category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	23/575	66/9376	5.68242424242424	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/STAT4/NFATC1/NFKB1/TLR2/IL1B/JUN/HLA-DMB/HLA-DOA/IL18/IL4R/STAT3/NOD2/TGFB2/IL1A	9.75711529636477
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	27/575	95/9376	4.63436155606407	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/VEGFA/CCL20/TLR2/IL1B/CXCL3/JUN/HLA-DMB/FLT1/HLA-DOA/CXCL2/CXCL12/IL18/FOS/TGFB2/CXCL8/ACP5/IL1A/IL15	9.10009856466825
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	29/575	112/9376	4.22211180124224	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/CIITA/HLA-DPA1/HSPA1B/HLA-DQA2/HSPA6/HSPA1A/HLA-DMA/NFKBIA/PIK3R5/BCL2/NFKB1/TLR2/HLA-DMB/JAK2/HLA-DOA/HSPA1L/AKT3/MAP2K3/ALOX5/STAT3/TGFB2/MAPK8/IL10RA	8.76806768614941
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	28/575	109/9376	4.18871958516155	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HSP90AA1/HLA-DMA/NFKBIA/NFATC1/NFKB1/IL1B/IL6R/JUN/HLA-DMB/JAK2/IL1RAP/AHR/HLA-DOA/FOS/IL2RA/IL4R/STAT3/NFATC3/MAPK8/RUNX1	8.55881317885376
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	25/575	93/9376	4.3833567087424	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/NFKBIA/STAT4/NFATC1/NFKB1/RBPJ/JUN/HLA-DMB/JAK2/HLA-DOA/FOS/IL2RA/IL4R/MAML3/MAML2/NFATC3/MAPK8	8.38105396689683
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	40/575	216/9376	3.01964573268921	HSPA1B/OLR1/HSPA6/HSPA1A/ABCA1/HSP90AA1/NFKBIA/SOD2/BCL2/NFATC1/NFKB1/APOB/ABCG1/HSPD1/TLR2/IL1B/TRAF3/CXCL3/JUN/APOA1/ATF6/PIK3R1/JAK2/CXCL2/HSPA1L/IL18/EIF2AK3/AKT3/NFE2L2/FOS/VAV3/MAP2K3/POU2F1/PPARG/STAT3/NFATC3/TANK/ITPR1/CXCL8/MAPK8	7.67552136772672
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	36/575	181/9376	3.24319961566178	HLA-DRB1/CD74/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/CIITA/HLA-DPA1/HLA-DQA2/ITGAX/FCGR2B/HLA-DMA/RIPK2/BCL2/IRAK2/NFKB1/HSPD1/TLR2/IL1B/HLA-DMB/RAB7A/JAK2/HLA-DOA/MALT1/IL18/AKT3/NOD2/SYK/TGFB2/RAF1/CLEC7A/MAPK8/CREBBP/IL10RA/IL1A	7.78905718962056
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	48/575	300/9376	2.60897391304348	NR4A1/HSPA1B/HSPA6/HSPA1A/VEGFA/EREG/NFATC1/NFKB1/IL1B/JUN/FLT1/INSR/GADD45G/IL1RAP/HSPA1L/DUSP2/DUSP1/DUSP16/TAOK3/AKT3/FOS/PLA2G4A/PLA2G4C/RELB/MAP2K3/MAP3K2/RAPGEF2/PPM1B/RASA2/GNA12/RPS6KA5/MAP4K3/DUSP5/SOS2/BRAF/NFATC3/DUSP10/STK4/RPS6KA2/TGFB2/RAF1/MAP3K14/MAP2K1/MAPK8/MRAS/MAPK8IP3/RASA1/IL1A	7.23962275762192
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	21/575	78/9376	4.39010033444816	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/NFKBIA/NFKB1/TLR2/IL1B/JUN/HLA-DMB/JAK2/HLA-DOA/PTGS2/FOS/TGFB2/IL1A	7.68455339149282
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	29/575	142/9376	3.33011635027557	FOSB/FCGR2B/GAB2/NFKBIA/NFATC1/NFKB1/IL1B/PLCG2/JUN/PIK3R1/AKT3/FOS/FOSL2/FOSL1/LCP2/RELB/MITF/ATP2A2/PPARG/TREM2/SYK/ITPR1/TGFB2/MAP3K14/TEC1/MAP2K1/MAPK8/ACP5/IL1A	7.15122420812718
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	26/575	119/9376	3.56267446108878	TNFAIP3/NFKBIA/NFKB1/CCL20/CREB5/IL1B/TRAF3/CXCL3/JUN/PIK3R1/ADAM17/TRAF1/CXCL2/PTGS2/AKT3/IRF1/FOS/CFLAR/MAP2K3/RPS6KA5/NOD2/RIPK1/MAP3K14/MAP2K1/MAPK8/IL15	7.19093461293708
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	23/575	100/9376	3.7504	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/TFRC/HLA-DPA1/HLA-DQA2/HLA-DMA/IL3RA/IL1B/IL6R/HLA-DMB/CSF2RA/CSF3R/HLA-DOA/CD55/IL2RA/CSF3/IL4R/IL1A/CD38	7.0675524374984
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	20/575	82/9376	3.97709437963945	HLA-DRB1/CD74/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/CIITA/HLA-DPA1/HSPA1B/HLA-DQA2/HSPA6/HSPA1A/HSP90AA1/HLA-DMA/IFI30/HLA-DMB/HLA-DOA/HSPA1L/CTSB	6.92072742903419
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	34/575	205/9376	2.70442417815483	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/TNFAIP3/HLA-DQA2/HLA-DMA/NFKBIA/BCL2/NFKB1/RBPJ/TLR2/TRAF3/PLCG2/JUN/HLA-DMB/NCOR2/PIK3R1/GADD45G/HLA-DOA/AKT3/RELB/MAP2K3/CD58/HES1/STAT3/SYK/ENTPD1/RIPK1/MAP3K14/MAPK8	6.30666583567636
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	15/575	50/9376	4.89182608695652	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/CXCR4/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DOA/CXCL12/MAP3K14/IL15	7.0525191076693
