category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	56/2531	93/9376	2.23064537371008	INSR/SORBS1/TCF7L2/VCL/FGFR1/PTPRM/ROCK2/SMAD3/PTPN1/TCF7L1/IGF1R/TGFBR1/ARHGAP29/TJP1/EGFR/ACTN4/TGFBR2/AFDN/WASF2/WASL/ROCK1/RAP1B/IQGAP1/PARD3/CTNND1/CREBBP/SMURF2/FARP2/CTNNA3/RAP1A/SMURF1/FER/KRIT1/CTNNB1/RADIL/MYL9/NECTIN2/MAPK1/LMO7/CTNNA1/ERBB2/WASF1/PTPRB/SRC/FYN/NLK/CDH5/TCF7/CTNNA2/CDH1/PTPRF/RASIP1/LEF1/PTPN6/MET/WAS	7.2522907506076
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	56/2531	93/9376	2.23064537371008	FOS/HLA-DRA/MAPK10/NFATC2/JUN/NFATC1/HLA-DPA1/HLA-DPB1/JAG1/HLA-DRB1/JAK2/MAML3/STAT5B/IL4R/NFKBIA/NOTCH3/PPP3CB/HLA-DQB1/STAT5A/MAML2/HLA-DQA1/MAF/IFNGR1/NFKB1/HLA-DMA/NOTCH1/HLA-DRB5/NFKBIE/MAPK8/MAPK14/GATA3/RBPJ/MAPK1/IFNGR2/PPP3CA/DLL1/HLA-DQA2/HLA-DMB/NFATC3/IKBKB/CD4/STAT4/IL2RB/IL2RA/RUNX3/CD247/HLA-DOA/CD3E/CD3D/IL2RG/MAPK11/LCK/IFNG/PRKCQ/DLL4/JAK3	7.2522907506076
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	107/2531	224/9376	1.76954337641813	FOS/ZFP36/EGR1/AKT3/TLN2/HLA-DRA/MAPK10/NFATC2/MYC/JUN/NFATC1/IL15/MSX1/CREB5/SMAD3/HLA-DPA1/CCND2/ADCY3/HLA-DPB1/PIK3R1/ETS2/HLA-DRB1/TGFBR1/IL15RA/STAT5B/ETS1/NFKBIA/PTEN/CREB3L2/TGFBR2/CRTC3/PPP3CB/HLA-DQB1/STAT5A/ADCY9/CHEK2/KAT2B/ATF4/PIK3CA/CREBBP/HLA-DQA1/MAP3K14/NFKB1/HLA-DMA/NFYB/ADCY1/ATF2/IL1R1/ADCY2/TGFB2/FOSL1/AKT2/HLA-DRB5/CRTC1/SRF/MAP2K4/MAP3K3/HLA-G/MAPK8/ELK4/ANAPC7/RELB/DLG1/CD40/CDKN2C/MAPK1/ATR/TRRAP/PPP3CA/ANAPC4/MMP7/RANBP3/ITGB2/PIK3R3/ADCY4/HLA-DQA2/HLA-DMB/KAT2A/HLA-E/NFATC3/IKBKB/ADCY7/CCND3/CD4/PIK3CB/IL1R2/SLC2A1/EGR2/IL2RB/IL2RA/MAP3K1/SPI1/TGFB3/POLB/HLA-DOA/CREB3L4/CD3E/CD3D/IL2RG/CDK2/ADCY5/TNF/LCK/CDC23/JAK3/ITGAL/CCNA1	7.0883326828592
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	62/2531	109/9376	2.10712667510032	FOS/HLA-DRA/MAPK10/RORA/NFATC2/JUN/NFATC1/IL6R/SMAD3/STAT3/HLA-DPA1/HLA-DPB1/HLA-DRB1/JAK2/TGFBR1/STAT5B/IL4R/NFKBIA/TGFBR2/PPP3CB/HLA-DQB1/STAT5A/HLA-DQA1/IFNGR1/NFKB1/HLA-DMA/RARA/RXRA/IL1R1/HLA-DRB5/EBI3/IL1RAP/NFKBIE/MAPK8/MAPK14/GATA3/MAPK1/IFNGR2/PPP3CA/HLA-DQA2/HSP90AA1/HLA-DMB/NFATC3/IKBKB/MTOR/CD4/IL6ST/IL2RB/IL2RA/CD247/HLA-DOA/CD3E/CD3D/IRF4/IL2RG/MAPK11/LCK/IFNG/IL23A/PRKCQ/JAK3/HSP90AB1	7.06945552780127
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	98/2531	203/9376	1.78836223926757	COL6A3/COL4A1/LAMA2/EMP1/THBS1/COL4A2/VCL/AKT3/TLN2/TNXB/FLT1/MAPK10/ITGB8/PDGFRB/VWF/JUN/ITGA6/PPP1R12B/ROCK2/BCL2/LAMB1/COL4A4/PDGFD/CCND2/TNC/IGF1/LAMA3/IGF1R/PIK3R1/PAK3/ITGA1/MYLK/BRAF/EGFR/ACTN4/THBS3/PTEN/PPP1R12A/PARVA/ROCK1/RAPGEF1/RAP1B/CAV1/COL4A3/PIK3CA/LAMA4/DIAPH1/ZYX/PDGFRA/DOCK1/PPP1R12C/BIRC2/LAMC1/ITGA9/EMP2/SOS2/AKT2/RAP1A/PIP5K1C/HGF/MAPK8/RAF1/CTNNB1/LAMC3/RELN/MYL9/PAK2/MAPK1/PPP1CB/VAV3/PIK3R3/ERBB2/VAV2/FLT4/PRKCG/SRC/FYN/THBS4/SOS1/CCND3/ITGA7/PDGFB/PIK3CB/PGF/PDGFC/ITGA4/KDR/ITGB4/COMP/VTN/COL6A2/ITGA5/PIP5K1B/ITGA8/PARVG/MET/VAV1/RASGRF1	6.9049910682915
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	79/2531	157/9376	1.86402997732575	TCF7L2/CCN2/MYC/SMAD7/LATS2/TEAD1/STK3/SMAD3/SERPINE1/CCND2/BMP6/TCF7L1/TGFBR1/WNT9A/TGFBR2/WTIP/FRMD6/FBXW11/PARD3/DLG2/PPP2CB/TEAD3/WNT2/GDF7/TP53BP2/BIRC2/RASSF1/PPP2CA/DLG5/CTNNA3/TGFB2/PPP2R2A/WWTR1/PPP2R2D/TEAD4/PPP2R1B/CTNNB1/DLG1/PPP1CB/BTRC/WNT5B/AXIN1/APC/CTNNA1/BMPR2/WNT2B/ITGB2/SMAD1/NKD1/NKD2/BMPR1A/BBC3/CCND3/YAP1/FZD8/LATS1/AMOT/PRKCZ/FZD4/YWHAZ/LIMD1/TCF7/FGF1/CTNNA2/BMP4/CDH1/BMP8A/TGFB3/BMPR1B/LEF1/AXIN2/FZD3/PATJ/WNT11/WNT6/LLGL2/PPP2R2B/WNT5A/BMP7	6.63867967310551
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	130/2531	300/9376	1.60526801000922	FOS/INSR/NR4A1/DUSP1/MAP3K5/CACNB2/AKT3/FLT1/GADD45B/MAPK10/HSPA1B/PDGFRB/MYC/JUN/NFATC1/HSPA1A/FGFR1/JUND/HSPB1/RASGRP2/STK3/PDGFD/GADD45G/RPS6KA2/ANGPT1/CSF1/GADD45A/NTRK1/MAP3K20/IGF1/IGF1R/HSPA6/TGFBR1/MAP4K3/MAP2K3/MAP3K4/CACNA1C/BRAF/EGFR/RASA2/NGF/TGFBR2/PPM1B/PPP3CB/MAPKAPK2/RAP1B/RRAS2/ATF4/TEK/DUSP2/FLT3LG/RAPGEF2/MRAS/MAP3K14/PDGFRA/TAOK3/NFKB1/MEF2C/DUSP8/ANGPT2/ATF2/RASA1/DUSP16/SOS2/IL1R1/TGFB2/AKT2/DUSP5/RAP1A/FAS/SRF/MAP2K4/HGF/IL1RAP/MAP3K3/MAPK8/MAPK14/ELK4/RAF1/RELB/TRAF6/RPS6KA5/PAK2/RASGRF2/MAPK1/FGF7/PPM1A/GNA12/PPP3CA/MAP3K8/MAP2K5/IGF2/ERBB2/FLT4/MECOM/CSF1R/MAP3K6/PRKCG/NFATC3/IKBKB/MKNK2/RRAS/SOS1/NLK/RASGRP3/ARRB2/PDGFB/DUSP7/CACNA1D/KITLG/CACNA1H/PGF/MAP3K1/FGF1/EFNA1/PDGFC/NGFR/KDR/PTPN7/NTRK2/TGFB3/PLA2G4A/CACNB1/FGF10/HSPA1L/MAPK11/TNF/MET/RASGRP1/RASGRF1	6.47897179340194
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	98/2531	212/9376	1.71244120080809	THBS1/INSR/LPAR1/AKT3/TLN2/FLT1/PDGFRB/CNR1/FGFR1/RASGRP2/PDGFD/PLCE1/ANGPT1/GNAI1/CSF1/PRKD1/F2R/ADCY3/DOCK4/IGF1/IGF1R/PIK3R1/MAP2K3/GNAQ/MAGI3/APBB1IP/BRAF/EGFR/NGF/AFDN/SIPA1L2/RAPGEF1/ADCY9/RAP1B/PARD3/CTNND1/PIK3CA/TEK/RAPGEF2/MRAS/PDGFRA/MAGI1/ADCY1/RAPGEF5/ANGPT2/FARP2/EVL/ADCY2/AKT2/RAP1A/LCP2/TIAM1/HGF/KRIT1/MAPK14/GNAO1/RAF1/CTNNB1/MAPK1/FGF7/VAV3/ITGB2/PIK3R3/ADCY4/VAV2/FLT4/CSF1R/PRKCG/P2RY1/ADCY7/SRC/RRAS/RASGRP3/PDGFB/SKAP1/PIK3CB/PRKCZ/KITLG/FYB1/ENAH/PGF/RAPGEF4/FGF1/EFNA1/PDGFC/NGFR/KDR/CDH1/FGF10/RAPGEF3/MAPK11/ADCY5/LPAR2/MET/ITGAL/VAV1/RASSF5/ITGAM	6.37998124025556
NA	NA	hsa04518	Integrin signaling	76/2531	154/9376	1.82817735405645	COL6A3/COL4A1/LAMA2/THBS1/COL4A2/VCL/AKT3/TLN2/TNXB/FLT1/ITGB8/PDGFRB/FBN1/VWF/ITGA6/FERMT2/LAMB1/COL4A4/PDGFD/LIMS2/CCND2/TNC/IGF1/LAMA3/IGF1R/PIK3R1/ITGA1/EGFR/ACTN4/THBS3/PARVA/ARHGEF6/COL4A3/PIK3CA/LAMA4/PDGFRA/LAMC1/ITGA9/AKT2/HGF/VCAM1/NPNT/CTNNB1/LAMC3/RELN/ICAM2/ITGB2/PIK3R3/ERBB2/FLT4/FERMT3/SRC/THBS4/CCND3/ITGA7/PDGFB/MTOR/PIK3CB/NCK2/PGF/PDGFC/ITGA4/KDR/ITGB4/CDH1/COMP/VTN/COL6A2/ITGA5/ITGA8/PARVG/FREM1/ITGAD/MET/ITGAL/ITGAM	6.30109658801955
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	94/2531	204/9376	1.70695919616365	TIMP3/THBS1/LUM/SDC2/AKT3/PLCG2/ESR1/MYC/FGFR1/PPP1R12B/ROCK2/HOXD10/CAMK2D/SDC4/TLR4/PDCD4/STAT3/PLCE1/DCN/IGF1/IGF1R/PIK3R1/CD44/WNT9A/PLAU/BRAF/EGFR/DDX5/PPP1R12A/ROCK1/TWIST2/HSPB2/PTPN11/IQGAP1/CAV1/ANK2/RRAS2/PIK3CA/ARHGEF12/ITPR1/MRAS/WNT2/PPP1R12C/SOS2/TGFB2/AKT2/FAS/RPS6KB1/TIAM1/HGF/HSPG2/MAPK14/GAB1/RAF1/CTNNB1/CBL/MAPK1/PPP1CB/WNT5B/VAV3/HCLS1/WNT2B/PIK3R3/IGF2/ERBB2/VAV2/ANK3/DROSHA/GPC3/PRKCG/CAMK2G/SRC/RRAS/SOS1/MTOR/FZD8/PIK3CB/PTCH1/FZD4/HBEGF/HPSE2/KDR/VTN/ITGA5/MAPK11/TNF/PTPN6/FZD3/HPSE/MET/WNT11/WNT6/VAV1/WNT5A	6.20758097462372
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	63/2531	122/9376	1.91296124774112	FOS/AKT3/CBLB/MAPK10/NFATC2/JUN/NFATC1/PIK3R1/PAK3/NFKBIA/PPP3CB/PTPN11/PIK3CA/PPP2CB/MAP3K14/NFKB1/MALT1/PPP2CA/SOS2/PPP2R3A/AKT2/PPP2R2A/LCP2/NFKBIE/MAPK8/PPP2R2D/MAPK14/PPP2R1B/RAF1/DLG1/PAK2/MAPK1/VAV3/PTPRC/PPP3CA/MAP3K8/PPP2R5D/PIK3R3/PPP2R5A/VAV2/NFATC3/IKBKB/FYN/SOS1/CD4/PIK3CB/NCK2/IL10/CD247/PPP2R3B/CD3E/CD3D/MAPK11/TNF/PTPN6/LCK/ITK/IFNG/GRAP2/PRKCQ/RASGRP1/VAV1/PPP2R2B	6.17180926162913
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	147/2531	362/9376	1.50429917640048	COL6A3/COL4A1/LAMA2/THBS1/INSR/COL4A2/MCL1/NR4A1/LPAR1/PRLR/AKT3/TNXB/FLT1/ITGB8/PDGFRB/MYC/VWF/FGFR1/ITGA6/IL6R/BCL2/CREB5/LAMB1/TLR4/COL4A4/PDGFD/SGK1/ANGPT1/CSF1/NTRK1/CCND2/TNC/F2R/CSH1/IGF1/LAMA3/IGF1R/PIK3R1/JAK2/ITGA1/EGFR/IL4R/THBS3/PTEN/CREB3L2/GHR/NGF/GNG4/COL4A3/ATF4/PIK3CA/TEK/LAMA4/PPP2CB/FLT3LG/PDGFRA/MAGI1/NFKB1/PKN2/CSF3/RXRA/LAMC1/ITGA9/PPP2CA/ANGPT2/PRKAA1/ATF2/SOS2/PPP2R3A/AKT2/PHLPP2/PPP2R2A/CSH2/RPS6KB1/OSMR/HGF/IRS1/GNB4/FOXO3/GNB5/PPP2R2D/PPP2R1B/RAF1/RBL2/LAMC3/LPAR6/RELN/MAPK1/FGF7/RPTOR/CSF3R/PPP2R5D/PIK3R3/PPP2R5A/PHLPP1/IGF2/ERBB2/FLT4/CSF1R/HSP90AA1/GNG7/IKBKB/CDKN1B/PIK3R5/THBS4/SOS1/CCND3/ITGA7/PDGFB/MTOR/PIK3CB/IL3RA/KITLG/IL7/YWHAZ/PGF/IL2RB/IL2RA/FGF1/EFNA1/PDGFC/NGFR/ITGA4/KDR/ITGB4/NTRK2/COMP/CASP9/VTN/COL6A2/FGF10/ITGA5/PPP2R3B/CREB3L4/ITGA8/IL2RG/CDK2/PKN3/IL7R/LPAR2/PIK3AP1/MET/OSM/JAK3/HSP90AB1/PPP2R2B/SYK	5.95016147630141
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	103/2531	233/9376	1.63759595606751	COL6A3/COL4A1/FBLN1/LAMA2/THBS1/COL4A2/NID1/SDC2/LMOD1/VCL/FHL1/TLN2/PDLIM1/SYNPO2/ITGB8/DES/ACTG2/COL5A3/DAAM1/FBN1/DMD/MYH11/ELN/ITGA6/SYNE1/SYNE2/SGCD/SDC4/FMNL2/COL4A4/SGCE/DIAPH2/DCN/CSRP1/SUN1/ITGA1/SDC3/SPTBN1/THBS3/DTNA/FBLN2/SSPN/MYH10/TMEM43/TMOD3/COL27A1/SYNE3/ANK2/COL4A3/TMOD1/PDLIM5/FHL2/COL5A1/VIM/DIAPH1/TPM1/ZYX/DAAM2/SNTB2/CSRP2/ITGA9/SUN2/TMOD2/LMNA/CAPN3/HSPG2/AMPD3/MYL9/MYL3/COL11A1/FBN2/DAG1/ANK3/TNNT3/DSP/TTN/THBS4/ITGA7/MYOM1/SNTB1/PKP2/PDLIM3/JUP/COL24A1/BGN/ITGA4/LDB3/ITGB4/MYH13/COMP/ATP1B2/COL6A2/ITGA5/ITGA8/VCAN/ENO3/MYH3/XIRP1/TNNI2/SGCZ/MYPN/MYOM2/TNNC2	5.99272210564133
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	55/2531	103/9376	1.97811218559762	FOS/AKT3/MAPK10/JUN/CFLAR/C1QA/C1QB/TLR4/GNAI1/SERPINE1/PIK3R1/GNA14/TGFBR1/GNAQ/NFKBIA/CCL3/TGFBR2/ACE/PIK3CA/C1QC/PPP2CB/CCL3L1/IFNGR1/NFKB1/ADCY1/PPP2CA/TGFB2/AKT2/FAS/PPP2R2A/MAP2K4/MAPK8/PPP2R2D/MAPK14/GNAL/GNAO1/PPP2R1B/TRAF6/MAPK1/CCL5/IFNGR2/PIK3R3/IKBKB/PIK3CB/IL10/CD247/TGFB3/CD3E/CD3D/MAPK11/TNF/IFNG/KNG1/GNA15/PPP2R2B	6.06934935605211
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	75/2531	160/9376	1.73646779928882	NEGR1/SDC2/NRXN3/HLA-DRA/NLGN1/ITGB8/NLGN4X/ITGA6/PTPRM/SDC4/HLA-DPA1/HLA-DPB1/HLA-DRB1/NRXN2/SDC3/CLDN5/JAM3/VSIR/HLA-DQB1/JAM2/PTPRD/HLA-DQA1/HLA-DMA/LRRC4C/CD34/ITGA9/HLA-DRB5/PECAM1/VCAM1/HLA-G/CNTN1/NFASC/CD40/NECTIN2/PTPRC/ESAM/ICAM2/CLDN4/ITGB2/ALCAM/CNTNAP2/HLA-DQA2/HLA-DMB/HLA-E/NCAM2/CADM1/CD4/CDH5/PVR/CDH3/ITGA4/CDH1/SELE/PTPRF/HLA-DOA/ITGA8/NRXN1/CLDN10/VCAN/CD2/CD22/NCAM1/SELP/SIGLEC1/CD80/CLDN7/JAML/SPN/NRCAM/CD6/CD86/CDH4/CD274/ITGAL/ITGAM	5.7133062703576
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	81/2531	178/9376	1.68573952650061	TCF7L2/DKK1/ROR1/MAPK10/CCN4/APCDD1/NFATC2/TLE2/DAAM1/MYC/SERPINF1/JUN/NFATC1/ROCK2/CAMK2D/PRICKLE1/MCC/TBL1X/SMAD3/NOTUM/CCND2/PRICKLE2/TCF7L1/ROR2/RSPO1/WNT9A/CTBP2/PPP3CB/TBL1XR1/SFRP2/FBXW11/SIRT1/CREBBP/TLE1/PSEN1/LRP6/RSPO3/WNT2/DAAM2/ZNRF3/SIAH1/FOSL1/SENP2/MAPK8/ANKRD6/LGR4/CTNNB1/TLE6/BTRC/WNT5B/AXIN1/APC/INVS/LRP5/PPP3CA/MMP7/WNT2B/NKD1/NKD2/PRKCG/NFATC3/CAMK2G/TLE4/CCND3/GPC4/NLK/CXXC4/FZD8/FZD4/TCF7/CSNK1A1/SFRP4/CTNND2/CCDC88C/DKK2/LEF1/AXIN2/FZD3/WNT11/WNT6/WNT5A	5.61652202508247
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	73/2531	157/9376	1.72245808031366	THBS1/PBX1/NFATC2/GULP1/MFGE8/NFATC1/CAMK2D/C1QA/C1QB/SGK1/ELMO1/JAK2/PPARG/AXL/MAPKAPK2/PTPN11/ATP11B/ADAM17/PLA2G6/SIRT1/C1QC/DUSP2/STAB1/DOCK1/DUSP8/RXRA/DUSP16/PECAM1/DUSP5/PROS1/ATP8A2/ARNT/MERTK/MAPK14/RAB5A/ATP11C/NR1H3/LIPA/PTGER2/ANO6/RAB14/MAPK1/ABCA1/CASP7/CD36/NFATC3/CAMK2G/CD24/ATP11A/DUSP7/RAB7A/ANO3/SLC2A1/PTGER4/IL10/ANO4/TGFBRAP1/ALOX5/CX3CL1/HAVCR2/S1PR1/MAPK11/ARG1/PTPN6/GPR132/STAB2/MEGF10/AGER/ATP8A1/XKR4/CEBPB/SCARF1/ATP2A3	5.55092751213765
NA	NA	hsa04517	IgSF CAM signaling	121/2531	299/9376	1.49913117477064	FOXO1/SORBS1/VCL/AKT3/MAPK10/NLGN1/NLGN4X/PLCG2/MYH11/FGFR1/PMP22/EPB41L2/LRFN5/MBP/UNC5C/PIK3R1/PLXNA4/PAK3/PPFIA2/KCNQ3/TJP1/MYLK/SPTBN1/ACTN4/JAM3/SLIT2/MPDZ/AFDN/TJP2/MYH10/WASL/TUBA1A/RAP1B/PTPN11/IQGAP1/PARD3/JAM2/ANK2/EPB41L3/TRPC6/PTPRD/PIK3CA/SRGAP1/RAPGEF2/MAGI1/LRRC4C/RASA1/AKT2/RAP1A/LCP2/IL1RAP/CD2AP/MAPK8/MAPK14/MTSS2/CNTN1/NFASC/CTNNB1/TRAF6/MYL9/NECTIN2/PAK2/MAPK1/LMO7/VAV3/ESAM/ICAM2/ITGB2/PIK3R3/SRGAP2/VAV2/ANK3/CNTNAP2/PRKCG/PLXNA2/SRC/FYN/NTN1/NCAM2/ROBO4/INPP5D/CADM1/PIK3CB/SCN8A/CD96/NCK2/PVR/LRRTM4/ITGA4/KDR/CDH1/IL1RAPL1/PTPRF/ITGA5/MAPK11/CRTAM/CADM2/CD2/DOK2/TRIO/NCAM1/PTPN6/LCK/CD48/GLDN/CD80/DCC/CABLES1/TUBA3E/JAML/IL1RAPL2/UNC5D/NRCAM/PRKCQ/CD86/ITGAL/IGSF5/VAV1/MAP2/ITGAM/NTRK3	5.33364500754145
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	51/2531	100/9376	1.88927696562623	HLA-DRA/ITGA6/IL6R/CSF1/HLA-DPA1/HLA-DPB1/CD55/HLA-DRB1/CD44/ITGA1/IL4R/HLA-DQB1/ANPEP/HLA-DQA1/FLT3LG/HLA-DMA/CSF3/CD34/IL1R1/HLA-DRB5/GP1BB/MME/TFRC/CSF3R/CSF2RA/IL11RA/HLA-DQA2/CSF1R/HLA-DMB/CD36/CD24/CD4/IL1R2/IL3RA/KITLG/IL7/IL2RA/CD37/ITGA4/HLA-DOA/ITGA5/CD3E/CD3D/CD2/CD22/TNF/THPO/IL7R/CR1L/ITGAM/CD59	5.43627800276268
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	53/2531	106/9376	1.85223231924141	FOXO1/ZEB1/TCF7L2/AKT3/PDGFRB/AR/FGFR1/BCL2/CREB5/PDGFD/TCF7L1/IGF1/PLAT/IGF1R/PIK3R1/PLAU/BRAF/EGFR/NFKBIA/PTEN/CREB3L2/ERG/ATF4/PIK3CA/CREBBP/PDGFRA/NFKB1/SOS2/AKT2/RAF1/CTNNB1/MAPK1/INSRR/PIK3R3/ERBB2/HSP90AA1/FOLR2/IKBKB/CDKN1B/SOS1/PDGFB/MTOR/PIK3CB/IL1R2/TCF7/PDGFC/GRM5/CASP9/CREB3L4/CDK2/SLC19A1/LEF1/HSP90AB1	5.36557228485523
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	55/2531	112/9376	1.8191567421121	LAMA2/AKT3/HLA-DRA/MAPK10/HSPA1B/HSPA1A/ITGA6/BCL2/LAMB1/TLR4/STAT3/GNAI1/HLA-DPA1/HLA-DPB1/LAMA3/HSPA6/HLA-DRB1/JAK2/MAP2K3/NFKBIA/HLA-DQB1/HLA-DQA1/LAMA4/IFNGR1/NFKB1/HLA-DMA/BIRC2/LAMC1/TGFB2/AKT2/HLA-DRB5/MAPK8/MAPK14/GNAO1/LAMC3/TRAF6/CD40/MAPK1/IFNGR2/HLA-DQA2/HLA-DMB/IKBKB/CIITA/PIK3R5/SOCS1/IL10/ALOX5/TGFB3/CASP9/HLA-DOA/IL10RA/HSPA1L/MAPK11/TNF/IFNG	5.30300129014945
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	34/2531	59/9376	2.13477623234603	TCF7L2/AKT3/GADD45B/MYC/GADD45G/GADD45A/TCF7L1/PIK3R1/BRAF/EGFR/PTEN/PIK3CA/POLK/SOS2/CTNNA3/AKT2/FOXO3/RAF1/CTNNB1/MLH1/MAPK1/AXIN1/APC/CTNNA1/PIK3R3/ERBB2/SOS1/PIK3CB/TCF7/CTNNA2/CDH1/CASP9/LEF1/AXIN2	5.31671246395957
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	86/2531	201/9376	1.58499482044538	FOXO1/ZBTB16/ZEB1/MITF/PBX1/NFKBIZ/FLT1/GADD45B/RUNX1T1/BCL6/MYC/GADD45G/HOXA10/GADD45A/NTRK1/IGFBP3/CCND2/PER2/REL/IGF1/AFF1/PLAT/IGF1R/PPARG/HPGD/WT1/PBX3/PLAU/JMJD1C/TGFBR2/DDX5/KDM6A/ERG/KLF3/HOXA11/DOT1L/NR4A3/MLF1/MLLT1/MAF/FUS/NFKB1/POLK/MEF2C/SUPT3H/NCOR1/TFE3/RARA/SIN3A/BIRC2/RXRA/SS18/EWSR1/ELK4/CD40/CCNT1/CDKN2C/TRAF1/BMI1/SMAD1/CSF1R/SP1/ETV6/NSD2/CDKN1B/IL1R2/JUP/HOXA9/GZMB/LYL1/IL2RB/NGFR/LMO2/TSPAN7/ELANE/SPI1/ARNT2/MYCN/CD86/MET/BCL11B/CEBPB/HHEX/CCNA1/ITGAM/BCL2A1	5.09790804675459
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	80/2531	184/9376	1.61063679934035	ABLIM1/BOC/NFATC2/PLCG2/TRPC4/ROCK2/EPHA3/CAMK2D/GNAI1/UNC5C/PIK3R1/PLXNA4/PAK3/ABLIM3/SEMA5A/SLIT2/PPP3CB/ROCK1/PTPN11/PLXNC1/PARD3/SEMA4A/NTN4/TRPC6/CXCL12/PIK3CA/ARHGEF12/SRGAP1/DPYSL2/GDF7/LRRC4C/SEMA4C/CXCR4/RASA1/SEMA3C/RGMA/CFL2/TRPC1/RAF1/EPHA6/SEMA3B/MYL9/PAK2/MAPK1/WNT5B/BMPR2/PPP3CA/PIK3R3/SRGAP2/NFATC3/CAMK2G/PLXNA2/SRC/FYN/NTN1/RRAS/PIK3CB/PTCH1/PRKCZ/FES/ENAH/NCK2/RND1/SEMA3D/SEMA6B/ABLIM2/EFNA1/SEMA6A/LRIG2/BMPR1B/EPHA7/SEMA4D/DCC/FZD3/SEMA7A/UNC5D/MET/WNT5A/EPHB3/BMP7	5.086650062253
