category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	80/1435	205/9376	2.54977479391519	CD44/HLA-A/PIK3R1/BCL2/TNFAIP3/PLCG2/HLA-B/RUNX3/JAK1/HLA-C/NFKB1/RELB/BCL2L11/CCND3/CD58/TRAF3/MAP2K3/VIM/TRAF5/AKT3/STAT3/TAPBP/HLA-DPB1/NFKB2/HLA-F/CD247/CYCS/NFKBIA/CASP8/CDKN1A/CDKN1B/USP7/CASP3/RIPK1/STAT1/CCND2/MAPK8/MDM2/HLA-DRB1/TBK1/HLA-E/HLA-DQB1/GADD45B/SNW1/GADD45A/ITGAL/PIK3CB/DDB2/CDK6/HLA-DRB5/TAP1/PSMD7/EIF2AK2/MAPK14/IRF3/CIR1/IRAK4/OAS2/IRF9/SIN3A/IKBKB/TAB2/IFNAR2/CD3E/HLA-DPA1/PIK3CD/MYC/NCOR2/PDIA3/RELA/BID/MAP2K4/TP53/TYK2/PIK3R3/MAP2K7/HLA-DQA1/MAP3K14/HDAC1/TAP2	9.53698649455108
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	55/1435	122/9376	2.94556463129034	FYN/PIK3R1/CBLB/PTPRC/PRKCQ/VAV3/CARD11/NFKB1/ITK/PPP2R2B/RASGRP1/PPP2R5C/PPP3CC/MAPK1/AKT3/CD247/NFKBIA/PPP2R2A/PPP2R2D/MALT1/PPP2R5A/MAP2K1/RAF1/MAPK8/SOS2/KRAS/PPP2CA/PIK3CB/MAP2K2/LCK/MAP3K8/PPP2R3C/NCK1/MAPK14/IFNG/ZAP70/PTPN11/PAK2/IKBKB/PPP2R3A/NFATC2/CD3E/NFATC1/PIK3CD/NCK2/SOS1/PAK1/RELA/NFATC3/PIK3R3/MAP2K7/PPP3R1/MAP3K14/PPP2R5E/PPP2R1B	9.19464193023598
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	70/1435	196/9376	2.33349925335988	HLA-A/PIK3R1/PLCG2/HLA-B/CLEC2B/UBC/JAK1/HLA-C/NFKB1/ITPR1/PPP3CC/MAPK1/TCF7/TRAF3/GNB5/AKT3/STAT3/HLA-F/CYCS/NFKBIA/MAPKAPK2/CASP8/CDKN1A/CASP3/GNB1/PREX1/MAP2K1/STAT1/CALM1/PIK3R6/IFNGR1/RAF1/MAPK8/RPS27A/TBK1/KRAS/HLA-E/MAP1LC3B/PIK3CG/CREBBP/PIK3R5/PIK3CB/CDK6/MAP2K2/EIF2AK2/EP300/MAPK14/IRF3/PTGS2/VEGFA/BECN1/CREB1/ITPR3/IRF9/IKBKB/NFATC2/IFNAR2/NFATC1/PIK3CD/MYC/GNG4/RELA/BID/NFATC3/MAP2K4/TP53/TYK2/PIK3R3/MAP2K7/PPP3R1	8.01998327613441
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	66/1435	180/9376	2.39572590011614	HLA-A/CCL5/PIK3R1/BCL2/HLA-B/ZC3HAV1/TNFSF14/JAK1/HLA-C/NFKB1/PILRB/TRAF3/TRAF5/AKT3/BIRC3/TAPBP/HLA-DPB1/SRSF2/HLA-F/CYCS/NFKBIA/CASP8/BIRC2/ITGA5/CASP3/SP100/SRSF7/STAT1/IFNGR1/CGAS/HLA-DRB1/TBK1/HLA-E/HLA-DQB1/PIK3CB/HLA-DRB5/TAP1/EIF2AK2/FASLG/IFNG/IRF3/PTPN11/IRAK4/OAS2/NXF1/IRF9/SRSF4/IKBKB/SRPK1/PPP1CB/TAB2/IFNAR2/HLA-DPA1/PIK3CD/IFIH1/PDIA3/SRSF5/RELA/BID/POU2F1/TP53/TYK2/PIK3R3/HLA-DQA1/SRSF8/TAP2	8.03731333483396
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	59/1435	157/9376	2.45537628442708	ZFP36L2/HLA-A/PIK3R1/TGFB1/FOXO1/HLA-B/ETS1/HLA-C/NFKB1/KIR2DL4/ITPR1/RASSF5/PPP3CC/CCND3/MAPK1/MAP2K3/AKT3/SQSTM1/HIPK2/HLA-F/MAPKAPK2/SMAD3/HIPK1/CDKN1A/RRAS2/MAP2K1/CALM1/RAF1/CAPN2/CCND2/SERPINE1/MDM2/KRAS/HLA-E/GADD45B/GADD45A/LIN54/PIK3CB/CDK6/MAP2K2/MAPK14/FOXO3/RBL2/TRPM7/ITPR3/NFATC2/MCU/PPP1CB/NFATC1/PIK3CD/MYC/VDAC1/CDKN2A/RELA/NFATC3/TP53/PIK3R3/PPP3R1/RBBP4	7.81730763642903
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	37/1435	77/9376	3.13961717724784	PIK3R1/TGFB1/NFKB1/BRAF/BCR/MAPK1/AKT3/CTBP2/NFKBIA/SMAD3/CDKN1A/CDKN1B/MAP2K1/RAF1/MDM2/SOS2/KRAS/GADD45B/GADD45A/STAT5B/PIK3CB/DDB2/CDK6/MAP2K2/ABL1/PTPN11/IKBKB/PIK3CD/CBL/MYC/CRK/SOS1/CDKN2A/RELA/TP53/PIK3R3/HDAC1	8.01377796268022
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	74/1435	224/9376	2.15848680935789	HLA-A/PIK3R1/TGFB1/HLA-B/ETS1/IL2RG/JAK1/HLA-C/NFKB1/RELB/IL2RB/KAT2B/PPP3CC/CCND3/MAPK1/AKT3/XPO1/HLA-DPB1/NFKB2/HLA-F/NFKBIA/FOSL1/SMAD3/CDKN1A/TLN1/MAP2K1/BUB3/CCND2/MAPK8/POLB/HLA-DRB1/KRAS/HLA-E/HLA-DQB1/ELK4/TRRAP/STAT5B/CRTC3/CREBBP/ITGAL/PIK3CB/MAP2K2/LCK/HLA-DRB5/IL2RA/EP300/ANAPC16/TBPL1/ANAPC5/CREB1/RAN/IKBKB/NFATC2/PRKACB/CD3E/ADCY7/HLA-DPA1/XIAP/NFATC1/PIK3CD/MYC/VDAC1/IL15/MAD1L1/CDKN2A/RELA/NFATC3/MAP2K4/FDPS/TP53/PIK3R3/PPP3R1/HLA-DQA1/MAP3K14	7.45986704779404
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	74/1435	227/9376	2.12996055196549	CXCR4/HLA-A/CCL5/PIK3R1/HLA-B/PTK2B/JAK1/HLA-C/NFKB1/ITPR1/AKAP13/PPP3CC/MAPK1/TRAF5/GNB5/AKT3/STAT3/TAPBP/HLA-F/CYCS/NFKBIA/CASP8/CDKN1A/CASP3/GNB1/PTGER4/ARHGEF1/RIPK1/MAP2K1/CCL4/CALM1/RAF1/CGAS/MDM2/SOS2/TBK1/KRAS/HLA-E/PIK3CB/RPS6KB1/CDK6/MAP2K2/RAC2/CCL4L2/TAP1/FASLG/MAPK14/IRF3/PTGS2/VEGFA/CREB1/ITPR3/IKBKB/NFATC2/PRKACB/ADCY7/NFATC1/PIK3CD/MYC/CRK/SOS1/GNA13/GNG4/CDKN2A/PDIA3/RELA/IL10RA/BID/NFATC3/TP53/PIK3R3/PPP3R1/ROCK1/TAP2	7.32594050918538
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	45/1435	109/9376	2.6974395038839	TGFB1/HSP90AA1/PRKCQ/RORA/IL2RG/JAK1/NFKB1/IL2RB/HSP90AB1/PPP3CC/GATA3/MAPK1/STAT3/IRF4/HLA-DPB1/CD247/NFKBIA/SMAD3/IL4R/IL21R/STAT1/RARA/IFNGR1/MAPK8/HLA-DRB1/HLA-DQB1/STAT5B/LCK/HLA-DRB5/TBX21/IL2RA/MAPK14/IFNG/ZAP70/IKBKB/NFATC2/CD3E/HLA-DPA1/NFATC1/RELA/IL27RA/NFATC3/TYK2/PPP3R1/HLA-DQA1	7.57725605310089
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	51/1435	133/9376	2.50544130360745	FYN/HLA-A/PIK3R1/PLCG2/KLRC3/HLA-B/KLRD1/KLRK1/KLRC1/VAV3/PTK2B/HLA-C/KLRC2/SH2D1A/KIR2DL4/BRAF/LAT2/PPP3CC/MAPK1/CD48/SH2D1B/CD247/CASP3/MAP2K1/IFNGR1/NCR1/RAF1/PRF1/SOS2/KRAS/HLA-E/ITGAL/PIK3CB/MAP2K2/RAC2/LCK/FASLG/IFNG/ZAP70/KIR3DL2/PTPN11/NFATC2/IFNAR2/NFATC1/PIK3CD/SOS1/PAK1/BID/ICAM2/PIK3R3/PPP3R1	7.43288069395645
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	70/1435	214/9376	2.13722361522681	CXCR4/HLA-A/PIK3R1/BCL2/PLCG2/HLA-B/APOBEC3G/PTK2B/HLA-C/NFKB1/ITPR1/TNFRSF1B/PPP3CC/MAPK1/MAP2K3/TRAF5/GNB5/AKT3/TAPBP/HLA-F/CD247/CYCS/NFKBIA/CASP8/CUL1/CASP3/GNB1/RIPK1/AP1G1/MAP2K1/CALM1/RAF1/CGAS/MAPK8/TBK1/KRAS/HLA-E/PIK3CB/RPS6KB1/MAP2K2/RAC2/TAP1/RNF7/FASLG/MAPK14/IRF3/APOBEC3C/PAK2/IRAK4/ITPR3/IKBKB/NFATC2/AP1S3/TAB2/CD3E/NFATC1/PIK3CD/CRK/APOBEC3F/PAK1/GNG4/PDIA3/RELA/BID/NFATC3/PIK3R3/MAP2K7/PPP3R1/SKP1/TAP2	7.1537144910893
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	58/1435	163/9376	2.3249096855561	STAT4/PIK3R1/BCL2/TGFB1/PTK2B/JAK1/NFKB1/BRAF/MAPK1/TRAF3/MAP2K3/AKT3/STAT3/YWHAZ/CYCS/NFKBIA/CASP8/SMAD3/CDKN1A/CASP3/MAP2K1/STAT1/RAF1/YWHAQ/MAPK8/SOS2/TBK1/KRAS/STAT5B/CREBBP/PIK3CB/DDB2/MAP2K2/FASLG/CASP10/EP300/MAPK14/DDX3X/IRF3/CREB1/IRAK4/SLC10A1/IKBKB/NFATC2/TAB2/NFATC1/PIK3CD/MYC/IFIH1/SOS1/RELA/BID/NFATC3/MAP2K4/TP53/TYK2/PIK3R3/MAP2K7	7.25359882374455
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	40/1435	93/9376	2.81023565996029	STAT4/PRKCQ/RUNX3/IL2RG/JAK1/NFKB1/IL2RB/PPP3CC/GATA3/MAPK1/HLA-DPB1/CD247/NFKBIA/IL12RB2/IL4R/STAT1/IFNGR1/MAPK8/HLA-DRB1/HLA-DQB1/STAT5B/LCK/HLA-DRB5/TBX21/IL2RA/MAPK14/IFNG/ZAP70/IKBKB/NFATC2/MAML1/CD3E/HLA-DPA1/NFATC1/RELA/NFATC3/TYK2/PPP3R1/HLA-DQA1/MAML3	7.45772569879222
Human Diseases	Infectious disease: viral	hsa05162	Measles	51/1435	136/9376	2.45017421602787	PIK3R1/BCL2/TNFAIP3/CBLB/IL2RG/JAK1/NFKB1/IL2RB/HSPA1B/HSPA8/HSPA6/CCND3/TRAF3/AKT3/STAT3/MSN/CYCS/NFKBIA/CASP8/CDKN1B/CASP3/HSPA1A/STAT1/CCND2/MAPK8/TBK1/EIF3H/STAT5B/PIK3CB/CDK6/EIF2AK2/FASLG/IL2RA/IRF3/CD46/IRAK4/OAS2/ADAR/IRF9/IKBKB/TAB2/IFNAR2/CD3E/MX1/PIK3CD/IFIH1/RELA/BID/TP53/TYK2/PIK3R3	7.24148505037217
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	60/1435	173/9376	2.26605707840728	CCL5/PIK3R1/DNAJB1/JAK1/NFKB1/HNRNPUL1/NUP98/RAB11A/CCND3/MAPK1/TRAF3/AKT3/NXT1/XPO1/HLA-DPB1/CYCS/NFKBIA/CASP8/CASP3/MAP2K1/STAT1/IFNGR1/RAF1/HLA-DRB1/TBK1/HLA-DQB1/CREBBP/KPNA1/PIK3CB/DNAJC3/CDK6/MAP2K2/HLA-DRB5/EIF2AK2/FASLG/IL18/EP300/IFNG/IRF3/IRAK4/OAS2/NXF1/ADAR/IRF9/IKBKB/KPNA2/IFNAR2/HLA-DPA1/MX1/PIK3CD/IFIH1/VDAC1/RELA/BID/FDPS/TYK2/PIK3R3/HLA-DQA1/KPNA5/CALCOCO2	7.14472663646928
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	43/1435	105/9376	2.67574581051933	PIK3R1/CBLB/PLCG2/IRF1/CYLD/NFKB1/RELB/ITPR1/PPP3CC/MAPK1/AKT3/KSR1/NFKB2/NFKBIA/MAPKAPK2/CASP8/LSP1/MALT1/RRAS2/STAT1/CALM1/RAF1/MAPK8/MDM2/KRAS/PIK3CB/MAPK14/PTGS2/PTPN11/ITPR3/BCL3/IRF9/IKBKB/NFATC2/NFATC1/PIK3CD/PAK1/RELA/NFATC3/PIK3R3/PPP3R1/PLK3/MAP3K14	7.34029462549144
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	37/1435	83/9376	2.9126568993745	SFMBT2/AUTS2/JARID2/EZH2/OGT/KDM2B/L3MBTL4/PCGF5/RYBP/YAF2/USP7/FOXK2/UBE2D3/ASXL1/LCOR/CBX3/ASXL2/PHF1/CREBBP/USP16/KDM2A/PHF19/EP300/MTF2/MAX/UBE2D2/BCOR/AEBP2/FBRS/CBX4/TEX10/EED/TFDP1/HDAC1/RBBP4/DCAF7/SKP1	7.43998636684762
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	42/1435	103/9376	2.6642671086905	SMG1/GSPT1/MSI2/PPP2R2B/PPP2R5C/ETF1/NXT1/DDX39B/PPP2R2A/RBM8A/PPP2R2D/SRRM1/RNPS1/WDR33/PPP2R5A/PAPOLG/SMG6/FUS/CPSF6/PABPC1/CASC3/PPP2CA/RNMT/SYMPK/CPSF7/PPP2R3C/EIF4A3/TARDBP/NXF1/PPP2R3A/PAPOLA/RNGTT/PPP1CB/SMG5/PNN/WDR82/UPF1/PABPC4/DDX19B/DDX19A/PPP2R5E/PPP2R1B	7.2194731140577
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	50/1435	137/9376	2.38459777715608	TUBA4A/PIK3R1/BCL2/MCL1/LMNA/NFKB1/ITPR1/BCL2L11/MAPK1/AKT3/BIRC3/SPTAN1/CFLAR/CYCS/NFKBIA/CASP8/BIRC2/ERN1/EIF2AK3/CASP3/TRAF1/RIPK1/MAP2K1/LMNB1/RAF1/CAPN2/CTSW/MAPK8/PRF1/KRAS/GADD45B/DDIT3/GADD45A/PIK3CB/MAP2K2/PARP4/FASLG/CASP10/ITPR3/IKBKB/PARP1/XIAP/PIK3CD/RELA/BID/TP53/PIK3R3/MAP3K14/MAP3K5/NTRK1	6.93977549104995
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	66/1435	205/9376	2.10356420498003	HLA-A/PIK3R1/REL/HLA-B/RASA2/JAK1/HLA-C/NFKB1/KAT2B/ACTN4/CHD4/CCND3/MAPK1/TRAF3/TRAF5/STAT3/YWHAZ/NFKB2/HLA-F/NFKBIA/HDAC4/MAPKAPK2/CASP8/CDKN1A/CDKN1B/USP7/CASP3/SP100/TRAF1/UBR4/GTF2B/CCND2/YWHAQ/ACTN1/POLB/MDM2/KRAS/HLA-E/SNW1/PKM/STAT5B/CREBBP/PIK3CB/CDK6/EIF2AK2/EP300/DDX3X/IRF3/TBPL1/CREB1/YWHAG/RBL2/IRF9/SND1/PRKACB/GTF2A1/HDAC5/PIK3CD/UBE3A/MAD1L1/CDKN2A/RELA/TP53/PIK3R3/HDAC1/GTF2H1	6.79110084903118
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	76/1435	253/9376	1.96272190164025	CD44/FNBP1/CCL5/PIK3R1/BCL2/PLCG2/FOXO1/PRKCQ/UBC/SEPTIN6/DIAPH1/NFKB1/CAST/ITPR1/ACTN4/CYTH1/MYL9/MAPK1/TRAF5/AKT3/SQSTM1/PRKCE/CYCS/NFKBIA/CYTH3/TLN1/ATG16L1/CUL1/ITGA5/ITGB1/MALT1/RIPK1/UBE2D3/RPS6KA5/CAPN2/CGAS/CBX3/MAPK8/RPS27A/ACTN1/MDM2/TBK1/MAP1LC3B/ARF6/PIK3CB/RPS6KB1/ATG12/SEPTIN11/RBCK1/IL18/MAPK14/HCLS1/IRF3/UBE2N/BECN1/FOXO3/ARPC5L/ITPR3/SEPTIN7/IKBKB/UBE2D2/ATG5/TAB2/GLMN/PIK3CD/CRK/VDAC1/RELA/TNIP1/SEPTIN9/TP53/PIK3R3/ROCK1/SKP1/ELMO2/CALCOCO2	6.59881975490029
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	43/1435	112/9376	2.50851169736187	BCL2/TGFB1/JAK1/NFKB1/SOCS1/LDLR/HSPA1B/HSPA8/HSPA6/MAPK1/MAP2K3/AKT3/BIRC3/STAT3/HLA-DPB1/CYCS/NFKBIA/CASP8/BIRC2/ITGB1/CASP3/HSPA1A/STAT1/PIK3R6/IFNGR1/MAPK8/HLA-DRB1/HLA-DQB1/PIK3CG/PIK3R5/HLA-DRB5/MAPK14/IFNG/IRAK4/IKBKB/TAB2/PPIF/HLA-DPA1/XIAP/RELA/IL10RA/TYK2/HLA-DQA1	6.82703942781868
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	45/1435	120/9376	2.45017421602787	PIK3R1/BCL2/PLCG2/NFKB1/BRAF/ARHGDIB/RPS6KA3/MATK/MAPK1/AKT3/NFKBIA/MAPKAPK2/RAP1B/RAPGEF1/PSEN1/RPS6KA5/MAP2K1/CALM1/RAF1/MAPK8/SOS2/KRAS/PIK3CB/MAP2K2/CAMK4/ABL1/ARHGDIA/FASLG/MAPK14/PTPN11/FOXO3/IRAK4/IKBKB/ZNF274/IRAK2/PIK3CD/CRK/RAP1A/SOS1/RELA/TP53/PIK3R3/MAP2K7/MAP3K5/NTRK1	6.79630905793434
