category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	23/478	169/9376	2.66950558292689	CTSL/PIK3R1/DAPK1/MAPK8/ATG13/RAB8A/PIK3CB/ATG101/SNAP29/DAPK3/WDR45/EIF2AK4/RRAS/MTMR3/RPS6KB1/VPS39/VPS41/EPG5/AKT1S1/ATG5/TBK1/MTMR4/SUPT20H	5.07604591980875
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/478	78/9376	3.52065229052677	FN1/ITGA5/ITGB1/CLTB/CDH1/SEPTIN9/PIK3R1/ARPC1A/WASL/PIK3CB/SEPTIN2/CBL/MAD2L2/BCAR1	5.18106281402005
NA	NA	hsa04518	Integrin signaling	21/478	154/9376	2.67478128565995	FLT1/FN1/COL4A2/COL4A1/ITGA5/ITGB1/FBN1/VEGFA/LAMB3/LAMA3/THBS1/LAMB1/PDGFD/FLNB/CDH1/PIK3R1/TGFB1/TNC/PIK3CB/ITGA3/ITGA6	4.85690139645898
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	24/478	204/9376	2.30765444253015	TIMP3/CTSL/FN1/IGF2/ITGA5/ITGB1/EZR/VEGFA/THBS1/HSPG2/FGFR1/SDC4/PIK3R1/TGFB1/PIK3CB/ROCK2/EIF4B/CBL/ARHGEF12/RRAS/ARAF/RPS6KB1/SLC9A1/MAPK14	4.37652526643071
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	14/478	89/9376	3.08551549057402	FN1/COL4A2/COL4A1/ITGA5/ITGB1/LAMB3/LAMA3/THBS1/LAMB1/HSPG2/SDC4/TNC/ITGA3/ITGA6	4.58167296366305
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	23/478	203/9376	2.22239627347115	FLT1/FN1/COL4A2/COL4A1/ITGA5/ITGB1/VEGFA/LAMB3/LAMA3/THBS1/LAMB1/PDGFD/FLNB/PIK3R1/MAPK8/TNC/PIK3CB/RAPGEF1/ROCK2/RAP1B/ITGA3/BCAR1/ITGA6	4.08091665546624
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	15/478	110/9376	2.67478128565995	FLT1/SERPINE1/TF/VEGFA/INSR/EPAS1/ALDOB/LDHA/PIK3R1/IFNGR1/PIK3CB/GAPDH/ARNT/PGK1/RPS6KB1	4.09507329956221
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	25/478	238/9376	2.06040575225906	FLT1/IGF2/RASA1/VEGFA/PLA2G5/INSR/PLA2G4A/PDGFD/FGFR1/ETS2/PIK3R1/PLA2G2A/NF1/MAPK8/SHOC2/GNB5/PIK3CB/RALB/RALGAPB/EFNA4/RAP1B/RALGDS/RRAS/TBK1/EXOC2	3.84050524355367
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	13/478	90/9376	2.83328684332868	FOXO1/INSR/PIK3R1/ADIPOR2/ATG13/PIK3CB/ATG101/ATF2/EHMT1/RPS6KB1/AKT1S1/ATG5/SESN2	4.05033292693632
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/478	88/9376	2.67478128565995	SERPINE2/SERPINE1/SERPINC1/KNG1/SERPING1/TFPI/CD55/CD46/C5AR1/F3/CFH/C7	3.65840446031099
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	30/478	333/9376	1.76712277130687	HLA-G/FN1/COL4A2/COL4A1/ITGA5/ITGB1/TCF7L2/VEGFA/FOXO1/LAMB3/LAMA3/THBS1/LAMB1/PTGS2/ISG15/PIK3R1/NOTCH2/DLG1/TNC/PIK3CB/ATP6V1E1/UBE3A/PSMC1/PATJ/ITGA3/RPS6KB1/ITGA6/TBK1/IFNAR2/PPP2R3A	3.30357454954785
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	23/478	232/9376	1.94459673928726	FN1/ITGA5/ITGB1/EZR/KNG1/PDGFD/FGFR1/LPAR1/SSH2/PIK3R1/ARPC1A/WASL/PIK3CB/ROCK2/GSN/ARHGEF12/RRAS/C7/ARAF/ITGA3/SLC9A1/BCAR1/ITGA6	3.3765696429493
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	13/478	101/9376	2.52471104851071	SERPINE1/FN1/COL4A2/COL4A1/VEGFA/FOXO1/PIK3R1/MAPK8/TGFB1/PIK3CB/F3/STAT5B/MAPK14	3.57062844882657
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	24/478	248/9376	1.89823188014577	TNFSF10/ANXA2/TCF7L2/FOS/HSP90B1/RHOB/KLC1/MAPK8/KPNA1/ARPC1A/WASL/PIK3CB/GAPDH/ROCK2/FBXO22/RRAS/DCTN5/VPS39/VPS41/AHNAK/MAPK14/ACBD3/EXOC2/DYNC1LI2	3.32261388429687
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	5/478	19/9376	5.16185862144902	HEXB/GLB1/GUSB/HGSNAT/NAGLU	4.20871186860836
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	12/478	93/9376	2.53097584019436	FN1/COL4A2/COL4A1/ITGB1/LAMB3/LAMA3/LAMB1/PTGS2/PIK3R1/PIK3CB/ITGA3/ITGA6	3.43889584304008
NA	NA	hsa04517	IgSF CAM signaling	27/478	299/9376	1.77125984802899	ITGA5/ITGB1/EZR/RASA1/FOXO1/IL1RAP/PTPRF/FGFR1/TRIO/JAM2/SRGAP1/CDH1/F11R/PIK3R1/MAPK8/ARPC1A/WASL/SRGAP2/PIK3CB/PVR/CABLES1/SPTBN1/NLGN1/SORBS1/RAP1B/MAPK14/BCAR1	3.14136596959444
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	12/478	94/9376	2.50405056529867	CEBPB/TNFAIP3/FOS/HSP90B1/PTGS2/MAPK8/ELAVL1/IL17RE/MAPK14/TBK1/USP25/ANAPC5	3.39671389478086
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	22/478	233/9376	1.85206601181604	FN1/TPM1/COL4A2/COL4A1/FBLN1/ITGA5/ITGB1/FBN1/FMNL2/BGN/SYNE2/THBS1/DSP/HSPG2/SDC4/DMD/SPTBN1/TPM2/SUN1/ITGA3/NID1/ITGA6	3.052532021452
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/478	250/9376	1.80458577405858	HEXB/CTSL/AP3S1/CLTB/PSAP/LAPTM4A/GLB1/ATP6V1E1/AP3D1/SLC29A3/GUSB/ARSA/SNAP29/BLOC1S4/SNAPIN/VPS39/VPS41/HGSNAT/AKT1S1/NAGLU/ENTPD4/CLN3/VAMP7	2.98851546403974
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	15/478	138/9376	2.13207203929416	FOXO1/INSR/PTPRF/PRKAR2B/PHKB/PIK3R1/MAPK8/SREBF1/PIK3CB/RAPGEF1/SORBS1/CBL/PHKA2/ARAF/RPS6KB1	3.10511732274271
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	15/478	138/9376	2.13207203929416	FN1/ITGA5/ITGB1/FOS/PIK3R1/MAPK8/ARPC1A/WASL/PIK3CB/RPS6KA1/ROCK2/ARHGEF12/MAPK14/BCAR1/TBK1	3.10511732274271
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	20/478	212/9376	1.85047761901003	FLT1/ITGB1/VEGFA/INSR/THBS1/PDGFD/FGFR1/LPAR1/CDH1/PIK3R1/PIK3CB/RAPGEF1/RALB/EFNA4/RAP1B/RALGDS/RRAS/ADORA2B/MAPK14/BCAR1	2.90296410143198
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/478	93/9376	2.32006118684483	TCF7L2/INSR/PTPRF/FGFR1/CDH1/WASL/SORBS1/YES1/ROCK2/RAP1B/FER	2.96513688120835
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	9/478	70/9376	2.52193664076509	VEGFA/EPAS1/PIK3R1/TGFB1/PIK3CB/RAPGEF1/ARNT/RAP1B/ARAF	2.96222098706705
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	12/478	110/9376	2.13982502852796	TF/INHBA/FBN1/THBS1/BMP2/LTBP1/NOG/TGFB1/BMPR2/ID4/RPS6KB1/LEMD3	2.78703080841883
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/478	37/9376	3.18082098835237	UGP2/CMAS/GMPPA/GALK1/GALK2/PGM2	3.08052032318338
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	29/478	362/9376	1.57137243117039	FLT1/FN1/COL4A2/COL4A1/IGF2/ITGA5/ITGB1/VEGFA/LAMB3/LAMA3/INSR/THBS1/LAMB1/HSP90B1/PDGFD/FGFR1/LPAR1/PIK3R1/GNB5/TNC/PIK3CB/ATF2/EFNA4/EIF4B/ITGA3/RPS6KB1/ITGA6/IFNAR2/PPP2R3A	2.56961569332922
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	25/478	300/9376	1.63458856345886	FLT1/IGF2/RASA1/VEGFA/DUSP1/INSR/PLA2G4A/IL1RAP/FOS/PDGFD/FGFR1/MAP4K3/NF1/MAPK8/TGFB1/HSPA1B/IL1R1/ATF2/RPS6KA1/EFNA4/RAP1B/SRF/RRAS/ARAF/MAPK14	2.58916072478105
