category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	6/30	204/9376	9.1921568627451	TIMP3/FN1/EZR/EGFR/ITGA5/ITGB1	6.70215854865271
NA	NA	hsa04518	Integrin signaling	5/30	154/9376	10.1471861471861	FLT1/FN1/EGFR/ITGA5/ITGB1	6.48438355722085
NA	NA	hsa04517	IgSF CAM signaling	6/30	299/9376	6.27157190635451	RASA1/IL1RAP/EZR/PARD3/ITGA5/ITGB1	5.24853307660981
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	4/30	110/9376	11.3648484848485	FLT1/SERPINE1/EPAS1/EGFR	6.19507444742431
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	5/30	203/9376	7.69786535303777	FLT1/FN1/EGFR/ITGA5/ITGB1	5.46590541435606
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	6/30	333/9376	5.63123123123123	TCF7L2/FN1/EGFR/PARD3/ITGA5/ITGB1	4.87523656125726
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	5/30	232/9376	6.73563218390805	FN1/EZR/EGFR/ITGA5/ITGB1	5.0117633278172
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/30	78/9376	12.0205128205128	FN1/ITGA5/ITGB1	5.53716814506204
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	3/30	86/9376	10.9023255813953	TCF7L2/ITGA5/ITGB1	5.22651194579718
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	3/30	89/9376	10.5348314606742	FN1/ITGA5/ITGB1	5.12039751985565
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	3/30	93/9376	10.0817204301075	TCF7L2/EGFR/PARD3	4.98653423235853
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	4/30	200/9376	6.25066666666667	EZR/TNFSF10/MYO1E/ITGB1	4.25241969599732
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	4/30	212/9376	5.89685534591195	FLT1/EGFR/PARD3/ITGB1	4.08579001249563
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	5/30	362/9376	4.31675874769797	FLT1/FN1/EGFR/ITGA5/ITGB1	3.64621915996566
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	4/30	233/9376	5.3653791130186	FN1/ITGA5/ITGB1/FMNL2	3.82286484424538
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	2/30	37/9376	16.8936936936937	TCF7L2/PPARG	5.48793413603262
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	4/30	238/9376	5.25266106442577	FLT1/RASA1/EGFR/RASAL2	3.76493124775755
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	3/30	138/9376	6.79420289855072	FN1/ITGA5/ITGB1	3.8848802869407
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	3/30	157/9376	5.97197452229299	TCF7L2/SERPINE1/PARD3	3.55934586179361
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	4/30	300/9376	4.16711111111111	FLT1/RASA1/IL1RAP/EGFR	3.15871222235132
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	2/30	59/9376	10.5943502824859	TCF7L2/EGFR	4.18829154868383
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	3/30	170/9376	5.51529411764706	EZR/PARD3/ITGB1	3.36595571137692
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	4/30	323/9376	3.8703818369453	TIMP3/EZR/EGFR/ITGA5	2.97425398036129
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/30	184/9376	5.09565217391304	RASA1/PARD3/ITGB1	3.17877909065246
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/30	194/9376	4.83298969072165	DNAH11/MYO1E/KIF21A	3.05635114609807
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	2/30	78/9376	8.01367521367521	ITGA5/ITGB1	3.52396477418792
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	3/30	201/9376	4.66467661691542	FLT1/AFF1/PPARG	2.97552789853028
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/30	87/9376	7.18467432950192	TCF7L2/EGFR	3.28341182335762
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	2/30	93/9376	6.72114695340502	FN1/ITGB1	3.14133157379852
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/30	99/9376	6.31380471380471	ITGA5/ITGB1	3.01129141460271
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	2/30	101/9376	6.18877887788779	SERPINE1/FN1	2.97031335847564
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	2/30	105/9376	5.95301587301587	ITGA5/ITGB1	2.89157496486703
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	2/30	106/9376	5.89685534591195	TCF7L2/EGFR	2.87252434342506
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	3/30	253/9376	3.70592885375494	EGFR/ITGA5/ITGB1	2.47195849196898
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/30	15/9376	20.8355555555556	HEXB	4.35574305515158
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/30	16/9376	19.5333333333333	HEXB	4.2034799577576
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	2/30	116/9376	5.38850574712644	EZR/ITGB1	2.69447122450743
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/30	18/9376	17.362962962963	HEXB	3.93677012872706
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/30	19/9376	16.4491228070175	HEXB	3.81896508995184
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	2/30	133/9376	4.69974937343358	TNFSF10/EGFR	2.43458547412761
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	3/30	298/9376	3.14630872483221	IL1RAP/TNFSF10/IL1RL1	2.13323456041268
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	3/30	308/9376	3.04415584415584	DNAH11/MT-ATP8/PPARG	2.06665023888121
