category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	22/383	105/9376	5.12923038667164	NFKB1/NFKBIA/PAK1/RELB/NFKB2/IRF1/CYLD/NFATC1/AKT3/MAPKAPK2/ITPR1/MALT1/MAPK1/STAT1/PLK3/MAPK8/BCL10/PTGS2/ITPR3/PLCG2/KSR1/PTPN11	8.78078214174673
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	22/383	142/9376	3.79274077887692	NFKB1/NFKBIA/RELB/NFKB2/CYLD/FYN/NFATC1/AKT3/TGFB1/ITPR1/MAPK1/STAT1/MAPK8/JUND/ITPR3/MAP2K1/SOCS1/ATP2A2/PLCG2/ATP2A3/CAMK4/SQSTM1	6.92010353328715
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	26/383	205/9376	3.10483347131121	NFKB1/TNFAIP3/CD44/RUNX3/NFKBIA/HLA-DQA2/RELB/NFKB2/CDKN1A/BCL2/AKT3/CD58/STAT3/HLA-DRB5/CCND3/TAPBP/STAT1/TRAF3/HLA-F/USP7/HLA-B/CD40/MAPK8/HLA-DQB1/PLCG2/SIN3A	6.28809441002381
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	14/383	66/9376	5.19281588733286	NFKB1/HLA-DQA2/SMAD3/NFATC1/TGFB1/STAT3/STAT4/HLA-DRB5/IL4R/STAT1/IL2RG/IL21R/IL18R1/HLA-DQB1	7.05400313062845
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	29/383	253/9376	2.80605579004943	NFKB1/CD44/FNBP1/NFKBIA/BCL2/AKT3/ITPR1/MALT1/TNIP1/CDC42/MAPK1/DIAPH1/FOXO1/UBE2D3/SEPTIN6/PRKCE/MAPK8/UBE2N/ROCK1/BCL10/CYTH1/UBE2D1/RPS6KA5/ITPR3/CAST/CUL1/PLCG2/CXCL8/SQSTM1	6.00973487899007
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	17/383	101/9376	4.12046635472947	NFKB1/BCL2/SMAD3/NFATC1/AKT3/TGFB1/STAT3/CDC42/MAPK1/DIAPH1/FOXO1/STAT1/PRKCE/MAPK8/VEGFA/PLCG2/CXCL8	6.50662774220819
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	14/383	70/9376	4.89608355091384	PAK1/CDKN1A/BRAF/AKT3/TGFB1/CDC42/MAPK1/RAPGEF1/CREBBP/VEGFA/MAP2K1/EP300/PAK2/PTPN11	6.75193862755539
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	17/383	105/9376	3.96349620788263	NFKB1/TNFAIP3/BIRC3/NFKBIA/RELB/NFKB2/CYLD/BCL2/MALT1/TRAF3/TRAF1/CD40/BCL10/PTGS2/BIRC2/PLCG2/CXCL8	6.30185582846222
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	15/383	83/9376	4.42417188335588	JARID2/ASXL1/EZH2/UBE2D3/YY1/USP7/BCOR/CREBBP/SFMBT1/UBE2D1/KDM2B/EP300/LCOR/RYBP/FOXK2	6.46620342011033
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	24/383	196/9376	2.99760217402888	NFKB1/NFKBIA/CDKN1A/NFATC1/AKT3/MAPKAPK2/STAT3/ITPR1/MAPK1/STAT1/TRAF3/HLA-F/TCF7/HLA-B/MAPK8/CREBBP/GNB1/VEGFA/PTGS2/ITPR3/MAP2K1/EP300/PLCG2/CXCL8	5.83241509837458
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	18/383	120/9376	3.67206266318538	NFKB1/NFKBIA/BRAF/BCL2/AKT3/MAPKAPK2/CDC42/MAPK1/RAPGEF1/MAPK8/IRAK2/RPS6KA5/MAP2K1/PLCG2/ARHGDIB/CAMK4/ZNF274/PTPN11	6.07936637674957
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	31/383	300/9376	2.52964316797215	NFKB1/PAK1/RELB/NFKB2/BRAF/NFATC1/AKT3/MAPKAPK2/NR4A1/TGFB1/CDC42/MAPK1/DUSP10/DUSP2/PPM1A/FLNA/DUSP16/MAPK8/STK4/PTPN7/VEGFA/KIT/RPS6KA5/JUND/RASGRP1/MAP2K1/DDIT3/RASA2/PAK2/DUSP5/AREG	5.55694685748897
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	17/383	109/9376	3.8180468057585	NFKB1/NFKBIA/HLA-DQA2/SMAD3/NFATC1/TGFB1/HSP90AB1/STAT3/HLA-DRB5/MAPK1/IL4R/STAT1/IL2RG/IL21R/MAPK8/HLA-DQB1/IRF4	6.1069532879658
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	18/383	122/9376	3.61186491460857	NFKB1/NFKBIA/PAK1/FYN/NFATC1/AKT3/PPP2R5C/MALT1/CDC42/MAPK1/VAV1/MAPK8/BCL10/RASGRP1/MAP2K1/PPP2R2D/PAK2/PTPN11	5.99236981561622
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	14/383	77/9376	4.45098504628531	NFKB1/CDKN1A/BRAF/SMAD3/AKT3/TGFB1/STAT3/CDC42/MAPK1/RALGDS/STAT1/MAPK8/VEGFA/MAP2K1	6.27484560975793
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	20/383	157/9376	3.11852455472219	NFKB1/CDKN1A/SMAD3/NFATC1/AKT3/MAPKAPK2/TGFB1/RASSF5/ITPR1/CCND3/MAPK1/FOXO1/HLA-F/ZFP36L2/HLA-B/HIPK2/ITPR3/MAP2K1/CXCL8/SQSTM1	5.5242604926516
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	21/383	173/9376	2.97161140373383	NFKB1/NFKBIA/HLA-DQA2/AKT3/HLA-DRB5/CCND3/MAPK1/KPNA1/TPSAB1/TPSB2/NUP98/STAT1/TRAF3/RAB11A/NXF1/CREBBP/DNAJB1/HLA-DQB1/MAP2K1/EP300/CXCL8	5.40147525005421
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	23/383	205/9376	2.74658345539069	NFKB1/REL/NFKBIA/NFKB2/CDKN1A/CHD4/MAPKAPK2/STAT3/CCND3/CDC42/MAPK1/HDAC4/TRAF3/HLA-F/USP7/TRAF1/HLA-B/CREBBP/GTF2B/EP300/YWHAZ/RASA2/UBR4	5.21783875645068
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	20/383	163/9376	3.00373223982444	NFKB1/NFKBIA/CDKN1A/BRAF/BCL2/SMAD3/NFATC1/AKT3/TGFB1/STAT3/STAT4/MAPK1/STAT1/TRAF3/MAPK8/CREBBP/MAP2K1/EP300/YWHAZ/CXCL8	5.32556489392293
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	16/383	112/9376	3.49720253636703	NFKB1/BIRC3/NFKBIA/HLA-DQA2/BCL2/AKT3/TGFB1/STAT3/HLA-DRB5/MAPK1/STAT1/CD40/MAPK8/BIRC2/HLA-DQB1/SOCS1	5.48651074386206
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/383	181/9376	2.84026946323731	NFKB1/HLA-DQA2/BCL2/AKT3/TGFB1/HLA-DRB5/MALT1/MAPK1/STAT1/RAB5A/HSPD1/PLK3/MAPK8/CREBBP/ITGAX/BCL10/IRAK2/HLA-DQB1/CEBPG/EP300/KSR1	5.15914303636012
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	16/383	119/9376	3.29148474011014	NFKB1/TNFAIP3/BIRC3/NFKBIA/IRF1/CYLD/AKT3/MAPK1/TRAF3/TRAF1/MAPK8/IL18R1/PTGS2/BIRC2/RPS6KA5/MAP2K1	5.19144248323681
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	23/383	224/9376	2.5136143230138	NFKB1/NFKBIA/HLA-DQA2/RELB/NFKB2/CDKN1A/SMAD3/NFATC1/AKT3/TGFB1/HLA-DRB5/CCND3/MAPK1/HLA-F/IL2RG/HLA-B/CD40/MAPK8/CREBBP/HLA-DQB1/MAP2K1/EP300/TCF3	4.73166468912887
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	17/383	142/9376	2.93075423822307	BIRC3/SMURF1/UBE2G1/UBE2D3/UBE2R2/UBE2H/UBE2S/HUWE1/SIAH1/UBE2N/UBR5/UBE2D1/BIRC2/SOCS1/PIAS1/CUL1/HERC1	4.78419598657118
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	12/383	78/9376	3.76621811608757	BTG1/TENT4A/CNOT6L/DCP1A/DDX6/CNOT1/HSPD1/BTG2/PFKP/PABPC1/BTG3/PABPC4	5.06257744729651
