category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	75/1161	181/9376	3.34632461061858	HLA-DRA/CTSS/HLA-DRB5/CD74/ATP6V1H/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/NFKB1/HLA-DPA1/IL1B/ITGAX/RAB7A/FCGR2A/SPHK1/HLA-DMA/HLA-DQA2/CREBBP/IRAK2/MAPK13/MALT1/CLEC7A/RAB5A/BCL2/TNF/BID/IL10RA/PLK3/TLR1/SRC/CLEC4E/HLA-DMB/IRAK1/IL18/ATP6V0D1/CALM1/SYK/CYCS/ITGB2/IL1A/RIPK2/TLR2/MAPK8/RAF1/FCER1G/EP300/JAK1/LSP1/HSPA9/CASP3/FCGR1A/IL10/HLA-DOA/BCL10/VDR/IFNGR1/RELA/CTSD/NFYC/EEA1/PPP3R1/C3/CEBPG/CORO1A/FCGR2B/TGFB1/RHOA/ITGAM/PPP3CC/IL23A/CIITA/FCGR3A/AKT3/NOD2	11.9825563712237
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	74/1161	216/9376	2.76670813793984	NFKBIA/CXCL8/SOD2/MAP2K3/CXCL2/PIK3CB/NFKB1/CCL3/ABCA1/IL1B/NFE2L2/HSPA5/CCL3L1/TANK/CXCL3/ATF4/TRAF3/PIK3R1/OLR1/EIF2AK3/XBP1/MAPK13/ABCG1/BCL2/TNF/BID/MAP3K5/SRC/ERN1/NCF2/TBK1/NFATC1/TAB2/CASP1/IRAK1/IL18/ICAM1/IRF7/CALM1/RAP1B/CYCS/ITPR1/MMP9/TICAM1/DDIT3/NLRP3/CDC42/TLR2/MAPK8/GSK3B/CD40/FAS/POU2F1/KRAS/HSP90AB1/ATF6/CASP3/LY96/RAP1A/TNFRSF10B/BCL2L1/HSPA6/VAV3/VAV2/RELA/PPP3R1/RHOA/PPP3CC/PPARG/CCL5/AKT3/TICAM2/LYN/MAP2K4	9.87510932844245
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	71/1161	205/9376	2.79698325665427	NFKBIA/HLA-DRA/HLA-DRB5/MAP2K3/NCOR2/HLA-DQB1/PIK3CB/HLA-DQA1/HLA-DPB1/HLA-DRB1/NFKB1/HLA-DPA1/CD44/CD58/VIM/TNFAIP3/NFKB2/HLA-DMA/HLA-DQA2/HLA-E/GADD45B/TRAF3/PIK3R1/CDKN1A/HLA-F/MAPK13/HLA-B/BCL2/TNF/BID/RIPK1/PLCG2/NFKBIE/TBK1/HLA-DMB/TAB2/GADD45A/USP7/IRAK1/ICAM1/IRF7/SYK/GADD45G/CYCS/PDIA3/PSMD12/HLA-A/NFKBIB/TLR2/MAPK8/BCL2L11/RUNX3/CD40/IFNAR2/FAS/JAK1/OAS2/RELB/CASP3/PSMD7/SNW1/HLA-DOA/HES1/DDB2/RELA/SIN3A/PSMD14/AKT3/MYC/LYN/MAP2K4	9.77936326102536
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	67/1161	196/9376	2.76060398319535	NFKBIA/CXCL8/PIK3R5/CXCL2/PIK3CB/NFKB1/MAPKAPK2/PTGS2/UBC/CXCL3/CREBBP/TCF7L2/HLA-E/TRAF3/PIK3R1/CDKN1A/HLA-F/MAPK13/HLA-B/BID/MAP2K1/SRC/CTNNB1/PLCG2/MAP1LC3B/TBK1/NFATC1/PREX1/ICAM1/IRF7/CALM1/SYK/CYCS/ITPR1/HLA-A/CLEC2B/TICAM1/MAPK8/GSK3B/TCF7/RAF1/HCK/CD86/IFNAR2/GNG5/FAS/CSF2/KRAS/EP300/JAK1/CASP3/ZFP36/IFNGR1/ATG3/RELA/CCR5/GNG7/PPP3R1/GNB1/C3/PPP3CC/AKT3/MYC/CCR1/LYN/PIK3CG/MAP2K4	9.36410639120643
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	45/1161	105/9376	3.46105574012551	NFKBIA/TRAF1/CXCL8/BCL2A1/CXCL2/NFKB1/IL1B/CFLAR/TNFAIP3/NFKB2/PTGS2/CXCL3/CYLD/BIRC2/GADD45B/TRAF3/PRKCB/MALT1/BCL2/TNF/RIPK1/PLCG2/TAB2/GADD45A/IL1R1/IRAK1/ICAM1/SYK/GADD45G/CCL4/TICAM1/TNFRSF11A/BIRC3/CD40/TRIM25/RELB/LY96/BCL2L1/BCL10/PLAU/RELA/UBE2I/TNFSF14/TICAM2/LYN	9.53346492935386
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	62/1161	180/9376	2.78166331706383	NFKBIA/HLA-DRA/HLA-DRB5/CD74/HLA-DQB1/PIK3CB/HLA-DQA1/HLA-DPB1/HLA-DRB1/NFKB1/HLA-DPA1/IL1B/SRSF5/HLA-DMA/BIRC2/HLA-DQA2/HLA-E/TRAF3/PIK3R1/HLA-F/NXF1/HLA-B/RHEB/PILRA/BCL2/TNF/BID/SRC/SRSF3/TBK1/HLA-DMB/TAB2/IFIH1/SRSF4/IRAK1/SRSF2/IRF7/SYK/CYCS/PDIA3/SRSF6/HLA-A/TNFRSF14/TICAM1/TLR2/BIRC3/IFNAR2/FAS/POU2F1/JAK1/OAS2/CASP3/BCL2L1/HLA-DOA/IFNGR1/BST2/RELA/CGAS/C3/TNFSF14/CCL5/AKT3	9.07319769481023
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	59/1161	173/9376	2.75417345023475	NFKBIA/HLA-DRA/CXCL8/HLA-DRB5/DNAJC3/HLA-DQB1/PIK3CB/HLA-DQA1/HLA-DPB1/HLA-DRB1/NFKB1/HLA-DPA1/IL1B/HLA-DMA/HLA-DQA2/CREBBP/TRAF3/PIK3R1/NXF1/PRKCB/TNF/BID/MAP2K1/RAB11A/TBK1/HLA-DMB/CASP1/IFIH1/IL18/ICAM1/IRF7/CYCS/RSAD2/NUP98/TICAM1/IL1A/NLRP3/NFKBIB/RAF1/KPNA2/TRIM25/IFNAR2/FAS/EP300/JAK1/OAS2/CASP3/TNFRSF10B/MX2/HLA-DOA/NXT2/IFNGR1/ADAR/RELA/DNAJB1/MX1/CIITA/CCL5/AKT3	8.75444942914564
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	36/1161	78/9376	3.72729079705824	NFKBIA/HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/NFKB1/HLA-DPA1/IL1B/FCGR2A/PTGS2/HLA-DMA/HLA-DQA2/PRKCB/MAPK13/TNF/NCF2/HLA-DMB/TAB2/IRAK1/ITGB2/IL1A/NFKBIB/TLR2/JAK1/FCGR1A/IL10/HLA-DOA/IFNGR1/RELA/C3/TGFB1/ITGAM/FCGR3A/ITGA4	9.09247135687842
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	44/1161	112/9376	3.17263442844838	NFKBIA/HLA-DRA/PIK3R5/HLA-DRB5/MAP2K3/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/NFKB1/HLA-DPA1/HLA-DMA/BIRC2/HLA-DQA2/MAPK13/PPIF/BCL2/TNF/IL10RA/HLA-DMB/TAB2/IRAK1/CYCS/NFKBIB/TLR2/MAPK8/GNAI3/BIRC3/CD40/JAK1/CASP3/LY96/BCL2L1/HSPA6/IL10/HLA-DOA/IFNGR1/RELA/CCR5/TGFB1/ALOX5/CIITA/AKT3/PIK3CG	8.69549599883233
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	42/1161	105/9376	3.23031869078381	NFKBIA/PIK3CB/NFKB1/IL1B/NFKB2/MAPKAPK2/PTGS2/CYLD/PIK3R1/MAPK13/MALT1/CLEC7A/TNF/PLK3/SRC/PLCG2/CLEC4E/MRAS/NFATC1/CASP1/IRF1/CALM1/SYK/ITPR1/NLRP3/PRKCD/MAPK8/RAF1/FCER1G/KRAS/BCL3/LSP1/RELB/IL10/BCL10/RELA/PPP3R1/RHOA/PPP3CC/IL23A/CBLB/AKT3	8.6396519482267
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	68/1161	227/9376	2.41918139838435	NFKBIA/CXCL8/PIK3CB/NFKB1/CCL3/IL1B/IL6R/CCL3L1/PTGS2/AKAP13/HLA-E/ATF4/PIK3R1/CDKN1A/HLA-F/PRKCB/MAPK13/HLA-B/RHEB/PTGER4/ADCY3/TNF/BID/IL10RA/CXCR4/MAP2K1/SRC/RIPK1/CTNNB1/TBK1/ITGAV/NFATC1/IL1R1/GNA13/CALM1/CYCS/ITPR1/PDIA3/HLA-A/CCL4/GNA12/GSK3B/RAF1/GNAI3/PTGER2/ATF2/PTK2B/GRB2/GNG5/FAS/KRAS/JAK1/ADCY9/CASP3/SOS2/RELA/CCR5/GNG7/RPS6KB1/PPP3R1/CGAS/GNB1/RHOA/PPP3CC/CCL5/AKT3/MYC/CCR1	8.1369564028246
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	45/1161	119/9376	3.05387271187545	NFKBIA/TRAF1/MAP2K3/CXCL2/PIK3CB/NFKB1/IL1B/CFLAR/TNFAIP3/PTGS2/CXCL3/CYLD/CCL20/BIRC2/ATF4/MAP3K8/TRAF3/PIK3R1/MAPK13/TNF/MAP3K5/MAP2K1/RIPK1/TAB2/IRF1/ICAM1/IL15/TNFRSF1B/MMP9/ADAM17/MAPK8/ATF2/BIRC3/FAS/CSF2/BCL3/CASP3/RHBDF2/RELA/CCL5/AKT3/EDN1/MAP2K4/NOD2/RPS6KA5	8.47636867490462
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	39/1161	95/9376	3.31532707738338	HLA-DRA/CXCL8/HLA-DRB5/ATP6V1H/HLA-DQB1/CXCL2/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/CCL3/IL1B/CCL3L1/CXCL3/CCL20/HLA-DMA/HLA-DQA2/TNF/HLA-DMB/IL18/ICAM1/IL15/ATP6V0D1/ACP5/ITGB2/IL1A/TNFRSF11A/TLR2/ATP6V1F/TNFSF13/CD86/ATP6V1B2/CSF2/HLA-DOA/CD80/TGFB1/CTSL/IL23A/CCL5	8.52657725427087
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	66/1161	224/9376	2.37947582133629	NFKBIA/HLA-DRA/HLA-DRB5/HLA-DQB1/PIK3CB/HLA-DQA1/HLA-DPB1/ETS2/HLA-DRB1/NFKB1/HLA-DPA1/NFKB2/HLA-DMA/HLA-DQA2/CREBBP/HLA-E/ATF4/PIK3R1/CDKN1A/HLA-F/HLA-B/MAD1L1/ADCY3/TNF/MAP2K1/HLA-DMB/NFATC1/STAT5A/IL1R1/ICAM1/IL15/SMAD2/FOSL1/SPI1/ITGB2/HLA-A/MAPK8/ATF2/CD40/CSF2/KRAS/EP300/JAK1/ADCY9/RELB/NRP1/BCL2L1/HLA-DOA/PTTG1/ZFP36/CD4/RELA/CANX/PPP3R1/KAT5/TGFB1/PTEN/CHEK1/PPP3CC/MAP3K1/TRRAP/AKT3/MYC/CDKN2B/MAP2K4/IL2RA	7.85557646694956
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	70/1161	253/9376	2.23441016160935	NFKBIA/CXCL8/PIK3CB/NFKB1/UBE2D1/IL1B/CD44/FNBP1/UBC/TNIP1/PIK3R1/ARHGEF2/MAPK13/MALT1/CUL1/BCL2/TNF/SRC/RIPK1/PLCG2/MAP1LC3B/FOXO3/TBK1/TAB2/ARF1/RPTOR/PPID/CASP1/CYTH1/IL1R1/IL18/UBE2N/CYCS/ITPR1/ACTR3/NLRP3/RIPK2/UBE2D3/NFKBIB/HK2/TIFA/PRKCD/CDC42/RRAGD/WASL/MAPK8/CAPN2/GSK3B/CSF2/PRKCE/ATG12/HCLS1/RRAGC/BCL2L1/BCL10/ATG5/ARPC5/RELA/RPS6KB1/FBXW11/CGAS/C3/RHOA/SEPTIN6/CAST/SEPTIN9/FOXO1/CCL5/AKT3/RPS6KA5	7.48253704246934
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	47/1161	142/9376	2.67297497300773	NFKBIA/LCP2/PIK3CB/NFKB1/IL1B/FCGR2A/NFKB2/CYLD/FOSL2/TYROBP/PIK3R1/MAPK13/TNF/ATP2A2/MAP2K1/SIRPA/PLCG2/NCF2/NFATC1/TAB2/IL1R1/TREM2/SYK/FOSL1/ACP5/ITPR1/SPI1/IL1A/TNFRSF11A/MAPK8/LILRB4/IFNAR2/GRB2/JAK1/RELB/FCGR1A/GAB2/IFNGR1/RELA/PPP3R1/LILRB2/FCGR2B/TGFB1/PPP3CC/PPARG/FCGR3A/AKT3	7.55155944427086
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	39/1161	109/9376	2.88950525093047	NFKBIA/HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/NFKB1/HLA-DPA1/IL1B/IL6R/HLA-DMA/HLA-DQA2/MAPK13/AHR/NFKBIE/HLA-DMB/NFATC1/IL4R/STAT5A/IL1R1/SMAD2/RARA/NFKBIB/MAPK8/HSP90AB1/JAK1/HLA-DOA/IFNGR1/CD4/RELA/IRF4/PPP3R1/RUNX1/TGFB1/PPP3CC/IL23A/EBI3/IL2RA	7.45915676886456
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	50/1161	163/9376	2.47723825980353	NFKBIA/CXCL8/MAP2K3/PIK3CB/NFKB1/CREBBP/ATF4/TRAF3/PIK3R1/CDKN1A/PRKCB/MAPK13/BRAF/BCL2/TNF/BID/MAP2K1/SRC/TBK1/NFATC1/TAB2/IFIH1/STAT5A/IRAK1/STAT4/IRF7/DDX3X/CYCS/MMP9/TICAM1/TLR2/MAPK8/RAF1/ATF2/PTK2B/GRB2/FAS/KRAS/EP300/JAK1/CASP3/DDB2/SOS2/RELA/TGFB1/MAP3K1/AKT3/MYC/TICAM2/MAP2K4	7.15223503925239
Human Diseases	Immune disease	hsa05330	Allograft rejection	21/1161	39/9376	4.34850592990128	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-E/HLA-F/HLA-B/TNF/HLA-DMB/HLA-A/CD86/CD40/FAS/IL10/HLA-DOA/CD80	7.87730499084646
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	48/1161	155/9376	2.50089188963908	HLA-DRA/CTSS/HLA-DRB5/ATP6V1H/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/RAB7A/FCGR2A/HLA-DMA/HLA-DQA2/HLA-E/OLR1/HLA-F/HLA-B/CLEC7A/RAB5A/NCF2/ITGAV/HLA-DMB/MSR1/ATP6V0D1/ITGB2/HLA-A/DYNC1LI1/TUBB4B/TLR2/ATP6V1F/M6PR/ATP6V1B2/TUBA1C/FCGR1A/HLA-DOA/TUBB6/EEA1/CANX/TFRC/C3/CORO1A/FCGR2B/ITGAM/CTSL/THBS1/DYNC1H1/STX18/FCGR3A	7.08311369688559
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	44/1161	137/9376	2.59368654004539	NFKBIA/TRAF1/CTSS/BCL2A1/PIK3CB/NFKB1/IL3RA/CFLAR/BIRC2/GADD45B/ATF4/PMAIP1/PIK3R1/EIF2AK3/BCL2/TNF/BID/MAP3K5/MAP2K1/RIPK1/ERN1/GADD45A/CTSH/GADD45G/CYCS/ITPR1/DDIT3/MAPK8/BCL2L11/CAPN2/RAF1/BIRC3/FAS/KRAS/MCL1/TUBA1C/CASP3/TNFRSF10B/BCL2L1/RELA/CTSD/CTSZ/CTSL/AKT3	7.06396711666704
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	33/1161	87/9376	3.06323324126051	EREG/PIK3CB/TCF7L2/GADD45B/PMAIP1/PIK3R1/CDKN1A/BRAF/BCL2/MAP2K1/CTNNB1/GADD45A/SMAD2/GADD45G/CYCS/RALGDS/MAPK8/BCL2L11/GSK3B/TCF7/RAF1/GRB2/KRAS/CASP3/DDB2/SOS2/RPS6KB1/MSH6/TGFB1/RHOA/TGFA/AKT3/MYC	7.26810905784159
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	40/1161	120/9376	2.69193224231984	NFKBIA/PIK3CB/NFKB1/RAPGEF1/MAPKAPK2/ATF4/RPS6KA3/PIK3R1/IRAK2/MAPK13/BRAF/BCL2/MAP3K5/MAP2K1/PSEN1/SH2B3/PLCG2/FOXO3/NFKBIE/IRAK1/CALM1/RAP1B/RIPK2/NFKBIB/PRKCD/CDC42/MAPK8/GSK3B/RAF1/GRB2/KRAS/RAP1A/ARHGDIB/SOS2/RELA/RHOA/MAP3K1/AKT3/PRDM4/RPS6KA5	7.01229020042809