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	2/30	148/9376	4.22342342342342	TCF7L2/EGFR	2.23938002189507
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/30	150/9376	4.16711111111111	TCF7L2/EGFR	2.21531547629552
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	2/30	155/9376	4.03268817204301	ITGA5/ITGB1	2.15693954466868
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	2/30	155/9376	4.03268817204301	TCF7L2/EGFR	2.15693954466868
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/30	31/9376	10.0817204301075	IMMP2L	2.86941060986248
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	2/30	170/9376	3.67686274509804	TCF7L2/EGFR	1.99548494752986
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/30	38/9376	8.22456140350877	HEXB	2.5281901056502
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	1/30	41/9376	7.62276422764228	EGFR	2.40772808564407
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	1/30	42/9376	7.44126984126984	SAT1	2.37025797991337
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/30	44/9376	7.1030303030303	HEXB	2.29888833578874
NA	NA	hsa04519	Cadherin signaling	3/30	404/9376	2.32079207920792	TCF7L2/EGFR/MYO1E	1.53749560540455
NA	NA	hsa03272	Virion - Hepatitis viruses	1/30	48/9376	6.51111111111111	EGFR	2.16869707763848
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/30	50/9376	6.25066666666667	SAT1	2.10904148406304
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	2/30	216/9376	2.89382716049383	TNFSF10/PPARG	1.5953385390275
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	1/30	55/9376	5.68242424242424	HEXB	1.97312331141482
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	2/30	227/9376	2.75359765051395	MT-ATP8/EGFR	1.51526798329866
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/30	56/9376	5.58095238095238	MGAT5	1.94793836796115
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/30	235/9376	2.65985815602837	MT-ATP8/PPARG	1.45996159182822
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	1/30	63/9376	4.96084656084656	TCF7L2	1.78709182876343
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	2/30	248/9376	2.52043010752688	TCF7L2/TNFSF10	1.37479474311499
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	2/30	250/9376	2.50026666666667	EGFR/PARD3	1.36217093514119
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	2/30	254/9376	2.46089238845144	FLT1/EGFR	1.33728332071284
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	1/30	68/9376	4.59607843137255	TCF7L2	1.68612124886079
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	1/30	70/9376	4.4647619047619	EPAS1	1.6484442681894
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/30	71/9376	4.4018779342723	EGFR	1.63013318709402
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	1/30	71/9376	4.4018779342723	EGFR	1.63013318709402
Human Diseases	Cancer: specific types	hsa05218	Melanoma	1/30	73/9376	4.28127853881278	EGFR	1.59450687024501
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	1/30	73/9376	4.28127853881278	EGFR	1.59450687024501
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	1/30	75/9376	4.16711111111111	SERPINE1	1.56013610185461
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	1/30	76/9376	4.11228070175439	PPARG	1.54339631466192
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	1/30	76/9376	4.11228070175439	EZR	1.54339631466192
Human Diseases	Cancer: specific types	hsa05214	Glioma	1/30	76/9376	4.11228070175439	EGFR	1.54339631466192
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	1/30	77/9376	4.05887445887446	EGFR	1.52694104439299
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	1/30	78/9376	4.00683760683761	ITGB1	1.51076140331381
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	1/30	80/9376	3.90666666666667	EGFR	1.47919538575121
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	1/30	86/9376	3.63410852713178	EGFR	1.39029963925308
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	1/30	88/9376	3.55151515151515	SERPINE1	1.36242235660326
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	1/30	89/9376	3.51161048689139	EGFR	1.34878567712122
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	1/30	90/9376	3.47259259259259	PPARG	1.33534306756048
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	1/30	90/9376	3.47259259259259	EGFR	1.33534306756048
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	1/30	93/9376	3.36057347670251	EGFR	1.29612891523851
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	1/30	95/9376	3.28982456140351	FLT1	1.27086670807622
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	1/30	99/9376	3.15690235690236	EGFR	1.22229963261595
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	1/30	99/9376	3.15690235690236	IL1RAP	1.22229963261595
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	1/30	99/9376	3.15690235690236	EGFR	1.22229963261595
