024 1.49389116811686 0.048139046324236 0.16687375594355 GO:0051087 protein-folding chaperone binding 44/4869 134/18639 0.328358208955224 1.25698678511325 0.0492210641650438 0.170185941650344 GO:0043531 ADP binding 15/4869 38/18639 0.394736842105263 1.51109057301294 0.0495849635418104 0.171004553753167 GO:0017069 snRNA binding 20/4869 54/18639 0.37037037037037 1.41781337714794 0.0507092867901393 0.174434758907257 GO:0048038 quinone binding 8/4869 17/18639 0.470588235294118 1.8014569968468 0.0510872193431079 0.174840483502494 GO:1990226 histone methyltransferase binding 8/4869 17/18639 0.470588235294118 1.8014569968468 0.0510872193431079 0.174840483502494 GO:0030515 snoRNA binding 13/4869 32/18639 0.40625 1.55516404805915 0.0520776202105752 0.17747017823942 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 9/4869 20/18639 0.45 1.72264325323475 0.052864459572589 0.17747017823942 GO:0030742 GTP-dependent protein binding 9/4869 20/18639 0.45 1.72264325323475 0.052864459572589 0.17747017823942 GO:0052745 inositol phosphate phosphatase activity 9/4869 20/18639 0.45 1.72264325323475 0.052864459572589 0.17747017823942 GO:0043548 phosphatidylinositol 3-kinase binding 11/4869 26/18639 0.423076923076923 1.61957912697284 0.0535372877834418 0.17747017823942 GO:0050750 low-density lipoprotein particle receptor binding 11/4869 26/18639 0.423076923076923 1.61957912697284 0.0535372877834418 0.17747017823942 GO:0097602 cullin family protein binding 11/4869 26/18639 0.423076923076923 1.61957912697284 0.0535372877834418 0.17747017823942 GO:0120014 phospholipid transfer activity 11/4869 26/18639 0.423076923076923 1.61957912697284 0.0535372877834418 0.17747017823942 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 10/4869 23/18639 0.434782608695652 1.66438961665193 0.0535709236916018 0.17747017823942 GO:0042171 lysophosphatidic acid acyltransferase activity 10/4869 23/18639 0.434782608695652 1.66438961665193 0.0535709236916018 0.17747017823942 GO:0070577 lysine-acetylated histone binding 10/4869 23/18639 0.434782608695652 1.66438961665193 0.0535709236916018 0.17747017823942 GO:0071617 lysophospholipid acyltransferase activity 10/4869 23/18639 0.434782608695652 1.66438961665193 0.0535709236916018 0.17747017823942 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 10/4869 23/18639 0.434782608695652 1.66438961665193 0.0535709236916018 0.17747017823942 GO:0048029 monosaccharide binding 26/4869 74/18639 0.351351351351351 1.34500674426737 0.0540468046978373 0.178606762453541 GO:0004860 protein kinase inhibitor activity 29/4869 84/18639 0.345238095238095 1.32160461227005 0.0542494471758707 0.178837025616535 GO:0032266 phosphatidylinositol-3-phosphate binding 18/4869 48/18639 0.375 1.43553604436229 0.0550297943459358 0.18096594962172 GO:0004843 cysteine-type deubiquitinase activity 36/4869 108/18639 0.333333333333333 1.27603203943315 0.057295841833125 0.187958310403788 GO:0017116 single-stranded DNA helicase activity 21/4869 58/18639 0.362068965517241 1.38603480145325 0.0580466663401142 0.189958068679936 GO:0101005 deubiquitinase activity 38/4869 115/18639 0.330434782608696 1.26493610865547 0.0586299707011644 0.191401239303558 GO:0003777 microtubule motor activity 24/4869 68/18639 0.352941176470588 1.3510927476351 0.0594637299097482 0.193266598406364 GO:0051879 Hsp90 protein binding 16/4869 42/18639 0.380952380952381 1.45832233078074 0.0594887522232228 0.193266598406364 GO:0000995 RNA polymerase III general transcription initiation factor activity 6/4869 12/18639 0.5 1.91404805914972 0.0658975218321119 0.210527712266486 GO:0031543 peptidyl-proline dioxygenase activity 6/4869 12/18639 0.5 1.91404805914972 0.0658975218321119 0.210527712266486 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 6/4869 12/18639 0.5 1.91404805914972 0.0658975218321119 0.210527712266486 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 6/4869 12/18639 0.5 1.91404805914972 0.0658975218321119 0.210527712266486 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 6/4869 12/18639 0.5 1.91404805914972 0.0658975218321119 0.210527712266486 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 6/4869 12/18639 0.5 1.91404805914972 0.0658975218321119 0.210527712266486 GO:0141221 histone deacetylase activity, hydrolytic mechanism 6/4869 12/18639 0.5 1.91404805914972 0.0658975218321119 0.210527712266486 GO:0035254 glutamate receptor binding 18/4869 49/18639 0.36734693877551 1.40623939039571 0.0664339687264122 0.211738597007167 GO:0015215 nucleotide transmembrane transporter activity 12/4869 30/18639 0.4 1.53123844731978 0.0679801939149257 0.215644718904658 GO:0035925 mRNA 3'-UTR AU-rich region binding 12/4869 30/18639 0.4 1.53123844731978 0.0679801939149257 0.215644718904658 GO:0004879 nuclear receptor activity 21/4869 59/18639 0.355932203389831 1.36254268617438 0.0686703846117496 0.217321570124243 GO:0005385 zinc ion transmembrane transporter activity 11/4869 27/18639 0.407407407407407 1.55959471486274 0.0696843457312477 0.217448250666327 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 7/4869 15/18639 0.466666666666667 1.78644485520641 0.0698421147121585 0.217448250666327 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 7/4869 15/18639 0.466666666666667 1.78644485520641 0.0698421147121585 0.217448250666327 GO:0031005 filamin binding 7/4869 15/18639 0.466666666666667 1.78644485520641 0.0698421147121585 0.217448250666327 GO:0061578 K63-linked deubiquitinase activity 7/4869 15/18639 0.466666666666667 1.78644485520641 0.0698421147121585 0.217448250666327 GO:0141050 histone H3K deacetylase activity 7/4869 15/18639 0.466666666666667 1.78644485520641 0.0698421147121585 0.217448250666327 GO:0141051 histone H4K deacetylase activity 7/4869 15/18639 0.466666666666667 1.78644485520641 0.0698421147121585 0.217448250666327 GO:0004706 JUN kinase kinase kinase activity 8/4869 18/18639 0.444444444444444 1.70137605257753 0.0714939438960484 0.219696950254781 GO:0070628 proteasome binding 8/4869 18/18639 0.444444444444444 1.70137605257753 0.0714939438960484 0.219696950254781 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 9/4869 21/18639 0.428571428571429 1.64061262212833 0.0717077778155011 0.219696950254781 GO:0009931 calcium-dependent protein serine/threonine kinase activity 9/4869 21/18639 0.428571428571429 1.64061262212833 0.0717077778155011 0.219696950254781 GO:0035613 RNA stem-loop binding 9/4869 21/18639 0.428571428571429 1.64061262212833 0.0717077778155011 0.219696950254781 GO:0051010 microtubule plus-end binding 9/4869 21/18639 0.428571428571429 1.64061262212833 0.0717077778155011 0.219696950254781 GO:0072542 protein phosphatase activator activity 9/4869 21/18639 0.428571428571429 1.64061262212833 0.0717077778155011 0.219696950254781 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 15/4869 40/18639 0.375 1.43553604436229 0.0757156368557729 0.23144893538867 GO:0019210 kinase inhibitor activity 30/4869 90/18639 0.333333333333333 1.27603203943315 0.0772984537649219 0.235751519985986 GO:0003697 single-stranded DNA binding 39/4869 121/18639 0.322314049586777 1.23384916209652 0.078378654051555 0.237966793903705 GO:0004540 RNA nuclease activity 39/4869 121/18639 0.322314049586777 1.23384916209652 0.078378654051555 0.237966793903705 GO:0097110 scaffold protein binding 24/4869 70/18639 0.342857142857143 1.31249009770267 0.0802794281082321 0.243188808120658 GO:0098531 ligand-modulated transcription factor activity 21/4869 60/18639 0.35 1.33983364140481 0.0805486229422675 0.243455950241235 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 56/4869 181/18639 0.30939226519337 1.18438332941861 0.0828608709849876 0.249883119898673 GO:0016504 peptidase activator activity 20/4869 57/18639 0.350877192982456 1.34319162045595 0.0847182649982089 0.254912900274253 GO:0070273 phosphatidylinositol-4-phosphate binding 12/4869 31/18639 0.387096774193548 1.48184365869656 0.0854740042845921 0.256612803041912 GO:0019838 growth factor binding 43/4869 136/18639 0.316176470588235 1.21035391975644 0.0877799999854072 0.262353250204723 GO:0019789 SUMO transferase activity 11/4869 28/18639 0.392857142857143 1.50389490361764 0.0886358733522045 0.262353250204723 GO:0046875 ephrin receptor binding 11/4869 28/18639 0.392857142857143 1.50389490361764 0.0886358733522045 0.262353250204723 GO:0051959 dynein light intermediate chain binding 11/4869 28/18639 0.392857142857143 1.50389490361764 0.0886358733522045 0.262353250204723 GO:0051287 NAD binding 19/4869 54/18639 0.351851851851852 1.34692270829055 0.089127297668404 0.262353250204723 GO:0019706 protein-cysteine S-palmitoyltransferase activity 10/4869 25/18639 0.4 1.53123844731978 0.0916008576325731 0.262353250204723 GO:0019707 protein-cysteine S-acyltransferase activity 10/4869 25/18639 0.4 1.53123844731978 0.0916008576325731 0.262353250204723 GO:0120020 cholesterol transfer activity 10/4869 25/18639 0.4 1.53123844731978 0.0916008576325731 0.262353250204723 GO:0000182 rDNA binding 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0004382 GDP phosphatase activity 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0004445 inositol-polyphosphate 5-phosphatase activity 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0008140 cAMP response element binding protein binding 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0015643 toxic substance binding 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0016303 1-phosphatidylinositol-3-kinase activity 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0050815 phosphoserine residue binding 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0051864 histone H3K36 demethylase activity 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0070097 delta-catenin binding 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0070513 death domain binding 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0070739 protein-glutamic acid ligase activity 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0070740 tubulin-glutamic acid ligase activity 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0098505 G-rich strand telomeric DNA binding 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0140999 histone H3K4 trimethyltransferase activity 5/4869 10/18639 0.5 1.91404805914972 0.0918724021163008 0.262353250204723 GO:0031683 G-protein beta/gamma-subunit complex binding 9/4869 22/18639 0.409090909090909 1.5660393211225 0.0942012036156189 0.267300883677231 GO:0061133 endopeptidase activator activity 9/4869 22/18639 0.409090909090909 1.5660393211225 0.0942012036156189 0.267300883677231 GO:0140035 ubiquitin-like protein reader activity 9/4869 22/18639 0.409090909090909 1.5660393211225 0.0942012036156189 0.267300883677231 GO:0005172 vascular endothelial growth factor receptor binding 6/4869 13/18639 0.461538461538462 1.76681359306128 0.0961126516492929 0.270291262904551 GO:0019855 calcium channel inhibitor activity 6/4869 13/18639 0.461538461538462 1.76681359306128 0.0961126516492929 0.270291262904551 GO:0097157 pre-mRNA intronic binding 6/4869 13/18639 0.461538461538462 1.76681359306128 0.0961126516492929 0.270291262904551 GO:0042577 lipid phosphatase activity 8/4869 19/18639 0.421052631578947 1.61182994454713 0.0961695913189104 0.270291262904551 GO:0004708 MAP kinase kinase activity 7/4869 16/18639 0.4375 1.67479205175601 0.0970637025895155 0.270291262904551 GO:0005159 insulin-like growth factor receptor binding 7/4869 16/18639 0.4375 1.67479205175601 0.0970637025895155 0.270291262904551 GO:0005521 lamin binding 7/4869 16/18639 0.4375 1.67479205175601 0.0970637025895155 0.270291262904551 GO:0008142 oxysterol binding 7/4869 16/18639 0.4375 1.67479205175601 0.0970637025895155 0.270291262904551 GO:0055102 lipase inhibitor activity 7/4869 16/18639 0.4375 1.67479205175601 0.0970637025895155 0.270291262904551 GO:0043015 gamma-tubulin binding 13/4869 35/18639 0.371428571428571 1.42186427251122 0.100722585654154 0.279900573770325 GO:0160215 deacylase activity 22/4869 65/18639 0.338461538461538 1.29566330157827 0.102575280709393 0.28446134547244 GO:0046915 transition metal ion transmembrane transporter activity 16/4869 45/18639 0.355555555555556 1.36110084206202 0.103949531529963 0.287679259069549 GO:0005518 collagen binding 24/4869 72/18639 0.333333333333333 1.27603203943315 0.105495851234175 0.290806183833008 GO:0140142 nucleocytoplasmic carrier activity 12/4869 32/18639 0.375 1.43553604436229 0.105511834729002 0.290806183833008 GO:0016417 S-acyltransferase activity 11/4869 29/18639 0.379310344827586 1.45203645866531 0.110420869269758 0.303713842878987 GO:0005160 transforming growth factor beta receptor binding 10/4869 26/18639 0.384615384615385 1.4723446608844 0.11539058878828 0.313536044283306 GO:0008143 poly(A) binding 10/4869 26/18639 0.384615384615385 1.4723446608844 0.11539058878828 0.313536044283306 GO:0008198 ferrous iron binding 10/4869 26/18639 0.384615384615385 1.4723446608844 0.11539058878828 0.313536044283306 GO:0015216 purine nucleotide transmembrane transporter activity 10/4869 26/18639 0.384615384615385 1.4723446608844 0.11539058878828 0.313536044283306 GO:0034237 protein kinase A regulatory subunit binding 10/4869 26/18639 0.384615384615385 1.4723446608844 0.11539058878828 0.313536044283306 GO:0070006 metalloaminopeptidase activity 10/4869 26/18639 0.384615384615385 1.4723446608844 0.11539058878828 0.313536044283306 GO:0000295 adenine nucleotide transmembrane transporter activity 9/4869 23/18639 0.391304347826087 1.49795065498674 0.120320669281059 0.325616298154977 GO:0005158 insulin receptor binding 9/4869 23/18639 0.391304347826087 1.49795065498674 0.120320669281059 0.325616298154977 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 16/4869 46/18639 0.347826086956522 1.33151169332155 0.122355472928575 0.330458054395448 GO:0000339 RNA cap binding 8/4869 20/18639 0.4 1.53123844731978 0.125039679149791 0.335685366180578 GO:0042288 MHC class I protein binding 8/4869 20/18639 0.4 1.53123844731978 0.125039679149791 0.335685366180578 