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	18/383	157/9376	2.80667209924997	NFATC1/MAPKAPK2/TGFB1/ATP11B/MAPK1/DUSP2/RAB5A/XKR6/DUSP16/PPARD/SLC16A1/PTGS2/MAP2K1/ATP2A2/ATP2A3/GPR132/DUSP5/PTPN11	4.71107463862808
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	14/383	103/9376	3.32743542295115	PPP2R5C/SMG1/GSPT1/DDX39B/MSI2/FUS/NXF1/PABPC1/PAPOLA/WDR33/RBM8A/PCF11/PABPC4/PPP2R2D	4.90138537775524
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	24/383	248/9376	2.36907268592605	NFKB1/BIRC3/NFKBIA/PAK1/RHOH/BCL2/AKT3/HSP90AB1/CDC42/MAPK1/KPNA1/RAB5A/TUBB4B/CYFIP2/FLNA/TCF7/MAPK8/ACBD3/KPNA4/CYTH1/BIRC2/MAP2K1/ABI1/CXCL8	4.50917675174248
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	13/383	93/9376	3.42199387967096	NFKB1/RUNX3/NFKBIA/HLA-DQA2/NFATC1/STAT4/HLA-DRB5/MAPK1/IL4R/STAT1/IL2RG/MAPK8/HLA-DQB1	4.8439881147409
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	14/383	106/9376	3.23326272230159	NFKB1/NFKBIA/CDKN1A/BRAF/BCL2/AKT3/HSP90AB1/MAPK1/FOXO1/ZEB1/TCF7/CREBBP/MAP2K1/EP300	4.77183711505466
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	16/383	133/9376	2.94501266220381	CDKN1A/BRAF/SMAD3/AKT3/TGFB1/STAT3/MAPK1/FOXO1/USP7/PLK3/MAPK8/CREBBP/STK4/MAP2K1/EP300/HOMER1	4.66202400515205
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	15/383	122/9376	3.00988742884047	AKT3/MAPK1/FOXO1/STAT1/MED13/PFKP/CREBBP/ATP1B3/MAP2K1/MED4/ATP2A2/EP300/PLCG2/ATP2A3/SIN3A	4.61126021258076
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	19/383	180/9376	2.58404409631564	NFKB1/BIRC3/NFKBIA/HLA-DQA2/BCL2/AKT3/HLA-DRB5/TAPBP/ZC3HAV1/STAT1/TRAF3/HLA-F/PILRB/NXF1/HLA-B/SRSF7/BIRC2/HLA-DQB1/PTPN11	4.42829726736276
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	16/383	137/9376	2.85902689104458	NFKB1/BIRC3/NFKBIA/BCL2/AKT3/ITPR1/MAPK1/EIF2AK3/LMNA/SPTAN1/TRAF1/MAPK8/BIRC2/ITPR3/MAP2K1/DDIT3	4.52341256887276
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	14/383	110/9376	3.11568953239972	SKI/SMAD3/SMURF1/SKIL/TGFB1/SMAD7/TGIF2/EMP3/MAPK1/CREBBP/ROCK1/CUL1/EP300/SIN3A	4.60611588829898
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	21/383	214/9376	2.40228398526146	NFKB1/NFKBIA/PAK1/AP1S3/BCL2/NFATC1/AKT3/ITPR1/MAPK1/TAPBP/HLA-F/HLA-B/MAPK8/GNB1/AP1G1/ITPR3/MAP2K1/CUL1/DCAF1/PLCG2/PAK2	4.28233309911914
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	21/383	216/9376	2.38004061502756	NFKB1/NFKBIA/NFE2L2/BCL2/NFATC1/AKT3/HSP90AB1/STAT3/ITPR1/CDC42/MAPK1/EIF2AK3/VAV1/TRAF3/HSPD1/CD40/MAPK8/HSPA4/ABCG1/DDIT3/CXCL8	4.23451558127905
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	12/383	87/9376	3.37660934545782	CDKN1A/BRAF/BCL2/SMAD3/AKT3/TGFB1/MAPK1/RALGDS/TCF7/MAPK8/MAP2K1/AREG	4.59584818213148
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	19/383	203/9376	2.29127062727495	BIRC3/PAK1/FYN/BRAF/BCL2/AKT3/CCND3/CDC42/MAPK1/DIAPH1/VAV1/RAPGEF1/FLNA/MAPK8/ROCK1/VEGFA/BIRC2/MAP2K1/PAK2	3.83833010988054
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	19/383	204/9376	2.2800389085138	CD44/EZR/PAK1/CDKN1A/BRAF/AKT3/TGFB1/STAT3/ITPR1/CDC42/MAPK1/VAV1/FLNA/ROCK1/VEGFA/ITPR3/MAP2K1/PLCG2/PTPN11	3.81451177607917
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	26/383	323/9376	1.97055994309226	NFKB1/CD44/EZR/CDKN1A/BCL2/STAT3/EZH2/GLS/SLC7A1/MAPK1/ZEB1/HDAC4/ABCC1/PRKCE/CREBBP/ROCK1/VEGFA/PTGS2/RPS6KA5/MAP2K1/DDIT4/SOCS1/FOXP1/EP300/ABCB1/PLCG2	3.66319546294419
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	21/383	238/9376	2.16003686069728	NFKB1/REL/PAK1/AKT3/RASSF5/CDC42/MAPK1/RALGDS/RAB5A/MAPK8/STK4/GNB1/VEGFA/KIT/RASGRP1/MAP2K1/PLCG2/KSR1/RASA2/PAK2/PTPN11	3.74082523779437
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	13/383	117/9376	2.72004641717435	CHD4/BAZ1A/ARID2/GATAD2A/SRCAP/YY1/INO80D/SMARCA2/CHRAC1/GATAD2B/SS18/EPC1/CHD3	3.86352551087605
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/383	90/9376	2.99205105889179	NFKB1/NFKBIA/NFATC1/AKT3/STAT3/MAPK1/STAT1/BATF/RASGRP1/MAP2K1/PTPN11	3.91868278749381
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	10/383	77/9376	3.17927503306093	NFKB1/NFKBIA/CDKN1A/BRAF/SMAD3/AKT3/TGFB1/MAPK1/MAP2K1/PTPN11	3.96252495743992
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	10/383	78/9376	3.13851509673964	NFKB1/NFKBIA/HLA-DQA2/TGFB1/HLA-DRB5/MAPK1/STAT1/MARCKSL1/PTGS2/HLA-DQB1	3.91379054185708
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/383	41/9376	4.17958351907279	CDKN1A/BRAF/MAPK1/VEGFA/RPS6KA5/MAP2K1/CXCL8	4.21053937382679
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	18/383	201/9376	2.19227621682709	NFKB1/REL/BIRC3/CDKN1A/FOXO1/ZEB1/DOT1L/FUS/TRAF1/KDM6A/CD40/ETV6/BIRC2/SS18/DDIT3/SIN3A/TCF3/CXCL8	3.52618100469749
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/383	94/9376	2.86472973723682	NFKB1/TNFAIP3/NFKBIA/HSP90AB1/MAPK1/MAPK6/TRAF3/MAPK8/PTGS2/JUND/CXCL8	3.74965896384443
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	9/383	68/9376	3.24005529104592	NFKB1/BRAF/AKT3/STAT3/MAPK1/TCF7/PPARD/KIT/MAP2K1	3.82576011914235
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	12/383	110/9376	2.67059102777118	NFKB1/CDKN1A/BCL2/AKT3/STAT3/MAPK1/PFKP/CREBBP/VEGFA/MAP2K1/EP300/PLCG2	3.63708179202391
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	13/383	125/9376	2.5459634464752	NFKB1/FYN/BCL2/AKT3/PPP2R5C/MAPK1/MS4A2/ABCC1/PRKCE/MAPK8/ROCK1/MAP2K1/PPP2R2D	3.59081156730446
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	9/383	70/9376	3.14748228273032	HLA-DQA2/FYN/HLA-DRB5/HLA-F/EIF4G2/HLA-B/CD40/HLA-DQB1/CD55	3.72160103531578
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	9/383	71/9376	3.10315154635384	NFKB1/IRF1/AKT3/STAT3/MAPK1/STAT1/MAPK8/MAP2K1/SOCS1	3.67091460482963