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	6/478	38/9376	3.09711517286941	HEXB/UGP2/GMPPA/GALK1/GALK2/PGM2	3.0022062984179
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	10/478	87/9376	2.25460491511566	TCF7L2/FOS/PIK3R1/MAPK8/TGFB1/PIK3CB/RALB/RALGDS/ARAF/RPS6KB1	2.72480555052571
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	8/478	62/9376	2.53097584019436	FOXO1/INSR/PIK3R1/PIK3CB/HSPA1B/RPS6KB1/AKT1S1/ATG5	2.80317009314356
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/478	52/9376	2.64048921789508	APOA2/APOC3/APOB/APOA1/APOC2/APOH/LRPAP1	2.74933275073695
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	9/478	77/9376	2.29266967342281	VEGFA/PIK3R1/MAPK8/TGFB1/PIK3CB/RALB/RALGDS/ARAF/RPS6KB1	2.63978273871346
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	6/478	41/9376	2.87049698948872	VEGFA/THBS1/CDH1/DAPK1/DAPK3/ARAF	2.78192339362446
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	4/478	20/9376	3.92301255230126	UGP2/CYB5R1/CMAS/GMPPA	3.03287113251428
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	12/478	119/9376	1.9779895221687	CEBPB/TNFAIP3/FOS/PTGS2/PIK3R1/MMP14/MAPK8/PIK3CB/DNM1L/ATF2/ADAM17/MAPK14	2.48843291132778
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	6/478	42/9376	2.80215182307232	SAT1/TF/FTH1/SLC39A14/CP/ATG5	2.71291076104005
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/478	55/9376	2.49646253328262	HEXB/PSAP/GLB1/CERS6/SPTLC1/ACER2/ARSA	2.57970071775679
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/478	109/9376	1.97950174657403	EBI3/IL6ST/IL1RAP/FOS/GATA3/IFNGR1/MAPK8/TGFB1/IL1R1/STAT5B/MAPK14	2.38397813555224
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	11/478	109/9376	1.97950174657403	FOXO1/INSR/PTPRF/PIK3R1/MAPK8/SREBF1/PIK3CB/SLC2A2/RPS6KA1/RPS6KB1/NR1H2	2.38397813555224
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/478	33/9376	2.97197920628883	VTI1A/GOSR1/SNAP29/SEC22B/VAMP7	2.63008335332093
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	15/478	170/9376	1.73074083189761	ITGB1/EZR/CLDN19/JAM2/F11R/DLG1/MAPK8/HSPA4/ARPC1A/RAB8A/ROCK2/PATJ/SYMPK/TJAP1/ARHGEF18	2.22846458426889
NA	NA	hsa04382	Cornified envelope formation	18/478	217/9376	1.6270558972678	PCSK6/COL4A2/COL4A1/KRT8/COL17A1/KRT19/KRT7/LAMB3/LAMA3/DSP/CLDN19/KRT6A/PRSS8/SPTLC1/ELOVL1/KRT18/ITGA6/PPP2R3A	2.16603504940494
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	13/478	142/9376	1.79574518239142	UBE2E2/HERC4/UBE4B/UBE3C/CUL4A/UBE3A/PRPF19/UBA3/CBL/UBE2R2/SAE1/FBXW7/ANAPC5	2.21450487601615
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	13/478	142/9376	1.79574518239142	CTSL/VEGFA/DUSP1/FOS/HSP90B1/SDC4/PIK3R1/MAPK8/BMPR2/PIK3CB/IL1R1/GSTA3/MAPK14	2.21450487601615
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	15/478	174/9376	1.69095368633675	HSP90B1/P4HB/CALR/MAPK8/UBE4B/STT3B/HSPA1B/RRBP1/PDIA4/DNAJB2/TRAM1/UBXN2A/STT3A/HYOU1/UGGT2	2.13223875974398
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	17/478	205/9376	1.62661496071028	HLA-G/TNFAIP3/ISG15/PSMC3/CALR/PIK3R1/MAPK8/PIK3CB/PSMD12/PSMD7/PSMC1/PSMD8/MAPK14/TBK1/IFNAR2/NCOR2/B2M	2.10243573317423
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	20/478	253/9376	1.55059784675939	ITGA5/ITGB1/FOXO1/SEPTIN9/PIK3R1/MAPK8/ARPC1A/WASL/PIK3CB/IL1R1/UBE2V2/RBCK1/SEPTIN2/ROCK2/RPS6KB1/MAPK14/AKT1S1/ATG5/BCAR1/TBK1	2.05768701797841
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	11/478	116/9376	1.86004905497042	ITGB1/EZR/CLDN19/JAM2/F11R/PIK3R1/PIK3CB/ROCK2/RAP1B/MAPK14/BCAR1	2.16023058219988
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/478	36/9376	2.72431427243143	GALNT15/GALNT6/C1GALT1/GALNT2/C1GALT1C1	2.40241273307453
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	10/478	103/9376	1.90437502538896	SERPINE1/FOS/KNG1/CALR/PIK3R1/IFNGR1/MAPK8/TGFB1/PIK3CB/MAPK14	2.13899824831709
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	10/478	103/9376	1.90437502538896	FN1/COL4A2/COL4A1/LAMB3/LAMA3/LAMB1/PIK3R1/TGFB1/PIK3CB/IL1R1	2.13899824831709
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/478	15/9376	3.92301255230126	HEXB/GLB1/ST8SIA1	2.6258418943709
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	12/478	133/9376	1.76978009878252	TNFSF10/FOXO1/INSR/FBXO32/HOMER1/PIK3R1/MAPK8/TGFB1/PIK3CB/PLK3/ARAF/MAPK14	2.07223692839692
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/478	50/9376	2.35380753138075	SAT1/AOC1/CKB/MAOA/AMD1/P4HA1	2.22457784766458
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	11/478	122/9376	1.76857123259483	FOXO1/INSR/PIK3R1/ADIPOR2/ELAVL1/SREBF1/RAB8A/PIK3CB/RPS6KB1/AKT1S1/PPP2R3A	1.98039890927573
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	16/478	200/9376	1.5692050209205	TNFSF10/ITGB1/EZR/FOS/CLDN19/LPAR1/MAPK8/ARPC1A/WASL/BAIAP2L1/MYO1E/IL1R1/GAPDH/ROCK2/ARHGEF12/MAPK14	1.88586414471002
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/478	80/9376	1.96150627615063	VEGFA/PDGFD/NRG2/PIK3R1/NF1/PIK3CB/ARAF/RPS6KB1	2.00171592907505
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	7/478	68/9376	2.01919763721388	ZBTB16/TCF7L2/PIK3R1/PIK3CB/ARAF/RPS6KB1/STAT5B	1.9549608426796
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	13/478	157/9376	1.62417717133491	CEBPB/THBS1/PTGS2/CALR/TGFB1/ARNT/ADAM17/VPS39/VPS41/MFGE8/MAPK14/BCAR1/NR1H2	1.82797051045474
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	13/478	157/9376	1.62417717133491	SERPINE1/TEAD1/TCF7L2/BMP2/WWTR1/CDH1/LIMD1/DLG1/TGFB1/BMPR2/CSNK1D/LATS2/PATJ	1.82797051045474
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/478	29/9376	2.7055258981388	TEAD1/WWTR1/LIMD1/LATS2	2.13193805545395
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	10/478	112/9376	1.7513448894202	ITGB1/LAMB3/LAMA3/LAMB1/IFNGR1/MAPK8/TGFB1/HSPA1B/MAPK14/ITGA6	1.85396896834691
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	9/478	99/9376	1.7831875237733	PLA2G4A/FOS/PDGFD/PIK3R1/MAPK8/PIK3CB/GPCPD1/RALGDS/RPS6KB1	1.81565347550984