GO:0061608 nuclear import signal receptor activity 8/4869 20/18639 0.4 1.53123844731978 0.125039679149791 0.335685366180578 GO:0016758 hexosyltransferase activity 59/4869 197/18639 0.299492385786802 1.1464856394907 0.126289204744388 0.338364502751398 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 7/4869 17/18639 0.411764705882353 1.57627487224095 0.129247240862 0.340449553310487 GO:0019198 transmembrane receptor protein phosphatase activity 7/4869 17/18639 0.411764705882353 1.57627487224095 0.129247240862 0.340449553310487 GO:0070403 NAD+ binding 7/4869 17/18639 0.411764705882353 1.57627487224095 0.129247240862 0.340449553310487 GO:0005347 ATP transmembrane transporter activity 6/4869 14/18639 0.428571428571429 1.64061262212833 0.132392991038858 0.340449553310487 GO:0005545 1-phosphatidylinositol binding 6/4869 14/18639 0.428571428571429 1.64061262212833 0.132392991038858 0.340449553310487 GO:0008191 metalloendopeptidase inhibitor activity 6/4869 14/18639 0.428571428571429 1.64061262212833 0.132392991038858 0.340449553310487 GO:0008195 phosphatidate phosphatase activity 6/4869 14/18639 0.428571428571429 1.64061262212833 0.132392991038858 0.340449553310487 GO:0008474 palmitoyl-(protein) hydrolase activity 6/4869 14/18639 0.428571428571429 1.64061262212833 0.132392991038858 0.340449553310487 GO:0030983 mismatched DNA binding 6/4869 14/18639 0.428571428571429 1.64061262212833 0.132392991038858 0.340449553310487 GO:0098599 palmitoyl hydrolase activity 6/4869 14/18639 0.428571428571429 1.64061262212833 0.132392991038858 0.340449553310487 GO:1990825 sequence-specific mRNA binding 6/4869 14/18639 0.428571428571429 1.64061262212833 0.132392991038858 0.340449553310487 GO:0003953 NAD+ nucleosidase activity 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0004143 ATP-dependent diacylglycerol kinase activity 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0005225 volume-sensitive anion channel activity 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0005536 D-glucose binding 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0019107 myristoyltransferase activity 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0032050 clathrin heavy chain binding 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0034056 estrogen response element binding 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0035252 UDP-xylosyltransferase activity 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0042285 xylosyltransferase activity 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0042608 T cell receptor binding 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0045294 alpha-catenin binding 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0070697 activin receptor binding 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0070990 snRNP binding 5/4869 11/18639 0.454545454545455 1.74004369013611 0.133395475535039 0.340449553310487 GO:0016769 transferase activity, transferring nitrogenous groups 11/4869 30/18639 0.366666666666667 1.40363524337646 0.13499178658045 0.3438711230127 GO:0004177 aminopeptidase activity 14/4869 40/18639 0.35 1.33983364140481 0.136663550263369 0.346815990762701 GO:0030331 nuclear estrogen receptor binding 14/4869 40/18639 0.35 1.33983364140481 0.136663550263369 0.346815990762701 GO:0015932 nucleobase-containing compound transmembrane transporter activity 19/4869 57/18639 0.333333333333333 1.27603203943315 0.138501406209789 0.350818062810107 GO:0035255 ionotropic glutamate receptor binding 10/4869 27/18639 0.37037037037037 1.41781337714794 0.142276614115946 0.359703093958548 GO:0008194 UDP-glycosyltransferase activity 44/4869 145/18639 0.303448275862069 1.16162916693225 0.143343232951663 0.361719790469019 GO:0003925 G protein activity 18/4869 54/18639 0.333333333333333 1.27603203943315 0.146536744797555 0.368396115425628 GO:0015485 cholesterol binding 18/4869 54/18639 0.333333333333333 1.27603203943315 0.146536744797555 0.368396115425628 GO:0019905 syntaxin binding 20/4869 61/18639 0.327868852459016 1.25511348140965 0.149190464677707 0.374367863790141 GO:0035035 histone acetyltransferase binding 9/4869 24/18639 0.375 1.43553604436229 0.149914873202262 0.374787183005656 GO:0050431 transforming growth factor beta binding 9/4869 24/18639 0.375 1.43553604436229 0.149914873202262 0.374787183005656 GO:0016248 channel inhibitor activity 15/4869 44/18639 0.340909090909091 1.30503276760208 0.150954074088097 0.376685027177163 GO:0140272 exogenous protein binding 26/4869 82/18639 0.317073170731707 1.21378657409495 0.152128477047431 0.37891259560888 GO:0008376 acetylgalactosaminyltransferase activity 12/4869 34/18639 0.352941176470588 1.3510927476351 0.153085594776342 0.379889529472656 GO:0030332 cyclin binding 12/4869 34/18639 0.352941176470588 1.3510927476351 0.153085594776342 0.379889529472656 GO:0003743 translation initiation factor activity 17/4869 51/18639 0.333333333333333 1.27603203943315 0.155163355171292 0.384336487486902 GO:0008373 sialyltransferase activity 8/4869 21/18639 0.380952380952381 1.45832233078074 0.157859310740124 0.388865884515507 GO:0010314 phosphatidylinositol-5-phosphate binding 8/4869 21/18639 0.380952380952381 1.45832233078074 0.157859310740124 0.388865884515507 GO:0140312 cargo adaptor activity 8/4869 21/18639 0.380952380952381 1.45832233078074 0.157859310740124 0.388865884515507 GO:0042169 SH2 domain binding 14/4869 41/18639 0.341463414634146 1.30715477210225 0.160016764606307 0.393459869095946 GO:0016411 acylglycerol O-acyltransferase activity 11/4869 31/18639 0.354838709677419 1.35835668713851 0.162226566843173 0.398165570080414 GO:0000900 mRNA regulatory element binding translation repressor activity 7/4869 18/18639 0.388888888888889 1.48870404600534 0.165999338931243 0.405943837931858 GO:0008409 5'-3' exonuclease activity 7/4869 18/18639 0.388888888888889 1.48870404600534 0.165999338931243 0.405943837931858 GO:0008374 O-acyltransferase activity 18/4869 55/18639 0.327272727272727 1.252831456898 0.167175743472295 0.40807872045415 GO:0097718 disordered domain specific binding 10/4869 28/18639 0.357142857142857 1.36717718510694 0.172077025651358 0.419281883154125 GO:0010181 FMN binding 6/4869 15/18639 0.4 1.53123844731978 0.174093575256656 0.42190244814451 GO:0015556 C4-dicarboxylate transmembrane transporter activity 6/4869 15/18639 0.4 1.53123844731978 0.174093575256656 0.42190244814451 GO:0045504 dynein heavy chain binding 6/4869 15/18639 0.4 1.53123844731978 0.174093575256656 0.42190244814451 GO:0141110 transporter inhibitor activity 15/4869 45/18639 0.333333333333333 1.27603203943315 0.174456345367165 0.422021195177764 GO:0000049 tRNA binding 25/4869 80/18639 0.3125 1.19628003696858 0.178234141217709 0.43004077988294 GO:0005154 epidermal growth factor receptor binding 12/4869 35/18639 0.342857142857143 1.31249009770267 0.180405425622701 0.43004077988294 GO:0000340 RNA 7-methylguanosine cap binding 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:0004000 adenosine deaminase activity 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:0004300 enoyl-CoA hydratase activity 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:0005095 GTPase inhibitor activity 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:0005527 macrolide binding 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:0034452 dynactin binding 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:0035197 siRNA binding 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:0035497 cAMP response element binding 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:1990817 poly(A) RNA polymerase activity 5/4869 12/18639 0.416666666666667 1.59504004929144 0.181608299608557 0.43004077988294 GO:0017056 structural constituent of nuclear pore 9/4869 25/18639 0.36 1.3781146025878 0.182716506960213 0.43190457269154 GO:0008307 structural constituent of muscle 14/4869 42/18639 0.333333333333333 1.27603203943315 0.185285749392141 0.436443665380788 GO:0042056 chemoattractant activity 14/4869 42/18639 0.333333333333333 1.27603203943315 0.185285749392141 0.436443665380788 GO:0008649 rRNA methyltransferase activity 8/4869 22/18639 0.363636363636364 1.39203495210889 0.194235371954127 0.454341870049219 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 8/4869 22/18639 0.363636363636364 1.39203495210889 0.194235371954127 0.454341870049219 GO:0034062 5'-3' RNA polymerase activity 8/4869 22/18639 0.363636363636364 1.39203495210889 0.194235371954127 0.454341870049219 GO:0097747 RNA polymerase activity 8/4869 22/18639 0.363636363636364 1.39203495210889 0.194235371954127 0.454341870049219 GO:0001618 virus receptor activity 25/4869 81/18639 0.308641975308642 1.18151114762329 0.196957317075823 0.459909012963509 GO:0030276 clathrin binding 15/4869 46/18639 0.326086956521739 1.24829221248895 0.199666444934225 0.46438467517399 GO:0030291 protein serine/threonine kinase inhibitor activity 15/4869 46/18639 0.326086956521739 1.24829221248895 0.199666444934225 0.46438467517399 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 21/4869 67/18639 0.313432835820896 1.19985102215356 0.199909834145532 0.46438467517399 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 19/4869 60/18639 0.316666666666667 1.21223043746149 0.2006759469116 0.464625020465204 GO:0038064 collagen receptor activity 17/4869 53/18639 0.320754716981132 1.22787988700171 0.200704190996493 0.464625020465204 GO:1990782 protein tyrosine kinase binding 35/4869 117/18639 0.299145299145299 1.14515695846565 0.201519697330733 0.465711328023772 GO:0043178 alcohol binding 28/4869 92/18639 0.304347826086957 1.16507273165635 0.203012717781975 0.468356956117935 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 10/4869 29/18639 0.344827586206897 1.32003314424119 0.204527634273253 0.468636572568187 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 10/4869 29/18639 0.344827586206897 1.32003314424119 0.204527634273253 0.468636572568187 GO:0097472 cyclin-dependent protein kinase activity 10/4869 29/18639 0.344827586206897 1.32003314424119 0.204527634273253 0.468636572568187 GO:0106222 lncRNA binding 10/4869 29/18639 0.344827586206897 1.32003314424119 0.204527634273253 0.468636572568187 GO:0005346 purine ribonucleotide transmembrane transporter activity 7/4869 19/18639 0.368421052631579 1.41035120147874 0.20673335837177 0.471739139340798 GO:0022821 solute:potassium antiporter activity 7/4869 19/18639 0.368421052631579 1.41035120147874 0.20673335837177 0.471739139340798 GO:0140101 catalytic activity, acting on a tRNA 41/4869 139/18639 0.294964028776978 1.12915065359912 0.206933897554699 0.471739139340798 GO:0008200 ion channel inhibitor activity 14/4869 43/18639 0.325581395348837 1.2463568757254 0.212328205878322 0.48240107585531 GO:0008375 acetylglucosaminyltransferase activity 14/4869 43/18639 0.325581395348837 1.2463568757254 0.212328205878322 0.48240107585531 GO:0002020 protease binding 40/4869 136/18639 0.294117647058824 1.12591062302925 0.216402577839154 0.490828781102297 GO:0004435 phosphatidylinositol phospholipase C activity 9/4869 26/18639 0.346153846153846 1.32511019479596 0.21835964011006 0.49360288394627 GO:0030247 polysaccharide binding 9/4869 26/18639 0.346153846153846 1.32511019479596 0.21835964011006 0.49360288394627 GO:0015385 sodium:proton antiporter activity 6/4869 16/18639 0.375 1.43553604436229 0.220311498856941 0.496346676654248 GO:0097027 ubiquitin-protein transferase activator activity 6/4869 16/18639 0.375 1.43553604436229 0.220311498856941 0.496346676654248 GO:0140311 protein sequestering activity 11/4869 33/18639 0.333333333333333 1.27603203943315 0.223863725552863 0.503506205465888 GO:0050661 NADP binding 17/4869 54/18639 0.314814814814815 1.20514137057575 0.225591936547357 0.506546168040393 GO:0043495 protein-membrane adaptor activity 15/4869 47/18639 0.319148936170213 1.22173280371259 0.226445057291335 0.50761433676141 GO:0003887 DNA-directed DNA polymerase activity 8/4869 23/18639 0.347826086956522 1.33151169332155 0.233656546713097 0.516557094835403 GO:0043274 phospholipase binding 8/4869 23/18639 0.347826086956522 1.33151169332155 0.233656546713097 0.516557094835403 GO:0140102 catalytic activity, acting on a rRNA 8/4869 23/18639 0.347826086956522 1.33151169332155 0.233656546713097 0.516557094835403 GO:0004535 poly(A)-specific ribonuclease activity 5/4869 13/18639 0.384615384615385 1.4723446608844 0.235043079583098 0.516557094835403 GO:0008253 5'-nucleotidase activity 5/4869 13/18639 0.384615384615385 1.4723446608844 0.235043079583098 0.516557094835403 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 5/4869 13/18639 0.384615384615385 1.4723446608844 0.235043079583098 0.516557094835403 GO:0039706 co-receptor binding 5/4869 13/18639 0.384615384615385 1.4723446608844 0.235043079583098 0.516557094835403 GO:0043560 insulin receptor substrate binding 5/4869 13/18639 0.384615384615385 1.4723446608844 0.235043079583098 0.516557094835403 GO:0045159 myosin II binding 5/4869 13/18639 0.384615384615385 1.4723446608844 0.235043079583098 0.516557094835403 GO:0051011 microtubule minus-end binding 5/4869 13/18639 0.384615384615385 1.4723446608844 0.235043079583098 0.516557094835403 GO:0071714 icosanoid transmembrane transporter activity 5/4869 13/18639 0.384615384615385 1.4723446608844 0.235043079583098 0.516557094835403 GO:0140666 annealing activity 5/4869 13/18639 0.384615384615385 1.4723446608844 0.235043079583098 0.516557094835403 GO:0001968 fibronectin binding 10/4869 30/18639 0.333333333333333 1.27603203943315 0.239295558119654 0.524716824172692 GO:0005010 insulin-like growth factor receptor activity 16/4869 51/18639 0.313725490196078 1.2009713312312 0.23953615616508 0.524716824172692 GO:0004519 endonuclease activity 37/4869 127/18639 0.291338582677165 1.11527209745732 0.247523886033523 0.537297644036474 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 7/4869 20/18639 0.35 1.33983364140481 0.250722262568221 0.537297644036474 GO:0043024 ribosomal small subunit binding 