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	17/383	193/9376	2.15630622708641	NFKB1/NFKBIA/PAK1/BRAF/AKT3/STAT3/CDC42/MAPK1/GRK5/VAV1/CCR7/STAT1/ROCK1/GNB1/MAP2K1/PLCG2/CXCL8	3.34959234439376
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	12/383	115/9376	2.55447837438983	CDKN1A/BRAF/BCL2/MEF2D/ITPR1/MAPK1/PDE4A/NR4A2/JUND/ITPR3/MAP2K1/STK39	3.46128524590731
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	10/383	86/9376	2.84656020401967	PAK1/CDKN1A/BRAF/AKT3/MAPK1/MAPK8/MAP2K1/PLCG2/PAK2/AREG	3.55007533167203
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	9/383	73/9376	3.0181336957688	CDKN1A/BRAF/AKT3/STAT3/RASSF5/MAPK1/STK4/MAP2K1/PLCG2	3.57217380733512
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	8/383	60/9376	3.26405570060923	AKT3/MAPKAPK2/CDC42/MAPK1/VEGFA/PTGS2/MAP2K1/PLCG2	3.63061937499547
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	20/383	250/9376	1.95843342036554	SMAD3/SMURF1/EHD1/SMAP2/CDC42/VPS37B/GRK5/CHMP1B/RAB5A/HLA-F/IL2RG/RAB11A/HLA-B/ACAP1/RAB22A/CYTH1/ARFGEF1/IST1/CAPZA1/CHMP4B	3.16974590653699
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	17/383	200/9376	2.08083550913838	NFKB1/EZR/NFKBIA/PAK1/FYN/CDC42/MAPK1/TUBB4B/CYFIP2/MAPK8/MYO1D/ROCK1/CYTH1/ABI1/PAK2/CXCL8/PTPN11	3.18845746814219
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/383	37/9376	3.96979747371392	CDKN1A/BRAF/MAPK1/TCF7/CCDC6/MAP2K1	3.7351688260233
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	15/383	168/9376	2.18575158522939	CDKN1A/BCL2/AKT3/STAT3/STAT4/CCND3/IL4R/STAT1/IL2RG/IL21R/CREBBP/SOCS1/PIAS1/EP300/PTPN11	3.20035701006492
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	10/383	91/9376	2.69015579720541	NFKB1/NFKBIA/NFATC1/AKT3/MALT1/MAPK1/VAV1/BCL10/MAP2K1/PLCG2	3.34340671192391
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	12/383	122/9376	2.40790994307238	AKT3/STAT3/ITPR1/MAPK1/STAT1/MAPK8/CREBBP/ITPR3/MAP2K1/SOCS1/EP300/PLCG2	3.23015060954531
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	10/383	93/9376	2.63230298436228	FYN/SMAD3/SMURF1/CDC42/MAPK1/TCF7/CREBBP/ROCK1/SORBS1/EP300	3.26460620824573
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/383	93/9376	2.63230298436228	NFKB1/BIRC3/NFKBIA/CDKN1A/BCL2/AKT3/TRAF3/TRAF1/PTGS2/BIRC2	3.26460620824573
Human Diseases	Immune disease	hsa05330	Allograft rejection	6/383	39/9376	3.76621811608757	HLA-DQA2/HLA-DRB5/HLA-F/HLA-B/CD40/HLA-DQB1	3.57229876791627
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	18/383	226/9376	1.94976778576215	NFKB1/NFKBIA/PAK1/BRAF/NFATC1/AKT3/MAPK1/VAV1/MAPK8/CREBBP/ATP1B3/PDE4A/ROCK1/MAP2K1/ATP2A2/EP300/ATP2A3/CAMK4	2.98259191388539
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	18/383	227/9376	1.94117850036231	NFKB1/NFKBIA/CDKN1A/NFATC1/AKT3/STAT3/ITPR1/MAPK1/TAPBP/HLA-F/HLA-B/ROCK1/GNB1/VEGFA/PTGS2/ITPR3/MAP2K1/CXCL8	2.9623122954537
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	8/383	67/9376	2.92303495576946	BRAF/ITPR1/MAPK1/CREBBP/ITPR3/MAP2K1/EP300/CAMK4	3.25991137477834
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	10/383	98/9376	2.49800181169073	NR4A1/ITPR1/CAMK1D/PRKCE/ATP1B3/NR4A2/PRKD2/ITPR3/PRKD3/CAMK4	3.07631583402131
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/383	69/9376	2.83830930487759	FYN/AKT3/MAPK1/VAV1/MS4A2/MAPK8/MAP2K1/PLCG2	3.16279469982413
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	8/383	71/9376	2.7583569300923	NFKB1/NFKBIA/PAK1/CDC42/MAPK8/PLCG2/CXCL8/PTPN11	3.06909796698657
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	8/383	71/9376	2.7583569300923	SLC7A5/AKT3/GLS/MAPK1/SLC16A3/PFKP/KIT/MAP2K1	3.06909796698657
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	6/383	44/9376	3.33823878471398	HLA-DQA2/HLA-DRB5/HSPD1/HLA-F/HLA-B/HLA-DQB1	3.20819355189952
Human Diseases	Immune disease	hsa05310	Asthma	5/383	32/9376	3.82506527415144	HLA-DQA2/HLA-DRB5/MS4A2/CD40/HLA-DQB1	3.30346560630483
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	23/383	333/9376	1.69083966473	NFKB1/IRF1/CDKN1A/CHD4/AKT3/PPP2R5C/CCND3/CDC42/MAPK1/FOXO1/STAT1/TRAF3/HLA-F/TCF7/HLA-B/CREBBP/NFX1/VEGFA/PTGS2/MAP2K1/EP300/UBR4/PPP2R2D	2.64896270914551
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	15/383	187/9376	1.96366987336117	NFKB1/TNFAIP3/BIRC3/NFKBIA/BCL2/HSP90AB1/ITPR1/MAPK1/STAT1/TRAF3/MAPK8/BIRC2/ITPR3/GBP4/CXCL8	2.7469306049919
NA	NA	hsa04517	IgSF CAM signaling	21/383	299/9376	1.71936044430085	EZR/PAK1/FYN/AKT3/CDC42/MAPK1/FOXO1/VAV1/TUBB4B/MBP/SPTAN1/PPFIA1/MAPK8/ITGAX/SORBS1/CD96/MAP2K1/PLCG2/CD48/PAK2/PTPN11	2.60881755589476
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/383	156/9376	2.04003481288077	NFKB1/NFKBIA/CDKN1A/BRAF/AKT3/STAT3/MAPK1/STAT1/TRAF3/MAP2K1/PIAS1/YWHAZ/PPP2R2D	2.70319542483985
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	12/383	140/9376	2.09832152182022	SMAD3/AKT3/MEF2D/ITPR1/MAPK1/HDAC4/PRKCE/GNB1/ITPR3/MAP2K1/NRF1/CAMK4	2.70199336329407
Human Diseases	Cancer: specific types	hsa05214	Glioma	8/383	76/9376	2.57688607942834	CDKN1A/BRAF/AKT3/MAPK1/CAMK1D/MAP2K1/PLCG2/CAMK4	2.84838289848757
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	13/383	158/9376	2.01421158740126	CDKN1A/SMAD3/TGFB1/PPP2R5C/CCND3/CDC14A/NIPBL/DBF4/CREBBP/STAG2/CUL1/EP300/YWHAZ	2.65320916080917
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	10/383	109/9376	2.24590988574029	NFKB1/NFKBIA/AKT3/MAPK1/STAT1/TRAF3/CD40/MAPK8/MAP2K1/CXCL8	2.69999542153908
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	8/383	80/9376	2.44804177545692	BRAF/BCL2/AKT3/STAT3/MAPK1/VEGFA/MAP2K1/PLCG2	2.68417455890504