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	14/575	44/9376	5.18830039525692	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/HSPD1/IL1B/HLA-DMB/HLA-DOA/IL1A	7.11754703901359
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	31/575	193/9376	2.61911241270556	CXCR4/CCL21/ELMO1/FOXO3/NFKBIA/PIK3R5/NFKB1/CCL20/GNAQ/CXCL3/PLCG2/PTK2B/TIAM1/PIK3R1/CCL14/JAK2/CXCL2/CXCL12/AKT3/PREX1/VAV3/DOCK2/STAT3/SOS2/BRAF/FGR/RAF1/CCL18/CXCL8/MAP2K1/GRK3	5.80920783794918
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	15/575	56/9376	4.36770186335404	HSPA1B/HSPA6/HSPA1A/NFKBIA/NFKB1/CLK1/HSPD1/TLR2/IL1B/CXCL3/CXCL2/HSPA1L/IL18/NAIP/CXCL8	6.46060582423655
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	21/575	105/9376	3.26121739130435	TNFAIP3/CCL21/NFKBIA/BCL2/NFKB1/IL1B/TRAF3/CXCL3/PLCG2/GADD45G/TRAF1/CXCL2/CXCL12/MALT1/PTGS2/CFLAR/RELB/SYK/RIPK1/MAP3K14/CXCL8	5.9556233786352
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	21/575	105/9376	3.26121739130435	NFKBIA/NFATC1/NFKB1/IL1B/PLCG2/JUN/PIK3R1/MALT1/PTGS2/AKT3/IRF1/RELB/NFATC3/SYK/ITPR1/RAF1/CBLB/MAP3K14/CLEC7A/MAPK8/MRAS	5.9556233786352
Human Diseases	Immune disease	hsa05310	Asthma	11/575	32/9376	5.60521739130435	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DOA	6.66979153793677
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	13/575	45/9376	4.71064734299517	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/IL1B/HLA-DMB/HLA-DOA/IL1A	6.37742549367385
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	28/575	173/9376	2.63913546117115	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/CIITA/HLA-DPA1/DNAJB1/HLA-DQA2/HLA-DMA/NFKBIA/NUP98/NFKB1/IL1B/TRAF3/NXF1/HLA-DMB/PIK3R1/JAK2/HLA-DOA/IL18/AKT3/RAF1/CXCL8/MAP2K1/CREBBP/IL1A	5.56194559648561
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	33/575	224/9376	2.40223602484472	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/ZFP36/HLA-DMA/NFKBIA/NFATC1/NFKB1/CREB5/ETS2/JUN/HLA-DMB/PIK3R1/HLA-DOA/AKT3/FOS/FOSL1/RELB/IL2RA/MAD1L1/NFATC3/TGFB2/MAP3K14/MAP2K1/MAPK8/EGR1/CREBBP/IL15	5.42926042422225
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	20/575	101/9376	3.22892811020232	FOXO1/VEGFA/BCL2/NFATC1/NFKB1/SERPINE1/IL1B/PLCG2/JUN/PIK3R1/THBD/JAK2/AKT3/PRKCE/STAT3/TGFB2/CXCL8/MAPK8/EGR1/IL1A	5.75643147517979
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	16/575	69/9376	3.78112161310649	GAB2/PLCG2/PIK3R1/AKT3/PLA2G4A/LCP2/PLA2G4C/VAV3/MAP2K3/ALOX5/SOS2/SYK/INPP5D/RAF1/MAP2K1/MAPK8	5.92643081199331
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	29/575	187/9376	2.52875145315043	NAMPT/TNFAIP3/HSP90AA1/NFKBIA/RIPK2/BCL2/NFKB1/IL1B/TRAF3/CXCL3/JUN/NLRP1/GABARAPL1/CXCL2/IL18/P2RX7/NAIP/TXNIP/ERBIN/CTSB/NOD2/TANK/ITPR1/MCU/RIPK1/CXCL8/MAPK8/NEK7/GBP2	5.39730686184168
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	19/575	94/9376	3.2959111933395	FOSB/TNFAIP3/HSP90AA1/NFKBIA/NFKB1/CCL20/IL1B/TRAF3/CXCL3/JUN/CXCL2/PTGS2/MAPK6/FOS/FOSL1/CSF3/CXCL8/MAPK8/USP25	5.71810044793369
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	15/575	62/9376	3.94502103786816	FOXO1/HSPA1B/HSPA6/HSPA1A/PRKAG2/FOXO3/CRYAB/SOD2/IRS2/PIK3R1/INSR/HSPA1L/AKT3/SIRT1/RPTOR	5.94661304917641
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	28/575	180/9376	2.53650241545894	HLA-DRB1/CD74/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/PILRA/NFKBIA/BCL2/NFKB1/TLR2/IL1B/TRAF3/NXF1/HLA-DMB/PIK3R1/JAK2/HLA-DOA/ZC3HAV1/CGAS/AKT3/SRSF7/POU2F1/SYK	5.32014621912873
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	23/575	133/9376	2.81984962406015	FOXO1/PRKAG2/FOXO3/SOD2/IRS2/SGK1/PIK3R1/INSR/GADD45G/GABARAPL1/BCL6/AKT3/STAT3/SOS2/SIRT1/BRAF/STK4/TGFB2/RAF1/MAP2K1/MAPK8/HOMER1/CREBBP	5.40266945338291
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	18/575	91/9376	3.22537983755375	FCGR2B/NFKBIA/NFATC1/NFKB1/PLCG2/JUN/PIK3R1/MALT1/AKT3/FOS/VAV3/CD72/SOS2/NFATC3/SYK/INPP5D/RAF1/MAP2K1	5.45239663498237
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	21/575	120/9376	2.8535652173913	RAPGEF1/IRAK3/FOXO3/NFKBIA/RIPK2/BCL2/IRAK2/NFKB1/PLCG2/JUN/PIK3R1/AKT3/SH2B3/RPS6KA5/GAB1/SOS2/BRAF/RPS6KA2/RAF1/MAP2K1/MAPK8	5.22324468863882
Human Diseases	Immune disease	hsa05330	Allograft rejection	11/575	39/9376	4.59915273132664	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DOA	5.75681735121094