7/4869 20/18639 0.35 1.33983364140481 0.250722262568221 0.537297644036474 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0004862 cAMP-dependent protein kinase inhibitor activity 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0005528 FK506 binding 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0008641 ubiquitin-like modifier activating enzyme activity 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0016868 intramolecular phosphotransferase activity 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0042975 peroxisome proliferator activated receptor binding 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0043422 protein kinase B binding 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0045322 unmethylated CpG binding 4/4869 10/18639 0.4 1.53123844731978 0.250872059817774 0.537297644036474 GO:0098632 cell-cell adhesion mediator activity 17/4869 55/18639 0.309090909090909 1.18322970929256 0.251725496607254 0.538268351250805 GO:0001671 ATPase activator activity 9/4869 27/18639 0.333333333333333 1.27603203943315 0.256401153107117 0.547366994750433 GO:0140828 metal cation:monoatomic cation antiporter activity 13/4869 41/18639 0.317073170731707 1.21378657409495 0.256794478578084 0.547366994750433 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 11/4869 34/18639 0.323529411764706 1.23850168533217 0.257714135924243 0.548458089902068 GO:0070888 E-box binding 18/4869 59/18639 0.305084745762712 1.16789373100661 0.263118146849917 0.559074103496269 GO:0019842 vitamin binding 43/4869 150/18639 0.286666666666667 1.09738755391251 0.2651095875461 0.56241702720742 GO:0004550 nucleoside diphosphate kinase activity 6/4869 17/18639 0.352941176470588 1.3510927476351 0.269982912308727 0.56738596414881 GO:0008484 sulfuric ester hydrolase activity 6/4869 17/18639 0.352941176470588 1.3510927476351 0.269982912308727 0.56738596414881 GO:0008569 minus-end-directed microtubule motor activity 6/4869 17/18639 0.352941176470588 1.3510927476351 0.269982912308727 0.56738596414881 GO:0031489 myosin V binding 6/4869 17/18639 0.352941176470588 1.3510927476351 0.269982912308727 0.56738596414881 GO:0046965 nuclear retinoid X receptor binding 6/4869 17/18639 0.352941176470588 1.3510927476351 0.269982912308727 0.56738596414881 GO:0070402 NADPH binding 6/4869 17/18639 0.352941176470588 1.3510927476351 0.269982912308727 0.56738596414881 GO:0051539 4 iron, 4 sulfur cluster binding 14/4869 45/18639 0.311111111111111 1.19096323680427 0.271007651515447 0.568651000449729 GO:0030971 receptor tyrosine kinase binding 24/4869 81/18639 0.296296296296296 1.13425070171835 0.272268599574228 0.570406957051926 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 8/4869 24/18639 0.333333333333333 1.27603203943315 0.275527383468514 0.575441507399303 GO:0070840 dynein complex binding 8/4869 24/18639 0.333333333333333 1.27603203943315 0.275527383468514 0.575441507399303 GO:0072349 modified amino acid transmembrane transporter activity 10/4869 31/18639 0.32258064516129 1.23486971558047 0.275995077775123 0.575524619546573 GO:0035064 methylated histone binding 22/4869 74/18639 0.297297297297297 1.1380826297647 0.277983159152061 0.578772986160251 GO:0019955 cytokine binding 41/4869 144/18639 0.284722222222222 1.08994403368248 0.287972380596261 0.598644284237977 GO:0008559 ABC-type xenobiotic transporter activity 5/4869 14/18639 0.357142857142857 1.36717718510694 0.29207090655212 0.600665702312847 GO:0015386 potassium:proton antiporter activity 5/4869 14/18639 0.357142857142857 1.36717718510694 0.29207090655212 0.600665702312847 GO:0032036 myosin heavy chain binding 5/4869 14/18639 0.357142857142857 1.36717718510694 0.29207090655212 0.600665702312847 GO:0034236 protein kinase A catalytic subunit binding 5/4869 14/18639 0.357142857142857 1.36717718510694 0.29207090655212 0.600665702312847 GO:0042813 Wnt receptor activity 5/4869 14/18639 0.357142857142857 1.36717718510694 0.29207090655212 0.600665702312847 GO:0044548 S100 protein binding 5/4869 14/18639 0.357142857142857 1.36717718510694 0.29207090655212 0.600665702312847 GO:0070742 C2H2 zinc finger domain binding 5/4869 14/18639 0.357142857142857 1.36717718510694 0.29207090655212 0.600665702312847 GO:0034061 DNA polymerase activity 11/4869 35/18639 0.314285714285714 1.20311592289411 0.29314729481245 0.601958948889688 GO:0016829 lyase activity 56/4869 200/18639 0.28 1.07186691312384 0.29609161689102 0.606671075102486 GO:0050698 proteoglycan sulfotransferase activity 9/4869 28/18639 0.321428571428571 1.23045946659625 0.296344160849319 0.606671075102486 GO:0004536 DNA nuclease activity 19/4869 64/18639 0.296875 1.13646603512015 0.300101114525101 0.613428569963922 GO:0016874 ligase activity 47/4869 167/18639 0.281437125748503 1.0773683686232 0.301943773917198 0.616101800505868 GO:0019003 GDP binding 22/4869 75/18639 0.293333333333333 1.12290819470117 0.302325047088381 0.616101800505868 GO:0005496 steroid binding 31/4869 108/18639 0.287037037037037 1.09880536728966 0.303212363982839 0.616630887691316 GO:1901681 sulfur compound binding 76/4869 275/18639 0.276363636363636 1.05794656360276 0.303501596767027 0.616630887691316 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 12/4869 39/18639 0.307692307692308 1.17787572870752 0.308362361752853 0.625561653933012 GO:0030145 manganese ion binding 20/4869 68/18639 0.294117647058824 1.12591062302925 0.309703248624631 0.626392284812223 GO:0140223 general transcription initiation factor activity 20/4869 68/18639 0.294117647058824 1.12591062302925 0.309703248624631 0.626392284812223 GO:0016835 carbon-oxygen lyase activity 23/4869 79/18639 0.291139240506329 1.11450899646693 0.310843629945691 0.627754778193624 GO:0031369 translation initiation factor binding 10/4869 32/18639 0.3125 1.19628003696858 0.314204529643414 0.63310850106137 GO:0005006 epidermal growth factor receptor activity 15/4869 50/18639 0.3 1.14842883548983 0.31443604364981 0.63310850106137 GO:0015173 aromatic amino acid transmembrane transporter activity 4/4869 11/18639 0.363636363636364 1.39203495210889 0.318001536550766 0.634049736678765 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 4/4869 11/18639 0.363636363636364 1.39203495210889 0.318001536550766 0.634049736678765 GO:0034511 U3 snoRNA binding 4/4869 11/18639 0.363636363636364 1.39203495210889 0.318001536550766 0.634049736678765 GO:0047676 arachidonate-CoA ligase activity 4/4869 11/18639 0.363636363636364 1.39203495210889 0.318001536550766 0.634049736678765 GO:0048185 activin binding 4/4869 11/18639 0.363636363636364 1.39203495210889 0.318001536550766 0.634049736678765 GO:0050998 nitric-oxide synthase binding 4/4869 11/18639 0.363636363636364 1.39203495210889 0.318001536550766 0.634049736678765 GO:0005201 extracellular matrix structural constituent 47/4869 168/18639 0.279761904761905 1.07095546166711 0.318521770217255 0.634049736678765 GO:0008483 transaminase activity 8/4869 25/18639 0.32 1.22499075785582 0.319203090060656 0.634049736678765 GO:0017025 TBP-class protein binding 8/4869 25/18639 0.32 1.22499075785582 0.319203090060656 0.634049736678765 GO:0003746 translation elongation factor activity 6/4869 18/18639 0.333333333333333 1.27603203943315 0.321974698997469 0.634049736678765 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity 6/4869 18/18639 0.333333333333333 1.27603203943315 0.321974698997469 0.634049736678765 GO:0017075 syntaxin-1 binding 6/4869 18/18639 0.333333333333333 1.27603203943315 0.321974698997469 0.634049736678765 GO:0017128 phospholipid scramblase activity 6/4869 18/18639 0.333333333333333 1.27603203943315 0.321974698997469 0.634049736678765 GO:0035615 clathrin adaptor activity 6/4869 18/18639 0.333333333333333 1.27603203943315 0.321974698997469 0.634049736678765 GO:1990381 ubiquitin-specific protease binding 6/4869 18/18639 0.333333333333333 1.27603203943315 0.321974698997469 0.634049736678765 GO:0015297 antiporter activity 38/4869 135/18639 0.281481481481481 1.07753816663244 0.325781366277375 0.640608095969399 GO:0140034 methylation-dependent protein binding 22/4869 76/18639 0.289473684210526 1.10813308687616 0.327306019581626 0.64266656399604 GO:0045505 dynein intermediate chain binding 11/4869 36/18639 0.305555555555556 1.16969603614705 0.329800158869009 0.646619845012853 GO:0048306 calcium-dependent protein binding 23/4869 80/18639 0.2875 1.10057763401109 0.335413071037558 0.656667511711086 GO:0004629 phospholipase C activity 9/4869 29/18639 0.310344827586207 1.18802982981707 0.337661597808548 0.659150724314219 GO:0043236 laminin binding 9/4869 29/18639 0.310344827586207 1.18802982981707 0.337661597808548 0.659150724314219 GO:0050997 quaternary ammonium group binding 12/4869 40/18639 0.3 1.14842883548983 0.343613861667124 0.668908811491936 GO:0044325 transmembrane transporter binding 38/4869 136/18639 0.279411764705882 1.06961509187779 0.34478235134809 0.668908811491936 GO:0004222 metalloendopeptidase activity 31/4869 110/18639 0.281818181818182 1.07882708788439 0.345096419541196 0.668908811491936 GO:0008093 cytoskeletal anchor activity 7/4869 22/18639 0.318181818181818 1.21803058309528 0.345182309528735 0.668908811491936 GO:0005030 neurotrophin receptor activity 15/4869 51/18639 0.294117647058824 1.12591062302925 0.345644330101781 0.668908811491936 GO:0016830 carbon-carbon lyase activity 15/4869 51/18639 0.294117647058824 1.12591062302925 0.345644330101781 0.668908811491936 GO:0005523 tropomyosin binding 5/4869 15/18639 0.333333333333333 1.27603203943315 0.351059572199852 0.674535892298288 GO:0008252 nucleotidase activity 5/4869 15/18639 0.333333333333333 1.27603203943315 0.351059572199852 0.674535892298288 GO:0016846 carbon-sulfur lyase activity 5/4869 15/18639 0.333333333333333 1.27603203943315 0.351059572199852 0.674535892298288 GO:0033130 acetylcholine receptor binding 5/4869 15/18639 0.333333333333333 1.27603203943315 0.351059572199852 0.674535892298288 GO:0050700 CARD domain binding 5/4869 15/18639 0.333333333333333 1.27603203943315 0.351059572199852 0.674535892298288 GO:0004529 DNA exonuclease activity 8/4869 26/18639 0.307692307692308 1.17787572870752 0.364022401149809 0.695468934014905 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 8/4869 26/18639 0.307692307692308 1.17787572870752 0.364022401149809 0.695468934014905 GO:0030507 spectrin binding 8/4869 26/18639 0.307692307692308 1.17787572870752 0.364022401149809 0.695468934014905 GO:0051139 metal cation:proton antiporter activity 8/4869 26/18639 0.307692307692308 1.17787572870752 0.364022401149809 0.695468934014905 GO:1902936 phosphatidylinositol bisphosphate binding 31/4869 111/18639 0.279279279279279 1.06910792493048 0.366578670864927 0.699359308245854 GO:0031420 alkali metal ion binding 6/4869 19/18639 0.315789473684211 1.20887245841035 0.375163010055484 0.711556874663583 GO:0097001 ceramide binding 6/4869 19/18639 0.315789473684211 1.20887245841035 0.375163010055484 0.711556874663583 GO:0017080 sodium channel regulator activity 12/4869 41/18639 0.292682926829268 1.12041837608764 0.379539123635002 0.711556874663583 GO:0042287 MHC protein binding 12/4869 41/18639 0.292682926829268 1.12041837608764 0.379539123635002 0.711556874663583 GO:0001965 G-protein alpha-subunit binding 9/4869 30/18639 0.3 1.14842883548983 0.37981847196093 0.711556874663583 GO:0008106 alcohol dehydrogenase (NADP+) activity 9/4869 30/18639 0.3 1.14842883548983 0.37981847196093 0.711556874663583 GO:0033612 receptor serine/threonine kinase binding 9/4869 30/18639 0.3 1.14842883548983 0.37981847196093 0.711556874663583 GO:0003995 acyl-CoA dehydrogenase activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0004526 ribonuclease P activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0004859 phospholipase inhibitor activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0005049 nuclear export signal receptor activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0008603 cAMP-dependent protein kinase regulator activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0015132 prostaglandin transmembrane transporter activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0016208 AMP binding 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0016273 arginine N-methyltransferase activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0016274 protein-arginine N-methyltransferase activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0016423 tRNA (guanine) methyltransferase activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0016801 hydrolase activity, acting on ether bonds 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0016803 ether hydrolase activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0042301 phosphate ion binding 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0045295 gamma-catenin binding 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0070410 co-SMAD binding 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0070679 inositol 1,4,5 trisphosphate binding 4/4869 12/18639 0.333333333333333 1.27603203943315 0.38619815502187 0.711556874663583 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 24/4869 86/18639 0.27906976744186 1.06830589347891 0.392623991081269 0.721929356093974 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 10/4869 34/18639 0.294117647058824 1.12591062302925 0.393386891864785 0.721929356093974 GO:0008171 O-methyltransferase activity 7/4869 23/18639 0.304347826086957 1.16507273165635 0.393974830760578 0.721929356093974 GO:0017134 fibroblast growth factor binding 7/4869 23/18639 0.304347826086957 1.16507273165635 0.393974830760578 0.721929356093974 GO:0004714 transmembrane receptor protein tyrosine kinase activity 17/4869 60/18639 0.283333333333333 1.08462723351818 0.395529377218713 0.722995930727533 GO:0005004 GPI-linked ephrin receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0005008 hepatocyte growth factor receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0005009 insulin receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0005011 