category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
NA	NA	hsa04518	Integrin signaling	15/152	154/9376	6.0082023239918	FLT1/FN1/VEGFA/LAMB1/THBS1/PDGFD/PIK3R1/FBN1/PDGFRA/FERMT2/IGF1R/COL4A1/COL4A2/ITGB1/ACTN1	8.04409983406739
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	14/152	203/9376	4.2540834845735	FLT1/FN1/VEGFA/LAMB1/THBS1/PDGFD/PIK3R1/PDGFRA/IGF1R/COL4A1/PTEN/COL4A2/ITGB1/ACTN1	6.0168446421515
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	10/152	101/9376	6.10734757686295	SERPINE1/FOXO1/FN1/VEGFA/PIK3R1/JAK2/CXCL8/COL4A1/F3/COL4A2	6.62440577700324
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	15/152	233/9376	3.97108651456969	FN1/SYNE2/THBS1/NID1/FBN1/TPM1/COL11A1/FHL1/COL4A1/PDLIM3/COL4A2/ITGB1/PDLIM1/ACTG2/DIAPH2	5.89517475583269
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	9/152	80/9376	6.93947368421053	VEGFA/PDGFD/PIK3R1/JAK2/NRG2/PDGFRA/FOXO3/IGF1R/PTEN	6.8484562146898
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	19/152	362/9376	3.23756906077348	FLT1/FN1/PRLR/VEGFA/LAMB1/THBS1/PDGFD/PIK3R1/LPAR1/JAK2/INSR/PDGFRA/FOXO3/IGF1R/IGF2/COL4A1/PTEN/COL4A2/ITGB1	5.57339394928006
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	11/152	133/9376	5.10170162247725	FOXO1/FBXO32/PIK3R1/INSR/GABARAPL1/IRS2/FOXO3/TNFSF10/IGF1R/PTEN/HOMER1	6.1154890586641
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	7/152	62/9376	6.96434634974533	FOXO1/PIK3R1/INSR/IRS2/FOXO3/IGF1R/ADCY3	6.04837024180757
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	8/152	90/9376	5.48304093567251	FOXO1/PIK3R1/INSR/SESN1/IRS2/FOXO3/IGF1R/ADCY3	5.48564128038681
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	8/152	93/9376	5.30616864742501	FN1/LAMB1/PIK3R1/PTGS2/COL4A1/PTEN/COL4A2/ITGB1	5.35717851804958
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	12/152	212/9376	3.49155908639523	FLT1/VEGFA/THBS1/PDGFD/PIK3R1/LPAR1/INSR/PDGFRA/IGF1R/GNAI1/ADCY3/ITGB1	4.71025442240492
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	10/152	157/9376	3.92893060677171	SERPINE1/IGFBP3/FOXO1/HLA-G/PIK3R1/HIPK3/FOXO3/CXCL8/PTEN/HIPK2	4.75077854072407
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	8/152	103/9376	4.79100664282064	SLC38A2/COL11A1/SLC7A8/MME/COL4A1/COL4A2/COL12A1/COL17A1	4.96604685587206
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	8/152	103/9376	4.79100664282064	FN1/LAMB1/PIK3R1/CXCL8/IL1R1/COL4A1/COL4A2/ACTN1	4.96604685587206
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	6/152	59/9376	6.27297056199822	PIK3R1/INSR/IRS2/PTGS2/GNAI1/ADCY3	5.21544163738973
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	12/152	238/9376	3.11012826183105	FLT1/VEGFA/PLA2G4A/PDGFD/PIK3R1/PLA2G5/INSR/PLA2G2A/RASAL2/PDGFRA/IGF1R/IGF2	4.23272000622204
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/152	43/9376	7.17258261933905	PLA2G5/APOB/PLA2G2A/APOA1/PLPP1	5.20760807234619
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	9/152	149/9376	3.72589191098552	PLA2G4A/PDGFD/PIK3R1/LPAR1/INSR/PDGFRA/CXCL8/ADCY3/PLPP1	4.30545733375294
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/152	52/9376	5.93117408906883	PLA2G4A/INSR/PTGS2/IGF1R/ADCY3	4.57718703858411
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	5/152	52/9376	5.93117408906883	APOA2/APOC3/APOB/APOA1/APOC2	4.57718703858411
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	8/152	134/9376	3.68263943440691	PLA2G4A/CALD1/PLA2G5/KCNMA1/PLA2G2A/ADM/ADCY3/ACTG2	4.01494413237477
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	7/152	106/9376	4.07348560079444	FOXO1/PDGFD/PIK3R1/PDGFRA/IGF1R/TCF7L2/PTEN	4.08499974155124
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	7/152	110/9376	3.92535885167464	SERPINE1/FLT1/VEGFA/PIK3R1/INSR/TF/IGF1R	3.9616593380805
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	13/152	333/9376	2.40809230282915	FOXO1/FN1/HLA-G/VEGFA/LAMB1/THBS1/PIK3R1/PTGS2/TCF7L2/COL4A1/PTEN/COL4A2/ITGB1	3.35849542349928
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/152	88/9376	4.20574162679426	SERPINE1/SERPINE2/C7/F3/SERPING1/SERPINC1	3.87843515159414
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	6/152	89/9376	4.15848610289769	FN1/LAMB1/THBS1/COL4A1/COL4A2/ITGB1	3.84312080162518