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	11/478	130/9376	1.65973607981976	COL4A2/COL4A1/VEGFA/FOS/PIK3R1/MAPK8/TGFB1/GNB5/PIK3CB/ATF2/MAPK14	1.75557081709374
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/478	71/9376	1.93387942719076	FOS/PIK3R1/MAPK8/PIK3CB/SLC2A2/STAT5B/MAPK14	1.83069156151704
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	8/478	86/9376	1.82465700107035	NRG2/PIK3R1/MAPK8/PIK3CB/CBL/ARAF/RPS6KB1/STAT5B	1.7806071164866
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	5/478	45/9376	2.17945141794514	ABCA8/ABCA6/DEFB1/ABCD1/ABCG1	1.8381273826814
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/478	32/9376	2.45188284518828	UGP2/GLB1/GALK1/PGM2	1.90674902908512
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/478	59/9376	1.99475214523793	GPX3/PRDX6/GGT5/PGD/TXNDC12/GSTA3	1.77646325279039
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	9/478	103/9376	1.71393752285006	SMG1/RNGTT/ACIN1/HBS1L/SSU72/TARDBP/SYMPK/UPF3B/PPP2R3A	1.68858169223253
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	5/478	46/9376	2.13207203929416	PSMC3/PSMD12/PSMD7/PSMC1/PSMD8	1.78387961948593
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	6/478	60/9376	1.96150627615063	VEGFA/PLA2G4A/PTGS2/PIK3R1/PIK3CB/MAPK14	1.73167502923601
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	14/478	184/9376	1.49245042750591	ITGB1/RASA1/SEMA5A/SRGAP1/SSH2/PIK3R1/BMPR2/SRGAP2/PIK3CB/ROCK2/EFNA4/NTN4/ARHGEF12/RRAS	1.56357892568982
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/478	47/9376	2.08670880441556	INSR/PIK3R1/MAPK8/PIK3CB/SLC2A2	1.73100353157379
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	11/478	139/9376	1.55227115378827	KRT19/FKBP5/FOS/HSP90B1/PIK3R1/NCOA1/PIK3CB/HSPA1B/ATF2/POMC/KRT18	1.5203643370563
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/478	63/9376	1.86810121538155	PLA2G5/PLA2G4A/PTGS2/GGT5/PLA2G2A/PTGES	1.60231988842829
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	5/478	49/9376	2.00153701648023	GALNT15/GALNT6/C1GALT1/GALNT2/C1GALT1C1	1.62909887113722
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	10/478	125/9376	1.5692050209205	KNG1/PIK3R1/MAPK8/CERS6/SPTLC1/PIK3CB/ROCK2/ACER2/MAPK14/PPP2R3A	1.48485065244802
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	9/478	110/9376	1.60486877139597	PIK3R1/MAPK8/PIK3CB/KIF22/RPS6KA1/MAD2L2/ARAF/MAPK14/ANAPC5	1.47898831727545
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	16/478	224/9376	1.40107591153616	HLA-G/FOS/ETS2/CALR/PIK3R1/DLG1/MAPK8/TGFB1/PIK3CB/IL1R1/NFYB/ATF2/SRF/STAT5B/ANAPC5/B2M	1.40814043155782
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	12/478	158/9376	1.48975160213972	INSR/LPIN1/PIK3R1/PIK3CB/ATP6V1E1/MAPKAP1/RPS6KA1/EIF4B/RPS6KB1/AKT1S1/SESN2/FNIP2	1.43892925636787
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/478	23/9376	2.55848644715299	MME/PRCP/PREP	1.73438243507354
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	16/478	227/9376	1.3825594897978	HLA-G/VEGFA/PTGS2/CALR/PIK3R1/GNB5/PIK3CB/IL1R1/ATF2/ROCK2/ARHGEF12/RPS6KB1/MAPK14/BCAR1/TBK1/B2M	1.35231691462012
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	7/478	82/9376	1.67445657720176	HLA-G/CTSL/CALR/HSPA4/HSPA1B/NFYB/B2M	1.42171639651348
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	14/478	196/9376	1.40107591153616	HLA-G/TCF7L2/IL6ST/VEGFA/FOS/PTGS2/PIK3R1/IFNGR1/MAPK8/GNB5/PIK3CB/MAPK14/TBK1/IFNAR2	1.31518443398348
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	8/478	99/9376	1.58505557668738	FOS/PIK3R1/NOTCH2/MAPK8/PIK3CB/ARAF/RPS6KB1/MAPK14	1.35632675308849
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	8/478	99/9376	1.58505557668738	PLA2G4A/IL1RAP/KNG1/PIK3R1/MAPK8/PIK3CB/IL1R1/MAPK14	1.35632675308849
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	8/478	99/9376	1.58505557668738	TPM1/ITGA5/ITGB1/TGFB1/DMD/TPM2/ITGA3/ITGA6	1.35632675308849
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	9/478	115/9376	1.5350918682918	GCM1/FOS/GATA3/MMP15/FGFR1/MMP14/ATF2/ARAF/WNK1	1.33814049935382
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	15/478	216/9376	1.36215713621571	TNFSF10/APOB/APOA1/FOS/HSP90B1/PIK3R1/MAPK8/HSPA4/PIK3CB/HSPA1B/ROCK2/RAP1B/ABCG1/MAPK14/TBK1	1.24804306628503
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/478	26/9376	2.26327647248149	PLA2G5/PLA2G4A/PLA2G2A	1.49497063524757
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/478	26/9376	2.26327647248149	APOB/APOA1/LMBRD1	1.49497063524757
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	7/478	86/9376	1.59657487593656	ITGA5/ITGB1/TCF7L2/DSP/DMD/ITGA3/ITGA6	1.28813005677632
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/478	168/9376	1.40107591153616	TNFSF10/TNFAIP3/GLUL/PLA2G4A/FTH1/IFNGR1/MAPK8/DNM1L/RBCK1/CHMP3/STAT5B/IFNAR2	1.21577147783092
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	6/478	71/9376	1.65761093759208	JAM2/F11R/MAPK8/ATP6V1E1/ADAM17/MAPK14	1.28912015744107
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/478	71/9376	1.65761093759208	LDHA/FGFR1/PIK3R1/SLC16A3/PIK3CB/SLC2A2	1.28912015744107
Human Diseases	Infectious disease: viral	hsa05162	Measles	10/478	136/9376	1.44228402658134	TNFAIP3/FOS/PIK3R1/MAPK8/CD46/PIK3CB/HSPA1B/STAT5B/TBK1/IFNAR2	1.20417084821203
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/478	27/9376	2.17945141794514	BAAT/ELOVL1/ELOVL5	1.42243603154471
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/478	105/9376	1.49448097230524	CITED2/MAPK8/USP8/RRAS/MFN2/TBK1/CCZ1B/CCZ1	1.18095766513018
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	8/478	105/9376	1.49448097230524	PTGS2/PIK3R1/MAPK8/PIK3CB/PLK3/ARHGEF12/RRAS/MAPK14	1.18095766513018
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	8/478	105/9376	1.49448097230524	TPM1/ITGA5/ITGB1/TGFB1/DMD/TPM2/ITGA3/ITGA6	1.18095766513018
Human Diseases	Cancer: specific types	hsa05218	Melanoma	6/478	73/9376	1.61219693930189	PDGFD/FGFR1/CDH1/PIK3R1/PIK3CB/ARAF	1.21701087598373
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/478	28/9376	2.10161386730424	ST8SIA1/B3GNT2/ST3GAL4	1.3530144781714