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	25/575	163/9376	2.50093358228861	NFKBIA/STAT4/BCL2/NFATC1/NFKB1/CREB5/TLR2/TRAF3/JUN/PTK2B/PIK3R1/JAK2/AKT3/FOS/MAP2K3/STAT3/SOS2/BRAF/NFATC3/TGFB2/RAF1/CXCL8/MAP2K1/MAPK8/CREBBP	4.9409253386633
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/575	21/9376	6.21184265010352	CHST11/XYLT1/DSE/CSGALNACT1/CHSY1/CHST15/UST/CSGALNACT2	6.11128583713772
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	28/575	196/9376	2.32944099378882	ZFP36/VEGFA/NFKBIA/PIK3R5/NFATC1/NFKB1/TRAF3/CXCL3/PLCG2/JUN/CTNNB1/PIK3R1/JAK2/CXCL2/PTGS2/AKT3/FOS/PREX1/TCF7L2/STAT3/NFATC3/SYK/ITPR1/RAF1/CXCL8/MAP2K1/MAPK8/CREBBP	4.80761090269346
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	24/575	157/9376	2.49265023539186	MERTK/PPARD/THBS1/ABCA1/ELMO1/NFATC1/SGK1/RAB7A/ADAM17/GPR132/JAK2/PTGS2/DUSP2/DUSP16/ALOX5/ATP2A2/PPARG/DUSP5/SIRT1/NFATC3/AXL/ATP11B/MAP2K1/PTGER4	4.82080453136034
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	23/575	149/9376	2.51704697986577	GAB2/CYTH1/PIK3R5/PLCG2/GNA13/PTK2B/DGKD/PIK3R1/INSR/AGPAT4/AKT3/PLA2G4A/PLA2G4C/RALGDS/GNA12/GAB1/SOS2/SYK/RAF1/CXCL8/MAP2K1/MRAS/DNM2	4.77106632736459
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/575	87/9376	2.99882058970515	EREG/BCL2/JUN/CTNNB1/PIK3R1/GADD45G/AKT3/FOS/RALGDS/TCF7L2/SOS2/BRAF/TGFB2/RAF1/MAP2K1/MAPK8	4.78743079826911
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	24/575	166/9376	2.35750654793085	KCNMA1/SLC8A1/IRS2/PIK3R5/NFATC1/CREB5/GNAQ/GNA13/ATP1B3/INSR/AKT3/PRKCE/ATP2A2/PDE2A/GNA12/MEF2D/NFATC3/MYL9/ITPR1/RAF1/MAP2K1/PDE3B/KCNMB1/ADORA3	4.51044832984031
Human Diseases	Infectious disease: viral	hsa05162	Measles	21/575	136/9376	2.51785166240409	HSPA1B/TNFAIP3/HSPA6/HSPA1A/FCGR2B/NFKBIA/BCL2/NFKB1/TLR2/IL1B/TRAF3/JUN/PIK3R1/HSPA1L/AKT3/FOS/IL2RA/STAT3/CBLB/MAPK8/IL1A	4.55739161804945
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	21/575	137/9376	2.49947318311647	MCL1/IL3RA/NFKBIA/BCL2/NFKB1/JUN/PIK3R1/GADD45G/TRAF1/EIF2AK3/AKT3/CTSH/FOS/CFLAR/CTSB/ITPR1/RIPK1/RAF1/MAP3K14/MAP2K1/MAPK8	4.51897619145808
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	15/575	80/9376	3.05739130434783	FOXO3/VEGFA/BCL2/IL6R/PLCG2/PIK3R1/JAK2/AKT3/STAT3/GAB1/SOS2/BRAF/AXL/RAF1/MAP2K1	4.72353770018071
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/575	139/9376	2.46350954019393	HSPA1B/FKBP5/HSPA6/HSPA1A/HSP90AA1/BCL2/CREB5/GNAQ/JUN/PIK3R1/ESR1/HSPA1L/AKT3/NCOA2/FOS/HBEGF/SOS2/NCOA1/ITPR1/RAF1/MAP2K1	4.4431506239282
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	31/575	248/9376	2.03826086956522	HSP90AA1/ELMO1/RHOB/NFKBIA/RIPK2/CYTH1/BCL2/SNX9/NFKB1/TLR2/IL1B/JUN/CTNNB1/RAB7A/PTPRC/IL18/AKT3/FOS/MAP2K3/TCF7L2/NAIP/MYL9/GCC2/ABI1/RIPK1/RAF1/CXCL8/MAP2K1/MAPK8/DNM2/DYNC1H1	4.23543539068656
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	29/575	227/9376	2.08315648343229	AKAP13/CXCR4/VEGFA/NFKBIA/NFATC1/NFKB1/CREB5/IL1B/IL6R/GNAQ/GNA13/PTK2B/CTNNB1/PIK3R1/CXCL12/PTGS2/CGAS/AKT3/GNA12/STAT3/SOS2/NFATC3/ITPR1/RIPK1/RAF1/CXCL8/MAP2K1/IL10RA/PTGER4	4.22251176650726
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	19/575	122/9376	2.53947255880257	NFKBIA/NFATC1/NFKB1/JUN/PIK3R1/PTPRC/MALT1/AKT3/FOS/LCP2/VAV3/SOS2/NFATC3/RAF1/CBLB/MAP3K14/TEC1/MAP2K1/MAPK8	4.3746233809121
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	21/575	144/9376	2.37797101449275	FOXO1/PRKAG2/FOXO3/NFKBIA/NFKB1/IL1B/TRA2B/TRAF3/CXCL3/CTNNB1/C5AR1/CXCL2/AKT3/MAP2K3/TCF7L2/ADIPOR2/SIRT1/RIPK1/MAP3K14/CXCL8/MAPK8	4.25918967026512
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	15/575	86/9376	2.84408493427705	EREG/PLCG2/JUN/ABL2/PIK3R1/AKT3/CBL/HBEGF/GAB1/SOS2/BRAF/RAF1/CBLB/MAP2K1/MAPK8	4.39112538745896
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/575	115/9376	2.55225708884688	AKAP13/PDE4B/BCL2/SGK1/CREB5/GNAQ/NR4A2/GNA13/FOS/HBEGF/GNA12/MEF2D/BRAF/ITPR1/OXSR1/RAF1/MAP2K1/EGR1	4.28092067011283
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/575	77/9376	2.96474308300395	GAB2/NFKBIA/NFKB1/PIK3R1/GADD45G/CTBP2/AKT3/CBL/SOS2/BRAF/TGFB2/RAF1/MAP2K1/RUNX1	4.42472778267969
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	23/575	169/9376	2.21917159763314	IRS2/BCL2/RAB7A/PIK3R1/C9orf72/GABARAPL1/ATG7/ATG16L2/EIF2AK3/DAPK1/AKT3/VMP1/CFLAR/EPG5/RUBCN/CTSB/TANK/ITPR1/RAF1/RPTOR/MAP2K1/MAPK8/MRAS	4.08792262847088