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	13/383	166/9376	1.91714114945421	RGS2/NFATC1/AKT3/MEF2D/ITPR1/MAPK1/PRKCE/ATP1B3/ROCK1/ITPR3/MAP2K1/ATP2A2/ATP2A3	2.46032872307937
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	8/383	82/9376	2.38833343947016	HLA-DQA2/HSP90AB1/HLA-DRB5/TAPBP/HLA-F/HLA-B/HSPA4/HLA-DQB1	2.60574615033172
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	9/383	98/9376	2.24820163052166	PAK1/AKT3/CDC42/MAPK1/VAV1/MARCKSL1/PRKCE/MAP2K1/PLCG2	2.56332296133281
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	12/383	149/9376	1.97157726882436	FYN/AKT3/MAPK1/RALGDS/MS4A2/CYTH1/KIT/DGKA/MAP2K1/PLCG2/CXCL8/PTPN11	2.46702157635254
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	13/383	168/9376	1.89431804053214	TNFAIP3/BIRC3/CYLD/BCL2/HSP90AB1/STAT3/STAT4/STAT1/CHMP1B/MAPK8/BIRC2/CHMP4B/SQSTM1	2.41377455944185
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/383	133/9376	2.02469620526512	PAK1/FYN/BRAF/NFATC1/MAPK1/VAV1/HLA-B/MAP2K1/PLCG2/CD48/PTPN11	2.45610653327131
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	6/383	54/9376	2.72004641717435	HLA-DQA2/HLA-DRB5/HLA-F/HLA-B/CD40/HLA-DQB1	2.61586439128806
Human Diseases	Infectious disease: viral	hsa05162	Measles	11/383	136/9376	1.98003378897251	NFKB1/TNFAIP3/NFKBIA/BCL2/AKT3/STAT3/CCND3/STAT1/TRAF3/IL2RG/MAPK8	2.3757856035526
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	7/383	70/9376	2.44804177545692	NFKB1/NFKBIA/AKT3/STAT3/MAPK8/ACSL3/PTPN11	2.50946599841993
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	11/383	138/9376	1.95133764710334	NFKB1/NFKBIA/NFATC1/AKT3/CDC42/MAPK1/VAV1/MAPK8/ROCK1/MAP2K1/CXCL8	2.32336785333731
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	13/383	174/9376	1.82899672878965	NFE2L2/BCL2/HSP90AB1/UBE2G1/EIF2AK3/UBE2D3/DNAJA1/PPP1R15A/MAPK8/DNAJB1/UBE2D1/CUL1/DDIT3	2.27781818060139
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	15/383	212/9376	1.73210502980442	SIPA1L1/BRAF/AKT3/RASSF5/CDC42/MAPK1/VAV1/RALGDS/RAPGEF1/SKAP1/PRKD2/VEGFA/KIT/MAP2K1/PRKD3	2.22500765403382
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	12/383	157/9376	1.87111473283331	BIRC3/SMAD3/TGFB1/TP53BP2/SMAD7/CCND3/CSNK1D/TCF7/BIRC2/YWHAZ/PPP2R2D/AREG	2.2715170765575
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/383	72/9376	2.38004061502756	NFKB1/NFKBIA/CYLD/ZNFX1/TRAF3/MAPK8/CXCL8	2.42580559750095
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	7/383	73/9376	2.34743731893129	NUP153/ELL2/AFF4/RANBP2/CREBBP/EP300/CHMP4B	2.38501557543174
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/383	178/9376	1.78789567870449	SMAD3/NFATC1/CCDC88C/CCND3/TCF7/MAPK8/SIAH1/CREBBP/PPARD/TBL1X/CUL1/EP300/CACYBP	2.19010403623318
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	9/383	108/9376	2.04003481288077	NUP153/KPNA1/NUP98/DDX39B/KPNB1/NXF1/RANBP2/KPNA4/RBM8A	2.24336257395314
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	6/383	59/9376	2.48953400893924	CDKN1A/BRAF/AKT3/MAPK1/TCF7/MAP2K1	2.36848757076569
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	5/383	45/9376	2.72004641717435	HLA-DQA2/HLA-DRB5/HLA-F/HLA-B/HLA-DQB1	2.38679466036497
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/383	32/9376	3.06005221932115	BIRC3/BCL2/MAPK8/BIRC2	2.40890421753651
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/383	63/9376	2.33146835757802	KMT2E/EZH2/DOT1L/SETD2/ASH1L/KMT2C	2.18821026798533
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	9/383	115/9376	1.91585878079237	FYN/BCL2/AKT3/ITPR1/MAPK1/GNB1/ITPR3/MAP2K1/CAMK4	2.03930047372683
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	12/383	170/9376	1.72802948855783	NFE2L2/CDKN1A/BRAF/SMAD3/AKT3/TGFB1/ARID2/MAPK1/TCF7/SMARCA2/MAP2K1/PLCG2	1.97683615076717
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	8/383	98/9376	1.99840144935259	INPP5A/ITPR1/ITPKB/PIP4K2A/SYNJ2/DGKA/ITPR3/PLCG2	2.0503300886443
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	4/383	34/9376	2.88004914759638	PER1/BHLHE40/CSNK1D/CUL1	2.26632118308119
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	11/383	154/9376	1.74860126818351	RGS2/CDKN1A/NFATC1/ITPR1/MAPK1/CAMK1D/ROCK1/PTGS2/ITPR3/MAP2K1/CAMK4	1.93299659253002
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	5/383	50/9376	2.44804177545692	HLA-DQA2/TGFB1/HLA-DRB5/CD40/HLA-DQB1	2.1186104805348
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	10/383	138/9376	1.77394331554849	INPP5A/BRAF/AKT3/MAPK1/FOXO1/RAPGEF1/MAPK8/SORBS1/MAP2K1/SOCS1	1.89013335604423
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	8/383	103/9376	1.9013916702578	NFKB1/NFKBIA/AKT3/TGFB1/MAPK1/MAPK8/PPP2R2D/CXCL8	1.89825586938516
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/383	105/9376	1.86517468606241	SMURF1/EIF2AK3/RAB5A/ARIH1/HUWE1/MAPK8/SIAH1/SQSTM1	1.83978846455009
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	8/383	109/9376	1.79672790859223	NFKB1/NFKBIA/AKT3/STAT3/FOXO1/PRKCE/MAPK8/PTPN11	1.7265788882743
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	5/383	56/9376	2.18575158522939	NFKB1/NFKBIA/NFKB2/HSPD1/CXCL8	1.83659120281301
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	9/383	130/9376	1.69479815223941	NFKB1/NFKBIA/AKT3/TGFB1/MAPK1/MAPK8/GNB1/VEGFA/MAP2K1	1.64621333331477
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	6/383	75/9376	1.95843342036554	BIRC3/CDKN1A/BCL2/AKT3/MAPK1/BIRC2	1.7197308696856
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	11/383	169/9376	1.59339997219089	BCL2/AKT3/ITPR1/MAPK1/EIF2AK3/MAPK8/MAP2K1/DDIT4/RB1CC1/WDR45B/SQSTM1	1.60644007916036