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	35/2531	62/9376	2.0912300378532	FOXO1/IRS2/INSR/AKT3/HSPA1B/HSPA1A/CRYAB/PRKAG2/ADCY3/IGF1/IGF1R/HSPA6/PIK3R1/ADCY9/EIF4EBP2/PRKAB2/SIRT1/PIK3CA/ADCY1/PRKAA1/ADCY2/AKT2/RPS6KB1/ATG5/IRS1/FOXO3/RPTOR/PIK3R3/ADCY4/ADCY7/MTOR/PIK3CB/CLPB/HSPA1L/ADCY5	5.24190353638267
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	35/2531	62/9376	2.0912300378532	TLE2/HES1/JAG1/MAML3/CTBP2/NOTCH3/MAML2/HEYL/ADAM17/KAT2B/RFNG/CREBBP/TLE1/NCOR2/PSEN1/ITCH/NUMBL/SNW1/SPEN/CIR1/NOTCH1/TLE6/RBPJ/DLL1/KAT2A/TLE4/ATXN1L/NOTCH4/NRARP/DTX1/DTX4/MFNG/LFNG/DLL4/HEY1	5.24190353638267
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	46/2531	90/9376	1.89339303744677	FOS/AKT3/NFATC2/JUN/NFATC1/TLR4/STAT3/PIK3R1/JAK2/MAP2K3/EML4/EGFR/NFKBIA/PTEN/PPP3CB/BATF3/PTPN11/PIK3CA/IFNGR1/NFKB1/AKT2/RPS6KB1/MAP3K3/NFKBIE/MAPK14/RAF1/TRAF6/MAPK1/IFNGR2/PPP3CA/PIK3R3/NFATC3/IKBKB/MTOR/CD4/PIK3CB/CD247/CD3E/CD3D/MAPK11/PTPN6/LCK/IFNG/PRKCQ/CD274/RASGRP1	5.17838651567557
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	30/2531	50/9376	2.22267878308969	THBS1/SDC2/HBB/TLR4/HBA2/HBA1/THBS3/ACKR1/CSF3/TGFB2/PECAM1/HGF/VCAM1/CD40/ITGB2/CD36/THBS4/IL10/SELE/TGFB3/COMP/TNF/SELP/IL18/IFNG/CR1L/MET/ITGAL/KLRK1/KLRB1	5.27101991650012
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	65/2531	142/9376	1.69570564437594	FOS/FOSB/MITF/AKT3/JUNB/SOCS3/MAPK10/NFATC2/PLCG2/JUN/NFATC1/CTSK/FOSL2/JUND/CSF1/GAB2/PIK3R1/TGFBR1/PPARG/NFKBIA/TGFBR2/PPP3CB/TYROBP/FHL2/PIK3CA/ITPR1/MAP3K14/IFNGR1/NFKB1/IL1R1/TGFB2/FOSL1/AKT2/LCP2/FCGR2A/MAPK8/MAPK14/RELB/TRAF6/MAPK1/IFNGR2/PPP3CA/PIK3R3/TMEM64/CSF1R/IKBKB/NCF1/ACP5/FYN/PIK3CB/SOCS1/FCGR2B/SPI1/TREM2/MAPK11/TNF/LCK/IFNG/FCGR3A/LILRB2/NCF2/ATP2A3/LILRB4/LILRB5/SYK	5.07948577587302
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	53/2531	109/9376	1.80125344806962	FOXO1/IRS2/INSR/AKT3/SOCS3/MAPK10/CREB5/STAT3/RPS6KA2/PRKAG2/PTPN1/PIK3R1/OGT/ACACB/PRKCE/NFKBIA/PTEN/CREB3L2/PTPN11/PPP1R3B/PRKAB2/PIK3CA/NFKB1/OGA/PRKAA1/AKT2/RPS6KB1/IRS1/MAPK8/PYGL/SLC27A3/NR1H3/TBC1D4/SLC27A5/PPP1CB/PIK3R3/PYGM/PPARA/CD36/IKBKB/MTOR/SLC27A1/PIK3CB/PRKCZ/SLC2A1/PTPRF/CREB3L4/PPARGC1A/PRKCD/TNF/AGT/PRKCQ/SLC27A6	5.11633017704355
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	50/2531	101/9376	1.83389338538753	FOXO1/COL4A1/EGR1/COL4A2/AKT3/MAPK10/PIM1/PLCG2/JUN/NFATC1/BCL2/COL4A4/SMAD3/STAT3/PLCE1/SERPINE1/NOX4/PIK3R1/JAK2/TGFBR1/STAT5B/PRKCE/TGFBR2/STAT5A/COL4A3/PIK3CA/DIAPH1/NFKB1/TGFB2/AKT2/VCAM1/MAPK8/MAPK14/MAPK1/PLCD3/PIK3R3/CDKN1B/F3/EDN1/PIK3CB/PRKCZ/PLCD1/SELE/TGFB3/MAPK11/PRKCD/TNF/AGT/CYBB/AGER	5.12341152915984
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	96/2531	232/9376	1.5328819193722	RGCC/LPAR1/VCL/GSN/AKT3/ITGB8/PDGFRB/MYH11/FGFR1/ITGA6/PPP1R12B/ROCK2/PDGFD/DIAPH2/F2R/PIK3R1/PAK3/C7/ITGA1/MYLK/BRAF/EGFR/ACTN4/PPP1R12A/WASF2/MYH10/ARHGEF6/WASL/ROCK1/ARHGEF7/PIP4K2A/IQGAP1/CXCL12/RRAS2/PIK3CA/ARHGEF12/GNA13/DIAPH1/IQGAP2/MRAS/PDGFRA/DOCK1/PPP1R12C/ITGA9/CXCR4/SOS2/AKT2/PIP5K1C/TIAM1/ABI2/CFL2/RAF1/MYL9/PAK2/MAPK1/FGF7/PPP1CB/INSRR/VAV3/APC/GNA12/NCKAP1/ITGB2/PIK3R3/VAV2/CYFIP2/WASF1/SRC/RRAS/SOS1/PIKFYVE/ITGA7/PDGFB/PIK3CB/CHRM5/ENAH/FGF1/PDGFC/ITGA4/ITGB4/FGF10/ITGA5/PIP5K1B/ITGA8/C5/NCKAP1L/LPAR2/KNG1/C6/ITGAD/CHRM3/ITGAL/VAV1/SCIN/FGD3/ITGAM	4.99748907315201
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	98/2531	238/9376	1.52536779231645	INSR/AKT3/RASAL2/FLT1/MAPK10/PLCG2/PDGFRB/FGFR1/RASGRP2/PDGFD/PLCE1/ANGPT1/CSF1/RALGAPA1/NTRK1/GAB2/REL/IGF1/PLA2G2A/IGF1R/PIK3R1/ETS2/ABL2/PAK3/SHOC2/ETS1/EGFR/RASA2/NGF/AFDN/KSR1/RAP1B/PTPN11/GNG4/RRAS2/RASA3/PLA2G6/PIK3CA/TEK/FLT3LG/MRAS/PDGFRA/NFKB1/PLA2G5/RASSF1/RALGAPA2/RAPGEF5/ANGPT2/RASA1/SOS2/AKT2/RAP1A/TIAM1/HGF/GNB4/MAPK8/GNB5/RAB5A/GAB1/RAF1/PAK2/RASGRF2/MAPK1/FGF7/EXOC2/PIK3R3/IGF2/PLA1A/RALGAPB/FLT4/CSF1R/GNG7/PRKCG/IKBKB/RRAS/SOS1/RASGRP3/PDGFB/PLD2/PIK3CB/KITLG/PGF/FGF1/EFNA1/PDGFC/NGFR/KDR/RASA4/NTRK2/PLA2G4A/FOXO4/FGF10/KSR2/RASAL3/MET/RASGRP1/RASSF5/RASGRF1	4.99196269325089
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	53/2531	110/9376	1.78487841672354	THBS1/FBN1/MYC/LTBP1/SMAD7/THSD4/SMAD3/FMOD/ID4/LRRC32/BMP6/DCN/TGFBR1/SKI/CHRD/TGFBR2/ROCK1/CREBBP/LEFTY2/PPP2CB/GDF7/NCOR1/SIN3A/SMURF2/PPP2CA/TGFB2/RPS6KB1/SMURF1/FST/ACVR2A/RGMA/PPP2R1B/INHBB/MAPK1/TF/TFRC/BMPR2/SMAD1/LEMD3/TGIF2/SP1/BMPR1A/BMP4/E2F5/BMP8A/TGFB3/RBL1/BMPR1B/NOG/TNF/IFNG/ACVR2B/BMP7	5.0349778672857
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	51/2531	105/9376	1.79931139583451	AKT3/CBLB/MAPK10/NFATC2/PLCG2/JUN/NFATC1/IRF1/EGR3/PIK3R1/PLK3/NFKBIA/PPP3CB/KSR1/MAPKAPK2/PTPN11/RRAS2/PIK3CA/FCER1G/ARHGEF12/ITPR1/MRAS/MAP3K14/NFKB1/MALT1/LSP1/BCL3/AKT2/MAPK8/MAPK14/RAF1/RELB/MAPK1/PPP3CA/PIK3R3/NFATC3/IKBKB/SRC/RRAS/CARD9/PIK3CB/EGR2/NLRP3/IL17D/IL10/MAPK11/PRKCD/TNF/IL23A/CLEC7A/SYK	5.00832321234906
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	82/2531	193/9376	1.57391761842275	AKT3/PLCG2/CCL21/ROCK2/RASGRP2/STAT3/CCL14/GNAI1/ADCY3/CCL4/ELMO1/PIK3R1/JAK2/GNAQ/STAT5B/BRAF/NFKBIA/CCL4L2/CCL3/GRK5/ROCK1/ADCY9/RAP1B/PARD3/GNG4/CXCL12/PIK3CA/CCL3L1/CXCL2/NFKB1/ADCY1/CXCR4/CXCL16/SOS2/ADCY2/AKT2/RAP1A/CXCL13/CCL13/TIAM1/GNB4/FOXO3/GNB5/RAF1/MAPK1/CCL5/VAV3/GRK4/PIK3R3/ADCY4/VAV2/GNG7/IKBKB/ADCY7/NCF1/PIK3R5/SRC/SOS1/CCL8/GRK2/CCL26/ARRB2/PIK3CB/PTK2B/PRKCZ/CXCL9/XCL2/XCL1/CX3CL1/CCL18/FGR/ADCY5/PRKCD/GRK3/ITK/HCK/CCR10/JAK3/VAV1/PREX1/WAS/CCL23	4.89870067997697
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	56/2531	119/9376	1.74327747693309	FOS/MAP3K5/AKT3/JUNB/SOCS3/MAPK10/JUN/CFLAR/IL15/CREB5/CSF1/IRF1/TNFRSF1B/JAG1/PIK3R1/DAB2IP/MAP2K3/NFKBIA/CREB3L2/ADAM17/ATF4/PIK3CA/RIPK1/ITCH/MAP3K14/CXCL2/NFKB1/TNFAIP3/BIRC2/ATF2/BCL3/DNM1L/AKT2/FAS/MAP2K4/VCAM1/MAPK8/MAPK14/TRAF5/RPS6KA5/MAPK1/TRAF1/CCL5/MAP3K8/CASP7/PIK3R3/IKBKB/EDN1/PIK3CB/IL18R1/SELE/CX3CL1/CREB3L4/MAPK11/TNF/CEBPB	4.96174346341326
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	73/2531	168/9376	1.60967808695979	MCL1/PRLR/AKT3/FHL1/SOCS3/PIM1/SOCS2/PDGFRB/MYC/IL6R/IL15/BCL2/STAT3/AOX1/CCND2/CSH1/PIK3R1/JAK2/IL15RA/STAT5B/CLCF1/LIFR/EGFR/IL4R/GHR/STAT5A/PTPN11/PIK3CA/CREBBP/PDGFRA/IFNGR1/CSF3/SOS2/AKT2/CISH/CSH2/OSMR/PIAS1/STAM2/RAF1/STAM/CTF1/IFNGR2/CSF3R/CSF2RA/PIK3R3/IL11RA/CSF2RB/SOS1/CCND3/PDGFB/MTOR/PIK3CB/IL3RA/STAT4/SOCS1/IL7/IL6ST/IL19/IL2RB/IL2RA/IL10/LEPR/IL10RA/IL2RG/THPO/IL7R/PTPN6/IFNG/IL23A/OSM/JAK3/IL20RA	4.84861338428453
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	65/2531	148/9376	1.62696082095529	FOS/TCF7L2/AKT3/GADD45B/PGR/ESR1/MYC/JUN/FGFR1/HES1/GADD45G/GADD45A/TCF7L1/IGF1/IGF1R/JAG1/PIK3R1/WNT9A/NCOA1/BRAF/EGFR/NOTCH3/PTEN/HEYL/PIK3CA/LRP6/WNT2/POLK/NOTCH1/SOS2/AKT2/RPS6KB1/RAF1/CTNNB1/MAPK1/FGF7/WNT5B/AXIN1/APC/LRP5/WNT2B/PIK3R3/DLL1/ERBB2/FLT4/SP1/SOS1/MTOR/FZD8/PIK3CB/FZD4/TCF7/CSNK1A1/FGF1/NOTCH4/FGF10/LEF1/ESR2/AXIN2/FZD3/DLL4/WNT11/WNT6/HEY1/WNT5A	4.67479371788033
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	43/2531	87/9376	1.83094229258346	FOS/TCF7L2/AKT3/GADD45B/MAPK10/MYC/JUN/BCL2/GADD45G/SMAD3/GADD45A/TCF7L1/PIK3R1/TGFBR1/BRAF/EGFR/TGFBR2/PIK3CA/POLK/SOS2/TGFB2/AKT2/RPS6KB1/MAPK8/RAF1/CTNNB1/MLH1/MAPK1/AXIN1/APC/PIK3R3/SOS1/BBC3/PMAIP1/MTOR/PIK3CB/TCF7/TGFB3/CASP9/MSH2/LEF1/AXIN2/DCC	4.73468393957748
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	65/2531	149/9376	1.61604162081465	INSR/LPAR1/PLPP3/AKT3/PLCG2/PDGFRB/PDGFD/GAB2/F2R/ADCY3/PIK3R1/CYTH3/EGFR/ADCY9/PTPN11/CYTH1/AGPAT4/AVPR1A/RRAS2/PIK3CA/FCER1G/GNA13/MRAS/PDGFRA/ADCY1/GRM7/SOS2/ADCY2/AKT2/PIP5K1C/DGKH/GAB1/RAF1/LPAR6/MAPK1/GNA12/PIK3R3/DGKA/ADCY4/DNM3/ADCY7/PLPP1/PIK3R5/FYN/RRAS/SOS1/PDGFB/PLD2/MTOR/PIK3CB/PTK2B/KITLG/RAPGEF4/PDGFC/GRM5/DGKB/PLA2G4A/PIP5K1B/RAPGEF3/ADCY5/LPAR2/AGT/GRM8/CYTH4/SYK	4.60911891743099
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	43/2531	90/9376	1.76991088283068	FOXO1/IRS2/INSR/AKT3/CREB5/SESN3/PRKAG2/ADCY3/IGF1/IGF1R/PIK3R1/PPARG/SESN1/CREB3L2/ADCY9/CAMKK2/PRKAB2/ATF4/SIRT1/PIK3CA/NFKB1/ADCY1/PRKAA1/ATF2/EHMT1/ADCY2/AKT2/RPS6KB1/ATG5/IRS1/RB1CC1/FOXO3/RPTOR/PIK3R3/ADCY4/ULK1/ADCY7/MTOR/PIK3CB/CREB3L4/PPARGC1A/ADCY5/KL	4.46264518169563
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	124/2531	333/9376	1.37944028580141	FOXO1/COL6A3/COL4A1/LAMA2/THBS1/COL4A2/TCF7L2/AKT3/TNXB/ITGB8/PDGFRB/VWF/ITGA6/HES1/CREB5/LAMB1/ATP6V0A1/COL4A4/IRF1/CCND2/TNC/HES4/TCF7L1/LAMA3/JAG1/PIK3R1/WNT9A/MAML3/ITGA1/EGFR/THBS3/NOTCH3/PTEN/CREB3L2/MAML2/HEYL/UBR4/PARD3/COL4A3/RFNG/PIK3CA/CREBBP/LAMA4/DLG2/PPP2CB/PSEN1/MAGI1/WNT2/NFKB1/MX2/LAMC1/ITGA9/PPP2CA/NOTCH1/SOS2/PPP2R3A/AKT2/FAS/PPP2R2A/RPS6KB1/NFX1/HLA-G/PPP2R2D/PPP2R1B/RAF1/RBL2/CTNNB1/LAMC3/DLG1/RELN/RBPJ/MAPK1/WNT5B/AXIN1/APC/ATR/WNT2B/PPP2R5D/PIK3R3/PPP2R5A/ATP6V1E2/HLA-E/IKBKB/CDKN1B/THBS4/SOS1/CCND3/ITGA7/MTOR/FZD8/PIK3CB/PRKCZ/PTGER4/FZD4/TCF7/CSNK1A1/NOTCH4/ITGA4/ITGB4/COMP/RBL1/VTN/COL6A2/ITGA5/PPP2R3B/CREB3L4/ITGA8/CDK2/TNF/AXIN2/MFNG/FZD3/LFNG/PATJ/TLR3/HES2/ATP6V1C2/WNT11/WNT6/LLGL2/CCNA1/PPP2R2B/HEY1/WNT5A	4.28700780938043
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	64/2531	150/9376	1.580571579086	TCF7L2/AKT3/GADD45B/MYC/BCL2/GADD45G/SMAD3/GADD45A/TCF7L1/PIK3R1/TGFBR1/WNT9A/BRAF/EGFR/TGFBR2/PIK3CA/LRP6/WNT2/POLK/RXRA/SOS2/CTNNA3/TGFB2/AKT2/RPS6KB1/HGF/GAB1/RAF1/CTNNB1/MLH1/MAPK1/FGF7/WNT5B/AXIN1/APC/CTNNA1/LRP5/WNT2B/PIK3R3/ERBB2/ABCB1/CDKN1B/SOS1/MTOR/FZD8/PIK3CB/JUP/FZD4/TCF7/CSNK1A1/FGF1/CTNNA2/CDH1/TGFB3/FGF10/RARB/CDK2/LEF1/AXIN2/FZD3/MET/WNT11/WNT6/WNT5A	4.35852619825357
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	86/2531	216/9376	1.47492573569223	FOS/MAP3K5/AKT3/MAPK10/NFATC2/HSPA1B/HSPA2/JUN/NFATC1/HSPA1A/ROCK2/CAMK2D/BCL2/TLR4/STAT3/EIF2AK3/HSPA6/PIK3R1/JAK2/PPARG/MAP2K3/NFKBIA/CCL3/PPP3CB/RAP1B/ERN1/ATF6/POU2F1/ATF4/PIK3CA/ITPR1/TANK/CCL3L1/CXCL2/NFKB1/NFE2L2/XBP1/RXRA/TNFSF10/AKT2/RAP1A/FAS/MAP2K4/VCAM1/MAPK8/MIB1/MAPK14/TRAF6/CD40/MAPK1/ABCG1/CCL5/VAV3/ABCA1/PPP3CA/CASP7/PIK3R3/APOB/VAV2/HSP90AA1/CD36/OLR1/NFATC3/IKBKB/CAMK2G/NCF1/SRC/HSPD1/PIK3CB/CYP2A7/NLRP3/SELE/CASP9/HSPA1L/POU2F3/MAPK11/TNF/SELP/APOA1/IL18/CYP2A6/CYBB/NCF2/AGER/VAV1/HSP90AB1	4.29387925141247
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	58/2531	133/9376	1.6154808197895	FOXO1/IRS2/INSR/AKT3/GADD45B/MAPK10/KLF2/BCL6/DEPP1/GADD45G/SMAD3/STAT3/SGK1/GADD45A/GABARAPL1/PRKAG2/CCND2/IGF1/IGF1R/PIK3R1/TGFBR1/PLK3/HOMER1/BRAF/EGFR/PTEN/TGFBR2/PRKAB2/SIRT1/PIK3CA/CREBBP/PRKAA1/TNFSF10/SOS2/TGFB2/SETD7/AKT2/IRS1/FOXO3/MAPK8/MAPK14/RAF1/RBL2/MAPK1/PIK3R3/IKBKB/CDKN1B/SOS1/NLK/PIK3CB/IL10/TGFB3/FOXO4/S1PR1/MAPK11/CDK2/IL7R/PLK2	4.34689201951404
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	52/2531	116/9376	1.66062207931988	VCL/PLCG2/ROCK2/GNAI1/PIK3R1/CLDN5/ACTN4/JAM3/AFDN/ROCK1/RAP1B/PTPN11/JAM2/CTNND1/CXCL12/PIK3CA/CXCR4/CTNNA3/PECAM1/RAP1A/VCAM1/MAPK14/CTNNB1/THY1/MYL9/VAV3/CTNNA1/ESAM/CLDN4/ITGB2/PIK3R3/VAV2/PRKCG/NCF1/PIK3CB/CDH5/PTK2B/RHOH/RAPGEF4/CTNNA2/ITGA4/RAPGEF3/CLDN10/MAPK11/ITK/CLDN7/CYBB/NCF2/ITGAL/VAV1/RASSF5/ITGAM	4.35332980682919
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	54/2531	122/9376	1.63968106949239	FOS/IRS2/AKT3/JUNB/SOCS3/MAPK10/PLCG2/SOCS2/CREB5/STAT3/GNAI1/IGFBP3/ADCY3/CSH1/IGF1/PIK3R1/JAK2/MAP2K3/GNAQ/STAT5B/CACNA1C/CREB3L2/GHR/STAT5A/ADCY9/ATF4/PIK3CA/CREBBP/ITPR1/ADCY1/ATF2/SOS2/ADCY2/AKT2/CSH2/MAP2K4/IRS1/MAPK8/MAPK14/RAF1/MAPK1/PIK3R3/ADCY4/PRKCG/ADCY7/SOS1/CACNA1D/MTOR/PIK3CB/SOCS1/MAP3K1/CREB3L4/MAPK11/ADCY5	4.3243780159894
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	69/2531	166/9376	1.53980759069466	IRS2/INSR/AKT3/NFATC2/ADRA2C/NFATC1/RGS2/ROCK2/CREB5/GUCY1A2/GNAI1/EDNRB/SLC8A1/ADCY3/PDE3A/GNAQ/MEF2D/CACNA1C/NPR1/MYLK/PRKCE/CREB3L2/PPP3CB/PPP1R12A/ROCK1/ADCY9/TRPC6/ATF4/GNA13/GUCY1B1/ITPR1/PDE5A/EDNRA/MEF2C/ADCY1/KCNMB1/ATF2/ADCY2/AKT2/SRF/IRS1/GUCY1A1/RAF1/MYL9/MAPK1/PPP1CB/GNA12/ADRA2A/PPP3CA/PLN/ADCY4/NFATC3/ADCY7/ATP2B4/PIK3R5/ADRA1B/CACNA1D/MEF2B/KCNMB2/PDE2A/NPR2/ATP1B2/KCNMB3/PDE3B/CREB3L4/ADCY5/KCNJ8/KNG1/ATP2A3	4.26685810639501
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	58/2531	134/9376	1.60342499277614	ACTG2/PPP1R14A/ACTA2/RAMP1/MYH11/PPP1R12B/ROCK2/GUCY1A2/ADM/CALCRL/ADCY3/PLA2G2A/GNAQ/CACNA1C/NPR1/MYLK/BRAF/PRKCE/PPP1R12A/MYH10/ROCK1/RAMP2/ADCY9/AVPR1A/PLA2G6/ARHGEF12/GNA13/GUCY1B1/ITPR1/CALD1/EDNRA/PLA2G5/ADCY1/PPP1R12C/PRKCH/KCNMB1/ADCY2/GUCY1A1/RAMP3/RAF1/MYL9/MAPK1/PPP1CB/GNA12/ADCY4/PRKCG/ADCY7/EDN1/ADRA1B/CACNA1D/KCNMB2/NPR2/PLA2G4A/KCNMB3/ADCY5/PRKCD/AGT/PRKCQ	4.27796961445713
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	38/2531	78/9376	1.8047391828506	FOS/HLA-DRA/JUN/TLR4/HLA-DPA1/HLA-DPB1/HLA-DRB1/JAK2/NFKBIA/HLA-DQB1/HLA-DQA1/IFNGR1/NFKB1/HLA-DMA/TGFB2/HLA-DRB5/FCGR2A/MAPK14/TRAF6/MAPK1/IFNGR2/ITGB2/HLA-DQA2/HLA-DMB/NCF1/IL10/ITGA4/TGFB3/HLA-DOA/MAPK11/TNF/PTPN6/IFNG/FCGR3A/CYBB/CR1L/NCF2/ITGAM	4.33962959861752
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	35/2531	70/9376	1.85223231924141	LAMA2/HLA-DRA/DMD/SGCD/SGCE/HLA-DPA1/HLA-DPB1/CD55/HLA-DRB1/ABL2/DTNA/SSPN/HLA-DQB1/CAV1/HLA-DQA1/HLA-DMA/SNTB2/HLA-DRB5/HLA-G/CD40/ITGB2/DAG1/HLA-DQA2/HLA-DMB/HLA-E/FYN/SNTB1/CASP9/HLA-DOA/CD80/NOS1/SGCZ/CD86/ITGAL/PRF1	4.35181555719809
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	34/2531	68/9376	1.85223231924141	ZBTB16/TCF7L2/AKT3/RUNX1T1/PIM1/MYC/STAT3/PER2/TCF7L1/PIK3R1/STAT5B/BRAF/STAT5A/PIK3CA/NFKB1/RARA/SOS2/AKT2/RPS6KB1/RAF1/MAPK1/PIK3R3/CSF1R/IKBKB/SOS1/MTOR/PIK3CB/JUP/TCF7/SPI1/LEF1/CCNA1/ITGAM/BCL2A1	4.28873540910146
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	33/2531	66/9376	1.85223231924141	HLA-DRA/RORA/JUN/NFATC1/TLR4/SMAD3/STAT3/HLA-DPA1/HLA-DPB1/HLA-DRB1/IL4R/HLA-DQB1/HLA-DQA1/MAF/IFNGR1/NFKB1/HLA-DMA/TGFB2/HLA-DRB5/GATA3/IFNGR2/HLA-DQA2/HLA-DMB/STAT4/IL10/IL18R1/TGFB3/HLA-DOA/IL2RG/TNF/IL18/IFNG/IL23A	4.22474121714038
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	45/2531	99/9376	1.68384756294673	FOS/AKT3/MAPK10/ESR1/JUN/BCL2/ADCY3/IGF1/IGF1R/JAG1/PIK3R1/BRAF/EGFR/NOTCH3/ADCY9/PIK3CA/ADCY1/NCOR1/NOTCH1/SOS2/ADCY2/AKT2/RPS6KB1/MAPK8/MAPK14/RAF1/CDKN2C/MAPK1/PIK3R3/ADCY4/DLL1/ERBB2/SP1/ADCY7/CDKN1B/SRC/SOS1/MTOR/PIK3CB/HBEGF/NOTCH4/MAPK11/ADCY5/ESR2/DLL4	4.15927951467394