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	9/478	122/9376	1.4470128266685	FOXO1/MED17/PIK3R1/NOTCH2/MED13/NCOA1/MED4/PIK3CB/SLC9A1	1.15183040533244
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	9/478	122/9376	1.4470128266685	FOS/IGFBP3/PIK3R1/MAPK8/PIK3CB/ATF2/STAT5B/MAPK14/BCAR1	1.15183040533244
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	8/478	106/9376	1.48038209520802	TCF7L2/FOXO1/HSP90B1/PDGFD/FGFR1/PIK3R1/PIK3CB/ARAF	1.15279813015178
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/478	43/9376	1.82465700107035	APOB/APOA1/PLA2G5/PLA2G2A	1.25617553528017
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	5/478	59/9376	1.66229345436494	TCF7L2/CDH1/PIK3R1/PIK3CB/ARAF	1.18274686802662
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	4/478	44/9376	1.7831875237733	TAF4B/TAF1/GTF2A1/GTF2F2	1.20686340737898
Organismal Systems	Immune system	hsa04611	Platelet activation	9/478	126/9376	1.40107591153616	ITGB1/PLA2G4A/PIK3R1/PIK3CB/ROCK2/RAP1B/ARHGEF12/STIM1/MAPK14	1.05049592289816
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	11/478	160/9376	1.34853556485356	HLA-G/ITGB1/PTPRF/CLDN19/JAM2/CDH1/SDC4/F11R/PVR/NLGN1/ITGA6	1.03059787950189
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/478	16/9376	2.45188284518828	HEXB/ST8SIA1	1.34712230366008
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/478	30/9376	1.96150627615063	PLA2G5/PLA2G4A/PLA2G2A	1.22251233056294
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	7/478	93/9376	1.47640257344671	FOS/GATA3/NOTCH2/IFNGR1/MAPK8/STAT5B/MAPK14	1.07010103388144
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	6/478	77/9376	1.52844644894854	PIK3R1/TGFB1/PIK3CB/CBL/ARAF/STAT5B	1.07914948648486
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	10/478	144/9376	1.36215713621571	INHBA/IL6ST/FGFR1/PIK3R1/BMPR2/ID4/PIK3CB/KAT6A/MAPK14/PCGF3	1.01504145903465
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/478	144/9376	1.36215713621571	PSMC3/PIK3R1/MAPK8/ATG13/PIK3CB/PSMD12/PSMD7/PSMC1/PSMD8/ATG101	1.01504145903465
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	4/478	46/9376	1.70565763143533	FTH1/UGT2B7/GUSB/CP	1.11195067394921
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	6/478	78/9376	1.50885098165433	ITGA5/ITGB1/FOS/SERPING1/MAPK8/MAPK14	1.04591534057872
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	6/478	78/9376	1.50885098165433	ITGB1/FOS/PTGS2/IFNGR1/TGFB1/MAPK14	1.04591534057872
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/478	31/9376	1.89823188014577	ALDOB/PGD/PGM2	1.16100220587491
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/478	31/9376	1.89823188014577	GLUL/GCSH/CS	1.16100220587491
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	11/478	163/9376	1.32371589188079	FOS/HSPG2/PIK3R1/MAPK8/TGFB1/PIK3CB/ATF2/ARAF/STAT5B/MAPK14/TBK1	0.966297092432249
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/478	17/9376	2.30765444253015	GGT5/BAAT	1.25070854333827
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	14/478	217/9376	1.26548792009718	VEGFA/FOS/HSP90B1/UGT2B7/PIK3R1/NOTCH2/KPNA1/PIK3CB/ATF2/RPS6KA1/ARNT/GSTA3/RPS6KB1/STAT5B	0.917073171035843
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/478	32/9376	1.83891213389121	ATG13/ATG101/ATG5	1.1017382718489
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/478	18/9376	2.17945141794514	HEXB/GLB1	1.16085553047224
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	17/478	275/9376	1.21256751616584	MT-ATP8/MT-ND4L/KLC1/PSMC3/PIK3R1/MAPK8/PIK3CB/PSMD12/PSMD7/PSMC1/PSMD8/HSPA1B/ATF2/STIP1/C7/MAPK14/UQCRC1	0.829224401227066
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6/478	82/9376	1.43524849474436	UGT2B7/GUSB/CMPK1/GSTA3/UPP1/NME7	0.917479260270844
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/478	134/9376	1.31742958845938	ADM/PLA2G5/PLA2G4A/KCNMA1/PLA2G2A/ROCK2/ARHGEF12/ADORA2B/ARAF	0.857768727983764
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	22/478	368/9376	1.17263962161179	MT-ATP8/GPX3/MT-ND4L/NRG2/KLC1/PSMC3/ANXA11/ATG13/RAB8A/PSMD12/PSMD7/PSMC1/PSMD8/ATG101/DNAL4/NUP58/DCTN5/TARDBP/MAPK14/TBK1/UQCRC1/TPR	0.783075401532687
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	3/478	34/9376	1.73074083189761	CSNK1D/FBXL3/CRY1	0.989318859391734
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	11/478	170/9376	1.26920994339158	IGF2/TCF7L2/PIK3R1/SMARCA4/TGFB1/SMARCD2/PIK3CB/BRD7/GSTA3/ARAF/RPS6KB1	0.820981664625569
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	23/478	388/9376	1.16274856575939	MT-ATP8/MME/MT-ND4L/INSR/PTGS2/DKK1/SLC39A14/KLC1/PSMC3/PIK3R1/MAPK8/ATG13/PIK3CB/PSMD12/PSMD7/PSMC1/PSMD8/ATG101/GAPDH/ADAM17/ARAF/SLC39A10/UQCRC1	0.758848162254632
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	5/478	67/9376	1.46381065384375	ALDOB/LDHA/GAPDH/PGK1/PGM2	0.883039218295406
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/478	51/9376	1.5384362950201	PLA2G5/PLA2G4A/PLA2G2A/PAFAH1B1	0.893610742149218
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	3/478	35/9376	1.6812910938434	ALDOB/ENOSF1/GMPPA	0.935887040704253
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	4/478	52/9376	1.50885098165433	INSR/PLA2G4A/PTGS2/CYP11A1	0.852794796726528
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	5/478	69/9376	1.42138135952944	PLA2G4A/PIK3R1/MAPK8/PIK3CB/MAPK14	0.814232426882605
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	3/478	36/9376	1.63458856345886	UGP2/UGT2B7/GUSB	0.884144885588228
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/478	157/9376	1.24936705487301	HLA-G/SERPINE1/FOXO1/IGFBP3/PIK3R1/TGFB1/PIK3CB/RRAS/MAPK14/RAD9A	0.730298452940738
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	10/478	157/9376	1.24936705487301	INSR/FOS/PIK3R1/ADIPOR2/MAPK8/TGFB1/SREBF1/PIK3CB/MAPK14/UQCRC1	0.730298452940738
Cellular Processes	Cell motility	hsa04814	Motor proteins	12/478	194/9376	1.21330285122719	TPM1/KIF21A/MYO9A/KLC1/MYO9B/KIF22/MYO1E/TPM2/DNAL4/KIF2A/DCTN5/DYNC1LI2	0.695796543966737