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	10/383	150/9376	1.63202785030461	CDKN1A/BRAF/BCL2/SMAD3/AKT3/TGFB1/MAPK1/TCF7/MAP2K1/ABCB1	1.61030391485546
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	14/383	232/9376	1.4772665886378	EZR/PAK1/BRAF/AKT3/CDC42/MAPK1/DIAPH1/VAV1/PIP4K2A/CYFIP2/ITGAX/ROCK1/MAP2K1/PAK2	1.51904151993407
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	9/383	134/9376	1.64420716262032	BRAF/ITPR1/MAPK1/PRKCH/PRKCE/ROCK1/ACTG2/ITPR3/MAP2K1	1.54998571195345
Organismal Systems	Nervous system	hsa04730	Long-term depression	5/383	60/9376	2.04003481288077	BRAF/ITPR1/MAPK1/ITPR3/MAP2K1	1.66779047940324
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	8/383	115/9376	1.70298558292655	BRAF/ITPR1/MAPK1/SLC18A2/GNB1/PTGS2/ITPR3/MAP2K1	1.56530554966667
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/383	154/9376	1.58963751653047	BCL2/AKT3/PPP2R5C/MAPK1/ATP1B3/CREM/RPS6KA5/ATP2A2/ATP2A3/PPP2R2D	1.52252922713704
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	8/383	116/9376	1.68830467272891	EZR/RHOH/RASSF5/CDC42/VAV1/ROCK1/PLCG2/PTPN11	1.53934848155202
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	8/383	116/9376	1.68830467272891	SLC38A1/GLS/ITPR1/MAPK1/SLC38A2/GNB1/ITPR3/HOMER1	1.53934848155202
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	7/383	99/9376	1.73093862911095	CDKN1A/BRAF/BCL2/AKT3/MAPK1/MAPK8/MAP2K1	1.5087853615948
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	7/383	99/9376	1.73093862911095	AKT3/MAPK1/RALGDS/MAPK8/DGKA/MAP2K1/CHKA	1.5087853615948
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/383	100/9376	1.71362924281984	CD44/HLA-DQA2/HLA-DRB5/IL4R/KIT/HLA-DQB1/CD55	1.48055653845962
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/383	102/9376	1.68002866943122	ITPR1/CPA3/RAB11A/ATP1B3/ITPR3/ATP2A2/ATP2A3	1.42503815021982
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	4/383	47/9376	2.08343980889951	MAPK1/PRKCE/MAPK8/SOCS1	1.53662855637428
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	5/383	65/9376	1.88310905804378	AKT3/ITPR1/MAPK1/ITPR3/MAP2K1	1.4743669358023
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	9/383	144/9376	1.53002610966057	JARID2/SMAD3/AKT3/SKIL/STAT3/MAPK1/TCF7/MAP2K1/TCF3	1.32270605173367
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	9/383	144/9376	1.53002610966057	NFKB1/NFKBIA/AKT3/FOXO1/TRAF3/LPIN1/TCF7/MAPK8/CXCL8	1.32270605173367
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/383	144/9376	1.53002610966057	AKT3/ITPR1/ATXN2L/MAPK8/GTF2B/ITPR3/RB1CC1/ATP2A2/ATP2A3	1.32270605173367
Organismal Systems	Immune system	hsa04611	Platelet activation	8/383	126/9376	1.55431223838535	FYN/AKT3/ITPR1/MAPK1/ROCK1/RASGRP1/ITPR3/PLCG2	1.292711469091
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	7/383	107/9376	1.60152265684097	AKT3/ITPR1/FOXO1/PFKP/CREBBP/ITPR3/EP300	1.29139816891481
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	3/383	33/9376	2.22549252314265	STX5/STX11/STX3	1.45531561742127
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/383	89/9376	1.65036524188107	ITPR1/MAPK1/CSNK1D/TUBB4B/ITPR3/MAP2K1	1.27217639130273
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	19/383	362/9376	1.28488380479783	NFKB1/CDKN1A/BCL2/AKT3/NR4A1/HSP90AB1/PPP2R5C/CCND3/MAPK1/IL4R/IL2RG/GNB1/VEGFA/KIT/MAP2K1/DDIT4/YWHAZ/PPP2R2D/AREG	1.14076450039824
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/383	110/9376	1.55784476619986	BRAF/AKT3/HSP90AB1/MAPK1/STK10/MAPK8/MAP2K1	1.21449655133622
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/383	133/9376	1.47250633110191	AKT3/PPP2R5C/ITPR1/SLC18A2/MAPK8/GNB1/ITPR3/PPP2R2D	1.13255605014287
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	12/383	217/9376	1.35375582052917	NFKB1/BCL2/AKT3/HSP90AB1/STAT3/CCND3/MAPK1/KPNA1/KPNB1/KPNA4/VEGFA/MAP2K1	1.08803323163968
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/383	73/9376	1.67674094209378	CDKN1A/BRAF/AKT3/MAPK1/MAP2K1	1.19785734352836
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	6/383	93/9376	1.57938179061737	ITPR1/CDC42/MAPK1/MAPK8/ITPR3/MAP2K1	1.15876366625216
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	9/383	155/9376	1.42144361155563	CDKN1A/BRAF/NR4A1/ITPR1/MAPK1/TCF7/PDE8A/ITPR3/MAP2K1	1.09181496210089
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	6/383	95/9376	1.546131647657	HLA-DQA2/TGFB1/HLA-DRB5/VEGFA/HLA-DQB1/CXCL8	1.10406460943293
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	4/383	56/9376	1.74860126818351	BCL2/SMURF1/CSNK1D/CUL1	1.15949623908327
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/383	20/9376	2.44804177545692	FDFT1/CYP51A1	1.33777695696295
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	6/383	97/9376	1.51425264461253	PER1/ITPR1/MAPK1/GNB1/RPS6KA5/ITPR3	1.05061728596523
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	2/383	21/9376	2.33146835757802	CHST11/CHST15	1.26052461202079
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	5/383	78/9376	1.56925754836982	INPP5A/ITPKB/PIP4K2A/SYNJ2/PLCG2	1.04182327825848
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	5/383	78/9376	1.56925754836982	NFKB1/IRF1/MAPK1/MAPK8/CXCL8	1.04182327825848
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	6/383	99/9376	1.4836616820951	ITPR1/PRKCH/PRKCE/MAPK8/ITPR3/PLCG2	0.99836242995804
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	12/383	227/9376	1.29411900024154	NFKB1/NFKBIA/NFE2L2/BRAF/AKT3/MAPK1/MAPK8/PRKD2/VEGFA/MAP2K1/PRKD3/PTPN11	0.925724854962868
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	8/383	142/9376	1.37917846504615	NFKB1/NFE2L2/BCL2/AKT3/HSP90AB1/MAPK8/VEGFA/SQSTM1	0.939562402482438