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/152	63/9376	4.89557226399332	PLA2G4A/PLA2G5/PLA2G2A/GGT5/PTGS2	3.98239673611427
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	6/152	99/9376	3.7384370015949	PLA2G4A/PDGFD/PIK3R1/SLC22A3/PDGFRA/PLPP1	3.5161254234078
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	9/152	204/9376	2.72136222910217	FN1/TIMP3/VEGFA/THBS1/PIK3R1/CTSL/IGF1R/IGF2/ITGB1	3.19082594697092
Human Diseases	Cancer: specific types	hsa05218	Melanoma	5/152	73/9376	4.22494592645999	PDGFD/PIK3R1/PDGFRA/IGF1R/PTEN	3.55075037601318
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	5/152	75/9376	4.11228070175439	SERPINE1/IGFBP3/THBS1/SESN1/PTEN	3.47370036561267
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	5/152	76/9376	4.05817174515235	APOA2/APOC3/APOA1/SORBS1/PLIN2	3.43617266272869
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/152	26/9376	7.11740890688259	PLA2G4A/PLA2G5/PLA2G2A	4.00955490292926
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/152	26/9376	7.11740890688259	SLC19A3/APOB/APOA1	4.00955490292926
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/152	50/9376	4.93473684210526	SAT1/AOC1/CKB/MAOA	3.58097074801395
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	6/152	110/9376	3.36459330143541	THBS1/FBN1/INHBA/BMP2/TF/ID4	3.20224410349916
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/152	51/9376	4.83797729618163	PLA2G4A/PLA2G5/PLA2G2A/PLPP1	3.52785603536129
NA	NA	hsa04081	Hormone signaling	9/152	219/9376	2.53496755587599	PRLR/PIK3R1/JAK2/INSR/IRS2/IGF1R/IGF2/GNAI1/ADCY3	2.95047837375793
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	6/152	116/9376	3.19056261343013	GLUL/SLC38A2/PLA2G4A/GNAI1/ADCY3/HOMER1	3.04738241805377
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	9/152	227/9376	2.44562949223278	HLA-G/VEGFA/PIK3R1/PDGFRA/PTGS2/CXCL8/IL1R1/GNAI1/ADCY3	2.83028975611928
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/152	30/9376	6.16842105263158	PLA2G4A/PLA2G5/PLA2G2A	3.63959794276207
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	9/152	232/9376	2.3929219600726	FN1/PDGFD/PIK3R1/C7/LPAR1/PDGFRA/ITGB1/ACTN1/DIAPH2	2.75772181154021
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	6/152	122/9376	3.03364969801553	FOXO1/PIK3R1/INSR/IRS2/FOXO3/IGF1R	2.90227859851051
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	6/152	122/9376	3.03364969801553	IGFBP3/PIK3R1/JAK2/IRS2/GNAI1/ADCY3	2.90227859851051
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	8/152	196/9376	2.51772287862513	HLA-G/VEGFA/PIK3R1/JAK2/IL6ST/PTGS2/CXCL8/TCF7L2	2.75642995556726
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	5/152	89/9376	3.46540508574808	PDGFD/LPAR1/PDGFRA/GNAI1/ADCY3	2.99980726867167
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/152	89/9376	3.46540508574808	GLUL/SLC38A2/GABARAPL1/GNAI1/ADCY3	2.99980726867167
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/152	59/9376	4.18198037466548	GPX3/GGT5/ANPEP/GSTM3	3.14726447649622
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	4/152	59/9376	4.18198037466548	PIK3R1/FOXO3/TCF7L2/PTEN	3.14726447649622
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	4/152	60/9376	4.11228070175439	VEGFA/PLA2G4A/PIK3R1/PTGS2	3.10446973343032
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	5/152	93/9376	3.31635540464063	INSR/SORBS1/IGF1R/TCF7L2/ACTN1	2.88171003737376
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	6/152	130/9376	2.84696356275304	VEGFA/PIK3R1/GNAI1/COL4A1/ADCY3/COL4A2	2.72207974709788
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	10/152	300/9376	2.05614035087719	FLT1/VEGFA/PLA2G4A/PDGFD/INSR/PDGFRA/IGF1R/IL1R1/IGF2/DUSP1	2.38661740976883
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	6/152	138/9376	2.68192219679634	FOXO1/PRKAR2B/PIK3R1/INSR/IRS2/SORBS1	2.55507852252155
NA	NA	hsa04382	Cornified envelope formation	8/152	217/9376	2.27407227746786	S100A9/PCSK6/KRT8/KRT19/KRT7/COL4A1/COL4A2/COL17A1	2.43751719733962
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	6/152	139/9376	2.66262779250284	PIK3R1/NCOA1/FKBP5/KRT19/GNAI1/ADCY3	2.53503960805816
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	5/152	104/9376	2.96558704453441	PLA2G4A/PLA2G5/LPIN1/PLA2G2A/PLPP1	2.58743842972313