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	50/1435	142/9376	2.30063306669284	CBLB/UBC/SOCS1/UBE2S/BIRC3/UBR5/HERC1/UBE2G1/FBXW7/BIRC2/CUL3/CUL1/HUWE1/UBE2H/UBE2D3/MGRN1/UBE2B/RPS27A/MDM2/UBE2O/FBXW8/DDB2/SMURF2/UBE2R2/BIRC6/RNF7/UBE4A/CUL2/ANAPC16/UBE2N/ANAPC5/UBE2F/UBE3C/UBE2I/UBE2D2/UBE2A/UBE2L6/SAE1/XIAP/HERC3/ITCH/CBL/UBE3A/UBE2Q2/UBA6/TRIP12/VHL/SMURF1/UBE2J1/SKP1	6.63862319374566
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	56/1435	169/9376	2.1650454611055	PIK3R1/BCL2/GABARAPL1/PRKCQ/DDIT4/UBC/ITPR1/MAPK1/EPG5/AKT3/SQSTM1/CFLAR/OPTN/ERN1/ATG16L1/RB1CC1/EIF2AK3/RRAS2/PLEKHM1/MAP2K1/RAF1/MAPK8/RPS27A/TBK1/KRAS/MAP1LC3B/ATG4B/PPP2CA/PIK3CB/RPS6KB1/IRS2/AMBRA1/MAP2K2/ATG12/BIRC6/SH3GLB1/RUBCN/DAPK2/PRKAA1/BECN1/ATG101/IGF1R/ATG5/ATG13/PRKACB/TAX1BP1/WDR45B/ATG2A/VMP1/PIK3CD/ULK1/STX17/PIK3R3/ATG2B/MTMR3/CALCOCO2	6.4968246265866
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	44/1435	119/9376	2.41585805053729	CCL5/PIK3R1/TNFAIP3/IRF1/CYLD/NFKB1/TNFRSF1B/MAPK1/IL18R1/TRAF3/MAP2K3/TRAF5/AKT3/BIRC3/CFLAR/NFKBIA/CASP8/BIRC2/CASP3/TRAF1/RIPK1/RPS6KA5/MAP2K1/MAPK8/PIK3CB/MAP3K8/CASP10/MAPK14/PTGS2/CREB1/BCL3/IKBKB/LIF/TAB2/XIAP/PIK3CD/ITCH/IL15/RELA/MAP2K4/PIK3R3/MAP2K7/MAP3K14/MAP3K5	6.60742213797738
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	33/1435	77/9376	2.80019910403186	PIK3R1/TGFB1/JAK1/NFKB1/BRAF/MAPK1/AKT3/STAT3/SMAD3/CDKN1A/RALGDS/MAP2K1/STAT1/RAF1/MAPK8/KRAS/GADD45B/GADD45A/PIK3CB/DDB2/RPS6KB1/CDK6/RAC2/RALA/TGFA/VEGFA/IKBKB/PIK3CD/CDKN2A/RELA/TP53/PIK3R3/ARHGEF6	6.74251266148632
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	47/1435	133/9376	2.30893610332451	PIK3R1/TGFB1/FOXO1/GABARAPL1/STK4/BCL6/HOMER1/BRAF/BCL2L11/MAPK1/AKT3/STAT3/FBXO32/SMAD3/CDKN1A/CDKN1B/USP7/MAP2K1/RAF1/CCND2/MAPK8/PRKAG2/MDM2/SOS2/KRAS/GADD45B/GADD45A/CREBBP/PIK3CB/IRS2/MAP2K2/ATG12/FASLG/EP300/MAPK14/AGAP2/PRKAA1/FOXO3/RBL2/IGF1R/IKBKB/CSNK1E/PIK3CD/SOS1/SOD2/PIK3R3/PLK3	6.46266703903341
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	34/1435	82/9376	2.70913571853489	HLA-A/KLRC3/HLA-B/KLRD1/KLRC1/HSP90AA1/HLA-C/KLRC2/HSPA1B/KIR2DL4/HSPA8/HSPA4/HSPA6/HSP90AB1/TAPBP/HLA-DPB1/HLA-F/PSME1/HSPA1A/PSME2/HLA-DRB1/HLA-E/HLA-DQB1/KLRC4/HLA-DRB5/TAP1/IFNG/KIR3DL2/HSPA5/CREB1/HLA-DPA1/PDIA3/HLA-DQA1/TAP2	6.60778849217569
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	35/1435	87/9376	2.62853938884216	PIK3R1/BCL2/TGFB1/AREG/BRAF/BCL2L11/MAPK1/TCF7/AKT3/CYCS/SMAD3/CDKN1A/CASP3/RALGDS/MAP2K1/RAF1/MAPK8/SOS2/KRAS/GADD45B/AXIN1/GADD45A/PIK3CB/DDB2/RPS6KB1/MAP2K2/RAC2/MLH1/RALA/TGFA/PIK3CD/MYC/SOS1/TP53/PIK3R3	6.48705235098118
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	30/1435	70/9376	2.80019910403186	PIK3R1/TGFB1/ETS1/BRAF/MAPK1/AKT3/CDKN1A/RAP1B/RAPGEF1/MAP2K1/RAF1/SOS2/KRAS/CREBBP/PIK3CB/MAP2K2/EP300/CUL2/PTPN11/TGFA/VEGFA/PAK2/PIK3CD/CRK/RAP1A/SOS1/PAK1/VHL/PIK3R3/EGLN1	6.42631526943483
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	55/1435	174/9376	2.06528094837599	BCL2/DNAJB1/HSPH1/HSP90AA1/HSPA1B/NFE2L2/HSPA8/HSPA6/HSP90AB1/STT3B/CRYAB/DNAJA1/PPP1R15A/DNAJC1/UBE2G1/ERN1/ERO1B/CUL1/EIF2AK3/SEC23B/HSPA1A/UBE2D3/MAGT1/SSR4/UBXN2A/CAPN2/MAPK8/DDIT3/UBXN4/SVIP/DNAJC3/SAR1A/UBQLN1/SEC24A/SSR2/SEC13/HSPA5/ERO1A/NGLY1/UBE2D2/ERP29/BCAP31/HERPUD1/SEC24B/OS9/HYOU1/DERL1/PDIA3/BAG1/XBP1/MAP2K7/MAP3K5/UBE2J1/UGGT1/SKP1	6.02936617926832
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	35/1435	90/9376	2.54092140921409	PIK3R1/PRKCQ/EML4/JAK1/NFKB1/RASGRP1/PPP3CC/MAPK1/MAP2K3/AKT3/STAT3/CD247/NFKBIA/MAP2K1/STAT1/IFNGR1/RAF1/KRAS/PIK3CB/RPS6KB1/MAP2K2/LCK/MAPK14/IFNG/ZAP70/PTPN11/IKBKB/NFATC2/CD3E/NFATC1/PIK3CD/RELA/NFATC3/PIK3R3/PPP3R1	6.24397844242083
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	71/1435	250/9376	1.85559860627178	CXCR4/HLA-A/CBLB/VPS37B/HLA-B/IL2RG/HLA-C/ARAP2/IL2RB/LDLR/HSPA1B/RAB11FIP1/HSPA8/HSPA6/SMAP2/CYTH1/RAB11A/AP2B1/ACAP1/STAM/GBF1/IGF2R/WIPF3/HLA-F/DNM2/CYTH3/SMAD3/ARFGAP3/HSPA1A/CHMP4A/RAB11FIP3/GRK5/WIPF1/SMAP1/SH3KBP1/MDM2/HLA-E/ZFYVE27/IST1/USP8/ARF6/ARF4/SMURF2/PIP5K1A/AGAP3/SH3GLB1/IL2RA/WIPF2/EHD1/ARFGEF1/AGAP2/ARPC5L/GRK2/IGF1R/PSD4/KIF5B/CHMP4B/ITCH/CBL/CHMP1B/VPS4B/PIP5K1C/VPS26A/RAB35/ARFGEF2/CHMP2B/SMURF1/SH3GL1/PSD/WASHC2A/RAB22A	5.828728564182
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	46/1435	138/9376	2.17793263646922	PIK3R1/VAV3/PTK2B/NFKB1/ITGA4/ARHGEF7/RPS6KA3/MAPK1/MAP2K3/AKT3/WIPF3/NFKBIA/ITGA5/ITGB1/ARHGEF1/WIPF1/MAP2K1/MAPK8/TBK1/ARF6/PIK3CB/MAP2K2/RAC2/LCK/PIP5K1A/IL18/MAPK14/WIPF2/ZAP70/IRF3/IRAK4/ARPC5L/IKBKB/NFATC2/TAB2/NFATC1/PIK3CD/CRK/PIP5K1C/RELA/NFATC3/MAP2K4/PIK3R3/MAP2K7/ROCK1/ELMO2	5.92577298482152
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	30/1435	73/9376	2.6851224285237	PIK3R1/PLCG2/EML4/STK4/BRAF/RASSF5/MAPK1/AKT3/STAT3/CDKN1A/MAP2K1/RASSF1/RAF1/SOS2/KRAS/GADD45B/GADD45A/STAT5B/PIK3CB/DDB2/CDK6/MAP2K2/TGFA/FOXO3/KIF5B/PIK3CD/SOS1/CDKN2A/TP53/PIK3R3	6.14405888410502
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	50/1435	156/9376	2.09416599660502	PIK3R1/JAK1/NFKB1/LDLR/BRAF/PPP2R2B/MAPK1/TRAF3/AKT3/STAT3/YWHAZ/CFLAR/CYCS/NFKBIA/PPP2R2A/CASP8/CDKN1A/PPP2R2D/CASP3/RIPK1/MAP2K1/STAT1/RAF1/YWHAQ/SOS2/TBK1/KRAS/PPP2CA/PIK3CB/CDK6/MAP2K2/EIF2AK2/FASLG/IFNG/IRF3/YWHAG/OAS2/IRF9/IKBKB/IFNAR2/MX1/PIK3CD/MYC/SOS1/RELA/BID/TP53/TYK2/PIK3R3/PPP2R1B	5.85806307427197
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	63/1435	216/9376	1.90569105691057	CCL5/PIK3R1/BCL2/HSPD1/HSP90AA1/VAV3/NFKB1/LDLR/HSPA1B/ITPR1/NFE2L2/HSPA8/HSPA4/HSPA6/HSP90AB1/PPP3CC/MAPK1/TRAF3/MAP2K3/AKT3/STAT3/CYCS/NFKBIA/CASP8/ERN1/RAP1B/EIF2AK3/CASP3/HSPA1A/ARHGEF1/CALM1/MAPK8/TBK1/KRAS/DDIT3/PIK3CB/ABCG1/FASLG/IL18/MAPK14/IRF3/HSPA5/IRAK4/ERO1A/IKBKB/NFATC2/TAB2/NFATC1/PIK3CD/RAP1A/SOD2/RELA/BID/POU2F1/NFATC3/MAP2K4/TP53/XBP1/PIK3R3/MAP2K7/APOB/PPP3R1/MAP3K5	5.72444265119062
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	87/1435	333/9376	1.70702828263804	HLA-A/PIK3R1/FOXO1/IRF1/HLA-B/JAK1/HLA-C/NFKB1/ITGA4/PPP2R2B/PPP2R5C/CHD4/CCND3/MAPK1/TCF7/TRAF3/AKT3/OASL/HLA-F/PPP2R2A/PATJ/CASP8/CDKN1A/CDKN1B/ITGA5/PPP2R2D/ITGB1/CASP3/PSEN1/PTGER4/LLGL2/PPP2R5A/UBR4/MAP2K1/STAT1/RAF1/CCND2/MDM2/SOS2/TBK1/TNC/KRAS/HLA-E/AXIN1/PPP2CA/PKM/CREBBP/PIK3CB/RPS6KB1/CDK6/MAP2K2/PPP2R3C/EIF2AK2/FASLG/EP300/IRF3/TBPL1/PTGS2/VEGFA/CREB1/RBL2/IRF9/IKBKB/PPP2R3A/MAML1/BCAP31/PRKACB/IFNAR2/THBS1/LFNG/MX1/NFX1/PIK3CD/UBE3A/COL4A4/SOS1/RELA/TP53/TYK2/DLG3/CSNK1A1/PIK3R3/HES4/HDAC1/PPP2R5E/MAML3/PPP2R1B	5.58440142068164
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	80/1435	300/9376	1.74234610917538	DUSP2/TGFB1/NR4A1/AREG/RASA2/DUSP4/DUSP10/STK4/DUSP16/NFKB1/RELB/HSPA1B/BRAF/HSPA8/PPM1B/RPS6KA3/HSPA6/RASGRP1/FLNA/JUND/PPP3CC/MAPK1/PTPN7/MAP2K3/AKT3/NFKB2/MAPKAPK2/DUSP5/RAP1B/CASP3/HSPB1/HSPA1A/RRAS2/RPS6KA5/MAP2K1/RAF1/MAPK8/SOS2/KRAS/GADD45B/DDIT3/ELK4/GADD45A/MAP2K2/RAC2/PDGFD/MAP3K8/FASLG/MAPK14/MAP3K2/FLT3LG/TGFA/VEGFA/PAK2/IRAK4/MAX/IGF1R/IKBKB/RASA1/MKNK2/PRKACB/TAB2/RAPGEF2/NFATC1/MYC/CRK/RAP1A/SOS1/PAK1/RELA/MAP3K4/NFATC3/MAP2K4/TP53/MAP2K7/PPP3R1/TAOK1/MAP3K14/MAP3K5/NTRK1	5.55512468447783
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	46/1435	142/9376	2.11658242135741	FYN/PIK3R1/PLCG2/TGFB1/FOSL2/CYLD/JAK1/NFKB1/RELB/SOCS1/ITPR1/JUND/PPP3CC/MAPK1/AKT3/SQSTM1/NFKB2/NFKBIA/FOSL1/ATP2A3/MAP2K1/STAT1/IFNGR1/MAPK8/ATP2A2/PIK3CB/LCK/CAMK4/MAPK14/IFNG/CREB1/FOSB/ITPR3/IRF9/IKBKB/NFATC2/TAB2/IFNAR2/NFATC1/PIK3CD/RELA/TYK2/PIK3R3/MAP2K7/PPP3R1/MAP3K14	5.69920152729946
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	38/1435	108/9376	2.29892889405085	RANBP2/NUP98/NXT1/DDX39B/XPO1/NUP88/RBM8A/XPO6/SENP2/SRRM1/RNPS1/POM121/TNPO3/NUP153/RANGAP1/CASC3/NUP210/KPNA1/TPR/EIF4A3/SEC13/NUP58/AHCTF1/NXF1/RAN/UBE2I/KPNA4/TNPO1/KPNA2/PNN/THOC1/IPO5/UPF1/THOC2/DDX19B/DDX19A/KPNA5/POM121C	5.77136090841672
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	42/1435	125/9376	2.19535609756098	FYN/PIK3R1/BCL2/NFKB1/PPP2R2B/PPP2R5C/MAPK1/AKT3/PRKCE/PPP2R2A/PPP2R2D/PPP2R5A/MAP2K1/ABCC1/RAF1/MAPK8/KRAS/PPP2CA/PIK3CB/MAP2K2/RAC2/PPP2R3C/CERS5/MAPK14/ORMDL2/CERS6/CERS4/PPP2R3A/SPTLC1/SPHK1/SGMS2/PIK3CD/SPTLC2/GNA13/RELA/BID/TP53/PIK3R3/ROCK1/MAP3K5/PPP2R5E/PPP2R1B	5.7191561993755
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	32/1435	86/9376	2.43118061745401	PIK3R1/CBLB/PLCG2/AREG/BRAF/MAPK1/AKT3/CDKN1A/CDKN1B/MAP2K1/RAF1/MAPK8/SOS2/KRAS/STAT5B/PIK3CB/RPS6KB1/MAP2K2/ABL1/NCK1/TGFA/PAK2/PIK3CD/CBL/MYC/CRK/NCK2/SOS1/PAK1/MAP2K4/PIK3R3/MAP2K7	5.66773851126655
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	27/1435	68/9376	2.59430211108834	PIK3R1/ZBTB16/NFKB1/BRAF/MAPK1/TCF7/AKT3/STAT3/MAP2K1/RARA/RAF1/PER2/SOS2/KRAS/STAT5B/PIK3CB/RPS6KB1/MAP2K2/PIM2/PPARD/IKBKB/PIK3CD/PIM1/MYC/SOS1/RELA/PIK3R3	5.60881196982406
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	36/1435	105/9376	2.24015928322549	BCL2/TNFAIP3/PLCG2/TNFSF14/PRKCQ/CARD11/CYLD/CCL21/NFKB1/RELB/TRAF3/TRAF5/BIRC3/CFLAR/NFKB2/NFKBIA/BIRC2/TRAF1/MALT1/RIPK1/CCL4/GADD45B/GADD45A/LCK/CCL4L2/ZAP70/PTGS2/IRAK4/UBE2I/IKBKB/PARP1/TAB2/XIAP/ERC1/RELA/MAP3K14	5.43228839616923
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	28/1435	73/9376	2.50611426662212	CXCR4/RANBP2/APOBEC3G/ELL2/KAT2B/XPO1/MLLT3/CHMP4A/CCNT1/ELL/MDFIC/TNPO3/NUP153/CPSF6/CREBBP/CPSF7/EP300/CCNT2/APOBEC3C/AFF4/RAN/CHMP4B/SUPT5H/MX1/APOBEC3F/VPS4B/MAP1B/PSIP1	5.49138423635123
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	54/1435	187/9376	1.88676517170061	CCL5/BCL2/TNFAIP3/GABARAPL1/HSP90AA1/JAK1/NFKB1/ITPR1/HSP90AB1/MAPK1/TRAF3/TRAF5/BIRC3/NFKBIA/CASP8/GBP5/BIRC2/GBP2/ATG16L1/RIPK1/NLRP1/STAT1/TP53BP1/NEK7/MAPK8/TBK1/MAP1LC3B/GBP4/TXN/ATG12/RBCK1/IL18/MAPK14/IRF3/IRAK4/OAS2/TRPM7/ITPR3/GBP3/IRF9/TRPV2/ERBIN/IKBKB/ATG5/MCU/TAB2/IFNAR2/XIAP/GBP1/VDAC1/RELA/TXNIP/TYK2/PSTPIP1	5.20678081294086
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	26/1435	66/9376	2.57392038855453	STAT4/TGFB1/RORA/IL2RG/NFKB1/GATA3/IL18R1/STAT3/HLA-DPB1/SMAD3/IL12RB2/IL4R/IL21R/STAT1/IFNGR1/HLA-DRB1/HLA-DQB1/IL18RAP/HLA-DRB5/TBX21/IL18/IFNG/HLA-DPA1/NFATC1/RELA/HLA-DQA1	5.45448660127392
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	66/1435	248/9376	1.73883331460043	TUBA4A/BCL2/PTPRC/RHOH/HSP90AA1/NFKB1/AHNAK/DYNC1H1/FLNA/CYTH1/HSP90AB1/MYL9/MAPK1/TCF7/MAP2K3/AKT3/BIRC3/CYFIP2/CYCS/NFKBIA/RPS3/DNM2/CYTH3/CASP8/BIRC2/CASP3/TUBB4B/RIPK1/PLEKHM1/MAP2K1/RAF1/MAPK8/DYNLT1/ARF6/KLC1/TXN/PIK3CG/KPNA1/PIK3CB/MAP2K2/EXOC2/GAPDH/ABI1/IL18/MAPK14/GCC2/RALA/IRAK4/ARPC5L/IKBKB/KPNA4/ARL8B/TAB2/KIF5B/PIK3CD/MYC/DCTN3/PAK1/ANXA2/RELA/MAP2K4/ACTR10/ACTR1B/MAP2K7/SKP1/ELMO2	5.01254731786022
Human Diseases	Cancer: specific types	hsa05214	Glioma	28/1435	76/9376	2.40718870346598	PIK3R1/PLCG2/BRAF/MAPK1/CAMK1D/AKT3/CDKN1A/MAP2K1/CALM1/RAF1/MDM2/SOS2/KRAS/GADD45B/GADD45A/PIK3CB/DDB2/CDK6/MAP2K2/CAMK4/TGFA/IGF1R/PIK3CD/SOS1/CDKN2A/TP53/PIK3R3/CAMK1	5.23590372830538