macrophage colony-stimulating factor receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0005018 platelet-derived growth factor alpha-receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0005020 stem cell factor receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0008288 boss receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0036332 placental growth factor receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0038062 protein tyrosine kinase collagen receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0060175 brain-derived neurotrophic factor receptor activity 14/4869 49/18639 0.285714285714286 1.09374174808556 0.400469864975474 0.722995930727533 GO:0042562 hormone binding 26/4869 94/18639 0.276595744680851 1.05883509655091 0.405222274437567 0.729690336375872 GO:0000146 microfilament motor activity 11/4869 38/18639 0.289473684210526 1.10813308687616 0.405262960054109 0.729690336375872 GO:0004683 calcium/calmodulin-dependent protein kinase activity 8/4869 27/18639 0.296296296296296 1.13425070171835 0.409336610851996 0.730303891766221 GO:0003688 DNA replication origin binding 5/4869 16/18639 0.3125 1.19628003696858 0.410490514628449 0.730303891766221 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 5/4869 16/18639 0.3125 1.19628003696858 0.410490514628449 0.730303891766221 GO:0008296 3'-5'-DNA exonuclease activity 5/4869 16/18639 0.3125 1.19628003696858 0.410490514628449 0.730303891766221 GO:0015562 efflux transmembrane transporter activity 5/4869 16/18639 0.3125 1.19628003696858 0.410490514628449 0.730303891766221 GO:0017070 U6 snRNA binding 5/4869 16/18639 0.3125 1.19628003696858 0.410490514628449 0.730303891766221 GO:0022858 alanine transmembrane transporter activity 5/4869 16/18639 0.3125 1.19628003696858 0.410490514628449 0.730303891766221 GO:0031435 mitogen-activated protein kinase kinase kinase binding 5/4869 16/18639 0.3125 1.19628003696858 0.410490514628449 0.730303891766221 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 5/4869 16/18639 0.3125 1.19628003696858 0.410490514628449 0.730303891766221 GO:0001540 amyloid-beta binding 23/4869 83/18639 0.27710843373494 1.06079771952876 0.411501848622494 0.73113604543891 GO:0004857 enzyme inhibitor activity 111/4869 416/18639 0.266826923076923 1.02143910848855 0.414996440673818 0.735882641453486 GO:0004520 DNA endonuclease activity 12/4869 42/18639 0.285714285714286 1.09374174808556 0.415814726769256 0.735882641453486 GO:0031492 nucleosomal DNA binding 12/4869 42/18639 0.285714285714286 1.09374174808556 0.415814726769256 0.735882641453486 GO:0070279 vitamin B6 binding 16/4869 57/18639 0.280701754385965 1.07455329636476 0.417933816863478 0.738660950961075 GO:0017147 Wnt-protein binding 9/4869 31/18639 0.290322580645161 1.11138274402242 0.422291678673307 0.745383606057215 GO:0016836 hydro-lyase activity 17/4869 61/18639 0.278688524590164 1.06684645919821 0.425688605684871 0.750394724306883 GO:0016505 peptidase activator activity involved in apoptotic process 6/4869 20/18639 0.3 1.14842883548983 0.428494758978598 0.753366602387208 GO:0140939 histone H4 methyltransferase activity 6/4869 20/18639 0.3 1.14842883548983 0.428494758978598 0.753366602387208 GO:0005007 fibroblast growth factor receptor activity 14/4869 50/18639 0.28 1.07186691312384 0.433927462157676 0.759938068492285 GO:0005017 platelet-derived growth factor receptor activity 14/4869 50/18639 0.28 1.07186691312384 0.433927462157676 0.759938068492285 GO:0005019 platelet-derived growth factor beta-receptor activity 14/4869 50/18639 0.28 1.07186691312384 0.433927462157676 0.759938068492285 GO:0004622 lysophospholipase activity 7/4869 24/18639 0.291666666666667 1.116528034504 0.442747309057309 0.770368862460647 GO:0005315 phosphate transmembrane transporter activity 7/4869 24/18639 0.291666666666667 1.116528034504 0.442747309057309 0.770368862460647 GO:0030552 cAMP binding 7/4869 24/18639 0.291666666666667 1.116528034504 0.442747309057309 0.770368862460647 GO:0050699 WW domain binding 7/4869 24/18639 0.291666666666667 1.116528034504 0.442747309057309 0.770368862460647 GO:0070300 phosphatidic acid binding 7/4869 24/18639 0.291666666666667 1.116528034504 0.442747309057309 0.770368862460647 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 35/4869 130/18639 0.269230769230769 1.03064126261908 0.450731066809816 0.776807725155496 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0005338 nucleotide-sugar transmembrane transporter activity 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0008035 high-density lipoprotein particle binding 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0008417 fucosyltransferase activity 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0017154 semaphorin receptor activity 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0031432 titin binding 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0035673 oligopeptide transmembrane transporter activity 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0046974 histone H3K9 methyltransferase activity 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0070123 transforming growth factor beta receptor activity, type III 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/4869 13/18639 0.307692307692308 1.17787572870752 0.453378188550213 0.776807725155496 GO:0016866 intramolecular transferase activity 8/4869 28/18639 0.285714285714286 1.09374174808556 0.454533590853067 0.776807725155496 GO:0046625 sphingolipid binding 8/4869 28/18639 0.285714285714286 1.09374174808556 0.454533590853067 0.776807725155496 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 8/4869 28/18639 0.285714285714286 1.09374174808556 0.454533590853067 0.776807725155496 GO:0008201 heparin binding 46/4869 172/18639 0.267441860465116 1.02379314791729 0.455135272790093 0.776848911044004 GO:0071813 lipoprotein particle binding 9/4869 32/18639 0.28125 1.07665203327172 0.46458665003283 0.790973473790072 GO:0071814 protein-lipid complex binding 9/4869 32/18639 0.28125 1.07665203327172 0.46458665003283 0.790973473790072 GO:0005021 vascular endothelial growth factor receptor activity 14/4869 51/18639 0.274509803921569 1.0508499148273 0.467331890503151 0.791533932633132 GO:0004029 aldehyde dehydrogenase (NAD+) activity 5/4869 17/18639 0.294117647058824 1.12591062302925 0.469035348928332 0.791533932633132 GO:0004549 tRNA-specific ribonuclease activity 5/4869 17/18639 0.294117647058824 1.12591062302925 0.469035348928332 0.791533932633132 GO:0008429 phosphatidylethanolamine binding 5/4869 17/18639 0.294117647058824 1.12591062302925 0.469035348928332 0.791533932633132 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 5/4869 17/18639 0.294117647058824 1.12591062302925 0.469035348928332 0.791533932633132 GO:0017110 nucleoside diphosphate phosphatase activity 5/4869 17/18639 0.294117647058824 1.12591062302925 0.469035348928332 0.791533932633132 GO:0070492 oligosaccharide binding 5/4869 17/18639 0.294117647058824 1.12591062302925 0.469035348928332 0.791533932633132 GO:0004033 aldo-keto reductase (NADPH) activity 10/4869 36/18639 0.277777777777778 1.06336003286096 0.473360642922916 0.796833622942831 GO:0055106 ubiquitin-protein transferase regulator activity 10/4869 36/18639 0.277777777777778 1.06336003286096 0.473360642922916 0.796833622942831 GO:0140313 molecular sequestering activity 15/4869 55/18639 0.272727272727273 1.04402621408167 0.474010239243916 0.796929714728835 GO:0019199 transmembrane receptor protein kinase activity 21/4869 78/18639 0.269230769230769 1.03064126261908 0.479032363473477 0.804367701462955 GO:0000030 mannosyltransferase activity 7/4869 25/18639 0.28 1.07186691312384 0.490792283111562 0.820019404701927 GO:0003707 nuclear steroid receptor activity 7/4869 25/18639 0.28 1.07186691312384 0.490792283111562 0.820019404701927 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 7/4869 25/18639 0.28 1.07186691312384 0.490792283111562 0.820019404701927 GO:0047617 fatty acyl-CoA hydrolase activity 7/4869 25/18639 0.28 1.07186691312384 0.490792283111562 0.820019404701927 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 35/4869 132/18639 0.265151515151515 1.01502548591273 0.492313689176265 0.82003120251869 GO:0035250 UDP-galactosyltransferase activity 8/4869 29/18639 0.275862068965517 1.05602651539295 0.499056254870026 0.82003120251869 GO:0030170 pyridoxal phosphate binding 15/4869 56/18639 0.267857142857143 1.02538288883021 0.505905142629768 0.82003120251869 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 9/4869 33/18639 0.272727272727273 1.04402621408167 0.506250466251054 0.82003120251869 GO:0019239 deaminase activity 9/4869 33/18639 0.272727272727273 1.04402621408167 0.506250466251054 0.82003120251869 GO:0019956 chemokine binding 9/4869 33/18639 0.272727272727273 1.04402621408167 0.506250466251054 0.82003120251869 GO:0004090 carbonyl reductase (NADPH) activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0005131 growth hormone receptor binding 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0005381 iron ion transmembrane transporter activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0005522 profilin binding 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0008190 eukaryotic initiation factor 4E binding 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0008239 dipeptidyl-peptidase activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0015279 store-operated calcium channel activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0031419 cobalamin binding 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0031957 very long-chain fatty acid-CoA ligase activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0033204 ribonuclease P RNA binding 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0035256 G protein-coupled glutamate receptor binding 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0035374 chondroitin sulfate binding 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0140135 mechanosensitive monoatomic cation channel activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0140940 histone H2A methyltransferase activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:1905394 retromer complex binding 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:1990259 histone H2AQ104 methyltransferase activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:1990757 ubiquitin ligase activator activity 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:1990763 arrestin family protein binding 3/4869 10/18639 0.3 1.14842883548983 0.507870625797821 0.82003120251869 GO:0008081 phosphoric diester hydrolase activity 23/4869 87/18639 0.264367816091954 1.01202541058491 0.514367457467094 0.8295254559871 GO:0004065 arylsulfatase activity 4/4869 14/18639 0.285714285714286 1.09374174808556 0.51790110134945 0.830079400561552 GO:0015926 glucosidase activity 4/4869 14/18639 0.285714285714286 1.09374174808556 0.51790110134945 0.830079400561552 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 4/4869 14/18639 0.285714285714286 1.09374174808556 0.51790110134945 0.830079400561552 GO:0061665 SUMO ligase activity 4/4869 14/18639 0.285714285714286 1.09374174808556 0.51790110134945 0.830079400561552 GO:0071933 Arp2/3 complex binding 4/4869 14/18639 0.285714285714286 1.09374174808556 0.51790110134945 0.830079400561552 GO:0016877 ligase activity, forming carbon-sulfur bonds 11/4869 41/18639 0.268292682926829 1.02705017808034 0.518413900722456 0.830079400561552 GO:0031690 adrenergic receptor binding 5/4869 18/18639 0.277777777777778 1.06336003286096 0.525597137363279 0.840580439659466 GO:0030246 carbohydrate binding 73/4869 280/18639 0.260714285714286 0.99803934512807 0.530940581920133 0.844517614666762 GO:0008237 metallopeptidase activity 48/4869 184/18639 0.260869565217391 0.99863376999116 0.532779526527236 0.844517614666762 GO:0004864 protein phosphatase inhibitor activity 14/4869 53/18639 0.264150943396226 1.01119520106023 0.533082122566603 0.844517614666762 GO:0005003 ephrin receptor activity 14/4869 53/18639 0.264150943396226 1.01119520106023 0.533082122566603 0.844517614666762 GO:0005005 transmembrane-ephrin receptor activity 14/4869 53/18639 0.264150943396226 1.01119520106023 0.533082122566603 0.844517614666762 GO:0005246 calcium channel regulator activity 14/4869 53/18639 0.264150943396226 1.01119520106023 0.533082122566603 0.844517614666762 GO:0008146 sulfotransferase activity 14/4869 53/18639 0.264150943396226 1.01119520106023 0.533082122566603 0.844517614666762 GO:1901505 carbohydrate derivative transmembrane transporter activity 14/4869 53/18639 0.264150943396226 1.01119520106023 0.533082122566603 0.844517614666762 GO:0004112 cyclic-nucleotide phosphodiesterase activity 7/4869 26/18639 0.269230769230769 1.03064126261908 0.537496976465892 0.847567269110479 GO:0005227 calcium-activated cation channel activity 7/4869 26/18639 0.269230769230769 1.03064126261908 0.537496976465892 0.847567269110479 GO:0016289 acyl-CoA hydrolase activity 7/4869 26/18639 0.269230769230769 1.03064126261908 0.537496976465892 0.847567269110479 GO:0005539 glycosaminoglycan binding 63/4869 242/18639 0.260330578512397 0.996570477077955 0.537527792231404 0.847567269110479 GO:0022839 monoatomic ion-gated channel activity 8/4869 30/18639 0.266666666666667 1.02082563154652 0.542415448655152 0.853273425077403 GO:0031210 phosphatidylcholine binding 8/4869 30/18639 0.266666666666667 1.02082563154652 0.542415448655152 0.853273425077403 GO:0004896 cytokine receptor activity 25/4869 96/18639 0.260416666666667 0.996900030807147 0.546284940462022 0.857290699097317 GO:0016831 carboxy-lyase activity 9/4869 34/18639 0.264705882352941 1.01331956072632 0.54688135303011 0.857290699097317 GO:0090482 vitamin transmembrane transporter activity 9/4869 34/18639 0.264705882352941 1.01331956072632 0.54688135303011 0.857290699097317 GO:0042887 amide transmembrane transporter activity 10/4869 38/18639 0.263157894736842 1.00739371534196 0.550993477202098 