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	6/152	142/9376	2.60637509266123	VEGFA/PIK3R1/CTSL/IL1R1/DUSP1/GSTM3	2.47596204975098
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	4/152	71/9376	3.47516679021497	PRLR/PIK3R1/JAK2/FOXO3	2.68734385845488
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	3/152	41/9376	4.51347881899872	VEGFA/THBS1/CXCL8	2.89414237439023
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	6/152	144/9376	2.57017543859649	PIK3R1/JAK2/INHBA/IL6ST/IGF1R/ID4	2.43741406462111
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/152	42/9376	4.40601503759398	SAT1/SLC39A14/TF	2.83978259451578
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	5/152	109/9376	2.82955094157412	JAK2/IL6ST/IL1R1/GATA3/EBI3	2.46624352969692
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	5/152	109/9376	2.82955094157412	FOXO1/PIK3R1/INSR/IRS2/PTEN	2.46624352969692
Human Diseases	Cancer: specific types	hsa05214	Glioma	4/152	76/9376	3.24653739612188	PIK3R1/PDGFRA/IGF1R/PTEN	2.52421741800087
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	4/152	78/9376	3.16329284750337	CXCL8/GNAI1/SERPING1/ITGB1	2.46272335970883
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	5/152	115/9376	2.68192219679634	PLA2G4A/PTGS2/MAOA/GNAI1/DUSP1	2.32955873746871
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	3/152	47/9376	3.93729003359462	PIK3R1/INSR/IRS2	2.59134954857725
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	6/152	158/9376	2.34243837441706	PIK3R1/INSR/LPIN1/GRB10/IGF1R/PTEN	2.18450143757453
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	7/152	200/9376	2.15894736842105	LPAR1/CXCL8/TNFSF10/IL1R1/MYO1E/ITGB1/BAIAP2L1	2.12666847896368
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	7/152	201/9376	2.14820633673737	ZBTB16/FLT1/IGFBP3/FOXO1/CXCL8/IGF1R/AFF1	2.11233461835829
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/152	22/9376	5.60765550239234	AOC1/MAOA	2.7774128703748
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/152	23/9376	5.36384439359268	MME/ANPEP	2.68971021251234
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	9/152	298/9376	1.86294595549276	IL1RL1/PRLR/INHBA/BMP2/IL6ST/CXCL8/TNFSF10/IL1R1/EBI3	1.94332047057703
Organismal Systems	Immune system	hsa04611	Platelet activation	5/152	126/9376	2.44778613199666	PLA2G4A/PIK3R1/GNAI1/ADCY3/ITGB1	2.10022877074945
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	6/152	168/9376	2.20300751879699	PRLR/PIK3R1/JAK2/PDGFRA/IL6ST/FHL1	2.01970579826131
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	6/152	169/9376	2.18997197134849	PIK3R1/GABARAPL1/IRS2/CTSL/IGF1R/PTEN	2.00386655972693
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	6/152	170/9376	2.17708978328173	PIK3R1/IGF1R/TCF7L2/IGF2/PTEN/GSTM3	1.98813719621991
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	3/152	55/9376	3.36459330143541	CERS6/HEXB/PLPP1	2.2576381265058
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	4/152	95/9376	2.59722991689751	FLT1/VEGFA/CTSL/CXCL8	2.00853607986275
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	6/152	178/9376	2.07924305144885	NOTUM/DKK1/TCF7L2/SFRP1/PRICKLE2/MCC	1.86608037157671
Organismal Systems	Nervous system	hsa04730	Long-term depression	3/152	60/9376	3.08421052631579	PLA2G4A/IGF1R/GNAI1	2.07897973129381
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	4/152	98/9376	2.51772287862513	PLA2G4A/PIK3R1/ASAP1/PLPP1	1.93876923529941
Organismal Systems	Digestive system	hsa04978	Mineral absorption	3/152	61/9376	3.03364969801553	TF/MT2A/MT1E	2.04549027703724
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	4/152	99/9376	2.4922913343966	PLA2G4A/PIK3R1/IL1R1/ADCY3	1.91608698573203
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	9/152	323/9376	1.71875509206453	TIMP3/VEGFA/THBS1/PIK3R1/TPM1/IRS2/PDGFRA/PTGS2/PTEN	1.68746090730959
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	4/152	102/9376	2.41898864809082	PLA2G5/KCNMA1/PLA2G2A/ADCY3	1.84966571329078
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	5/152	144/9376	2.14181286549708	FOXO1/LPIN1/FOXO3/CXCL8/TCF7L2	1.77245845853732
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	4/152	103/9376	2.39550332141032	SERPINE1/PIK3R1/CXCL8/GNAI1	1.82804609292177
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	5/152	148/9376	2.08392603129445	PIK3R1/NCOA1/IGF1R/TCF7L2/PTEN	1.70617862227843