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	36/1435	110/9376	2.13833386126069	PIK3R1/BCL2/PLCG2/NFKB1/PFKFB3/MAPK1/AKT3/STAT3/PGK1/LDHA/CDKN1A/CDKN1B/TIMP1/MAP2K1/PFKP/IFNGR1/SERPINE1/ENO1/CREBBP/PIK3CB/RPS6KB1/MAP2K2/GAPDH/EP300/IFNG/CUL2/VEGFA/IGF1R/MKNK2/PDHA1/TF/PIK3CD/RELA/VHL/PIK3R3/EGLN1	5.10497759158318
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	23/1435	59/9376	2.54707376129451	PIK3R1/BRAF/MAPK1/TCF7/AKT3/CDKN1A/MAP2K1/RAF1/SOS2/KRAS/GADD45B/AXIN1/GADD45A/PIK3CB/DDB2/MAP2K2/MLH1/FOXO3/PIK3CD/MYC/SOS1/TP53/PIK3R3	5.06725744293818
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	53/1435	193/9376	1.79425538444874	CXCR4/CCL5/XCL1/PIK3R1/PLCG2/VAV3/XCL2/PTK2B/CCL21/NFKB1/ITK/BRAF/TIAM1/MAPK1/GNB5/AKT3/STAT3/CCL14/NFKBIA/RAP1B/GNB1/PREX1/GRK5/MAP2K1/STAT1/CCL4/PIK3R6/RAF1/SOS2/KRAS/STAT5B/PIK3CG/PIK3R5/PIK3CB/RAC2/CCL4L2/CXCR3/FOXO3/GRK2/IKBKB/PRKACB/ADCY7/PIK3CD/CRK/RAP1A/SOS1/PAK1/GNG4/RELA/CCL28/PIK3R3/CCL18/ROCK1	4.73936896996781
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	34/1435	106/9376	2.09574649924397	PIK3R1/BCL2/FOXO1/HSP90AA1/ZEB1/NFKB1/BRAF/HSP90AB1/MAPK1/TCF7/AKT3/NFKBIA/CDKN1A/CDKN1B/MAP2K1/RAF1/MDM2/SOS2/KRAS/CREBBP/PIK3CB/MAP2K2/PDGFD/EP300/GSTP1/TGFA/CREB1/IGF1R/IKBKB/PIK3CD/SOS1/RELA/TP53/PIK3R3	4.82277663381286
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	31/1435	93/9376	2.17793263646922	PIK3R1/BCL2/NFKB1/TRAF3/TRAF5/AKT3/BIRC3/CYCS/NFKBIA/BIRC2/CDKN1A/CDKN1B/ITGB1/CASP3/TRAF1/GADD45B/CKS2/GADD45A/PIK3CB/DDB2/CDK6/PTGS2/MAX/IKBKB/XIAP/PIK3CD/MYC/COL4A4/RELA/TP53/PIK3R3	4.85279275441702
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	45/1435	158/9376	1.86089180964142	TGFB1/PPP2R5C/CCNH/CCND3/YWHAZ/SMAD3/CDKN1A/CDC14A/CDKN1B/STAG2/CUL1/PPP2R5A/BUB3/CCND2/YWHAQ/MDM2/DBF4/GADD45B/ESCO1/PPP2CA/GADD45A/CREBBP/CDK6/PRKDC/ABL1/EP300/ANAPC16/ANAPC5/WAPL/NIPBL/YWHAG/RBL2/PDS5A/MYC/MAD1L1/CDKN2A/TFDP2/MCM6/TP53/TFDP1/HDAC1/PDS5B/PPP2R5E/SKP1/PPP2R1B	4.63908957574343
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	30/1435	90/9376	2.17793263646922	PIK3R1/FOXO1/NFKB1/AKT3/RB1CC1/EHMT1/PRKAG2/ADIPOR2/KRAS/SESN1/PIK3CB/RPS6KB1/IRS2/CAMK4/PRKAA1/FOXO3/CREB1/ATG101/IGF1R/ATG5/ATG13/PRKACB/ADCY7/SESN2/PIK3CD/SOD2/RELA/ULK1/TP53/PIK3R3	4.77310909223396
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	23/1435	62/9376	2.42382825671575	PIK3R1/FOXO1/HSPA1B/HSPA8/HSPA6/CRYAB/AKT3/HSPA1A/PRKAG2/KRAS/PIK3CB/RPS6KB1/IRS2/PRKAA1/FOXO3/IGF1R/ATG5/PRKACB/ADCY7/PIK3CD/SOD2/PIK3R3/HDAC1	4.78144677976171
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	26/1435	75/9376	2.26504994192799	PIK3R1/BCL2/TOP2B/MAPK1/AKT3/BIRC3/CYCS/CASP8/BIRC2/CDKN1A/CASP3/ERCC1/MDM2/PIK3CB/POLH/FASLG/MLH1/GSTP1/XIAP/PIK3CD/CDKN2A/BID/TP53/PIK3R3/REV3L/MAP3K5	4.67570896682513
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	25/1435	71/9376	2.30063306669284	PIK3R1/IRF1/NFKB1/SOCS1/MAPK1/AKT3/STAT3/MAP2K1/STAT1/RAF1/CCND2/MAPK8/SOS2/KRAS/STAT5B/PIK3CB/MAP2K2/MAPK14/FOXO3/SOCS2/PIK3CD/SOCS4/SOS1/RELA/PIK3R3	4.67627203306365
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	59/1435	232/9376	1.66161239937522	CXCR4/PIK3R1/EZR/RGCC/PIP4K2A/VAV3/MYH9/DIAPH1/ITGAE/ITGA4/BRAF/MYH11/ARHGEF7/ACTN4/TIAM1/MYL9/MAPK1/SPATA13/AKT3/MSN/CYFIP2/SLC9A1/FGD3/ITGA5/ITGB1/SSH1/ARHGEF1/RRAS2/MAP2K1/SSH2/IQGAP2/RAF1/ACTN1/IQGAP1/SOS2/KRAS/ITGAX/ITGAL/PIK3CB/MAP2K2/RAC2/PDGFD/PIP5K1A/ITGAD/PPP1R12A/PAK2/ARPC5L/F2R/PPP1CB/PIK3CD/CRK/MYLK/PIP5K1C/SOS1/PAK1/GNA13/PIK3R3/ARHGEF6/ROCK1	4.33764005120664
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	22/1435	60/9376	2.39572590011614	PIK3R1/PLCG2/SH2D2A/PPP3CC/MAPK1/AKT3/MAPKAPK2/HSPB1/MAP2K1/RAF1/KRAS/PIK3CB/MAP2K2/RAC2/MAPK14/PTGS2/VEGFA/NFATC2/SPHK1/PIK3CD/PIK3R3/PPP3R1	4.61036185821328
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	60/1435	238/9376	1.64717594354815	PIK3R1/PLCG2/REL/RALGAPA1/RASA2/ETS1/STK4/NFKB1/RASSF5/TIAM1/RASGRP1/MAPK1/GNB5/AKT3/KSR1/RASA3/RAP1B/GNB1/RALGDS/RRAS2/MAP2K1/PLA2G6/RASSF1/CALM1/RAF1/MAPK8/PLAAT3/SOS2/TBK1/KRAS/ARF6/PIK3CB/MAP2K2/RAC2/EXOC2/PDGFD/ABL1/RASAL3/FASLG/ZAP70/FLT3LG/RALA/PTPN11/TGFA/VEGFA/PAK2/RALGAPA2/IGF1R/IKBKB/RALGAPB/RASA1/PRKACB/PIK3CD/RAP1A/SOS1/PAK1/GNG4/RELA/PIK3R3/NTRK1	4.29891895754994
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	53/1435	204/9376	1.69750631960101	CD44/PIK3R1/PLCG2/EZR/TGFB1/VAV3/PDCD4/BRAF/ITPR1/TIAM1/FLNA/MAPK1/AKT3/STAT3/MSN/SLC9A1/CDKN1A/ITGA5/ITGB1/CASP3/ARHGEF1/RRAS2/DDX5/MAP2K1/RAF1/IQGAP1/MDM2/SOS2/KRAS/PIK3CB/RPS6KB1/MAP2K2/FASLG/MAPK14/PPP1R12A/HCLS1/PTPN11/SDC4/VEGFA/ITPR3/IGF1R/PRKACB/PPP1CB/THBS1/EIF4B/PIK3CD/CBL/MYC/SOS1/PAK1/TP53/PIK3R3/ROCK1	4.28159119071239
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	29/1435	91/9376	2.08219933376728	PIK3R1/PLCG2/IFITM1/VAV3/CARD11/NFKB1/PPP3CC/MAPK1/AKT3/INPP5D/NFKBIA/MALT1/MAP2K1/RAF1/PIK3AP1/SOS2/KRAS/PIK3CB/MAP2K2/RAC2/IKBKB/NFATC2/NFATC1/PIK3CD/SOS1/RELA/NFATC3/PIK3R3/PPP3R1	4.40971980443881
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	33/1435	109/9376	1.97812230284819	CCL5/PIK3R1/JAK1/NFKB1/MAPK1/TRAF3/MAP2K3/AKT3/NFKBIA/CASP8/RIPK1/MAP2K1/STAT1/CCL4/MAPK8/TBK1/PIK3CB/MAP2K2/CCL4L2/MAP3K8/MAPK14/IRF3/IRAK4/IRF9/IKBKB/TAB2/IFNAR2/PIK3CD/RELA/MAP2K4/TYK2/PIK3R3/MAP2K7	4.36627233133864
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	26/1435	78/9376	2.17793263646922	BTG1/CNOT6L/HSPD1/TENT4B/CNOT2/HSPA9/DHX36/TENT4A/DDX6/BTG3/TOB2/PFKP/BTG2/PABPC1/CNOT1/ENO1/MTREX/XRN1/CNOT6/XRN2/CNOT9/ZCCHC7/CNOT10/CNOT4/PABPC4/LSM2	4.44065440999242
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	15/1435	34/9376	2.88255790120926	BHLHE40/RORA/CSNK1D/PER1/CRY1/CUL1/PER2/PRKAG2/NFIL3/NR1D2/PRKAA1/RORB/CREB1/CSNK1E/SKP1	4.67457207447305
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	24/1435	70/9376	2.24015928322549	FYN/HLA-A/HLA-B/HLA-C/HLA-DPB1/HLA-F/CYCS/CASP8/CD55/CASP3/PRF1/HLA-DRB1/HLA-E/HLA-DQB1/SNTB2/ITGAL/RAC2/HLA-DRB5/ABL1/SNTB1/HLA-DPA1/BID/HLA-DQA1/EIF4G2	4.4270961586826
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	45/1435	168/9376	1.75012444001991	STAT4/PIK3R1/BCL2/MCL1/IL2RG/JAK1/IL2RB/SOCS1/CCND3/STAM/AKT3/STAT3/IL12RB2/CDKN1A/IL4R/IL21R/STAT1/IFNGR1/RAF1/CCND2/SOS2/STAT5B/CREBBP/PIK3CB/IL2RA/EP300/IFNG/PTPN11/IRF9/SOCS2/CSF3/LIF/IFNAR2/PIK3CD/SOCS4/PIM1/CLCF1/MYC/IL15/SOS1/IL10RA/IL27RA/TYK2/PIK3R3/IL9R	4.17041517156385
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	52/1435	203/9376	1.6736822230995	FYN/PIK3R1/BCL2/VAV3/DIAPH1/ITGA4/BRAF/ACTN4/FLNA/MYL9/CCND3/MAPK1/AKT3/BIRC3/BIRC2/EMP1/TLN1/RAP1B/ITGA5/ITGB1/RAPGEF1/MAP2K1/RAF1/CAPN2/CCND2/MAPK8/ACTN1/SOS2/TNC/PIK3CB/RAC2/PDGFD/PIP5K1A/PPP1R12A/VEGFA/PAK2/IGF1R/PPP1CB/PARVG/THBS1/XIAP/PIK3CD/CRK/RAP1A/MYLK/COL4A4/PIP5K1C/SOS1/PAK1/ZYX/PIK3R3/ROCK1	4.12497575627509
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	34/1435	117/9376	1.89871050358855	GATAD2B/CHD3/CHD4/SMARCA2/GATAD2A/BAZ1A/ARID2/INO80D/EPC1/BICRAL/SMARCA5/TRRAP/DPF3/BAZ1B/EP400/SRCAP/SMARCA4/PHF6/SMARCC1/MBD2/BAZ2A/BRD7/ARID1A/MORF4L2/SS18/SS18L1/CHRAC1/MORF4L1/ARID1B/UCHL5/BRD9/HDAC1/RBBP4/PBRM1	4.15819351764611
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	23/1435	69/9376	2.17793263646922	FYN/PIK3R1/PLCG2/VAV3/MAPK1/MAP2K3/AKT3/INPP5D/ALOX5AP/MAP2K1/RAF1/MAPK8/SOS2/KRAS/PIK3CB/MAP2K2/RAC2/MAPK14/PIK3CD/SOS1/MAP2K4/PIK3R3/MAP2K7	4.17459293607287
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	38/1435	138/9376	1.79916174317023	PIK3R1/CBLB/FOXO1/SOCS1/BRAF/PRKAR2A/MAPK1/AKT3/SORBS1/RHOQ/RAPGEF1/INPP5A/MAP2K1/PRKAR2B/CALM1/RAF1/MAPK8/PRKAG2/SOS2/KRAS/PIK3CB/RPS6KB1/IRS2/MAP2K2/PTPN1/PRKAA1/SOCS2/IKBKB/MKNK2/PRKACB/PPP1CB/PPP1R3B/PIK3CD/CBL/SOCS4/CRK/SOS1/PIK3R3	4.02030720735934
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	32/1435	110/9376	1.9007412100095	SKI/TGFB1/SKIL/SMAD7/MAPK1/TGIF2/ID2/SMAD3/GREM2/CUL1/NCOR1/PPP2CA/CREBBP/RPS6KB1/SMURF2/LEMD3/EP300/IFNG/SIN3A/BMP8A/THBS1/TGIF1/TF/MYC/EMP3/TFDP1/SMURF1/ROCK1/HDAC1/ACVR1B/SKP1/PPP2R1B	4.03946842784903
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	39/1435	144/9376	1.76957026713124	PIK3R1/RORA/ITPR1/ATXN1/AKT3/CYCS/ERN1/RB1CC1/ATP2A3/GTF2B/MAPK8/ATP2A2/PIK3CB/AMBRA1/ATXN2L/PUM1/OPA1/PSMD7/TBPL1/BECN1/PSMA7/ITPR3/ATG101/MCU/ATG13/PPIF/ATG2A/PUM2/PIK3CD/VDAC1/ATXN2/NOP56/ULK1/XBP1/PIK3R3/ATG2B/PSMA6/MAP3K5/PSMA5	3.95599395191445
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	40/1435	149/9376	1.75403970722353	FYN/PIK3R1/PLCG2/PTK2B/DGKD/CYTH1/MAPK1/AGPAT4/AKT3/DNM2/CYTH3/RALGDS/RRAS2/MAP2K1/PIK3R6/RAF1/SOS2/KRAS/ARF6/PIK3CG/PIK3R5/PIK3CB/MAP2K2/PDGFD/PIP5K1A/DGKA/RALA/PTPN11/F2R/SPHK1/ADCY7/PLPP1/PIK3CD/AGPAT5/DGKZ/PIP5K1C/SOS1/GNA13/DGKE/PIK3R3	3.94394709652885
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	15/1435	37/9376	2.6488369903004	BRAF/MAPK1/TCF7/CDKN1A/MAP2K1/KRAS/GADD45B/GADD45A/DDB2/MAP2K2/TPR/CCDC6/MYC/TP53/NTRK1	4.2717161529744
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	16/1435	41/9376	2.54977479391519	BRAF/MAPK1/CDKN1A/RPS6KA5/MAP2K1/RASSF1/RAF1/MDM2/KRAS/MAP2K2/VEGFA/DAPK2/THBS1/MYC/CDKN2A/TP53	4.22743901354777
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	17/1435	45/9376	2.46832365466512	HLA-A/HLA-B/KLRD1/KLRC1/HLA-C/HLA-DPB1/HLA-F/PRF1/HLA-DRB1/HLA-E/HLA-DQB1/HLA-DRB5/FASLG/IFNG/KIR3DL2/HLA-DPA1/HLA-DQA1	4.19699013320899
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	30/1435	103/9376	1.90304793477893	CCL5/PIK3R1/TGFB1/NFKB1/PPP2R2B/MAPK1/AKT3/CFLAR/CD247/NFKBIA/PPP2R2A/CASP8/PPP2R2D/IFNGR1/SERPINE1/MAPK8/PPP2CA/PIK3CB/FASLG/MAPK14/IFNG/IRAK4/IKBKB/CD3E/PIK3CD/RELA/GNAL/MAP2K4/PIK3R3/PPP2R1B	3.9173581282704
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	80/1435	362/9376	1.4439332396481	PIK3R1/BCL2/MCL1/NR4A1/AREG/HSP90AA1/DDIT4/IL2RG/JAK1/NFKB1/IL2RB/ITGA4/PPP2R2B/PPP2R5C/HSP90AB1/BCL2L11/CCND3/MAPK1/GNB5/AKT3/YWHAZ/PPP2R2A/CDKN1A/IL4R/CDKN1B/ITGA5/PPP2R2D/ITGB1/GNB1/PPP2R5A/MAP2K1/PIK3R6/RAF1/CCND2/YWHAQ/MDM2/PIK3AP1/SOS2/TNC/KRAS/PPP2CA/PHLPP1/PIK3CG/PIK3R5/PIK3CB/RPS6KB1/CDK6/MAP2K2/PDGFD/PPP2R3C/FASLG/IL2RA/FLT3LG/TGFA/VEGFA/PRKAA1/CDC37/FOXO3/CREB1/YWHAG/RBL2/F2R/IGF1R/IKBKB/CSF3/PPP2R3A/IFNAR2/THBS1/EIF4B/PIK3CD/MYC/COL4A4/SOS1/GNG4/RELA/TP53/PIK3R3/PPP2R5E/PPP2R1B/NTRK1	3.66173712579176
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	49/1435	201/9376	1.592816405776	REL/ZBTB16/FOXO1/ZEB1/RUNX2/BCL6/NFKB1/IL2RB/KDM6A/BIRC3/ID2/BIRC2/CDKN1A/CDKN1B/MLLT3/TRAF1/NCOR1/CCNT1/DDX5/NSD2/RARA/FUS/CCND2/PER2/MDM2/TAF15/KMT2A/GADD45B/DDIT3/ELK4/GADD45A/NR4A3/DDB2/SUPT3H/BCL11B/CCNT2/MAX/SIN3A/IGF1R/ATF1/SS18/MYC/DOT1L/RELA/TP53/SS18L1/EWSR1/HDAC1/NTRK1	3.61151311990078