NA	NA	hsa04519	Cadherin signaling	144/2531	404/9376	1.32040323747902	CDH13/TCF7L2/LHFPL6/VCL/MAPK10/DES/LHFPL3/PDGFRB/DAAM1/FGFR1/LATS2/ROCK2/PRICKLE1/TEAD1/STK3/LIMA1/PCDH18/PRICKLE2/MYO1E/TCF7L1/IGF1R/FAT4/MAP2K3/SHOC2/WNT9A/TJP1/AMOTL2/EGFR/ACTN4/NFKBIA/ERBIN/MPDZ/WTIP/AFDN/AMOTL1/ROCK1/CTNND1/RERE/RRAS2/CREBBP/KRT7/VIM/MYO1D/PSEN1/LRP6/MRAS/PDGFRA/TEAD3/WNT2/TAOK3/NFKB1/DAAM2/CDH11/EVL/CTNNA3/WWTR1/MAPK8/MAPK14/ABI2/TEAD4/RAF1/ANKRD6/CTNNB1/MAPK1/PPP1CB/WNT5B/AXIN1/DCHS1/VAV3/APC/CTNNA1/LRP5/PCDH19/WNT2B/NCKAP1/ERBB2/VAV2/FMN1/FLT4/KRT5/IKBKB/CYFIP2/WASF1/DSP/RRAS/GABRB3/YAP1/PKP2/FZD8/PCDHB16/LATS1/CDH5/PTK2B/JUP/ENAH/FZD4/YWHAZ/LIMD1/TCF7/CSNK1A1/CTNNA2/CDH3/TMC1/PCDHB4/KDR/PCDHGB6/PCDHA10/CDH1/MYO1F/CTNND2/PCDHB2/SCN3B/KRT85/GABRR2/PCDHB15/PCDHB7/KRT23/PCDHGC3/CDH23/PCDH17/PCDH1/MAPK11/PCDHGA6/PCDHGB7/NCKAP1L/PCDHB12/PCDHGA5/DCHS2/LEF1/AXIN2/PCDH11Y/CDH12/FZD3/TMC6/TMC4/MET/WNT11/CDH4/CDH8/WNT6/VAV1/GABRG3/KRT34/WNT5A	4.00302157075614
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	38/2531	80/9376	1.75962070327934	AKT3/PLCG2/PDGFRB/IL6R/BCL2/PDGFD/STAT3/IGF1/IGF1R/PIK3R1/JAK2/BRAF/EGFR/PTEN/AXL/PIK3CA/PDGFRA/SOS2/AKT2/RPS6KB1/HGF/FOXO3/GAB1/RAF1/MAPK1/PIK3R3/ERBB2/PRKCG/SRC/SOS1/PDGFB/MTOR/PIK3CB/PDGFC/KDR/NRG1/MET/NRG2	4.14895489380066
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	52/2531	120/9376	1.60526801000922	MAP3K5/AKT3/MAPK10/PLCG2/JUN/CAMK2D/BCL2/RPS6KA2/NTRK1/PIK3R1/BRAF/KIDINS220/NFKBIA/NGF/MAPKAPK2/RAPGEF1/RIPK2/RAP1B/PTPN11/ATF4/PIK3CA/PSEN1/NFKB1/ARHGDIB/SORT1/SOS2/AKT2/RAP1A/IRS1/MAP3K3/FOXO3/NFKBIE/MAPK8/MAPK14/GAB1/RAF1/TRAF6/RPS6KA5/MAPK1/SH2B1/MAP2K5/PIK3R3/IKBKB/CAMK2G/SOS1/PIK3CB/MAP3K1/NGFR/NTRK2/MAPK11/PRKCD/NTRK3	4.05762264419687
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	40/2531	86/9376	1.72300680859666	LAMA2/TCF7L2/CACNB2/ITGB8/DES/DMD/ITGA6/SGCD/SGCE/SLC8A1/TCF7L1/ITGA1/CACNA1C/DTNA/SSPN/SNTB2/ITGA9/CTNNA3/LMNA/CTNNB1/CTNNA1/DAG1/DSP/ITGA7/SNTB1/PKP2/CACNA1D/JUP/TCF7/CTNNA2/RYR2/ITGA4/ITGB4/CACNB1/ITGA5/ITGA8/LEF1/NOS1/SGCZ/ATP2A3	4.09570567854643
Organismal Systems	Immune system	hsa04611	Platelet activation	54/2531	126/9376	1.58762770220692	AKT3/TLN2/STIM1/PLCG2/VWF/ROCK2/RASGRP2/GUCY1A2/GNAI1/F2R/ADCY3/PIK3R1/GNAQ/APBB1IP/MYLK/PPP1R12A/ROCK1/ADCY9/RAP1B/PIK3CA/FCER1G/SNAP23/ARHGEF12/GNA13/GUCY1B1/ITPR1/ADCY1/ADCY2/AKT2/RAP1A/LCP2/GP1BB/FCGR2A/MAPK14/GUCY1A1/MAPK1/PPP1CB/PIK3R3/ADCY4/FERMT3/P2RY1/ADCY7/PIK3R5/SRC/FYN/PIK3CB/PRKCZ/PLA2G4A/MAPK11/ADCY5/ADAMTS13/TBXA2R/RASGRP1/SYK	4.03795664841317
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	37/2531	78/9376	1.7572460464598	INPP4B/PLCG2/IMPA2/ITPKC/PLCE1/ITPKB/INPP5A/PTEN/IPMK/ITPK1/INPP4A/PIP4K2A/PLCH1/MTMR3/PIK3CA/PIP5K1C/INPP5F/IP6K2/PI4KA/INPP5B/ALDH6A1/MTMR1/MTM1/PLCD3/OCRL/IP6K1/PIKFYVE/INPP5D/FIG4/PIK3CB/PLCD1/PIK3C2B/PIP5K1B/SYNJ1/IP6K3/INPP5E/PIK3C2G	4.08351851964328
Human Diseases	Immune disease	hsa05330	Allograft rejection	22/2531	39/9376	2.08969800119543	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DRB5/FAS/HLA-G/CD40/HLA-DQA2/HLA-DMB/HLA-E/GZMB/IL10/HLA-DOA/TNF/IFNG/CD80/CD86/PRF1	4.14648179471914
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	44/2531	98/9376	1.66322902135963	PLPP3/GSN/AKT3/PLCG2/GAB2/PIK3R1/PRKCE/ASAP3/WASF2/PLA2G6/PIK3CA/DOCK1/ASAP2/AKT2/PIP5K1C/RPS6KB1/FCGR2A/CFL2/MYO10/RAF1/ASAP1/MAPK1/VAV3/PTPRC/PIK3R3/VAV2/PRKCG/WASF1/NCF1/PLPP1/INPP5D/PLD2/PIK3CB/AMPH/FCGR2B/PLA2G4A/PIP5K1B/PRKCD/HCK/FCGR3A/VAV1/WAS/SCIN/SYK	4.01323286387439
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	72/2531	181/9376	1.47359919320863	AKT3/HLA-DRA/MAPK10/CAMK2D/BCL2/TLR4/CD74/ATP6V0A1/HLA-DPA1/HLA-DPB1/HLA-DRB1/JAK2/PLK3/PLA2R1/PPP3CB/KSR1/EEA1/HLA-DQB1/RIPK2/FCER1G/CREBBP/ARHGEF12/HLA-DQA1/IFNGR1/NFKB1/HLA-DMA/NFYB/MALT1/CTSS/LSP1/TGFB2/AKT2/HLA-DRB5/FCGR2A/MAPK8/MAPK14/RAB5A/RAF1/TRAF6/MAPK1/MRC1/IFNGR2/PPP3CA/CEBPG/ITGB2/HLA-DQA2/HLA-DMB/NFYC/CAMK2G/CIITA/SRC/HSPD1/CARD9/RAB7A/FCGR2B/IL10/TGFB3/CASP9/HLA-DOA/IL10RA/MAPK11/CORO1A/TNF/IL18/IFNG/IL23A/FCGR3A/CR1L/CLEC7A/CEBPB/SYK/ITGAM	3.9121847791903
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	64/2531	157/9376	1.51010023479554	FOXO1/ZFP36L2/AKT3/HIPK3/GADD45B/NFATC2/ZFP36L1/MYC/NFATC1/NBN/GADD45G/SMAD3/GADD45A/SERPINE1/IGFBP3/CCND2/PIK3R1/TGFBR1/MAP2K3/ETS1/PTEN/TGFBR2/PPP3CB/MAPKAPK2/FBXW11/CHEK2/MCU/RRAS2/HIPK1/SIRT1/PIK3CA/ITPR1/MRAS/NFKB1/TGFB2/AKT2/RAD9A/FOXO3/HLA-G/MAPK14/RAF1/RBL2/MRE11/MAPK1/PPP1CB/BTRC/ATR/PPP3CA/PIK3R3/HLA-E/NFATC3/RRAS/CCND3/CACNA1D/MTOR/PIK3CB/E2F5/TGFB3/RBL1/MAPK11/CDK2/LIN52/RASSF5/CCNA1	3.91929927068585
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	44/2531	99/9376	1.64642872821458	MAPK10/PLCG2/CAMK2D/NTRK1/ADCY3/IGF1/PIK3R1/MAP2K3/GNAQ/PRKCE/NGF/ADCY9/PLA2G6/PIK3CA/ITPR1/ADCY1/PRKCH/IL1R1/ADCY2/IL1RAP/MAPK8/HTR2B/MAPK14/HTR2A/PTGER2/HRH1/PPP1CB/PIK3R3/ADCY4/PRKCG/CAMK2G/ADCY7/ASIC2/SRC/PIK3CB/PTGER4/PLA2G4A/TRPV1/MAPK11/ADCY5/PRKCD/KNG1/TRPV3/PRKCQ	3.93169167025177
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	58/2531	140/9376	1.53470677880002	EGR1/CCN2/AKT3/KLF2/ACTA2/SMAD3/GNAI1/SERPINE1/SLC8A1/PRKAG2/ADCY3/PLAT/JAG1/TGFBR1/GNAQ/MEF2D/MYLK/PRKCE/NOTCH3/HDAC4/ADCY9/GNG4/PRKAB2/RRAS2/GNA13/ITPR1/MRAS/MAP1LC3A/MEF2C/ADCY1/PRKAA1/ADCY2/AKT2/RPS6KB1/GNB4/GNB5/RAF1/MAP1LC3B/MYL3/MAPK1/HDAC5/ADCY4/GNG7/ADCY7/PIK3R5/RRAS/RYR3/MTOR/MEF2B/MAP1LC3C/RYR2/CDH1/PDE3B/PPARGC1A/ADCY5/APLNR/NOS1/RYR1	3.87599073452995
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	109/2531	298/9376	1.35498874360613	PRLR/CCL21/ACVRL1/IL6R/IL15/CCL14/CSF1/IL1RL1/BMP6/CCL4/CSH1/TNFRSF1B/TGFBR1/IL15RA/TNFSF12/CLCF1/LIFR/IL4R/CCL4L2/GHR/CCL3/NGF/TGFBR2/RELL1/CXCL12/CCL3L1/IFNGR1/CXCL2/GDF7/IL16/CSF3/CXCR4/CXCL16/TNFSF10/IL1R1/TGFB2/FAS/CSH2/OSMR/CXCL13/CCL13/ACKR4/EBI3/IL1RAP/ACVR2A/INHBB/TNFRSF14/CD40/IL1RL2/CCL5/CTF1/BMPR2/IFNGR2/CSF3R/CSF2RA/IL17RC/TNFSF13/IL11RA/TNFRSF8/CSF1R/BMPR1A/CSF2RB/CCL8/CCL26/IL34/IL17RE/CD4/TNFRSF19/IL1R2/IL3RA/CXCL9/XCL2/IL7/IL6ST/IL17D/IL19/IL2RB/IL2RA/IL10/IL18R1/BMP4/XCL1/LEPR/NGFR/BMP8A/CX3CL1/CCL18/TGFB3/IL10RA/BMPR1B/IL2RG/TNF/IL17B/TNFSF15/THPO/IL7R/IL18/EDA/IFNG/TNFRSF4/IL23A/INHA/CCR10/ACVR2B/OSM/TNFSF8/IL20RA/CCL23/BMP7	3.78680210220969
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	39/2531	86/9376	1.67993163838174	AKT3/CBLB/MAPK10/PLCG2/MYC/JUN/CAMK2D/PIK3R1/ABL2/PAK3/STAT5B/BRAF/EGFR/STAT5A/PIK3CA/SOS2/AKT2/RPS6KB1/MAP2K4/MAPK8/GAB1/RAF1/CBL/PAK2/NRG3/MAPK1/PIK3R3/ERBB2/PRKCG/CAMK2G/CDKN1B/SRC/SOS1/MTOR/PIK3CB/NCK2/HBEGF/NRG1/NRG2	3.85169245881477
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	93/2531	250/9376	1.37806084551561	CBLB/HSPA1B/EPN2/HSPA1A/SMAD3/WIPF1/IGF1R/HSPA6/EPS15/TGFBR1/CYTH3/EGFR/TGFBR2/AP2B1/ASAP3/EEA1/SPART/GRK5/WASL/WASHC4/PARD3/CAV1/CYTH1/WIPF3/IST1/ARF5/ITCH/PDGFRA/VPS37B/ARFGAP3/RUFY2/CHMP4B/WASHC1/EHD1/ASAP2/WASHC3/RAB11FIP2/VPS36/ACAP1/SNX1/AP2A2/SMURF2/CXCR4/RABEP1/SMAP1/IQSEC1/PIP5K1C/SMURF1/HLA-G/CLTB/RAB5A/STAM2/CBL/ASAP1/STAM/TRAF6/ARFGEF1/SNX6/PDCD6IP/CLTCL1/RAB11FIP3/WASHC2A/AGAP3/TFRC/SMAP2/EHD4/GRK4/DNM3/FOLR2/HLA-E/SRC/MVB12B/SNX4/GBF1/GRK2/ARRB2/PLD2/RAB11FIP1/RAB7A/PRKCZ/ARAP2/AMPH/CHMP6/IL2RB/IL2RA/RAB11A/HSPA1L/PIP5K1B/IL2RG/GRK3/KIF5C/RAB11FIP4/CYTH4	3.68414282143211
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	34/2531	73/9376	1.7253670918961	AKT3/GADD45B/PLCG2/GADD45G/STAT3/GADD45A/PIK3R1/STAT5B/EML4/BRAF/EGFR/STAT5A/PIK3CA/POLK/RASSF1/RXRA/SOS2/AKT2/HGF/FOXO3/RAF1/MAPK1/PIK3R3/FHIT/ERBB2/PRKCG/SOS1/PIK3CB/CASP9/RARB/KIF5C/MET/JAK3/RASSF5	3.78314295942757
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	51/2531	122/9376	1.54858767674282	FOXO1/AKT3/MED13L/PLCG2/ESR1/MYC/PLCE1/PIK3R1/RCAN1/NCOA1/NOTCH3/NCOA2/KAT2B/PIK3CA/CREBBP/DIO3/NCOR1/SIN3A/RXRA/NOTCH1/DIO2/AKT2/TBC1D4/RAF1/CTNNB1/SLC16A10/MAPK1/MED13/PLCD3/PLN/PIK3R3/KAT2A/PRKCG/SRC/THRB/MED30/MTOR/PIK3CB/SLC16A2/SLC2A1/MED14/PLCD1/NOTCH4/BMP4/MED12L/ATP1B2/CASP9/RCAN2/PFKFB2/DIO1/ATP2A3	3.70856760077616
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	52/2531	125/9376	1.54105728960885	CERS6/MAP3K5/AKT3/MAPK10/ROCK2/BCL2/GNAI1/GAB2/PIK3R1/GNAQ/S1PR3/SPTLC2/PRKCE/PTEN/ROCK1/SGMS2/PIK3CA/FCER1G/GNA13/PPP2CB/NFKB1/PPP2CA/PPP2R3A/AKT2/PPP2R2A/SGPP1/MAPK8/PPP2R2D/MAPK14/S1PR2/CERS4/PPP2R1B/RAF1/MAPK1/GNA12/ACER2/PPP2R5D/PIK3R3/PPP2R5A/PRKCG/FYN/PLD2/PIK3CB/PRKCZ/SGPL1/SGMS1/PPP2R3B/S1PR1/MAPK11/TNF/KNG1/PPP2R2B	3.70295899760182
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	56/2531	137/9376	1.51423372083969	FOS/MCL1/MAP3K5/AKT3/GADD45B/MAPK10/JUN/CTSK/CFLAR/CTSH/BCL2/GADD45G/PTPN13/GADD45A/NTRK1/EIF2AK3/PIK3R1/DAB2IP/NFKBIA/NGF/TUBA1A/ERN1/ATF4/PIK3CA/ITPR1/RIPK1/MAP3K14/NFKB1/CTSS/BIRC2/TNFSF10/AKT2/FAS/LMNA/MAPK8/CTSC/RAF1/MAPK1/TRAF1/CASP7/PIK3R3/IKBKB/CSF2RB/BBC3/PMAIP1/PIK3CB/IL3RA/SEPTIN4/GZMB/CASP9/CTSW/TNF/TUBA3E/DFFB/PRF1/BCL2A1	3.68683190091462
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	45/2531	105/9376	1.58762770220692	LAMA2/CACNB2/ITGB8/DES/DMD/ITGA6/SGCD/SGCE/SLC8A1/ADCY3/IGF1/ITGA1/CACNA1C/DTNA/SSPN/ADCY9/TPM1/ADCY1/SNTB2/ITGA9/ADCY2/TGFB2/LMNA/MYL3/PLN/ADCY4/DAG1/ADCY7/TTN/ITGA7/SNTB1/CACNA1D/RYR2/ITGA4/ITGB4/TGFB3/CACNB1/ITGA5/ITGA8/ADCY5/TNF/AGT/NOS1/SGCZ/ATP2A3	3.68195608935317
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	23/2531	44/9376	1.93642469738874	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DRB5/FAS/HLA-G/PTPRN2/HLA-DQA2/HLA-DMB/HLA-E/HSPD1/GZMB/HLA-DOA/TNF/IFNG/CD80/CD86/ICA1/PRF1	3.7857925917406
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	33/2531	71/9376	1.72179342352018	FOS/PRLR/AKT3/SOCS3/MAPK10/SOCS2/ESR1/STAT3/IRF1/CCND2/PIK3R1/JAK2/STAT5B/STAT5A/PIK3CA/NFKB1/SOS2/AKT2/CISH/FOXO3/MAPK8/MAPK14/RAF1/MAPK1/PIK3R3/SRC/SOS1/CGA/PIK3CB/SOCS1/LHCGR/MAPK11/ESR2	3.71217884049641
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	17/2531	29/9376	2.17158271911061	LATS2/TEAD1/STK3/FAT4/WTIP/FRMD6/TEAD3/RASSF1/RASSF4/RASSF2/WWTR1/TEAD4/DCHS1/YAP1/LATS1/LIMD1/DCHS2	3.84220753480273
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	56/2531	138/9376	1.50326101271766	FOS/AKT3/MAPK10/NFATC2/JUN/NFATC1/ROCK2/TLR4/RPS6KA2/WIPF1/ELMO1/PIK3R1/MAP2K3/GNAQ/NFKBIA/WASF2/WASL/ROCK1/ARHGEF7/WIPF3/PIK3CA/ARHGEF12/NFKB1/DOCK1/PKN2/AKT2/PIP5K1C/LCP2/MAP2K4/FCGR2A/MAPK8/MAPK14/TRAF6/MAPK1/VAV3/PIK3R3/VAV2/NFATC3/IKBKB/SRC/CD4/PIK3CB/PTK2B/FYB1/NLRP3/ARHGEF28/IL10/ITGA4/ITGA5/PIP5K1B/MAPK11/TNF/LCK/IL18/VAV1/WAS	3.6215028890657
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	30/2531	63/9376	1.76403078022991	PRDM2/DLST/ALDH7A1/AASS/SETDB2/KMT2C/DOT1L/EZH1/HADH/SETD2/KMT5B/EHMT1/SETD7/KMT2E/KMT5A/CAMKMT/NSD3/DHTKD1/KMT2B/MECOM/NSD2/ASH1L/TMLHE/EZH2/NSD1/PRDM6/HYKK/SETMAR/AADAT/EHHADH	3.69982611055104
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	48/2531	115/9376	1.54621132736674	FOS/EGR1/AKAP13/FGFR1/JUND/BCL2/CREB5/SGK1/GNAI1/ADCY3/GNAQ/MEF2D/BRAF/EGFR/CREB3L2/ADCY9/ATF4/GNA13/PTH1R/ITPR1/NR4A2/LRP6/MEF2C/ADCY1/RXRA/ATF2/ADCY2/MAFB/GATA3/STK39/RAF1/WNK1/MAPK1/GNA12/LRP5/ADCY4/SP1/PRKCG/ADCY7/ARRB2/MMP17/PLD2/HBEGF/WNK2/CREB3L4/ADCY5/GCM1/KL	3.58365064029768
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	53/2531	130/9376	1.51028173722761	FOS/COL4A1/COL4A2/AKT3/MAPK10/ACTA2/JUN/CREB5/COL4A4/GNAI1/EDNRB/ADCY3/PIK3R1/TGFBR1/EGFR/NFKBIA/CREB3L2/TGFBR2/ADCY9/GNG4/COL4A3/ATF4/PIK3CA/NFKB1/ADCY1/ATF2/SOS2/ADCY2/AKT2/MAP2K4/GNB4/MAPK8/GNB5/MAPK14/RXFP1/GNAO1/RAF1/MAPK1/PIK3R3/ADCY4/GNG7/ADCY7/SRC/EDN1/SOS1/ARRB2/PIK3CB/PRKCZ/CREB3L4/MAPK11/ADCY5/GNA15/NOS1	3.56245790692864
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	39/2531	89/9376	1.62330472922281	COL6A3/COL4A1/LAMA2/THBS1/COL4A2/TNXB/ITGB8/VWF/ITGA6/SDC4/LAMB1/COL4A4/TNC/LAMA3/CD44/ITGA1/THBS3/COL4A3/LAMA4/LAMC1/ITGA9/HSPG2/NPNT/GP1BB/LAMC3/RELN/DAG1/CD36/THBS4/ITGA7/ITGA4/ITGB4/COMP/VTN/COL6A2/ITGA5/ITGA8/SV2B/FREM1	3.59254889079343
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	42/2531	98/9376	1.58762770220692	INPP4B/PLCG2/IMPA2/ITPKC/PLCE1/ITPKB/INPP5A/PIK3R1/PTEN/IPMK/ITPK1/INPP4A/PIP4K2A/MTMR3/PIK3CA/ITPR1/PIP5K1C/INPP5F/DGKH/IP6K2/PI4KA/INPP5B/MTMR1/MTM1/CDS2/PLCD3/PIK3R3/DGKA/OCRL/PRKCG/IP6K1/PIKFYVE/INPP5D/PIK3CB/PLCD1/PIK3C2B/DGKB/PIP5K1B/SYNJ1/IP6K3/INPP5E/PIK3C2G	3.55576539968845
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	46/2531	110/9376	1.54913975791099	INSR/AKT3/FLT1/PLCG2/IL6R/CAMK2D/BCL2/TLR4/STAT3/EPAS1/ANGPT1/SERPINE1/IGF1/IGF1R/PIK3R1/EGLN3/EGFR/PIK3CA/TEK/CREBBP/IFNGR1/NFKB1/PFKFB3/ANGPT2/AKT2/RPS6KB1/ARNT/MAPK1/TF/TFRC/IFNGR2/PIK3R3/ERBB2/PRKCG/CAMK2G/CDKN1B/MKNK2/EDN1/MTOR/PIK3CB/SLC2A1/ALDOB/ENO3/IFNG/CYBB/LDHC	3.52271952982291
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	27/2531	56/9376	1.78608116498278	BOC/GAS1/BCL2/CCND2/GLI3/SCUBE2/FBXW11/CSNK1G3/SMURF2/SMURF1/MGRN1/EVC2/MOSMO/CUL3/HHAT/BTRC/SPOP/DISP1/SPOPL/GRK2/ARRB2/PTCH2/PTCH1/CSNK1A1/EFCAB7/GRK3/LRP2	3.58755388008149
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	32/2531	70/9376	1.69346954902071	AKT3/JUN/EPAS1/PIK3R1/PAK3/EGLN3/BRAF/ETS1/RAPGEF1/RAP1B/PTPN11/PIK3CA/CREBBP/TFE3/SOS2/TGFB2/AKT2/RAP1A/HGF/ARNT/GAB1/RAF1/PAK2/MAPK1/PIK3R3/SOS1/PDGFB/PIK3CB/SLC2A1/TGFB3/ARNT2/MET	3.54111373593266
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	42/2531	99/9376	1.57159105875028	LAMA2/CACNB2/ITGB8/DES/DMD/ITGA6/SGCD/SGCE/SLC8A1/PRKAG2/IGF1/ITGA1/CACNA1C/DTNA/SSPN/ACE/PRKAB2/TPM1/SNTB2/ITGA9/PRKAA1/TGFB2/LMNA/MYL3/DAG1/TTN/EDN1/ITGA7/SNTB1/CACNA1D/RYR2/ITGA4/ITGB4/TGFB3/CACNB1/ITGA5/ITGA8/TNF/AGT/NOS1/SGCZ/ATP2A3	3.47651598140743
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	63/2531	163/9376	1.43178694616207	FOS/AKT3/MAPK10/NFATC2/MYC/JUN/NFATC1/BCL2/CREB5/TLR4/SMAD3/STAT3/EGR3/PIK3R1/JAK2/TGFBR1/MAP2K3/STAT5B/BRAF/NFKBIA/CREB3L2/TGFBR2/STAT5A/DDX3X/ATF4/PIK3CA/CREBBP/NFKB1/ATF2/SOS2/TGFB2/AKT2/FAS/MAP2K4/HSPG2/MAPK8/MAPK14/RAF1/TRAF6/MAPK1/PIK3R3/MAVS/PRKCG/NFATC3/IKBKB/SRC/SOS1/PIK3CB/PTK2B/STAT4/EGR2/YWHAZ/MAP3K1/TGFB3/SLC10A1/CASP9/CREB3L4/MAPK11/CDK2/TNF/TLR3/JAK3/CCNA1	3.38148729260009