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	1/30	100/9376	3.12533333333333	TNFSF10	1.21054255448383
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	1/30	100/9376	3.12533333333333	ITGA5	1.21054255448383
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	1/30	101/9376	3.09438943894389	TCF7L2	1.19893197893947
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	1/30	103/9376	3.03430420711974	SERPINE1	1.17613657836761
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	1/30	103/9376	3.03430420711974	FN1	1.17613657836761
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	1/30	109/9376	2.86727828746177	IL1RAP	1.11092845800031
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	1/30	110/9376	2.84121212121212	LTBP1	1.10049328565519
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	1/30	112/9376	2.79047619047619	ITGB1	1.07996993526794
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	1/30	115/9376	2.71768115942029	KCND2	1.05001597708468
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	1/30	115/9376	2.71768115942029	EGFR	1.05001597708468
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	1/30	122/9376	2.56174863387978	PPARG	0.983693223679115
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	1/30	122/9376	2.56174863387978	MED13L	0.983693223679115
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	2/30	368/9376	1.69855072463768	DNAH11/MT-ATP8	0.774534995875636
Organismal Systems	Immune system	hsa04611	Platelet activation	1/30	126/9376	2.48042328042328	ITGB1	0.947837068673979
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	1/30	130/9376	2.40410256410256	EGFR	0.913328355801371
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1/30	133/9376	2.34987468671679	TNFSF10	0.88827241319952
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	1/30	137/9376	2.28126520681265	TNFSF10	0.855894449814136
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/30	138/9376	2.26473429951691	MT-ATP8	0.847975370286038
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	1/30	139/9376	2.2484412470024	EGFR	0.84012404422638
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	1/30	140/9376	2.23238095238095	SERPINE1	0.832339317804386
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	1/30	142/9376	2.20093896713615	PPARG	0.816965187918098
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	1/30	144/9376	2.17037037037037	TCF7L2	0.801844295378836
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	1/30	149/9376	2.09753914988814	EGFR	0.765096599718614
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	1/30	154/9376	2.02943722943723	EGFR	0.72976167056655
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/30	156/9376	2.0034188034188	EGFR	0.715999058165182
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	1/30	157/9376	1.99065817409766	PPARG	0.709194115258733
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	1/30	157/9376	1.99065817409766	SERPINE1	0.709194115258733
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	1/30	157/9376	1.99065817409766	PPARG	0.709194115258733
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	1/30	160/9376	1.95333333333333	ITGB1	0.689075666621653
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	1/30	168/9376	1.86031746031746	TNFSF10	0.637476383054397
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	1/30	168/9376	1.86031746031746	EGFR	0.637476383054397
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	1/30	173/9376	1.80655105973025	TNFSF10	0.606629580977787
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	1/30	178/9376	1.75580524344569	TCF7L2	0.576775197122135
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	1/30	180/9376	1.7362962962963	ITGA5	0.565096691176383
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	2/30	480/9376	1.30222222222222	DNAH11/MT-ATP8	0.385108410467479
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	1/30	193/9376	1.61934369602763	PARD3	0.492551290258267
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	1/30	196/9376	1.59455782312925	TCF7L2	0.476578197301425
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	1/30	205/9376	1.52455284552846	MT-ATP8	0.430220606618804
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	1/30	217/9376	1.44024577572965	EGFR	0.371735820802104
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	1/30	227/9376	1.37679882525698	EGFR	0.325588481422237
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	1/30	238/9376	1.31316526610644	EGFR	0.277248922078312
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	1/30	250/9376	1.25013333333333	HEXB	0.227109196082907
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	1/30	268/9376	1.16616915422886	MT-ATP8	0.15636504445273
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	1/30	275/9376	1.13648484848485	MT-ATP8	0.130148632401043
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	1/30	388/9376	0.805498281786942	MT-ATP8	-0.221687471682786