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	28/1435	98/9376	1.8667994026879	PIK3R1/PLCG2/PIP4K2A/ITPR1/DGKD/ITPKB/SACM1L/INPP5D/INPP5A/INPP4A/PI4KA/CALM1/IP6K1/PIK3CB/PIP5K1A/ITPK1/ITPKC/DGKA/ITPR3/PI4K2B/CDS2/PIK3CD/DGKZ/PIP5K1C/MTMR1/DGKE/PIK3R3/MTMR3	3.66672591386885
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	40/1435	157/9376	1.66466188774718	DUSP2/TGFB1/DUSP4/DUSP16/ATP8A1/ATP11B/MFGE8/MAPK1/MAPKAPK2/XKR6/ODC1/DUSP5/CASP3/PTGER4/ATP2A3/GPR132/SLC16A1/MAP2K1/PLA2G6/CPT1A/ATP2A2/MAP2K2/NR1H2/MAPK14/PTGS2/PTPN11/CREB1/DNMT3A/PPARD/NFATC2/SPHK1/THBS1/ATP11C/ADAM10/NFATC1/CRK/RAB14/NFATC3/HAVCR2/UQCRFS1	3.57011894884264
NA	NA	hsa04517	IgSF CAM signaling	67/1435	299/9376	1.46409518371342	FYN/TUBA4A/PIK3R1/PLCG2/CD96/EZR/FOXO1/MBP/PRKCQ/VAV3/MYH9/NCAM1/ITGA4/SH2D1A/ICAM3/MYH11/ACTN4/CASK/MYL9/MAPK1/CD2/AKT3/CD48/SPTAN1/SORBS1/MSN/SH2D1B/INPP5D/CRTAM/RAP1B/ITGA5/ITGB1/TIGIT/TUBB4B/MAP2K1/RAPGEF6/SLAMF7/MAPK8/PLXNA4/ACTN1/IQGAP1/ARF6/ITGAX/ITGAL/PIK3CB/MAP2K2/LCK/DOK2/ABL1/NCK1/MAPK14/SRGAP3/PTPN11/PAK2/ARPC5L/RASA1/CD2AP/RAPGEF2/PIK3CD/NCK2/ERC1/RAP1A/MYLK/PAK1/ICAM2/CABLES1/PIK3R3	3.46693323772442
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	24/1435	80/9376	1.9601393728223	PIK3R1/BCL2/PLCG2/JAK1/BRAF/BCL2L11/MAPK1/AKT3/STAT3/MAP2K1/RAF1/SOS2/KRAS/PIK3CB/RPS6KB1/MAP2K2/PDGFD/TGFA/VEGFA/FOXO3/IGF1R/PIK3CD/SOS1/PIK3R3	3.66610758917468
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	28/1435	99/9376	1.84794284306479	PIK3R1/GPCPD1/DGKD/MAPK1/CHKA/AKT3/RALGDS/MAP2K1/RAF1/MAPK8/SOS2/KRAS/PIK3CB/RPS6KB1/MAP2K2/RAC2/PDGFD/CHPT1/PIP5K1A/DGKA/PLPP1/PIK3CD/DGKZ/PIP5K1C/SOS1/DGKE/PCYT1A/PIK3R3	3.6054077560001
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	30/1435	109/9376	1.79829300258927	PIK3R1/FOXO1/PRKCQ/NFKB1/RPS6KA3/OGT/AKT3/STAT3/GFPT1/PRKCE/NFKBIA/OGA/CPT1A/MAPK8/PRKAG2/PIK3CB/RPS6KB1/IRS2/PTPN1/NR1H2/PTPN11/MLXIP/PRKAA1/CREB1/IKBKB/PPP1CB/PPP1R3B/PIK3CD/RELA/PIK3R3	3.56352640089807
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	48/1435	200/9376	1.56811149825784	FYN/TUBA4A/EZR/MYH9/NFKB1/MYH11/CYTH1/MAPK1/CYFIP2/WIPF3/CYCS/NFKBIA/RPS3/CYTH3/CASP8/ITGB1/CASP3/TUBB4B/ARHGEF1/RIPK1/MYO1D/WIPF1/MAPK8/ARF6/ABL1/NCK1/GAPDH/FASLG/ABI1/SEC24A/IL18/MAPK14/WIPF2/HCLS1/PTPN11/PAK2/IRAK4/ARPC5L/F2R/IKBKB/NCL/TAB2/SEC24B/NCK2/PAK1/GNA13/RELA/ROCK1	3.45219934129262
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	22/1435	72/9376	1.99643825009679	CYLD/RNF125/NFKB1/TRAF3/NFKBIA/CASP8/RIPK1/MAPK8/TBK1/ZNFX1/ATG12/CASP10/MAPK14/DDX3X/IRF3/ADAR/IKBKB/ATG5/OTUD5/IFIH1/RELA/SIKE1	3.60791068954178
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	42/1435	170/9376	1.61423242467719	PIK3R1/PLCG2/TGFB1/BRAF/NFE2L2/SMARCA2/MAPK1/TCF7/AKT3/SMAD3/CDKN1A/ARID2/MAP2K1/RAF1/TXNRD1/SOS2/KRAS/GADD45B/AXIN1/DPF3/GADD45A/PIK3CB/DDB2/RPS6KB1/CDK6/MAP2K2/SMARCA4/SMARCC1/GSTP1/TGFA/BRD7/ARID1A/IGF1R/PIK3CD/MYC/SOS1/CDKN2A/TP53/CSNK1A1/PIK3R3/ARID1B/PBRM1	3.43554550099693
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	36/1435	140/9376	1.68011946241911	ITPR1/MAPK1/ACTA2/GNB5/AKT3/PRKCE/HDAC4/SLC9A1/SMAD3/MEF2D/GNB1/RRAS2/MAP2K1/CALM1/PIK3R6/RAF1/SERPINE1/PRKAG2/KRAS/MAP1LC3B/PIK3CG/PIK3R5/RPS6KB1/MAP2K2/CAMK4/PRKAA1/BECN1/NRF1/ITPR3/PRKACB/SPHK1/ADCY7/HDAC5/MYLK/GNA13/GNG4	3.44652354166971
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	28/1435	101/9376	1.81134991547935	PIK3R1/BCL2/PLCG2/TGFB1/FOXO1/DIAPH1/NFKB1/MAPK1/AKT3/STAT3/PRKCE/SMAD3/CDKN1B/CASP3/STAT1/SERPINE1/MAPK8/KRAS/STAT5B/PIK3CB/MAPK14/VEGFA/NFATC1/PIK3CD/PIM1/COL4A4/RELA/PIK3R3	3.4848646395463
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	32/1435	122/9376	1.71378305820529	PIK3R1/FOXO1/PFKFB3/PPP2R2B/PPP2R5C/AKT3/PPP2R2A/PPP2R2D/PPP2R5A/PFKP/CPT1A/TBC1D1/PRKAG2/ADIPOR2/PPP2CA/CAB39/PIK3CB/RPS6KB1/IRS2/PPP2R3C/PRKAA1/FOXO3/CREB1/IGF1R/PPP2R3A/PIK3CD/STRADA/RAB14/ULK1/PIK3R3/PPP2R5E/PPP2R1B	3.37330332311485
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	32/1435	122/9376	1.71378305820529	PIK3R1/PLCG2/FOXO1/KAT2B/ATP1B3/MAPK1/AKT3/SLC9A1/ATP1A1/ATP2A3/NCOR1/MED14/MAP2K1/STAT1/PFKP/MED13/RAF1/NCOA3/ATP2A2/MDM2/KRAS/CREBBP/PIK3CB/MAP2K2/EP300/SIN3A/PRKACB/PIK3CD/MYC/TP53/PIK3R3/HDAC1	3.37330332311485
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/1435	56/9376	2.10014932802389	HSPD1/NFKB1/HSPA1B/HSPA8/CLK1/HSPA6/NFKB2/CYCS/NFKBIA/CASP8/CASP3/HSPA1A/BCL2L13/SAR1A/HSF1/IL18/CLK4/RELA	3.51003693051288
Human Diseases	Immune disease	hsa05330	Allograft rejection	14/1435	39/9376	2.34546591619762	HLA-A/HLA-B/HLA-C/HLA-DPB1/HLA-F/PRF1/HLA-DRB1/HLA-E/HLA-DQB1/HLA-DRB5/FASLG/IFNG/HLA-DPA1/HLA-DQA1	3.5791122186969
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	26/1435	94/9376	1.8072206983468	TNFAIP3/HSP90AA1/NFKB1/JUND/HSP90AB1/MAPK1/TRAF3/TRAF5/NFKBIA/FOSL1/CASP8/CASP3/MAPK8/TBK1/USP25/MAPK14/IFNG/PTGS2/ANAPC5/MAPK6/FOSB/IKBKB/CSF3/TAB2/IL17RA/RELA	3.34356233904775
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	27/1435	99/9376	1.78194488438391	PIK3R1/BCL2/BRAF/MAPK1/AKT3/CDKN1A/CDKN1B/NCOR1/MAP2K1/RAF1/NCOA3/MAPK8/MDM2/SOS2/KRAS/PIK3CB/RPS6KB1/MAP2K2/MAPK14/IGF1R/PRKACB/ADCY7/PIK3CD/SOS1/CDKN2A/TP53/PIK3R3	3.32478795473119
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	9/1435	20/9376	2.94020905923345	SC5D/CYP51A1/LBR/SOAT1/CYP2R1/FDFT1/HSD17B7/LSS/DHCR7	3.69226114481493
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	15/1435	44/9376	2.22743110547989	CCNH/MNAT1/TAF4B/GTF2B/TAF15/TAF3/TAF10/TBPL1/TAF11/TAF2/GTF2F2/GTF2A1/GTF2F1/TAF7/GTF2H1	3.46904624103358
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	15/1435	44/9376	2.22743110547989	HLA-A/HSPD1/HLA-B/HLA-C/HLA-DPB1/HLA-F/PRF1/HLA-DRB1/HLA-E/HLA-DQB1/HLA-DRB5/FASLG/IFNG/HLA-DPA1/HLA-DQA1	3.46904624103358
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	21/1435	71/9376	1.93253177602199	PIK3R1/SLC7A5/SLC16A3/MAPK1/GLS/AKT3/LDHA/MAP2K1/PFKP/RAF1/KRAS/PKM/PIK3CB/MAP2K2/PDHA1/PIK3CD/SLC1A5/MYC/TP53/PIK3R3/NTRK1	3.35280747185911
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	12/1435	32/9376	2.45017421602787	BCL2/BCL2L11/BIRC3/CYCS/CASP8/BIRC2/CASP3/MAPK8/BIRC6/BECN1/XIAP/BID	3.4930334467167
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	40/1435	168/9376	1.55566616890659	STAT4/BCL2/TNFAIP3/HSP90AA1/CYLD/JAK1/HSP90AB1/TRAF5/GLUD1/ZBP1/BIRC3/STAT3/SQSTM1/CFLAR/CASP8/BIRC2/CHMP4A/RIPK1/STAT1/IFNGR1/CAPN2/MAPK8/SPATA2L/STAT5B/EIF2AK2/FASLG/RBCK1/IFNG/TRPM7/IRF9/PARP1/IFNAR2/CHMP4B/XIAP/CHMP1B/VPS4B/VDAC1/BID/TYK2/CHMP2B	3.08929891828519
Human Diseases	Cancer: specific types	hsa05218	Melanoma	21/1435	73/9376	1.87958569996659	PIK3R1/BRAF/MAPK1/AKT3/CDKN1A/MAP2K1/RAF1/MDM2/KRAS/GADD45B/GADD45A/PIK3CB/DDB2/CDK6/MAP2K2/PDGFD/IGF1R/PIK3CD/CDKN2A/TP53/PIK3R3	3.20702296921297
Genetic Information Processing	Transcription	hsa03040	Spliceosome	54/1435	243/9376	1.45195509097948	HSPA1B/HSPA8/HSPA6/HNRNPC/DDX39B/SRSF2/BCAS2/SNRPB/RBM8A/PRPF38B/HSPA1A/PRPF8/DDX5/RBM25/SRSF7/FUS/HNRNPU/SNRPD2/SF3B3/CASC3/CWC25/SF1/SNIP1/SNW1/CCDC12/TRA2B/PRPF3/RBMX/EIF4A3/HNRNPM/BUD31/PRPF38A/PRPF18/SF3B1/SRSF10/SNRNP70/SNRNP200/SMNDC1/WBP11/SF3B2/SRSF4/SNRPA1/RBM22/ISY1/SF3A1/SLU7/SRSF5/THOC1/TRA2A/THOC2/LSM2/SF3A2/SRSF8/PRPF6	3.0343500562331
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	31/1435	122/9376	1.66022733763637	PIK3R1/PLCG2/SOCS1/ITPR1/MAPK1/MAP2K3/AKT3/STAT3/MAP2K1/STAT1/RAF1/MAPK8/SOS2/KRAS/STAT5B/CREBBP/PIK3CB/IRS2/MAP2K2/EP300/MAPK14/CREB1/ITPR3/SOCS2/PRKACB/ADCY7/PIK3CD/CRK/SOS1/MAP2K4/PIK3R3	3.12020164454437
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	22/1435	78/9376	1.84286607701242	PLCG2/PIP4K2A/ITPKB/SACM1L/INPP5D/INPP5A/TPI1/INPP4A/PI4KA/PIK3CG/IP6K1/PIK3CB/PIP5K1A/ITPK1/ITPKC/PI4K2B/INPP5K/PLCH2/PIK3CD/PIP5K1C/MTMR1/MTMR3	3.17749661231668
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	42/1435	181/9376	1.51612990163051	BCL2/HSPD1/TGFB1/JAK1/NFKB1/HSPA9/PPP3CC/MAPK1/AKT3/KSR1/HLA-DPB1/CYCS/CASP8/LSP1/CASP3/MALT1/STAT1/CALM1/IFNGR1/RAF1/MAPK8/HLA-DRB1/HLA-DQB1/CREBBP/ITGAX/HLA-DRB5/CASP10/IL18/EP300/MAPK14/IFNG/CREB1/IRAK4/SPHK1/IRAK2/HLA-DPA1/RELA/IL10RA/BID/PPP3R1/PLK3/HLA-DQA1	2.98055013739943
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	21/1435	75/9376	1.82946341463415	BCL2/CCND3/CYCS/CASP8/CDKN1A/CASP3/CCND2/SERPINE1/MDM2/GADD45B/SESN1/GADD45A/DDB2/CDK6/THBS1/SESN2/PPM1D/CDKN2A/SIVA1/BID/TP53	3.06575210742078
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	27/1435	105/9376	1.68011946241911	GABARAPL1/UBC/ARIH1/SQSTM1/OPTN/EIF2AK3/HUWE1/RRAS2/BCL2L13/MAPK8/RPS27A/USP15/TBK1/KRAS/MAP1LC3B/USP8/SMURF2/AMBRA1/OPA1/BECN1/FOXO3/TAX1BP1/RELA/ULK1/TP53/SMURF1/CALCOCO2	2.9791375298978
Organismal Systems	Immune system	hsa04611	Platelet activation	31/1435	126/9376	1.60752170787014	FYN/PIK3R1/PLCG2/ITPR1/RASGRP1/MAPK1/STIM1/AKT3/GP6/TLN1/RAP1B/ITGB1/ARHGEF1/PIK3R6/PIK3CG/PIK3R5/PIK3CB/APBB1IP/MAPK14/PPP1R12A/ITPR3/F2R/PRKACB/PPP1CB/ADCY7/PIK3CD/RAP1A/MYLK/GNA13/PIK3R3/ROCK1	2.91843615951203
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	19/1435	67/9376	1.85286806386188	BRAF/ITPR1/RPS6KA3/PPP3CC/MAPK1/RAP1B/MAP2K1/CALM1/RAF1/KRAS/CREBBP/MAP2K2/CAMK4/EP300/ITPR3/PRKACB/PPP1CB/RAP1A/PPP3R1	2.97811681853828
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	34/1435	144/9376	1.5427022841657	FOXO1/NFKB1/LPIN1/TCF7/TRAF3/MAP2K3/AKT3/NFKBIA/CASP8/CASP3/RIPK1/CPT1A/MAPK8/PRKAG2/ADIPOR2/TBK1/LPIN2/TRA2B/FASLG/MAPK14/IRF3/PRKAA1/FOXO3/IRAK4/IKBKB/TAB2/IL17RA/RELA/ACOX1/MAP2K4/TRA2A/MAP2K7/MAP3K14/MAP3K5	2.7897737809607
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	21/1435	78/9376	1.75909943714822	TGFB1/JAK1/NFKB1/ITGA4/MAPK1/HLA-DPB1/NFKBIA/ITGB1/STAT1/IFNGR1/HLA-DRB1/HLA-DQB1/HLA-DRB5/MAPK14/IFNG/PTGS2/IRAK4/TAB2/HLA-DPA1/RELA/HLA-DQA1	2.86170716289774
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	25/1435	98/9376	1.66678518097134	PIK3R1/PLCG2/PTPRC/VAV3/MAPK1/AKT3/INPP5D/PRKCE/DNM2/MAP2K1/PLA2G6/RAF1/ARF6/PIK3CB/RPS6KB1/RAC2/PIP5K1A/ARPC5L/SPHK1/PLPP1/PIK3CD/CRK/PIP5K1C/PAK1/PIK3R3	2.82062781131341
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	11/1435	32/9376	2.24599303135889	GABARAPL1/ATG16L1/ATG4B/PPP2CA/ATG12/BECN1/ATG101/ATG5/ATG13/ATG2A/ATG2B	3.00122239439186
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	28/1435	116/9376	1.5771236333053	CXCR4/PIK3R1/PLCG2/EZR/RHOH/VAV3/PTK2B/ITK/ITGA4/RASSF5/ACTN4/MYL9/MSN/TXK/RAP1B/ITGB1/ACTN1/ITGAL/PIK3CB/RAC2/MAPK14/PTPN11/CD99/PIK3CD/RAP1A/SIPA1/PIK3R3/ROCK1	2.65868172950171
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	17/1435	63/9376	1.7630883247608	KMT2E/EZH2/PRDM2/SETD2/NSD3/KMT2C/EHMT1/NSD2/KMT2A/SMYD3/SMYD2/ASH1L/PHYKPL/SETD1B/DOT1L/DLST/KMT5C	2.5832966031225