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	20/575	138/9376	2.36320100819156	FOXO1/RAPGEF1/PRKAG2/IRS2/PIK3R1/INSR/SORBS1/AKT3/CBL/PTPN1/SOS2/BRAF/INPP5A/RAF1/RPTOR/CBLB/MAP2K1/MAPK8/PDE3B/PHKA2	4.12348114366073
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	20/575	138/9376	2.36320100819156	ELMO1/NFKBIA/NFATC1/NFKB1/IL1B/GNAQ/JUN/PTK2B/PIK3R1/IL18/AKT3/FOS/LCP2/VAV3/MAP2K3/NFATC3/RPS6KA2/CXCL8/MAP2K1/MAPK8	4.12348114366073
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	13/575	70/9376	3.02827329192547	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/ABL2/HLA-DOA/CD55	4.35358991005788
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	26/575	204/9376	2.07822676896846	TIMP3/THBS1/VEGFA/TLR2/PLCG2/SDC2/CTNNB1/TIAM1/PIK3R1/PLAUR/ESR1/AKT3/CBL/HBEGF/WNT5B/VAV3/EZR/STAT3/GAB1/SOS2/BRAF/ITPR1/TGFB2/RAF1/MAP2K1/MRAS	3.97966687781738
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/575	71/9376	2.98562155541947	FOXO3/NFKB1/PIK3R1/ESR1/JAK2/AKT3/IRF1/FOS/STAT3/SOS2/RAF1/MAP2K1/MAPK8	4.29260586339266
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/575	90/9376	2.71768115942029	FOXO1/PRKAG2/FOXO3/SOD2/IRS2/NFKB1/CREB5/PIK3R1/INSR/AKT3/SESN1/ADIPOR2/PPARG/SIRT1/RPTOR	4.18507280152447
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	17/575	110/9376	2.52003162055336	TFRC/TF/PFKFB3/VEGFA/BCL2/NFKB1/SERPINE1/IL6R/PLCG2/FLT1/PIK3R1/INSR/AKT3/STAT3/ALDOB/MAP2K1/CREBBP	4.09879659895242
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	11/575	54/9376	3.32161030595813	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DOA	4.37305765976639
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	21/575	155/9376	2.20921178120617	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/TFRC/HLA-DPA1/MSR1/HLA-DQA2/THBS1/OLR1/FCGR2B/HLA-DMA/TLR2/HLA-DMB/RAB7A/HLA-DOA/PIKFYVE/CLEC7A/DYNC1H1	3.88000922291573
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	21/575	157/9376	2.18106895596788	FOXO1/FOXO3/NFATC1/NFKB1/SERPINE1/PIK3R1/GADD45G/ZFP36L2/AKT3/MAP2K3/HIPK3/SIRT1/NFATC3/ITPR1/MCU/TGFB2/RAF1/CXCL8/MAP2K1/MRAS/IL1A	3.81449212935288
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	28/575	238/9376	1.9183631713555	GAB2/REL/VEGFA/NFKB1/ETS2/PLCG2/ABL2/TIAM1/FLT1/PIK3R1/INSR/RASA3/AKT3/PLA2G4A/PLA2G4C/RALGDS/RASA2/GAB1/SOS2/RGL1/STK4/RALGAPA1/RAF1/RASAL2/MAP2K1/MAPK8/MRAS/RASA1	3.66801337690534
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/575	41/9376	3.5793849416755	THBS1/VEGFA/DAPK1/HBEGF/RPS6KA5/BRAF/RAF1/CXCL8/MAP2K1	4.23062447340635
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/575	77/9376	2.75297571993224	VEGFA/NFKB1/PIK3R1/GADD45G/AKT3/RALGDS/STAT3/BRAF/TGFB2/RAF1/BRCA2/MAP2K1/MAPK8	3.94781406151489
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	12/575	68/9376	2.87754475703325	PPARD/ZBTB16/NFKB1/PIK3R1/AKT3/TCF7L2/STAT3/SOS2/BRAF/RAF1/MAP2K1/RUNX1	3.97164220973633
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	15/575	98/9376	2.49582963620231	FCGR2B/GAB2/PLCG2/PIK3R1/PTPRC/AKT3/PLA2G4A/PRKCE/PLA2G4C/VAV3/SYK/INPP5D/RAF1/MAP2K1/DNM2	3.80470980189232
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	15/575	99/9376	2.47061923583663	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/FCGR2B/FPR3/HLA-DMA/HLA-DMB/C5AR1/HLA-DOA/CFH	3.75982482729231
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/575	70/9376	2.79532919254658	RAPGEF1/VEGFA/JUN/PIK3R1/AKT3/GAB1/SOS2/BRAF/TGFB2/RAF1/MAP2K1/CREBBP	3.85358673755607
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	14/575	90/9376	2.53650241545894	NFKBIA/NFATC1/NFKB1/TLR2/JUN/PIK3R1/JAK2/AKT3/FOS/MAP2K3/STAT3/NFATC3/RAF1/MAP2K1	3.74363684036918
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	18/575	134/9376	2.19036988968202	KCNMA1/MYH11/ACTG2/GNAQ/GNA13/ADM/PLA2G4A/PRKCE/ACTA2/PLA2G4C/PRKCH/GNA12/BRAF/MYL9/ITPR1/RAF1/MAP2K1/KCNMB1	3.5473570220653
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/575	73/9376	2.68045265038714	FOXO3/PLCG2/PIK3R1/FHIT/GADD45G/AKT3/STAT3/SOS2/BRAF/STK4/RAF1/MAP2K1	3.68408591485228
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	14/575	93/9376	2.45467975689575	GNAQ/JUN/PTK2B/PLA2G4A/HBEGF/PLA2G4C/MAP2K3/MAP3K2/SOS2/ITPR1/RAF1/MAP2K1/MAPK8/EGR1	3.60344787636279
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	28/575	253/9376	1.80462622443719	FOXO1/ELMO1/FOXO3/NFKBIA/RIPK2/CYTH1/BCL2/NFKB1/SEPTIN6/IL1B/PLCG2/JUN/PIK3R1/FNBP1/UBE2D1/MALT1/IL18/CGAS/AKT3/PRKCE/NAIP/RPS6KA5/MYL9/ITPR1/RIPK1/RPTOR/CXCL8/MAPK8	3.31618809776611