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/478	21/9376	1.86810121538155	XYLT1/B4GALT7	0.923020829051246
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	3/478	37/9376	1.59041049417618	TCF7L2/CDH1/TPR	0.833984786483817
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	9/478	142/9376	1.24320820319406	FOS/PIK3R1/IFNGR1/MAPK8/TGFB1/PIK3CB/IL1R1/MAPK14/IFNAR2	0.6768319353713
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/478	72/9376	1.36215713621571	ISG15/MAPK8/MAPK14/ATG5/TBK1	0.714960140777666
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	3/478	38/9376	1.54855758643471	INSR/PIK3R1/PIK3CB	0.785308819632363
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	6/478	90/9376	1.30767085076708	FOS/PIK3R1/IFNGR1/PIK3CB/RPS6KB1/MAPK14	0.679745988498873
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/478	22/9376	1.7831875237733	AOC1/MAOA	0.85237715988477
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/478	144/9376	1.22594142259414	TCF7L2/FOXO1/LPIN1/ADIPOR2/MAPK8/SREBF1/C5AR1/MAPK14/TBK1	0.633260781888113
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	7/478	109/9376	1.25968292963802	FOS/PIK3R1/MAPK8/PIK3CB/MAPK14/TBK1/IFNAR2	0.632034019947915
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	14/478	238/9376	1.15382722126508	IL6ST/RPS29/FOS/RPS4Y1/ISG15/PIK3R1/MAPK8/C5AR1/PIK3CB/ADAM17/C7/MAPK14/TBK1/IFNAR2	0.557120940367629
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/478	23/9376	1.70565763143533	PDSS2/NUS1	0.785300509589153
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	5/478	75/9376	1.30767085076708	GLUL/ALDOB/GAPDH/PGK1/CS	0.620019784386537
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	5/478	75/9376	1.30767085076708	PIK3R1/TOP2B/ERCC1/PIK3CB/GSTA3	0.620019784386537
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/478	75/9376	1.30767085076708	SERPINE1/THBS1/PERP/IGFBP3/SESN2	0.620019784386537
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	5/478	75/9376	1.30767085076708	ALB/GPX3/HSP90B1/PDIA4/ATF2	0.620019784386537
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	9/478	148/9376	1.19280787063214	TCF7L2/FOS/FGFR1/PIK3R1/NOTCH2/NCOA1/PIK3CB/ARAF/RPS6KB1	0.54796801438902
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/478	24/9376	1.63458856345886	XYLT1/B4GALT7	0.721437974373013
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/478	41/9376	1.43524849474436	GCSH/MAOA/PIPOX	0.64732954737347
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	3/478	41/9376	1.43524849474436	RAD51C/UIMC1/BABAM1	0.64732954737347
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/478	149/9376	1.18480244868159	INSR/PLA2G4A/PDGFD/LPAR1/PIK3R1/PIK3CB/RALB/RALGDS/RRAS	0.527016219299297
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	12/478	205/9376	1.14819879579549	HLA-G/IL6ST/PIK3R1/DLG1/PIK3CB/UBE3A/PSMC1/ATF2/SRF/GSN/GTF2A1/STAT5B	0.497240671593047
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/478	59/9376	1.32983476349195	CMPK1/UPP1/NME7/ENTPD4	0.589030483262857
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	4/478	59/9376	1.32983476349195	INSR/PTGS2/PIK3R1/PIK3CB	0.589030483262857
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/478	95/9376	1.23884606914776	FLT1/CTSL/VEGFA/FOS/TGFB1/ATP6V1E1	0.542295374704383
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/478	78/9376	1.25737581804527	PIK3CB/MTMR3/IP6K2/MTMR4/IPMK	0.529021906398558
Organismal Systems	Digestive system	hsa04978	Mineral absorption	4/478	61/9376	1.28623362370533	TF/FTH1/MT2A/MT1X	0.519813461857164
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	6/478	98/9376	1.20092220988814	PIK3R1/PIK3CB/MTMR3/IP6K2/MTMR4/IPMK	0.463411904125283
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	6/478	98/9376	1.20092220988814	PLA2G4A/PIK3R1/ARPC1A/PIK3CB/GSN/RPS6KB1	0.463411904125283
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	7/478	117/9376	1.17355076350892	MORF4L2/RSF1/SMARCA4/SMARCD2/BRD7/CHD3/SS18	0.437815167723878
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/478	44/9376	1.33739064282997	HEXB/STT3B/STT3A	0.519906674281278
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	15/478	268/9376	1.09785799038281	MT-ATP8/MT-ND4L/DUSP1/SLC39A14/KLC1/PSMC3/MAPK8/PSMD12/PSMD7/PSMC1/PSMD8/MAOA/MFN2/SLC39A10/UQCRC1	0.376708625761546
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	9/478	155/9376	1.13893912808746	HLA-G/CTSL/ITGA5/ITGB1/THBS1/CALR/ATP6V1E1/SEC22B/DYNC1LI2	0.404254434848552
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/478	155/9376	1.13893912808746	TCF7L2/CRH/USP8/ATF2/POMC/ARNT/RAP1B/CYP11A1/PDE8A	0.404254434848552
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	14/478	250/9376	1.09844351464435	HLA-G/CLTB/RAB11FIP1/USP8/ARPC1A/WASL/RAB8A/RAB22A/HSPA1B/CHMP3/CBL/VPS37A/MVB12A/AGAP1	0.365653949317338
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	4/478	63/9376	1.24540081025437	PLOD2/AASS/EHMT1/PIPOX	0.45295478446504
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/478	100/9376	1.17690376569038	ITGA5/MME/CD55/IL1R1/ITGA3/ITGA6	0.412201998921212
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	17/478	308/9376	1.08264956800522	MT-ATP8/GPX3/MT-ND4L/CLTB/KLC1/PSMC3/TAF4B/MAPK8/ATG13/PSMD12/PSMD7/PSMC1/PSMD8/ATG101/DNAL4/DCTN5/UQCRC1	0.341832677105242
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	12/478	214/9376	1.09991006139288	HLA-G/FOS/CALR/PIK3R1/MAPK8/GNB5/CUL4A/PIK3CB/RPS6KB1/MAPK14/TBK1/B2M	0.342668635000761
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	7/478	120/9376	1.1442119944212	PIK3R1/MAPK8/PIK3CB/RAPGEF1/RPS6KA1/RAP1B/MAPK14	0.368496798398854
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	5/478	83/9376	1.18163028683773	SUZ12/BAP1/AEBP2/MGA/PCGF3	0.385214594032921
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	6/478	102/9376	1.15382722126508	PLA2G5/KCNMA1/PLA2G2A/RAB8A/RAP1B/SLC9A1	0.362037136246077
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/478	28/9376	1.40107591153616	ELOVL1/ELOVL5	0.492605922329359
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/478	65/9376	1.20708078532346	ATF2/POMC/CYP11A1/PDE8A	0.388285975106571