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	21/1435	83/9376	1.65312959153688	CCL5/NFKB1/ZBP1/NFKBIA/CASP8/CASP3/RIPK1/G3BP1/CCL4/CGAS/TBK1/CCL4L2/IL18/POLR2K/IRF3/ADAR/POLR3E/IKBKB/POLR3C/RELA/POLR1D	2.54058909279979
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	35/1435	157/9376	1.45657915177878	PIK3R1/TGFB1/NFKB1/BCL2L11/AKT3/CYCS/CASP8/ERN1/EIF2AK3/CASP3/SDHA/MAPK8/PRKAG2/ADIPOR2/DDIT3/PIK3CB/IRS2/FASLG/MAPK14/MLXIP/PRKAA1/IKBKB/NDUFA10/NDUFV1/NDUFS5/UQCRC2/PIK3CD/ITCH/RELA/BID/XBP1/PIK3R3/NDUFA7/MAP3K5/UQCRFS1	2.45243771526728
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	25/1435	104/9376	1.57062449745377	GPCPD1/LPIN1/DGKD/AGPAT4/CHKA/PLA2G6/PLAAT3/LPIN2/SELENOI/SAMD8/PTDSS1/CHPT1/GPD2/DGKA/LPCAT1/GPAT4/SGMS2/CDS2/PLPP1/AGPAT5/LCLAT1/DGKZ/DGKE/MBOAT7/PCYT1A	2.48745000859587
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1435	14/9376	2.80019910403186	ST3GAL1/B3GNT7/B4GALT1/B3GNT2/ST3GAL2/B4GALT4	2.86532725874707
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	72/1435	368/9376	1.27835176488411	TUBA4A/BCL2/RANBP2/NUP98/TNFRSF1B/PPP3CC/MAP2K3/SQSTM1/NXT1/OPTN/CYCS/NUP88/ERN1/RB1CC1/EIF2AK3/CASP3/TUBB4B/POM121/SRSF7/NUP153/FUS/SDHA/SETX/TBK1/MAP1LC3B/DDIT3/KLC1/NUP210/AMBRA1/ATXN2L/UBQLN1/PSMD7/TPR/MAPK14/TARDBP/ANXA11/SEC13/NUP58/HSPA5/BECN1/PSMA7/ITPR3/ATG101/NXF1/MCU/NDUFA10/NDUFV1/ATG13/NDUFS5/KIF5B/ATG2A/UQCRC2/DCTN3/VDAC1/DERL1/ATXN2/BID/ULK1/ATP5MC1/TP53/XBP1/ACTR10/ACTR1B/CHMP2B/NDUFA7/PPP3R1/ATG2B/PSMA6/MAP3K5/UQCRFS1/PSMA5/POM121C	2.315675445536
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	37/1435	170/9376	1.4220618979299	TUBA4A/EZR/RAB8B/MYH9/MYH11/HSPA4/ACTN4/PPP2R2B/TIAM1/MYL9/MSN/PRKCE/PPP2R2A/PATJ/PPP2R2D/ITGB1/LLGL2/RAPGEF6/MAPK8/ACTN1/PRKAG2/PPP2CA/SYMPK/WHAMM/HCLS1/PRKAA1/ARPC5L/PRKACB/RAPGEF2/RAP1A/NF2/DLG3/MAP2K7/ROCK1/MAP3K5/ARHGAP17/PPP2R1B	2.36069083350226
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	11/1435	36/9376	1.99643825009679	GALNT11/B4GALT5/ST3GAL1/GALNT2/GCNT1/GALNT6/GALNT10/GALNT3/GALNT7/ST3GAL2/GALNT15	2.5462567503469
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	15/1435	55/9376	1.78194488438391	B4GALT5/SAMD8/UGCG/CERS5/B4GALT6/CERS6/CERS4/SPTLC1/SPHK1/SGMS2/GALC/SMPD4/PLPP1/SPTLC2/CERK	2.47229462263157
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	36/1435	166/9376	1.41696822131732	ITPR1/MYL9/PPP3CC/ATP1B3/MAPK1/AKT3/ATP2B4/PRKCE/MEF2D/ATP1A1/ATP2A3/MAP2K1/CALM1/PIK3R6/RAF1/ATP2A2/PIK3CG/RGS2/PIK3R5/IRS2/MAP2K2/ATP2B1/PPP1R12A/CREB1/ITPR3/NFATC2/PPP1CB/PPIF/ADCY7/NFATC1/MYLK/VDAC1/GNA13/NFATC3/PPP3R1/ROCK1	2.30409921889452
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	15/1435	56/9376	1.75012444001991	BCL2/CSNK1D/CSNK1G3/CUL3/CUL1/MGRN1/CCND2/SMURF2/CSNK1G2/GRK2/PRKACB/CSNK1E/CSNK1A1/SMURF1/SPOPL	2.39327918481717
Organismal Systems	Digestive system	hsa04978	Mineral absorption	16/1435	61/9376	1.71378305820529	MT1X/MT2A/MT1F/SLC30A1/MT1G/MT1M/MT1E/ATP1B3/ATP2B4/ATP1A1/MT1A/ATP2B1/HMOX2/TRPM7/TF/MT1H	2.37746271239089
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	29/1435	130/9376	1.45753953363709	PIK3R1/TGFB1/NFKB1/MAPK1/ACTA2/GNB5/AKT3/NFKBIA/GNB1/MAP2K1/RAF1/MAPK8/SOS2/KRAS/PIK3CB/MAP2K2/MAPK14/VEGFA/CREB1/PRKACB/ADCY7/PIK3CD/COL4A4/SOS1/GNG4/RELA/MAP2K4/PIK3R3/MAP2K7	2.23304434443926
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	13/1435	47/9376	1.8072206983468	PIK3R1/SOCS1/MAPK1/PRKCE/MAPK8/PKM/PIK3CB/IRS2/SOCS2/IKBKB/PIK3CD/SOCS4/PIK3R3	2.35829246014974
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	16/1435	62/9376	1.68614139597617	KAT2B/ATXN1/CTBP2/SPEN/PSEN1/SNW1/CREBBP/EP300/CIR1/TLE3/MAML1/LFNG/ITCH/NCOR2/HDAC1/MAML3	2.30417436427267
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	22/1435	93/9376	1.54562961297816	FYN/YES1/ACTN4/MYL9/MAPK1/TCF7/SORBS1/SMAD3/RAP1B/ACTN1/IQGAP1/CREBBP/SMURF2/RAC2/PTPN1/EP300/IGF1R/PTPRJ/RAP1A/SMURF1/ROCK1/HEG1	2.24785981004182
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	46/1435	226/9376	1.32988807005643	PIK3R1/PDE4A/VAV3/NFKB1/BRAF/TIAM1/MYL9/ATP1B3/MAPK1/AKT3/ATP2B4/NFKBIA/PDE4B/SLC9A1/RAP1B/ATP1A1/ATP2A3/RRAS2/MAP2K1/CALM1/RAF1/MAPK8/ATP2A2/CREBBP/PIK3CB/MAP2K2/RAC2/CAMK4/ATP2B1/EP300/PPP1R12A/CREB1/F2R/PRKACB/PPP1CB/ADCY7/NFATC1/PIK3CD/RAP1A/PAK1/RELA/ACOX1/PIK3R3/OXTR/ROCK1/GIPR	2.13395016738494
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	33/1435	154/9376	1.40009955201593	BCL2/TPM2/PPP2R2B/PPP2R5C/CREM/ATP1B3/MAPK1/AKT3/ATP2B4/PPP2R2A/SLC9A1/PPP2R2D/ATP1A1/ATP2A3/PPP2R5A/RPS6KA5/CALM1/PIK3R6/ATP2A2/PPP2CA/PIK3CG/PIK3R5/PPP2R3C/ATP2B1/MAPK14/TPM4/CREB1/PPP2R3A/PRKACB/PPP1CB/ADCY7/PPP2R5E/PPP2R1B	2.12808934513163
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	33/1435	154/9376	1.40009955201593	ITPR1/MYL9/PPP3CC/MAPK1/CAMK1D/CDKN1A/MAP2K1/CALM1/PIK3R6/RAF1/PRKAG2/KRAS/PIK3CG/RGS2/PIK3R5/MAP2K2/CAMK4/PPP1R12A/CD38/PTGS2/PRKAA1/ITPR3/NFATC2/PRKACB/PPP1CB/ADCY7/NFATC1/MYLK/NFATC3/OXTR/PPP3R1/ROCK1/CAMK1	2.12808934513163
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	30/1435	139/9376	1.41017221066352	PIK3R1/BCL2/HSP90AA1/FKBP5/HSPA1B/ITPR1/HSPA8/HSPA6/HSP90AB1/MAPK1/AKT3/FKBP4/HSPA1A/MAP2K1/RARA/CALM1/RAF1/NCOA3/SOS2/KRAS/PIK3CB/MAP2K2/TGFA/CREB1/ITPR3/PRKACB/ADCY7/PIK3CD/SOS1/PIK3R3	2.07100979266948
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/1435	54/9376	1.69394760614273	HLA-A/HLA-B/HLA-C/HLA-DPB1/HLA-F/TG/PRF1/HLA-DRB1/HLA-E/HLA-DQB1/HLA-DRB5/FASLG/HLA-DPA1/HLA-DQA1	2.17391722302255
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	62/1435	323/9376	1.25416554298228	CD44/PIK3R1/BCL2/PLCG2/EZR/MCL1/DDIT4/ABCB1/ZEB1/PDCD4/NFKB1/EZH2/SOCS1/BCL2L11/MAPK1/GLS/VIM/STAT3/PRKCE/FOXP1/HDAC4/CDKN1A/SPRY2/CDKN1B/ITGA5/SLC7A1/CASP3/RPS6KA5/MAP2K1/ABCC1/RASSF1/RAF1/CCND2/MDM2/SOS2/TNC/KRAS/CREBBP/PIK3CB/IRS2/CDK6/MAP2K2/ABL1/EP300/PTGS2/VEGFA/DNMT3A/UBE2I/IKBKB/DNMT1/THBS1/HDAC5/PIK3CD/PIM1/MYC/CRK/SOS1/CDKN2A/TP53/PIK3R3/ROCK1/HDAC1	1.97603969702291
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	73/1435	388/9376	1.22929702934732	TUBA4A/PIK3R1/NFKB1/SLC39A10/BRAF/ITPR1/PPP3CC/MAPK1/AKT3/CYCS/CASP8/ERN1/RB1CC1/EIF2AK3/CASP3/PSEN1/ATP2A3/TUBB4B/MAP2K1/CALM1/RAF1/CAPN2/SDHA/MAPK8/ATP2A2/KRAS/AXIN1/DDIT3/KLC1/PIK3CB/IRS2/AMBRA1/MAP2K2/GAPDH/PSMD7/EIF2AK2/SLC39A8/PTGS2/BECN1/PSMA7/ITPR3/ATG101/IKBKB/MCU/NDUFA10/NDUFV1/ATG13/RTN3/NDUFS5/CSNK1E/PPIF/KIF5B/ATG2A/UQCRC2/ADAM10/PIK3CD/VDAC1/APBB1/RELA/BID/ULK1/ATP5MC1/XBP1/CSNK1A1/PIK3R3/MAP2K7/NDUFA7/PPP3R1/ATG2B/PSMA6/MAP3K5/UQCRFS1/PSMA5	1.96090588504549
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	17/1435	70/9376	1.58677949228472	PRKCQ/NFKB1/TNFRSF1B/AKT3/STAT3/NFKBIA/ACSL3/CPT1A/MAPK8/PRKAG2/ADIPOR2/ACSL5/IRS2/PTPN11/PRKAA1/IKBKB/RELA	2.094673862805
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	33/1435	157/9376	1.37334605739142	TGFB1/AREG/SMAD7/CSNK1D/PPP2R2B/CCND3/TCF7/BIRC3/YWHAZ/ID2/PPP2R2A/PATJ/SMAD3/BIRC2/PPP2R2D/LLGL2/TP53BP2/RASSF1/CCND2/SERPINE1/YWHAQ/LATS2/AXIN1/PPP2CA/YWHAG/NKD1/CSNK1E/PPP1CB/BMP8A/MYC/NF2/DLG3/PPP2R1B	2.00536522183713
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	47/1435	238/9376	1.29028782244605	PIK3R1/PLCG2/RPS26/JAK1/NFKB1/RPS27/MAPK1/TRAF3/STAT3/RPS29/NFKBIA/RPS3/RPS4Y1/RPS19/STAT1/RPS15A/CGAS/MAPK8/RPS27A/TBK1/RPL41/RPS21/PIK3CB/EIF2AK2/RPL13/MAPK14/IRF3/IRAK4/OAS2/RSL24D1/ADAR/IRF9/IKBKB/CSF3/RPSA/TAB2/IFNAR2/RPL3/MX1/PIK3CD/C1S/IFIH1/RELA/TYK2/PIK3R3/RPL17/RPL30	1.92826052250561
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	25/1435	115/9376	1.42039084987123	BCL2/PDE4A/RUNX2/BRAF/ITPR1/AKAP13/NR4A2/JUND/GATA3/MAPK1/PDE4B/MEF2D/CDKN1A/OXSR1/STK39/ARHGEF1/MAP2K1/RAF1/WNK1/CREB1/ITPR3/PRKACB/ADCY7/GNA13/MMP24	1.92817844459659
NA	NA	hsa04518	Integrin signaling	32/1435	154/9376	1.35767229286393	PIK3R1/TGFB1/ITGAE/ITGA4/ICAM3/ACTN4/FLNA/CCND3/AKT3/TLN1/ITGA5/ITGB1/CCND2/ACTN1/TNC/ITGAX/ITGAL/PIK3CB/RAC2/PDGFD/ITGAD/LIMS1/VEGFA/IGF1R/PARVG/THBS1/PIK3CD/NCK2/COL4A4/ICAM2/PIK3R3/ARHGEF6	1.90242301361594
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	24/1435	110/9376	1.42555590750713	PIK3R1/HSP90AA1/BRAF/RPS6KA3/HSP90AB1/MAPK1/AKT3/STK10/MAP2K1/RAF1/MAPK8/KRAS/PIK3CB/MAPK14/ANAPC16/ANAPC5/IGF1R/PRKACB/ADCY7/PIK3CD/CPEB2/MAD1L1/PIK3R3/AURKA	1.90845010038071
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	29/1435	138/9376	1.37304448820886	ITPR1/RPS6KA3/PPP2R5C/PPP3CC/MAPK1/YWHAZ/CUL1/PPP2R5A/MAP2K1/CALM1/YWHAQ/PPP2CA/MAPK14/ANAPC16/ANAPC5/YWHAG/ITPR3/IGF1R/SLK/PRKACB/PPP1CB/ADCY7/CPEB2/MAD1L1/PPP3R1/PPP2R5E/AURKA/SKP1/PPP2R1B	1.87665820771439
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	42/1435	212/9376	1.29443166129775	PIK3R1/SIPA1L1/VAV3/SKAP1/BRAF/RASSF5/TIAM1/EVL/MAPK1/MAP2K3/AKT3/TLN1/RAP1B/ITGB1/RALGDS/RAPGEF1/PRKD2/MAP2K1/RAPGEF6/CALM1/RAF1/KRAS/ITGAL/PIK3CB/MAP2K2/RAC2/PDGFD/APBB1IP/MAPK14/PRKD3/RALA/VEGFA/F2R/IGF1R/THBS1/ADCY7/RAPGEF2/PIK3CD/CRK/RAP1A/SIPA1/PIK3R3	1.84324850510502
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	18/1435	78/9376	1.50779951755562	PIK3R1/SEPTIN6/ARHGAP10/DNM2/ITGA5/ITGB1/PIK3CB/SEPTIN11/SEPTIN1/HCLS1/ARPC5L/CD2AP/PIK3CD/CBL/CRK/SEPTIN9/PIK3R3/ELMO2	1.91433881464094
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	9/1435	33/9376	1.78194488438391	STX11/STX5/VAMP2/STX16/STX18/STX4/STX6/STX17/VAMP1	1.91277518539734
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	32/1435	158/9376	1.32330084241168	PIK3R1/SLC7A5/DDIT4/LPIN1/BRAF/RPS6KA3/MAPK1/AKT3/MAP2K1/RAF1/SOS2/LPIN2/KRAS/CAB39/PIK3CB/RPS6KB1/MAP2K2/RICTOR/SLC3A2/SEC13/PRKAA1/IGF1R/IKBKB/FNIP1/EIF4B/SESN2/PIK3CD/STRADA/SOS1/ULK1/PRR5L/PIK3R3	1.74217195594623
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	9/1435	34/9376	1.72953474072556	POLR2A/CRCP/POLR2B/POLR2K/POLR2J3/POLR3E/POLR3C/POLR2D/POLR1D	1.81150482764065
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	20/1435	93/9376	1.40511782998014	PTK2B/ITPR1/MAPK1/MAP2K3/MAP2K1/CALM1/RAF1/MAPK8/SOS2/KRAS/MAP2K2/MAPK14/MAP3K2/ITPR3/PRKACB/ADCY7/SOS1/MAP3K4/MAP2K4/MAP2K7	1.66898582240289
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/1435	50/9376	1.56811149825784	CXCR4/TGFB1/ITGA4/HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DRB5/HLA-DPA1/IL15/CCL28/HLA-DQA1/MAP3K14	1.71216204950195
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	21/1435	99/9376	1.3859571322986	PRKCH/PIK3R1/PLCG2/PRKCQ/ITPR1/MAP2K3/PRKCE/PTGER4/PLA2G6/CALM1/MAPK8/PIK3CB/MAPK14/ITPR3/TRPV2/PRKACB/PPP1CB/ADCY7/PIK3CD/PIK3R3/NTRK1	1.64106914711772