0.862731346725055 GO:0004521 RNA endonuclease activity 19/4869 73/18639 0.26027397260274 0.996353784214924 0.552124027786142 0.863496299270188 GO:0070851 growth factor receptor binding 36/4869 139/18639 0.258992805755396 0.991449354379712 0.556482747875005 0.869302318109038 GO:0005200 structural constituent of cytoskeleton 29/4869 112/18639 0.258928571428571 0.991203459202535 0.558286933092575 0.87051592235587 GO:0015101 organic cation transmembrane transporter activity 21/4869 81/18639 0.259259259259259 0.99246936400356 0.558554082522763 0.87051592235587 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 14/4869 54/18639 0.259259259259259 0.99246936400356 0.565020932120725 0.876479479567369 GO:0008235 metalloexopeptidase activity 17/4869 66/18639 0.257575757575758 0.986024757743796 0.573855524167116 0.876479479567369 GO:0016782 transferase activity, transferring sulphur-containing groups 18/4869 70/18639 0.257142857142857 0.984367573277 0.576575067691622 0.876479479567369 GO:0004620 phospholipase activity 28/4869 109/18639 0.256880733944954 0.983364140480592 0.577767915571837 0.876479479567369 GO:0004467 long-chain fatty acid-CoA ligase activity 4/4869 15/18639 0.266666666666667 1.02082563154652 0.57857074831294 0.876479479567369 GO:0015929 hexosaminidase activity 4/4869 15/18639 0.266666666666667 1.02082563154652 0.57857074831294 0.876479479567369 GO:0034483 heparan sulfate sulfotransferase activity 4/4869 15/18639 0.266666666666667 1.02082563154652 0.57857074831294 0.876479479567369 GO:0047372 monoacylglycerol lipase activity 4/4869 15/18639 0.266666666666667 1.02082563154652 0.57857074831294 0.876479479567369 GO:0050780 dopamine receptor binding 4/4869 15/18639 0.266666666666667 1.02082563154652 0.57857074831294 0.876479479567369 GO:0000099 sulfur amino acid transmembrane transporter activity 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0005114 type II transforming growth factor beta receptor binding 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0008172 S-methyltransferase activity 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0010854 adenylate cyclase regulator activity 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0015217 ADP transmembrane transporter activity 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0016176 superoxide-generating NADPH oxidase activator activity 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0019206 nucleoside kinase activity 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0019215 intermediate filament binding 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0097493 structural molecule activity conferring elasticity 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0140031 phosphorylation-dependent protein binding 3/4869 11/18639 0.272727272727273 1.04402621408167 0.579071534265466 0.876479479567369 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 5/4869 19/18639 0.263157894736842 1.00739371534196 0.579323611401777 0.876479479567369 GO:0005229 intracellularly calcium-gated chloride channel activity 5/4869 19/18639 0.263157894736842 1.00739371534196 0.579323611401777 0.876479479567369 GO:0008574 plus-end-directed microtubule motor activity 5/4869 19/18639 0.263157894736842 1.00739371534196 0.579323611401777 0.876479479567369 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5/4869 19/18639 0.263157894736842 1.00739371534196 0.579323611401777 0.876479479567369 GO:0043395 heparan sulfate proteoglycan binding 5/4869 19/18639 0.263157894736842 1.00739371534196 0.579323611401777 0.876479479567369 GO:0141147 intracellularly calcium-gated channel activity 5/4869 19/18639 0.263157894736842 1.00739371534196 0.579323611401777 0.876479479567369 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 6/4869 23/18639 0.260869565217391 0.99863376999116 0.580680250454584 0.877544872877994 GO:0008320 protein transmembrane transporter activity 7/4869 27/18639 0.259259259259259 0.99246936400356 0.582353104430756 0.87908521375911 GO:0005164 tumor necrosis factor receptor binding 8/4869 31/18639 0.258064516129032 0.987895772464373 0.584197629518402 0.879894525982364 GO:0005452 solute:inorganic anion antiporter activity 8/4869 31/18639 0.258064516129032 0.987895772464373 0.584197629518402 0.879894525982364 GO:0140359 ABC-type transporter activity 12/4869 47/18639 0.25531914893617 0.977386242970071 0.59212507454137 0.890836941004634 GO:0030544 Hsp70 protein binding 13/4869 51/18639 0.254901960784314 0.975789206625349 0.594119661128139 0.892839043818265 GO:1901682 sulfur compound transmembrane transporter activity 16/4869 63/18639 0.253968253968254 0.972214887187161 0.599988298456486 0.900652077482113 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 31/4869 122/18639 0.254098360655738 0.972712948092482 0.605623837148419 0.908098172758778 GO:0015036 disulfide oxidoreductase activity 10/4869 40/18639 0.25 0.957024029574861 0.623772997038559 0.927233082788258 GO:0008378 galactosyltransferase activity 8/4869 32/18639 0.25 0.957024029574861 0.624067956013592 0.927233082788258 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/4869 32/18639 0.25 0.957024029574861 0.624067956013592 0.927233082788258 GO:0042910 xenobiotic transmembrane transporter activity 8/4869 32/18639 0.25 0.957024029574861 0.624067956013592 0.927233082788258 GO:0043425 bHLH transcription factor binding 8/4869 32/18639 0.25 0.957024029574861 0.624067956013592 0.927233082788258 GO:0016790 thiolester hydrolase activity 11/4869 44/18639 0.25 0.957024029574861 0.624102693266594 0.927233082788258 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 12/4869 48/18639 0.25 0.957024029574861 0.624642592454171 0.927233082788258 GO:0019212 phosphatase inhibitor activity 14/4869 56/18639 0.25 0.957024029574861 0.626161957894957 0.927233082788258 GO:0170055 lipid transmembrane transporter activity 14/4869 56/18639 0.25 0.957024029574861 0.626161957894957 0.927233082788258 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 6/4869 24/18639 0.25 0.957024029574861 0.626657897587008 0.927233082788258 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 6/4869 24/18639 0.25 0.957024029574861 0.626657897587008 0.927233082788258 GO:0019957 C-C chemokine binding 6/4869 24/18639 0.25 0.957024029574861 0.626657897587008 0.927233082788258 GO:0051536 iron-sulfur cluster binding 19/4869 76/18639 0.25 0.957024029574861 0.631326302838588 0.932459890748487 GO:0000062 fatty-acyl-CoA binding 4/4869 16/18639 0.25 0.957024029574861 0.634597492874437 0.932459890748487 GO:0005024 transforming growth factor beta receptor activity 4/4869 16/18639 0.25 0.957024029574861 0.634597492874437 0.932459890748487 GO:0043023 ribosomal large subunit binding 4/4869 16/18639 0.25 0.957024029574861 0.634597492874437 0.932459890748487 GO:0003720 telomerase activity 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0004126 cytidine deaminase activity 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0005025 transforming growth factor beta receptor activity, type I 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0005026 transforming growth factor beta receptor activity, type II 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0015269 calcium-activated potassium channel activity 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0015368 calcium:monoatomic cation antiporter activity 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0016361 activin receptor activity, type I 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0016362 activin receptor activity, type II 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0017002 activin receptor activity 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0035014 phosphatidylinositol 3-kinase regulator activity 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0036009 protein-glutamine N-methyltransferase activity 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0070008 serine-type exopeptidase activity 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0097677 STAT family protein binding 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:1990247 N6-methyladenosine-containing RNA reader activity 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:1990459 transferrin receptor binding 3/4869 12/18639 0.25 0.957024029574861 0.643362660679997 0.932459890748487 GO:0005544 calcium-dependent phospholipid binding 13/4869 53/18639 0.245283018867925 0.938966972413071 0.65532567989216 0.947755956403178 GO:0016251 RNA polymerase II general transcription initiation factor activity 13/4869 53/18639 0.245283018867925 0.938966972413071 0.65532567989216 0.947755956403178 GO:0051540 metal cluster binding 19/4869 77/18639 0.246753246753247 0.944595146073889 0.656196971979512 0.94799669958372 GO:0015175 neutral L-amino acid transmembrane transporter activity 10/4869 41/18639 0.24390243902439 0.933681980073035 0.657759802301818 0.949234907828268 GO:0003785 actin monomer binding 7/4869 29/18639 0.241379310344828 0.924023200968832 0.665019767075124 0.958683372686004 GO:0015296 monoatomic anion:monoatomic cation symporter activity 6/4869 25/18639 0.24 0.918743068391867 0.669562828473992 0.962138893480255 GO:0015662 P-type ion transporter activity 6/4869 25/18639 0.24 0.918743068391867 0.669562828473992 0.962138893480255 GO:0140358 P-type transmembrane transporter activity 6/4869 25/18639 0.24 0.918743068391867 0.669562828473992 0.962138893480255 GO:0009975 cyclase activity 5/4869 21/18639 0.238095238095238 0.911451456737963 0.676027623157121 0.967294843772689 GO:0015125 bile acid transmembrane transporter activity 5/4869 21/18639 0.238095238095238 0.911451456737963 0.676027623157121 0.967294843772689 GO:0036122 BMP binding 5/4869 21/18639 0.238095238095238 0.911451456737963 0.676027623157121 0.967294843772689 GO:1904047 S-adenosyl-L-methionine binding 5/4869 21/18639 0.238095238095238 0.911451456737963 0.676027623157121 0.967294843772689 GO:0016209 antioxidant activity 21/4869 86/18639 0.244186046511628 0.934767656794051 0.680146263759688 0.972153798891371 GO:0015179 L-amino acid transmembrane transporter activity 15/4869 62/18639 0.241935483870968 0.92615228668535 0.681852691913796 0.973558249070123 GO:0005092 GDP-dissociation inhibitor activity 4/4869 17/18639 0.235294117647059 0.900728498423399 0.6855396910117 0.973654576991274 GO:0015278 intracellularly gated calcium channel activity 4/4869 17/18639 0.235294117647059 0.900728498423399 0.6855396910117 0.973654576991274 GO:0015347 sodium-independent organic anion transmembrane transporter activity 4/4869 17/18639 0.235294117647059 0.900728498423399 0.6855396910117 0.973654576991274 GO:0030169 low-density lipoprotein particle binding 4/4869 17/18639 0.235294117647059 0.900728498423399 0.6855396910117 0.973654576991274 GO:1901567 fatty acid derivative binding 4/4869 17/18639 0.235294117647059 0.900728498423399 0.6855396910117 0.973654576991274 GO:0048487 beta-tubulin binding 10/4869 42/18639 0.238095238095238 0.911451456737963 0.689928472014268 0.978854213986488 GO:0003964 RNA-directed DNA polymerase activity 3/4869 13/18639 0.230769230769231 0.883406796530641 0.700358002318932 0.984306701273734 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3/4869 13/18639 0.230769230769231 0.883406796530641 0.700358002318932 0.984306701273734 GO:0005035 death receptor activity 3/4869 13/18639 0.230769230769231 0.883406796530641 0.700358002318932 0.984306701273734 GO:0009982 pseudouridine synthase activity 3/4869 13/18639 0.230769230769231 0.883406796530641 0.700358002318932 0.984306701273734 GO:0019104 DNA N-glycosylase activity 3/4869 13/18639 0.230769230769231 0.883406796530641 0.700358002318932 0.984306701273734 GO:0030955 potassium ion binding 3/4869 13/18639 0.230769230769231 0.883406796530641 0.700358002318932 0.984306701273734 GO:0061459 L-arginine transmembrane transporter activity 3/4869 13/18639 0.230769230769231 0.883406796530641 0.700358002318932 0.984306701273734 GO:0070700 BMP receptor binding 3/4869 13/18639 0.230769230769231 0.883406796530641 0.700358002318932 0.984306701273734 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 3/4869 13/18639 0.230769230769231 0.883406796530641 0.700358002318932 0.984306701273734 GO:0016500 protein-hormone receptor activity 16/4869 67/18639 0.238805970149254 0.914172207355092 0.706041388179828 0.991258525158527 GO:0016597 amino acid binding 12/4869 51/18639 0.235294117647059 0.900728498423399 0.713606976084034 1 GO:0015377 chloride:monoatomic cation symporter activity 5/4869 22/18639 0.227272727272727 0.870021845068056 0.718396192087075 1 GO:0030021 extracellular matrix structural constituent conferring compression resistance 5/4869 22/18639 0.227272727272727 0.870021845068056 0.718396192087075 1 GO:0016229 steroid dehydrogenase activity 8/4869 35/18639 0.228571428571429 0.874993398468445 0.730004226026011 1 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/4869 18/18639 0.222222222222222 0.850688026288766 0.731237563482677 1 GO:0008308 voltage-gated monoatomic anion channel activity 4/4869 18/18639 0.222222222222222 0.850688026288766 0.731237563482677 1 GO:0015172 acidic amino acid transmembrane transporter activity 4/4869 18/18639 0.222222222222222 0.850688026288766 0.731237563482677 1 GO:0099602 neurotransmitter receptor regulator activity 4/4869 18/18639 0.222222222222222 0.850688026288766 0.731237563482677 1 GO:1901611 phosphatidylglycerol binding 4/4869 18/18639 0.222222222222222 0.850688026288766 0.731237563482677 1 GO:0016878 acid-thiol ligase activity 7/4869 31/18639 0.225806451612903 0.864408800906326 0.736790602661657 1 GO:0004364 glutathione transferase activity 6/4869 27/18639 0.222222222222222 0.850688026288766 0.745419578260898 1 GO:0005044 scavenger receptor activity 6/4869 27/18639 0.222222222222222 0.850688026288766 0.745419578260898 1 GO:0016405 CoA-ligase activity 6/4869 27/18639 0.222222222222222 0.850688026288766 0.745419578260898 1 GO:0005313 L-glutamate transmembrane transporter activity 3/4869 14/18639 