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	6/152	193/9376	1.91764385055904	PIK3R1/JAK2/FOXO3/CXCL8/GNAI1/ADCY3	1.65351563570464
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	3/152	68/9376	2.72136222910217	ZBTB16/PIK3R1/TCF7L2	1.8287162469277
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	4/152	110/9376	2.24306220095694	PIK3R1/IGF1R/GNAI1/ADCY3	1.68341363433646
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	3/152	71/9376	2.60637509266123	PIK3R1/PDGFRA/PTEN	1.74407731095289
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	4/152	112/9376	2.20300751879699	LAMB1/JAK2/GNAI1/ITGB1	1.64409104886419
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	2/152	36/9376	3.42690058479532	UGP2/GBE1	1.87274041784967
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	4/152	115/9376	2.14553775743707	PIK3R1/JAK2/GNAI1/ADCY3	1.58663551561474
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	7/152	253/9376	1.70667776159767	FOXO1/PIK3R1/FOXO3/CXCL8/IL1R1/ITGB1/ACTN1	1.46271809139212
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	4/152	116/9376	2.12704174228675	PIK3R1/GNAI1/ITGB1/ACTN1	1.56787446695227
NA	NA	hsa04519	Cadherin signaling	10/152	404/9376	1.52683689421574	TEAD1/KRT8/KRT19/PDGFRA/KRT7/IGF1R/TCF7L2/MYO1E/PRICKLE2/ACTN1	1.38953668167357
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	3/152	75/9376	2.46736842105263	GPX3/ALB/ADCY3	1.63776943957071
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/152	38/9376	3.24653739612188	HEXB/UGP2	1.78125583843666
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	2/152	38/9376	3.24653739612188	PIK3R1/INSR	1.78125583843666
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	5/152	166/9376	1.85795814838301	INSR/KCNMA1/IRS2/GNAI1/ADCY3	1.43165415232436
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	3/152	78/9376	2.37246963562753	FN1/PIK3R1/ITGB1	1.56243896246031
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/152	78/9376	2.37246963562753	JAK2/PTGS2/ITGB1	1.56243896246031
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	4/152	122/9376	2.02243313201035	FOXO1/PIK3R1/NCOA1/MED13L	1.45914303743528
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	6/152	216/9376	1.71345029239766	PIK3R1/JAK2/APOB/APOA1/CXCL8/TNFSF10	1.36172886692735
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	6/152	217/9376	1.7055542081009	VEGFA/PIK3R1/JAK2/GNAI1/ADCY3/GSTM3	1.34984533163163
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	4/152	125/9376	1.97389473684211	PIK3R1/CERS6/GNAI1/PTEN	1.40708544233706
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/152	42/9376	2.93734335839599	AOC1/MAOA	1.61527001145011
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	6/152	227/9376	1.63041966148852	MT-ATP8/VEGFA/PIK3R1/FOXO3/PTEN/GSTM3	1.23425145900374
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/152	45/9376	2.74152046783626	ABCA8/ABCA6	1.50320610265305
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	3/152	90/9376	2.05614035087719	PIK3R1/JAK2/PTEN	1.29233865801964
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	4/152	138/9376	1.78794813119756	FN1/PIK3R1/CXCL8/ITGB1	1.19700504025613
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	2/152	49/9376	2.51772287862513	MAOA/GNAI1	1.36731103092107
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	2/152	50/9376	2.46736842105263	THBS1/CXCL8	1.33543959944662
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	3/152	94/9376	1.96864501679731	S100A9/PTGS2/CXCL8	1.21158971596694
NA	NA	hsa04517	IgSF CAM signaling	7/152	299/9376	1.44411195212111	FOXO1/PIK3R1/NFASC/SORBS1/CLMP/ITGB1/ACTN1	1.00185454492922
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	3/152	98/9376	1.88829215896885	PIK3R1/IMPA2/PTEN	1.13472197989569
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	3/152	99/9376	1.86921850079745	PIK3R1/IGF1R/ADCY3	1.11606776689415
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/152	15/9376	4.11228070175439	HEXB	1.5484994368773
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	6/152	250/9376	1.48042105263158	HLA-G/RAB11FIP3/PDGFRA/ASAP1/IGF1R/WASHC2A	0.988324559608361
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	3/152	100/9376	1.85052631578947	IL6ST/CXCL8/TNFSF10	1.09762798324213