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	65/1161	250/9376	2.09970714900947	LITAF/CTSS/ARL8B/ATP6V1H/AP3B1/RAB7A/LAPTM5/GM2A/MANBA/AP1S3/NPC1/IGF2R/AP1G1/CLN8/RPTOR/CTSH/SLC11A2/PSAP/ATP6V0D1/CD68/ARSB/SLC17A5/SLC36A4/SLC15A3/GLA/ACP5/DTNBP1/SLC11A1/BLOC1S2/TMEM175/PPT1/RRAGD/ATP6V1F/VPS13A/M6PR/BLOC1S6/ATP6V1B2/ARSG/OSBP/PLEKHM1/DMXL2/SLC36A3/LAMP3/LIPA/RRAGC/GNS/TPCN2/DMXL1/GUSB/ABCA5/CTSD/LAMTOR3/ARL8A/SPG11/SLC2A6/CTSZ/ASAH1/MCOLN2/GALC/AP5B1/GGA2/CTSL/BORCS5/VAMP7/SUMF1	6.62528834968664
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	47/1161	157/9376	2.41759519851654	CXCL8/MAP2K3/PIK3CB/NFKB1/MAPKAPK2/HLA-E/GADD45B/PIK3R1/CDKN1A/HLA-F/MAPK13/HLA-B/RHEB/SIRT1/MAP2K1/FOXO3/MRAS/NFATC1/GADD45A/PPID/HIPK2/CALM1/SMAD2/GADD45G/ITPR1/NBN/HLA-A/IL1A/CAPN2/RAF1/RASSF5/KRAS/RELA/FBXW11/PPP3R1/HUS1/TGFB1/PTEN/HIPK3/CHEK1/PPP3CC/RBBP4/FOXO1/AKT3/MYC/CDKN2B/RAD1	6.73376748829056
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	54/1161	193/9376	2.25954934329437	NFKBIA/CXCL8/PIK3R5/CXCL2/PIK3CB/NFKB1/CCL3/TIAM1/FGR/CCL3L1/CXCL3/CCL20/PIK3R1/PRKCB/BRAF/ADCY3/CXCR4/CCR7/MAP2K1/SRC/PLCG2/FOXO3/CXCL16/PREX1/RAP1B/CCL4/NFKBIB/PRKCD/CDC42/GSK3B/RAF1/GNAI3/ARRB2/HCK/PTK2B/GRB2/GNG5/KRAS/ADCY9/RAP1A/VAV3/VAV2/SOS2/RELA/CCR5/GNG7/GNB1/RHOA/WAS/CCL5/AKT3/CCR1/LYN/PIK3CG	6.64659952734366
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	64/1161	248/9376	2.08407657469923	NFKBIA/CXCL8/SNX9/ARL8B/MAP2K3/PIK3CB/NFKB1/IL1B/RAB7A/ABI1/BIRC2/TCF7L2/PLEKHM2/MAPK13/RAB5A/BCL2/TNF/MAP2K1/RIPK1/CTNNB1/TAB2/ARF1/CASP1/KPNA4/CYTH1/IRAK1/IL18/CYCS/ACTR3/ACBD3/DYNC1LI1/NLRP3/RIPK2/RHOG/CYFIP1/TUBB4B/CDC42/RHOH/TLR2/WASL/MAPK8/TXN/TCF7/RAF1/BIRC3/M6PR/HSP90AB1/PLEKHM1/TUBA1C/CASP3/LY96/TNFRSF10B/TUBB6/KIF5B/ARPC5/RELA/ARL8A/RHOA/AHNAK/DYNC1H1/AKT3/MYC/PIK3CG/MAP2K4	6.50423087975681
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	27/1161	66/9376	3.30373502466526	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/NFKB1/HLA-DPA1/IL1B/HLA-DMA/HLA-DQA2/TNF/HLA-DMB/NFATC1/IL4R/IL18/STAT4/SMAD2/IL1A/TLR2/IL10/HLA-DOA/IFNGR1/RELA/TGFB1/IL23A/NOD2	7.06037253051104
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	49/1161	169/9376	2.34150319302377	PIK3CB/CFLAR/RAB7A/C9orf72/RB1CC1/TANK/UBC/PIK3R1/EIF2AK3/IRS2/RHEB/EPG5/BCL2/MAP2K1/MAP1LC3B/ERN1/MRAS/TBK1/RPTOR/MTMR3/GABARAPL1/ITPR1/TP53INP2/PPP2CA/PRKCD/RRAGD/MAPK8/ATG4B/RAF1/DAPK1/KRAS/ATG13/PLEKHM1/ATG12/RRAGC/BCL2L1/MTMR14/ATG5/ATG3/CAMKK2/CTSD/RAB8A/RPS6KB1/WDR45B/ULK2/PTEN/CTSL/RAB1A/AKT3	6.61567185585238
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	21/1161	44/9376	3.85435752877613	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/IL1B/HLA-DMA/HLA-DQA2/HLA-E/HLA-F/HLA-B/TNF/HLA-DMB/HLA-A/IL1A/CD86/FAS/HLA-DOA/CD80	7.13420045797754
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	27/1161	68/9376	3.20656634746922	BCL2A1/PIK3CB/NFKB1/TCF7L2/PIK3R1/BRAF/MAP2K1/STAT5A/SPI1/RARA/TCF7/RAF1/PIM1/GRB2/CSF2/KRAS/FCGR1A/SOS2/RELA/RPS6KB1/CEBPA/RUNX1/ITGAM/PIM2/PPARD/AKT3/MYC	6.86501078193737
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	72/1161	300/9376	1.93819121447028	EREG/MAP2K3/NFKB1/RASGRP3/IL1B/DUSP2/NFKB2/RAPGEF2/MAPKAPK2/DUSP10/GADD45B/ATF4/MAP3K8/RPS6KA3/PRKCB/MAPK13/BRAF/TNF/DUSP5/MAP3K5/MAP2K1/MAP4K4/MAP3K20/DUSP16/MRAS/NFATC1/TAB2/GADD45A/IL1R1/IRAK1/RAP1B/GADD45G/IL1A/DDIT3/GNA12/PPM1A/CDC42/MAPK8/RAF1/MAP3K2/PPM1B/ARRB2/ATF2/GRB2/FAS/KRAS/RELB/CASP3/RAP1A/STK3/HSPA6/NR4A1/MAP3K12/SOS2/PDGFC/RELA/LAMTOR3/STK4/PPP3R1/TAOK3/TGFB1/MAP3K4/PPP3CC/MAP4K3/MAP3K1/MKNK2/TGFA/AKT3/MYC/MAP2K4/RPS6KA5/MET	6.20872908027314
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	36/1161	109/9376	2.66723561624351	NFKBIA/CXCL8/MAP2K3/PIK3CB/NFKB1/CCL3/IL1B/CCL3L1/MAP3K8/TRAF3/PIK3R1/MAPK13/TNF/TLR1/MAP2K1/RIPK1/TBK1/TAB2/IRAK1/IRF7/CCL4/TICAM1/TLR2/MAPK8/CD86/CD40/IFNAR2/JAK1/LY96/CD80/RELA/CCL5/AKT3/IRF5/TICAM2/MAP2K4	6.58170800323035
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	21/1161	45/9376	3.76870513924778	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/IL1B/HLA-DMA/HLA-DQA2/HLA-E/HLA-F/HLA-B/TNF/HLA-DMB/HLA-A/IL1A/CD86/FAS/HLA-DOA/CD80	6.99869122314003
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	32/1161	91/9376	2.83984060728247	NFKBIA/PIK3CB/NFKB1/RASGRP3/PIK3R1/PRKCB/MALT1/MAP2K1/PLCG2/NFKBIE/NFATC1/SYK/NFKBIB/CD22/LILRB4/GSK3B/RAF1/GRB2/CD72/KRAS/VAV3/PIK3AP1/BCL10/VAV2/SOS2/RELA/PPP3R1/LILRB2/FCGR2B/PPP3CC/AKT3/LYN	6.6299141724972
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	27/1161	70/9376	3.11495016611296	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/ABL2/SNTB1/HLA-DMA/HLA-DQA2/HLA-E/CD55/HLA-F/HLA-B/BID/HLA-DMB/ICAM1/CYCS/ITGB2/HLA-A/CD86/EIF4G2/CD40/CASP3/HLA-DOA/CD80	6.67675743619611
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	32/1161	93/9376	2.77876876626564	NFKBIA/HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/NFKB1/HLA-DPA1/NOTCH2/HLA-DMA/HLA-DQA2/MAPK13/NFKBIE/HLA-DMB/NFATC1/IL4R/STAT5A/STAT4/NFKBIB/MAPK8/RUNX3/NOTCH1/MAML1/JAK1/HLA-DOA/IFNGR1/CD4/RELA/PPP3R1/PPP3CC/IL2RA	6.48059316206272
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	41/1161	138/9376	2.3993309116329	NFKBIA/CXCL8/MAP2K3/LCP2/PIK3CB/NFKB1/IL1B/FCGR2A/RPS6KA3/PIK3R1/MAPK13/TNF/MAP2K1/SRC/TBK1/NFATC1/TAB2/CASP1/IRAK1/IL18/ACTR3/TICAM1/NLRP3/RHOG/CDC42/WASL/MAPK8/GSK3B/PTK2B/IL10/VAV3/CD4/VAV2/ARPC5/RELA/FYB1/RHOA/WAS/AKT3/ITGA4/MAP2K4	6.2254242972863
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	33/1161	100/9376	2.66501291989664	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/IL3RA/IL1B/CSF2RA/CD44/IL6R/HLA-DMA/HLA-DQA2/CD55/TNF/CD37/HLA-DMB/CSF3R/IL4R/IL1R1/IL1A/CD22/ANPEP/CSF2/FCGR1A/HLA-DOA/CD4/TFRC/IL7R/ITGAM/ITGA4/IL2RA	6.29267354898666
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	55/1161	214/9376	2.07555523356436	NFKBIA/MAP2K3/PIK3CB/NFKB1/AP1S3/HLA-E/PIK3R1/HLA-F/PRKCB/MAPK13/HLA-B/CUL1/BCL2/TNF/BID/AP1G1/CXCR4/MAP2K1/RIPK1/PLCG2/TBK1/NFATC1/TAB2/IRAK1/CALM1/ELOC/TNFRSF1B/CYCS/ITPR1/PDIA3/HLA-A/TLR2/MAPK8/RAF1/GNAI3/PTK2B/GNG5/FAS/KRAS/CASP3/BCL2L1/CD4/BST2/RELA/CCR5/GNG7/RPS6KB1/FBXW11/PPP3R1/CGAS/GNB1/CHEK1/PPP3CC/APOBEC3A/AKT3	5.98332268082087
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	37/1161	122/9376	2.44921704014346	NFKBIA/LCP2/PIK3CB/NFKB1/MAP3K8/PIK3R1/MAPK13/MALT1/TNF/MAP2K1/NFKBIE/NFATC1/PPP2CA/NFKBIB/CDC42/MAPK8/GSK3B/RAF1/PPP2R2D/GRB2/CSF2/KRAS/PPP2R3C/IL10/VAV3/BCL10/CD4/VAV2/SOS2/RELA/PPP3R1/RHOA/PPP2R5A/PPP3CC/CBLB/PPP2R3A/AKT3	6.05684645061824
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	28/1161	82/9376	2.75758912627886	HLA-DRA/CTSS/HLA-DRB5/CD74/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/HSPA5/HLA-DMA/HLA-DQA2/HLA-E/HLA-F/HLA-B/IFI30/TNF/HLA-DMB/PDIA3/HLA-A/HSP90AB1/HSPA6/HLA-DOA/CD4/NFYC/CANX/CTSL/CIITA	6.00925887253008
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	22/1161	56/9376	3.17263442844838	NFKBIA/CXCL8/CXCL2/NFKB1/IL1B/NFKB2/CXCL3/TNF/CLK1/ARF1/CASP1/IL18/CYCS/ITGB2/TLR2/CASP3/HSPA6/RELA/C3/HBS1L/ITGAM/RAB1A	6.13014403316392
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	28/1161	83/9376	2.72436516090201	EZH2/UBE2D1/JARID2/RYBP/CREBBP/PHF19/ASXL1/OGT/USP16/USP7/TEX10/RNF2/UBE2D3/FBRS/FBRSL1/LCOR/EP300/YAF2/FOXK2/L3MBTL4/SCML1/BCOR/EED/MTF2/SFMBT2/PHF1/RBBP4/PCGF5	5.93182433803207
Human Diseases	Infectious disease: viral	hsa05162	Measles	38/1161	136/9376	2.25647261488575	NFKBIA/PIK3CB/NFKB1/IL1B/TNFAIP3/TRAF3/PIK3R1/BCL2/BID/MSN/TBK1/TAB2/IFIH1/STAT5A/IRAK1/IRF7/CYCS/IL1A/NFKBIB/TLR2/MAPK8/GSK3B/IFNAR2/FAS/JAK1/OAS2/CASP3/BCL2L1/HSPA6/MX2/SLAMF1/ADAR/RELA/FCGR2B/MX1/CBLB/AKT3/IL2RA	5.548613321666
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	20/1161	50/9376	3.23031869078381	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DMA/HLA-DQA2/CXCR4/HLA-DMB/IL15/TNFSF13/CD86/CD40/IL10/HLA-DOA/CD80/TGFB1/ITGA4	5.94432005481847
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	47/1161	187/9376	2.02974570142833	NFKBIA/CXCL8/ERBIN/CXCL2/NFKB1/IL1B/TNFAIP3/TANK/CXCL3/BIRC2/TRAF3/MAPK13/BCL2/TNF/GBP2/RIPK1/MAP1LC3B/TBK1/TAB2/CASP1/IL18/IRF7/GABARAPL1/ITPR1/TICAM1/NLRP3/RIPK2/NFKBIB/PRKCD/CARD18/MAPK8/TXN/P2RX7/BIRC3/IFNAR2/GPSM3/HSP90AB1/JAK1/OAS2/ATG12/CARD16/BCL2L1/ATG5/RELA/RHOA/CCL5/NOD2	5.34705473048464
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	50/1161	204/9376	1.97936194288223	PIK3CB/TIAM1/CD44/RDX/PLAUR/PIK3R1/CDKN1A/PRKCB/MAPK13/DDX5/BRAF/TNF/MAP2K1/SRC/CTNNB1/PLCG2/MSN/MRAS/ITGAV/HBEGF/SDC2/PDCD4/IQGAP1/SMAD2/ITPR1/MMP9/CDC42/TLR2/RAF1/PPP1R12A/GRB2/FAS/EZR/KRAS/SLC9A1/HCLS1/CASP3/VAV3/VAV2/PLAU/SOS2/EIF4B/RPS6KB1/TGFB1/RHOA/CTSL/THBS1/AKT3/MYC/MET	5.31648078516107
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	37/1161	133/9376	2.24665021727445	SOD2/PIK3CB/SGK1/CREBBP/PRKAG2/GADD45B/PIK3R1/CDKN1A/IRS2/MAPK13/SIRT1/BRAF/PLK3/MAP2K1/FOXO3/GADD45A/USP7/GABARAPL1/GADD45G/BCL6/MAPK8/BCL2L11/RAF1/GRB2/KRAS/EP300/ATG12/PLK2/IL10/SOS2/STK4/IL7R/TGFB1/PTEN/FOXO1/AKT3/CDKN2B	5.44329567195713
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	37/1161	133/9376	2.24665021727445	LCP2/PIK3CB/TYROBP/HLA-E/PIK3R1/PRKCB/HLA-B/BRAF/TNF/BID/MAP2K1/CD48/PLCG2/NFATC1/ICAM1/SYK/ITGB2/HLA-A/RAF1/FCER1G/SH3BP2/PTK2B/IFNAR2/GRB2/FAS/CSF2/KRAS/CASP3/TNFRSF10B/VAV3/IFNGR1/LAT2/VAV2/SOS2/PPP3R1/PPP3CC/FCGR3A	5.44329567195713
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	24/1161	69/9376	2.80897277459461	MAP2K3/LCP2/PIK3CB/PIK3R1/MAPK13/TNF/MAP2K1/PLCG2/SYK/MAPK8/RAF1/FCER1G/GRB2/ALOX5AP/CSF2/KRAS/GAB2/VAV3/VAV2/SOS2/ALOX5/AKT3/LYN/MAP2K4	5.66956427624077
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	39/1161	144/9376	2.18719494688487	NFKBIA/CXCL8/MAP2K3/CXCL2/NFKB1/IL1B/CXCL3/TCF7L2/PRKAG2/TRAF3/MAPK13/SIRT1/TNF/MAP3K5/RIPK1/CTNNB1/FOXO3/C5AR1/TBK1/TAB2/IRAK1/TRA2A/TRA2B/TICAM1/MAPK8/GSK3B/TCF7/FAS/CASP3/LY96/ACOX3/CAMKK2/RELA/ADIPOR2/C3/ALDH9A1/FOXO1/AKT3/MAP2K4	5.39701160303309