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	6/478	103/9376	1.14262501523338	COL4A2/COL4A1/MME/COL17A1/SLC38A2/PRCP	0.337332023978857
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	7/478	122/9376	1.12545442074216	FOS/PIK3R1/DLG1/MAPK8/PIK3CB/MAPK14/PPP2R3A	0.32326190138914
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	10/478	180/9376	1.08972570897257	HLA-G/ITGA5/CALR/PIK3R1/IFNGR1/PIK3CB/SRSF4/TBK1/IFNAR2/B2M	0.281713108432079
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	3/478	48/9376	1.22594142259414	PIK3R1/PIK3CB/SLC2A2	0.363727045287547
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/478	68/9376	1.15382722126508	UGT2B7/CYP26A1/CYP3A5/RDH10	0.295061706514067
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	6/478	107/9376	1.09991006139288	FOXO1/LDHA/PHKB/SLC2A2/ATF2/PHKA2	0.240900698582292
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/478	12/9376	1.63458856345886	CD46	0.509806710012433
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/478	31/9376	1.26548792009718	UGT2B7/GUSB	0.343154220729668
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/478	31/9376	1.26548792009718	SRP54/IMMP1L	0.343154220729668
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	11/478	205/9376	1.05251556281253	MT-ATP8/MT-ND4L/PDK4/INSR/PIK3R1/MAPK8/TGFB1/PIK3CB/GAPDH/MAPK14/UQCRC1	0.176201659276809
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/478	70/9376	1.12086072922893	PTGS2/UGT2B7/CYP3A5/GSTA3	0.235237249071148
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/478	227/9376	1.03691961734835	MT-ATP8/MT-ND4L/VEGFA/FOS/PIK3R1/MAPK8/PIK3CB/ARNT/GSTA3/ARAF/MAPK14/UQCRC1	0.130507867019229
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/478	13/9376	1.50885098165433	PRKDC	0.4255084283996
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/478	73/9376	1.07479795953459	UGT2B7/CYP3A5/MAOA/GSTA3	0.148693866974887
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	4/478	73/9376	1.07479795953459	PIK3R1/PIK3CB/ARAF/STAT5B	0.148693866974887
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	1/478	14/9376	1.40107591153616	B3GNT2	0.348064446884953
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	7/478	133/9376	1.0323717242898	HLA-G/TNFSF10/PIK3R1/IFNGR1/PIK3CB/ARAF/IFNAR2	0.0871442151015746
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/478	133/9376	1.0323717242898	FOS/MAPK8/GNB5/MAOA/ATF2/MAPK14/PPP2R3A	0.0871442151015746
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/478	54/9376	1.08972570897257	LDHA/ENOPH1/AMD1	0.153254281037368
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	8/478	154/9376	1.01896429929903	UGP2/UGT2B7/GUSB/PDXK/CMPK1/PANK2/GMPPA/NME7	0.0549968718524443
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	6/478	115/9376	1.0233945788612	DUSP1/PLA2G4A/PTGS2/GNB5/MAOA/ARAF	0.0585044088586731
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	12/478	235/9376	1.00162022611947	MT-ATP8/MT-ND4L/FGFR1/SMARCA4/SMARCD2/ATF2/RPS6KA1/RPS6KB1/MAPK14/AKT1S1/UQCRC1/NDUFAF2	0.00582996693401338
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	6/478	116/9376	1.01457221180205	ALDOB/GCSH/PGD/GAPDH/PGK1/CS	0.0366017931223265
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/478	116/9376	1.01457221180205	GLUL/PLA2G4A/HOMER1/SLC38A2/GNB5/SHANK2	0.0366017931223265
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/478	76/9376	1.0323717242898	APOA2/APOC3/APOA1/SORBS1	0.0656726499045897
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	3/478	56/9376	1.05080693365212	HSPA1B/HBS1L/SEC22B	0.0883817156750931
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	7/478	137/9376	1.00222948416455	TNFSF10/CTSL/FOS/PIK3R1/MAPK8/PIK3CB/PARP4	0.00609264084752161
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/478	36/9376	1.08972570897257	UGP2/PGM2	0.125010961845075
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	15/478	298/9376	0.987335373901323	IL1RL1/TNFSF10/INHBA/EBI3/IL6ST/IL1RAP/BMP2/INHA/CCL21/IFNGR1/TGFB1/BMPR2/IL1R1/IL17RE/IFNAR2	-0.0514942575894039
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/478	16/9376	1.22594142259414	MAOA	0.209638629388023
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	2/478	37/9376	1.06027366278412	APOA1/KNG1	0.0851396075839638
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	5/478	99/9376	0.99065973542961	KRT19/C5AR1/CFH/DEFB1/KRT18	-0.02165341417558
NA	NA	hsa04519	Cadherin signaling	20/478	404/9376	0.971042710965657	KRT8/TEAD1/TCF7L2/KRT19/KRT7/DSP/WWTR1/KRT6A/FGFR1/CDH1/LIMD1/MAPK8/SHOC2/ARPC1A/MYO1E/LATS2/ROCK2/RRAS/KRT18/MAPK14	-0.137897799793609
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/478	17/9376	1.15382722126508	BAAT	0.147128334196578
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/478	17/9376	1.15382722126508	GLUL	0.147128334196578
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/478	60/9376	0.980753138075314	PLA2G4A/CRH/ARAF	-0.0346636428828791
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	11/478	226/9376	0.954715444144111	FOS/CRH/PIK3R1/MAPK8/PIK3CB/POMC/ROCK2/RAP1B/RRAS/HCAR1/SLC9A1	-0.15971553881339
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/478	18/9376	1.08972570897257	LMBRD1	0.0883110435085304
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	4/478	83/9376	0.945304229470182	BAAT/ABCD1/CRAT/PIPOX	-0.116002729538085
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/478	104/9376	0.943031863533956	PLA2G5/PLA2G4A/LPIN1/PLA2G2A/GPCPD1	-0.135398968896054
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/478	62/9376	0.949115940072884	NOTCH2/ADAM17/NCOR2	-0.0931671625773713
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	9/478	187/9376	0.944040453762334	TNFAIP3/MAPK8/DNM1L/RBCK1/MFN2/MAPK14/ATG5/TBK1/IFNAR2	-0.179148941939926
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/478	19/9376	1.0323717242898	GCSH	0.0327361577165685
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/478	85/9376	0.92306177701206	CMPK1/UPP1/NME7/ENTPD4	-0.165148171642981