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/383	101/9376	1.45428224284569	MAPK1/TCF7/CREBBP/KIT/MAP2K1/EP300	0.947244773080917
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/383	23/9376	2.12873197865819	GLS/ATP1B3	1.11843824341642
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	8/383	148/9376	1.32326582457131	NFKB2/CDKN1A/BRAF/AKT3/MAPK1/TCF7/KIT/MAP2K1	0.818030670445185
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	12/383	238/9376	1.2343067775413	NFKB1/NFKBIA/RPS26/STAT3/MAPK1/STAT1/TRAF3/RPS4Y1/MAPK8/PLCG2/RSL24D1/CXCL8	0.755580047935656
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	3/383	44/9376	1.66911939235699	RAB5A/RAB11A/ARHGDIB	0.918068990234975
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	4/383	65/9376	1.50648724643503	NR4A1/ITPR1/PDE8A/ITPR3	0.845589842780587
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/383	86/9376	1.42328010200984	LMNA/TCF7/EMD/ATP2A2/ATP2A3	0.813770515178249
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/383	45/9376	1.63202785030461	ABCC1/ABCG1/ABCB1	0.877023249632507
Genetic Information Processing	Transcription	hsa03040	Spliceosome	12/383	243/9376	1.20890951874416	HNRNPM/DDX39B/HNRNPC/WBP11/FUS/SF3B1/SRSF7/RBM25/SF3B2/RBM8A/SNRNP200/SLU7	0.680906319764992
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	5/383	90/9376	1.36002320858718	NFKB1/AKT3/FOXO1/RB1CC1/CAMK4	0.708223187498881
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	8/383	157/9376	1.24740982188888	NFKB1/AKT3/TGFB1/CDC42/EIF2AK3/MAPK8/DDIT3/CXCL8	0.645145368510451
NA	NA	hsa03272	Virion - Hepatitis viruses	3/383	48/9376	1.53002610966057	CHMP1B/IST1/CHMP4B	0.759724868081359
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/383	91/9376	1.3450778986027	PDE7A/GRK5/PDE8A/PDE4A/GNB1	0.682620953779837
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	2/383	29/9376	1.68830467272891	PAK1/RASSF2	0.766083879977456
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/383	29/9376	1.68830467272891	SLC24A1/GNB1	0.766083879977456
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	7/383	138/9376	1.24176032088394	PPP2R5C/ITPR1/MAPK1/ITPR3/MAP2K1/CUL1/YWHAZ	0.590429864164992
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	17/383	368/9376	1.13088886366216	BCL2/NUP153/EIF2AK3/NUP98/RAB5A/ATXN2L/TUBB4B/FUS/NXF1/RANBP2/SRSF7/HNRNPA2B1/ITPR3/RB1CC1/SETX/DDIT3/SQSTM1	0.528621893965018
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	3/383	50/9376	1.46882506527415	TGFB1/CD40/CXCL8	0.685931658645561
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	9/383	184/9376	1.19741173799523	PAK1/FYN/CDC42/MAPK1/ROCK1/SEMA4A/PLCG2/PAK2/PTPN11	0.558096892242646
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	7/383	139/9376	1.23282679339557	BCL2/AKT3/HSP90AB1/ITPR1/MAPK1/ITPR3/MAP2K1	0.570699659816583
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/383	30/9376	1.63202785030461	NFKB1/ABCC1	0.715511607200151
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/383	31/9376	1.57938179061737	SRP54/SRPRA	0.666789518196983
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	4/383	75/9376	1.30562228024369	CDKN1A/BCL2/CCND3/SIAH1	0.548382452688603
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	4/383	75/9376	1.30562228024369	ITPR1/ATP1B3/ALB/ITPR3	0.548382452688603
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	4/383	76/9376	1.28844303971417	PPARD/SORBS1/PLIN2/ACSL3	0.521024462215723
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/383	76/9376	1.28844303971417	EZR/ITPR1/ATP1B3/ITPR3	0.521024462215723
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/383	32/9376	1.53002610966057	PFKP/GALM	0.619781439999889
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	5/383	99/9376	1.23638473507925	TGFB1/LMNA/EMD/ATP2A2/ATP2A3	0.487939498321278
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/383	55/9376	1.33529551388559	B4GALT5/GALC/SAMD8	0.514648323089509
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	8/383	170/9376	1.15201965903855	EZR/CDC42/PRKCE/MAPK8/ROCK1/HSPA4/WHAMM/PPP2R2D	0.412782672045345
Cellular Processes	Cell motility	hsa04814	Motor proteins	9/383	194/9376	1.1356894834594	MYO9B/KIF13B/TUBB4B/BICDL1/MYO1D/ACTG2/HOOK3/KIF2A/CAPZA1	0.394104268267687
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/383	105/9376	1.16573417878901	TGFB1/LMNA/EMD/ATP2A2/ATP2A3	0.352432676579379
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	2/383	36/9376	1.36002320858718	B4GALT5/GALNT2	0.44662295312021
NA	NA	hsa04518	Integrin signaling	7/383	154/9376	1.11274626157133	AKT3/TGFB1/CCND3/CDC42/FLNA/ITGAX/VEGFA	0.291127130958116
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	7/383	155/9376	1.10556725343216	HLA-DQA2/HLA-DRB5/RAB5A/TUBB4B/HLA-F/HLA-B/HLA-DQB1	0.273488323573534
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/383	61/9376	1.20395497153619	ATP1B3/MT1G/MT2A	0.329792300649046
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/383	38/9376	1.28844303971417	MAPK1/ATP1B3	0.367669543309425
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	2/383	38/9376	1.28844303971417	IL2RG/CD40	0.367669543309425
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	11/383	254/9376	1.06017557204827	NFATC1/ITPR1/ITPKB/CAMK1D/STIM2/VEGFA/ITPR3/ATP2A2/PLCG2/ATP2A3/CAMK4	0.200643354631743
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	3/383	62/9376	1.18453634296303	CREBBP/SPEN/EP300	0.300844700889573
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	7/383	158/9376	1.08457547013914	BRAF/SLC7A5/AKT3/MAPK1/LPIN1/MAP2K1/DDIT4	0.221252069036096
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	7/383	160/9376	1.0710182767624	HLA-DQA2/CD58/HLA-DRB5/HLA-F/HLA-B/CD40/HLA-DQB1	0.186978476500968