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	60/2531	154/9376	1.4432979110972	FOS/CACNB2/NFATC2/JUN/NFATC1/PPP1R12B/RGS2/ROCK2/CAMK2D/GUCY1A2/GNAI1/PRKAG2/ADCY3/GNAQ/CACNA1C/RCAN1/NPR1/MYLK/EGFR/PPP3CB/PPP1R12A/ROCK1/ADCY9/CAMKK2/CAMK1/PRKAB2/GUCY1B1/OXTR/ITPR1/MEF2C/ADCY1/PPP1R12C/PRKAA1/ADCY2/GUCY1A1/GNAO1/RAF1/MYL9/MAPK1/PPP1CB/PPP3CA/MAP2K5/ADCY4/CAMK1G/PRKCG/NFATC3/CAMK2G/ADCY7/PIK3R5/SRC/RYR3/CACNA1D/OXT/RYR2/NPR2/PLA2G4A/CACNB1/ADCY5/KCNJ2/RYR1	3.37278354860734
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	39/2531	91/9376	1.58762770220692	FOS/AKT3/NFATC2/PLCG2/JUN/NFATC1/IFITM1/PIK3R1/NFKBIA/PPP3CB/PIK3CA/NFKB1/MALT1/SOS2/AKT2/DAPP1/NFKBIE/RAF1/MAPK1/VAV3/PPP3CA/PIK3R3/VAV2/NFATC3/IKBKB/SOS1/RASGRP3/INPP5D/PIK3CB/FCGR2B/BANK1/CD22/PTPN6/PIK3AP1/LILRB2/LILRB4/VAV1/LILRB5/SYK	3.42512943441409
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	56/2531	142/9376	1.46091563207773	FOS/SDC2/DUSP1/MAP3K5/AKT3/MAPK10/KLF2/JUN/BCL2/SDC4/PLAT/PIK3R1/CAV1/PIK3CA/GSTM5/NFKB1/MEF2C/NFE2L2/GSTT2B/PRKAA1/IL1R1/AKT2/PECAM1/MAP2K4/VCAM1/ACVR2A/MAPK8/MAPK14/CTNNB1/BMPR2/GSTA4/MAP2K5/PIK3R3/HSP90AA1/IKBKB/BMPR1A/NCF1/SRC/EDN1/PDGFB/GSTM2/PIK3CB/IL1R2/CDH5/PRKCZ/BMP4/KDR/SELE/BMPR1B/MAPK11/TNF/IFNG/NCF2/ACVR2B/GSTA1/HSP90AB1	3.36523703083719
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	60/2531	155/9376	1.43398631167077	PBX1/TCF7L2/NR4A1/CAMK2D/CREB5/GNAI1/ADCY3/TCF7L1/WNT9A/GNAQ/CACNA1C/PDE8B/BRAF/EGFR/CREB3L2/ADCY9/RAP1B/PDE8A/ATF4/ITPR1/WNT2/ADCY1/RASD1/ATF2/ADCY2/RAP1A/ARNT/CTNNB1/CYP11A1/CDKN2C/MAPK1/WNT5B/AXIN1/APC/WNT2B/ADCY4/SP1/CAMK2G/ADCY7/CDKN1B/CACNA1D/FZD8/HSD3B1/FZD4/CACNA1H/TCF7/RBBP5/POMC/KCNK3/CREB3L4/CDK2/ADCY5/LEF1/AXIN2/AGT/FZD3/PDE11A/WNT11/WNT6/WNT5A	3.31282011360431
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	40/2531	95/9376	1.55977458462434	FOS/FLT1/HLA-DRA/JUN/CTSK/IL15/TLR4/ATP6V0A1/ANGPT1/CSF1/HLA-DPA1/HLA-DPB1/HLA-DRB1/CCL3/HLA-DQB1/CXCL12/TEK/HLA-DQA1/CCL3L1/CXCL2/HLA-DMA/TGFB2/HLA-DRB5/CCL5/ITGB2/TNFSF13/HLA-DQA2/HLA-DMB/ATP6V1E2/ACP5/TGFB3/HLA-DOA/TNF/IL18/IFNG/CD80/IL23A/CD86/ATP6V1C2/ITGAL	3.33443746703243
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	18/2531	34/9376	1.96118716154972	RORB/RORA/CRY1/PER1/CRY2/PRKAG2/PER2/NFIL3/NR1D1/NR1D2/FBXW11/PRKAB2/FBXL3/PRKAA1/PER3/BTRC/CLOCK/BHLHE40	3.41407040538288
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	41/2531	99/9376	1.53417222401813	FOS/PLPP3/AKT3/MAPK10/PDGFRB/JUN/GPCPD1/PDGFD/PIK3R1/SLC44A2/EGFR/WASF2/PIK3CA/PDGFRA/CHKA/SOS2/AKT2/PIP5K1C/RPS6KB1/MAPK8/DGKH/RAF1/CHPT1/MAPK1/PIK3R3/DGKA/SP1/SLC44A3/PRKCG/WASF1/PLPP1/SOS1/PDGFB/PLD2/MTOR/PIK3CB/PDGFC/DGKB/PLA2G4A/PIP5K1B/WAS	3.24892813698527
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	31/2531	70/9376	1.64054862561382	IRS2/AKT3/SOCS3/MAPK10/STAT3/ACSL1/PRKAG2/TNFRSF1B/JAK2/ACACB/NFKBIA/CAMKK2/PTPN11/PRKAB2/NFKB1/RXRA/PRKAA1/AKT2/IRS1/NFKBIE/MAPK8/PPARA/CD36/IKBKB/MTOR/SLC2A1/LEPR/POMC/PPARGC1A/TNF/PRKCQ	3.27087979551085
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	64/2531	170/9376	1.39462198154647	TCF7L2/AKT3/GADD45B/PLCG2/MYC/GADD45G/SMAD3/GADD45A/TCF7L1/IGF1R/PIK3R1/TGFBR1/WNT9A/BRAF/EGFR/PTEN/TGFBR2/SMARCA2/PIK3CA/LRP6/GSTM5/WNT2/POLK/NFE2L2/GSTT2B/SOS2/TGFB2/AKT2/SMARCC1/PHF10/RPS6KB1/ARID1B/HGF/ARID1A/GAB1/RAF1/CTNNB1/MAPK1/WNT5B/AXIN1/APC/LRP5/GSTA4/WNT2B/PIK3R3/IGF2/PRKCG/SOS1/MTOR/FZD8/GSTM2/PIK3CB/FZD4/TCF7/CSNK1A1/TGFB3/LEF1/AXIN2/FZD3/MET/GSTA1/WNT11/WNT6/WNT5A	3.15729551705516
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	90/2531	254/9376	1.31260558056478	FLT1/STIM1/NFATC2/PDE1A/PLCG2/PDGFRB/ITPKC/NFATC1/FGFR1/CAMK2D/PDGFD/PLCE1/EDNRB/SLC8A1/NTRK1/ITPKB/F2R/ADCY3/GNA14/GNAQ/PTGER3/CACNA1C/MYLK/EGFR/NGF/PPP3CB/ADCY9/CAMK1/MCU/AVPR1A/OXTR/ITPR1/PDGFRA/EDNRA/ADCY1/CXCR4/P2RX4/ADCY2/HGF/HTR2B/GNAL/HTR2A/PHKB/HRH1/FGF7/PPP3CA/PLCD3/PLN/ADCY4/ERBB2/FLT4/CAMK1G/PRKCG/NFATC3/CAMK2G/ADCY7/ATP2B4/P2RX7/RYR3/ADRA1B/TPCN1/PDGFB/CACNA1D/PTK2B/TPCN2/CHRM5/CACNA1H/PLCD1/FGF1/PHKA2/PDGFC/RYR2/KDR/LHCGR/GRM5/NTRK2/FGF10/CYSLTR2/PHKG1/TACR1/GNA15/NOS1/MET/CHRM3/TBXA2R/ATP2A3/RYR1/NTRK3/PDE1C/TNNC2	3.07123844533824
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	48/2531	122/9376	1.45749428399324	FOXO1/IRS2/INSR/AKT3/CREB5/PRKAG2/CAB39L/IGF1/IGF1R/PIK3R1/PPARG/TBC1D1/ACACB/CREB3L2/CAMKK2/PRKAB2/SIRT1/PIK3CA/PPP2CB/PFKFB3/PPP2CA/PRKAA1/PPP2R3A/AKT2/PPP2R2A/RPS6KB1/IRS1/FOXO3/PPP2R2D/PPP2R1B/RAB14/RPTOR/CAB39/PPP2R5D/PIK3R3/PPP2R5A/ULK1/CD36/MTOR/PIK3CB/LEPR/PPP2R3B/CREB3L4/PPARGC1A/PFKFB2/FBP1/CCNA1/PPP2R2B	3.09275718556292
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	30/2531	69/9376	1.61063679934035	AKT3/MAPK10/PLCG2/GAB2/PIK3R1/MAP2K3/PIK3CA/FCER1G/SOS2/AKT2/LCP2/MAP2K4/MAPK8/MAPK14/RAF1/MAPK1/VAV3/PIK3R3/VAV2/FYN/SOS1/INPP5D/ALOX5AP/PIK3CB/ALOX5/PLA2G4A/MAPK11/TNF/VAV1/SYK	3.09562001507753
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	23/2531	50/9376	1.70405373370209	HLA-DRA/IL15/HLA-DPA1/HLA-DPB1/HLA-DRB1/IL15RA/HLA-DQB1/CXCL12/HLA-DQA1/MAP3K14/HLA-DMA/CXCR4/HLA-DRB5/CD40/TNFSF13/HLA-DQA2/HLA-DMB/IL10/ITGA4/HLA-DOA/CD80/CCR10/CD86	3.0352054063228
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	41/2531	103/9376	1.47459272017277	COL4A1/LAMA2/COL4A2/VCL/HSPB1/LAMB1/TLR4/COL4A4/LAMA3/PIK3R1/GNA14/GNAQ/SERPINB9/ACTN4/SERPINB6/COL4A3/PIK3CA/LAMA4/CXCL2/NFKB1/ADCY1/LAMC1/IL1R1/TGFB2/GNAL/RAB5A/LAMC3/ITGB2/PIK3R3/PRKCG/PIK3CB/IL1R2/RAB7A/IL10/SERPINB10/TGFB3/ARG1/TNF/IFNG/GNA15/ITGAM	2.94492703698163
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	40/2531	100/9376	1.48178585539313	CCL21/IL6R/CCL14/CSF1/CCL4/TNFRSF1B/CCL4L2/CCL3/CXCL12/CCL3L1/CXCL2/CXCR4/TNFSF10/CXCL13/CCL13/ACKR4/TNFRSF14/CCL5/CSF1R/CCL8/CCL26/IL34/CXCL9/XCL2/IL6ST/IL19/IL2RB/IL2RA/IL10/IL18R1/XCL1/CX3CL1/CCL18/IL10RA/IL2RG/TNF/IL18/CCR10/IL20RA/CCL23	2.9452262331696
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	36/2531	88/9376	1.51546280665206	CFD/A2M/CFH/SERPING1/VWF/C1QA/C1QB/SERPINE1/TFPI/MASP1/F2R/PLAT/CD55/C7/PLAU/SERPINF2/C1R/C5AR1/C1QC/C2/F10/PROS1/CD46/F2RL2/ITGB2/VSIG4/F3/SERPINA1/F8/VTN/C5/KNG1/C6/CR1L/ITGAM/CD59	2.95408203401173
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	62/2531	169/9376	1.35903436441381	IRS2/AKT3/MAPK10/UVRAG/CFLAR/BCL2/GABARAPL1/EIF2AK3/IGF1R/PIK3R1/CALCOCO2/WDFY3/DEPTOR/PTEN/CAMKK2/ERN1/VMP1/MTMR3/RRAS2/PIK3CA/ITPR1/TANK/PPP2CB/MRAS/MAP1LC3A/DAPK1/STX17/WDR41/PPP2CA/PRKAA1/AKT2/RPS6KB1/ATG5/IRS1/RB1CC1/ULK2/RUBCN/STX7/TP53INP2/MAPK8/RAF1/ATG10/TRAF6/MAP1LC3B/EPG5/MAPK1/RPTOR/C9orf72/PIK3R3/ULK1/DAPK2/ATG4C/RRAS/MTOR/PIK3CB/RAB7A/MAP1LC3C/ATG16L1/HMGB1/RAB33B/PRKCD/PRKCQ	2.86394902433528
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	26/2531	59/9376	1.63247594238226	IRS2/INSR/AKT3/MGLL/FABP4/GNAI1/ADCY3/PIK3R1/ABHD5/PTGER3/NPR1/ADCY9/PIK3CA/ADCY1/ADCY2/AKT2/IRS1/PIK3R3/ADCY4/ADCY7/TSHR/NPY1R/CGA/PIK3CB/PDE3B/ADCY5	2.96330909140238
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	52/2531	138/9376	1.39588522609497	FOXO1/IRS2/INSR/SORBS1/AKT3/CBLB/SOCS3/MAPK10/SOCS2/PRKAG2/PTPN1/INPP5A/PIK3R1/ACACB/BRAF/RHOQ/RAPGEF1/FLOT1/PPP1R3B/PRKAB2/PIK3CA/TRIP10/PRKAA1/SOS2/AKT2/RPS6KB1/IRS1/MAPK8/PYGL/RAF1/CBL/PHKB/PRKAR2B/MAPK1/PPP1CB/RPTOR/PIK3R3/PYGM/IKBKB/MKNK2/SOS1/MTOR/PIK3CB/PRKCZ/SOCS1/PHKA2/PTPRF/PDE3B/PPARGC1A/FLOT2/PHKG1/FBP1	2.84881891068661
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	32/2531	77/9376	1.53951777183701	AKT3/GADD45B/MYC/GADD45G/SMAD3/GADD45A/GAB2/PIK3R1/TGFBR1/STAT5B/BRAF/CTBP2/NFKBIA/TGFBR2/STAT5A/PTPN11/PIK3CA/NFKB1/POLK/SOS2/TGFB2/AKT2/RAF1/CBL/MAPK1/PIK3R3/MECOM/IKBKB/CDKN1B/SOS1/PIK3CB/TGFB3	2.89053330875865
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	18/2531	37/9376	1.80217198628894	HBB/HBA2/HBA1/GNAQ/APOL1/LAMA4/FAS/VCAM1/PRKCG/IL10/IDO2/SELE/TNF/APOA1/IL18/IFNG/KNG1/IDO1	2.97278259905965
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	65/2531	180/9376	1.33772334167435	AKT3/HLA-DRA/SOCS3/PILRA/BCL2/CD74/HLA-DPA1/HLA-DPB1/PIK3R1/HLA-DRB1/JAK2/SRSF7/NFKBIA/HLA-DQB1/PTPN11/POU2F1/PIK3CA/HLA-DQA1/ZC3HAV1/IFNGR1/NFKB1/BST2/HLA-DMA/BIRC2/NXF1/HCFC2/CGAS/AKT2/HLA-DRB5/FAS/HLA-G/EIF2B1/SRSF5/SRSF4/TRAF6/TRAF5/TNFRSF14/NECTIN2/PPP1CB/CCL5/IFNGR2/EIF2B3/PILRB/PIK3R3/SRSF6/HLA-DQA2/HLA-DMB/MAVS/OAS2/HLA-E/IKBKB/SRC/CARD9/MTOR/PIK3CB/RNASEL/CASP9/HLA-DOA/ITGA5/POU2F3/C5/TNF/IFNG/TLR3/SYK	2.78190844981042
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	52/2531	139/9376	1.38584288633889	FOS/GREB1/FKBP5/AKT3/HSPA1B/PGR/ESR1/JUN/HSPA1A/BCL2/CREB5/GNAI1/ADCY3/HSPA6/PIK3R1/GNAQ/NCOA1/EGFR/CREB3L2/ADCY9/NCOA2/ATF4/PIK3CA/ITPR1/ADCY1/RARA/ATF2/SOS2/ADCY2/AKT2/GABBR1/GNAO1/RAF1/MAPK1/PIK3R3/ADCY4/SP1/HSP90AA1/ADCY7/SRC/SOS1/PIK3CB/HBEGF/POMC/CREB3L4/HSPA1L/KRT23/ADCY5/PRKCD/ESR2/HSP90AB1/KRT34	2.7867461549156
Human Diseases	Immune disease	hsa05310	Asthma	16/2531	32/9376	1.85223231924141	PRG2/HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/FCER1G/HLA-DQA1/HLA-DMA/HLA-DRB5/CD40/HLA-DQA2/HLA-DMB/IL10/HLA-DOA/TNF	2.93637527645588
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	37/2531	93/9376	1.47381926477273	EGR1/MAPK10/JUN/CAMK2D/ADCY3/MAP2K3/MAP3K4/GNAQ/CACNA1C/EGFR/ADCY9/ATF4/ITPR1/ADCY1/SOS2/ADCY2/MAP2K4/MAP3K3/MAPK8/MAPK14/RAF1/MAPK1/ADCY4/CAMK2G/ADCY7/SRC/SOS1/CGA/CACNA1D/PLD2/PTK2B/HBEGF/MAP3K1/PLA2G4A/MAPK11/ADCY5/PRKCD	2.792254490838
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	37/2531	93/9376	1.47381926477273	COL4A1/LAMA2/COL4A2/AKT3/GADD45B/MYC/ITGA6/BCL2/LAMB1/COL4A4/GADD45G/GADD45A/LAMA3/PIK3R1/NFKBIA/PTEN/COL4A3/PIK3CA/LAMA4/NFKB1/POLK/BIRC2/RXRA/LAMC1/AKT2/LAMC3/TRAF6/TRAF5/TRAF1/PIK3R3/FHIT/IKBKB/CDKN1B/PIK3CB/CASP9/RARB/CDK2	2.792254490838
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	32/2531	78/9376	1.51978036450577	VCL/SEPTIN11/ARHGAP10/ELMO1/PIK3R1/SEPTIN6/WASF2/WASL/ARHGEF26/CAV1/PIK3CA/DOCK1/SEPTIN1/CTNNA3/SEPTIN8/CD2AP/CLTB/GAB1/CTNNB1/CBL/CLTCL1/CTNNA1/HCLS1/PIK3R3/DNM3/WASF1/SRC/PIK3CB/CTNNA2/CDH1/ITGA5/MET	2.80296312477207
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	79/2531	227/9376	1.28921897110195	AKAP13/AKT3/NFATC2/MYC/NFATC1/IL6R/ROCK2/CREB5/STAT3/GNAI1/ADCY3/CCL4/PIK3R1/GNAQ/PTGER3/EGFR/NFKBIA/CCL4L2/CREB3L2/CCL3/PPP3CB/ROCK1/ADCY9/GNG4/CXCL12/ATF4/PIK3CA/ARHGEF12/GNA13/ITPR1/RIPK1/CCL3L1/PDGFRA/NFKB1/ADCY1/CXCR4/ATF2/SOS2/IL1R1/ADCY2/CGAS/AKT2/FAS/RPS6KB1/GNB4/HLA-G/GNB5/MAPK14/GNAO1/RAF1/CTNNB1/PTGER2/TRAF5/MAPK1/CCL5/GNA12/PPP3CA/PIK3R3/ADCY4/SP1/GNG7/PRKCG/HLA-E/NFATC3/IKBKB/ADCY7/SRC/SOS1/MTOR/PIK3CB/PTK2B/PTGER4/CX3CL1/CASP9/CREB3L4/IL10RA/MAPK11/ADCY5/TNF	2.68224149031317
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	72/2531	205/9376	1.30108026327201	AKT3/GADD45B/HLA-DRA/MAPK10/PLCG2/MYC/JUN/HES1/BCL2/GADD45G/STAT3/HLA-DPA1/GADD45A/CCND2/HLA-DPB1/PIK3R1/HLA-DRB1/MAP2K3/CD44/NFKBIA/HLA-DQB1/PIK3CA/VIM/HLA-DQA1/RIPK1/NCOR2/MAP3K14/NFKB1/HLA-DMA/POLK/SNW1/TNFAIP3/SIN3A/CIR1/AKT2/HLA-DRB5/FAS/MAP2K4/HLA-G/NFKBIE/MAPK8/MAPK14/RELB/TRAF6/TRAF5/CD40/RBPJ/ENTPD1/PIK3R3/HLA-DQA2/HLA-DMB/MAVS/OAS2/HLA-E/IKBKB/CDKN1B/CCND3/ENTPD3/PIK3CB/RUNX3/CD247/CASP9/HLA-DOA/CD3E/CD3D/MAPK11/CDK2/TNF/JAK3/ITGAL/CCNA1/SYK	2.65030499738858
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	53/2531	144/9376	1.3634487905527	AKT3/KLF4/MYC/FGFR1/SMAD3/STAT3/ID4/IGF1/IGF1R/PIK3R1/JAK2/WNT9A/KAT6A/LIFR/ZFHX3/PIK3CA/LEFTY2/WNT2/AKT2/TBX3/ACVR2A/MAPK14/RAF1/CTNNB1/INHBB/PCGF5/MAPK1/WNT5B/AXIN1/APC/BMI1/BMPR2/RIF1/WNT2B/SMAD1/PIK3R3/BMPR1A/FZD8/PIK3CB/FZD4/IL6ST/TCF7/BMP4/BMPR1B/MAPK11/AXIN2/FZD3/ACVR2B/DLX5/WNT11/JAK3/WNT6/WNT5A	2.67252367200089
Human Diseases	Cancer: specific types	hsa05218	Melanoma	30/2531	73/9376	1.52238272814362	MITF/AKT3/GADD45B/PDGFRB/FGFR1/PDGFD/GADD45G/GADD45A/IGF1/IGF1R/PIK3R1/BRAF/EGFR/PTEN/PIK3CA/PDGFRA/POLK/AKT2/HGF/RAF1/MAPK1/FGF7/PIK3R3/PDGFB/PIK3CB/FGF1/PDGFC/CDH1/FGF10/MET	2.72448055912932
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	21/2531	47/9376	1.65518632783275	IRS2/INSR/SOCS3/MAPK10/SOCS2/PIK3R1/CACNA1C/PRKCE/PIK3CA/IRS1/MAPK8/MAPK1/PIK3R3/IKBKB/CACNA1D/MTOR/PIK3CB/PRKCZ/SOCS1/PRKCD/TNF	2.73804885597104
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	39/2531	101/9376	1.43043684060227	MITF/TCF7L2/CAMK2D/GNAI1/EDNRB/ADCY3/TCF7L1/WNT9A/GNAQ/CREB3L2/ADCY9/CREBBP/ASIP/WNT2/ADCY1/ADCY2/GNAO1/RAF1/CTNNB1/MAPK1/WNT5B/WNT2B/ADCY4/PRKCG/CAMK2G/ADCY7/EDN1/FZD8/KITLG/FZD4/TCF7/POMC/CREB3L4/ADCY5/LEF1/FZD3/WNT11/WNT6/WNT5A	2.64458875722101
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	78/2531	226/9376	1.27853204337017	FOS/AKT3/MAPK10/JUN/NFATC1/FXYD1/ROCK2/CAMK2D/CREB5/PLCE1/GNAI1/F2R/ADCY3/GLI3/PIK3R1/PDE3A/GRIA1/PTGER3/CACNA1C/NPR1/BRAF/NFKBIA/CREB3L2/AFDN/PPP1R12A/ROCK1/ADCY9/RAP1B/RRAS2/PIK3CA/CREBBP/OXTR/VIPR2/EDNRA/NFKB1/ADCY1/ADCY2/AKT2/RAP1A/TIAM1/MAPK8/GABBR1/RAF1/PTGER2/MYL9/MAPK1/PPP1CB/VAV3/PLN/PIK3R3/ADCY4/PPARA/VAV2/CAMK2G/ADCY7/ATP2B4/TSHR/EDN1/NPY1R/RRAS/CGA/CACNA1D/PLD2/PIK3CB/PTCH1/OXT/RAPGEF4/RYR2/LHCGR/POMC/ATP1B2/PDE3B/CREB3L4/RAPGEF3/ADCY5/POPDC2/ATP2A3/VAV1	2.5772931669504
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	56/2531	155/9376	1.33838722422605	THBS1/HLA-DRA/STX18/TLR4/ATP6V0A1/HLA-DPA1/HLA-DPB1/HLA-DRB1/PLA2R1/THBS3/EEA1/HLA-DQB1/STX12/TUBA1A/C1R/DYNC2H1/DYNC1I2/HLA-DQA1/HLA-DMA/CTSS/HLA-DRB5/HLA-G/STX7/FCGR2A/DYNC1LI1/RAB5A/MRC1/TFRC/MSR1/COLEC11/ITGB2/HLA-DQA2/HLA-DMB/ATP6V1E2/CD36/HLA-E/OLR1/NCF1/THBS4/PIKFYVE/COLEC12/RAB7A/FCGR2B/COMP/HLA-DOA/ITGA5/CORO1A/TUBA3E/FCGR3A/CYBB/NOS1/NCF2/CLEC7A/ATP6V1C2/FCAR/ITGAM	2.58306765088301
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	27/2531	65/9376	1.53877761906209	PBX1/NR4A1/CREB5/ADCY3/GNAQ/CACNA1C/PDE8B/CREB3L2/ADCY9/PDE8A/ATF4/ITPR1/ADCY1/ATF2/ADCY2/CYP11A1/ADCY4/SP1/ADCY7/CACNA1D/HSD3B1/CACNA1H/POMC/KCNK3/CREB3L4/ADCY5/AGT	2.6504099073008
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	20/2531	45/9376	1.64642872821458	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DRB5/FAS/HLA-G/HLA-DQA2/HLA-DMB/HLA-E/GZMB/HLA-DOA/TNF/IFNG/CD80/CD86/PRF1	2.64306470702211
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	23/2531	54/9376	1.57782753120564	HLA-DRA/HLA-DPA1/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DQA1/HLA-DMA/HLA-DRB5/FAS/HLA-G/CD40/HLA-DQA2/HLA-DMB/HLA-E/TSHR/CGA/GZMB/IL10/HLA-DOA/CD80/TG/CD86/PRF1	2.58931892521273