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	3/152	100/9376	1.85052631578947	IL1R1/MME/ANPEP	1.09762798324213
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	3/152	101/9376	1.83220427305888	TCF7L2/GNAI1/ADCY3	1.07939761512847
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/152	16/9376	3.85526315789474	MAOA	1.46729012110574
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/152	16/9376	3.85526315789474	HEXB	1.46729012110574
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	5/152	205/9376	1.50449293966624	PDK4/MT-ATP8/PIK3R1/INSR/PTEN	0.937500399650534
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	4/152	154/9376	1.60218728639781	PLA2G4A/PTGS2/GNAI1/ADCY3	0.967224232811979
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	3/152	105/9376	1.76240601503759	PTGS2/CXCL8/IL1R1	1.00847574653877
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	3/152	105/9376	1.76240601503759	GABARAPL1/FOXO3/BNIP3L	1.00847574653877
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	3/152	105/9376	1.76240601503759	TPM1/ADCY3/ITGB1	1.00847574653877
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/152	17/9376	3.62848297213622	GGT5	1.39239575311828
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/152	17/9376	3.62848297213622	GLUL	1.39239575311828
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	4/152	155/9376	1.5918505942275	HLA-G/THBS1/CTSL/ITGB1	0.953754743845893
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	4/152	157/9376	1.57157224270868	THBS1/JAK2/MFGE8/PTGS2	0.927100539308061
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	4/152	157/9376	1.57157224270868	SERPINE1/TEAD1/BMP2/TCF7L2	0.927100539308061
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	4/152	157/9376	1.57157224270868	PIK3R1/INSR/IRS2/CXCL8	0.927100539308061
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/152	18/9376	3.42690058479532	HEXB	1.32295326809711
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/152	19/9376	3.24653739612188	HEXB	1.25825864536663
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	2/152	63/9376	1.95822890559733	AASS/PLOD2	0.979585900991437
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	2/152	63/9376	1.95822890559733	BMP2/TCF7L2	0.979585900991437
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	1/152	20/9376	3.08421052631579	UGP2	1.19773092012126
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	2/152	65/9376	1.89797570850202	LPIN1/PLPP1	0.932547342011096
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	3/152	115/9376	1.6091533180778	GNAI1/GATA3/ADCY3	0.843712293760776
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	4/152	168/9376	1.46867167919799	GLUL/PLA2G4A/JAK2/TNFSF10	0.786843717239302
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	1/152	21/9376	2.93734335839599	UST	1.14088569486139
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	8/152	388/9376	1.27183939229517	MT-ATP8/PIK3R1/INSR/DKK1/SLC39A14/IRS2/PTGS2/MME	0.702011952633425
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	5/152	224/9376	1.37687969924812	HLA-G/PIK3R1/IL1R1/PTEN/ADCY3	0.732852431526707
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	2/152	69/9376	1.78794813119756	PLA2G4A/PIK3R1	0.843266996271434
Organismal Systems	Endocrine system	hsa04924	Renin secretion	2/152	69/9376	1.78794813119756	KCNMA1/GNAI1	0.843266996271434
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	4/152	173/9376	1.42622452083967	PIK3R1/JAK2/CXCL8/TNFSF10	0.726347685150564
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	3/152	120/9376	1.54210526315789	PIK3R1/FOXO3/IRAK3	0.767203117373409
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	1/152	23/9376	2.68192219679634	GLUL	1.03667383649532
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	2/152	70/9376	1.76240601503759	JAK2/IRS2	0.821867098730391
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/152	70/9376	1.76240601503759	PTGS2/GSTM3	0.821867098730391
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	2/152	70/9376	1.76240601503759	VEGFA/PIK3R1	0.821867098730391
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/152	73/9376	1.68997837058399	MAOA/GSTM3	0.759684352748629