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	4/383	89/9376	1.10024349458738	SLC38A1/GLS/SLC38A2/GNB1	0.196085828367604
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	20/383	480/9376	1.02001740644038	NFKB1/BRAF/BCL2/UBE2G1/ITPR1/MAPK1/EIF2AK3/RAB5A/ATXN2L/TUBB4B/FUS/MAPK8/PTGS2/ITPR3/MAP2K1/RB1CC1/ATP2A2/DDIT3/ATP2A3/SQSTM1	0.0929102796750806
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	2/383	42/9376	1.16573417878901	SLC39A8/ACSL3	0.222144495372038
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	16/383	388/9376	1.00950176307502	NFKB1/BRAF/AKT3/ITPR1/MAPK1/EIF2AK3/TUBB4B/MAPK8/PTGS2/SLC39A8/ITPR3/MAP2K1/RB1CC1/ATP2A2/DDIT3/ATP2A3	0.0394476609270006
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/383	18/9376	1.36002320858718	ACSL3	0.315506244114711
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/383	44/9376	1.11274626157133	TAF4B/GTF2B	0.154694136346794
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/383	19/9376	1.28844303971417	IDS	0.259717538336947
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	5/383	122/9376	1.00329580961349	AKT3/PPP2R5C/FOXO1/PFKP/PPP2R2D	0.00756153579591362
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/383	20/9376	1.22402088772846	UAP1	0.206962248300434
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/383	149/9376	0.985788634412182	ITPR1/MAPK1/MAPK8/GNB1/PTGS2/ITPR3	-0.0360853908994843
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	4/383	100/9376	0.979216710182768	CCR7/IL2RG/IL18R1/CXCL8	-0.0431187986467825
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	2/383	48/9376	1.02001740644038	AKT3/ATP1B3	0.0286924006007738
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/383	49/9376	0.999200724676293	NFKB1/SLC18A2	-0.00115759378162369
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/383	22/9376	1.11274626157133	HDC	0.109256563571243
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	5/383	128/9376	0.956266318537859	PDE7A/ADK/PDE8A/AMPD3/PDE4A	-0.102808693506433
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	4/383	103/9376	0.9506958351289	NFKB1/TGFB1/RAB5A/CXCL8	-0.103830469528225
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	9/383	233/9376	0.945595535584218	DIAPH1/LMNA/SPTAN1/AMPD3/ATP1B3/EMD/ACTG2/FMNL1/CAPZA1	-0.173540509574733
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/383	23/9376	1.0643659893291	GLS	0.0637789886369413
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	1/383	23/9376	1.0643659893291	IDI1	0.0637789886369413
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/383	23/9376	1.0643659893291	CPA3	0.0637789886369413
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4/383	104/9376	0.941554529021892	SAMD8/LPIN1/DGKA/CHKA	-0.123684007765136
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	2/383	51/9376	0.960016382532125	PAFAH1B1/PAFAH1B2	-0.0590847605871433
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	2/383	53/9376	0.923789349229026	RAB11A/ATP1B3	-0.114817607034107
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	10/383	268/9376	0.913448423677955	NFE2L2/UBE2G1/ITPR1/EIF2AK3/TUBB4B/SLC18A2/MAPK8/SLC39A8/ITPR3/DDIT3	-0.296663144946552
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	1/383	26/9376	0.941554529021892	ABCC1	-0.0615835130505739
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/383	191/9376	0.897188085245991	BRAF/MAPK1/HDAC4/SLC18A2/GNB1/MAP2K1/CAMK4	-0.296246534897478
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/383	27/9376	0.906682139058118	ACSM3	-0.100206710537962
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/383	27/9376	0.906682139058118	ELOVL5	-0.100206710537962
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	11/383	298/9376	0.9036395815445	TGFB1/CCR7/IL4R/IL2RG/IL21R/CD40/IL18R1/RELT/IL32/IL1RL1/CXCL8	-0.348854595701843
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	3/383	85/9376	0.864014744278913	ADK/AMPD3/NT5C3A	-0.259897907910296
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/383	57/9376	0.858962026476112	ELOVL5/ACSL3	-0.220405059492038
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/383	28/9376	0.874300634091757	ELOVL5	-0.137462892837057
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/383	28/9376	0.874300634091757	GCH1	-0.137462892837057
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/383	87/9376	0.844152336364455	ATP1B3/ATP2A2/ATP2A3	-0.301375656448445
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	5/383	143/9376	0.855958662747174	HLA-DQA2/HLA-DRB5/CD40/RO60/HLA-DQB1	-0.358192488376198
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2/383	59/9376	0.829844669646413	AKT3/PTGS2	-0.270561653928937
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	11/383	308/9376	0.874300634091757	POLR2A/ITPR1/RCOR1/TUBB4B/MAPK8/CREBBP/TAF4B/RB1CC1/EP300/NRF1/SIN3A	-0.462898120994006
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/383	31/9376	0.789690895308684	PFKP	-0.242037131405417
NA	NA	hsa04981	Folate transport and metabolism	1/383	31/9376	0.789690895308684	ABCC1	-0.242037131405417
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	2/383	62/9376	0.789690895308684	AKT3/FOXO1	-0.342861350123808
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/383	63/9376	0.777156119192673	CDKN1A/TCF7	-0.366234214553401
Organismal Systems	Digestive system	hsa04970	Salivary secretion	3/383	93/9376	0.789690895308684	ITPR1/ATP1B3/ITPR3	-0.420618240243008
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	7/383	205/9376	0.835916703814558	NFKB1/SMAD3/AKT3/TGFB1/MAPK8/ATP2A2/ATP2A3	-0.490191395939374