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	26/2531	63/9376	1.52882667619926	TCF7L2/GADD45B/GADD45G/GADD45A/TCF7L1/GLI3/WNT9A/WNT2/POLK/CTNNB1/WNT5B/AXIN1/APC/WNT2B/PTCH2/FZD8/PTCH1/FZD4/TCF7/BMP4/LEF1/AXIN2/FZD3/WNT11/WNT6/WNT5A	2.56084806422218
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	60/2531	170/9376	1.30745810769982	MAP3K5/MAPK10/JUN/MYH11/ROCK2/PRKAG2/TJP1/AMOTL2/CLDN5/PRKCE/ACTN4/JAM3/MPDZ/AFDN/TJP2/MYH10/AMOTL1/ROCK1/TUBA1A/YBX3/RAB8B/PARD3/JAM2/PRKAB2/ARHGAP17/DLG2/PPP2CB/RAPGEF2/MAGI1/PPP2CA/PRKAA1/RAP1A/PPP2R2A/TIAM1/MAPK8/PPP2R2D/PPP2R1B/DLG1/MYL9/CGNL1/HCLS1/CLDN4/RAP2C/ERBB2/SRC/CACNA1D/AMOT/PRKCZ/TJAP1/ARHGEF18/MAP3K1/CLDN10/CLDN7/TUBA3E/PATJ/MPP4/IGSF5/LLGL2/WAS/PPP2R2B	2.45991391893251
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	17/2531	37/9376	1.702051320384	TCF7L2/GADD45B/MYC/GADD45G/GADD45A/NTRK1/TCF7L1/PPARG/BRAF/POLK/RXRA/CCDC6/CTNNB1/MAPK1/TCF7/CDH1/LEF1	2.60174374642479
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	55/2531	154/9376	1.32302308517243	CACNB2/AKT3/CAMK2D/BCL2/CREB5/GNAI1/SLC8A1/ADCY3/GNAQ/CACNA1C/SCN7A/CREB3L2/ADCY9/ATF4/PPP2CB/TPM1/ADCY1/PPP2CA/ATF2/ADCY2/PPP2R3A/AKT2/PPP2R2A/PPP2R2D/MAPK14/PPP2R1B/RPS6KA5/MYL3/MAPK1/PPP1CB/PPP2R5D/PLN/PPP2R5A/ADCY4/CAMK2G/ADCY7/ATP2B4/PIK3R5/ADRA1B/CACNA1D/RAPGEF4/RYR2/ATP1B2/CACNB1/PPP2R3B/CREB3L4/KCNE1/RAPGEF3/MAPK11/ADCY5/AGT/POPDC2/ATP2A3/KCNQ1/PPP2R2B	2.45768572379102
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	37/2531	97/9376	1.41304321261716	FOS/CAMK2D/PER1/GUCY1A2/GNAI1/PER2/ADCY3/GNAQ/GRIA1/CACNA1C/ADCY9/GNG4/GUCY1B1/ITPR1/ADCY1/RASD1/ADCY2/PER3/GNB4/GNB5/GUCY1A1/GNAO1/RPS6KA5/MAPK1/ADCY4/NOS1AP/GNG7/PRKCG/CAMK2G/ADCY7/RYR3/CACNA1D/CACNA1H/RYR2/ADCY5/NOS1/RYR1	2.48642723556368
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	56/2531	158/9376	1.31297480857619	INSR/AKT3/RPS6KA2/SGK1/CAB39L/RNF152/IGF1/IGF1R/PIK3R1/CLIP1/WNT9A/BRAF/DEPTOR/PTEN/PIK3CA/LPIN2/LRP6/WNT2/PRKAA1/SOS2/AKT2/RPS6KB1/IRS1/ULK2/SEH1L/RAF1/MAPK1/RPTOR/WNT5B/RICTOR/WDR59/GRB10/LRP5/CAB39/WNT2B/LPIN1/PIK3R3/ULK1/ATP6V1E2/PRR5/PRKCG/IKBKB/SOS1/MIOS/MTOR/FZD8/PIK3CB/FZD4/CASTOR2/PRR5L/TNF/FZD3/ATP6V1C2/WNT11/WNT6/WNT5A	2.41248464933478
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	37/2531	98/9376	1.39862440432514	NR4A1/CAMK2D/CREB5/PRKD1/ADCY3/GNAQ/CACNA1C/NPR1/PRKCE/CREB3L2/ADCY9/CAMK1/ATF4/ITPR1/NR4A2/ADCY1/ATF2/ADCY2/CYP11A1/DAGLB/ADCY4/CAMK1G/PRKCG/CAMK2G/ADCY7/ATP2B4/CACNA1D/HSD3B1/CACNA1H/PDE2A/POMC/ATP1B2/KCNK3/CREB3L4/ADCY5/DAGLA/AGT	2.41209673922359
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	48/2531	133/9376	1.33694964396372	FOS/AKT3/MAOB/MAPK10/CAMK2D/CREB5/GNAI1/GNAQ/GRIA1/CACNA1C/CREB3L2/PPP3CB/MAOA/GNG4/ATF4/ITPR1/PPP2CB/PPP2CA/ATF2/PPP2R3A/AKT2/PPP2R2A/GNB4/MAPK8/GNB5/PPP2R2D/MAPK14/GNAL/GNAO1/PPP2R1B/PPP1CB/PPP3CA/CLOCK/PPP2R5D/PPP2R5A/GNG7/PRKCG/CAMK2G/ARRB2/LRTOMT/CACNA1D/PPP2R3B/CREB3L4/MAPK11/ADCY5/KIF5C/SLC18A2/PPP2R2B	2.37973901254135
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	30/2531	77/9376	1.4432979110972	AKT3/GADD45B/MAPK10/GADD45G/SMAD3/STAT3/GADD45A/PIK3R1/TGFBR1/BRAF/EGFR/TGFBR2/ARHGEF6/PIK3CA/NFKB1/POLK/TGFB2/AKT2/RPS6KB1/MAPK8/RAF1/MAPK1/PIK3R3/ERBB2/IKBKB/PLD2/MTOR/PIK3CB/TGFB3/CASP9	2.37502348322399
NA	NA	hsa04081	Hormone signaling	74/2531	219/9376	1.25173690980698	IRS2/INSR/PRLR/ADRA2C/ESR1/RAMP1/STAT3/GNAI1/ADCY3/CSH1/IGF1/IGF1R/PIK3R1/GNA14/JAK2/GNAQ/STAT5B/SLC40A1/NPR1/GHR/STAT5A/RAMP2/ADCY9/GNG4/AVPR1A/PIK3CA/GNA13/PTH1R/OXTR/VIPR2/HEPH/ADCY1/DIO2/ADCY2/CSH2/IRS1/GNB4/GNB5/RAMP3/GNAO1/SLC16A10/GNA12/ADRA2A/SMAD1/PIK3R3/ADCY4/IGF2/GNG7/BMPR1A/ADCY7/TSHR/SRC/THRB/CGA/ADRA1B/PIK3CB/SLC16A2/OXT/RAPGEF4/NPR3/LEPR/LHCGR/POMC/NPR2/BMPR1B/RAPGEF3/ADCY5/THPO/ESR2/AGT/GNA15/MCHR1/NOS1/DIO1	2.29211989949558
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	68/2531	200/9376	1.25951797708416	FOS/LPAR1/MAPK10/JUN/MYH11/ROCK2/TLR4/WIPF1/F2R/MYO1E/PAK3/MYO6/CYTH3/TJP1/CLDN5/NFKBIA/WASF2/MYH10/WASL/ROCK1/TUBA1A/PTPN11/CYTH1/WIPF3/ARHGEF12/GNA13/MYO1D/RIPK1/NFKB1/ABI1/TNFSF10/IL1R1/FAS/FCGR2A/MAPK8/MAPK14/MYO10/TRAF6/SEC24B/PAK2/MAPK1/GNA12/HCLS1/NCKAP1/CLDN4/CASP7/NAIP/IKBKB/CYFIP2/WASF1/SRC/FYN/NCK2/NLRP3/MYO5C/MYO1F/CASP9/CLDN10/MAPK11/NCKAP1L/TNF/PTPN6/IL18/LPAR2/CLDN7/TUBA3E/BAIAP2L1/CYTH4	2.25580070054972
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	30/2531	78/9376	1.42479409172416	FOS/MAPK10/SERPING1/JUN/C1QA/C1QB/TLR4/GNAI1/IRF1/NOD1/C1R/C1QC/C2/NFKB1/MAPK8/MAPK14/CFL2/TRAF6/MAPK1/CASP7/ITGB2/NLRP3/IL10/IRF8/ITGA5/C5/MAPK11/TNF/IL23A/ITGAM	2.29074096682358
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	82/2531	248/9376	1.22486330788545	FOS/TCF7L2/AKT3/RHOB/MAPK10/MYC/JUN/ROCK2/BCL2/TLR4/AHNAK/TCF7L1/ELMO1/DYNC2LI1/PAK3/MAP2K3/NOD1/MYO6/CYTH3/NFKBIA/WASL/RIPK2/TUBA1A/EXOC4/ARHGEF26/RHOJ/CYTH1/DYNC2H1/FYCO1/PIK3CA/DYNC1I2/SNX9/RIPK1/NFKB1/ABI1/BIRC2/TNFSF10/KLC1/AKT2/PLEKHM2/MAP2K4/GCC2/ACTR1B/KPNA1/MAPK8/MAPK14/DYNC1LI1/RAB5A/RAF1/CTNNB1/TRAF6/KPNA4/MYL9/ARL8B/MAPK1/PTPRC/PODXL/NCKAP1/CASP7/EXOC2/NAIP/HSP90AA1/IKBKB/CYFIP2/RRAS/PIK3CB/RAB7A/RHOH/NLRP3/TCF7/PIK3C2B/DYNLRB2/MAPK11/PIK3C2G/NCKAP1L/TNF/LEF1/IL18/TUBA3E/KIF5C/HSP90AB1/CYTH4	2.18223543921808
Human Diseases	Cancer: specific types	hsa05214	Glioma	29/2531	76/9376	1.41354571731581	AKT3/GADD45B/PLCG2/PDGFRB/CAMK2D/GADD45G/GADD45A/IGF1/IGF1R/PIK3R1/BRAF/EGFR/PTEN/CAMK1/PIK3CA/PDGFRA/POLK/SOS2/AKT2/RAF1/MAPK1/PIK3R3/CAMK1G/PRKCG/CAMK2G/SOS1/PDGFB/MTOR/PIK3CB	2.2010698961906
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	83/2531	253/9376	1.2152986758659	FOXO1/VCL/AKT3/TLN2/SEPTIN11/MAPK10/PLCG2/FNBP1/JUN/ROCK2/BCL2/TLR4/PLCE1/ELMO1/PIK3R1/CALCOCO2/NOD1/CD44/CYTH3/SEPTIN6/EGFR/PRKCE/ACTN4/NFKBIA/WASF2/WASL/ROCK1/RIPK2/FBXW11/CYTH1/PIK3CA/ITPR1/DIAPH1/RIPK1/FNBP1L/MAP1LC3A/NFKB1/DOCK1/MALT1/CAST/IL1R1/CGAS/SEPTIN8/AKT2/RPS6KB1/ATG5/FOXO3/MAPK8/MAPK14/TRAF6/TRAF5/MAP1LC3B/MYL9/RPS6KA5/UBE2D1/MAPK1/BTRC/RPTOR/CCL5/HCLS1/PLCD3/PIK3R3/NAIP/IKBKB/WASF1/SRC/U2AF1L4/UBE2D3/MTOR/PIK3CB/NLRP3/MAP1LC3C/PLCD1/ATG16L1/FOXO4/ITGA5/TECPR1/MAPK11/PRKCD/TNF/IL18/PRKCQ/CYTH4	2.11094912412637
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	33/2531	89/9376	1.3735655401116	LPAR1/PDGFRB/GUCY1A2/PDGFD/GNAI1/ADCY3/GNAQ/TJP1/EGFR/ADCY9/TUBA1A/GUCY1B1/ITPR1/PDGFRA/ADCY1/SOS2/ADCY2/HTR2B/GUCY1A1/RAF1/HTR2A/MAPK1/MAP2K5/ADCY4/PRKCG/ADCY7/SRC/SOS1/PDGFB/PDGFC/GRM5/ADCY5/TUBA3E	2.15312415235481
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	41/2531	115/9376	1.32072217545909	FOS/AKT3/CAMK2D/BCL2/CREB5/GNAI1/ADCY3/PIK3R1/JAK2/GNAQ/CACNA1C/KCNQ3/CREB3L2/ADCY9/GNG4/ATF4/PIK3CA/ITPR1/ADCY1/ADCY2/AKT2/GNB4/GNB5/GNAO1/MAPK1/PIK3R3/ADCY4/GNG7/PRKCG/CAMK2G/ADCY7/PIK3R5/FYN/CACNA1D/PIK3CB/CHRM5/CREB3L4/ADCY5/CHRM3/KCNQ1/KCNJ2	2.10423360310492
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	27/2531	71/9376	1.40874007378924	MAPK10/PLCG2/JUN/ATP6V0A1/NOD1/TJP1/EGFR/JAM3/NFKBIA/PTPN11/JAM2/ADAM17/MAP3K14/CXCL2/NFKB1/MAP2K4/MAPK8/MAPK14/CCL5/ATP6V1E2/IKBKB/SRC/HBEGF/MAPK11/MET/ATP6V1C2/IGSF5	2.10214751719878
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	37/2531	103/9376	1.33073001576567	SMG1/UPF2/CPSF6/EIF4A3/PABPC4/ETF1/PPP2CB/FUS/TARDBP/RNGTT/PCF11/NXF1/PPP2CA/FIP1L1/PPP2R3A/PPP2R2A/PPP2R2D/DDX19A/ACIN1/PPP2R1B/CASC3/UPF1/GSPT1/WDR33/PPP1CB/CPSF7/SMG6/PPP2R5D/PPP2R5A/CSTF3/PAPOLG/NCBP1/PABPC1/PABPC5/PPP2R3B/MSI1/PPP2R2B	2.05223494581864
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	37/2531	103/9376	1.33073001576567	COL6A3/COL4A1/COL4A2/COL18A1/COL12A1/COL5A3/COL14A1/COL15A1/ELN/COL4A4/SLC8A1/SLC7A8/COL16A1/COL27A1/COL4A3/COL5A1/SLC38A2/COL21A1/XPNPEP2/SLC16A10/MME/COL11A1/SLC36A1/ACE2/COL24A1/CPB1/ATP1B2/COL17A1/COL6A2/COL26A1/COL25A1/COL23A1/COL28A1/SLC1A1/KCNQ1/COL19A1/KCNE3	2.05223494581864
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	41/2531	116/9376	1.30933663946375	GLUL/GNAI1/ADCY3/GNAQ/GRIA1/CACNA1C/HOMER1/PPP3CB/GLS/DLGAP1/ADCY9/GNG4/SLC38A2/ITPR1/ADCY1/GRM7/ADCY2/GNB4/GNB5/GNAO1/TRPC1/SHANK2/MAPK1/SLC1A2/PPP3CA/ADCY4/GNG7/PRKCG/ADCY7/GRK2/CACNA1D/PLD2/SLC1A3/GRM5/PLA2G4A/GRIK2/ADCY5/SHANK3/GRK3/SLC1A1/GRM8	2.03844899387607
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	30/2531	82/9376	1.35529194090835	HLA-DRA/HSPA1B/HSPA2/HSPA1A/CD74/HLA-DPA1/HLA-DPB1/HSPA6/HLA-DRB1/HLA-DQB1/HLA-DQA1/HLA-DMA/NFYB/CTSS/IFI30/HLA-DRB5/HLA-G/PSME1/HLA-DQA2/HSP90AA1/HLA-DMB/HLA-E/NFYC/CIITA/CD4/HLA-DOA/HSPA1L/TNF/IFNG/HSP90AB1	1.96487955235198
Organismal Systems	Nervous system	hsa04730	Long-term depression	23/2531	60/9376	1.42004477808508	GUCY1A2/GNAI1/IGF1/IGF1R/GNAQ/GRIA1/BRAF/GNA13/GUCY1B1/ITPR1/PPP2CB/PPP2CA/GUCY1A1/GNAO1/PPP2R1B/RAF1/MAPK1/GNA12/PRKCG/PLA2G4A/GRID2/NOS1/RYR1	1.98473011670952
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	49/2531	144/9376	1.26054699503929	FOXO1/TCF7L2/MAP3K5/AKT3/MAPK10/C1QA/C1QB/TLR4/NOX4/PRKAG2/TCF7L1/TRA2B/MAP2K3/ACACB/NFKBIA/ALDH7A1/TRA2A/CAMKK2/C5AR1/PRKAB2/ADH1B/SIRT1/C1QC/LPIN2/C2/RIPK1/MAP3K14/CXCL2/NFKB1/PRKAA1/AKT2/FAS/MAP2K4/FOXO3/MAPK8/MAPK14/CTNNB1/TRAF6/LPIN1/IL17RC/PPARA/IKBKB/TCF7/PPARGC1A/C5/MAPK11/ADH1C/TNF/LEF1	1.91586278455433
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	37/2531	105/9376	1.30538277737013	GADD45B/PLCG2/CCL21/CFLAR/BCL2/TLR4/GADD45G/GADD45A/CCL4/PLAU/NFKBIA/CCL4L2/CXCL12/RIPK1/MAP3K14/CXCL2/NFKB1/MALT1/TNFAIP3/BIRC2/IL1R1/CCL13/VCAM1/RELB/TRAF6/TRAF5/CD40/TRAF1/PPP1R13L/IKBKB/TNF/LCK/EDA/EDARADD/PRKCQ/SYK/BCL2A1	1.91346659202533
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	44/2531	128/9376	1.27340971947847	PDE1A/ENPP1/GUCY1A2/ADCY3/PRPS2/PDE3A/PDE8B/NPR1/ADA/ADCY9/PDE8A/NT5C2/GUCY1B1/PDE5A/ADK/ADCY1/ADA2/IMPDH2/ADCY2/GART/AMPD3/PAPSS2/GUCY1A1/ENTPD1/PDE7A/ENTPD6/ADCY4/FHIT/ADCY7/RRM1/ENTPD3/HDDC3/ENTPD5/PDE2A/NPR2/PDE9A/PDE3B/ADCY5/NT5M/AK8/GDA/PDE11A/AK9/PDE1C	1.89382571009956
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	17/2531	42/9376	1.49942616319542	MAOB/AOC1/AOX1/DLST/ALDH7A1/MAOA/INMT/HADH/DHTKD1/KYAT1/KMO/AFMID/IDO2/AADAT/HAAO/EHHADH/IDO1	1.97245462459684
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	45/2531	133/9376	1.25339029121599	NFATC2/PLCG2/NFATC1/PIK3R1/BRAF/PPP3CB/TYROBP/PTPN11/PIK3CA/FCER1G/IFNGR1/TNFSF10/SOS2/FAS/LCP2/HLA-G/RAF1/MAPK1/VAV3/IFNGR2/PPP3CA/ICAM2/ITGB2/PIK3R3/VAV2/PRKCG/HLA-E/FYN/SOS1/PIK3CB/PTK2B/GZMB/CD247/LAT2/TNF/PTPN6/LCK/CD48/IFNG/FCGR3A/ITGAL/KLRK1/VAV1/PRF1/SYK	1.78959311044954
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	36/2531	104/9376	1.28231468255174	PLPP3/GPCPD1/PEMT/PLA2G2A/PNPLA7/ETNK1/LPCAT1/PISD/SGMS2/AGPAT4/GDPD5/PLA2G6/LPIN2/PLA2G5/LPGAT1/CHKA/DGKH/CHPT1/LCAT/CEPT1/LPIN1/CDS2/DGKA/PLA1A/PGS1/PLPP1/GPD2/PLD2/MBOAT1/GPD1L/LCLAT1/SGMS1/ETNK2/DGKB/PLA2G4A/PLB1	1.76038803516087
Human Diseases	Substance dependence	hsa05032	Morphine addiction	32/2531	91/9376	1.30266888386209	PDE1A/GNAI1/ADCY3/PDE3A/PDE8B/GRK5/ADCY9/PDE8A/GNG4/ADCY1/ADCY2/GNB4/GNB5/GABBR1/GNAO1/GRK4/PDE7A/ADCY4/GNG7/PRKCG/ADCY7/GRK2/GABRB3/ARRB2/PDE2A/GABRR2/PDE3B/ADCY5/GRK3/PDE11A/GABRG3/PDE1C	1.76417840599396
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	27/2531	75/9376	1.33360726985381	THBS1/GADD45B/BCL2/GADD45G/GADD45A/SERPINE1/SESN3/IGFBP3/CCND2/IGF1/SESN1/ZNF385A/MDM4/PTEN/CHEK2/RPRM/SIAH1/COP1/FAS/PPM1D/PPP1R13L/ATR/BBC3/CCND3/PMAIP1/CASP9/CDK2	1.76378766120091
Organismal Systems	Endocrine system	hsa04924	Renin secretion	25/2531	69/9376	1.34219733278363	PDE1A/GUCY1A2/GNAI1/PDE3A/GNAQ/CACNA1C/NPR1/PPP3CB/ACE/GUCY1B1/ITPR1/EDNRA/GUCY1A1/PTGER2/PPP3CA/REN/AQP1/EDN1/CACNA1D/PTGER4/PDE3B/ADCY5/AGT/KCNJ2/PDE1C	1.73476756332975
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	47/2531	142/9376	1.22612561977952	CBLB/SOCS3/HERC1/MID1/HERC3/PRKN/KLHL13/FBXW11/UBE2H/UBE2G2/FANCL/UBE2Q2/ITCH/RHOBTB1/FBXW7/BIRC2/SMURF2/UBE2G1/SIAH1/COP1/UBE2R2/UBR5/SMURF1/PIAS1/MGRN1/UBA2/UBE2W/UBE2E1/CUL3/ANAPC7/CBL/TRAF6/WWP2/UBE2D1/BTRC/UBE2E2/ANAPC4/KLHL9/TRIP12/UBE2D3/FBXO4/PPIL2/SOCS1/MAP3K1/UBA7/HERC4/CDC23	1.65098828580136
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	22/2531	60/9376	1.35830370077703	AKT3/NFATC2/PLCG2/HSPB1/PIK3R1/PPP3CB/MAPKAPK2/PIK3CA/SH2D2A/AKT2/MAPK14/RAF1/MAPK1/PPP3CA/PIK3R3/PRKCG/SRC/PIK3CB/KDR/PLA2G4A/CASP9/MAPK11	1.69300080125413
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	34/2531	99/9376	1.27224038089309	CFD/HLA-DRA/CFH/C1QA/C1QB/HLA-DPA1/MASP1/HLA-DPB1/HLA-DRB1/HLA-DQB1/C1R/C5AR1/C1QC/HLA-DQA1/C2/HLA-DMA/HLA-DRB5/FCGR2A/ITGB2/HLA-DQA2/HLA-DMB/FPR3/FCGR2B/IL10/HLA-DOA/KRT23/C5/SELP/DEFB1/FCGR3A/ITGAL/FCAR/KRT34/ITGAM	1.65581322603009
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	26/2531	73/9376	1.31939836439114	SAMHD1/ELL2/NUP153/ELL/CPSF6/MAP1B/KAT2B/CREBBP/MLLT1/PSIP1/CHMP4B/BST2/MX2/CXCR4/BICD2/SERINC5/MDFIC/CCNT1/PDCD6IP/CPSF7/KAT2A/AFF4/CD4/APOBEC3G/CHMP6/APOBEC3D	1.66581815883107
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	29/2531	83/9376	1.29433101826508	SFMBT2/OGT/RYBP/ASXL1/YAF2/CREBBP/EZH1/SCMH1/MGA/FOXK2/AUTS2/CBX7/PHC3/SFMBT1/PCGF5/FBRSL1/PHC1/UBE2D1/LCOR/BMI1/FOXK1/BCORL1/EZH2/UBE2D3/MBD5/ASXL3/L3MBTL1/SCML2/L3MBTL4	1.63772921017167
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	37/2531	110/9376	1.24604719658058	AKT3/MAPK10/PGR/RPS6KA2/GNAI1/ADCY3/IGF1/IGF1R/PIK3R1/BRAF/ADCY9/CPEB4/PIK3CA/ADCY1/CPEB3/ADCY2/AKT2/CPEB2/MAPK8/MAPK14/RAF1/ANAPC7/MAPK1/ANAPC4/PIK3R3/ADCY4/HSP90AA1/ADCY7/PIK3CB/SPDYE1/PDE3B/MAPK11/CDK2/ADCY5/CDC23/HSP90AB1/CCNA1	1.57838738165646
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	6/2531	12/9376	1.85223231924141	CD46/NPC1/NCAM2/FCGR2B/NGFR/NCAM1	1.79623396827468
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	62/2531	196/9376	1.17182044686701	FOS/ZFP36/TCF7L2/AKT3/MAPK10/NFATC2/PLCG2/MYC/JUN/NFATC1/CLEC2B/STAT3/TCF7L1/PIK3R1/JAK2/RCAN1/NFKBIA/PPP3CB/MAPKAPK2/GNG4/PIK3CA/CREBBP/ITPR1/IFNGR1/MAP1LC3A/CXCL2/NFKB1/ANGPT2/AKT2/FAS/MAP2K4/GNB4/HLA-G/MAPK8/GNB5/MAPK14/RAF1/CTNNB1/MAP1LC3B/MAPK1/PPP3CA/PIK3R3/GNG7/HLA-E/NFATC3/IKBKB/PIK3R5/SRC/PDGFB/MTOR/PIK3CB/IL6ST/MAP1LC3C/TCF7/CASP9/MAPK11/LEF1/HCK/TLR3/CD86/PREX1/SYK	1.478177283611