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	30/1161	98/9376	2.47218267151822	PIK3CB/ASAP1/FCGR2A/SPHK1/PIK3R1/MARCKS/PRKCB/MAP2K1/PLCG2/SYK/ACTR3/PRKCD/CDC42/RAF1/HCK/PRKCE/FCGR1A/GAB2/VAV3/PLA2G6/VAV2/ARPC5/BIN1/RPS6KB1/VASP/FCGR2B/WAS/FCGR3A/AKT3/LYN	5.50738604067011
Human Diseases	Immune disease	hsa05310	Asthma	15/1161	32/9376	3.78552971576227	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DMA/HLA-DQA2/TNF/HLA-DMB/FCER1G/CD40/IL10/HLA-DOA	5.93354628275342
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	35/1161	125/9376	2.26122308354867	PIK3CB/NFKB1/SPHK1/NSMAF/PIK3R1/SGMS2/PRKCB/MAPK13/BCL2/TNF/BID/SGPP2/MAP3K5/MAP2K1/GNA13/PPP2CA/GNA12/MAPK8/RAF1/GNAI3/PPP2R2D/FCER1G/KRAS/PRKCE/PPP2R3C/GAB2/RELA/CTSD/ASAH1/RHOA/PTEN/PPP2R5A/CERS6/PPP2R3A/AKT3	5.33642660918315
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	20/1161	54/9376	2.99103582479982	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DMA/HLA-DQA2/HLA-E/HLA-F/HLA-B/HLA-DMB/HLA-A/CD86/CD40/FAS/IL10/HLA-DOA/CD80	5.51593791339833
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	21/1161	59/9376	2.87443612315508	PIK3CB/TCF7L2/GADD45B/PIK3R1/CDKN1A/BRAF/MAP2K1/CTNNB1/FOXO3/GADD45A/GADD45G/GSK3B/TCF7/RAF1/GRB2/KRAS/DDB2/SOS2/PTEN/AKT3/MYC	5.42945911852108
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	24/1161	73/9376	2.65505645817847	PIK3CB/GADD45B/PIK3R1/CDKN1A/PRKCB/BRAF/MAP2K1/PLCG2/FOXO3/GADD45A/STAT5A/GADD45G/RAF1/RASSF5/GRB2/KRAS/EML4/DDB2/KIF5B/SOS2/STK4/TGFA/AKT3/MET	5.33655140302063
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	25/1161	78/9376	2.588396386846	CXCL8/NFKB1/IL1B/MAPK13/IRF8/TNF/CASP1/IRF1/IRAK1/CALM1/ITGB2/TICAM1/IL1A/NLRP3/MAPK8/GNAI3/CASP3/LY96/IL10/RELA/C3/RHOA/ITGAM/IL23A/TICAM2	5.29552941928474
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	48/1161	201/9376	1.92854847210974	TRAF1/CXCL8/BCL2A1/REL/NFKB1/DOT1L/CDK14/BIRC2/GADD45B/CDKN1A/ID2/DDX5/KDM6A/EWSR1/FUS/GADD45A/NFKBIZ/GADD45G/SPI1/MMP9/DDIT3/RARA/BCL6/PBX3/CD86/BIRC3/CD40/CSF2/FCGR1A/BCL2L1/DDB2/CCNT2/SUPT3H/PRCC/PLAU/RELA/SIN3A/CEBPA/JMJD1C/RUNX1/ITGAM/PPARG/FOXO1/MYC/ETV6/ATF1/PAX8/MET	5.00262024314731
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	30/1161	103/9376	2.35217380396879	NFKBIA/CXCL8/PIK3CB/NFKB1/CCL3/IL1B/CFLAR/CCL3L1/PIK3R1/MAPK13/TNF/IRAK1/SMAD2/TICAM1/PPP2CA/TLR2/MAPK8/GNAI3/PPP2R2D/FAS/GNA15/IL10/GNAL/IFNGR1/RELA/C3/TGFB1/CCL5/AKT3/MAP2K4	5.18727132333837
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	56/1161	250/9376	1.80897846683893	ARFGAP3/ASAP1/RAB7A/CHMP4B/EHD1/CHMP1B/HLA-E/ZFYVE16/HLA-F/HLA-B/NEDD4L/RAB5A/IGF2R/SMAP2/CXCR4/SRC/RAB11A/AGAP3/ARF1/CYTH1/CHMP2B/VPS4B/SMAD2/IST1/PDCD6IP/HLA-A/ACTR3/CDC42/WASL/ARRB2/RAB35/VPS37B/SMURF2/WASHC2A/HSPA6/STAM/KIF5B/ARPC5/ARFGEF1/SMAP1/RAB8A/SMURF1/BIN1/EEA1/CCR5/TFRC/RHOA/EHD4/CBLB/PSD/ARFGAP2/IQSEC1/RAB11FIP1/PSD4/ACAP2/IL2RA	4.87376627161415
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	25/1161	80/9376	2.52368647717485	PIK3CB/IL6R/EIF4E/PIK3R1/PRKCB/BRAF/BCL2/MAP2K1/SRC/PLCG2/FOXO3/BCL2L11/GSK3B/RAF1/GRB2/KRAS/JAK1/BCL2L1/SOS2/PDGFC/RPS6KB1/PTEN/TGFA/AKT3/MET	5.14506082454718
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	27/1161	90/9376	2.42273901808786	SOD2/PIK3CB/NFKB1/RB1CC1/PRKAG2/ATF4/EIF4E/PIK3R1/IRS2/RHEB/SIRT1/ADCY3/FOXO3/RPTOR/ATF2/KRAS/ATG13/ADCY9/SESN2/ATG5/CAMKK2/RELA/ADIPOR2/RPS6KB1/PPARG/FOXO1/AKT3	5.09835557563461
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	29/1161	101/9376	2.31879311962204	CXCL8/PIK3CB/NFKB1/IL1B/PIK3R1/PRKCB/MAPK13/BCL2/TNF/PLCG2/NFATC1/STAT5A/ICAM1/SMAD2/IL1A/PRKCD/CDC42/MAPK8/PIM1/KRAS/PRKCE/CASP3/RELA/TGFB1/THBD/F3/FOXO1/AKT3/EDN1	5.00931525830462
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	24/1161	77/9376	2.51713144736401	PIK3CB/NFKB1/GADD45B/PIK3R1/CDKN1A/BRAF/MAP2K1/GADD45A/SMAD2/GADD45G/RALGDS/CDC42/MAPK8/RAF1/KRAS/JAK1/BCL2L1/DDB2/RELA/RPS6KB1/TGFB1/BRCA2/TGFA/AKT3	5.02514286748184
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	24/1161	77/9376	2.51713144736401	NFKBIA/PIK3CB/NFKB1/GADD45B/PIK3R1/CDKN1A/BRAF/MAP2K1/GADD45A/STAT5A/GADD45G/RAF1/CTBP2/GRB2/KRAS/BCL2L1/GAB2/DDB2/SOS2/RELA/RUNX1/TGFB1/AKT3/MYC	5.02514286748184
NA	NA	hsa04517	IgSF CAM signaling	63/1161	299/9376	1.70158927691789	TJP2/LCP2/PIK3CB/ITGAX/RAPGEF2/RDX/PIK3R1/PRKCB/MAPK13/EPB41L3/CD84/SLAMF7/MAP2K1/NRP2/SRC/CTNNB1/CD48/PLCG2/MSN/MBP/PPFIA1/SRGAP1/ICAM1/IQGAP1/RAP1B/CADM1/ITGB2/ACTR3/TUBB4B/CDC42/WASL/MAPK8/SRGAP3/GSK3B/CD226/EPB41L2/CD86/GRB2/EZR/MTSS1/TRIO/RAPGEF6/PVR/TUBA1C/NPHS1/NRP1/RAP1A/TUBB6/SLAMF1/VAV3/VAV2/ARPC5/CD80/MYH9/CABLES2/PMP22/RHOA/ITGAM/JAML/FOXO1/AKT3/ITGA4/LYN	4.63495298581762
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	39/1161	157/9376	2.0060896328116	GPR132/ABCA1/RAB7A/DUSP2/MAPKAPK2/PTGS2/SPHK1/SGK1/MAPK13/SIRT1/RAB5A/PTGER4/ATP2A2/DUSP5/MAP2K1/SIRPA/DUSP16/ITGAV/NFATC1/CASP1/ANO6/ATP11B/ADAM17/HAVCR2/PTGER2/ATP11C/CASP3/LIPA/IL10/PLA2G6/ATP8A1/TGFB1/NR1H3/PPARD/THBS1/ALOX5/PPARG/SLC16A1/ATP11A	4.779060811452
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	15/1161	37/9376	3.27397164606467	TCF7L2/GADD45B/CDKN1A/BRAF/MAP2K1/CTNNB1/GADD45A/GADD45G/TCF7/KRAS/DDB2/NCOA4/PPARG/MYC/PAX8	5.2099515395985
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	26/1161	90/9376	2.33300794334386	NFKBIA/MAP2K3/PIK3CB/NFKB1/PIK3R1/MAPK13/MAP2K1/NFKBIE/NFATC1/TICAM1/NFKBIB/TLR2/RAF1/KRAS/JAK1/EML4/IFNGR1/CD4/RELA/CD274/RPS6KB1/PPP3R1/PTEN/PPP3CC/AKT3/TICAM2	4.77680614217381
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	22/1161	70/9376	2.53810754275871	PIK3CB/RAPGEF1/CREBBP/PIK3R1/CDKN1A/BRAF/MAP2K1/RAP1B/ELOC/CDC42/RAF1/GRB2/KRAS/EP300/RAP1A/FH/PRCC/SOS2/TGFB1/TGFA/AKT3/MET	4.85570352357656
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	52/1161	238/9376	1.76445978908359	NFKBIA/CXCL8/PIK3CB/NFKB1/IL1B/FCGR2A/IL6R/TRAF3/PIK3R1/PRKCB/MAPK13/TNF/RPS20/PLCG2/C5AR1/TBK1/TAB2/CASP1/IFIH1/HBEGF/IRAK1/SYK/ADAM17/NLRP3/NFKBIB/TLR2/RPL36AL/MAPK8/RPS27/RPL21/RPL22L1/IFNAR2/CSF2/RPL36A/JAK1/OAS2/NRP1/MX2/RPL13A/RPL23/ADAR/RELA/CGAS/RPS17/RPS9/C3/MX1/RPL9/RPL30/RPS29/RPL38/RPL31	4.49071518998112
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	22/1161	71/9376	2.50235954919872	NFKBIA/CXCL8/ATP6V1H/CXCL2/NFKB1/CXCL3/MAPK13/SRC/PLCG2/HBEGF/ATP6V0D1/ADAM17/CDC42/ATP6V1F/MAPK8/ATP6V1B2/CASP3/RELA/CCL5/LYN/MAP2K4/MET	4.77686350201449
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	22/1161	72/9376	2.46760455545985	NFKBIA/CXCL8/NFKB1/TANK/CYLD/TRAF3/MAPK13/ZNFX1/TNF/RIPK1/TBK1/IFIH1/IRF7/DDX3X/NFKBIB/MAPK8/TRIM25/ATG12/ATG5/ADAR/RELA/MAP3K1	4.69935671855246
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	46/1161	205/9376	1.81212999726897	NFKBIA/TRAF1/REL/PIK3CB/NFKB1/NFKB2/MAPKAPK2/CREBBP/HLA-E/ATF4/PMAIP1/TRAF3/PIK3R1/CDKN1A/HLA-F/HLA-B/MAD1L1/SRC/USP7/STAT5A/ATP6V0D1/IRF7/HDAC9/DDX3X/SYK/HLA-A/CDC42/GTF2B/ATF2/GRB2/KRAS/EP300/JAK1/GTF2A1/UBR4/CASP3/SNW1/RELA/CCR5/C3/RHOA/SND1/GTF2H1/CHEK1/CDKN2B/LYN	4.41969296545135
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	37/1161	156/9376	1.91541332626604	NFKBIA/PIK3CB/NFKB1/CFLAR/TRAF3/PIK3R1/CDKN1A/BRAF/TNF/BID/MAP2K1/RIPK1/CTNNB1/TBK1/IRF7/CYCS/RSAD2/TICAM1/PPP2CA/GSK3B/RAF1/PPP2R2D/PIAS1/IFNAR2/GRB2/FAS/KRAS/JAK1/OAS2/CASP3/MX2/SOS2/RELA/MX1/NR1H3/AKT3/MYC	4.3342307927733
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	28/1161	106/9376	2.13322932410251	NFKBIA/PIK3CB/NFKB1/CREBBP/TCF7L2/ATF4/PIK3R1/CDKN1A/BRAF/BCL2/MAP2K1/CTNNB1/MMP9/GSK3B/TCF7/RAF1/GRB2/KRAS/HSP90AB1/EP300/PLAU/SOS2/PDGFC/RELA/PTEN/TGFA/FOXO1/AKT3	4.4109164722323
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	24/1161	86/9376	2.25371071450033	EREG/PIK3CB/ABL2/PIK3R1/CDKN1A/PRKCB/BRAF/MAP2K1/SRC/PLCG2/HBEGF/STAT5A/MAPK8/GSK3B/RAF1/GRB2/KRAS/SOS2/RPS6KB1/TGFA/CBLB/AKT3/MYC/MAP2K4	4.3907293781982
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	44/1161	200/9376	1.77667527993109	NFKBIA/CXCL8/NFKB1/IL1B/FCGR2A/ABI1/ARHGEF2/MAPK13/TNF/SRC/RIPK1/TAB2/ARF1/CASP1/CYTH1/IL1R1/NCL/IRAK1/IL18/GNA13/CYCS/ACTR3/NLRP3/GNA12/CYFIP1/TUBB4B/NFKBIB/CDC42/WASL/MAPK8/FAS/EZR/HCLS1/TUBA1C/CASP3/TNFRSF10B/TUBB6/ARPC5/RELA/MYH9/MYO1G/RHOA/MYO1E/RAB1A	4.17374337006306
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	25/1161	93/9376	2.17091309864503	NFKBIA/TRAF1/PIK3CB/NFKB1/PTGS2/BIRC2/GADD45B/TRAF3/PIK3R1/CDKN1A/BCL2/ITGAV/GADD45A/GADD45G/CYCS/BIRC3/CKS2/CASP3/BCL2L1/DDB2/RELA/PTEN/AKT3/MYC/CDKN2B	4.26599092830903
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	25/1161	94/9376	2.14781827844668	NFKBIA/CXCL8/MAPK6/CXCL2/NFKB1/IL1B/TNFAIP3/PTGS2/CXCL3/CCL20/TRAF3/MAPK13/TNF/TBK1/TAB2/FOSL1/MMP9/MAPK8/GSK3B/S100A8/CSF2/HSP90AB1/S100A9/CASP3/RELA	4.20449892073758
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	45/1161	212/9376	1.71420213543952	DOCK4/MAP2K3/LCP2/PIK3CB/RASGRP3/TIAM1/RAPGEF2/RAPGEF1/PIK3R1/PRKCB/MAPK13/BRAF/ADCY3/MAP2K1/SRC/CTNNB1/MRAS/CALM1/RAP1B/ADORA2A/ITGB2/RALGDS/CDC42/FPR1/RAF1/GNAI3/RASSF5/KRAS/RAPGEF6/ADCY9/ADORA2B/RAP1A/VAV3/SIPA1L2/VAV2/PDGFC/FYB1/VASP/APBB1IP/RHOA/ITGAM/P2RY1/THBS1/AKT3/MET	3.9540713228214
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	36/1161	158/9376	1.84005495044647	FNIP2/ATP6V1H/PIK3CB/SLC7A5/SGK1/EIF4E/RPS6KA3/PIK3R1/PRKCB/RHEB/BRAF/TNF/MAP2K1/RPTOR/RRAGD/ATP6V1F/GSK3B/RAF1/ATP6V1B2/MAPKAP1/GRB2/FNIP1/KRAS/SESN2/RRAGC/TBC1D7/DEPDC5/SOS2/EIF4B/WDR59/LAMTOR3/RPS6KB1/ULK2/RHOA/PTEN/AKT3	4.00327893399093
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	33/1161	142/9376	1.87676966189904	PIK3CB/NFKB1/IL1B/NFE2L2/PIK3R1/ARHGEF2/MAPK13/BCL2/TNF/MAP3K5/SRC/CTNNB1/NCF2/ITGAV/IL1R1/ICAM1/SDC2/CALM1/MMP9/IL1A/MAPK8/TXN/HSP90AB1/ACVR2A/RELA/THBD/RHOA/CTSL/MEF2A/GSTO2/AKT3/EDN1/MAP2K4	3.95760745234609