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	15/575	106/9376	2.30746513535685	FOXO1/HSP90AA1/NFKBIA/BCL2/NFKB1/CREB5/CTNNB1/PIK3R1/AKT3/TCF7L2/SOS2/BRAF/RAF1/MAP2K1/CREBBP	3.46016439134201
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	21/575	174/9376	1.967976011994	HSPA1B/HSPH1/DNAJB1/HSPA6/PPP1R15A/HSPA1A/HSP90AA1/CRYAB/ERO1B/DNAJA1/BCL2/ATF6/DNAJC5/HSPA1L/UBE2D1/EIF2AK3/NFE2L2/MAN1A1/HERPUD1/MAPK8/NGLY1	3.29421283259312
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	24/575	212/9376	1.84597210828548	DOCK4/SIPA1L1/RAPGEF1/THBS1/VEGFA/GNAQ/CTNNB1/TIAM1/FLT1/PIK3R1/INSR/AKT3/LCP2/VAV3/MAP2K3/RAPGEF2/RALGDS/BRAF/APBB1IP/SIPA1L2/RAF1/MAP2K1/MRAS/FARP2	3.18445403685736
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	14/575	99/9376	2.30591128678085	GPCPD1/JUN/DGKD/PIK3R1/CHKA/AKT3/FOS/PLA2G4A/PLA2G4C/RALGDS/SOS2/RAF1/MAP2K1/MAPK8	3.33872803961157
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/575	110/9376	2.22355731225296	HSP90AA1/PIK3R1/STK10/SPDYA/CPEB3/AKT3/CPEB4/MAD1L1/BRAF/RPS6KA2/RAF1/MAP2K1/MAPK8/PDE3B/CPEB2	3.29934751506031
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	10/575	59/9376	2.76374355195284	FOXO3/CTNNB1/PIK3R1/GADD45G/AKT3/TCF7L2/SOS2/BRAF/RAF1/MAP2K1	3.47357713344073
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/575	50/9376	2.93509565217391	THBS1/TLR2/IL1B/SDC2/IL18/CSF3/ACKR1/TGFB2/CXCL8	3.50665696698609
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	14/575	100/9376	2.28285217391304	CXCR4/CCL21/CCL20/IL6R/CXCL3/CCL14/TNFRSF10D/CXCL2/CXCL12/IL18/IL2RA/CCL18/CXCL8/IL10RA	3.29647506133263
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	16/575	122/9376	2.13850320741269	FOXO1/THRB/SLC16A10/PLCG2/MED13L/CTNNB1/ATP1B3/PIK3R1/ESR1/AKT3/NCOA2/ATP2A2/NCOA1/RAF1/MAP2K1/CREBBP	3.23521372428029
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	16/575	122/9376	2.13850320741269	IRS2/CREB5/GNAQ/PLCG2/PIK3R1/JAK2/AKT3/FOS/MAP2K3/STAT3/SOS2/ITPR1/RAF1/MAP2K1/MAPK8/CREBBP	3.23521372428029
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/575	71/9376	2.52629516227802	NFKBIA/NFKB1/CXCL3/PLCG2/JUN/ADAM17/CXCL2/HBEGF/MAP3K14/CXCL8/MAPK8	3.29961343589381
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	9/575	52/9376	2.82220735785953	APOA2/APOC3/ABCA1/APOB/APOA1/APOE/APOC1/MYLIP/APOC2	3.36784337026325
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	14/575	103/9376	2.21636133389616	NFKBIA/NFKB1/SERPINE1/TLR2/IL1B/GNAQ/JUN/PIK3R1/AKT3/FOS/CFLAR/TGFB2/CXCL8/MAPK8	3.17266807629677
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/575	62/9376	2.63001402524544	RBPJ/NCOR2/ADAM17/ATXN1/CTBP2/SPEN/HES1/MAML3/MAML2/CREBBP	3.29133902550377
NA	NA	hsa04517	IgSF CAM signaling	30/575	299/9376	1.63606223644031	FOXO1/ITGAX/MYH11/CADM1/PLCG2/CTNNB1/EPB41L3/PIK3R1/MBP/JAML/SORBS1/IL1RAP/AKT3/LCP2/VAV3/EZR/SRGAP2/RAPGEF2/CABLES1/TRIO/KCNQ3/NPHS1/MYL9/CD2AP/INPP5D/SRGAP1/MAP2K1/MAPK8/SRGAP3/RASA1	2.85704833920069
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	22/575	201/9376	1.78474583603721	FOXO1/REL/ZBTB16/ETV6/FUS/NFKB1/JMJD1C/FLT1/AFF1/GADD45G/TRAF1/BCL6/CDK14/PBX3/MITF/NFKBIZ/PPARG/CCNT2/CXCL8/KDM6A/FLI1/RUNX1	2.87460093335126
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	14/575	109/9376	2.09435979258077	NFKBIA/NFKB1/TLR2/IL1B/TRAF3/JUN/PIK3R1/AKT3/FOS/MAP2K3/RIPK1/CXCL8/MAP2K1/MAPK8	2.93736114606436
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	14/575	109/9376	2.09435979258077	FOXO1/PRKAG2/NFKBIA/IRS2/NFKB1/CREB5/PIK3R1/INSR/AKT3/PRKCE/PTPN1/STAT3/RPS6KA2/MAPK8	2.93736114606436
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	19/575	168/9376	1.84414078674948	MCL1/IL3RA/STAT4/BCL2/IL6R/PIK3R1/CSF2RA/CSF3R/JAK2/AKT3/IL2RA/CSF3/IL4R/STAT3/SOS2/RAF1/CREBBP/IL10RA/IL15	2.8218922082872
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	13/575	99/9376	2.14120333772508	IL1B/GNAQ/PLCG2/PIK3R1/IL1RAP/PLA2G4A/PRKCE/PLA2G4C/MAP2K3/PRKCH/ITPR1/MAPK8/PTGER4	2.91763125193084
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	18/575	160/9376	1.8344347826087	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/CADM1/HLA-DMA/ALCAM/SDC2/HLA-DMB/JAML/PTPRC/HLA-DOA/CD58/VSIR	2.72103862918821
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/575	70/9376	2.32944099378882	ACSL1/PRKAG2/NFKBIA/IRS2/NFKB1/JAK2/AKT3/ADIPOR2/STAT3/MAPK8	2.85358039255245