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	19/2531	52/9376	1.35355438713795	INSR/BMP6/ADCY3/IGF1/IGF1R/ADCY9/ADCY1/ADCY2/CYP11A1/ADCY4/ADCY7/CGA/HSD3B1/HSD17B2/LHCGR/CYP19A1/ALOX5/PLA2G4A/ADCY5	1.55453947444343
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	19/2531	52/9376	1.35355438713795	OSBPL5/MYLIP/APOE/APOA2/SORT1/APOC3/LIPA/NPC1/LCAT/SOAT1/ABCA1/LPL/APOC1/APOB/CD36/APOC2/APOA1/LIPC/LRP2	1.55453947444343
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	68/2531	217/9376	1.16084606182872	FOS/AKT3/KLF4/PGR/ESR1/BCL6/MYC/AR/JUN/BCL2/CREB5/STAT3/RPS6KA2/GNAI1/ADCY3/JAG1/PIK3R1/JAK2/STAT5B/CACNA1C/EGFR/CREB3L2/STAT5A/ADCY9/ATF4/PIK3CA/GSTM5/NFKB1/ADCY1/GSTT2B/RXRA/ATF2/SOS2/ADCY2/AKT2/RPS6KB1/ARNT/KPNA1/KPNA6/RAF1/KPNA4/MAPK1/FGF7/GSTA4/KPNA5/PIK3R3/ADCY4/DLL1/PPARA/HSP90AA1/PRKCG/ADCY7/SRC/SOS1/CCND3/ARRB2/PAQR7/CACNA1D/MTOR/GSTM2/PIK3CB/FGF10/CREB3L4/ADCY5/ESR2/DLL4/GSTA1/HSP90AB1	1.45767684127076
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	36/2531	108/9376	1.23482154616094	NUP153/NUP98/AHCTF1/UPF2/EIF4A3/RANBP17/THOC2/IPO7/THOC1/NXF1/NMD3/SENP2/NUP214/KPNA1/KPNA6/DDX19A/ACIN1/SEH1L/CASC3/KPNA4/UPF1/RANGAP1/NUP54/THOC6/NUP85/KPNA5/XPO4/IPO11/NUP43/NUP50/NCBP1/NUP210L/NUP155/NUP35/NUP205/NUP210	1.49245688227076
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	26/2531	75/9376	1.28421440800738	GPX3/CREB5/ADCY3/GNAQ/CREB3L2/ALB/ADCY9/ATF4/ITPR1/ADCY1/TTF2/ATF2/ADCY2/ADCY4/PRKCG/ADCY7/TSHR/CGA/TTR/ATP1B2/CREB3L4/ADCY5/DUOX1/TG/SLC26A4/LRP2	1.50264670850428
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	67/2531	214/9376	1.15980902232873	FOS/AKT3/MAPK10/SAMHD1/NFATC2/PLCG2/JUN/NFATC1/WEE1/BCL2/TLR4/GNAI1/TNFRSF1B/PIK3R1/PAK3/MAP2K3/GNAQ/NFKBIA/PPP3CB/FBXW11/GNG4/PIK3CA/ITPR1/RIPK1/DCAF1/NFKB1/BST2/AP1M1/CXCR4/CGAS/AKT2/FAS/RPS6KB1/GNB4/HLA-G/MAPK8/GNB5/MAPK14/CFL2/GNAO1/AP1G1/RAF1/TRAF6/TRAF5/PAK2/MAPK1/BTRC/ATR/PPP3CA/PIK3R3/GNG7/PRKCG/HLA-E/NFATC3/IKBKB/MTOR/CD4/PIK3CB/PTK2B/APOBEC3G/CD247/CASP9/CD3E/CD3D/MAPK11/TNF/APOBEC3D	1.43799713939703
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	35/2531	105/9376	1.23482154616094	MITF/MAPK10/JUN/CITED2/GABARAPL1/EIF2AK3/CALCOCO2/USP15/PRKN/RABGEF1/ARIH1/RRAS2/ATF4/MRAS/MAP1LC3A/TBC1D15/TFE3/SMURF2/SIAH1/SMURF1/FOXO3/MAPK8/RAB5A/MAP1LC3B/AMFR/OPA1/CCZ1B/ULK1/SP1/SRC/RRAS/RAB7A/MTX3/MAP1LC3C/USP30	1.47134421769337
Cellular Processes	Cell motility	hsa04814	Motor proteins	61/2531	194/9376	1.16480589148171	ACTG2/ACTA2/MYH11/KIF13B/MYO1E/MYO9A/DYNC2LI1/MYO6/STARD9/KIF16B/MYO15B/KIFAP3/MYH10/MYO16/TUBA1A/KIF1B/MYO9B/DYNC2H1/DYNC1I2/MYO1D/TPM1/KIF13A/KLC1/KIF21A/ACTR1B/HOOK3/DYNC1LI1/MYO10/MYL9/MYL3/KIF9/DNAH11/TNNT3/KIF27/MYO3B/DNAH7/MYO18A/TUBE1/DNAH6/DYNLRB2/MYO5C/MYO1F/DNAH9/MYH13/DNAH17/DNAH1/MYH3/TNNI2/CENPE/MYO18B/KIF6/TUBA3E/MYO7B/DNAH3/DNAH12/MYO15A/KIFC2/KIF5C/DNAH2/DNAH10/TNNC2	1.41042480773335
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	20/2531	56/9376	1.32302308517243	HSPA1B/HSPA1A/TLR4/CLK1/HSPA6/NFKBIA/CXCL2/NFKB1/SAR1A/CASP7/ITGB2/NAIP/CLK4/HSPD1/CASP9/HSPA1L/TNF/IL18/CR1L/ITGAM	1.47422782047148
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	31/2531	94/9376	1.22168514673369	FOS/FOSB/MAPK10/JUN/JUND/NFKBIA/USP25/MAPK6/CXCL2/NFKB1/TNFAIP3/CSF3/FOSL1/S100A8/MAPK8/MAPK14/TRAF6/TRAF5/S100A9/MAPK1/IL17RC/HSP90AA1/IKBKB/IL17RE/IL17D/MAPK11/TNF/IL17B/IFNG/CEBPB/HSP90AB1	1.31348381275644
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	14/2531	38/9376	1.3648027615463	INSR/SGK1/IGF1/PIK3R1/PIK3CA/IRS1/MAPK1/PIK3R3/PRKCG/PIK3CB/ATP1B2/SCNN1B/HSD11B2/NR3C2	1.37014952763857
Human Diseases	Infectious disease: viral	hsa05162	Measles	43/2531	136/9376	1.17126455481442	FOS/AKT3/CBLB/MAPK10/HSPA1B/JUN/HSPA1A/BCL2/TLR4/STAT3/CCND2/HSPA6/PIK3R1/STAT5B/NFKBIA/STAT5A/PIK3CA/NFKB1/TNFAIP3/MX2/AKT2/FAS/CD46/MAPK8/TRAF6/PIK3R3/MAVS/OAS2/IKBKB/CDKN1B/BBC3/CCND3/PIK3CB/FCGR2B/IL2RB/IL2RA/CASP9/HSPA1L/CD3E/CD3D/IL2RG/CDK2/JAK3	1.22333652641861
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	22/2531	65/9376	1.25381880071726	AKT3/TRPC4/PIK3R1/GNAQ/CACNA1C/PIK3CA/ITPR1/AKT2/GABBR1/TRPC1/RAF1/MAPK1/PIK3R3/PRKCG/CGA/ARRB2/CACNA1D/PIK3CB/CACNA1H/KISS1/ESR2/HCN1	1.24861137560115
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	10/2531	26/9376	1.42479409172416	SLC19A2/BTD/CUBN/LMBRD1/TCN2/APOB/SLC19A1/SLC19A3/APOA1/PLB1	1.31887707946934
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	9/2531	23/9376	1.44957311940632	ENPEP/ACE/ANPEP/NLN/MME/LNPEP/REN/ACE2/AGT	1.31260414589704
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	29/2531	89/9376	1.2070727473708	PLCL1/GLUL/GNAI1/GABARAPL1/ADCY3/CACNA1C/GLS/ADCY9/GPHN/GNG4/SLC38A2/ADCY1/ADCY2/GNB4/GNB5/GABBR1/GNAO1/ADCY4/TRAK2/GNG7/PRKCG/ADCY7/SRC/GABRB3/CACNA1D/GABRR2/ADCY5/ABAT/GABRG3	1.19350766006239
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	23/2531	69/9376	1.23482154616094	FOS/FOSB/MAOB/JUN/CAMK2D/CREB5/GRIA1/CACNA1C/CREB3L2/ARC/PPP3CB/MAOA/ATF4/SIRT1/ATF2/PPP1CB/PPP3CA/PRKCG/CAMK2G/CACNA1D/CREB3L4/ADCY5/SLC18A2	1.19042658263064
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	28/2531	86/9376	1.20610476601766	CAMK2D/CREB5/ADCY3/GNAQ/CACNA1C/CREB3L2/ADCY9/ATF4/ADCY1/KCNMB1/ATF2/ADCY2/RIMS2/TRPM4/ADCY4/PRKCG/CAMK2G/ADCY7/CACNA1D/SLC2A1/RAPGEF4/KCNMB2/RYR2/ATP1B2/KCNMB3/CREB3L4/ADCY5/CHRM3	1.16754704176643
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	57/2531	187/9376	1.12916836574075	TXNIP/MAPK10/JUN/BCL2/TLR4/GABARAPL1/GBP2/NOD1/ANTXR2/GBP1/NFKBIA/ERBIN/RIPK2/MCU/ANTXR1/ITPR1/TANK/RIPK1/MAP1LC3A/CXCL2/NFKB1/PKN2/TNFAIP3/BIRC2/NLRP1/DNM1L/ATG5/NEK7/MAPK8/MAPK14/TRAF6/TRAF5/MAP1LC3B/MAPK1/CCL5/CARD16/NAIP/HSP90AA1/MAVS/OAS2/IKBKB/CARD8/P2RX7/CARD9/NLRP3/MAP1LC3C/GBP4/ATG16L1/RNASEL/MAPK11/CARD18/PRKCD/TNF/IL18/CYBB/GPSM3/HSP90AB1	1.08489529787974
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	48/2531	156/9376	1.13983527337933	AKT3/SOCS3/MYC/CFLAR/STAT3/PIK3R1/BRAF/CLDN5/EGFR/NFKBIA/PIK3CA/PPP2CB/RIPK1/NFKB1/MX2/RXRA/PPP2CA/SOS2/AKT2/FAS/PPP2R2A/PIAS1/PPP2R2D/NR1H3/PPP2R1B/RAF1/CTNNB1/TRAF6/MAPK1/CLDN4/PIK3R3/PPARA/MAVS/OAS2/IKBKB/SOS1/PIK3CB/YWHAZ/RNASEL/EIF3E/CASP9/CLDN10/CDK2/TNF/IFNG/CLDN7/TLR3/PPP2R2B	1.07092377199941
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	10/2531	27/9376	1.37202394017882	ACSM3/HADH/OXCT1/ACSM1/ACSM5/EHHADH/OXCT2/ABAT/L2HGDH/ALDH5A1	1.17710491980626
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/2531	21/9376	1.41122462418393	UST/XYLT1/CHST7/CHSY3/CHST11/DSEL/CHST3/CHSY1	1.1471279151498
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	34/2531	109/9376	1.15552107989372	FOS/AKT3/MAPK10/JUN/CTSK/TLR4/CCL4/PIK3R1/MAP2K3/NFKBIA/CCL4L2/CCL3/PIK3CA/RIPK1/CCL3L1/NFKB1/AKT2/MAP2K4/MAPK8/MAPK14/TRAF6/CD40/MAPK1/CCL5/MAP3K8/PIK3R3/IKBKB/PIK3CB/CXCL9/MAPK11/TNF/CD80/TLR3/CD86	0.993065547666144
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	14/2531	41/9376	1.26493914484779	THBS1/MYC/BRAF/EGFR/DAPK1/RASSF1/RAF1/RPS6KA5/MAPK1/ERBB2/DAPK2/SRC/HBEGF/CDH1	1.03377465873349
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	24/2531	75/9376	1.1854286843145	REV3L/MAP3K5/AKT3/BCL2/PIK3R1/PIK3CA/ERCC1/GSTM5/GSTT2B/BIRC2/AKT2/FAS/MLH1/MAPK1/GSTA4/PIK3R3/ERBB2/BBC3/PMAIP1/GSTM2/PIK3CB/CASP9/MSH2/GSTA1	0.980364803111009
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/2531	38/9376	1.26731685000728	ENPP1/AOX1/SIRT1/NT5C2/NNMT/NADK/NAPRT/NADK2/NNT/NMNAT3/NUDT12/NMNAT2/NT5M	1.00400571041406
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	15/2531	45/9376	1.23482154616094	ABCA8/ABCA9/ABCA6/ABCC9/ABCD2/ABCG1/ABCA1/ABCC5/ABCB1/ABCB7/ABCB10/ABCB5/ABCA3/DEFB1/ABCA10	0.960119057240156
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	33/2531	107/9376	1.14249843990591	FOXO1/AKT3/CAMK2D/CREB5/PRKAG2/GNAQ/ACACB/CREB3L2/PPP3CB/PRKAB2/ATF4/SIRT1/CREBBP/ITPR1/PRKAA1/ATF2/ADCY2/AKT2/PYGL/PHKB/PPP3CA/PPP4R3A/PYGM/PPARA/CAMK2G/SLC2A1/PHKA2/PDE3B/CREB3L4/PPARGC1A/PHKG1/LDHC/FBP1	0.901426958110659
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	19/2531	59/9376	1.19296318866396	ENPP1/UCK2/NT5C2/DPYD/CMPK1/CTPS1/ENTPD1/ENTPD6/CDADC1/CTPS2/RRM1/ENTPD3/CDA/ENTPD5/UPP2/NT5M/UPB1/AK9/DPYS	0.90408114041483
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	11/2531	32/9376	1.27340971947847	ACSS3/ACACB/HIBCH/ACSS1/PCCA/BCKDHB/ALDH6A1/SUCLG2/EHHADH/ABAT/LDHC	0.942036018223212
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	7/2531	19/9376	1.3648027615463	DLST/BCKDHB/AMT/DHTKD1/ACSM1/LIPT1/GLDC	0.967857873863491
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	21/2531	67/9376	1.1611008568379	CAMK2D/RPS6KA2/GNAQ/GRIA1/CACNA1C/BRAF/PPP3CB/RAP1B/ATF4/CREBBP/ITPR1/ADCY1/RAP1A/RAF1/MAPK1/PPP1CB/PPP3CA/PRKCG/CAMK2G/GRM5/RAPGEF3	0.804690216239674
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	51/2531	173/9376	1.09206761018858	AKT3/HLA-DRA/SOCS3/DNAJB1/TLR4/HLA-DPA1/HLA-DPB1/PIK3R1/HLA-DRB1/JAK2/CALCOCO2/NUP98/NFKBIA/HLA-DQB1/PIK3CA/CREBBP/HLA-DQA1/IFNGR1/NFKB1/HLA-DMA/MX2/NXF1/TNFSF10/AKT2/HLA-DRB5/FAS/KPNA1/KPNA6/RAF1/MAPK1/CCL5/IFNGR2/KPNA5/PIK3R3/HLA-DQA2/HLA-DMB/MAVS/OAS2/IKBKB/CIITA/CCND3/PIK3CB/NLRP3/RAB11A/RNASEL/CASP9/HLA-DOA/TNF/IL18/IFNG/TLR3	0.743207691165131
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	11/2531	33/9376	1.23482154616094	STX18/STX8/SNAP23/STX2/STX5/STX17/STX7/GOSR1/VTI1A/BNIP1/STX11	0.821668661668129
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	22/2531	71/9376	1.14786228234679	AKT3/PDGFRB/MYC/FGFR1/NTRK1/PIK3R1/EGFR/PTEN/GLS/PIK3CA/PDGFRA/AKT2/RAF1/MAPK1/PIK3R3/ERBB2/MTOR/PIK3CB/SLC2A1/MET/LDHC/NTRK3	0.760454747784083
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	24/2531	78/9376	1.13983527337933	BTG2/TOB2/PABPC4/MTREX/PAN3/XRN1/DDX6/DCP1A/CNOT4/TENT4B/CNOT1/PARN/DCP2/EXOSC10/ZCCHC7/CNOT6L/HSPD1/PAN2/DIS3L/BTG1/PABPC1/EXOSC2/PABPC5/ENO3	0.754074492978128
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/2531	20/9376	1.29656262346898	UAP1/UGDH/GMDS/UGP2/GNE/NPL/CYB5RL	0.807293193272705
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	16/2531	51/9376	1.16218498462206	PLPP3/PLA2G2A/LPCAT1/PLA2G6/PLA2G5/CHPT1/CEPT1/AGPS/PLPP1/PAFAH1B1/PLD2/PLA2G4A/GDPD3/PAFAH2/PLB1/GDPD1	0.706181435381865
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	6/2531	17/9376	1.30745810769982	GGT5/CSAD/FMO4/CDO1/FMO2/BAAT	0.771508422372629
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	6/2531	17/9376	1.30745810769982	GLUL/GLUD1/CA5B/CA8/CPS1/CA13	0.771508422372629
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/2531	17/9376	1.30745810769982	MYH11/MYH10/TFRC/DAG1/PCDH1/PCDH11Y	0.771508422372629
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	13/2531	41/9376	1.17458634878723	MAOB/AOC3/ALDH7A1/DMGDH/MAOA/AMT/SDS/PSPH/GATM/AGXT2/SARDH/ALAS2/GLDC	0.681224147683943
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	15/2531	48/9376	1.15764519952588	AOX1/ALDH7A1/AUH/HADH/HIBCH/PCCA/BCKDHB/ALDH6A1/OXCT1/MCCC2/ACADSB/AGXT2/EHHADH/OXCT2/ABAT	0.665812715686574
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	59/2531	205/9376	1.06616299351457	GSN/JUN/CREB5/STAT3/CCND2/EGR3/REL/PIK3R1/STAT5B/ACTN4/NFKBIA/CREB3L2/RASA2/HDAC4/MAPKAPK2/STAT5A/HDAC7/UBR4/DDX3X/KAT2B/ATF4/PIK3CA/CREBBP/NFKB1/SNW1/ATF2/SRF/HLA-G/RBL2/TRAF5/DLG1/RBPJ/MAPK1/TRAF1/HDAC5/GTF2H3/PIK3R3/GTF2A1/KAT2A/HLA-E/CDKN1B/SRC/HDAC11/CCND3/PMAIP1/PIK3CB/EGR2/YWHAZ/IL6ST/HDAC9/HDAC10/RBL1/POLB/CREB3L4/CDK2/JAK3/CCNA1/SCIN/SYK	0.582409854595547
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	8/2531	24/9376	1.23482154616094	XYLT1/NDST1/HS6ST1/EXT1/EXTL3/HS6ST2/HS3ST2/HS3ST1	0.700384134473029
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	10/2531	31/9376	1.19498859305897	AOC3/ALDH7A1/DPYD/HIBCH/CSAD/ALDH6A1/EHHADH/UPB1/ABAT/DPYS	0.661219091037555
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	12/2531	38/9376	1.16983093846826	ADA/CD40/PTPRC/UNG/CIITA/CD4/CD3E/CD3D/IL2RG/IL7R/LCK/JAK3	0.637861893189548
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/2531	21/9376	1.23482154616094	ENPP1/DPYD/PPCDC/CSAD/PANK2/UPB1/DPYS	0.655044311158197
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	15/2531	49/9376	1.13401978729066	FOSB/MAOB/JUN/CREB5/GNAI1/CREB3L2/MAOA/ATF4/NFKB1/ATF2/GPSM1/CREB3L4/ADCY5/RGS9/SLC18A2	0.571927475307122
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/2531	18/9376	1.23482154616094	MTR/LMBRD1/TCN2/MTRR/ZNF143/MMAA	0.606355972937598
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	12/2531	39/9376	1.13983527337933	MTR/ALDH7A1/DMGDH/ALDH1L2/AHCY/MTHFD2/BHMT2/GART/AMT/SARDH/FTCD/GLDC	0.532096429185764
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	10/2531	32/9376	1.15764519952588	GABARAPL1/PPP2CB/PPP2CA/ATG5/ULK2/ATG10/RPTOR/ATG4C/MTOR/ATG16L1	0.543168166576679
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/2531	32/9376	1.15764519952588	MAPK10/BCL2/BIRC2/MAPK8/CASP7/BBC3/PMAIP1/SEPTIN4/NGFR/CASP9	0.543168166576679
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	45/2531	158/9376	1.05506904260586	GADD45B/MYC/WEE1/GADD45G/SMAD3/GADD45A/CCND2/CDKN1C/PDS5B/CHEK2/STAG1/CREBBP/CDC14A/PPP2CB/PPP2CA/NDC80/NIPBL/TGFB2/STAG2/CCNH/PDS5A/PPP2R1B/RBL2/ANAPC7/WAPL/CDKN2C/ATR/ANAPC4/ATRX/PPP2R5D/PPP2R5A/ORC3/CDKN1B/CCND3/YWHAZ/E2F5/TGFB3/RBL1/MCM6/CDK2/MTBP/CDC7/CDC23/DDX11/CCNA1	0.424485346103729
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	11/2531	36/9376	1.13191975064753	GALNT15/GALNT13/B4GALT5/GALNT17/ST6GALNAC3/GALNT11/ST6GALNAC2/GCNT1/GALNT16/C1GALT1C1L/GALNTL6	0.482206009585255
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	11/2531	36/9376	1.13191975064753	PRIM2/RFC1/POLA1/RFC2/POLD3/POLE/RFC3/MCM6/RPA4/POLE2/DNA2	0.482206009585255
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	16/2531	54/9376	1.09761915214306	REV3L/HES1/FANCL/ERCC1/POLK/WDR48/REV1/MLH1/ATR/RAD51C/FANCC/POLI/RMI2/RPA4/FANCE/FAAP24	0.437443881533014
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/2531	15/9376	1.23482154616094	ST6GALNAC5/ST6GALNAC6/ST6GALNAC3/ST3GAL5/ST8SIA1	0.553436036907284
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	7/2531	22/9376	1.17869329406271	MAOB/AOC1/HNMT/ALDH7A1/ASPA/MAOA/FTCD	0.510229890376451