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	43/1435	227/9376	1.23767978019617	PIK3R1/NFKB1/BRAF/NFE2L2/MAPK1/AKT3/NFKBIA/PRKD2/MAP2K1/RAF1/SDHA/MAPK8/SOS2/KRAS/PIK3CB/MAP2K2/ABL1/PTPN1/MAPK14/PRKD3/PTPN11/VEGFA/FOXO3/IKBKB/PTPRJ/NDUFA10/NDUFV1/NDUFS5/PPIF/UQCRC2/PIK3CD/VDAC1/SOS1/SOD2/RELA/ATP5MC1/MAP2K4/PIK3R3/MAP2K7/NDUFA7/MAP3K14/MAP3K5/UQCRFS1	1.54096346719769
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	85/1435	480/9376	1.15702671312427	TUBA4A/BCL2/UBC/NFKB1/BRAF/ITPR1/TNFRSF1B/PPP3CC/MAPK1/MAP2K3/ATXN1/SQSTM1/OPTN/UBE2G1/CYCS/CASP8/ERN1/HIP1/RB1CC1/EIF2AK3/CASP3/PSEN1/ATP2A3/TUBB4B/MAP2K1/FUS/CALM1/RAF1/CAPN2/SDHA/MAPK8/RPS27A/ATP2A2/TBK1/KRAS/MAP1LC3B/AXIN1/DDIT3/KLC1/AMBRA1/ATXN2L/MAP2K2/PSMD7/FASLG/MAPK14/PTGS2/TARDBP/HSPA5/BECN1/PSMA7/ITPR3/ATG101/MCU/NDUFA10/NDUFV1/ATG13/NDUFS5/CSNK1E/PPIF/UBE2L6/KIF5B/ATG2A/UQCRC2/DCTN3/VDAC1/DERL1/RELA/ATXN2/BID/ULK1/ATP5MC1/XBP1/ACTR10/ACTR1B/CHMP2B/CSNK1A1/MAP2K7/NDUFA7/PPP3R1/ATG2B/PSMA6/MAP3K5/UBE2J1/UQCRFS1/PSMA5	1.50131133113357
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	56/1435	308/9376	1.18796325625594	TUBA4A/ITPR1/RCOR1/AP2B1/POLR2A/CYCS/CASP8/ERN1/HIP1/RB1CC1/CASP3/TUBB4B/TAF4B/SDHA/MAPK8/TGM2/POLR2B/KLC1/CREBBP/AMBRA1/PSMD7/EP300/POLR2K/TBPL1/POLR2J3/BECN1/NRF1/PSMA7/CREB1/ATG101/SIN3A/NDUFA10/NDUFV1/ATG13/NDUFS5/PPIF/KIF5B/ATG2A/UQCRC2/DCTN3/VDAC1/SOD2/POLR2D/ULK1/ATP5MC1/TP53/ACTR10/ACTR1B/MAP2K7/NDUFA7/ATG2B/PSMA6/HDAC1/MAP3K5/UQCRFS1/PSMA5	1.42582607717798
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1435	63/9376	1.45195509097948	CCNH/POLR2A/MNAT1/ERCC1/ERCC5/POLR2B/DDB2/XPC/POLR2K/POLR2J3/RPA1/POLR2D/GTF2H1/LIG1	1.53001168201229
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	35/1435	184/9376	1.24284199363733	FYN/CXCR4/PIK3R1/PLCG2/SEMA4D/MYL9/PPP3CC/MAPK1/ITGB1/SSH1/EPHA4/SSH2/RAF1/PLXNA4/KRAS/PIK3CB/RAC2/ABL1/NCK1/PLXNC1/SRGAP3/PTPN11/PAK2/SEMA4A/RASA1/NFATC2/ABLIM1/PIK3CD/NCK2/PAK1/RGS3/NFATC3/PIK3R3/PPP3R1/ROCK1	1.4141702085525
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	23/1435	115/9376	1.30675958188153	FYN/PIK3R1/BCL2/KCNQ5/ITPR1/MAPK1/GNB5/AKT3/GNB1/MAP2K1/PIK3R6/KRAS/PIK3CG/PIK3R5/PIK3CB/CAMK4/CREB1/ITPR3/PRKACB/ADCY7/PIK3CD/GNG4/PIK3R3	1.40699354811983
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	29/1435	150/9376	1.26320092915215	PIK3R1/BCL2/TGFB1/ABCB1/BRAF/MAPK1/TCF7/AKT3/SMAD3/CDKN1A/CDKN1B/MAP2K1/RAF1/SOS2/KRAS/GADD45B/AXIN1/GADD45A/PIK3CB/DDB2/RPS6KB1/MAP2K2/MLH1/PIK3CD/MYC/SOS1/TP53/CSNK1A1/PIK3R3	1.38133912589064
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	20/1435	98/9376	1.33342814477707	NR4A1/LDLR/ITPR1/NR4A2/ATP1B3/CAMK1D/ATP2B4/PRKCE/ATP1A1/PRKD2/CALM1/CAMK4/ATP2B1/PRKD3/CREB1/ITPR3/ATF1/PRKACB/ADCY7/CAMK1	1.41046430705434
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	26/1435	133/9376	1.27728380183909	ITPR1/PPP2R2B/PPP2R5C/PPP3CC/GNB5/AKT3/PPP2R2A/PPP2R2D/GNB1/PPP2R5A/CALM1/MAPK8/PPP2CA/PPP2R3C/MAPK14/CREB1/ITPR3/PPP2R3A/PRKACB/PPP1CB/KIF5B/MAOB/GNG4/GNAL/PPP2R5E/PPP2R1B	1.36904535068745
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	14/1435	65/9376	1.40727954971857	LPIN1/DGKD/AGPAT4/LPIN2/DGKA/PNPLA2/AGK/ABHD16A/GPAT4/PLPP1/AGPAT5/LCLAT1/DGKZ/DGKE	1.40063543543524
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	26/1435	134/9376	1.26775183316865	PRKCH/ACTG2/PRKCQ/MYH9/BRAF/MYH11/ITPR1/MYL9/MAPK1/ACTA2/PRKCE/ARHGEF1/MAP2K1/PLA2G6/CALM1/RAF1/MAP2K2/PPP1R12A/ITPR3/RAMP1/PRKACB/PPP1CB/ADCY7/MYLK/GNA13/ROCK1	1.32701508790245
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	11/1435	49/9376	1.46677095925478	GALNT11/OGT/GALNT2/B4GALT1/GALNT6/GALNT10/GXYLT1/GALNT3/GALNT7/LFNG/GALNT15	1.39253099466951
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	20/1435	100/9376	1.30675958188153	CXCR4/CCL5/XCL1/TNFSF14/XCL2/IL2RG/CCL21/IL2RB/TNFRSF1B/IL18R1/CCL14/CCL4/IL18RAP/CCL4L2/IL2RA/IL18/CXCR3/IL10RA/CCL28/CCL18	1.31096699466895
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	20/1435	100/9376	1.30675958188153	CD44/CD7/ITGA4/CD2/HLA-DPB1/IL4R/CD55/ITGA5/CD37/HLA-DRB1/HLA-DQB1/HLA-DRB5/IL2RA/FLT3LG/CD38/CSF3/CD3E/HLA-DPA1/HLA-DQA1/IL9R	1.31096699466895
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	27/1435	142/9376	1.24234185601413	PIK3R1/BCL2/HSP90AA1/NFKB1/NFE2L2/HSP90AB1/AKT3/SQSTM1/CALM1/MAPK8/TXN/PIK3CB/RAC2/MAPK14/IFNG/GSTP1/SDC4/VEGFA/PRKAA1/IKBKB/PIK3CD/RELA/MAP2K4/TP53/PIK3R3/MAP2K7/MAP3K5	1.23694861167999
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	33/1435	178/9376	1.21132208432839	TBL1X/PPP3CC/CCND3/TCF7/CACYBP/CCDC88C/CTBP2/FOSL1/SMAD3/CUL1/SENP2/PSEN1/CCND2/MAPK8/AXIN1/CREBBP/RAC2/EP300/TLE3/CHD8/PPARD/NKD1/NFATC2/PRKACB/CSNK1E/TBL1XR1/NFATC1/MYC/NFATC3/TP53/CSNK1A1/PPP3R1/SKP1	1.20999109709024
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	12/1435	59/9376	1.32890804937105	PIK3R1/AKT3/PLAAT3/PIK3CB/IRS2/PNPLA2/PTGS2/PRKACB/ADCY7/PIK3CD/PIK3R3/FABP4	1.07729948171518
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	27/1435	148/9376	1.19197664563518	PIK3R1/BRAF/MAPK1/TCF7/AKT3/NFKB2/CDKN1A/MAP2K1/RAF1/NCOA3/SOS2/KRAS/GADD45B/AXIN1/GADD45A/PIK3CB/DDB2/RPS6KB1/CDK6/MAP2K2/IGF1R/PIK3CD/MYC/SOS1/TP53/CSNK1A1/PIK3R3	1.00068975740757
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1435	15/9376	1.74234610917538	ST3GAL1/ST6GALNAC6/ST3GAL5/ST3GAL2	1.22310835901939
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	14/1435	71/9376	1.28835451734799	CCL5/PLCG2/NFKB1/NFKBIA/CASP3/MAPK8/MAPK14/PTPN11/IKBKB/ADAM10/PAK1/RELA/MAP2K4/MAP3K14	1.03674448975118
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	20/1435	107/9376	1.22127063727246	FOXO1/ITPR1/PPP3CC/AKT3/LDHA/PFKP/CPT1A/CALM1/SIK2/PRKAG2/PPP4R3A/PKM/CREBBP/EP300/PRKAA1/CREB1/ITPR3/PRKACB/PDHA1/PPP3R1	0.978527927641125
Organismal Systems	Nervous system	hsa04730	Long-term depression	12/1435	60/9376	1.30675958188153	BRAF/ITPR1/MAPK1/MAP2K1/RAF1/KRAS/PPP2CA/MAP2K2/ITPR3/IGF1R/GNA13/PPP2R1B	1.01328826514603
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	26/1435	144/9376	1.17971351142083	PIK3R1/JARID2/SKIL/JAK1/MAPK1/TCF7/AKT3/STAT3/ID2/PCGF5/SMAD3/MAP2K1/RAF1/KRAS/KAT6A/AXIN1/PIK3CB/MAP2K2/MAPK14/IGF1R/LIF/PIK3CD/MYC/SMARCAD1/PIK3R3/ACVR1B	0.923821507434696
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1435	38/9376	1.37553640198056	PIK3R1/ATP1B3/MAPK1/ATP1A1/KRAS/PIK3CB/PIK3CD/PIK3R3	0.986031740600697
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	8/1435	38/9376	1.37553640198056	PTPRC/IL2RG/LCK/TAP1/ZAP70/CD3E/ADA/TAP2	0.986031740600697
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	9/1435	44/9376	1.33645866328793	POLB/POLG/PARP4/TDP1/APTX/PARP1/PNKP/TDG/LIG1	0.950921527026032
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	28/1435	160/9376	1.14341463414634	HLA-A/PTPRC/HLA-B/NCAM1/HLA-C/ITGA4/ICAM3/CD58/CD2/HLA-DPB1/HLA-F/ITGB1/TIGIT/HLA-DRB1/HLA-E/HLA-DQB1/ITGAL/HLA-DRB5/SDC4/CD99/SPN/SELPLG/VSIR/GLG1/HLA-DPA1/CD6/ICAM2/HLA-DQA1	0.777779009549131
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	9/1435	46/9376	1.27835176488411	PSME4/PSME1/PSMB9/PSME2/PSMD7/IFNG/PSMA7/PSMA6/PSMA5	0.804462981052712
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1435	23/9376	1.42039084987123	ATP1B3/GLS/GLUD1/ATP1A1/SLC4A4	0.858056126019604
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	46/1435	275/9376	1.09292619575546	FYN/CCL5/TUBA4A/PIK3R1/NCAM1/HSPA1B/ITPR1/HSPA8/HSPA6/PPP3CC/MAPK1/STIP1/CYCS/EIF2AK3/CASP3/HSPA1A/TUBB4B/SDHA/MAPK8/DDIT3/KLC1/PIK3CB/RAC2/PSMD7/MAPK14/HSPA5/PSMA7/CREB1/ITPR3/MCU/NDUFA10/NDUFV1/NDUFS5/PRKACB/PPIF/KIF5B/UQCRC2/PIK3CD/VDAC1/ATP5MC1/PIK3R3/NDUFA7/PPP3R1/PSMA6/UQCRFS1/PSMA5	0.664865715493842
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1435	89/9376	1.17461535450025	TUBA4A/CSNK1D/ITPR1/MAPK1/TUBB4B/MAP2K1/RAF1/SOS2/KRAS/MAP2K2/PDGFD/MAP3K2/ITPR3/PRKACB/ADCY7/SOS1	0.703580349241183
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	12/1435	65/9376	1.20623961404449	PIK3R1/ITPR1/MAPK1/AKT3/MAP2K1/RAF1/KRAS/PIK3CB/MAP2K2/ITPR3/PIK3CD/PIK3R3	0.709258571467208
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	14/1435	78/9376	1.17273295809881	IRF1/NFKB1/MAPK1/ITGA5/ITGB1/CASP3/IRF8/CALM1/MAPK8/MAPK14/IRF3/IRAK4/C1S/RELA	0.651181016965197
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1435	30/9376	1.30675958188153	NFKB1/ABCC1/IKBKB/MTR/RELA/FPGS	0.715352117251631
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1435	42/9376	1.24453293512527	ACSL3/MAP1LC3B/ACSL5/SLC39A8/SLC3A2/ATG5/TF/TP53	0.675152839268483
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	39/1435	235/9376	1.08433241900808	RPS6KA3/SMARCA2/MAP2K3/ACSL3/CPT1A/SDHA/PRKAG2/SOS2/KRAS/DPF3/COX20/ACSL5/RPS6KB1/SMARCA4/SMARCC1/MAPK14/PNPLA2/PRKAA1/ARID1A/CREB1/KDM3A/NDUFAF7/SLC25A20/COX19/NDUFA10/NDUFV1/NDUFS5/PRKACB/SLC25A29/BMP8A/UQCRC2/COA1/ADCY7/SOS1/ATP5MC1/NDUFA7/ARID1B/MAP3K5/UQCRFS1	0.556551843059405
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	44/1435	268/9376	1.07271308960424	TUBA4A/UBC/SLC39A10/ITPR1/NFE2L2/UBE2G1/CYCS/ERN1/EIF2AK3/CASP3/TUBB4B/CALM1/SDHA/MAPK8/RPS27A/DDIT3/KLC1/TXN/PSMD7/SLC39A8/HSPA5/PSMA7/ITPR3/MCU/NDUFA10/NDUFV1/NDUFS5/PRKACB/PPIF/UBE2L6/KIF5B/UQCRC2/VDAC1/MAOB/GNAL/ATP5MC1/TP53/XBP1/NDUFA7/PSMA6/MAP3K5/UBE2J1/UQCRFS1/PSMA5	0.513384172227011
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1435	50/9376	1.17608362369338	TGFB1/KLRK1/ITGAL/IL18/IFNG/KLRB1/ACKR1/CSF3/THBS1	0.530676986737836
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/1435	44/9376	1.18796325625594	ARHGDIB/DYNC1H1/RAB11A/VAMP2/ARHGDIA/CREB1/PRKACB/STX4	0.53123407469144
Human Diseases	Immune disease	hsa05310	Asthma	6/1435	32/9376	1.22508710801394	HLA-DPB1/HLA-DRB1/HLA-DQB1/HLA-DRB5/HLA-DPA1/HLA-DQA1	0.542167132767657
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1435	26/9376	1.25649959796301	ABCC1/BTD/SLC19A2/LMBRD1/APOB	0.556726056375638
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/1435	52/9376	1.13084963816671	LDLR/APOA2/APOC3/SOAT1/APOC2/VDAC1/STARD3NL/APOB/VAPA	0.402204621168901
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	4/1435	21/9376	1.24453293512527	CHST11/CHST12/XYLT1/UST	0.476869013048138
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	37/1435	233/9376	1.03755589119349	ACTG2/DES/LMNA/MYH9/DIAPH1/CSRP1/TPM2/ITGA4/SUN2/MYH11/FMNL1/EMD/MYL9/SYNE2/ATP1B3/VIM/SPTAN1/TLN1/ITGA5/ITGB1/ATP1A1/LMNB1/PDLIM1/TTN/LBR/SNTB2/ENO1/TPM4/SDC4/SNTB1/TMOD3/FMNL3/THBS1/PDLIM3/SYNPO2/COL4A4/ZYX	0.246766194405056
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	16/1435	99/9376	1.05596733889417	TGFB1/DES/LMNA/TPM2/ITGA4/EMD/ITGA5/ITGB1/ATP2A3/TTN/PRKAG2/ATP2A2/SNTB2/TPM4/SNTB1/PRKAA1	0.237970140773157
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/1435	67/9376	1.07271308960424	PGK1/LDHA/TPI1/PFKP/GPI/PKM/ENO1/GAPDH/BPGM/GALM/PDHA1	0.253905714440434