Organismal Systems	Immune system	hsa04611	Platelet activation	15/575	126/9376	1.94120082815735	PIK3R5/GNAQ/PLCG2/GNA13/PIK3R1/TBXAS1/AKT3/PLA2G4A/LCP2/PLA2G4C/VWF/GP6/APBB1IP/SYK/ITPR1	2.71863095062279
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	9/575	60/9376	2.44591304347826	VEGFA/PLCG2/PIK3R1/PTGS2/AKT3/PLA2G4A/PLA2G4C/RAF1/MAP2K1	2.87181599994243
Organismal Systems	Nervous system	hsa04730	Long-term depression	9/575	60/9376	2.44591304347826	GNAQ/GNA13/PLA2G4A/PLA2G4C/GNA12/BRAF/ITPR1/RAF1/MAP2K1	2.87181599994243
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	25/575	250/9376	1.63060869565217	TFRC/HSPA1B/CXCR4/HSPA6/HSPA1A/CYTH1/SMAP2/RAB7A/RAB31/AGAP3/IQSEC1/HSPA1L/CBL/IL2RA/USP8/AP2A2/MVB12B/PSD3/ARFGAP3/CBLB/ARAP2/VPS37B/DNM2/GRK3/WASHC2C	2.58311223954401
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	16/575	140/9376	1.86355279503106	PRKAG2/SLC8A1/PIK3R5/SERPINE1/GNAQ/GNA13/AKT3/PRKCE/ACTA2/MEF2D/ITPR1/RAF1/MAP2K1/MRAS/EGR1/PDE3B	2.6312644606739
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	21/575	203/9376	1.68683658170915	RAPGEF1/THBS1/EMP1/VEGFA/BCL2/JUN/CTNNB1/FLT1/PIK3R1/AKT3/EMP2/VAV3/VWF/PARVB/SOS2/BRAF/MYL9/RAF1/MAP2K1/MAPK8/TNC	2.52871153929772
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/575	154/9376	1.80002258610954	CAMK1D/PRKAG2/PIK3R5/NFATC1/GNAQ/JUN/PTGS2/FOS/PLA2G4A/PLA2G4C/NFATC3/MYL9/ITPR1/RAF1/MAP2K1/OXTR/CD38	2.55860709367192
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	16/575	142/9376	1.83730557256583	HSP90AA1/VEGFA/BCL2/NFKB1/IL1B/SDC2/JUN/CTNNB1/PIK3R1/THBD/DUSP1/AKT3/NFE2L2/FOS/MAPK8/IL1A	2.5697257046518
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	28/575	298/9376	1.53211555296177	CXCR4/IL1RL1/CCL21/IL3RA/CCL20/IL1B/IL6R/CXCL3/CCL14/CSF2RA/TNFRSF10D/CSF3R/IL1RAP/CXCL2/CXCL12/IL18/INHBA/IL2RA/CSF3/IL4R/RELT/TGFB2/CCL18/CXCL8/IL1RN/IL10RA/IL1A/IL15	2.38601157281802
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	6/575	34/9376	2.87754475703325	PER1/PRKAG2/CRY2/NFIL3/BHLHE40/NR1D2	2.80325997132987
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	12/575	99/9376	1.9764953886693	BCL2/JUN/PIK3R1/ESR1/AKT3/FOS/HBEGF/SOS2/BRAF/RAF1/MAP2K1/MAPK8	2.49653446425011
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	16/575	148/9376	1.76282021151586	JUN/CTNNB1/PIK3R1/GADD45G/ESR1/AKT3/FOS/WNT5B/HES1/TCF7L2/SOS2/BRAF/NCOA1/RAF1/BRCA2/MAP2K1	2.39085262393441
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	14/575	125/9376	1.82628173913043	GAB2/BCL2/NFKB1/GNAQ/GNA13/PIK3R1/AKT3/PRKCE/CERS6/GNA12/RAF1/MAP2K1/MAPK8/ADORA3	2.37707218924439
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	21/575	214/9376	1.60013002844372	CXCR4/NFKBIA/BCL2/NFATC1/NFKB1/TLR2/GNAQ/PLCG2/JUN/PTK2B/PIK3R1/CGAS/AKT3/FOS/MAP2K3/NFATC3/ITPR1/RIPK1/RAF1/MAP2K1/MAPK8	2.26992052018604
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	32/575	362/9376	1.44142205140524	NR4A1/THBS1/MCL1/HSP90AA1/FOXO3/IL3RA/VEGFA/PIK3R5/EREG/BCL2/NFKB1/SGK1/CREB5/TLR2/IL6R/PHLPP1/FLT1/PIK3R1/INSR/CSF3R/JAK2/AKT3/IL2RA/VWF/CSF3/IL4R/SOS2/SYK/RAF1/RPTOR/MAP2K1/TNC	2.18928894045797
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	6/575	37/9376	2.6442303172738	CTNNB1/GADD45G/TCF7L2/PPARG/BRAF/MAP2K1	2.56133790185182
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	12/575	105/9376	1.86355279503106	ARIH1/FOXO3/JUN/RAB7A/GABARAPL1/RABGEF1/EIF2AK3/MITF/USP8/USP15/MAPK8/MRAS	2.27443643169845
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	22/575	232/9376	1.54626686656672	IQGAP2/CXCR4/ITGAX/MYH11/RGCC/GNA13/TIAM1/PIK3R1/CXCL12/AKT3/VAV3/SSH2/EZR/GNA12/PIKFYVE/SOS2/BRAF/MYL9/RAF1/DIAPH2/MAP2K1/MRAS	2.15344752453008
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	16/575	157/9376	1.66176682359457	PRKAG2/IRS2/NFKB1/IL1B/IL6R/JUN/PIK3R1/INSR/EIF2AK3/AKT3/FOS/ADIPOR2/PPARG/CXCL8/MAPK8/IL1A	2.13730479267377
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	23/575	250/9376	1.50016	SLC11A1/OSBPL3/DMXL2/RAB7A/LITAF/CLN8/GLA/CTSH/MANBA/TPCN1/MITF/AP2A2/OSBPL1A/DMXL1/PSAP/ARSG/PIKFYVE/CTSB/GPR155/RPTOR/AP3B1/ACP5/AP4S1	2.04876562381395
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	13/575	122/9376	1.73753385602281	FOXO1/PRKAG2/PFKFB3/FOXO3/IRS2/CREB5/PIK3R1/INSR/AKT3/ADIPOR2/PPARG/SIRT1/RPTOR	2.09580406764848