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	2/152	73/9376	1.68997837058399	ELL2/SAMHD1	0.759684352748629
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	2/152	73/9376	1.68997837058399	PIK3R1/FOXO3	0.759684352748629
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	5/152	238/9376	1.29588677576294	PIK3R1/C7/IL6ST/CXCL8/RPS4Y1	0.593521208166536
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	2/152	75/9376	1.64491228070175	PIK3R1/GSTM3	0.719803976549727
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	2/152	76/9376	1.62326869806094	GNAI1/ADCY3	0.700306928545249
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	2/152	77/9376	1.60218728639781	VEGFA/PIK3R1	0.681093296787542
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	2/152	78/9376	1.58164642375169	IMPA2/PTEN	0.662154565211794
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	3/152	133/9376	1.39137316976652	HLA-G/PIK3R1/TNFSF10	0.583523268598051
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	1/152	29/9376	2.12704174228675	TEAD1	0.780280338958318
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	3/152	137/9376	1.35074913561275	PIK3R1/CTSL/TNFSF10	0.530874902794562
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/152	82/9376	1.50449293966624	HLA-G/CTSL	0.588990743941691
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	5/152	254/9376	1.21425611272275	FLT1/VEGFA/PDGFD/PDGFRA/ADCY3	0.444378287076016
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	3/152	140/9376	1.3218045112782	SERPINE1/GNAI1/ADCY3	0.492449803841386
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/152	31/9376	1.98981324278438	GLUL	0.70858546422305
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	1/152	32/9376	1.92763157894737	UGP2	0.674732895540305
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/152	32/9376	1.92763157894737	GABARAPL1	0.674732895540305
Human Diseases	Immune disease	hsa05310	Asthma	1/152	32/9376	1.92763157894737	PRG2	0.674732895540305
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	2/152	86/9376	1.43451652386781	PIK3R1/NRG2	0.519631476186778
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	2/152	86/9376	1.43451652386781	KCNMA1/ADCY3	0.519631476186778
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	2/152	86/9376	1.43451652386781	TCF7L2/ITGB1	0.519631476186778
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	2/152	87/9376	1.41802782819117	PIK3R1/TCF7L2	0.502838038617915
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	4/152	205/9376	1.20359435173299	HLA-G/PIK3R1/IL6ST/ACTN1	0.378339855940394
Human Diseases	Substance dependence	hsa05032	Morphine addiction	2/152	91/9376	1.3556969346443	GNAI1/ADCY3	0.437680955273888
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	3/152	149/9376	1.24196397032851	PTGS2/GNAI1/ADCY3	0.382174196400255
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	5/152	268/9376	1.15082482325216	MT-ATP8/SLC39A14/MAOA/GNAI1/DUSP1	0.321570718585171
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/152	36/9376	1.71345029239766	UGP2	0.550540556572674
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	1/152	36/9376	1.71345029239766	GALNT15	0.550540556572674
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	2/152	93/9376	1.32654216185625	JAK2/GATA3	0.406241556697938
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	2/152	93/9376	1.32654216185625	PLA2G4A/ADCY3	0.406241556697938
Organismal Systems	Digestive system	hsa04970	Salivary secretion	2/152	93/9376	1.32654216185625	KCNMA1/ADCY3	0.406241556697938
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	1/152	37/9376	1.66714082503556	GLUL	0.52193446668529
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/152	37/9376	1.66714082503556	MAOA	0.52193446668529
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/152	37/9376	1.66714082503556	UGP2	0.52193446668529
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	1/152	37/9376	1.66714082503556	APOA1	0.52193446668529
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	1/152	37/9376	1.66714082503556	TCF7L2	0.52193446668529
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	3/152	154/9376	1.20164046479836	TPM1/GNAI1/ADCY3	0.323871905425124
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	4/152	214/9376	1.15297589768815	HLA-G/PIK3R1/SAMHD1/GNAI1	0.290591253522762