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	36/1161	160/9376	1.81705426356589	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/CD58/ALCAM/ITGB8/HLA-DMA/HLA-DQA2/HLA-E/HLA-F/HLA-B/ITGAV/HLA-DMB/ICAM1/SDC2/CADM1/ITGB2/HLA-A/CD22/CD226/CD86/CD40/PVR/HLA-DOA/CD4/CD80/CD274/SIGLEC1/ITGAM/JAML/ITGA4/VSIR	3.9186603538513
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	26/1161	103/9376	2.03855063010629	PABPC1/PABPC4/NXF1/WDR33/ETF1/SMG1/PCF11/FUS/RBM8A/PNN/EIF4A3/SRRM1/PPP2CA/CPSF7/PPP2R2D/UPF3B/PPP2R3C/RNMT/NXT2/WDR82/PAPOLA/GSPT1/HBS1L/PPP2R5A/PPP2R3A/SAP18	3.98413568253809
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	14/1161	41/9376	2.75758912627886	CXCL8/CDKN1A/BRAF/MAP2K1/SRC/HBEGF/MMP9/RAF1/DAPK1/KRAS/TYMP/THBS1/MYC/RPS6KA5	4.23984605914315
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	27/1161	110/9376	1.98224101479915	SMAD7/CREBBP/ZFYVE16/ID2/CUL1/TNF/SKIL/SMAD2/PPP2CA/TGIF1/EMP3/TGIF2/SMURF2/EP300/ACVR2A/SMURF1/LEMD3/SIN3A/RPS6KB1/TFRC/SKI/TGFB1/RHOA/HAMP/THBS1/MYC/CDKN2B	3.89552704263959
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	20/1161	73/9376	2.21254704848206	CHMP4B/CREBBP/ELL2/CXCR4/VPS4B/PDCD6IP/CPSF7/EP300/MX2/CCNT2/CD4/ELL/NUP153/MDFIC/BST2/CCR5/TNPO3/AFF4/MX1/APOBEC3A	3.90972744212433
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	62/1161	333/9376	1.50360179300748	ATP6V1H/PIK3CB/NFKB1/NOTCH2/PTGS2/ITGB8/CREBBP/TCF7L2/HLA-E/TRAF3/PIK3R1/CDKN1A/HLA-F/HLA-B/RHEB/PTGER4/TNF/MAP2K1/PSEN1/CTNNB1/TBK1/ITGAV/IRF1/ATP6V0D1/HLA-A/TICAM1/PPP2CA/CDC42/ATP6V1F/GSK3B/TCF7/RAF1/PPP2R2D/ATP6V1B2/IFNAR2/GRB2/FAS/OASL/NOTCH1/KRAS/MAML1/EP300/JAK1/UBR4/CASP3/PPP2R3C/HES4/MX2/HES1/SOS2/CSNK1A1/RELA/RPS6KB1/LFNG/MX1/PTEN/PPP2R5A/THBS1/PPP2R3A/FOXO1/AKT3/ITGA4	3.51763750601203
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	20/1161	75/9376	2.15354579385587	GADD45B/PMAIP1/CDKN1A/BCL2/BID/GADD45A/ZNF385A/GADD45G/CYCS/COP1/FAS/SESN2/CASP3/TNFRSF10B/BCL2L1/DDB2/SIAH1/PTEN/CHEK1/THBS1	3.77049712228375
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	36/1161	168/9376	1.73052787006275	PIK3CB/IL3RA/CSF2RA/IL6R/CREBBP/PIK3R1/CDKN1A/BCL2/IL10RA/CSF3R/IL4R/STAT5A/STAT4/IL15/CLCF1/RAF1/PTPN2/PIAS1/PIM1/IFNAR2/GRB2/CSF2/MCL1/EP300/JAK1/BCL2L1/OSM/IL10/STAM/IFNGR1/SOS2/IL7R/IL23A/AKT3/MYC/IL2RA	3.59175528038683
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	27/1161	115/9376	1.89605662285136	SGK1/AKAP13/ATF4/CDKN1A/PRKCB/BRAF/BCL2/ADCY3/MAP2K1/HBEGF/GNA13/MAFB/ITPR1/GNA12/PDE4B/RAF1/GNAI3/ARRB2/ATF2/ADCY9/OXSR1/MEF2D/NR4A2/PDE4A/VDR/RHOA/MEF2A	3.63457300267932
Human Diseases	Cancer: specific types	hsa05214	Glioma	20/1161	76/9376	2.12520966498935	PIK3CB/GADD45B/PIK3R1/CDKN1A/PRKCB/BRAF/MAP2K1/PLCG2/GADD45A/CALM1/GADD45G/RAF1/GRB2/KRAS/DDB2/SOS2/PTEN/TGFA/CAMK1D/AKT3	3.70251426063764
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	23/1161	93/9376	1.99724005075343	MAP2K3/ATF4/PRKCB/MAPK13/ADCY3/MAP2K1/SRC/HBEGF/CALM1/ITPR1/PRKCD/CDC42/MAPK8/RAF1/MAP3K2/PTK2B/GRB2/KRAS/ADCY9/SOS2/MAP3K4/MAP3K1/MAP2K4	3.63324743295083
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	28/1161	122/9376	1.85346154389235	MAP2K3/PIK3CB/CREBBP/ATF4/PIK3R1/IRS2/PRKCB/MAPK13/ADCY3/MAP2K1/PLCG2/STAT5A/SSTR2/ITPR1/MAPK8/GSK3B/RAF1/GNAI3/ATF2/GRB2/KRAS/EP300/ADCY9/SOS2/ADCY10/MAP3K1/AKT3/MAP2K4	3.56695055307369
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	31/1161	142/9376	1.76302604602637	UBE2D1/UBE2H/UBC/BIRC2/NEDD4L/UBE2J1/CUL1/UBE2R2/UBE2E2/CUL3/UBE2N/UBR5/ELOC/COP1/UBE2D3/UBE2A/UBE2E1/PIAS1/BIRC3/SMURF2/UBE2S/TRIP12/DDB2/SIAH1/FZR1/SMURF1/UBE2I/FBXW11/MAP3K1/CBLB/UBE2Q2	3.44418573921398
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	29/1161	130/9376	1.80152388524482	NFKBIA/PIK3CB/NFKB1/ATF4/PIK3R1/MAPK13/ADCY3/MAP2K1/SRC/SMAD2/MMP9/MAPK8/RAF1/GNAI3/ARRB2/ATF2/GRB2/GNG5/KRAS/GNA15/ADCY9/SOS2/RELA/GNG7/GNB1/TGFB1/AKT3/EDN1/MAP2K4	3.45946677973208
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	17/1161	62/9376	2.21433136061793	NCOR2/NOTCH2/CREBBP/PSEN1/ADAM17/TLE4/CTBP2/NOTCH1/MAML1/EP300/SNW1/SPEN/HES1/APH1B/LFNG/TLE3/NUMB	3.60630872949002
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	36/1161	174/9376	1.670854495233	PPP1R15A/DNAJC3/UBE2D1/NFE2L2/HSPA5/ATF4/DNAJB11/EIF2AK3/XBP1/UBE2J1/CUL1/BCL2/ERO1B/STT3B/MAP3K5/ERN1/EDEM1/HERPUD1/PDIA3/DDIT3/UBE2D3/MAPK8/CAPN2/HYOU1/NGLY1/HSP90AB1/ATF6/SELENOS/MAGT1/SEL1L/UBXN1/HSPA6/CANX/DNAJB1/DNAJA1/SEL1L2	3.35783852928315
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	33/1161	157/9376	1.69746045853289	CXCL8/PIK3CB/NFKB1/IL1B/IL6R/PRKAG2/ATF4/PIK3R1/EIF2AK3/IRS2/XBP1/MAPK13/TNF/BID/MAP3K5/ERN1/CYCS/IL1A/DDIT3/CDC42/MAPK8/BCL2L11/GSK3B/FAS/UQCRC2/CASP3/RELA/ADIPOR2/CEBPA/TGFB1/NR1H3/PPARG/AKT3	3.31303080382309
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	24/1161	103/9376	1.88173904317503	CXCL8/CXCL2/PIK3CB/NFKB1/SERPINB9/IL1B/RAB7A/CXCL3/PIK3R1/PRKCB/RAB5A/TNF/IL1R1/SERPINB10/ITGB2/TLR2/CSF2/GNA15/CASP3/IL10/GNAL/RELA/TGFB1/ITGAM	3.38256786213796
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	26/1161	116/9376	1.81009236983575	PIK3CB/PIK3R1/PRKCB/MAPK13/CXCR4/CTNNB1/PLCG2/MSN/NCF2/ICAM1/RAP1B/ITGB2/MMP9/CDC42/RHOH/GNAI3/PTK2B/RASSF5/EZR/RAP1A/VAV3/VAV2/VASP/RHOA/ITGAM/ITGA4	3.30031966440498
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	27/1161	122/9376	1.78726648875334	PIK3CB/NOTCH2/CREBBP/MED13/PIK3R1/PRKCB/RHEB/ATP2A2/MED13L/ATP1B3/MAP2K1/SRC/CTNNB1/PLCG2/ITGAV/GSK3B/RAF1/NOTCH1/KRAS/SLC9A1/EP300/ATP1A1/SIN3A/FOXO1/AKT3/MYC/MED14	3.29029545334652
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	23/1161	99/9376	1.87619519919262	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/FCGR2A/HLA-DMA/HLA-DQA2/C5AR1/HLA-DMB/ICAM1/ITGB2/FPR1/FPR3/FCGR1A/IL10/HLA-DOA/C3/FCGR2B/ITGAM/FCGR3A	3.29467554605186
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	34/1161	166/9376	1.6540788476905	PIK3R5/ATP2B1/ATF4/IRS2/PPIF/ADCY3/ATP2A2/ATP1B3/MAP2K1/ADRB2/NFATC1/GNA13/CALM1/ITPR1/GNA12/RGS2/RAF1/GNAI3/PPP1R12A/ATF2/KCNMA1/PRKCE/ADCY9/MEF2D/SLC8A1/ATP1A1/KCNMB4/VASP/PPP3R1/RHOA/PPP3CC/MEF2A/AKT3/PIK3CG	3.19633505458693
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	16/1161	60/9376	2.15354579385587	PIK3CB/MAPKAPK2/PTGS2/SPHK1/PIK3R1/PRKCB/MAPK13/MAP2K1/SRC/PLCG2/CDC42/RAF1/KRAS/PPP3R1/PPP3CC/AKT3	3.36971902124653
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	18/1161	71/9376	2.04738508570805	PIK3CB/NFKB1/PIK3R1/MAPK13/MAP2K1/SRC/FOXO3/IRF1/STAT5A/TNFRSF11A/MAPK8/GSK3B/RAF1/GRB2/KRAS/SOS2/RELA/AKT3	3.33023848461677
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	23/1161	100/9376	1.85743324720069	CXCL8/CXCL2/CCL3/IL6R/CCL3L1/CXCL3/CCL20/TNF/IL10RA/CXCR4/CCR7/IL18/TNFRSF1B/CCL4/TNFRSF14/TNFRSF10D/TNFRSF10B/IL10/CCR5/TNFSF14/CCL5/CCR1/IL2RA	3.24054393224555
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	29/1161	138/9376	1.69708771798425	PIK3CB/RAPGEF1/PRKAG2/EIF4E/PIK3R1/IRS2/RHEB/BRAF/MAP2K1/RPTOR/CALM1/PTPN1/HK2/MAPK8/GSK3B/RAF1/GRB2/INPP5A/TRIP10/KRAS/RHOQ/FBP1/FLOT1/SOS2/RPS6KB1/MKNK2/CBLB/FOXO1/AKT3	3.10124415947831
Organismal Systems	Immune system	hsa04611	Platelet activation	27/1161	126/9376	1.73052787006275	PIK3R5/LCP2/PIK3CB/FCGR2A/PIK3R1/MAPK13/ADCY3/SRC/PLCG2/GNA13/RAP1B/SYK/ITPR1/GNAI3/PPP1R12A/FCER1G/TBXAS1/ADCY9/RAP1A/FERMT3/VASP/APBB1IP/RHOA/P2RY1/AKT3/LYN/PIK3CG	3.10348149047386
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	16/1161	62/9376	2.08407657469923	SOD2/PIK3CB/PRKAG2/PIK3R1/IRS2/SIRT1/ADCY3/FOXO3/RPTOR/KRAS/ADCY9/HSPA6/ATG5/RPS6KB1/FOXO1/AKT3	3.21947941193255
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	34/1161	170/9376	1.6151593453919	TJP2/TIAM1/RAPGEF2/RDX/PRKAG2/ARHGEF2/NEDD4L/RAP2C/MAP3K5/SRC/MSN/RAB8B/WHAMM/ACTR3/PPP2CA/CDC42/MAPK8/PPP2R2D/EZR/PRKCE/RAPGEF6/HCLS1/TUBA1C/RAP1A/ARPC5/MYH9/RAB8A/VASP/MICALL2/RUNX1/RHOA/YBX3/MAP3K1/WAS	3.04280811421683
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	34/1161	170/9376	1.6151593453919	PIK3CB/NFE2L2/TCF7L2/GADD45B/PIK3R1/CDKN1A/PRKCB/BRAF/MAP2K1/CTNNB1/PLCG2/GADD45A/SMAD2/GADD45G/TXNRD1/ARID2/GSK3B/TCF7/RAF1/GRB2/KRAS/BCL2L1/PHF10/DDB2/SOS2/CSNK1A1/RPS6KB1/TGFB1/PTEN/GSTO2/TGFA/AKT3/MYC/MET	3.04280811421683
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	53/1161	298/9376	1.43629941788206	CXCL8/CXCL2/CCL3/IL3RA/IL1B/CSF2RA/IL6R/CCL3L1/CXCL3/CCL20/IL1RN/RELT/TNF/IL10RA/CXCR4/CCR7/CXCL16/CSF3R/IL4R/IL1R1/IL18/IL15/CLCF1/TNFRSF1B/CCL4/TNFRSF14/IL1A/TNFRSF11A/TNFSF13/CD40/IFNAR2/FAS/TNFRSF9/CSF2/TNFRSF10D/ACVR2A/TNFSF8/RELL1/TNFRSF10B/OSM/IL10/IFNGR1/CD4/CCR5/TNFSF14/IL7R/TGFB1/IL23A/IL1RL2/CCL5/EBI3/CCR1/IL2RA	2.8773695316258
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	12/1161	42/9376	2.307370493417	ACSL5/ACSL1/GCLC/ACSL3/MAP1LC3B/SLC11A2/SLC7A11/ATG5/NCOA4/SAT1/TFRC/PCBP2	3.19218013082732
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	10/1161	32/9376	2.52368647717485	BIRC2/PMAIP1/BCL2/BID/CYCS/MAPK8/BCL2L11/BIRC3/CASP3/BCL2L1	3.24565348614434
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	23/1161	105/9376	1.76898404495304	RABGEF1/RAB7A/UBC/ATF4/EIF2AK3/RAB5A/SRC/MAP1LC3B/FOXO3/MRAS/TBK1/ARIH1/GABARAPL1/USP15/TBC1D15/MAPK8/SMURF2/KRAS/CITED2/BCL2L1/SIAH1/RELA/SMURF1	2.97883640108801
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	18/1161	78/9376	1.86364539852912	BTG1/PABPC1/PABPC4/TENT4A/CNOT1/DCP2/BTG3/CNOT4/CNOT2/DDX6/DHX36/HSPA9/CNOT6L/TOB2/DIS3/CNOT6/TENT4B/PAN3	2.87929364081603
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	13/1161	50/9376	2.09970714900947	CXCL8/IL1B/TNF/IL18/ICAM1/SDC2/ITGB2/TLR2/CD40/IL10/TGFB1/THBS1/MET	2.9309763162084