0.214285714285714 0.820306311064167 0.750118975310609 1 GO:0008494 translation activator activity 3/4869 14/18639 0.214285714285714 0.820306311064167 0.750118975310609 1 GO:0016530 metallochaperone activity 3/4869 14/18639 0.214285714285714 0.820306311064167 0.750118975310609 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters 3/4869 14/18639 0.214285714285714 0.820306311064167 0.750118975310609 1 GO:0019992 diacylglycerol binding 3/4869 14/18639 0.214285714285714 0.820306311064167 0.750118975310609 1 GO:0031404 chloride ion binding 3/4869 14/18639 0.214285714285714 0.820306311064167 0.750118975310609 1 GO:0098821 BMP receptor activity 3/4869 14/18639 0.214285714285714 0.820306311064167 0.750118975310609 1 GO:1901474 azole transmembrane transporter activity 3/4869 14/18639 0.214285714285714 0.820306311064167 0.750118975310609 1 GO:0005506 iron ion binding 37/4869 154/18639 0.24025974025974 0.919737379071945 0.751427529118397 1 GO:0016298 lipase activity 31/4869 130/18639 0.238461538461538 0.912853689748329 0.75321477022288 1 GO:0004022 alcohol dehydrogenase (NAD+) activity 5/4869 23/18639 0.217391304347826 0.832194808325966 0.756650620318322 1 GO:0004602 glutathione peroxidase activity 5/4869 23/18639 0.217391304347826 0.832194808325966 0.756650620318322 1 GO:0016849 phosphorus-oxygen lyase activity 5/4869 23/18639 0.217391304347826 0.832194808325966 0.756650620318322 1 GO:0099186 structural constituent of postsynapse 5/4869 23/18639 0.217391304347826 0.832194808325966 0.756650620318322 1 GO:0140103 catalytic activity, acting on a glycoprotein 5/4869 23/18639 0.217391304347826 0.832194808325966 0.756650620318322 1 GO:0004497 monooxygenase activity 25/4869 106/18639 0.235849056603774 0.902852858089492 0.757492367784855 1 GO:0015026 coreceptor activity 14/4869 61/18639 0.229508196721311 0.878579436986758 0.75763729228869 1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 14/4869 61/18639 0.229508196721311 0.878579436986758 0.75763729228869 1 GO:0008238 exopeptidase activity 24/4869 102/18639 0.235294117647059 0.900728498423399 0.758558333553898 1 GO:0022884 macromolecule transmembrane transporter activity 7/4869 32/18639 0.21875 0.837396025878004 0.768352943723115 1 GO:0008301 DNA binding, bending 4/4869 19/18639 0.210526315789474 0.805914972273567 0.771747950704251 1 GO:0008381 mechanosensitive monoatomic ion channel activity 4/4869 19/18639 0.210526315789474 0.805914972273567 0.771747950704251 1 GO:0016918 retinal binding 4/4869 19/18639 0.210526315789474 0.805914972273567 0.771747950704251 1 GO:0030506 ankyrin binding 4/4869 19/18639 0.210526315789474 0.805914972273567 0.771747950704251 1 GO:0070003 threonine-type peptidase activity 4/4869 19/18639 0.210526315789474 0.805914972273567 0.771747950704251 1 GO:0120227 acyl-CoA binding 4/4869 19/18639 0.210526315789474 0.805914972273567 0.771747950704251 1 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/4869 10/18639 0.2 0.765619223659889 0.780400258804552 1 GO:0005345 purine nucleobase transmembrane transporter activity 2/4869 10/18639 0.2 0.765619223659889 0.780400258804552 1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/4869 10/18639 0.2 0.765619223659889 0.780400258804552 1 GO:0008519 ammonium channel activity 2/4869 10/18639 0.2 0.765619223659889 0.780400258804552 1 GO:0031996 thioesterase binding 2/4869 10/18639 0.2 0.765619223659889 0.780400258804552 1 GO:0032356 oxidized DNA binding 2/4869 10/18639 0.2 0.765619223659889 0.780400258804552 1 GO:0043295 glutathione binding 2/4869 10/18639 0.2 0.765619223659889 0.780400258804552 1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/4869 10/18639 0.2 0.765619223659889 0.780400258804552 1 GO:0051880 G-quadruplex DNA binding 2/4869 10/18639 0.2 0.765619223659889 0.780400258804552 1 GO:0030551 cyclic nucleotide binding 8/4869 37/18639 0.216216216216216 0.827696458010691 0.788214419982051 1 GO:0043394 proteoglycan binding 8/4869 37/18639 0.216216216216216 0.827696458010691 0.788214419982051 1 GO:0140612 DNA damage sensor activity 5/4869 24/18639 0.208333333333333 0.797520024645718 0.790859231563404 1 GO:0004089 carbonate dehydratase activity 3/4869 15/18639 0.2 0.765619223659889 0.793006032060026 1 GO:0004559 alpha-mannosidase activity 3/4869 15/18639 0.2 0.765619223659889 0.793006032060026 1 GO:0005041 low-density lipoprotein particle receptor activity 3/4869 15/18639 0.2 0.765619223659889 0.793006032060026 1 GO:0017081 chloride channel regulator activity 3/4869 15/18639 0.2 0.765619223659889 0.793006032060026 1 GO:0030553 cGMP binding 3/4869 15/18639 0.2 0.765619223659889 0.793006032060026 1 GO:0140161 monocarboxylate:sodium symporter activity 3/4869 15/18639 0.2 0.765619223659889 0.793006032060026 1 GO:0032813 tumor necrosis factor receptor superfamily binding 11/4869 50/18639 0.22 0.842181146025878 0.793072276336347 1 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 4/4869 20/18639 0.2 0.765619223659889 0.807284964494604 1 GO:0010851 cyclase regulator activity 4/4869 20/18639 0.2 0.765619223659889 0.807284964494604 1 GO:0016408 C-acyltransferase activity 4/4869 20/18639 0.2 0.765619223659889 0.807284964494604 1 GO:0015291 secondary active transmembrane transporter activity 69/4869 287/18639 0.240418118466899 0.920343666071992 0.808938007966469 1 GO:0005109 frizzled binding 8/4869 38/18639 0.210526315789474 0.805914972273567 0.813582438541116 1 GO:0005537 D-mannose binding 5/4869 25/18639 0.2 0.765619223659889 0.821183332335758 1 GO:0015645 fatty acid ligase activity 5/4869 25/18639 0.2 0.765619223659889 0.821183332335758 1 GO:0120515 fatty acid-CoA ligase activity 5/4869 25/18639 0.2 0.765619223659889 0.821183332335758 1 GO:0015035 protein-disulfide reductase activity 7/4869 34/18639 0.205882352941176 0.788137436120474 0.822955913851739 1 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 7/4869 34/18639 0.205882352941176 0.788137436120474 0.822955913851739 1 GO:0004016 adenylate cyclase activity 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0008046 axon guidance receptor activity 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0008199 ferric iron binding 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0015205 nucleobase transmembrane transporter activity 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0019203 carbohydrate phosphatase activity 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0032404 mismatch repair complex binding 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0032794 GTPase activating protein binding 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0048407 platelet-derived growth factor binding 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0050786 RAGE receptor binding 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:1900750 oligopeptide binding 2/4869 11/18639 0.181818181818182 0.696017476054445 0.825139975368793 1 GO:0042626 ATPase-coupled transmembrane transporter activity 22/4869 98/18639 0.224489795918367 0.859368516352937 0.827311083783791 1 GO:0046982 protein heterodimerization activity 89/4869 369/18639 0.241192411924119 0.923307735850002 0.827353047448168 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 9/4869 43/18639 0.209302325581395 0.801229420109186 0.828290220810976 1 GO:0004175 endopeptidase activity 98/4869 405/18639 0.241975308641975 0.926304739736656 0.828439569540286 1 GO:0016247 channel regulator activity 39/4869 168/18639 0.232142857142857 0.888665170319514 0.828693750517884 1 GO:0015923 mannosidase activity 3/4869 16/18639 0.1875 0.717768022181146 0.829561848795162 1 GO:0016722 oxidoreductase activity, acting on metal ions 3/4869 16/18639 0.1875 0.717768022181146 0.829561848795162 1 GO:0019841 retinol binding 3/4869 16/18639 0.1875 0.717768022181146 0.829561848795162 1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 3/4869 16/18639 0.1875 0.717768022181146 0.829561848795162 1 GO:0099106 ion channel regulator activity 37/4869 160/18639 0.23125 0.885247227356747 0.830518471972817 1 GO:0048019 receptor antagonist activity 6/4869 30/18639 0.2 0.765619223659889 0.834187013093225 1 GO:0098918 structural constituent of synapse 6/4869 30/18639 0.2 0.765619223659889 0.834187013093225 1 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 11/4869 52/18639 0.211538461538462 0.809789563486421 0.835003879555447 1 GO:0000217 DNA secondary structure binding 8/4869 39/18639 0.205128205128205 0.785250485805014 0.836552327170168 1 GO:0019843 rRNA binding 14/4869 65/18639 0.215384615384615 0.824513010095265 0.837448347556311 1 GO:0038024 cargo receptor activity 14/4869 65/18639 0.215384615384615 0.824513010095265 0.837448347556311 1 GO:0005123 death receptor binding 4/4869 21/18639 0.19047619047619 0.729161165390371 0.838169044809306 1 GO:0015174 basic amino acid transmembrane transporter activity 4/4869 21/18639 0.19047619047619 0.729161165390371 0.838169044809306 1 GO:0051428 peptide hormone receptor binding 4/4869 21/18639 0.19047619047619 0.729161165390371 0.838169044809306 1 GO:0061891 calcium ion sensor activity 4/4869 21/18639 0.19047619047619 0.729161165390371 0.838169044809306 1 GO:0005343 organic acid:sodium symporter activity 7/4869 35/18639 0.2 0.765619223659889 0.846193835808171 1 GO:0030547 signaling receptor inhibitor activity 9/4869 44/18639 0.204545454545455 0.78301966056125 0.848825917935241 1 GO:0141108 transporter regulator activity 39/4869 170/18639 0.229411764705882 0.878210285962814 0.850282560198386 1 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8/4869 40/18639 0.2 0.765619223659889 0.857230668391787 1 GO:0005310 dicarboxylic acid transmembrane transporter activity 6/4869 31/18639 0.193548387096774 0.74092182934828 0.857562151596802 1 GO:0008327 methyl-CpG binding 6/4869 31/18639 0.193548387096774 0.74092182934828 0.857562151596802 1 GO:0047499 calcium-independent phospholipase A2 activity 6/4869 31/18639 0.193548387096774 0.74092182934828 0.857562151596802 1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3/4869 17/18639 0.176470588235294 0.675546373817549 0.860423739748761 1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/4869 17/18639 0.176470588235294 0.675546373817549 0.860423739748761 1 GO:0030548 acetylcholine receptor regulator activity 3/4869 17/18639 0.176470588235294 0.675546373817549 0.860423739748761 1 GO:0051787 misfolded protein binding 3/4869 17/18639 0.176470588235294 0.675546373817549 0.860423739748761 1 GO:0004032 aldose reductase (NADPH) activity 2/4869 12/18639 0.166666666666667 0.638016019716574 0.861495438306552 1 GO:0005165 neurotrophin receptor binding 2/4869 12/18639 0.166666666666667 0.638016019716574 0.861495438306552 1 GO:0005247 voltage-gated chloride channel activity 2/4869 12/18639 0.166666666666667 0.638016019716574 0.861495438306552 1 GO:0005436 sodium:phosphate symporter activity 2/4869 12/18639 0.166666666666667 0.638016019716574 0.861495438306552 1 GO:0008179 adenylate cyclase binding 2/4869 12/18639 0.166666666666667 0.638016019716574 0.861495438306552 1 GO:0015166 polyol transmembrane transporter activity 2/4869 12/18639 0.166666666666667 0.638016019716574 0.861495438306552 1 GO:0016840 carbon-nitrogen lyase activity 2/4869 12/18639 0.166666666666667 0.638016019716574 0.861495438306552 1 GO:0097371 MDM2/MDM4 family protein binding 2/4869 12/18639 0.166666666666667 0.638016019716574 0.861495438306552 1 GO:0016798 hydrolase activity, acting on glycosyl bonds 29/4869 130/18639 0.223076923076923 0.853959903312953 0.863799106627958 1 GO:0033691 sialic acid binding 4/4869 22/18639 0.181818181818182 0.696017476054445 0.864785234303135 1 GO:0140784 metal ion sensor activity 4/4869 22/18639 0.181818181818182 0.696017476054445 0.864785234303135 1 GO:0008395 steroid hydroxylase activity 5/4869 27/18639 0.185185185185185 0.708906688573971 0.871129858727253 1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 5/4869 27/18639 0.185185185185185 0.708906688573971 0.871129858727253 1 GO:0061134 peptidase regulator activity 52/4869 226/18639 0.230088495575221 0.880800876776863 0.875450584968234 1 GO:0140318 protein transporter activity 8/4869 41/18639 0.195121951219512 0.746945584058428 0.875744472601045 1 GO:0048020 CCR chemokine receptor binding 10/4869 50/18639 0.2 0.765619223659889 0.8766747929565 1 GO:0047498 calcium-dependent phospholipase A2 activity 6/4869 32/18639 0.1875 0.717768022181146 0.878148891875345 1 GO:0001786 phosphatidylserine binding 12/4869 59/18639 0.203389830508475 0.778595820671074 0.879329876587798 1 GO:0015459 potassium channel regulator activity 12/4869 59/18639 0.203389830508475 0.778595820671074 0.879329876587798 1 GO:0036002 pre-mRNA binding 12/4869 59/18639 0.203389830508475 0.778595820671074 0.879329876587798 1 GO:0004180 carboxypeptidase activity 9/4869 46/18639 0.195652173913043 0.74897532749337 0.884019493630158 1 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 9/4869 46/18639 0.195652173913043 0.74897532749337 0.884019493630158 1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 3/4869 18/18639 0.166666666666667 0.638016019716574 0.886260975001978 1 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 3/4869 18/18639 0.166666666666667 0.638016019716574 0.886260975001978 1 GO:0030228 lipoprotein particle receptor activity 3/4869 18/18639 0.166666666666667 0.638016019716574 0.886260975001978 1 GO:0034185 apolipoprotein binding 3/4869 18/18639 0.166666666666667 0.638016019716574 0.886260975001978 1 GO:0016493 C-C chemokine receptor activity 4/4869 23/18639 0.173913043478261 0.665755846660773 0.887550416194675 1 GO:0002161 aminoacyl-tRNA editing activity 2/4869 13/18639 0.153846153846154 0.588937864353761 0.890793153940665 1 GO:0015651 quaternary ammonium group transmembrane transporter activity 2/4869 13/18639 0.153846153846154 0.588937864353761 0.890793153940665 1 GO:0071837 HMG box domain binding 2/4869 13/18639 0.153846153846154 0.588937864353761 0.890793153940665 1 GO:1901338 catecholamine binding 2/4869 13/18639 0.153846153846154 0.588937864353761 