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/478	42/9376	0.934050607690775	AOC1/MAOA	-0.0992784369158934
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	7/478	150/9376	0.91536959553696	TCF7L2/CDH1/PIK3R1/TGFB1/PIK3CB/ARAF/RPS6KB1	-0.242169088222397
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/478	108/9376	0.908104757477142	KPNA1/ACIN1/NUP58/UPF3B/TPR	-0.222620564286083
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	23/478	480/9376	0.939888423988843	MT-ATP8/GPX3/MT-ND4L/PTGS2/DKK1/KLC1/PSMC3/MAPK8/ATG13/RAB8A/PSMD12/PSMD7/PSMC1/PSMD8/ATG101/DNAL4/DCTN5/TARDBP/MFN2/ARAF/MAPK14/TBK1/UQCRC1	-0.313353631280449
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	4/478	87/9376	0.901841966046266	TPM1/TPM2/SLC9A1/UQCRC1	-0.213183889624065
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/478	66/9376	0.891593761886649	UGT2B7/CYP3A5/CYP11A1	-0.204835292787103
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	3/478	66/9376	0.891593761886649	GATA3/IFNGR1/TGFB1	-0.204835292787103
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	2/478	44/9376	0.891593761886649	PARP4/SMUG1	-0.167050058816419
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/478	44/9376	0.891593761886649	DCTN5/DYNC1LI2	-0.167050058816419
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/478	21/9376	0.934050607690775	PANK2	-0.0701216190993717
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	3/478	67/9376	0.878286392306251	RPS6KA1/RAP1B/ARAF	-0.231727943511209
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	7/478	154/9376	0.891593761886649	TPM1/TPM2/ATF2/SCN7A/SLC9A1/MAPK14/PPP2R3A	-0.314380399271135
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	15/478	323/9376	0.910916227314533	TIMP3/TPM1/ITGA5/EZR/VEGFA/THBS1/PTGS2/FOXP1/PIK3R1/NOTCH2/BMPR2/TNC/PIK3CB/EFNA4/DICER1	-0.377621738956591
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	3/478	69/9376	0.852828815717664	FOS/MAOA/ATF2	-0.284377910497062
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	8/478	178/9376	0.88157585444972	NOTUM/SFRP1/TCF7L2/DKK1/MAPK8/ROCK2/GPC4/CACYBP	-0.369706379157057
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	3/478	70/9376	0.840645546921698	ADIPOR2/MAPK8/POMC	-0.310159498528032
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	3/478	70/9376	0.840645546921698	HLA-G/CD55/DMD	-0.310159498528032
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/478	23/9376	0.852828815717664	GLUL	-0.163781415895237
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/478	23/9376	0.852828815717664	LARGE1	-0.163781415895237
Genetic Information Processing	Transcription	hsa03040	Spliceosome	11/478	243/9376	0.887924651755428	SNRNP70/HSPA1B/TCERG1/ACIN1/PRPF19/ZMAT2/SLU7/CTNNBL1/SRSF4/SF3A1/SF3B3	-0.410260675507985
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	7/478	158/9376	0.869021767914835	TGFB1/PRKDC/RAD21/MAD2L2/SMC3/ANAPC5/WAPL	-0.384824489131367
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	5/478	115/9376	0.852828815717664	FOS/KCNJ2/PIK3R1/GNB5/PIK3CB	-0.368040954639709
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	4/478	93/9376	0.84365861339812	PLA2G4A/MMP14/MAPK8/MAPK14	-0.351175851613749
NA	NA	hsa03272	Virion - Hepatitis viruses	2/478	48/9376	0.817294281729428	CLDN19/HSPG2	-0.294124956374498
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	8/478	181/9376	0.866964099956078	CEBPB/IFNGR1/MAPK8/TGFB1/NFYB/PLK3/ARHGEF12/MAPK14	-0.418876174518372
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	6/478	138/9376	0.852828815717664	RPS6KA1/MAD2L2/MAPK14/SMC3/ANAPC5/SLK	-0.40367024169996
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/478	49/9376	0.800614806592093	MAOA/ATF2	-0.324319708765061
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	6/478	140/9376	0.840645546921698	SERPINE1/CDH1/GNB5/RRAS/RPS6KB1/SLC9A1	-0.440290835263084
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/478	50/9376	0.784602510460251	THBS1/TGFB1	-0.353941363573287
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	2/478	51/9376	0.76921814751005	ATP6V1E1/PDIA4	-0.383014934887361
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/478	26/9376	0.754425490827164	SLC2A2	-0.290614673807363
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	3/478	76/9376	0.774278793217353	EZR/KCNJ2/SLC9A1	-0.457921538450371
Human Diseases	Cancer: specific types	hsa05214	Glioma	3/478	76/9376	0.774278793217353	PIK3R1/PIK3CB/ARAF	-0.457921538450371
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/478	28/9376	0.700537955768081	ATP6V1E1	-0.367802633512681
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/478	54/9376	0.726483805981714	ERCC1/RAD51C	-0.467174103680404
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	8/478	193/9376	0.813059596331866	CCL21/PIK3R1/GNB5/PIK3CB/ROCK2/RAP1B/STAT5B/BCAR1	-0.608195110385126
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/478	79/9376	0.744875801069859	UGT2B7/CYP3A5/GSTA3	-0.527773001679128
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	7/478	173/9376	0.793673059714127	TNFSF10/PIK3R1/IFNGR1/KPNA1/PIK3CB/TBK1/IFNAR2	-0.63484494265093
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	2/478	56/9376	0.700537955768081	STT3B/STT3A	-0.520932230037901
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	2/478	56/9376	0.700537955768081	CSNK1G1/CSNK1D	-0.520932230037901
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	4/478	105/9376	0.74724048615262	TNFAIP3/PTGS2/CCL21/IL1R1	-0.603659800944534
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/478	30/9376	0.653835425383542	CS	-0.440132811786658
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/478	30/9376	0.653835425383542	PIGG	-0.440132811786658
NA	NA	hsa04081	Hormone signaling	9/478	219/9376	0.806098469650943	IGF2/INSR/CRH/PIK3R1/ADIPOR2/GNB5/PIK3CB/POMC/STAT5B	-0.672945778153506
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/478	57/9376	0.688247816193203	ELOVL1/ELOVL5	-0.547161664635384
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	8/478	201/9376	0.780699015383334	FLT1/ZBTB16/AFF1/CEBPB/FOXO1/ASPSCR1/IGFBP3/SS18	-0.728431905293656