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	42/2531	149/9376	1.04421150883408	MT-ND4L/MAPK10/MT-ND3/CNR1/MGLL/GNAI1/ADCY3/MT-ND2/GNAQ/GRIA1/CACNA1C/ADCY9/GNG4/ITPR1/ADCY1/NDUFA3/MT-ND1/ADCY2/GNB4/MAPK8/GNB5/MAPK14/GNAO1/MAPK1/NDUFA4L2/DAGLB/ADCY4/GNG7/PRKCG/ADCY7/NDUFB1/GABRB3/CACNA1D/MT-ND5/GRM5/GABRR2/MT-ND6/MAPK11/ADCY5/DAGLA/FAAH/GABRG3	0.330783010189896
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	13/2531	44/9376	1.09450091591538	MAN1C1/MAN2A1/ALG13/HEXD/STT3B/ALG14/MAN1A1/MGAT4A/MAN2A2/ALG11/MGAT4C/TMEM258/CHST8	0.382049798967032
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	13/2531	44/9376	1.09450091591538	CREB5/ADCY3/DYNC2LI1/CREB3L2/ADCY9/DYNC2H1/DYNC1I2/ARHGDIB/DYNC1LI1/RAB5A/AQP3/RAB11A/CREB3L4	0.382049798967032
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	7/2531	23/9376	1.12744575953825	RFC1/MLH1/RFC2/POLD3/RFC3/MSH2/RPA4	0.372099276237442
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	14/2531	49/9376	1.05841846813795	GALNT15/GALNT13/OGT/RFNG/GALNT17/EOGT/GALNT11/FUT10/GXYLT1/GALNT16/C1GALT1C1L/GALNTL6/MFNG/LFNG	0.249299955393785
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	48/2531	174/9376	1.02192127958147	MAP3K5/MAPK10/HSPA1B/DNAJB1/HSPA1A/CRYAB/PPP1R15A/BCL2/EIF2AK3/HSPA6/MAN1C1/BAG2/PRKN/WFS1/ERN1/ATF6/UBXN2A/ATF4/UBE2G2/HSPH1/NFE2L2/RNF185/ERO1B/XBP1/TXNDC5/DNAJA1/UBE2G1/ATXN3/STT3B/BCAP29/MAPK8/SAR1A/RAD23B/SEC24B/DNAJC1/AMFR/SIL1/UBE2D1/HSP90AA1/RRBP1/MAN1A1/UBE2D3/UBXN8/TMEM258/YOD1/HSPA1L/SEL1L2/HSP90AB1	0.177477946570474
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	15/2531	53/9376	1.04843338824985	ESR1/SLC8A1/GNAQ/AP2B1/ADCY9/PTH1R/AP2A2/CLTB/CLTCL1/DNM3/PRKCG/ATP2B4/RAB11A/ATP1B2/KL	0.21500567803063
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	38/2531	138/9376	1.02006997291556	PGR/AR/CAMK2D/RPS6KA2/ADCY3/IGF1/IGF1R/PPP3CB/ADCY9/FBXW11/CPEB4/ITPR1/PPP2CB/ADCY1/PPP2CA/CPEB3/ADCY2/CPEB2/MAPK14/PPP2R1B/ANAPC7/MAPK1/PPP1CB/BTRC/PPP3CA/ANAPC4/PPP2R5D/PPP2R5A/ADCY4/CAMK2G/ADCY7/YWHAZ/SPDYE1/MAPK11/CDK2/ADCY5/CDC23/STAG3	0.144424986359787
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/2531	17/9376	1.08954842308318	CYP7B1/SLC27A5/HSD3B7/CYP46A1/BAAT	0.224704962688165
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/2531	55/9376	1.01030853776804	CERS6/PLPP3/B4GALT5/ACER3/SPTLC2/SGMS2/UGCG/SGPP1/CERS4/ACER2/GALC/SMPD4/PLPP1/SGPL1/SGMS1	0.0466221332964135
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	12/2531	44/9376	1.01030853776804	TAF4B/MNAT1/TAF7/GTF2F2/CCNH/TAF1/GTF2H3/TAF3/TAF4/GTF2A1/TAF5L/TAF5	0.0416755196896761
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	12/2531	44/9376	1.01030853776804	RFC1/POLG2/UNG/RFC2/POLD3/LIG3/HMGB1/POLE/RFC3/POLB/POLE2/NEIL1	0.0416755196896761
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	55/2531	205/9376	0.993880756666121	MT-ATP8/INSR/MT-ND4L/AKT3/MAPK10/MT-ND3/COX7A1/CAMK2D/SMAD3/MT-ND2/PIK3R1/TGFBR1/PTEN/TGFBR2/PDK4/ACE/PIK3CA/NFKB1/NDUFA3/MT-ND1/TGFB2/AKT2/IRS1/MAPK8/MAPK14/TBC1D4/PPP1CB/NDUFA4L2/REN/PLN/PIK3R3/PPARA/SP1/PRKCG/CD36/MT-ATP6/CAMK2G/NCF1/NDUFB1/MTOR/PIK3CB/MT-ND5/PRKCZ/SLC2A1/RYR2/TGFB3/MT-ND6/MAPK11/COX4I2/PRKCD/AGT/CYBB/NCF2/AGER/ATP2A3	-0.0538655739561558
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	10/2531	37/9376	1.00120665904941	GLUL/GLUD1/RIMKLB/ASPA/GLS/CPS1/AGXT2/ABAT/ASRGL1/ALDH5A1	0.00447177798077406
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	15/2531	56/9376	0.992267313879325	MAN1C1/MAN2A1/ALG13/DPM3/STT3B/ALG14/MAN1A1/MGAT4A/MAN2A2/ALG11/MGAT4C/TMEM258/ALG10B/MGAT3/DOLPP1	-0.035290793535662
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	11/2531	41/9376	0.993880756666121	RAD51B/NBN/BABAM2/UIMC1/RBBP8/MRE11/RAD51C/BARD1/RAD52/POLD3/RPA4	-0.023876874415152
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/2531	30/9376	0.98785723692875	MTR/NFKB1/GART/FOLR2/IKBKB/ABCC5/SLC19A1/TNF	-0.0405051499935527
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	19/2531	72/9376	0.977567057377409	MAPK10/NFKBIA/DDX3X/TANK/RIPK1/NFKB1/ZNFX1/ATG5/MAPK8/MAPK14/TRAF6/MAVS/IKBKB/TKFC/MAP3K1/RNF125/MAPK11/TNF/DHX58	-0.116188361540734
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	11/2531	42/9376	0.970216929126451	ACSL1/SLC40A1/MAP1LC3A/ATG5/MAP1LC3B/GCLC/TF/TFRC/MAP1LC3C/CYBB/CP	-0.117626508598108
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/2531	19/9376	0.974859115390214	GUSB/HGSNAT/HYAL1/HPSE2/HPSE	-0.0667012580231976
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	6/2531	23/9376	0.966382079604212	GLUL/GLUD1/GLS/CPS1/ARG1/NOS1	-0.098153158592354
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	6/2531	23/9376	0.966382079604212	LARGE1/B3GALNT2/CRPPA/FKTN/FKRP/B3GAT2	-0.098153158592354
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	41/2531	157/9376	0.967407962915894	FOS/IRS2/INSR/MAP3K5/AKT3/SOCS3/MAPK10/JUN/COX7A1/IL6R/PRKAG2/EIF2AK3/PIK3R1/PPARG/ERN1/PRKAB2/ATF4/PIK3CA/ITCH/NFKB1/NDUFA3/XBP1/RXRA/PRKAA1/AKT2/FAS/IRS1/MAPK8/MAPK14/NR1H3/NDUFA4L2/CASP7/PIK3R3/PPARA/IKBKB/NDUFB1/PIK3CB/LEPR/MAPK11/COX4I2/TNF	-0.250417346357629
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	22/2531	85/9376	0.958802612313199	ENPP1/ADA/UCK2/NT5C2/ADK/ADA2/IMPDH2/CMPK1/AMPD3/CTPS1/ENTPD1/ENTPD6/CTPS2/RRM1/ENTPD3/CDA/ENTPD5/UPP2/NT5M/AK8/GDA/AK9	-0.232002623418373
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	59/2531	227/9376	0.962834421455885	FOS/MT-ATP8/MT-ND4L/MAP3K5/AKT3/MAPK10/MT-ND3/JUN/COX7A1/NOX4/PRKD1/PTPN1/MT-ND2/PIK3R1/ABL2/BRAF/EGFR/NFKBIA/PTEN/PTPN11/PIK3CA/MAP3K14/GSTM5/NFKB1/NFE2L2/GSTT2B/NDUFA3/MT-ND1/SOS2/AKT2/MAP2K4/HGF/ARNT/FOXO3/MAPK8/MAPK14/RAF1/MAPK1/NDUFA4L2/GSTA4/PIK3R3/IKBKB/MT-ATP6/NCF1/SRC/SOS1/NDUFB1/PLD2/GSTM2/PIK3CB/MT-ND5/MT-ND6/AS3MT/MAPK11/COX4I2/PRKCD/NCF2/MET/GSTA1	-0.344676756170943
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	3/2531	12/9376	0.926116159620703	VKORC1L1/COQ5/COQ7	-0.155723575367346
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	26/2531	102/9376	0.944275300005423	ADCY3/PLA2G2A/GNAQ/ADCY9/RAP1B/ITPR1/PLA2G5/ADCY1/ADCY2/RAP1A/TRPC1/ADCY4/PRKCG/ADCY7/ATP2B4/RAB3D/TPCN2/CPB1/RYR2/SLC26A3/RAB11A/ATP1B2/ADCY5/CHRM3/ATP2A3/KCNQ1	-0.34407986859642
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	19/2531	76/9376	0.926116159620703	SORBS1/FABP5/ACSL1/FABP4/ME3/PPARG/APOA2/RXRA/APOC3/NR1H3/SLC27A5/LPL/PPARA/CD36/OLR1/SLC27A1/APOA1/EHHADH/SLC27A6	-0.393241883701171
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	19/2531	76/9376	0.926116159620703	CAMK2D/GNAI1/ADCY3/GNAQ/MYLK/ADCY9/ITPR1/ADCY1/ADCY2/ADCY4/PRKCG/CAMK2G/ADCY7/ATP1B2/ADCY5/SLC26A7/CHRM3/KCNQ1/KCNJ2	-0.393241883701171
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	29/2531	115/9376	0.934169343617405	DUSP1/MAOB/GNAI1/GNAQ/CACNA1C/BRAF/MAOA/KCND2/CYP4X1/GNG4/ITPR1/GNB4/GNB5/HTR2B/GNAO1/TRPC1/RAF1/HTR2A/MAPK1/GNG7/PRKCG/GABRB3/CACNA1D/ALOX5/ALOX15B/PLA2G4A/RAPGEF3/ADCY5/SLC18A2	-0.431909889225539
Organismal Systems	Digestive system	hsa04978	Mineral absorption	15/2531	61/9376	0.910933927495774	MT1G/MT1M/SLC8A1/SLC40A1/CYBRD1/SLC30A1/MT1A/HEPH/MT1H/MT1F/TF/MT1X/ATP2B4/SLC26A3/ATP1B2	-0.424356417481
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	16/2531	65/9376	0.911868218703462	PLPP3/MGLL/ALDH7A1/AGPAT4/LPIN2/DGKH/LPIN1/LPL/DGKA/TKFC/PLPP1/MBOAT1/AGK/LCLAT1/DGKB/LIPC	-0.433546862438421
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/2531	17/9376	0.871638738466544	MTR/INMT/PAPSS2/KYAT1	-0.322098496996299
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/2531	13/9376	0.854876455034495	MRE11/XRCC4/NHEJ1	-0.318380915679782
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	4/2531	18/9376	0.823214364107292	ACSL1/ACACB/CBR4/HSD17B8	-0.456495700695403
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	15/2531	63/9376	0.882015390114955	MNAT1/ERCC1/RFC1/CCNH/XPC/RAD23B/UVSSA/GTF2H3/RFC2/POLR2M/POLD3/POLE/RFC3/RPA4/POLE2	-0.57134156318219
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/2531	35/9376	0.846734774510357	PMM2/GMDS/PFKFB3/FPGT/TKFC/ALDOB/PFKFB2/FBP1	-0.55236474179322
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	38/2531	154/9376	0.914088677028227	UGDH/GUSB/GPHN/PMM2/MTHFD2/UGP2/HSD17B6/CMPK1/PPCDC/VKORC1L1/GCLC/PANK2/CTPS1/MOCS1/COX15/NADK/NAPRT/CTPS2/NADK2/KMO/COQ5/COQ7/AFMID/GCH1/ALAD/LIPT1/IDO2/NMNAT3/NMNAT2/RGN/COX10/HAAO/TPK1/PHOSPHO2/AK8/IDO1/AK9/ALAS2	-0.653646880584454
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/2531	31/9376	0.83649201514128	PRPS2/DERA/RBKS/IDNK/RGN/ALDOB/FBP1	-0.554466286614864
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	7/2531	31/9376	0.83649201514128	GLUL/ACSS1/PCCA/AMT/AFMID/AGXT2/GLDC	-0.554466286614864
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/2531	14/9376	0.79381385110346	B3GNT2/CHST2/B3GNT7	-0.469444408968596
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	35/2531	144/9376	0.90039071074235	MAP3K5/AKT3/MAPK10/RORA/PIK3R1/GNAQ/GRIA1/KCND3/PUM2/ERN1/MCU/PIK3CA/ITPR1/XBP1/ATXN3/AKT2/RB1CC1/ULK2/MAPK8/PUM1/ATXN2/RELN/OPA1/RBPJ/OMA1/PIK3R3/ULK1/SP1/PRKCG/MTOR/PIK3CB/ATXN1L/FGF14/ATP2A3/RYR1	-0.732450321508639
Organismal Systems	Digestive system	hsa04970	Salivary secretion	22/2531	93/9376	0.876324968243246	GUCY1A2/ADCY3/GNAQ/ADCY9/GUCY1B1/ITPR1/ADCY1/ADCY2/GUCY1A1/CST2/LYZ/ADCY4/PRKCG/ADCY7/ATP2B4/RYR3/ADRA1B/CST3/ATP1B2/ADCY5/NOS1/CHRM3	-0.728826766874848
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	59/2531	238/9376	0.918333670884395	FOS/CFD/MAPK10/PLCG2/VWF/JUN/IL6R/C1QA/C1QB/TLR4/STAT3/MASP1/PIK3R1/C7/EGFR/NFKBIA/RPS29/ACE/C1R/C5AR1/ADAM17/PIK3CA/C1QC/C2/NFKB1/MX2/CSF3/CGAS/RPS27/RPL31/FCGR2A/MAPK8/MAPK14/TRAF6/RPL38/MAPK1/PIK3R3/RPL27A/MAVS/PRKCG/OAS2/IKBKB/RPL36A/PIK3CB/ACE2/IL6ST/HBEGF/NLRP3/RPL37/RPL36/C5/MAPK11/TNF/SELP/C6/TLR3/CYBB/RPL37A/SYK	-0.775980701904713
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/2531	28/9376	0.79381385110346	ELOVL5/HADH/PPT2/ELOVL7/ELOVL4/ELOVL2	-0.664391603715769
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	19/2531	82/9376	0.858351562575286	GUSB/UCK2/GSTM5/GSTT2B/DPYD/IMPDH2/CMPK1/GSTA4/CDADC1/RRM1/GSTM2/CYP2A7/CDA/CES1/UPP2/CYP2A6/UPB1/GSTA1/DPYS	-0.783361754862398
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/2531	37/9376	0.800965327239527	UAP1/UGDH/PMM2/GMDS/UGP2/GNPNAT1/GNE/FPGT	-0.737605927288944
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	40/2531	168/9376	0.882015390114955	GLUL/MAPK10/CFLAR/CAMK2D/BCL2/TLR4/STAT3/JAK2/GLUD1/STAT5B/STAT5A/RIPK1/IFNGR1/CHMP4B/TNFAIP3/BIRC2/SPATA2L/TNFSF10/DNM1L/FAS/MAPK8/PYGL/TRAF5/IFNGR2/PYGM/HSP90AA1/CAMK2G/STAT4/NLRP3/CHMP6/HMGB1/PLA2G4A/TNF/IFNG/TLR3/CYBB/SPATA2/USP21/JAK3/HSP90AB1	-0.938301327969395
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/2531	16/9376	0.694587119715527	MAOB/AOC3/MAOA	-0.743454509852651
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	3/2531	16/9376	0.694587119715527	B3GALT5/ST8SIA1/GBGT1	-0.743454509852651
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	57/2531	235/9376	0.898529720823491	MT-ATP8/MT-ND4L/MAP3K5/MT-ND3/CNR1/ZNF516/COX7A1/FGFR1/MGLL/CREB5/RPS6KA2/ACSL1/PRKAG2/ADCY3/MT-ND2/PPARG/MAP2K3/NPR1/CREB3L2/ADCY9/SMARCA2/PRKAB2/NDUFAF2/ADCY1/NDUFA3/MT-ND1/PRKAA1/ATF2/SOS2/ADCY2/SMARCC1/RPS6KB1/ARID1B/MAPK14/ARID1A/RPTOR/KDM3B/KDM1A/NDUFA4L2/COX15/ADCY4/NDUFAF7/MT-ATP6/ADCY7/SOS1/NDUFB1/MTOR/MT-ND5/ATP5ME/BMP8A/CREB3L4/PPARGC1A/COX10/MT-ND6/MAPK11/COX4I2/ADCY5	-0.957901639250693
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/2531	47/9376	0.788183965634641	ME3/ACACB/ACYP2/ALDH7A1/ADH1B/ACYP1/ACSS1/PC/ADH1C/LDHC	-0.885187351953481
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	120/2531	480/9376	0.926116159620703	MT-ATP8/MT-ND4L/DKK1/GPX3/MAP3K5/MAPK10/SNCAIP/MT-ND3/COX7A1/CAMK2D/BCL2/CSF1/NOX4/HIP1/EIF2AK3/TNFRSF1B/MT-ND2/MAP2K3/WNT9A/GNAQ/GRIA1/CACNA1C/BRAF/PRKN/PPP3CB/TUBA1A/ERN1/ATF6/MCU/ATF4/UBE2G2/ITPR1/LRRK2/TANK/PSEN1/LRP6/FUS/MAP1LC3A/WNT2/NFKB1/TARDBP/WDR41/NDUFA3/XBP1/UBE2G1/ATXN3/MT-ND1/KLC1/FAS/RB1CC1/ULK2/ACTR1B/MAPK8/MAPK14/RAB5A/RAF1/CTNNB1/ATXN2/MAP1LC3B/HTT/MAPK1/WNT5B/AXIN1/APC/NDUFA4L2/LRP5/C9orf72/PPP3CA/WNT2B/CASP7/ULK1/DNAH11/PRKCG/MT-ATP6/CAMK2G/RYR3/NDUFB1/SEPTIN5/DNAH7/CACNA1D/MTOR/FIG4/FZD8/MT-ND5/CHRM5/FZD4/ATXN1L/MAP1LC3C/DNAH6/CSNK1A1/RYR2/UBA7/SNCA/GRM5/DNAH9/CASP9/DNAH17/DNAH1/MT-ND6/MAPK11/COX4I2/TNF/DKK2/AXIN2/TUBA3E/FZD3/DNAH3/DNAH12/CYBB/NOS1/KIF5C/DNAH2/AGER/CHRM3/WNT11/ATP2A3/WNT6/RYR1/DNAH10/WNT5A	-1.0104566292444
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	27/2531	117/9376	0.854876455034495	INO80D/SMARCA2/CECR2/GATAD2B/EP400/CHRAC1/BICRAL/SMARCC1/PHF10/GATAD2A/EPC2/ARID1B/SMARCA1/INO80/BAZ2B/ARID1A/SS18/MORF4L2/BAZ2A/BRD9/BAZ1A/TRRAP/UCHL5/MTA3/BRD8/ING3/BPTF	-0.96049199972832
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	9/2531	43/9376	0.775353063868496	PLPP3/PLA2G2A/PLA2G5/ABCA1/APOB/CD36/PLPP1/SLC27A1/APOA1	-0.897778248868949
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	6/2531	30/9376	0.740892927696563	PIGU/PGAP1/PIGA/PIGN/PIGL/PGAP3	-0.864314881749626
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/2531	26/9376	0.712397045862079	PLA2G2A/PLA2G6/PLA2G5/PLA2G4A/PLB1	-0.892933662661397
NA	NA	hsa03272	Virion - Hepatitis viruses	10/2531	48/9376	0.771763466350586	CLDN5/EGFR/IST1/CHMP4B/HSPG2/PDCD6IP/CLDN4/SLC10A1/CLDN10/CLDN7	-0.963954416278055
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	14/2531	66/9376	0.785795529375142	CYP7B1/HSD17B11/STS/HSD17B6/CYP11A1/LRTOMT/HSD3B1/SULT2B1/HSD17B2/CYP19A1/CYP3A5/HSD17B8/DHRS11/HSD11B2	-1.06186826703557
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7/2531	36/9376	0.72031256859388	UGDH/GUSB/FGGY/UGP2/CRPPA/CRYL1/KL	-1.02234092747676
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	7/2531	36/9376	0.72031256859388	ENPP1/GANC/UGP2/PYGL/AGL/PYGM/TREH	-1.02234092747676
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/2531	27/9376	0.68601197008941	ELOVL5/ELOVL7/ELOVL4/BAAT/ELOVL2	-0.993475996707038
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/2531	79/9376	0.797163276635542	ATP6V0A1/AP2B1/SYT1/STX2/AP2A2/CLTB/UNC13B/CLTCL1/SLC1A2/STXBP1/DNM3/ATP6V1E2/SLC1A3/SLC6A2/SLC1A1/ATP6V1C2/SLC18A2	-1.10086407905828