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	28/1161	140/9376	1.6151593453919	PIK3R5/SPHK1/PRKAG2/ADCY3/MAP2K1/MAP1LC3B/MRAS/GNA13/CALM1/SMAD2/ITPR1/RAF1/GNAI3/GNG5/KRAS/SLC9A1/PRKCE/ADCY9/MEF2D/SLC8A1/GNG7/ADCY10/RPS6KB1/GNB1/NRF1/MEF2A/AKT3/PIK3CG	2.75681514526937
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	29/1161	149/9376	1.57179936296528	CXCL8/PIK3R5/PIK3CB/SPHK1/PIK3R1/RHEB/ADCY3/MAP2K1/PLCG2/MRAS/ARF1/CYTH1/GNA13/SYK/RALGDS/GNA12/RAF1/FCER1G/PTK2B/GRB2/KRAS/ADCY9/GAB2/SOS2/PDGFC/AGPAT4/RHOA/AKT3/PIK3CG	2.64487106395429
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	21/1161	99/9376	1.71304779056717	PIK3CB/NOTCH2/PIK3R1/CDKN1A/MAPK13/BRAF/BCL2/ADCY3/MAP2K1/SRC/HBEGF/MMP9/MAPK8/RAF1/GRB2/NOTCH1/KRAS/ADCY9/SOS2/RPS6KB1/AKT3	2.68120747627096
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	17/1161	75/9376	1.83051392477749	PIK3CB/BIRC2/PMAIP1/PIK3R1/CDKN1A/BCL2/BID/MAP3K5/REV3L/CYCS/BIRC3/FAS/CASP3/BCL2L1/MSH6/GSTO2/AKT3	2.71463029909099
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	16/1161	70/9376	1.8458963947336	NFKBIA/NFKB1/ACSL5/PRKAG2/ACSL1/IRS2/TNF/ACSL3/NFKBIE/TNFRSF1B/NFKBIB/MAPK8/CAMKK2/RELA/ADIPOR2/AKT3	2.6704388284331
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	60/1161	362/9376	1.33852984424743	PIK3R5/EREG/PIK3CB/NFKB1/IL3RA/IL6R/SGK1/ITGB8/ATF4/EIF4E/PIK3R1/CDKN1A/PHLPP1/RHEB/BCL2/MAP2K1/FOXO3/ITGAV/CSF3R/RPTOR/IL4R/SYK/PPP2CA/TLR2/BCL2L11/GSK3B/RAF1/PPP2R2D/ATF2/IFNAR2/GRB2/GNG5/KRAS/HSP90AB1/MCL1/JAK1/PPP2R3C/BCL2L1/OSM/PIK3AP1/NR4A1/SOS2/PDGFC/EIF4B/RELA/GNG7/RPS6KB1/GNB1/IL7R/PTEN/PPP2R5A/THBS1/TGFA/PPP2R3A/AKT3/ITGA4/MYC/PIK3CG/IL2RA/MET	2.46939425820509
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	18/1161	83/9376	1.751377603437	NFKBIA/NFKB1/IL1B/RIPK1/GSDME/TBK1/CASP1/IL18/IRF7/CCL4/NLRP3/NFKBIB/G3BP1/CASP3/ADAR/RELA/CGAS/CCL5	2.58474252216298
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	40/1161	226/9376	1.42934455344416	NFKBIA/PIK3CB/NFKB1/TIAM1/ATP2B1/CREBBP/PIK3R1/BRAF/ADCY3/ATP2A2/ATP1B3/MAP2K1/ADRB2/NFATC1/SSTR2/CALM1/RAP1B/ADORA2A/PDE4B/MAPK8/RAF1/GNAI3/PTGER2/PPP1R12A/SLC9A1/EP300/ADCY9/RAP1A/ACOX3/PDE4A/ATP1A1/VAV3/VAV2/RELA/HCAR3/ADCY10/RHOA/AKT3/EDN1/HCAR2	2.45610876322481
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	9/1161	32/9376	2.27131782945736	RPTOR/GABARAPL1/PPP2CA/ATG4B/ATG13/ATG12/ATG5/ATG3/ULK2	2.70807492682253
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	31/1161	168/9376	1.49017677699848	IL1B/CFLAR/TNFAIP3/CHMP4B/CYLD/BIRC2/CHMP1B/BCL2/TNF/BID/RIPK1/PPID/CASP1/STAT5A/CHMP2B/STAT4/VPS4B/TICAM1/IL1A/NLRP3/MAPK8/CAPN2/GLUL/BIRC3/IFNAR2/FAS/HSP90AB1/JAK1/TNFRSF10B/IFNGR1/TICAM2	2.41003129279114
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	22/1161	110/9376	1.6151593453919	PIK3CB/NFKB1/IL6R/CREBBP/EIF4E/PIK3R1/CDKN1A/PRKCB/BCL2/MAP2K1/PLCG2/ELOC/PFKFB3/HK2/EP300/IFNGR1/RELA/RPS6KB1/TFRC/MKNK2/AKT3/EDN1	2.43969639772844
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	13/1161	55/9376	1.9088246809177	GM2A/SPHK1/B4GALT5/SGMS2/SGPP2/PSAP/GLA/UGCG/ACER3/ASAH1/GALC/CERS6/NEU3	2.54113751399161
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	15/1161	67/9376	1.80801419260288	CREBBP/ATF4/RPS6KA3/PRKCB/BRAF/MAP2K1/CALM1/RAP1B/ITPR1/RAF1/KRAS/EP300/RAP1A/PPP3R1/PPP3CC	2.49518550878285
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	36/1161	203/9376	1.432160995914	PIK3CB/RAPGEF1/ITGB8/BIRC2/PIK3R1/PRKCB/BRAF/BCL2/MAP2K1/SRC/CTNNB1/ITGAV/RAP1B/CDC42/MAPK8/CAPN2/GSK3B/RAF1/PPP1R12A/BIRC3/GRB2/RAP1A/VAV3/VAV2/SOS2/PDGFC/PARVB/VASP/EMP1/RHOA/PTEN/THBS1/PARVG/AKT3/ITGA4/MET	2.34010774542062
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	13/1161	56/9376	1.87473852590132	CUL1/BCL2/CUL3/GSK3B/ARRB2/SPOPL/SMURF2/PTCH2/CSNK1A1/SMURF1/FBXW11/SCUBE2/CSNK1G1	2.46809729465721
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	20/1161	99/9376	1.63147408625445	MAP2K3/PIK3CB/IL1B/PIK3R1/PRKCB/MAPK13/PTGER4/ADCY3/SRC/PRKCH/PLCG2/IL1R1/CALM1/ITPR1/PRKCD/MAPK8/PTGER2/PRKCE/ADCY9/PLA2G6	2.37447344138051
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	19/1161	93/9376	1.64989395497022	CREBBP/TCF7L2/PTPRJ/SRC/CTNNB1/IQGAP1/RAP1B/PTPN1/CDC42/WASL/TCF7/SMURF2/EP300/FER/RAP1A/SMURF1/RHOA/WAS/MET	2.36776044223443
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	12/1161	52/9376	1.86364539852912	ABCA1/VAPA/APOE/NPC1/MYLIP/APOC1/SOAT1/LIPA/LPL/VAPB/APOC2/STARD3	2.34765333279943
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	27/1161	148/9376	1.4732872407291	PIK3CB/NOTCH2/NFKB2/TCF7L2/GADD45B/PIK3R1/CDKN1A/BRAF/MAP2K1/CTNNB1/GADD45A/GADD45G/GSK3B/TCF7/RAF1/GRB2/NOTCH1/KRAS/HES1/DDB2/SOS2/CSNK1A1/RPS6KB1/PTEN/BRCA2/AKT3/MYC	2.18172408242272
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	23/1161	122/9376	1.52248626819729	PIK3CB/PRKAG2/PIK3R1/IRS2/RHEB/SIRT1/FOXO3/TBC1D1/RPTOR/PFKFB3/PPP2CA/PPP2R2D/PPP2R3C/FBP1/CAMKK2/ADIPOR2/RAB8A/RPS6KB1/PPP2R5A/PPARG/PPP2R3A/FOXO1/AKT3	2.18367505443783
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	21/1161	109/9376	1.55588744280871	NFKBIA/PIK3CB/NFKB1/PRKAG2/RPS6KA3/PIK3R1/IRS2/PRKCB/TNF/OGT/PTPN1/PRKCD/MAPK8/GSK3B/PRKCE/RELA/RPS6KB1/PTEN/NR1H3/FOXO1/AKT3	2.19446417505934
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	40/1161	238/9376	1.35727676083353	REL/PIK3CB/ETS2/NFKB1/RASGRP3/TIAM1/ABL2/PIK3R1/PRKCB/RAB5A/SHOC2/MAP2K1/PLCG2/MRAS/TBK1/CALM1/RAP1B/RALGDS/CDC42/MAPK8/RAF1/RASSF5/GRB2/GNG5/KRAS/RAP1A/BCL2L1/GAB2/PLA2G6/SOS2/PDGFC/RELA/GNG7/STK4/GNB1/RASAL2/RHOA/TGFA/AKT3/MET	2.0987738005497
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	39/1161	232/9376	1.35756927737682	PIK3CB/TIAM1/ITGAX/ITGB8/RDX/PIK3R1/RGCC/BRAF/CXCR4/MAP2K1/SRC/MSN/MRAS/ITGAV/GNA13/IQGAP1/IQGAP2/ITGB2/SSH1/ACTR3/GNA12/CYFIP1/CDC42/WASL/RAF1/PPP1R12A/EZR/KRAS/SLC9A1/VAV3/VAV2/ARPC5/SOS2/PDGFC/MYH9/RHOA/ITGAM/AKT3/ITGA4	2.07316584233282
Human Diseases	Cancer: specific types	hsa05218	Melanoma	15/1161	73/9376	1.65941028636154	PIK3CB/GADD45B/PIK3R1/CDKN1A/BRAF/MAP2K1/GADD45A/GADD45G/RAF1/KRAS/DDB2/PDGFC/PTEN/AKT3/MET	2.12619749100394
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	25/1161	139/9376	1.45248142571214	PIK3CB/ATF4/PIK3R1/BCL2/ADCY3/MAP2K1/SRC/HBEGF/CALM1/ITPR1/MMP9/RARA/PRKCD/RAF1/GNAI3/ATF2/GRB2/KRAS/HSP90AB1/ADCY9/HSPA6/SOS2/CTSD/TGFA/AKT3	2.02041530025465
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1161	21/9376	2.307370493417	CSGALNACT2/CHST15/DSE/XYLT1/CHST11/CHST7	2.2546773114497
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	36/1161	217/9376	1.33976351230665	PIK3CB/NFKB1/NOTCH2/ATF4/RPS6KA3/PIK3R1/PRKCB/BCL2/ADCY3/AHR/MAP2K1/ADRB2/SRC/KPNA4/STAT5A/BCL6/RAF1/GNAI3/KPNA2/ARRB2/ATF2/GRB2/KRAS/HSP90AB1/ADCY9/VDR/KLF4/SOS2/RELA/RPS6KB1/KLF5/GSTO2/CYP1B1/PTGES3/AKT3/MYC	1.90362122795526
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	20/1161	108/9376	1.49551791239991	NXF1/IPO5/KPNA4/RBM8A/PNN/EIF4A3/NUP98/SRRM1/IPO7/KPNA2/TNPO1/NUP58/UPF3B/NXT2/NUP153/UBE2I/TNPO3/AHCTF1/SENP2/SAP18	1.9470458907743
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	19/1161	102/9376	1.5043150765905	ATP2B1/PRKCB/ADCY3/ATP2A2/ATP1B3/RAB11A/CA2/RAP1B/ITPR1/KCNMA1/SLC9A1/SLC12A2/ADCY9/RAP1A/ATP1A1/TPCN2/RAB8A/KCNQ1/RHOA	1.92515834389832
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	11/1161	51/9376	1.74183850973637	TJP2/ATP6V1H/ADCY3/PLCG2/ARF1/ATP6V0D1/ATP6V1F/ATP6V1B2/SLC12A2/ADCY9/KCNQ1	1.99695374869384
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	26/1161	150/9376	1.39980476600632	PIK3CB/TCF7L2/GADD45B/PIK3R1/CDKN1A/BRAF/BCL2/MAP2K1/CTNNB1/GADD45A/SMAD2/GADD45G/GSK3B/TCF7/RAF1/GRB2/KRAS/DDB2/SOS2/CSNK1A1/RPS6KB1/TGFB1/AKT3/MYC/CDKN2B/MET	1.85560201539748
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	8/1161	34/9376	1.90018746516695	PRKAG2/CUL1/BHLHE40/NR1D2/NFIL3/CRY1/FBXW11/FBXL3	1.97674410558248
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	15/1161	78/9376	1.5530378321076	PIK3CB/PLCG2/MTMR3/PI4K2A/INPP5A/ITPK1/MTMR14/IPMK/IP6K1/PTEN/PI4K2B/IMPA1/INPP5F/ITPKB/PIK3CG	1.8437640214723
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/1161	78/9376	1.5530378321076	PIK3CB/ARHGAP10/PIK3R1/SRC/CTNNB1/ACTR3/RHOG/CDC42/WASL/HCLS1/ARPC5/RHOA/SEPTIN6/SEPTIN9/MET	1.8437640214723
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	18/1161	98/9376	1.48330960291093	PIK3CB/PIK3R1/PRKCB/PLCG2/MTMR3/CALM1/ITPR1/PI4K2A/INPP5A/ITPK1/MTMR14/IPMK/IP6K1/PTEN/PI4K2B/IMPA1/INPP5F/ITPKB	1.80804502857547
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	18/1161	99/9376	1.468326677629	PIK3CB/GPCPD1/PIK3R1/PRKCB/RHEB/CHKA/MAP2K1/SLC22A1/RALGDS/MAPK8/RAF1/GRB2/KRAS/SOS2/PDGFC/RPS6KB1/WAS/AKT3	1.76100537159962
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	23/1161	134/9376	1.38614421432887	PRKCB/BRAF/ADCY3/MAP2K1/PRKCH/ADM/GNA13/CALM1/ITPR1/ADORA2A/GNA12/PRKCD/RAF1/PPP1R12A/KCNMA1/PRKCE/ADCY9/ADORA2B/PLA2G6/KCNMB4/MYH9/RHOA/EDN1	1.6924541549368
Genetic Information Processing	Transcription	hsa03040	Spliceosome	38/1161	243/9376	1.26288179269326	HNRNPC/SRSF5/DDX5/SRSF3/FUS/PRPF38B/SRSF4/RBM8A/SRSF2/TRA2A/TRA2B/HNRNPA3/RBM22/SRSF6/EIF4A3/HNRNPA1/HNRNPM/RBM17/SF3B1/DHX15/CDC5L/YJU2/WBP11/RBM25/SLU7/TCERG1/CWC25/SMNDC1/SNW1/HSPA6/PRPF40A/SRSF10/PRPF40B/SNIP1/PQBP1/PRPF3/SNRPB/HNRNPU	1.56082739813271
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	55/1161	368/9376	1.20698048908362	MAP2K3/HSPA5/C9orf72/RB1CC1/TANK/ATF4/EIF2AK3/NXF1/XBP1/MAPK13/RAB5A/BCL2/TNF/BID/MAP3K5/MAP1LC3B/ERN1/SRSF3/TBK1/FUS/CASP1/CHMP2B/TNFRSF1B/CYCS/HNRNPA3/PSMD12/NUP98/HNRNPA1/DDIT3/TUBB4B/HNRNPA2B1/ATF6/ATG13/NUP58/TUBA1C/UQCRC2/CASP3/PSMD7/BCL2L1/TUBB6/NXT2/KIF5B/NUP153/DNAH17/SLC1A2/RAB8A/VAPB/SPG11/ATXN2L/PPP3R1/ULK2/PSMD14/PPP3CC/DNAI2/RAB1A	1.52277975238783
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1161	89/9376	1.45182862507137	PRKCB/ADCY3/MAP2K1/SRC/ITPR1/TUBB4B/RAF1/GNAI3/MAP3K2/GRB2/KRAS/ADCY9/TUBA1C/TUBB6/SOS2/PDGFC	1.61001153069606