0.890793153940665 1 GO:0031406 carboxylic acid binding 42/4869 187/18639 0.224598930481283 0.859786293949608 0.891984817896001 1 GO:0030296 protein tyrosine kinase activator activity 6/4869 33/18639 0.181818181818182 0.696017476054445 0.896171207388673 1 GO:0005501 retinoid binding 7/4869 38/18639 0.184210526315789 0.705175600739372 0.901460451373078 1 GO:0019840 isoprenoid binding 7/4869 38/18639 0.184210526315789 0.705175600739372 0.901460451373078 1 GO:0016853 isomerase activity 40/4869 180/18639 0.222222222222222 0.850688026288766 0.901815307036943 1 GO:0015085 calcium ion transmembrane transporter activity 32/4869 147/18639 0.217687074829932 0.833327046160423 0.905307862957452 1 GO:0043177 organic acid binding 42/4869 189/18639 0.222222222222222 0.850688026288766 0.906677771148557 1 GO:0005245 voltage-gated calcium channel activity 8/4869 43/18639 0.186046511627907 0.712203928985943 0.906850563070354 1 GO:0004806 triacylglycerol lipase activity 4/4869 24/18639 0.166666666666667 0.638016019716574 0.906888653120929 1 GO:0048027 mRNA 5'-UTR binding 4/4869 24/18639 0.166666666666667 0.638016019716574 0.906888653120929 1 GO:0060229 lipase activator activity 4/4869 24/18639 0.166666666666667 0.638016019716574 0.906888653120929 1 GO:0033218 amide binding 56/4869 247/18639 0.226720647773279 0.867908431679227 0.907383501449342 1 GO:0003756 protein disulfide isomerase activity 3/4869 19/18639 0.157894736842105 0.604436229205176 0.907732167057802 1 GO:0015245 fatty acid transmembrane transporter activity 3/4869 19/18639 0.157894736842105 0.604436229205176 0.907732167057802 1 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3/4869 19/18639 0.157894736842105 0.604436229205176 0.907732167057802 1 GO:0034987 immunoglobulin receptor binding 3/4869 19/18639 0.157894736842105 0.604436229205176 0.907732167057802 1 GO:0042834 peptidoglycan binding 3/4869 19/18639 0.157894736842105 0.604436229205176 0.907732167057802 1 GO:0052689 carboxylic ester hydrolase activity 19/4869 92/18639 0.206521739130435 0.790585067909668 0.908687773598893 1 GO:0051861 glycolipid binding 5/4869 29/18639 0.172413793103448 0.660016572120594 0.90871208717715 1 GO:0033293 monocarboxylic acid binding 16/4869 79/18639 0.20253164556962 0.775310606237862 0.909304369177523 1 GO:0140375 immune receptor activity 34/4869 156/18639 0.217948717948718 0.834328641167828 0.909815351696499 1 GO:0051427 hormone receptor binding 6/4869 34/18639 0.176470588235294 0.675546373817549 0.911860198860873 1 GO:0038187 pattern recognition receptor activity 9/4869 48/18639 0.1875 0.717768022181146 0.912164612433129 1 GO:0008331 high voltage-gated calcium channel activity 2/4869 14/18639 0.142857142857143 0.546870874042778 0.914238850379008 1 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 2/4869 14/18639 0.142857142857143 0.546870874042778 0.914238850379008 1 GO:0043176 amine binding 2/4869 14/18639 0.142857142857143 0.546870874042778 0.914238850379008 1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 2/4869 14/18639 0.142857142857143 0.546870874042778 0.914238850379008 1 GO:1901612 cardiolipin binding 2/4869 14/18639 0.142857142857143 0.546870874042778 0.914238850379008 1 GO:0017046 peptide hormone binding 10/4869 53/18639 0.188679245283019 0.722282286471594 0.917307746442976 1 GO:0030020 extracellular matrix structural constituent conferring tensile strength 8/4869 44/18639 0.181818181818182 0.696017476054445 0.919744928655934 1 GO:0008083 growth factor activity 35/4869 162/18639 0.216049382716049 0.8270578033363 0.922205633721561 1 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 5/4869 30/18639 0.166666666666667 0.638016019716574 0.923617101993935 1 GO:0004623 phospholipase A2 activity 6/4869 35/18639 0.171428571428571 0.656245048851334 0.925446342940743 1 GO:0001972 retinoic acid binding 3/4869 20/18639 0.15 0.574214417744917 0.925458143980719 1 GO:0005326 neurotransmitter transmembrane transporter activity 3/4869 20/18639 0.15 0.574214417744917 0.925458143980719 1 GO:0016004 phospholipase activator activity 3/4869 20/18639 0.15 0.574214417744917 0.925458143980719 1 GO:0140664 ATP-dependent DNA damage sensor activity 3/4869 20/18639 0.15 0.574214417744917 0.925458143980719 1 GO:0005507 copper ion binding 12/4869 63/18639 0.19047619047619 0.729161165390371 0.926909240679093 1 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 11/4869 59/18639 0.186440677966102 0.713712835615151 0.93206184545838 1 GO:0004865 protein serine/threonine phosphatase inhibitor activity 2/4869 15/18639 0.133333333333333 0.510412815773259 0.932890053197313 1 GO:0005402 carbohydrate:monoatomic cation symporter activity 2/4869 15/18639 0.133333333333333 0.510412815773259 0.932890053197313 1 GO:0008242 omega peptidase activity 2/4869 15/18639 0.133333333333333 0.510412815773259 0.932890053197313 1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 2/4869 15/18639 0.133333333333333 0.510412815773259 0.932890053197313 1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/4869 15/18639 0.133333333333333 0.510412815773259 0.932890053197313 1 GO:0001637 G protein-coupled chemoattractant receptor activity 4/4869 26/18639 0.153846153846154 0.588937864353761 0.93691589412185 1 GO:0004950 chemokine receptor activity 4/4869 26/18639 0.153846153846154 0.588937864353761 0.93691589412185 1 GO:0019865 immunoglobulin binding 4/4869 26/18639 0.153846153846154 0.588937864353761 0.93691589412185 1 GO:0004190 aspartic-type endopeptidase activity 6/4869 36/18639 0.166666666666667 0.638016019716574 0.937153596225076 1 GO:0004812 aminoacyl-tRNA ligase activity 7/4869 41/18639 0.170731707317073 0.653577386051125 0.938822419617075 1 GO:0016875 ligase activity, forming carbon-oxygen bonds 7/4869 41/18639 0.170731707317073 0.653577386051125 0.938822419617075 1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3/4869 21/18639 0.142857142857143 0.546870874042778 0.940006327175955 1 GO:0016651 oxidoreductase activity, acting on NAD(P)H 17/4869 88/18639 0.193181818181818 0.739518568307847 0.946602539538773 1 GO:0008028 monocarboxylic acid transmembrane transporter activity 13/4869 70/18639 0.185714285714286 0.710932136255611 0.94706170442167 1 GO:0070001 aspartic-type peptidase activity 6/4869 37/18639 0.162162162162162 0.620772343508018 0.947195118776178 1 GO:0005324 long-chain fatty acid transmembrane transporter activity 2/4869 16/18639 0.125 0.478512014787431 0.947651225254763 1 GO:0015378 sodium:chloride symporter activity 2/4869 16/18639 0.125 0.478512014787431 0.947651225254763 1 GO:0061135 endopeptidase regulator activity 39/4869 184/18639 0.21195652173913 0.811389938117817 0.949217860935504 1 GO:0005504 fatty acid binding 8/4869 47/18639 0.170212765957447 0.651590828646714 0.949604521062541 1 GO:0004935 adrenergic receptor activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0004955 prostaglandin receptor activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0005031 tumor necrosis factor receptor activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0005337 nucleoside transmembrane transporter activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0015187 glycine transmembrane transporter activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0016175 superoxide-generating NAD(P)H oxidase activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0016783 sulfurtransferase activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0019911 structural constituent of myelin sheath 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0032052 bile acid binding 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0043208 glycosphingolipid binding 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0047429 nucleoside triphosphate diphosphatase activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0050308 sugar-phosphatase activity 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0051378 serotonin binding 1/4869 10/18639 0.1 0.382809611829945 0.951611470775639 1 GO:0015293 symporter activity 30/4869 146/18639 0.205479452054795 0.786595092801256 0.951815811267366 1 GO:0005243 gap junction channel activity 3/4869 22/18639 0.136363636363636 0.522013107040833 0.951883341840084 1 GO:0008970 phospholipase A1 activity 3/4869 22/18639 0.136363636363636 0.522013107040833 0.951883341840084 1 GO:0140517 protein-RNA adaptor activity 3/4869 22/18639 0.136363636363636 0.522013107040833 0.951883341840084 1 GO:0004601 peroxidase activity 10/4869 57/18639 0.175438596491228 0.671595810227973 0.953344048862104 1 GO:0140299 molecular sensor activity 13/4869 71/18639 0.183098591549296 0.700919007575955 0.953677484988823 1 GO:0051537 2 iron, 2 sulfur cluster binding 4/4869 28/18639 0.142857142857143 0.546870874042778 0.95786372018923 1 GO:0016860 intramolecular oxidoreductase activity 9/4869 53/18639 0.169811320754717 0.650054057824434 0.958353907795901 1 GO:0009881 photoreceptor activity 2/4869 17/18639 0.117647058823529 0.450364249211699 0.959281556655563 1 GO:0016018 cyclosporin A binding 2/4869 17/18639 0.117647058823529 0.450364249211699 0.959281556655563 1 GO:0032977 membrane insertase activity 2/4869 17/18639 0.117647058823529 0.450364249211699 0.959281556655563 1 GO:0036041 long-chain fatty acid binding 2/4869 17/18639 0.117647058823529 0.450364249211699 0.959281556655563 1 GO:0045125 bioactive lipid receptor activity 2/4869 17/18639 0.117647058823529 0.450364249211699 0.959281556655563 1 GO:0045236 CXCR chemokine receptor binding 2/4869 17/18639 0.117647058823529 0.450364249211699 0.959281556655563 1 GO:0001664 G protein-coupled receptor binding 65/4869 297/18639 0.218855218855219 0.837798813769239 0.96125740136329 1 GO:0005212 structural constituent of eye lens 3/4869 23/18639 0.130434782608696 0.49931688499558 0.961533280686895 1 GO:0005283 amino acid:sodium symporter activity 3/4869 23/18639 0.130434782608696 0.49931688499558 0.961533280686895 1 GO:0015020 glucuronosyltransferase activity 5/4869 34/18639 0.147058823529412 0.562955311514624 0.963827758607166 1 GO:0001851 complement component C3b binding 1/4869 11/18639 0.0909090909090909 0.348008738027222 0.964258620316324 1 GO:0004954 prostanoid receptor activity 1/4869 11/18639 0.0909090909090909 0.348008738027222 0.964258620316324 1 GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity 1/4869 11/18639 0.0909090909090909 0.348008738027222 0.964258620316324 1 GO:0008503 benzodiazepine receptor activity 1/4869 11/18639 0.0909090909090909 0.348008738027222 0.964258620316324 1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/4869 11/18639 0.0909090909090909 0.348008738027222 0.964258620316324 1 GO:0043855 cyclic nucleotide-activated monoatomic ion channel activity 1/4869 11/18639 0.0909090909090909 0.348008738027222 0.964258620316324 1 GO:0099528 G protein-coupled neurotransmitter receptor activity 1/4869 11/18639 0.0909090909090909 0.348008738027222 0.964258620316324 1 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 9/4869 54/18639 0.166666666666667 0.638016019716574 0.964416531391406 1 GO:0004181 metallocarboxypeptidase activity 4/4869 29/18639 0.137931034482759 0.528013257696475 0.965727981471163 1 GO:0099604 ligand-gated calcium channel activity 4/4869 29/18639 0.137931034482759 0.528013257696475 0.965727981471163 1 GO:0000400 four-way junction DNA binding 2/4869 18/18639 0.111111111111111 0.425344013144383 0.968409129362261 1 GO:0015280 ligand-gated sodium channel activity 2/4869 18/18639 0.111111111111111 0.425344013144383 0.968409129362261 1 GO:0015373 monoatomic anion:sodium symporter activity 2/4869 18/18639 0.111111111111111 0.425344013144383 0.968409129362261 1 GO:0016854 racemase and epimerase activity 2/4869 18/18639 0.111111111111111 0.425344013144383 0.968409129362261 1 GO:0050811 GABA receptor binding 2/4869 18/18639 0.111111111111111 0.425344013144383 0.968409129362261 1 GO:0008009 chemokine activity 7/4869 45/18639 0.155555555555556 0.595481618402136 0.968952132361631 1 GO:0005540 hyaluronic acid binding 3/4869 24/18639 0.125 0.478512014787431 0.969339656053462 1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/4869 24/18639 0.125 0.478512014787431 0.969339656053462 1 GO:0042625 ATPase-coupled ion transmembrane transporter activity 3/4869 24/18639 0.125 0.478512014787431 0.969339656053462 1 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 3/4869 24/18639 0.125 0.478512014787431 0.969339656053462 1 GO:0046961 proton-transporting ATPase activity, rotational mechanism 3/4869 24/18639 0.125 0.478512014787431 0.969339656053462 1 GO:0015370 solute:sodium symporter activity 14/4869 79/18639 0.177215189873418 0.67839678045813 0.970738546290336 1 GO:0046906 tetrapyrrole binding 30/4869 152/18639 0.197368421052632 0.755545286506469 0.973590652807375 1 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 1/4869 12/18639 0.0833333333333333 0.319008009858287 0.973600727771757 1 GO:0010853 cyclase activator activity 1/4869 12/18639 0.0833333333333333 0.319008009858287 0.973600727771757 1 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/4869 12/18639 0.0833333333333333 0.319008009858287 0.973600727771757 1 GO:0001530 lipopolysaccharide binding 6/4869 41/18639 0.146341463414634 0.560209188043821 0.974456336138242 1 GO:0022840 leak channel activity 2/4869 19/18639 0.105263157894737 0.402957486136784 0.975547595515727 1 GO:0022842 narrow pore channel activity 2/4869 19/18639 0.105263157894737 0.402957486136784 0.975547595515727 1 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 5/4869 36/18639 0.138888888888889 0.531680016430479 0.97555870395907 1 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 5/4869 36/18639 0.138888888888889 0.531680016430479 0.97555870395907 1 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 5/4869 36/18639 0.138888888888889 0.531680016430479 0.97555870395907 1 GO:0001848 complement binding 3/4869 25/18639 0.12 0.459371534195933 0.975629589679712 1 GO:0015271 outward rectifier potassium channel activity 3/4869 25/18639 0.12 