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	11/2531	54/9376	0.754613167098351	MTR/AMD1/AHCY/BHMT2/GCLC/KYAT1/SDS/DNMT1/CDO1/AGXT2/LDHC	-1.09960972109536
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/2531	50/9376	0.740892927696563	MAOB/AOC1/CKB/ALDH7A1/MAOA/AMD1/CKMT2/GATM/ARG1/NOS1	-1.11702154114935
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/2531	23/9376	0.644254719736141	GLUD1/GLS/AQP1/ATP1B2	-1.03865802825195
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	59/2531	250/9376	0.874253654681944	MITF/LITAF/CTSK/OSBPL5/CTSH/ATP6V0A1/NCOA7/DEPTOR/GUSB/AP2B1/LAPTM5/VPS13C/ARSG/SUMF1/STX17/SORT1/CTSS/TFE3/AP1M1/AP2A2/VPS13A/OSBPL3/HGSNAT/CTSC/CLTB/OSBP/AP1G1/DMXL1/LIPA/NPC1/DTNBP1/ARL8B/CLTCL1/BORCS5/RPTOR/BLOC1S5/WDR7/GGA3/GALC/ATP6V1E2/AP4S1/PPT2/SLC11A1/ACP5/SLC36A1/PIKFYVE/TPCN1/SLC29A1/OSBPL2/MTOR/FIG4/RAB7A/TPCN2/HYAL1/AP4B1/CTSW/TLR3/LAPTM4A/ATP6V1C2	-1.22537813931254
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	7/2531	37/9376	0.700844661334586	MAOB/AOC3/AOX1/MAOA/ADH1B/LRTOMT/ADH1C	-1.1086447799238
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/2531	28/9376	0.661511542586217	GPHN/PCBD1/MOCS1/GCH1/PCBD2	-1.0907080338033
NA	NA	hsa04082	Neuroactive ligand signaling	46/2531	199/9376	0.856308408895525	ADRA2C/GNAI1/P2RY14/ADCY3/GNAQ/GRIA1/TAC3/ADCY9/GNG4/ADCY1/GRM7/P2RX4/ADCY2/OGFRL1/GNB4/GNB5/HTR2B/GABBR1/GNAL/GNAO1/HTR2A/HRH1/SLC1A2/ADRA2A/ADCY4/GNG7/PRKCG/P2RY1/ADCY7/GABRB3/ADRA1B/SLC1A3/CHRM5/SLC6A2/SLC17A9/GRM5/POMC/GABRR2/GRIK2/ADCY5/TACR1/SLC1A1/CHRM3/SLC18A2/GRM8/GABRG3	-1.24581200249095
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	65/2531	275/9376	0.875600732732301	MT-ATP8/EGR1/MT-ND4L/MAPK10/HSPA1B/MT-ND3/COX7A1/HSPA1A/C1QA/CREB5/C1QB/EIF2AK3/MT-ND2/HSPA6/PIK3R1/C7/CACNA1C/CREB3L2/PPP3CB/TUBA1A/CAV1/MCU/ATF4/PIK3CA/C1QC/ITPR1/NDUFA3/LAMC1/MT-ND1/NOTCH1/ATF2/KLC1/MAPK8/MAPK14/MAPK1/CCL5/NDUFA4L2/PPP3CA/PIK3R3/MT-ATP6/NCF1/FYN/RYR3/NDUFB1/NCAM2/CACNA1D/PIK3CB/MT-ND5/RYR2/CASP9/CREB3L4/HSPA1L/MT-ND6/C5/MAPK11/COX4I2/PRKCD/NCAM1/TNF/C6/TUBA3E/CYBB/KIF5C/NCF2/RYR1	-1.27316472282095
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	15/2531	73/9376	0.761191364071811	MAOB/AOX1/MAOA/ADH1B/GSTM5/GSTT2B/GSTA4/GSTM2/CYP2A7/FMO4/FMO2/CYP3A5/ADH1C/CYP2A6/GSTA1	-1.24550344198911
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	7/2531	38/9376	0.68240138077315	UAP1/UGDH/PMM2/UGP2/GNPNAT1/GNE/FPGT	-1.19285719293302
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	88/2531	368/9376	0.885850239637194	MT-ATP8/MT-ND4L/GPX3/MAP3K5/MT-ND3/COX7A1/BCL2/NUP153/EIF2AK3/TNFRSF1B/MT-ND2/MAP2K3/NUP98/ANG/GRIA1/SRSF7/PRKN/PPP3CB/TUBA1A/ERN1/ATF6/MCU/ATF4/TANK/FUS/MAP1LC3A/TARDBP/WDR41/NDUFA3/XBP1/NXF1/MT-ND1/KLC1/RB1CC1/ULK2/ACTR1B/NUP214/MAPK14/SEH1L/RAB5A/ATXN2/HNRNPA3/MAP1LC3B/NRG3/ANXA11/NUP54/SLC1A2/NDUFA4L2/NUP85/HNRNPA2B1/C9orf72/PPP3CA/ULK1/DNAH11/MT-ATP6/NUP43/NUP50/NDUFB1/DNAH7/MTOR/FIG4/MT-ND5/MAP1LC3C/DNAH6/NCBP1/DNAH9/NUP210L/NUP155/CASP9/NUP35/DNAH17/DNAH1/MT-ND6/MAPK11/COX4I2/TNF/NUP205/NRG1/TUBA3E/DNAH3/DNAH12/NOS1/KIF5C/MATR3/DNAH2/NRG2/NUP210/DNAH10	-1.35840636931271
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	93/2531	388/9376	0.887925802522942	MT-ATP8/IRS2/INSR/MT-ND4L/DKK1/MAP3K5/AKT3/MAPK10/MT-ND3/COX7A1/CSF1/NOX4/EIF2AK3/MT-ND2/PIK3R1/WNT9A/GNAQ/CACNA1C/BRAF/APOE/PPP3CB/TUBA1A/ERN1/ATF6/MCU/ADAM17/ATF4/SLC39A10/PIK3CA/ITPR1/PSEN1/LRP6/WNT2/NFKB1/NDUFA3/XBP1/MT-ND1/KLC1/AKT2/FAS/IRS1/RB1CC1/ULK2/MAPK8/SLC39A11/RTN3/RAF1/CTNNB1/MME/MAPK1/WNT5B/AXIN1/APC/NDUFA4L2/LRP5/PPP3CA/WNT2B/CASP7/LPL/PIK3R3/IDE/ULK1/IKBKB/MT-ATP6/RYR3/NDUFB1/CACNA1D/MTOR/FZD8/PIK3CB/MT-ND5/CHRM5/FZD4/CSNK1A1/SNCA/GRM5/CASP9/MT-ND6/COX4I2/TNF/DKK2/AXIN2/TUBA3E/FZD3/CYBB/NOS1/KIF5C/AGER/CHRM3/WNT11/ATP2A3/WNT6/WNT5A	-1.37099210286367
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	8/2531	43/9376	0.689202723438663	ACSL1/ALDH7A1/ADH1B/HADH/CYP2U1/ACADSB/ADH1C/EHHADH	-1.24206917534428
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/2531	48/9376	0.694587119715527	AKT3/PIK3R1/PIK3CA/AKT2/PIK3R3/CACNA1D/PIK3CB/ATP1B2/SLC2A5	-1.28990784267098
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	11/2531	57/9376	0.71489668461949	ACSL1/ELOVL5/HADH/CBR4/PPT2/ELOVL7/ACADSB/HSD17B8/ELOVL4/EHHADH/ELOVL2	-1.31280440151589
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	5/2531	30/9376	0.617410773080469	PLA2G2A/PLA2G6/PLA2G5/PLA2G4A/PLB1	-1.27621974762766
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/2531	15/9376	0.493928618464375	TPK1/AK8	-1.1927276025911
NA	NA	hsa04382	Cornified envelope formation	49/2531	217/9376	0.83649201514128	COL4A1/COL4A2/KAZN/S100A4/ITGA6/COL4A4/LAMA3/ABHD5/TJP1/SPTLC2/CLDN5/COL4A3/PCSK6/KRT7/PPP2CB/UGCG/PPP2CA/PPP2R3A/S100A8/PPP2R2A/PPP2R2D/PPP2R1B/S100A3/S100A9/CLDN4/PPP2R5D/PPP2R5A/TCHH/KRT5/DSP/CYP4F22/PKP2/SLC27A1/JUP/DST/ITGB4/KRT85/COL17A1/PRSS8/PPP2R3B/KRT23/PPL/CLDN10/CDSN/ELOVL4/CLDN7/S100A12/PPP2R2B/KRT34	-1.48180067439398
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	5/2531	31/9376	0.597494296529486	UGDH/GUSB/ALDH7A1/RGN/KL	-1.36492320504981
NA	NA	hsa04981	Folate transport and metabolism	5/2531	31/9376	0.597494296529486	MTR/BHMT2/FOLR2/ABCC5/SLC19A1	-1.36492320504981
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	11/2531	59/9376	0.690662898700185	GPX3/GGT5/ANPEP/GSTM5/GSTT2B/GCLC/GSTA4/LANCL1/RRM1/GSTM2/GSTA1	-1.44932223214237
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	43/2531	195/9376	0.816881945921851	AKT3/PLCG2/VWF/TLR4/PIK3R1/HDAC4/HDAC7/C5AR1/PIK3CA/NFKB1/AKT2/FCGR2A/MAPK14/RAF1/MAPK1/HDAC5/ITGB2/PIK3R3/PRKCG/NCF1/SRC/HDAC11/MTOR/PIK3CB/FPR3/HDAC9/HMGB1/ELANE/HDAC10/C5/MAPK11/SELP/FCGR3A/CYBB/CR1L/NCF2/CLEC7A/AGER/CLCN4/ITGAL/AQP9/SYK/ITGAM	-1.57126147054312
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/2531	10/9376	0.370446463848281	PAPSS2	-1.21115736791041
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/2531	51/9376	0.653729053849908	PLCG2/ATP6V0A1/ADCY3/TJP1/TJP2/ADCY9/ATP6V1E2/ATP6V1C2/KCNQ1	-1.50772350691489
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	30/2531	143/9376	0.777160413667723	HLA-DRA/C1QA/C1QB/HLA-DPA1/HLA-DPB1/HLA-DRB1/C7/ACTN4/HLA-DQB1/C1R/C1QC/HLA-DQA1/C2/HLA-DMA/HLA-DRB5/FCGR2A/CD40/HLA-DQA2/HLA-DMB/IL10/ELANE/HLA-DOA/C5/TNF/IFNG/CD80/C6/FCGR3A/TRIM21/CD86	-1.63280352421544
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/2531	33/9376	0.561282520982245	DLST/BCKDHB/DHTKD1/AADAT/AGXT2	-1.53512490539465
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/2531	28/9376	0.529209234068973	B3GNT2/B3GALT5/ST8SIA1/GCNT2	-1.51702446389084
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/2531	18/9376	0.411607182053646	HEXD/MAN2C1	-1.5193473743284
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	84/2531	370/9376	0.841013593601504	LPAR1/PRLR/ADRA2C/CNR1/ADM/EDNRB/CALCRL/P2RY14/F2R/CSH1/GRIA1/PTGER3/S1PR3/TAC3/GHR/C5AR1/AVPR1A/GRID1/PTH1R/OXTR/VIPR2/EDNRA/GRM7/P2RX4/CSH2/OGFRL1/HTR2B/GABBR1/S1PR2/RXFP1/HTR2A/PTGER2/LPAR6/HRH1/ADRA2A/F2RL2/P2RY1/TSHR/EDN1/NPY1R/P2RX7/THRB/CGA/GABRB3/ADRA1B/CHRM5/PTGER4/OXT/GZMA/FPR3/GLP2R/LYNX1/LEPR/GRP/LHCGR/GRM5/KISS1/POMC/GABRR2/NPW/P2RY8/S1PR1/GRIK2/C5/LTB4R/TRPV1/CYSLTR2/GRID2/PTH2R/LPAR2/KNG1/AGT/TACR1/MCHR1/APLNR/CHRNA5/CHRM3/TBXA2R/CHRNE/LYPD6/GRM8/UTS2B/NPFF/GABRG3	-1.89731687004162
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	15/2531	83/9376	0.669481561171593	SAMHD1/CCL4/NFKBIA/CCL4L2/RIPK1/NFKB1/CGAS/CCL5/CASP7/MAVS/IKBKB/POLR3E/NLRP3/IL18/ZCCHC3	-1.83908479969351
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	72/2531	323/9376	0.825763015389358	TIMP3/ZEB1/IRS2/THBS1/MCL1/TNXB/PIM1/PLCG2/PDGFRB/MYC/HOXD10/BCL2/PDCD4/STAT3/CCND2/TNC/PIK3R1/CD44/PLAU/MDM4/EGFR/PRKCE/NOTCH3/PTEN/GLS/HDAC4/ROCK1/ZFPM2/DICER1/FOXP1/SIRT1/PIK3CA/CREBBP/VIM/TPM1/PDGFRA/NFKB1/RECK/RASSF1/NOTCH1/SOS2/TGFB2/IRS1/SLC7A1/RAF1/RPS6KA5/MAPK1/RPTOR/APC/BMI1/HDAC5/BMPR2/SPRY2/PIK3R3/TP63/ERBB2/DNMT1/PRKCG/IKBKB/ABCB1/CDKN1B/EZH2/SOS1/PDGFB/MTOR/PIK3CB/SOCS1/NOTCH4/EFNA1/ITGA5/FZD3/MET	-1.93771692216098
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/2531	46/9376	0.563722879769124	GUSB/HEPH/COX15/ALAD/COX10/CP/ALAS2	-1.80362196781986
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	22/2531	116/9376	0.702570879712258	ME3/PRPS2/GLUD1/DLST/HIBCH/ACSS1/PCCA/ALDH6A1/AMT/SUCLG2/SDS/IDNK/TKFC/PC/PSPH/CPS1/RGN/ALDOB/ENO3/AGXT2/FBP1/GLDC	-1.95998150122477
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/2531	20/9376	0.370446463848281	LIPA/SOAT1	-1.71375029864206
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/2531	26/9376	0.427438227517248	HES1/NR5A2/HHEX	-1.77765795951369
Organismal Systems	Digestive system	hsa04976	Bile secretion	16/2531	90/9376	0.658571491285833	ADCY3/ADCY9/ADCY1/RXRA/ADCY2/SLC27A5/ADCY4/AQP1/ABCB1/ADCY7/SLC2A1/ATP1B2/SLC10A1/ADCY5/BAAT/AQP9	-1.97902682412387
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/2531	63/9376	0.588010260076637	GGT5/PLA2G2A/HPGD/PLA2G6/PLA2G5/CYP2U1/ALOX5/ALOX15B/PLA2G4A/PLB1	-1.99506412109327
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	14/2531	83/9376	0.624849457093486	ACSL1/FAR1/ABCD2/FAR2/PEX19/NUDT7/AGPS/PEX1/PEX5/NUDT12/PEX7/EHHADH/BAAT/PXMP4	-2.08742865754103
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	3/2531	28/9376	0.39690692555173	ATP6V0A1/ATP6V1E2/ATP6V1C2	-1.94334089397837
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/2531	29/9376	0.38322047984305	SLC24A1/RCVRN/RGS9	-2.02272949319194
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/2531	23/9376	0.322127359868071	PDSS2/PDSS1	-1.97916289791154
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/2531	30/9376	0.370446463848281	DLST/SUCLG2/PC	-2.10002947938373
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	10/2531	68/9376	0.54477421154159	ALDH1A1/ALDH1A2/AOX1/ADH1B/HSD17B6/CYP26B1/CYP2A7/CYP3A5/ADH1C/CYP2A6	-2.29085768518559
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	63/2531	308/9376	0.75773140332603	MT-ATP8/MT-ND4L/TGM2/GPX3/MAP3K5/MAPK10/MT-ND3/COX7A1/CREB5/HIP1/MT-ND2/PPARG/GNAQ/GRIA1/CREB3L2/AP2B1/TUBA1A/ERN1/TAF4B/CREBBP/ITPR1/NDUFA3/SIN3A/AP2A2/MT-ND1/KLC1/RB1CC1/ULK2/ACTR1B/MAPK8/CLTB/HTT/CLTCL1/SLC1A2/NDUFA4L2/RCOR1/TAF4/ULK1/SP1/DNAH11/MT-ATP6/BBC3/NDUFB1/DNAH7/MTOR/SLC1A3/MT-ND5/DNAH6/GRM5/DNAH9/CASP9/DNAH17/CREB3L4/PPARGC1A/DNAH1/MT-ND6/COX4I2/TUBA3E/DNAH3/DNAH12/KIF5C/DNAH2/DNAH10	-2.62882520900154
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	13/2531	87/9376	0.553540693106627	CACNB2/COX7A1/SLC8A1/CACNA1C/TPM1/MYL3/CACNA1D/RYR2/ATP1B2/CACNB1/COX4I2/SLC9A6/ATP2A3	-2.54391156749388
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/2531	34/9376	0.326864526924954	POLR1E/POLR2M/POLR3E	-2.39093070462327
Genetic Information Processing	Transcription	hsa03040	Spliceosome	47/2531	243/9376	0.716501390982273	HSPA1B/HSPA1A/TRA2B/HSPA6/RBM25/SRSF7/DDX5/TRA2A/HNRNPU/RBMX/EIF4A3/HNRNPC/RBM17/FUS/THOC2/CWC25/SF1/SNW1/TCERG1/U2SURP/SRSF10/THOC1/CDC5L/WBP11/HNRNPM/DDX42/PRPF18/RBMX2/SNIP1/SRSF5/SNRNP70/SRSF4/ACIN1/CASC3/SF3B3/HNRNPA3/SYF2/THOC6/PRPF3/SRSF6/CHERP/CRNKL1/U2AF1L4/RBMXL1/NCBP1/BUD13/HSPA1L	-2.72265319132791
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	4/2531	41/9376	0.361411184242226	GRIA1/GABRB3/GABRR2/GABRG3	-2.49173045176198
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/2531	75/9376	0.493928618464375	GLUL/MTR/PRPS2/SDS/PC/PSPH/CPS1/ALDOB/ENO3/ARG1	-2.67560853464187
Organismal Systems	Sensory system	hsa04742	Taste transduction	12/2531	86/9376	0.516902042578997	PDE1A/CACNA1C/GABBR1/ADCY4/P2RY1/ASIC2/SCN3A/SCNN1B/PKD1L3/CHRM3/PDE1C/TAS2R14	-2.73666447394024
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	8/2531	67/9376	0.442324135938246	ALDH7A1/ADH1B/ACSS1/ALDOB/ADH1C/ENO3/LDHC/FBP1	-2.7855612965178
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/2531	31/9376	0.238997718611794	IMMP2L/IMMP1L	-2.58060858270223
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	10/2531	79/9376	0.468919574491495	ADH1B/GSTM5/GSTT2B/GSTA4/GSTM2/CYP2A7/CYP3A5/ADH1C/CYP2A6/GSTA1	-2.88235460441157
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/2531	32/9376	0.231529039905176	GANC/UGP2	-2.64777464659559
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/2531	70/9376	0.423367387255179	GSTM5/GSTT2B/GSTA4/GSTM2/CYP2A7/CYP3A5/CYP2A6/GSTA1	-2.94450083419082
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	21/2531	138/9376	0.563722879769124	MT-ATP8/MT-ND4L/MT-ND3/COX7A1/ATP6V0A1/MT-ND2/PPA1/NDUFA3/LHPP/MT-ND1/NDUFA4L2/COX15/ATP6V1E2/MT-ATP6/NDUFB1/MT-ND5/ATP5ME/COX10/MT-ND6/COX4I2/ATP6V1C2	-3.13948192175135
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	49/2531	268/9376	0.67730883315544	MT-ATP8/MT-ND4L/DUSP1/MAP3K5/MAOB/MAPK10/SNCAIP/MT-ND3/COX7A1/CAMK2D/GNAI1/EIF2AK3/MT-ND2/PRKN/TUBA1A/MAOA/ERN1/ATF6/MCU/ATF4/UBE2G2/SLC39A10/ITPR1/LRRK2/NFE2L2/NDUFA3/XBP1/UBE2G1/MT-ND1/KLC1/MAPK8/GNAL/SLC39A11/NDUFA4L2/MT-ATP6/CAMK2G/RYR3/NDUFB1/SEPTIN5/MT-ND5/UBA7/SNCA/CASP9/MT-ND6/COX4I2/ADCY5/TUBA3E/KIF5C/SLC18A2	-3.25902692168668
Human Diseases	Substance dependence	hsa05034	Alcoholism	31/2531	191/9376	0.601248187397734	FOSB/MAOB/CREB5/GNAI1/BRAF/CREB3L2/HDAC4/CAMKK2/MAOA/HDAC7/GNG4/ATF4/ATF2/SOS2/GNB4/GNB5/GNAO1/RAF1/MAPK1/PPP1CB/HDAC5/GNG7/SOS1/HDAC11/SLC29A1/HDAC9/NTRK2/HDAC10/CREB3L4/ADCY5/SLC18A2	-3.385515122735
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	3/2531	46/9376	0.241595519901053	PSME4/PSME1/IFNG	-3.13533512845136
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	19/2531	183/9376	0.384616547164882	NOP58/WDR43/GNL2/RCL1/RIOK1/XRN1/MDN1/NXF1/NMD3/UTP6/FCF1/HEATR1/RBM28/REXO2/GNL3L/DROSHA/RMRP/REXO5/NOL6	-5.11196313912536
Genetic Information Processing	Translation	hsa03010	Ribosome	14/2531	222/9376	0.233614887111529	RPS29/MRPS31/RPS27/RPL31/MRPL33/RPL38/MRPS27/MRPS28/RPL27A/RPL36A/MRPL1/RPL37/RPL36/RPL37A	-7.02688874736301
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	15/2531	449/9376	0.123757170550651	PDE1A/RGS2/CAMK2D/SLC8A1/ADCY3/NCALD/GNAL/ANO2/GNG7/CAMK2G/GRK2/ARRB2/PDE2A/GRK3/PDE1C	-11.5701733200709