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	8/1161	37/9376	1.74611821123449	IL1B/PRKCB/TNF/IL18/ICAM1/FAS/IDO2/IL10	1.70944951317703
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/1161	110/9376	1.39491034374755	STK10/PIK3CB/RPS6KA3/PIK3R1/MAPK13/MAD1L1/BRAF/ADCY3/CPEB4/MAP2K1/CPEB2/MAPK8/RAF1/GNAI3/KRAS/HSP90AB1/ADCY9/FZR1/AKT3	1.56619801078176
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1161	38/9376	1.70016773199148	PIK3CB/SGK1/PIK3R1/PRKCB/NEDD4L/ATP1B3/KRAS/ATP1A1	1.62579176581263
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1161	20/9376	2.01894918173988	NANS/CYB5R4/UAP1/GMDS/NPL	1.71482726638789
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	25/1161	154/9376	1.31100596216875	PIK3R5/ATP2B1/ATF4/MAPK13/BCL2/ADCY3/ATP2A2/ATP1B3/ADRB2/CALM1/PPP2CA/GNAI3/PPP2R2D/ATF2/SLC9A1/ADCY9/PPP2R3C/SLC8A1/ATP1A1/KCNQ1/PPP2R5A/PPP2R3A/AKT3/PIK3CG/RPS6KA5	1.46289946286434
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	22/1161	133/9376	1.33584607513616	ATF4/PRKCB/MAPK13/CALM1/ITPR1/PPP2CA/MAPK8/GSK3B/GNAI3/PPP2R2D/ARRB2/ATF2/GNG5/PPP2R3C/GNAL/KIF5B/GNG7/GNB1/PPP2R5A/PPP3CC/PPP2R3A/AKT3	1.46641733334732
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/1161	33/9376	1.71304779056717	STX11/STX3/STX5/STX4/VAMP4/VAMP7/STX18	1.54251855978213
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	11/1161	59/9376	1.50565701689076	MGLL/PIK3CB/PTGS2/PIK3R1/IRS2/ADCY3/ADRB2/GNAI3/ADCY9/ABHD5/AKT3	1.46467733271194
Organismal Systems	Nervous system	hsa04730	Long-term depression	11/1161	60/9376	1.48056273327591	PRKCB/BRAF/MAP2K1/GNA13/ITPR1/PPP2CA/GNA12/RAF1/GNAI3/KRAS/LYN	1.40381196121321
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	23/1161	144/9376	1.28988419944492	PIK3CB/RB1CC1/PIK3R1/PRKCB/XBP1/PPIF/ATP2A2/MAP3K5/ERN1/CYCS/ITPR1/PSMD12/MAPK8/GTF2B/PUM2/ATG13/PSMD7/ATXN2L/NOP56/ULK2/KAT5/PSMD14/AKT3	1.317819278161
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/1161	88/9376	1.37655626027719	ITGAX/CD55/PLAUR/SERPINA1/C5AR1/ITGB2/TFPI/A2M/SERPINB2/PLAU/C3/THBD/ITGAM/F3/F8	1.33416047100262
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	68/1161	480/9376	1.14407120298593	MAP2K3/NFKB1/IL1B/HSPA5/PTGS2/C9orf72/RB1CC1/TANK/UBC/ATF4/EIF2AK3/PRKCB/XBP1/MAPK13/BRAF/RAB5A/UBE2J1/PPIF/BCL2/TNF/BID/ATP2A2/MAP3K5/MAP2K1/PSEN1/CTNNB1/MAP1LC3B/ERN1/TBK1/FUS/PPID/CHMP2B/CALM1/TNFRSF1B/CYCS/ITPR1/PSMD12/IL1A/DDIT3/TUBB4B/MAPK8/CAPN2/GSK3B/RAF1/FAS/KRAS/ATF6/ATG13/TUBA1C/UQCRC2/CASP3/PSMD7/BCL2L1/TUBB6/KIF5B/DNAH17/CSNK1A1/RELA/RAB8A/VAPB/SPG11/ATXN2L/PPP3R1/ULK2/PSMD14/PPP3CC/DNAI2/RAB1A	1.21814329275091
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	19/1161	117/9376	1.31145416933531	BAZ1A/EPC2/GATAD2A/INO80D/BICRAL/ING3/ARID2/BPTF/EPC1/CHRAC1/SRCAP/BCL7B/POLE3/PHF10/INO80/KAT5/INO80C/RBBP4/TRRAP	1.27439189876045
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	47/1161	323/9376	1.17511593240587	PIK3CB/NFKB1/EZH2/CD44/NOTCH2/VIM/PTGS2/RDX/CREBBP/GLS/PIK3R1/MARCKS/CDKN1A/IRS2/PRKCB/SIRT1/BCL2/MAP2K1/PLCG2/RPTOR/SLC7A1/PDCD4/MMP9/BCL2L11/ZEB2/RAF1/PIM1/GRB2/EZR/NOTCH1/KRAS/MCL1/EP300/PRKCE/CASP3/SPRY2/PLAU/SOS2/UBE2I/ST14/RHOA/PTEN/THBS1/CYP1B1/MYC/RPS6KA5/MET	1.20400593033425
NA	NA	hsa04518	Integrin signaling	24/1161	154/9376	1.258565723682	PIK3CB/ITGAX/ITGB8/PIK3R1/LIMS1/SRC/CTNNB1/ITGAV/ICAM1/ITGB2/CDC42/GSK3B/LIMS2/FERMT3/PDGFC/PARVB/C3/TGFB1/ITGAM/THBS1/PARVG/AKT3/ITGA4/MET	1.21623281962771
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1161	76/9376	1.38138628224308	PRKCB/ADCY3/ATP1B3/CA2/SSTR2/CALM1/ITPR1/GNAI3/EZR/SLC9A1/ADCY9/ATP1A1/KCNQ1	1.25495558094938
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	55/1161	388/9376	1.1447649999556	PIK3CB/NFKB1/IL1B/PTGS2/RB1CC1/ATF4/APOE/PIK3R1/EIF2AK3/IRS2/XBP1/BRAF/PPIF/TNF/BID/ATP2A2/MAP3K5/MAP2K1/PSEN1/CTNNB1/ERN1/PPID/SLC11A2/CALM1/CYCS/ITPR1/PSMD12/ADAM17/IL1A/DDIT3/TUBB4B/MAPK8/CAPN2/GSK3B/RAF1/FAS/KRAS/ATF6/ATG13/SLC39A11/TUBA1C/UQCRC2/CASP3/PSMD7/TUBB6/KIF5B/LPL/CSNK1A1/RELA/APH1B/PPP3R1/ULK2/PSMD14/PPP3CC/AKT3	1.09482793389983
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/1161	71/9376	1.36492339047203	PIK3CB/SLC7A5/GLS/PIK3R1/MAP2K1/HK2/RAF1/KRAS/PTEN/AKT3/MYC/MET	1.16030095852018
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/1161	24/9376	1.6824576514499	XYLT1/HS3ST2/HS3ST1/HS6ST1/NDST2	1.25842414749669
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	8/1161	44/9376	1.468326677629	TAF4B/GTF2B/GTF2A1/TAF7/GTF2F2/TAF5L/GTF2H1/TAF2	1.17053885658694
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/1161	44/9376	1.468326677629	RAB5A/ADCY3/RAB11A/DYNC1LI1/STX4/ADCY9/ARHGDIB/DYNC1H1	1.17053885658694
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	18/1161	115/9376	1.26403774856758	PIK3R5/PIK3CB/ATF4/PIK3R1/PRKCB/BCL2/ADCY3/MAP2K1/ITPR1/GNAI3/GNG5/KRAS/ADCY9/GNG7/KCNQ1/GNB1/AKT3/PIK3CG	1.07098641777589
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1161	12/9376	2.01894918173988	NPC1/SLAMF1/FCGR2B	1.3277319607551
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	23/1161	154/9376	1.20612548519525	PIK3R5/PTGS2/PRKAG2/CDKN1A/PRKCB/ADCY3/MAP2K1/SRC/NFATC1/CALM1/ITPR1/RGS2/RAF1/GNAI3/PPP1R12A/KRAS/ADCY9/CAMKK2/PPP3R1/RHOA/PPP3CC/CAMK1D/PIK3CG	0.96956617639108
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1161	89/9376	1.27035004693745	SLC38A2/GLS/PRKCB/ADCY3/SRC/GABARAPL1/GNAI3/GLUL/GNG5/ADCY9/ABAT/GNG7/GNB1/PLCL1	0.963344659326887
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	26/1161	178/9376	1.17961075787049	CREBBP/TCF7L2/PRKCB/SIRT1/CUL1/PSEN1/CTNNB1/NFATC1/FOSL1/MAPK8/TLE4/GSK3B/TCF7/CTBP2/EP300/SIAH1/TBL1XR1/CSNK1A1/FBXW11/PPP3R1/SENP2/TLE3/RHOA/PPP3CC/PPARD/MYC	0.909480952814627
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1161	26/9376	1.5530378321076	SLC19A2/BTD/CUBN/LMBRD1/TCN2	1.06153342655844
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	8/1161	47/9376	1.37460369820588	PIK3CB/PIK3R1/IRS2/TNF/HK2/PRKCD/MAPK8/PRKCE	0.967835186384894
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	28/1161	195/9376	1.15960158130701	PIK3CB/NFKB1/AQP9/FCGR2A/PIK3R1/PRKCB/MAPK13/CLEC7A/PPIF/MAP2K1/SRC/PLCG2/NCF2/C5AR1/CASP1/HDAC9/SYK/ITGB2/TLR2/FPR1/RAF1/FPR3/FCGR1A/RELA/C3/ITGAM/FCGR3A/AKT3	0.846656927349552
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	15/1161	98/9376	1.23609133575911	ATP2B1/ATF4/PRKCB/ADCY3/ATP1B3/CALM1/ITPR1/ATF2/PRKCE/ADCY9/NR4A2/ATP1A1/NR4A1/CAMK1D/ATF1	0.883209775551817
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	21/1161	143/9376	1.18595616270035	HLA-DRA/HLA-DRB5/HLA-DQB1/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DPA1/FCGR2A/HLA-DMA/HLA-DQA2/TNF/HLA-DMB/CD86/CD40/FCGR1A/IL10/HLA-DOA/CD80/C3/SNRPB/FCGR3A	0.842374362775872
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	23/1161	158/9376	1.17559066278525	CREBBP/GADD45B/CDKN1A/MAD1L1/CUL1/CDC14A/STAG2/NIPBL/GADD45A/SMAD2/GADD45G/STAG1/PPP2CA/GSK3B/EP300/DBF4/PTTG1/FZR1/TGFB1/PPP2R5A/CHEK1/MYC/CDKN2B	0.836776690572543
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	8/1161	48/9376	1.34596612115992	PIK3CB/PIK3R1/PRKCB/ATP1B3/HK2/MGAM/ATP1A1/AKT3	0.903353822544752
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	32/1161	227/9376	1.13843830512205	NFKBIA/SOD2/PIK3CB/NFKB1/NFE2L2/ABL2/PIK3R1/MAPK13/PTPRJ/BRAF/PPIF/AHR/MAP3K5/MAP2K1/SRC/NCF2/FOXO3/PTPN1/PRKCD/MAPK8/RAF1/GRB2/KRAS/UQCRC2/SOS2/RELA/PTEN/GSTO2/CYP1B1/AKT3/MAP2K4/MET	0.793743812131018
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1161	63/9376	1.28187249634278	TCF7L2/GADD45B/CDKN1A/CTNNB1/GADD45A/GADD45G/GSK3B/TCF7/PTCH2/DDB2	0.843871149127629
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1161	93/9376	1.21571133524122	LYZ/ATP2B1/PRKCB/ADCY3/ATP1B3/ADRB2/CALM1/ITPR1/KCNMA1/SLC9A1/SLC12A2/ADCY9/ATP1A1/KCNN4	0.785901703838939
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	5/1161	28/9376	1.44210655838563	SLC12A7/CA2/ATP6V0D1/ATP6V1F/ATP6V1B2	0.880733641464199
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	15/1161	101/9376	1.19937575152864	CREBBP/TCF7L2/PRKCB/ADCY3/MAP2K1/CTNNB1/CALM1/GSK3B/TCF7/RAF1/GNAI3/KRAS/EP300/ADCY9/EDN1	0.757310589059342
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	10/1161	65/9376	1.24243026568608	PIK3CB/PIK3R1/PRKCB/MAP2K1/ITPR1/RAF1/ARRB2/KRAS/KCNN4/AKT3	0.737298442737362
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1161	29/9376	1.3923787460275	MOB1A/STK3/SAV1/RASSF2/LATS2	0.79554786892868
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1161	23/9376	1.40448638729731	GLS/ATP1B3/CA2/ATP1A1	0.730113410228625
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/1161	75/9376	1.18445018662073	HSPA5/ATF4/PRKCB/ADCY3/ATP1B3/ITPR1/ATF2/ADCY9/ATP1A1/CANX/PAX8	0.602896652705454
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	20/1161	144/9376	1.12163843429993	PIK3CB/JARID2/PIK3R1/MAPK13/ID2/MAP2K1/CTNNB1/SKIL/SMAD2/GSK3B/TCF7/RAF1/GRB2/KRAS/ACVR2A/JAK1/KLF4/PCGF5/AKT3/MYC	0.552970717247486
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1161	53/9376	1.21898818520144	ATP2B1/PRKCB/ATP1B3/RAB11A/ADCY9/SLC8A1/ATP1A1/VDR	0.601005908240312
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1161	31/9376	1.30254785918702	ACOX3/ABAT/UPB1/DPYS/ALDH9A1	0.634283249522508
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/1161	76/9376	1.16886531574414	ACSL5/UBC/ACSL1/OLR1/FABP5/ACSL3/ACOX3/LPL/NR1H3/PPARD/PPARG	0.555653101038443
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1161	107/9376	1.13212103648965	CREBBP/PRKAG2/ATF4/SIRT1/PPP4R3A/CALM1/ITPR1/PPP4R3B/ATF2/EP300/FBP1/PPP3R1/PPP3CC/FOXO1/AKT3	0.516708236050108
Organismal Systems	Endocrine system	hsa04924	Renin secretion	10/1161	69/9376	1.17040532274776	PTGER4/ADRB2/CALM1/ITPR1/GNAI3/PTGER2/KCNMA1/PPP3R1/PPP3CC/EDN1	0.534073228685524
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1161	17/9376	1.42514059887521	CA2/GLUL/CA13	0.659538695927762