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	3/152	155/9376	1.19388794567063	TCF7L2/GNAI1/ADCY3	0.312446333181873
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	1/152	38/9376	1.62326869806094	NNMT	0.494183185756164
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	2/152	97/9376	1.27183939229517	GNAI1/ADCY3	0.345458159938168
Human Diseases	Immune disease	hsa05330	Allograft rejection	1/152	39/9376	1.58164642375169	HLA-G	0.467235111383706
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	2/152	99/9376	1.2461456671983	TPM1/ITGB1	0.316048548056263
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	3/152	160/9376	1.15657894736842	HLA-G/NFASC/ITGB1	0.256430637728914
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/152	41/9376	1.50449293966624	MAOA	0.415563738814527
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	3/152	163/9376	1.13529221827575	PIK3R1/JAK2/CXCL8	0.223673157868225
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	2/152	105/9376	1.1749373433584	PIK3R1/PTGS2	0.231399102920468
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	1/152	44/9376	1.40191387559809	HEXB	0.343020249242941
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/152	44/9376	1.40191387559809	HLA-G	0.343020249242941
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	1/152	44/9376	1.40191387559809	ADCY3	0.343020249242941
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	1/152	45/9376	1.37076023391813	HLA-G	0.320024401975163
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	2/152	109/9376	1.13182037662965	PIK3R1/CXCL8	0.177694506098511
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	1/152	48/9376	1.28508771929825	PIK3R1	0.254186595674341
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	1/152	49/9376	1.25886143931257	GALNT15	0.233207330822347
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	3/152	180/9376	1.0280701754386	HLA-G/PIK3R1/JAK2	0.0488123462489203
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/152	51/9376	1.20949432404541	ADCY3	0.192566489695709
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	3/152	184/9376	1.00572082379863	PIK3R1/GNAI1/ITGB1	0.0100602844504943
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	2/152	119/9376	1.03670942061035	PIK3R1/PTGS2	0.0517325235221045
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	1/152	54/9376	1.14230019493177	HLA-G	0.134615668006311
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	3/152	187/9376	0.989586265128061	TXNIP/GABARAPL1/CXCL8	-0.0184646457125938
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	1/152	56/9376	1.1015037593985	CXCL8	0.0977948466195218
Cellular Processes	Cell motility	hsa04814	Motor proteins	3/152	194/9376	0.953879544221378	TPM1/MYO1E/ACTG2	-0.0833246688341034
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	2/152	133/9376	0.927582113177681	MAOA/GNAI1	-0.107972455160206
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	1/152	65/9376	0.948987854251012	ADCY3	-0.0529760888608649
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	1/152	65/9376	0.948987854251012	PIK3R1	-0.0529760888608649
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	2/152	138/9376	0.89397406559878	IGF1R/ADCY3	-0.161068442009295
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	1/152	66/9376	0.934609250398724	GATA3	-0.0684323143988606
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	2/152	142/9376	0.868791697553744	PIK3R1/IL1R1	-0.202235940381137
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	1/152	69/9376	0.89397406559878	MAOA	-0.113469615180764
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/152	143/9376	0.862716231137284	C7/ACTN1	-0.212355532119119
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	1/152	70/9376	0.881203007518797	HLA-G	-0.128062131754834
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	1/152	71/9376	0.868791697553744	CXCL8	-0.142455784051067
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	1/152	72/9376	0.85672514619883	CXCL8	-0.15665676584531
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	2/152	150/9376	0.822456140350877	PIK3R1/TCF7L2	-0.281379430463562
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	1/152	75/9376	0.822456140350877	GLUL	-0.198161486471252