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	21/575	226/9376	1.51516737206618	PDE4B/NFKBIA/NFATC1/NFKB1/CREB5/JUN/ATP1B3/TIAM1/PIK3R1/AKT3/FOS/VAV3/ATP2A2/BRAF/MYL9/RAF1/MAP2K1/MAPK8/OXTR/PDE3B/CREBBP	2.00375939636011
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	21/575	227/9376	1.50849262593373	MT-ATP8/FOXO3/VEGFA/NFKBIA/SOD2/NFKB1/JUN/ABL2/MT-ND4L/PIK3R1/AHR/AKT3/NFE2L2/FOS/PTPN1/SOS2/BRAF/RAF1/MAP3K14/MAP2K1/MAPK8	1.98227691845927
Human Diseases	Cancer: specific types	hsa05214	Glioma	9/575	76/9376	1.93098398169336	CAMK1D/PLCG2/PIK3R1/GADD45G/AKT3/SOS2/BRAF/RAF1/MAP2K1	2.08286480016261
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/575	78/9376	1.88147157190635	ELMO1/SEPTIN6/CTNNB1/PIK3R1/ARHGAP10/CBL/GAB1/CD2AP/DNM2	1.99808698538125
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/575	23/9376	2.83584120982987	ATP1B3/GLS/GLUD1/CA2	2.25308260858308
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/575	103/9376	1.74142676234698	NFKB1/TLR2/IL1B/GNAQ/CXCL3/RAB7A/PIK3R1/CXCL2/SERPINB9/TGFB2/CXCL8	1.93388342284412
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	13/575	130/9376	1.63060869565217	VEGFA/NFKBIA/NFKB1/CREB5/JUN/PIK3R1/AKT3/FOS/ACTA2/SOS2/RAF1/MAP2K1/MAPK8	1.85058158713124
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	10/575	93/9376	1.75334268349696	NFKBIA/BCL2/NFKB1/TRAF3/PIK3R1/FHIT/GADD45G/TRAF1/PTGS2/AKT3	1.86613657071405
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	27/575	323/9376	1.36304751648943	TIMP3/THBS1/MCL1/VEGFA/IRS2/FOXP1/BCL2/NFKB1/EZH2/PLCG2/PIK3R1/PTGS2/SLC7A1/PRKCE/EZR/ZEB2/RPS6KA5/STAT3/GLS/SOS2/SIRT1/TGFB2/RAF1/RPTOR/MAP2K1/CREBBP/TNC	1.69715700587716
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	11/575	107/9376	1.67632669646485	FOXO1/PRKAG2/CREB5/GNAQ/AKT3/SIRT1/ITPR1/PDE3B/CREBBP/PHKA2/PPP4R3B	1.79839682999958
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	18/575	200/9376	1.46754782608696	MYH11/NFKBIA/CYTH1/NFKB1/IL1B/GNA13/JUN/IL18/MYO5A/FOS/EZR/GNA12/NAIP/ABI1/RIPK1/MYO1F/CXCL8/MAPK8	1.70831473728414
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/575	59/9376	1.93462048636699	IRS2/PIK3R1/INSR/PTGS2/AKT3/MGLL/PDE3B	1.84067368881098
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	8/575	73/9376	1.78696843359142	ELL2/CXCR4/ELL/AFF4/RANBP2/CCNT2/CREBBP/SERINC5	1.72528474453571
Organismal Systems	Digestive system	hsa04978	Mineral absorption	7/575	61/9376	1.8711903064861	TF/MT1G/SLC8A1/MT1M/ATP1B3/MT1H/MT1A	1.74477758163871
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/575	17/9376	2.87754475703325	GLUL/GLUD1/CA2	1.98040304601663
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	9/575	88/9376	1.66766798418972	ITGAX/SERPINE1/THBD/C5AR1/PLAUR/CD55/VWF/CFH/SERPINF2	1.60840099958642
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	15/575	168/9376	1.45590062111801	TNFAIP3/HSP90AA1/STAT4/BCL2/IL1B/JAK2/PLA2G4A/GLUL/CFLAR/PLA2G4C/STAT3/GLUD1/RIPK1/MAPK8/IL1A	1.52403773242628
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	8/575	76/9376	1.71643020594966	APOA2/ACSL1/APOC3/PPARD/OLR1/APOA1/SORBS1/PPARG	1.60284955175231
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	12/575	128/9376	1.52869565217391	PDE4B/AMPD3/FHIT/PDE8A/PAPSS2/ADA/NT5C2/PDE2A/ADK/ENTPD1/PDE3B/PDE7A	1.53936058820936
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	20/575	238/9376	1.37025940811107	NFKBIA/NFKB1/TLR2/IL1B/IL6R/TRAF3/PLCG2/JUN/PIK3R1/ADAM17/C5AR1/CGAS/FOS/HBEGF/VWF/CSF3/STAT3/SYK/CXCL8/MAPK8	1.47884464908571
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	11/575	115/9376	1.55971266540643	PIK3R5/BCL2/CREB5/GNAQ/PIK3R1/JAK2/AKT3/FOS/KCNQ3/ITPR1/MAP2K1	1.54361383554208
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	11/575	115/9376	1.55971266540643	GNAQ/PTGS2/DUSP1/PLA2G4A/PLA2G4C/ALOX5/BRAF/ITPR1/RAF1/MAOB/MAP2K1	1.54361383554208
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	15/575	170/9376	1.43877237851662	PLCG2/CTNNB1/PIK3R1/GADD45G/AKT3/NFE2L2/WNT5B/TCF7L2/GAB1/SOS2/ARID2/BRAF/TGFB2/RAF1/MAP2K1	1.47564471119585
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	4/575	29/9376	2.24911544227886	LATS2/RASSF2/MOB1B/LIMD1	1.72194392685017
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	6/575	53/9376	1.84597210828548	SLC8A1/GNAQ/ATP1B3/ESR1/AP2A2/DNM2	1.57859123582266