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1161	17/9376	1.42514059887521	NRP2/MYH9/TFRC	0.659538695927762
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/1161	10/9376	1.6151593453919	SQOR/ETHE1	0.73165865368838
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	21/1161	155/9376	1.0941402017171	TCF7L2/ATF4/CDKN1A/BRAF/ADCY3/AHR/MAP2K1/CTNNB1/RAP1B/ITPR1/GSK3B/TCF7/GNAI3/ATF2/ADCY9/RAP1A/FH/NR4A1/PDE8A/ARMC5/CDKN2B	0.444273006479023
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1161	18/9376	1.34596612115992	ACSL5/ACSL1/ACSL3	0.552301558538297
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1161	18/9376	1.34596612115992	ZNF143/LMBRD1/TCN2	0.552301558538297
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	6/1161	42/9376	1.1536852467085	KYNU/KMO/IL4I1/IDO2/ALDH9A1/CYP1B1	0.375250163143841
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	3/1161	19/9376	1.27512579899361	ARSB/GNS/GUSB	0.451271354686108
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	18/1161	138/9376	1.05336479047298	RPS6KA3/MAPK13/MAD1L1/CUL1/ADCY3/CPEB4/MAP2K1/CPEB2/CALM1/ITPR1/PPP2CA/ADCY9/PTTG1/FBXW11/PPP3R1/PPP2R5A/PPP3CC/REC8	0.237412366487649
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	8/1161	59/9376	1.09502328501146	UPP1/NT5C2/CMPK2/ASMTL/UPB1/DPYS/TYMP/UCK2	0.275242796969195
Human Diseases	Substance dependence	hsa05032	Morphine addiction	12/1161	91/9376	1.06494022773093	PRKCB/ADCY3/PDE7A/PDE4B/GNAI3/ARRB2/GNG5/ADCY9/PDE4A/GNG7/GNB1/PDE8A	0.234013824074901
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	3/1161	20/9376	1.21136950904393	SOAT1/LIPA/LSS	0.355721564811149
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	5/1161	36/9376	1.12163843429993	B4GALT5/ST3GAL1/GALNT4/GALNT6/GCNT4	0.274882187226324
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	15/1161	116/9376	1.04428405952063	SLC38A2/SLC1A3/GLS/PRKCB/ADCY3/ITPR1/GNAI3/GLUL/GNG5/ADCY9/SLC1A2/GNG7/PPP3R1/GNB1/PPP3CC	0.180413441599554
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	20/1161	157/9376	1.02876391426236	TP53BP2/SMAD7/BIRC2/TCF7L2/ID2/CTNNB1/SMAD2/ITGB2/PPP2CA/MOB1A/GSK3B/TCF7/PPP2R2D/BIRC3/STK3/SAV1/FBXW11/LATS2/TGFB1/MYC	0.136632453960438
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/1161	85/9376	1.04510310584182	AMPD3/ADK/UPP1/PNP/ADA2/ADA/NT5C2/CMPK2/ASMTL/TYMP/UCK2	0.157030005475634
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1161	37/9376	1.09132388202156	GLS/GLUL/IL4I1/ABAT/RIMKLB	0.209234358996396
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/1161	21/9376	1.1536852467085	BCAT1/UPB1/DPYS	0.26504394936477
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1161	86/9376	1.03295074414598	SNTB1/ITGB8/TCF7L2/ATP2A2/CTNNB1/ITGAV/TCF7/SLC8A1/EMD/DSC2/ITGA4	0.115399668106793
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1161	54/9376	1.04686253867994	SMS/GCLC/AMD1/SDS/BCAT1/IL4I1/SDSL	0.129827324352012
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	23/1161	184/9376	1.00947459086994	PIK3CB/PIK3R1/SEMA6B/CXCR4/SRC/PLCG2/PLXNC1/SEMA3C/SRGAP1/SEMA4D/SSH1/CDC42/SRGAP3/GSK3B/RAF1/GNAI3/KRAS/NRP1/SEMA4A/PPP3R1/RHOA/PPP3CC/MET	0.0487935406395895
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	5/1161	38/9376	1.06260483249467	ADA/CD40/CD4/IL7R/CIITA	0.145368626001116
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1161	30/9376	1.07677289692794	NFKB1/IL1B/TNF/RELA	0.1583265074377
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/1161	63/9376	1.02549799707422	EZH2/DOT1L/KMT2E/PRDM2/KMT2C/SETDB2/ASH1L/ALDH9A1	0.0763360184858625
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1161	14/9376	1.1536852467085	ST3GAL1/B3GNT2	0.216326559010548
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/1161	31/9376	1.04203828734962	HSPA5/SPCS3/SRP54/SRP68	0.0881321109860919
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/1161	56/9376	1.00947459086994	MGAT1/STT3B/MAGT1/DPM1/MAN2A1/ALG2/MGAT5	0.0267328023193988
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/1161	57/9376	0.991764510328362	ACSL5/ACSL1/ELOVL7/ACSL3/ELOVL5/PPT1/ACOX3	-0.0234444561673753
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1161	41/9376	0.984853259385307	NBN/RBBP8/BLM/BABAM2/BRCA2	-0.0365386013965818
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	6/1161	50/9376	0.969095607235142	SMS/AMD1/CKB/SAT1/GATM/ALDH9A1	-0.082367422401671
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1161	16/9376	1.00947459086994	ST3GAL1/GLA	0.0142587185472182
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	32/1161	268/9376	0.964274236054868	NFE2L2/HSPA5/UBC/ATF4/EIF2AK3/XBP1/UBE2J1/PPIF/MAP3K5/ERN1/SLC11A2/CALM1/CYCS/ITPR1/ADORA2A/PSMD12/DDIT3/TUBB4B/MAPK8/TXN/GNAI3/ATF6/SLC39A11/TUBA1C/UQCRC2/CASP3/PSMD7/BCL2L1/GNAL/TUBB6/KIF5B/PSMD14	-0.223067024663837
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/1161	43/9376	0.939046131041804	ACSL5/ACSL1/ACSL3/ACOX3/ALDH9A1	-0.150599259383902
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	10/1161	86/9376	0.939046131041804	ATF4/PRKCB/ADCY3/ATP1B3/ATF2/KCNMA1/ADCY9/ATP1A1/KCNMB4/KCNN4	-0.213471848054084
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1161	69/9376	0.936324258198205	ATF4/PRKCB/SIRT1/CALM1/ATF2/PPP3R1/ARC/PPP3CC	-0.199568349536653
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	30/1161	254/9376	0.953834259089707	P2RX4/SPHK1/ATP2B1/PRKCB/PPIF/ADCY3/ATP2A2/CXCR4/ADRB2/PLCG2/NFATC1/CALM1/ITPR1/ADORA2A/P2RX7/PTK2B/GNA15/ADCY9/ADORA2B/GNAL/SLC8A1/PDGFC/TPCN2/PPP3R1/MCOLN2/PPP3CC/TGFA/CAMK1D/ITPKB/MET	-0.280407482579215
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1161	17/9376	0.950093732583473	TXNRD1/SEPHS2	-0.0774217155868007
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	4/1161	35/9376	0.922948197366802	PFKFB3/HK2/GMDS/FBP1	-0.171679367202369
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1161	44/9376	0.917704173518127	MGAT1/STT3B/MAGT1/MAN2A1/ALG2	-0.20569074373397
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1161	27/9376	0.897310747439946	ELOVL7/ELOVL5/ACOX3	-0.200873320734228
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	11/1161	97/9376	0.915811999964481	PRKCB/ADCY3/CALM1/ITPR1/GNAI3/GNG5/ADCY9/GNG7/ADCY10/GNB1/RPS6KA5	-0.313316622681594
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/1161	18/9376	0.897310747439946	MANBA/NEU3	-0.163933491649127
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	32/1161	275/9376	0.939729073682562	PIK3CB/IL1B/HSPA5/ATF4/PIK3R1/EIF2AK3/MAPK13/PPIF/TNF/NCF2/CYCS/ITPR1/PSMD12/IL1A/DDIT3/TUBB4B/PRKCD/MAPK8/GSK3B/ATF2/NOTCH1/TUBA1C/UQCRC2/CASP3/PSMD7/HSPA6/TUBB6/KIF5B/PPP3R1/PSMD14/PPP3CC/CCL5	-0.381353397769335
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/1161	115/9376	0.91291615174325	PTGS2/PRKCB/BRAF/MAP2K1/ITPR1/RAF1/GNAI3/GNG5/KRAS/CASP3/GNG7/GNB1/ALOX5	-0.353228351614905
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/1161	37/9376	0.873059105617245	NANS/HK2/UAP1/GMDS	-0.290837359063815
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1161	28/9376	0.865263935031377	ELOVL7/ELOVL5/PPT1	-0.26841172763799
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1161	28/9376	0.865263935031377	ST3GAL6/B3GNT2/B3GNT5	-0.26841172763799
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	11/1161	99/9376	0.897310747439946	SNTB1/ITGB8/PRKAG2/TNF/ATP2A2/ITGAV/SLC8A1/EMD/TGFB1/EDN1/ITGA4	-0.38613287263353
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1161	38/9376	0.850083865995739	PNP/SIRT1/NT5C2/SIRT7	-0.348105753936054
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/1161	65/9376	0.869701185980256	MGLL/GLA/LPL/GPAT4/AGPAT4/MOGAT1/ALDH9A1	-0.396275243915631
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	7/1161	65/9376	0.869701185980256	ATF4/ADCY3/ITPR1/ATF2/ADCY9/NR4A1/PDE8A	-0.396275243915631
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1161	29/9376	0.835427247616502	SLC24A1/CALM1/GNB1	-0.333671239250156
NA	NA	hsa03272	Virion - Hepatitis viruses	5/1161	48/9376	0.84122882572495	CHMP4B/CHMP1B/VPS4B/IST1/PDCD6IP	-0.414568185781948
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/1161	49/9376	0.824060890506073	NFKB1/ATF4/GNAI3/ATF2/RELA	-0.464181048621931
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/1161	59/9376	0.821267463758595	SMS/GCLC/ANPEP/GSTK1/GSTO2/GGCT	-0.517713560192634
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/1161	41/9376	0.787882607508246	SDS/SDSL/GATM/BPGM	-0.511692452567662
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/1161	105/9376	0.846035847586235	SNTB1/ITGB8/ADCY3/TNF/ATP2A2/ITGAV/ADCY9/SLC8A1/EMD/TGFB1/ITGA4	-0.596415523420638
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	5/1161	51/9376	0.791744777152894	LPCAT1/PLA2G6/PAFAH1B1/PLA2G7/PLD4	-0.560601859422738
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/1161	32/9376	0.757105943152455	GLA/HK2/MGAM	-0.517396429108369
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/1161	61/9376	0.794340661668149	ATP2B1/ATP1B3/SLC11A2/SLC8A1/ATP1A1/VDR	-0.605786912142979
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/1161	52/9376	0.7765189160538	PTGS2/ADCY3/ADCY9/ALOX5/CYP1B1	-0.607490194977558
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1161	23/9376	0.702243193648654	GLS/GLUL	-0.537462431694083
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1161	23/9376	0.702243193648654	PDSS1/NUS1	-0.537462431694083
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1161	23/9376	0.702243193648654	ANPEP/NLN	-0.537462431694083
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/1161	44/9376	0.734163338814502	POLE3/TDG/POLG/POLG2	-0.664433943840939
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	5/1161	54/9376	0.747758956199955	REV3L/WDR48/BLM/HES1/BRCA2	-0.698805073962806