NA	NA	hsa03272	Virion - Hepatitis viruses	8/1435	48/9376	1.08896631823461	LDLR/CHMP4A/IST1/TGOLN2/SLC10A1/CHMP4B/CHMP1B/VPS4B	0.26267936568256
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1435	29/9376	1.12651688093236	RASSF1/LATS2/CSNK1E/PAK1/NF2	0.290058331785161
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	34/1435	217/9376	1.02372870469982	PIK3R1/BCL2/HSP90AA1/BCL6/NFKB1/RPS6KA3/HSP90AB1/CCND3/MAPK1/AKT3/STAT3/MAP2K1/RAF1/SOS2/PTGES3/KRAS/STAT5B/KPNA1/PIK3CB/RPS6KB1/MAP2K2/VEGFA/CREB1/KPNA4/PRKACB/KPNA2/ADCY7/XIAP/PIK3CD/MYC/SOS1/RELA/PIK3R3/KPNA5	0.150332839239491
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/1435	23/9376	1.13631267989699	GLS/GLUD1/ASL/GOT1	0.278226631420699
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1435	23/9376	1.13631267989699	IDI1/HMGCS1/MVD/FDPS	0.278226631420699
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/1435	30/9376	1.08896631823461	SDHA/SUCLG2/OGDH/PDHA1/DLST	0.207466197870191
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1435	17/9376	1.15302316048371	TXNRD1/SCLY/MTR	0.268436084394885
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1435	17/9376	1.15302316048371	GLUD1/CA5B/CA13	0.268436084394885
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1435	102/9376	1.02490947598552	ITPR1/SLC12A2/RAB11A/ATP1B3/ATP2B4/SLC9A1/RAP1B/ATP1A1/ATP2A3/SLC4A4/ATP2A2/ATP2B1/CD38/ITPR3/ADCY7/RAP1A	0.107523928229254
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1435	76/9376	1.03165230148542	UBC/SORBS1/APOA2/HMGCS1/ACSL3/CPT1A/APOC3/ACSL5/PPARD/PLIN2/ACOX1/FABP4	0.117772693135443
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	39/1435	254/9376	1.00322093884606	CXCR4/PLCG2/PTK2B/ITPR1/PPP3CC/CAMK1D/STIM1/ITPKB/ATP2B4/ORAI2/ATP2A3/CALM1/STIM2/ATP2A2/CYSLTR2/PDGFD/CAMK4/ITPKC/ATP2B1/CD38/TGFA/VEGFA/ITPR3/F2R/NFATC2/MCU/PRKACB/PPIF/SPHK1/ADCY7/NFATC1/MYLK/VDAC1/GNAL/NFATC3/OXTR/PPP3R1/CAMK1/NTRK1	0.022122198979876
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	8/1435	51/9376	1.02490947598552	PAFAH1B1/PLA2G6/PLAAT3/SELENOI/CHPT1/LPCAT1/PLPP1/PAFAH1B2	0.0758227008193784
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/1435	105/9376	0.995626348100216	TGFB1/DES/LMNA/TPM2/ITGA4/EMD/ITGA5/ITGB1/ATP2A3/TTN/ATP2A2/SNTB2/TPM4/SNTB1/PRKACB/ADCY7	-0.0191579733228207
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1435	12/9376	1.08896631823461	NCAM1/CD46	0.131086971298645
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/1435	19/9376	1.03165230148542	OGDH/PDHA1/DLST	0.0587067137200661
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	8/1435	53/9376	0.986233646703044	RAB11A/AP2B1/ATP1B3/ATP2B4/DNM2/ATP1A1/ATP2B1/PRKACB	-0.042722139563074
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1435	54/9376	0.967970060652987	ERCC1/POLH/FANCA/MLH1/WDR48/RPA1/FANCI/REV3L	-0.100339616683564
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	23/1435	155/9376	0.969531302686299	NR4A1/LDLR/BRAF/ITPR1/MAPK1/TCF7/CDKN1A/RAP1B/CDKN1B/PDE8A/MAP2K1/KMT2A/AXIN1/USP8/CDK6/MAP2K2/RBBP5/CREB1/ITPR3/PRKACB/ADCY7/RAP1A/CDKN2A	-0.16259407482578
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1435	20/9376	0.98006968641115	UAP1/GMDS/UGP2	-0.0379278316003546
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	4/1435	27/9376	0.967970060652987	ELOVL5/ELOVL6/ACOT7/ACOX1	-0.0708482959771777
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	11/1435	75/9376	0.958290360046458	ITPR1/ALB/ATP1B3/TG/ATP1A1/HSPA5/CREB1/ITPR3/PRKACB/ADCY7/TTF2	-0.15416161138793
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/1435	13/9376	1.00519967837041	PRKDC/XRCC5	0.00797470517360158
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	7/1435	48/9376	0.952845528455285	PIK3R1/ATP1B3/AKT3/ATP1A1/PIK3CB/PIK3CD/PIK3R3	-0.139226922280835
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	15/1435	103/9376	0.951523967389466	PIK3R1/TGFB1/NFKB1/ACTN4/CASP3/HSPB1/ACTN1/PIK3CB/IFNG/PRKACB/PIK3CD/COL4A4/RELA/GNAL/PIK3R3	-0.210285603963719
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	10/1435	69/9376	0.946927233247488	PPP3CC/CALM1/CAMK4/CREB1/FOSB/PRKACB/PPP1CB/MAOB/PPP3R1/HDAC1	-0.188089870611773
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	44/1435	298/9376	0.964721838972944	CXCR4/CCL5/XCL1/TGFB1/TNFSF14/XCL2/IL2RG/TNFRSF18/CCL21/IL2RB/TNFRSF1B/IL18R1/CCL14/IL32/IL12RB2/IL4R/IL21R/TNFRSF4/CCL4/IFNGR1/RELL1/TNFRSF9/IL18RAP/CCL4L2/IL1RL1/FASLG/IL2RA/IL18/IFNG/CXCR3/TNFRSF12A/CSF3/LIF/BMP8A/IFNAR2/IL17RA/CLCF1/IL15/IL10RA/IL27RA/CCL28/CCL18/ACVR1B/IL9R	-0.2630831128011
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	30/1435	205/9376	0.956165547718195	PIK3R1/TGFB1/NFKB1/AKT3/GFPT1/SMAD3/ATP2A3/SDHA/MAPK8/ATP2A2/PIK3CB/RAC2/GAPDH/MAPK14/PARP1/NDUFA10/NDUFV1/NDUFS5/PPP1CB/PPIF/UQCRC2/PDHA1/PIK3CD/VDAC1/RELA/ATP5MC1/PIK3R3/NDUFA7/PDK3/UQCRFS1	-0.2697479537343
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1435	35/9376	0.933399701343952	PFKFB3/GMDS/TPI1/PFKP/ENOSF1	-0.167798279505931
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	4/1435	28/9376	0.933399701343952	ELOVL5/ACAA2/ELOVL6/ACOT7	-0.150027140318807
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	6/1435	43/9376	0.911692731545256	ACSL3/CPT1A/ECI2/ACSL5/ACAA2/ACOX1	-0.246714137616446
Organismal Systems	Digestive system	hsa04970	Salivary secretion	13/1435	93/9376	0.913326589487093	ITPR1/SLC12A2/ATP1B3/ATP2B4/SLC9A1/ATP1A1/CALM1/VAMP2/ATP2B1/CD38/ITPR3/PRKACB/ADCY7	-0.35707313433338
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1435	37/9376	0.882945663433468	GLS/GLUD1/GFPT1/ASL/GOT1	-0.30325793467058
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1435	37/9376	0.882945663433468	UAP1/GFPT1/GMDS/UGP2/GPI	-0.30325793467058
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1435	45/9376	0.871173054587689	ABCB1/ABCC1/ABCA5/TAP1/ABCG1/TAP2	-0.368233132435803
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1435	23/9376	0.852234509922739	MLH1/RPA1/LIG1	-0.301602863178206
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1435	38/9376	0.859710251237851	SIRT2/CD38/NADSYN1/NNMT/NNT	-0.368353492313475
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	13/1435	95/9376	0.894098661287365	CCL5/TGFB1/HLA-DPB1/HLA-DRB1/HLA-DQB1/ITGAL/HLA-DRB5/IL18/IFNG/VEGFA/HLA-DPA1/IL15/HLA-DQA1	-0.441001287255291
NA	NA	hsa04981	Folate transport and metabolism	4/1435	31/9376	0.843070697988086	ABCC1/MTR/FPGS/MTHFD1	-0.372022517977963
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1435	16/9376	0.816724738675958	GOT1/MAOB	-0.311888890259063
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1435	16/9376	0.816724738675958	ST3GAL1/ST3GAL2	-0.311888890259063
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	10/1435	75/9376	0.871173054587689	PGK1/MAT2A/TPI1/PFKP/ASL/PKM/ENO1/GAPDH/GOT1/MTR	-0.4761529832688
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1435	54/9376	0.846973803071364	LDHA/MAT2A/AMD1/GOT1/DNMT3A/DNMT1/MTR	-0.47938242330125
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1435	97/9376	0.875663637343295	ITPR1/PER1/MAPK1/GNB5/GNB1/RPS6KA5/CALM1/PER2/CREB1/ITPR3/PRKACB/ADCY7/GNG4	-0.523247821467595
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1435	32/9376	0.816724738675958	PFKP/UGP2/B4GALT1/GALM	-0.441454971882024
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1435	76/9376	0.859710251237851	EZR/ITPR1/ATP1B3/SLC9A1/ATP1A1/CALM1/ITPR3/PRKACB/ADCY7/MYLK	-0.521993686260799
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1435	17/9376	0.768682106989137	MYH9/MYH11	-0.405782165614877
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1435	33/9376	0.791975504170626	OGDH/GOT1/PDHA1/DLST	-0.508864629110947
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/1435	85/9376	0.845550317688051	UPP1/ASMTL/DGUOK/NT5C3A/RRM1/ADK/AK2/HPRT1/CTPS1/ADA/ENTPD4	-0.608049930092209
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/1435	41/9376	0.796804623098496	RBBP8/UIMC1/RPA1/BARD1/BABAM2	-0.554271541296581
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	7/1435	56/9376	0.816724738675958	STT3B/ALG13/MAN2A1/MAGT1/DHRSX/B4GALT1/DPM1	-0.584741470371389
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1435	49/9376	0.800056886866245	NFKB1/CREB1/FOSB/PRKACB/MAOB/RELA	-0.596495940222986
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	3/1435	26/9376	0.753899758777808	PLA2G6/PLAAT3/ACOX1	-0.534154508844421
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	11/1435	86/9376	0.835718337249818	DES/LMNA/ITGA4/EMD/TCF7/ITGA5/ITGB1/ATP2A3/ATP2A2/SNTB2/SNTB1	-0.650585604157002
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1435	18/9376	0.725977545489741	ACSL3/ACSL5	-0.494657815201306
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1435	18/9376	0.725977545489741	MTR/LMBRD1	-0.494657815201306
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/1435	57/9376	0.802396234488661	ELOVL5/ACSL3/CPT1A/ACSL5/ACAA2/ELOVL6/ACOX1	-0.636094995675906
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	8/1435	65/9376	0.804159742696328	NR4A1/LDLR/ITPR1/PDE8A/CREB1/ITPR3/PRKACB/ADCY7	-0.673495156468861
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/1435	116/9376	0.844887660699267	GLUD1/PGK1/TPI1/PFKP/SDHA/SUCLG2/GPI/PKM/ENO1/GAPDH/OGDH/GOT1/PDHA1/ACOX1/DLST	-0.714568454175523
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	15/1435	116/9376	0.844887660699267	SLC38A1/HOMER1/ITPR1/PPP3CC/MAPK1/GLS/GNB5/GNB1/SLC38A2/GRK2/ITPR3/PRKACB/ADCY7/GNG4/PPP3R1	-0.714568454175523
Cellular Processes	Cell motility	hsa04814	Motor proteins	26/1435	194/9376	0.875663637343295	TUBA4A/ACTG2/MYH9/TPM2/MYH11/KIF13B/DYNC1H1/MYL9/BICDL1/KIF21A/ACTA2/KIF2A/TUBB4B/MYO1D/MYO9B/STARD9/DYNLT1/KLC1/KIF21B/TPM4/TUBD1/KIF5B/DCTN3/HOOK3/ACTR10/ACTR1B	-0.743882547721835
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/1435	10/9376	0.653379790940767	SQOR	-0.466176947562667
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1435	19/9376	0.687768200990281	IDS/HGSNAT	-0.579108057820305
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	7/1435	59/9376	0.775196362133113	UPP1/ASMTL/NT5C3A/RRM1/CTPS1/ENTPD4/CDADC1	-0.736317773386183
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1435	36/9376	0.725977545489741	UGP2/GPI/GBE1/GYG1	-0.700225552838425
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1435	28/9376	0.700049776007964	B4GALT1/B3GNT2/B4GALT4	-0.675682770972442
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1435	44/9376	0.742477035159962	STT3B/ALG13/MAN2A1/MAGT1/B4GALT1	-0.727828282312336