0.459371534195933 0.975629589679712 1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/4869 25/18639 0.12 0.459371534195933 0.975629589679712 1 GO:0005262 calcium channel activity 25/4869 131/18639 0.190839694656489 0.730552694331955 0.97682150547588 1 GO:0004867 serine-type endopeptidase inhibitor activity 17/4869 95/18639 0.178947368421053 0.685027726432532 0.977859113507933 1 GO:0005126 cytokine receptor binding 58/4869 275/18639 0.210909090909091 0.807380272223156 0.978216050067874 1 GO:0042379 chemokine receptor binding 12/4869 72/18639 0.166666666666667 0.638016019716574 0.979472900535832 1 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 16/4869 91/18639 0.175824175824176 0.673071844975727 0.979705083135554 1 GO:0004465 lipoprotein lipase activity 1/4869 13/18639 0.0769230769230769 0.29446893217688 0.980501358924349 1 GO:0004993 G protein-coupled serotonin receptor activity 1/4869 13/18639 0.0769230769230769 0.29446893217688 0.980501358924349 1 GO:0089720 caspase binding 1/4869 13/18639 0.0769230769230769 0.29446893217688 0.980501358924349 1 GO:0015145 monosaccharide transmembrane transporter activity 3/4869 26/18639 0.115384615384615 0.441703398265321 0.980679202143781 1 GO:0015081 sodium ion transmembrane transporter activity 32/4869 164/18639 0.195121951219512 0.746945584058428 0.981055739170296 1 GO:0020037 heme binding 27/4869 142/18639 0.190140845070423 0.727877430944261 0.981598383320792 1 GO:0015106 bicarbonate transmembrane transporter activity 4/4869 32/18639 0.125 0.478512014787431 0.981870356342342 1 GO:0008514 organic anion transmembrane transporter activity 56/4869 269/18639 0.20817843866171 0.796927072954531 0.982358494194677 1 GO:0015171 amino acid transmembrane transporter activity 18/4869 102/18639 0.176470588235294 0.675546373817549 0.983808256191449 1 GO:0005104 fibroblast growth factor receptor binding 3/4869 27/18639 0.111111111111111 0.425344013144383 0.984719484442292 1 GO:0001846 opsonin binding 2/4869 21/18639 0.0952380952380952 0.364580582695185 0.985440117810177 1 GO:0005248 voltage-gated sodium channel activity 2/4869 21/18639 0.0952380952380952 0.364580582695185 0.985440117810177 1 GO:0005344 oxygen carrier activity 1/4869 14/18639 0.0714285714285714 0.273435437021389 0.985598474966298 1 GO:0008392 arachidonate epoxygenase activity 1/4869 14/18639 0.0714285714285714 0.273435437021389 0.985598474966298 1 GO:0005253 monoatomic anion channel activity 18/4869 103/18639 0.174757281553398 0.668987671159126 0.98584041794452 1 GO:0008509 monoatomic anion transmembrane transporter activity 28/4869 149/18639 0.187919463087248 0.719373767197211 0.986163815424974 1 GO:0017171 serine hydrolase activity 39/4869 198/18639 0.196969696969697 0.754018932392315 0.986254196823618 1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 5/4869 39/18639 0.128205128205128 0.490781553628134 0.986689190009775 1 GO:0008236 serine-type peptidase activity 38/4869 194/18639 0.195876288659794 0.749833260285458 0.986810057169354 1 GO:0005242 inward rectifier potassium channel activity 3/4869 28/18639 0.107142857142857 0.410153155532083 0.98794217615266 1 GO:0051119 sugar transmembrane transporter activity 3/4869 28/18639 0.107142857142857 0.410153155532083 0.98794217615266 1 GO:0004129 cytochrome-c oxidase activity 1/4869 15/18639 0.0666666666666667 0.25520640788663 0.989363362235511 1 GO:0004953 icosanoid receptor activity 1/4869 15/18639 0.0666666666666667 0.25520640788663 0.989363362235511 1 GO:0015250 water channel activity 1/4869 15/18639 0.0666666666666667 0.25520640788663 0.989363362235511 1 GO:0031386 protein tag activity 1/4869 15/18639 0.0666666666666667 0.25520640788663 0.989363362235511 1 GO:0048531 beta-1,3-galactosyltransferase activity 1/4869 15/18639 0.0666666666666667 0.25520640788663 0.989363362235511 1 GO:0055105 ubiquitin-protein transferase inhibitor activity 1/4869 15/18639 0.0666666666666667 0.25520640788663 0.989363362235511 1 GO:0141047 molecular tag activity 1/4869 15/18639 0.0666666666666667 0.25520640788663 0.989363362235511 1 GO:0072341 modified amino acid binding 15/4869 91/18639 0.164835164835165 0.631004854664744 0.98964343305361 1 GO:0005416 amino acid:monoatomic cation symporter activity 3/4869 29/18639 0.103448275862069 0.396009943272356 0.990505352462063 1 GO:0015294 solute:monoatomic cation symporter activity 20/4869 116/18639 0.172413793103448 0.660016572120594 0.991324467473369 1 GO:0016917 GABA receptor activity 2/4869 23/18639 0.0869565217391304 0.332877923330387 0.991392225380548 1 GO:0031681 G-protein beta-subunit binding 2/4869 23/18639 0.0869565217391304 0.332877923330387 0.991392225380548 1 GO:0099095 ligand-gated monoatomic anion channel activity 6/4869 47/18639 0.127659574468085 0.488693121485036 0.99204057600334 1 GO:0005149 interleukin-1 receptor binding 1/4869 16/18639 0.0625 0.239256007393715 0.992144171367561 1 GO:0008391 arachidonate monooxygenase activity 1/4869 16/18639 0.0625 0.239256007393715 0.992144171367561 1 GO:0016675 oxidoreductase activity, acting on a heme group of donors 1/4869 16/18639 0.0625 0.239256007393715 0.992144171367561 1 GO:0022841 potassium ion leak channel activity 1/4869 16/18639 0.0625 0.239256007393715 0.992144171367561 1 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 1/4869 16/18639 0.0625 0.239256007393715 0.992144171367561 1 GO:0016859 cis-trans isomerase activity 5/4869 42/18639 0.119047619047619 0.455725728368982 0.99290047001464 1 GO:0015149 hexose transmembrane transporter activity 2/4869 24/18639 0.0833333333333333 0.319008009858287 0.993397004410283 1 GO:0055056 D-glucose transmembrane transporter activity 2/4869 24/18639 0.0833333333333333 0.319008009858287 0.993397004410283 1 GO:0030414 peptidase inhibitor activity 31/4869 169/18639 0.183431952662722 0.702195145960253 0.993432794121226 1 GO:0015103 inorganic anion transmembrane transporter activity 30/4869 165/18639 0.181818181818182 0.696017476054445 0.993856493374802 1 GO:0022829 wide pore channel activity 4/4869 37/18639 0.108108108108108 0.413848229005345 0.994022191915291 1 GO:0046943 carboxylic acid transmembrane transporter activity 35/4869 188/18639 0.186170212765957 0.712677468832344 0.994055848695653 1 GO:0004659 prenyltransferase activity 1/4869 17/18639 0.0588235294117647 0.22518212460585 0.994198084787061 1 GO:0016805 dipeptidase activity 1/4869 17/18639 0.0588235294117647 0.22518212460585 0.994198084787061 1 GO:0004866 endopeptidase inhibitor activity 29/4869 161/18639 0.180124223602484 0.689532841184372 0.994273461414474 1 GO:0005342 organic acid transmembrane transporter activity 35/4869 189/18639 0.185185185185185 0.708906688573971 0.994695785021788 1 GO:0005372 water transmembrane transporter activity 1/4869 18/18639 0.0555555555555556 0.212672006572191 0.99571508216499 1 GO:0022851 GABA-gated chloride ion channel activity 1/4869 18/18639 0.0555555555555556 0.212672006572191 0.99571508216499 1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/4869 18/18639 0.0555555555555556 0.212672006572191 0.99571508216499 1 GO:0004890 GABA-A receptor activity 1/4869 19/18639 0.0526315789473684 0.201478743068392 0.996835498089949 1 GO:0099589 serotonin receptor activity 1/4869 19/18639 0.0526315789473684 0.201478743068392 0.996835498089949 1 GO:0015144 carbohydrate transmembrane transporter activity 4/4869 40/18639 0.1 0.382809611829945 0.997000504063853 1 GO:0071855 neuropeptide receptor binding 4/4869 40/18639 0.1 0.382809611829945 0.997000504063853 1 GO:0019825 oxygen binding 3/4869 34/18639 0.0882352941176471 0.337773186908775 0.997204259323858 1 GO:0046873 metal ion transmembrane transporter activity 93/4869 450/18639 0.206666666666667 0.791139864448552 0.997292386118445 1 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7/4869 58/18639 0.120689655172414 0.462011600484416 0.997367916321818 1 GO:0008227 G protein-coupled amine receptor activity 4/4869 41/18639 0.0975609756097561 0.373472792029214 0.997624678559033 1 GO:0015464 acetylcholine receptor activity 1/4869 20/18639 0.05 0.191404805914972 0.997662993245698 1 GO:0022804 active transmembrane transporter activity 94/4869 457/18639 0.205689277899344 0.787398326302293 0.997836783635326 1 GO:0003823 antigen binding 30/4869 174/18639 0.172413793103448 0.660016572120594 0.99800086980405 1 GO:0004869 cysteine-type endopeptidase inhibitor activity 3/4869 36/18639 0.0833333333333333 0.319008009858287 0.998304596188642 1 GO:0004252 serine-type endopeptidase activity 30/4869 176/18639 0.170454545454545 0.652516383801042 0.998460159079759 1 GO:0005272 sodium channel activity 5/4869 51/18639 0.0980392156862745 0.37530354100975 0.999026617863488 1 GO:0015295 solute:proton symporter activity 1/4869 24/18639 0.0416666666666667 0.159504004929144 0.999304982424815 1 GO:0005251 delayed rectifier potassium channel activity 1/4869 25/18639 0.04 0.153123844731978 0.999486773484368 1 GO:0015079 potassium ion transmembrane transporter activity 25/4869 160/18639 0.15625 0.598140018484288 0.999494697626917 1 GO:0015108 chloride transmembrane transporter activity 17/4869 121/18639 0.140495867768595 0.537831686042071 0.99957169009881 1 GO:0015252 proton channel activity 1/4869 27/18639 0.037037037037037 0.141781337714794 0.999720159292797 1 GO:0003954 NADH dehydrogenase activity 3/4869 44/18639 0.0681818181818182 0.261006553520417 0.999781762346333 1 GO:0015399 primary active transmembrane transporter activity 25/4869 166/18639 0.150602409638554 0.576520499743892 0.999795977952089 1 GO:0005254 chloride channel activity 9/4869 83/18639 0.108433734939759 0.415094759815603 0.999840265463691 1 GO:0005125 cytokine activity 38/4869 234/18639 0.162393162393162 0.621656634595636 0.999895844269173 1 GO:0005184 neuropeptide hormone activity 1/4869 31/18639 0.032258064516129 0.123486971558047 0.999916820694352 1 GO:0099094 ligand-gated monoatomic cation channel activity 18/4869 136/18639 0.132352941176471 0.506659780363162 0.999920903424166 1 GO:0160041 neuropeptide activity 1/4869 32/18639 0.03125 0.119628003696858 0.999938585528788 1 GO:0009055 electron transfer activity 14/4869 116/18639 0.120689655172414 0.462011600484416 0.999939768118232 1 GO:0003730 mRNA 3'-UTR binding 43/4869 262/18639 0.16412213740458 0.628275317125481 0.999940355129134 1 GO:0042923 neuropeptide binding 1/4869 33/18639 0.0303030303030303 0.116002912675741 0.999954656204358 1 GO:0008528 G protein-coupled peptide receptor activity 14/4869 122/18639 0.114754098360656 0.439289718493379 0.999981105928105 1 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 1/4869 36/18639 0.0277777777777778 0.106336003286096 0.9999817522344 1 GO:0030280 structural constituent of skin epidermis 1/4869 37/18639 0.027027027027027 0.103462057251336 0.999986528258198 1 GO:0008188 neuropeptide receptor activity 2/4869 48/18639 0.0416666666666667 0.159504004929144 0.999991385225091 1 GO:0022843 voltage-gated monoatomic cation channel activity 17/4869 143/18639 0.118881118881119 0.455088349727906 0.999991815722029 1 GO:0005249 voltage-gated potassium channel activity 9/4869 98/18639 0.0918367346938776 0.351559847598929 0.999993709332923 1 GO:0001653 peptide receptor activity 14/4869 128/18639 0.109375 0.418698012939002 0.999994262977643 1 GO:0005267 potassium channel activity 13/4869 124/18639 0.104838709677419 0.401332657563652 0.999995993968754 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity 1/4869 41/18639 0.024390243902439 0.0933681980073035 0.999995998736077 1 GO:0022834 ligand-gated channel activity 24/4869 188/18639 0.127659574468085 0.488693121485036 0.999997783772223 1 GO:0005244 voltage-gated monoatomic ion channel activity 21/4869 173/18639 0.121387283236994 0.464682187770453 0.999998206209035 1 GO:0022832 voltage-gated channel activity 21/4869 175/18639 0.12 0.459371534195933 0.999998764115937 1 GO:0015276 ligand-gated monoatomic ion channel activity 23/4869 186/18639 0.123655913978495 0.473366724305845 0.999998792151746 1 GO:0022853 active monoatomic ion transmembrane transporter activity 11/4869 118/18639 0.0932203389830508 0.356856417807575 0.999998859612213 1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/4869 56/18639 0.0357142857142857 0.136717718510694 0.99999912166059 1 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 3/4869 68/18639 0.0441176470588235 0.168886593454387 0.999999657181873 1 GO:0022824 transmitter-gated monoatomic ion channel activity 2/4869 63/18639 0.0317460317460317 0.121526860898395 0.999999882814493 1 GO:0022835 transmitter-gated channel activity 2/4869 63/18639 0.0317460317460317 0.121526860898395 0.999999882814493 1 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 1/4869 53/18639 0.0188679245283019 0.0722282286471593 0.999999895354085 1 GO:0015078 proton transmembrane transporter activity 20/4869 185/18639 0.108108108108108 0.413848229005345 0.999999939388333 1 GO:0005179 hormone activity 11/4869 132/18639 0.0833333333333333 0.319008009858287 0.999999950338182 1 GO:0005261 monoatomic cation channel activity 49/4869 341/18639 0.143695014662757 0.550078327849481 0.999999958547079 1 GO:0098960 postsynaptic neurotransmitter receptor activity 2/4869 69/18639 0.0289855072463768 0.110959307776796 0.999999979357451 1 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/4869 73/18639 0.0273972602739726 0.104879345706834 0.999999993541417 1 GO:0005216 monoatomic ion channel activity 67/4869 448/18639 0.149553571428571 0.572505446263533 0.999999997013519 1 GO:0030594 neurotransmitter receptor activity 4/4869 97/18639 0.0412371134020619 0.157859633744307 0.999999998827761 1 GO:0022836 gated channel activity 39/4869 318/18639 0.122641509433962 0.469483486206536 0.99999999969618 1 GO:0003735 structural constituent of ribosome 6/4869 175/18639 0.0342857142857143 0.131249009770267 1 1 GO:0030371 translation repressor activity 11/4869 329/18639 0.033434650455927 0.127991055627033 1 1 GO:0045182 translation regulator activity 17/4869 356/18639 0.047752808988764 0.182802342727783 1 1