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	3/152	226/9376	0.818816953889148	PIK3R1/GNAI1/ADCY3	-0.353923185718066
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	1/152	77/9376	0.801093643198906	PIK3R1	-0.224969522548439
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/152	79/9376	0.780812791472352	GSTM3	-0.251133772665817
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1/152	82/9376	0.752246469833119	GSTM3	-0.289249907330143
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	1/152	83/9376	0.743183259353202	SAMHD1	-0.301670048091855
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	1/152	87/9376	0.709013914095584	TPM1	-0.350021847431573
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	2/152	170/9376	0.725696594427245	ITGB1/ACTN1	-0.463306037835572
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	3/152	248/9376	0.746179966044143	CXCL8/TNFSF10/TCF7L2	-0.520010014654417
Organismal Systems	Digestive system	hsa04976	Bile secretion	1/152	90/9376	0.685380116959064	ADCY3	-0.384982390927224
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	1/152	91/9376	0.677848467322152	PIK3R1	-0.396403726971635
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	1/152	98/9376	0.629430719656283	ADCY3	-0.473372530911745
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	1/152	99/9376	0.623072833599149	KRT19	-0.48397067078162
Human Diseases	Substance dependence	hsa05034	Alcoholism	2/152	191/9376	0.645907963626343	MAOA/GNAI1	-0.634659883691416
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	1/152	107/9376	0.576487948844073	FOXO1	-0.5655734391202
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	3/152	275/9376	0.672918660287081	MT-ATP8/PIK3R1/C7	-0.706684136869368
NA	NA	hsa04082	Neuroactive ligand signaling	2/152	199/9376	0.619941814334832	GNAI1/ADCY3	-0.695623184394099
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	2/152	205/9376	0.601797175866496	HLA-G/PIK3R1	-0.739981231479888
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	1/152	117/9376	0.527215474583896	MORF4L2	-0.660574686280498
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	1/152	122/9376	0.505608283002589	PIK3R1	-0.705560304177566
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	1/152	128/9376	0.481907894736842	ADCY3	-0.757592791728982
Human Diseases	Infectious disease: viral	hsa05162	Measles	1/152	136/9376	0.453560371517028	PIK3R1	-0.823992845767669
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	1/152	138/9376	0.44698703279939	MT-ATP8	-0.840105183142007
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	2/152	235/9376	0.524972004479283	MT-ATP8/ADCY3	-0.946681885271917
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	1/152	144/9376	0.428362573099415	PIK3R1	-0.887363965797815
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	2/152	250/9376	0.493473684210526	HEXB/CTSL	-1.04202843576587
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	1/152	154/9376	0.400546821599453	UGP2	-0.962832749348588
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	1/152	156/9376	0.395411605937922	PIK3R1	-0.97747223397799
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	1/152	158/9376	0.390406395736176	CDKN1C	-0.991969635424663
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	3/152	368/9376	0.502860411899314	GPX3/MT-ATP8/NRG2	-1.24892354688983
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	3/152	370/9376	0.500142247510669	PRLR/LPAR1/ADM	-1.2592997231669
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	1/152	174/9376	0.354506957047792	UBXN4	-1.10324726772837
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	1/152	181/9376	0.340796743239314	JAK2	-1.14955710494121
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	4/152	480/9376	0.514035087719298	GPX3/MT-ATP8/DKK1/PTGS2	-1.40305898730551
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	1/152	195/9376	0.316329284750337	PIK3R1	-1.23841748323068
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	2/152	308/9376	0.400546821599453	GPX3/MT-ATP8	-1.37316477689916
Genetic Information Processing	Translation	hsa03010	Ribosome	1/152	222/9376	0.277856804172594	RPS4Y1	-1.3977906844668
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	1/152	449/9376	0.137381315203376	ADCY3	-2.40456792190899