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	6/1435	52/9376	0.753899758777808	LDLR/PTGS2/HSD17B7/IGF1R/PRKACB/ADCY7	-0.756461047024344
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	20/1435	155/9376	0.843070697988086	HLA-A/TUBA4A/HLA-B/HLA-C/DYNC1H1/HLA-DPB1/HLA-F/ITGA5/ITGB1/TUBB4B/HLA-DRB1/HLA-E/HLA-DQB1/HLA-DRB5/TAP1/THBS1/HLA-DPA1/STX18/HLA-DQA1/TAP2	-0.837442257900819
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	10/1435	83/9376	0.787204567398514	ACSL3/PHYH/ECI2/PEX14/ACSL5/HACL1/PEX13/SOD2/NUDT19/ACOX1	-0.827746533108082
Human Diseases	Substance dependence	hsa05032	Morphine addiction	11/1435	91/9376	0.789799747291036	PDE7A/PDE4A/GNB5/PDE4B/GNB1/PDE8A/GRK5/GRK2/PRKACB/ADCY7/GNG4	-0.856518931722139
Organismal Systems	Endocrine system	hsa04924	Renin secretion	8/1435	69/9376	0.75754178659799	ITPR1/PPP3CC/PTGER4/CALM1/CREB1/ITPR3/PRKACB/PPP3R1	-0.859271840870949
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	4/1435	38/9376	0.687768200990281	UAP1/GFPT1/UGP2/GPI	-0.819815236618198
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	14/1435	115/9376	0.79541887592789	BRAF/ITPR1/MAPK1/GNB5/CASP3/GNB1/MAP2K1/RAF1/KRAS/PTGS2/ITPR3/PRKACB/MAOB/GNG4	-0.938338486025591
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	12/1435	101/9376	0.776292820919723	MAPK1/TCF7/MAP2K1/CALM1/RAF1/KRAS/CREBBP/MAP2K2/EP300/CREB1/PRKACB/ADCY7	-0.960854525422513
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/1435	63/9376	0.725977545489741	TCF7/CDKN1A/GADD45B/AXIN1/GADD45A/DDB2/TP53	-0.927653133911515
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/1435	39/9376	0.670133118913607	MAT2A/MTHFD2/MTR/MTHFD1	-0.877488288946247
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1435	31/9376	0.632303023491064	PFKP/GPI/RBKS	-0.871676310924731
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1435	23/9376	0.568156339948493	B4GALT1/B3GALNT2	-0.881432357777111
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	2/1435	23/9376	0.568156339948493	PREP/LNPEP	-0.881432357777111
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1435	32/9376	0.612543554006969	LDHA/SUCLG2/ACOX1	-0.933266024206864
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/1435	50/9376	0.653379790940767	ODC1/AMD1/GOT1/MAOB/P4HA1	-1.04463643028099
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/1435	24/9376	0.544483159117305	XYLT1/HS6ST2	-0.949799202043163
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1435	15/9376	0.435586527293844	AK2	-0.929942014752276
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1435	36/9376	0.544483159117305	RPA1/MCM6/LIG1	-1.16400873900776
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/1435	87/9376	0.675910128559414	TPM2/ATP1B3/SLC9A1/ATP1A1/ATP2A3/ATP2A2/TPM4/UQCRC2/UQCRFS1	-1.2909653747783
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1435	27/9376	0.483985030326494	OXCT1/HMGCS1	-1.14139402213676
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1435	37/9376	0.529767398060081	FASLG/IL18/IFNG	-1.21825275219958
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/1435	89/9376	0.660721136906393	CD44/ITGA4/GP6/ITGA5/ITGB1/TNC/SDC4/THBS1/COL4A4	-1.36706157181156
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	9/1435	89/9376	0.660721136906393	SLC38A1/GABARAPL1/GLS/GNB5/GNB1/SLC38A2/PRKACB/ADCY7/GNG4	-1.36706157181156
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1435	28/9376	0.466699850671976	GCH1/FPGS	-1.20133840162608
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1435	90/9376	0.653379790940767	ABCB1/LDLR/ATP1B3/SLC9A1/ATP1A1/SLC4A4/SLC10A1/PRKACB/ADCY7	-1.40454217855088
Organismal Systems	Sensory system	hsa04744	Phototransduction	2/1435	29/9376	0.450606752372942	GNB1/CALM1	-1.25956384417933
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	10/1435	99/9376	0.659979586808855	HLA-DPB1/HLA-DRB1/HLA-DQB1/ITGAL/HLA-DRB5/CFH/SELPLG/HLA-DPA1/C1S/HLA-DQA1	-1.44574866684032
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1435	30/9376	0.435586527293844	PIGG/PIGB	-1.31619156027413
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1435	30/9376	0.435586527293844	PLA2G6/PLAAT3	-1.31619156027413
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	22/1435	195/9376	0.737146430804967	PIK3R1/PLCG2/NFKB1/MAPK1/AKT3/HDAC4/MAP2K1/RAF1/ITGAL/PIK3CB/MAP2K2/RAC2/MAPK14/CLCN3/SELPLG/PPIF/HDAC5/PIK3CD/VDAC1/RELA/PIK3R3/HDAC1	-1.57674034832723
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/1435	31/9376	0.421535348994043	SRP54/HSPA5	-1.3713301038715
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/1435	51/9376	0.512454737992758	PLCG2/SLC12A2/ERO1A/PRKACB	-1.48405364121571
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	13/1435	128/9376	0.663588850174216	PDE7A/PDE4A/PDE4B/PDE8A/DGUOK/RRM1/ADK/AK2/HPRT1/ADCY7/ADA/PDE6D/ENTPD4	-1.62901636186778
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	8/1435	88/9376	0.59398162812797	CD55/CLU/SERPINE1/ITGAX/CFH/CD46/F2R/C1S	-1.62667169134038
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1435	21/9376	0.311133233781317	PANK2	-1.34337411343008
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1435	22/9376	0.296990814063985	MAOB	-1.40329070364306
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	15/1435	149/9376	0.657764890208825	ITPR1/MAPK1/GNB5/GNB1/MAPK8/MAPK14/PTGS2/ITPR3/NDUFA10/NDUFV1/NDUFS5/PRKACB/ADCY7/GNG4/NDUFA7	-1.7900346025027
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1435	191/9376	0.684167320356824	BRAF/MAPK1/GNB5/HDAC4/GNB1/MAP2K1/CALM1/RAF1/SOS2/KRAS/CAMK4/CREB1/FOSB/PRKACB/PPP1CB/HDAC5/MAOB/SOS1/GNG4/HDAC1	-1.87459804199977
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1435	36/9376	0.36298877274487	UGP2/DCXR	-1.62779192517709
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	3/1435	47/9376	0.417050930387723	LDHA/PKM/PDHA1	-1.70308367752893
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/1435	37/9376	0.353178265373387	GOT1/MAOB	-1.67575016096407
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	7/1435	86/9376	0.531820760068066	ATP1B3/ATP1A1/VAMP2/CREB1/ITPR3/PRKACB/ADCY7	-1.85407591185673
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	3/1435	48/9376	0.408362369337979	OXCT1/HMGCS1/ACAA2	-1.74685207413441
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	27/1435	250/9376	0.705650174216028	LITAF/GNPTAB/OSBPL3/IDS/BORCS5/AP2B1/SLC15A4/IGF2R/GGA2/AP1G1/PLEKHM1/CTSW/OSBPL7/ARSG/OSBP/ABCA5/AP5Z1/HGSNAT/CLN8/VPS13A/AP1S3/ARL8B/GALC/VPS26A/OSBPL2/ENTPD4/STX17	-2.00524547940188
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/1435	59/9376	0.44296934979035	ODC1/RRM1/GSTP1/TXNDC12	-1.824488126447
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/1435	41/9376	0.318721849239398	BPGM/MAOB	-1.85837441989049
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	4/1435	63/9376	0.414844311708423	PLA2G6/PLAAT3/PTGES3/PTGS2	-1.98093805502172
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/1435	42/9376	0.311133233781317	MAOB/DLST	-1.90195383232113
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	2/1435	43/9376	0.303897577181752	PLPP1/APOB	-1.94478112553481
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/1435	31/9376	0.210767674497021	ACOX1	-1.87098389681827
NA	NA	hsa04519	Cadherin signaling	45/1435	404/9376	0.72777451961224	DES/VAV3/PTK2B/KRT81/NFKB1/KRT86/ACTN4/EVL/MAPK1/TCF7/MAP2K3/VIM/YWHAZ/CYFIP2/NFKBIA/PSEN1/RRAS2/MYO1D/MAP2K1/RAF1/YWHAQ/MAPK8/ACTN1/TMC8/LATS2/KRAS/AXIN1/CREBBP/MAP2K2/RAC2/EP300/MAPK14/YWHAG/ARPC5L/IGF1R/ERBIN/IKBKB/PPP1CB/ADAM10/CDH13/RELA/NF2/CSNK1A1/TAOK1/ROCK1	-2.37765486519845
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/1435	143/9376	0.548290733656587	ACTN4/HLA-DPB1/SNRPB/ACTN1/HLA-DRB1/HLA-DQB1/HLA-DRB5/IFNG/RO60/HLA-DPA1/C1S/HLA-DQA1	-2.31382011057971
Genetic Information Processing	Translation	hsa03010	Ribosome	21/1435	222/9376	0.618061964403428	RPS26/RPS27/RPS29/RPS3/RPS4Y1/RPS19/RPS15A/MRPL18/RPS27A/RPL41/RPS21/MRPS6/MRPL1/RPL13/MRPL10/RSL24D1/RPSA/RPL3/MRPS31/RPL17/RPL30	-2.44814949348258
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/1435	82/9376	0.398402311549248	UPP1/RRM1/GSTP1/HPRT1/CDADC1	-2.32587163181637
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	7/1435	103/9376	0.444044518115084	ATP1B3/ATP1A1/COL18A1/SLC3A2/SLC38A2/SLC1A5/COL4A4	-2.41169559448858
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	12/1435	154/9376	0.509127109823974	GCH1/DHRS3/MAT2A/RDH13/UGP2/MTHFD2/AK2/CTPS1/NADSYN1/PANK2/FPGS/MTHFD1	-2.61090361669783
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/1435	79/9376	0.33082521060292	AP2B1/DNM2/VAMP2/NAPA	-2.53895902347202
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	14/1435	183/9376	0.499853391976543	NOP58/NXT1/XPO1/MDN1/GTPBP4/RIOK1/XRN1/NXF1/RAN/FCF1/XRN2/NOP56/SBDS/GNL2	-2.90447895004506
NA	NA	hsa04081	Hormone signaling	18/1435	219/9376	0.53702448570474	PIK3R1/GNB5/STAT3/GNB1/ADIPOR2/STAT5B/PIK3CB/IRS2/IGF1R/RAMP1/PRKACB/ADCY7/PIK3CD/GNA13/GNG4/PIK3R3/OXTR/GIPR	-2.946981868584
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/1435	46/9376	0.142039084987123	HMOX2	-2.47958835685965
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	9/1435	138/9376	0.426117254961369	CYCS/SDHA/NDUFA10/NDUFV1/NDUFS5/UQCRC2/ATP5MC1/NDUFA7/UQCRFS1	-2.88700623594106
NA	NA	hsa04382	Cornified envelope formation	17/1435	217/9376	0.511864352349909	KRT81/KRT86/PPP2R2B/PPP2R5C/PPP2R2A/S100A4/PPP2R2D/PPP2R5A/PPP2CA/UGCG/PPP2R3C/PPP2R3A/SPTLC1/SPTLC2/COL4A4/PPP2R5E/PPP2R1B	-3.09257579684943
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2/1435	68/9376	0.192170526747284	DHRS3/RDH13	-2.8419730411468
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/1435	70/9376	0.18667994026879	PTGS2/GSTP1	-2.90337391407558
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	2/1435	73/9376	0.17900816190158	GSTP1/MAOB	-2.993386184448
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1/1435	66/9376	0.0989969380213283	HSD17B7	-3.12246360426327
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1435	86/9376	0.151948788590876	ITPR3/PRKACB	-3.35843879648138
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/1435	79/9376	0.0827063026507299	GSTP1	-3.48036289914227
NA	NA	hsa04082	Neuroactive ligand signaling	7/1435	199/9376	0.229832087265596	GNB5/GNB1/OGFR/PRKACB/ADCY7/GNG4/GNAL	-4.66805091030413
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	16/1435	370/9376	0.28254261229871	GZMA/NR3C1/PTGER4/CYSLTR2/P2RY10/OGFR/P2RY8/PTGDR/PGRMC2/F2R/CHRNE/OXTR/CNR2/GIPR/LTB4R/CHRNA5	-5.98556282217609
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1435	449/9376	0.101863219077625	NCALD/GNB1/CALM1/RGS2/GRK2/PRKACB/GNAL	-8.29061744734768