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/478	32/9376	0.612970711297071	LDHA	-0.508283242623556
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	1/478	32/9376	0.612970711297071	MAPK8	-0.508283242623556
Human Diseases	Immune disease	hsa05310	Asthma	1/478	32/9376	0.612970711297071	PRG2	-0.508283242623556
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	6/478	156/9376	0.754425490827164	CLDN19/PIK3R1/PIK3CB/ARAF/TBK1/IFNAR2	-0.716858615522644
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	3/478	86/9376	0.684246375401382	KCNMA1/SLC2A2/ATF2	-0.68177818206478
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/478	33/9376	0.594395841257766	CS	-0.540965514516405
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/478	63/9376	0.622700405127183	CUL4A/ERCC1	-0.696410319498212
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/478	63/9376	0.622700405127183	TCF7L2/BMP2	-0.696410319498212
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	3/478	89/9376	0.66118189083729	PDGFD/LPAR1/CSNK1D	-0.744350151013719
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	3/478	89/9376	0.66118189083729	GLUL/SLC38A2/GNB5	-0.744350151013719
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/478	90/9376	0.653835425383542	UGT2B7/BAAT/SLC9A1	-0.764791270831461
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	3/478	91/9376	0.646650420708998	FOS/PIK3R1/PIK3CB	-0.785032626118818
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	2/478	65/9376	0.603540392661732	PIK3R1/PIK3CB	-0.743379956692996
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/478	37/9376	0.530136831392062	GLUL	-0.66370557131589
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/478	37/9376	0.530136831392062	MAOA	-0.66370557131589
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	6/478	166/9376	0.708978172102636	INSR/KNG1/KCNMA1/ATF2/ROCK2/SRF	-0.876805325398495
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/478	191/9376	0.718876645709654	CRH/GNB5/SLC29A3/MAOA/ATF2/ADORA2B/ARAF	-0.909761209041425
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/478	38/9376	0.516185862144902	NNMT	-0.692622832891329
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/478	168/9376	0.700537955768081	IL6ST/PIK3R1/IFNGR1/PIK3CB/STAT5B/IFNAR2	-0.907751878380463
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/478	39/9376	0.50295032721811	GCSH	-0.720911248818157
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/478	39/9376	0.50295032721811	HLA-G	-0.720911248818157
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/478	69/9376	0.568552543811776	KCNJ2/KCNMA1	-0.833683079186895
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	3/478	98/9376	0.60046110494407	ATF2/POMC/CYP11A1	-0.921506289588695
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	5/478	149/9376	0.658223582600882	MT-ND4L/PTGS2/MAPK8/GNB5/MAPK14	-0.974671692006039
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/478	100/9376	0.588451882845188	TNFSF10/IL6ST/CCL21	-0.958944858417464
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	4/478	128/9376	0.612970711297071	PDE8A/NME7/ENTPD4/PGM2	-1.02182915968419
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	5/478	154/9376	0.636852687061892	PLA2G4A/FOS/PTGS2/KCNJ2/ROCK2	-1.0531349415183
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/478	44/9376	0.445796880943324	HLA-G	-0.854006791914117
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/478	45/9376	0.435890283589028	HLA-G	-0.879142201870562
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	1/478	47/9376	0.417341760883112	LDHA	-0.928108307868471
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/478	79/9376	0.496583867379906	CLTB/ATP6V1E1	-1.04141216129544
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	4/478	138/9376	0.568552543811776	MT-ATP8/MT-ND4L/ATP6V1E1/UQCRC1	-1.18340081157611
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	1/478	50/9376	0.392301255230126	TGFB1	-0.998571166382753
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	1/478	53/9376	0.370095523802005	CLTB	-1.06583057137015
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/478	54/9376	0.363241902990857	HLA-G	-1.08760248839818
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/478	91/9376	0.431100280472665	GNB5/PDE8A	-1.26391785074406
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	8/478	254/9376	0.617797252330906	FLT1/VEGFA/PDGFD/FGFR1/PHKB/ADORA2B/PHKA2/STIM1	-1.43126158518605
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/478	93/9376	0.42182930669906	KCNMA1/SLC9A1	-1.29869377527721
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/478	97/9376	0.404434283742397	FOS/GNB5	-1.36652743502093
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	1/478	65/9376	0.301770196330866	LPIN1	-1.30921292259278
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	2/478	101/9376	0.388417084386263	TCF7L2/POMC	-1.43222898492125
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	1/478	78/9376	0.251475163609055	TOB2	-1.53855183032211
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/478	83/9376	0.236326057367546	TBK1	-1.6196547002511
Genetic Information Processing	Translation	hsa03010	Ribosome	5/478	222/9376	0.441780692826718	RPS29/RPS4Y1/MRPL28/MRPS5/MRPL37	-1.9508742317933
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	4/478	195/9376	0.402360261774488	PIK3R1/C5AR1/PIK3CB/MAPK14	-1.95463272077913
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/478	183/9376	0.321558405926332	SBDS/NOP58/HEATR1	-2.14814091226035
NA	NA	hsa04082	Neuroactive ligand signaling	3/478	199/9376	0.295704463741301	GNB5/POMC/ADORA2B	-2.3274721555253
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	1/478	143/9376	0.137168271059484	C7	-2.40977277655079
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	7/478	370/9376	0.371095781974443	ADM/KNG1/CRH/LPAR1/C5AR1/POMC/ADORA2B	-2.86070308319457
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/478	449/9376	0.0436861086002367	NCALD	-4.81309299963294