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/383	65/9376	0.753243623217514	LPIN1/DGKA	-0.41196434326284
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/383	34/9376	0.720012286899094	POLR2A	-0.337513562352505
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/383	67/9376	0.730758738942364	PFKP/GALM	-0.456415338082225
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1/383	35/9376	0.699440507273405	PFKP	-0.367621170650426
NA	NA	hsa04519	Cadherin signaling	14/383	404/9376	0.848331308326655	NFKB1/NFKBIA/CDC42/MAPK1/VAV1/CYFIP2/TCF7/MAPK8/CREBBP/MYO1D/ROCK1/MAP2K1/EP300/YWHAZ	-0.643094387020795
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/383	99/9376	0.741830841047551	HLA-DQA2/HLA-DRB5/HLA-DQB1	-0.532906364952246
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1/383	36/9376	0.680011604293589	GBE1	-0.396958192821589
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/383	69/9376	0.709577326219397	ITPR1/ITPR3	-0.499669609953484
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	2/383	69/9376	0.709577326219397	SLC18A2/CAMK4	-0.499669609953484
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/383	37/9376	0.661632912285654	GLS	-0.425570500672014
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/383	37/9376	0.661632912285654	UAP1	-0.425570500672014
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/383	38/9376	0.644221519857084	UAP1	-0.45349997504912
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	3/383	103/9376	0.713021876346675	CPA3/SLC38A2/ATP1B3	-0.604352054256571
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	8/383	250/9376	0.783373368146214	AP1S3/LITAF/IDS/VPS13A/GALC/AP1G1/GGA2/GNPTAB	-0.716430964295415
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	6/383	195/9376	0.753243623217514	NFKB1/AKT3/MAPK1/HDAC4/MAP2K1/PLCG2	-0.718577186718404
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	2/383	78/9376	0.627703019347928	CDC42/SEPTIN6	-0.681357079900673
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/383	43/9376	0.569312040803935	ACSL3	-0.584142834429611
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	2/383	79/9376	0.619757411508081	SLC18A2/STX3	-0.700383032630437
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/383	44/9376	0.556373130785663	MAN2A1	-0.608680717541387
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/383	44/9376	0.556373130785663	TDG	-0.608680717541387
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/383	46/9376	0.532182994664548	PSME4	-0.656367134462224
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	2/383	83/9376	0.58988958444745	NFKB1/NFKBIA	-0.774452177637122
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/383	49/9376	0.499600362338147	GALNT2	-0.724730880215122
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/383	86/9376	0.569312040803935	ATP1B3/ITPR3	-0.82801237471802
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/383	183/9376	0.668863873075661	NOP58/SBDS/NXF1/FBL/DKC1	-0.933547043968106
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	8/383	275/9376	0.712157607405649	FYN/ITPR1/MAPK1/EIF2AK3/TUBB4B/MAPK8/ITPR3/DDIT3	-0.999791117838619
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	2/383	88/9376	0.556373130785663	ITGAX/CD55	-0.862841059511894
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/383	51/9376	0.480008191266063	PLCG2	-0.768404498442527
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	1/383	52/9376	0.470777264510946	PTGS2	-0.789717498427385
Organismal Systems	Digestive system	hsa04976	Bile secretion	2/383	90/9376	0.544009283434871	ATP1B3/ABCB1	-0.897006612498583
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	1/383	54/9376	0.453341069529059	WDR48	-0.831364558607487
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	1/383	56/9376	0.437150317045878	MAN2A1	-0.871788652105958
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	1/383	59/9376	0.414922334823207	NT5C3A	-0.930323960102595
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/383	63/9376	0.388578059596336	PTGS2	-1.00484533518808
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	1/383	63/9376	0.388578059596336	POLR2A	-1.00484533518808
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/383	70/9376	0.349720253636703	PTGS2	-1.12693911226761
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/383	75/9376	0.326405570060923	PFKP	-1.2086401728069
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/383	83/9376	0.294944792223725	ACSL3	-1.33142568515616
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/383	86/9376	0.284656020401967	ITPR3	-1.37527333801678
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	1/383	89/9376	0.275060873646845	CD44	-1.41805001603508
Genetic Information Processing	Translation	hsa03010	Ribosome	4/383	222/9376	0.441088608190436	RPS26/RPS4Y1/RSL24D1/DAP3	-1.73918877286881
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	1/383	116/9376	0.211038084091114	PFKP	-1.76446183699677
NA	NA	hsa04082	Neuroactive ligand signaling	2/383	199/9376	0.246034349292153	SLC18A2/GNB1	-2.21850525356065
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/383	154/9376	0.158963751653047	GCH1	-2.17167706139974
NA	NA	hsa04382	Cornified envelope formation	2/383	217/9376	0.225625970088195	PPP2R5C/PPP2R2D	-2.38171255246753
NA	NA	hsa04081	Hormone signaling	2/383	219/9376	0.223565458945837	STAT3/GNB1	-2.39929156004771
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/383	235/9376	0.208343980889951	SMARCA2/ACSL3	-2.53633329770828
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/383	449/9376	0.109044177080486	RGS2/GNB1	-3.99263217400681