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/1161	128/9376	0.820198105081826	AMPD3/ADK/PNP/ADA2/ADA/ADCY3/NT5C2/PDE7A/PDE4B/ADCY9/PDE4A/ADCY10/PDE8A	-0.769969111071488
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/1161	83/9376	0.778390045972002	SOD2/ACSL5/ACSL1/ACSL3/GSTK1/ACOX3/FAR2/PEX13	-0.762339293706105
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	4/1161	45/9376	0.717848597951957	ABCA1/ABCG1/ABCA5/ABCA13	-0.713218071913137
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1161	46/9376	0.702243193648654	PSMD12/PSMD7/PSME4/PSMD14	-0.761022953438906
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	10/1161	104/9376	0.7765189160538	GPCPD1/LPCAT1/SGMS2/CHKA/PLA2G6/GPAT4/AGPAT4/PTDSS1/PISD/PLD4	-0.86152660095465
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1161	26/9376	0.62121513284304	ACOX3/PLA2G6	-0.727062010259326
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/1161	48/9376	0.67298306057996	BCAT1/IL4I1/ABAT/ALDH9A1	-0.853875521890848
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/1161	15/9376	0.538386448463968	ST3GAL1	-0.672606439571581
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	4/1161	49/9376	0.659248712404858	OGT/GALNT4/GALNT6/LFNG	-0.89900585748188
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/1161	79/9376	0.715576925173628	ATP6V1H/SLC1A3/STX3/ATP6V0D1/ATP6V1F/ATP6V1B2/SLC1A2	-0.954343943059325
NA	NA	hsa04519	Cadherin signaling	43/1161	404/9376	0.85955262192886	NFKBIA/MAP2K3/ERBIN/NFKB1/VIM/CREBBP/TCF7L2/MAPK13/SHOC2/MAP2K1/PSEN1/CTNNB1/LHFPL2/MRAS/FMN1/ACTR3/CYFIP1/CDC42/MAPK8/MOB1A/GSK3B/TCF7/RAF1/PTK2B/KRAS/EP300/STK3/SAV1/VAV3/VAV2/ARPC5/CSNK1A1/RELA/APH1B/VASP/MYO1G/LATS2/TAOK3/DSC2/RHOA/CDH23/MYO1E/MET	-1.08481991746249
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/1161	16/9376	0.50473729543497	IL4I1	-0.745342105877316
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1161	90/9376	0.717848597951957	AQP9/ADCY3/ATP1B3/CA2/SLC22A1/SLC9A1/ADCY9/ATP1A1	-1.01108366012067
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	7/1161	82/9376	0.689397281569715	UPP1/UPB1/DPYS/GUSB/TYMP/GSTO2/UCK2	-1.06196158911774
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/1161	63/9376	0.64093624817139	PTGS2/TBXAS1/PLA2G6/ALOX5/PTGES3	-1.07496667747679
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/1161	103/9376	0.705652141190637	SLC38A2/ATP1B3/SLC36A4/SLC7A7/SLC36A3/SLC8A1/ATP1A1/KCNN4/KCNQ1	-1.12919079086308
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	23/1161	235/9376	0.790397126468378	MAP2K3/MGLL/ACSL5/PRKAG2/ACSL1/RPS6KA3/MAPK13/RHEB/ADCY3/MAP3K5/ACSL3/RPTOR/ZNF516/ATF2/GRB2/KRAS/ADCY9/UQCRC2/SOS2/ADCY10/RPS6KB1/KDM1A/PPARG	-1.22329802091654
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1161	31/9376	0.521019143674808	GUSB/ALDH9A1	-1.00417016608674
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/1161	32/9376	0.50473729543497	ACOX3/ABAT	-1.05497498843019
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	7/1161	87/9376	0.649776748146168	ATP2A2/ATP1B3/SLC9A1/UQCRC2/SLC8A1/ATP1A1/SLC9A7	-1.23372420439991
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	19/1161	205/9376	0.748488477132833	PIK3CB/NFKB1/PIK3R1/PRKCB/MAPK13/PPIF/ATP2A2/NCF2/SMAD2/MMP9/PRKCD/MAPK8/GSK3B/UQCRC2/RELA/CTSD/TGFB1/PTEN/AKT3	-1.36875095376858
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	30/1161	308/9376	0.786603577301252	SOD2/RB1CC1/SLC1A3/CREBBP/PPIF/MAP3K5/ERN1/RCOR1/TAF4B/CYCS/ITPR1/PSMD12/TUBB4B/MAPK8/EP300/ATG13/TUBA1C/UQCRC2/CASP3/PSMD7/TUBB6/KIF5B/DNAH17/SLC1A2/SIN3A/ULK2/PSMD14/NRF1/DNAI2/PPARG	-1.43154400145553
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/1161	47/9376	0.515476386827203	FH/ME2/ALDH9A1	-1.25182694060125
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1161	22/9376	0.367081669407251	ALDH9A1	-1.11727040672965
NA	NA	hsa04081	Hormone signaling	20/1161	219/9376	0.737515682827353	PIK3CB/PIK3R1/IRS2/ADCY3/ADRB2/SRC/ITGAV/STAT5A/SSTR2/GNA13/GNA12/GNAI3/GNG5/GNA15/ADCY9/ADIPOR2/GNG7/GNB1/RHOA/HAMP	-1.4775656116903
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1161	36/9376	0.448655373719973	GUSB/CRYL1	-1.24594514603529
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/1161	36/9376	0.448655373719973	HK2/MGAM	-1.24594514603529
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/1161	191/9376	0.718788190357653	ATF4/BRAF/MAP2K1/HDAC9/CALM1/ADORA2A/RAF1/GNAI3/ATF2/GRB2/GNG5/KRAS/ADORA2B/SOS2/CAMKK2/GNG7/GNB1	-1.47607567266812
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1161	23/9376	0.351121596824327	MSH6	-1.17125035265544
Cellular Processes	Cell motility	hsa04814	Motor proteins	17/1161	194/9376	0.707672909063463	MYO9B/KIF13B/MYO16/DYNC1LI1/TUBB4B/KIF1B/TUBA1C/TUBB6/KIF5B/DNAH17/MYH9/MYO1G/KIF21B/DNAI2/DYNC1H1/MYO1E/KIF20B	-1.54667565497394
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/1161	38/9376	0.425041932997869	HK2/UAP1	-1.33505451381039
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	4/1161	63/9376	0.512748998537112	POLE3/DDB2/ERCC6/GTF2H1	-1.45873424279767
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	2/1161	39/9376	0.41414342189536	MTHFD2/MTHFD2L	-1.37821794054878
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	12/1161	149/9376	0.650399736399424	MGLL/PTGS2/PRKCB/MAPK13/ADCY3/ITPR1/MAPK8/GNAI3/GNG5/ADCY9/GNG7/GNB1	-1.61708403512878
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1161	26/9376	0.31060756642152	HES1	-1.32326048919858
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1161	27/9376	0.299103582479982	ABAT	-1.3710430971891
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/1161	67/9376	0.482137118027434	HK2/FBP1/ALDH9A1/BPGM	-1.59918473024835
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/1161	28/9376	0.288421311677126	GCH1	-1.41755709674018
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/1161	70/9376	0.461474098683401	PTGS2/GSTK1/GSTO2/CYP1B1	-1.70009056185382
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/1161	30/9376	0.269193224231984	FH	-1.50712151096455
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	1/1161	30/9376	0.269193224231984	PIGA	-1.50712151096455
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/1161	30/9376	0.269193224231984	PLA2G6	-1.50712151096455
NA	NA	hsa04082	Neuroactive ligand signaling	16/1161	199/9376	0.649310289604785	P2RX4/OGFRL1/SLC1A3/PRKCB/ADCY3/ADRB2/ADORA2A/GNAI3/GNG5/ADCY9/ADORA2B/GNAL/SLC1A2/GNG7/GNB1/P2RY1	-1.87973730280615
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/1161	46/9376	0.351121596824327	GUSB/HCCS	-1.65843852524663
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/1161	31/9376	0.260509571837404	FBP1	-1.55032130462316
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/1161	31/9376	0.260509571837404	GLUL	-1.55032130462316
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	19/1161	233/9376	0.658541364000991	AMPD3/VIM/SNTB1/ITGB8/ATP1B3/ITGAV/SDC2/INF2/FMNL3/ATP1A1/TMOD3/SUN2/MYH9/EMD/DSC2/SYNPO2/THBS1/ITGA4/FMNL2	-1.98412790885167
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/1161	33/9376	0.244721112938167	BCAT1	-1.63387604101232
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/1161	75/9376	0.430709158771174	SDS/BCAT1/GLUL/SDSL	-1.860792601411
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	11/1161	154/9376	0.576842623354251	KYNU/KMO/GCH1/GCLC/MTHFD2/CMPK2/PDXK/BCAT1/MTHFD2L/IDO2/GUSB	-1.99043354244848
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/1161	34/9376	0.237523433145868	CRCP	-1.67434130944508
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	5/1161	89/9376	0.453696445334804	CD44/ITGB8/ITGAV/THBS1/ITGA4	-1.94665626183438
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/1161	36/9376	0.224327686859987	POLE3	-1.75288759045583
Genetic Information Processing	Translation	hsa03010	Ribosome	17/1161	222/9376	0.618416866478882	RPS20/RPL36AL/RPS27/RPL21/RPL22L1/RPL36A/RPL13A/RPL23/MRPS24/RPS17/RPS9/MRPL44/RPL9/RPL30/RPS29/RPL38/RPL31	-2.16300820781762
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/1161	116/9376	0.487332561109626	HK2/SDS/ACOX3/FBP1/FH/SDSL/ME2	-2.0886092658953
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1161	37/9376	0.218264776404311	IL4I1	-1.79105251324445
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/1161	68/9376	0.356285149718802	ALDH1A2/DHRS9/ALDH1A1	-2.00270859416579
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/1161	43/9376	0.187809226208361	ABCA1	-2.00668687815941
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	3/1161	79/9376	0.306675825074412	GSTK1/GSTO2/CYP1B1	-2.32635740725593
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/1161	66/9376	0.244721112938167	DHRS9/CYP1B1	-2.3147411703137
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/1161	73/9376	0.221254704848206	GSTK1/GSTO2	-2.51098038190905
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/1161	138/9376	0.351121596824327	ATP6V1H/ATP6V0D1/CYCS/ATP6V1F/ATP6V1B2/UQCRC2	-2.88676777132034
NA	NA	hsa04382	Cornified envelope formation	11/1161	217/9376	0.40937218431592	S100A4/PPP2CA/PPP2R2D/S100A8/S100A9/PPP2R3C/UGCG/ABHD5/ST14/PPP2R5A/PPP2R3A	-3.30915948014546
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	7/1161	183/9376	0.308910257315391	NXF1/GTPBP4/TCOF1/NXT2/NOP56/GNL3/WDR43	-3.54919062847088
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/1161	86/9376	0.0939046131041804	P2RY1	-3.17331549350198
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	18/1161	370/9376	0.39287659752776	NR3C1/P2RX4/OGFRL1/PTGER4/ADRB2/C5AR1/ADM/SSTR2/ADORA2A/FPR1/PTGER2/P2RX7/ADORA2B/FPR3/C3/P2RY8/P2RY1/EDN1	-4.47929668345171
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/1161	449/9376	0.143889473977007	ADCY3/CALM1/RGS2/ARRB2/GNAL/SLC8A1/GNG7/GNB1	-6.98872906149508