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	8/575	78/9376	1.67241917502787	NFKB1/IL1B/JUN/IRF1/FOS/CXCL8/MAPK8/IL1A	1.52421478487195
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/575	42/9376	1.94120082815735	ACSL1/TFRC/TF/SAT1/ATG7	1.56252364339033
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	7/575	67/9376	1.70362102530824	GNAQ/BRAF/RPS6KA2/ITPR1/RAF1/MAP2K1/CREBBP	1.47733247485455
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	9/575	93/9376	1.57800841514727	CTNNB1/INSR/SORBS1/PTPN1/SNAI1/TCF7L2/MYL9/FARP2/CREBBP	1.43180874430186
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	18/575	217/9376	1.3525786415548	HSP90AA1/VEGFA/BCL2/NFKB1/CREB5/JUN/PIK3R1/ESR1/BCL6/JAK2/AHR/AKT3/FOS/STAT3/SOS2/RPS6KA2/RAF1/MAP2K1	1.34312176748127
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	13/575	150/9376	1.41319420289855	BCL2/CTNNB1/PIK3R1/GADD45G/AKT3/WNT5B/TCF7L2/GAB1/SOS2/BRAF/TGFB2/RAF1/MAP2K1	1.30390717220876
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	8/575	83/9376	1.5716710319539	SFMBT2/JARID2/L3MBTL4/EZH2/RYBP/UBE2D1/FOXK2/CREBBP	1.33709053216725
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	10/575	110/9376	1.48237154150198	TFRC/THBS1/TF/SKIL/INHBA/SKI/HAMP/LEMD3/TGFB2/CREBBP	1.30072480533002
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	9/575	98/9376	1.49749778172138	PLCG2/DGKD/PIK3R1/ITPKB/PIKFYVE/INPP5A/ITPR1/INPP5D/PI4K2A	1.26540793197591
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	9/575	98/9376	1.49749778172138	NR4A1/CAMK1D/CREB5/GNAQ/NR4A2/ATP1B3/PRKCE/PDE2A/ITPR1	1.26540793197591
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	7/575	72/9376	1.58531400966184	NFKBIA/NFKB1/TRAF3/TANK/RIPK1/CXCL8/MAPK8	1.27430640681093
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	15/575	184/9376	1.32930056710775	CXCR4/SEMA4A/PLCG2/PIK3R1/PLXNC1/CXCL12/WNT5B/SSH2/SRGAP2/NFATC3/MYL9/SRGAP1/RAF1/SRGAP3/RASA1	1.15305475835921
Human Diseases	Cancer: specific types	hsa05218	Melanoma	7/575	73/9376	1.5635973793925	PIK3R1/GADD45G/AKT3/MITF/BRAF/RAF1/MAP2K1	1.23558445195657
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	5/575	47/9376	1.73469010175763	IRS2/PIK3R1/INSR/PRKCE/MAPK8	1.29059245329531
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/575	156/9376	1.35884057971014	NFKBIA/NFKB1/TRAF3/CTNNB1/PIK3R1/AKT3/CFLAR/STAT3/SOS2/BRAF/RIPK1/RAF1/MAP2K1	1.15518605687009
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/575	23/9376	2.1268809073724	GLUL/GLS/GLUD1	1.38299312639374
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	13/575	158/9376	1.34164006604293	FNIP2/SLC7A5/SGK1/PIK3R1/INSR/AKT3/WNT5B/SOS2/BRAF/RPS6KA2/RAF1/RPTOR/MAP2K1	1.10696155697641
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	12/575	144/9376	1.35884057971014	JARID2/CTNNB1/SKIL/PIK3R1/JAK2/AKT3/WNT5B/ZFHX3/INHBA/STAT3/RAF1/MAP2K1	1.10914531169294
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	10/575	116/9376	1.40569715142429	SLC1A3/GNAQ/PLA2G4A/GLUL/PLA2G4C/SLC38A2/GLS/ITPR1/HOMER1/GRK3	1.12377407703041
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/575	75/9376	1.52190144927536	THBS1/BCL2/SERPINE1/GADD45G/SESN1/COP1/PPM1D	1.15986611907031
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/575	49/9376	1.66388642413487	FOSB/NFKB1/CREB5/JUN/MAOB	1.190897516268
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	9/575	104/9376	1.41110367892977	GPCPD1/DGKD/AGPAT4/CHKA/PLA2G4A/PLA2G4C/LPCAT1/PGS1/SAMD8	1.07754364886587
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/575	63/9376	1.55296066252588	KMT2E/EZH2/KMT2C/ASH1L/PRDM2/SETDB2	1.12557194599096
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/575	37/9376	1.76282021151586	IL1B/GNAQ/APOA1/IL18	1.18830087216355
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	11/575	133/9376	1.34862373324616	NFATC1/PLCG2/PTK2B/PIK3R1/LCP2/VAV3/SOS2/BRAF/SYK/RAF1/MAP2K1	1.03497496135487
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	7/575	78/9376	1.46336677814939	HSPD1/BTG1/TENT4A/TENT4B/CNOT1/PABPC1/PAN3	1.05034258436265
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/575	38/9376	1.71643020594966	NAMPT/NT5C2/SIRT1/CD38	1.13107733978619
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	4/575	38/9376	1.71643020594966	SGK1/ATP1B3/PIK3R1/INSR	1.13107733978619
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/575	65/9376	1.50517725752508	GNAQ/PIK3R1/AKT3/ITPR1/RAF1/MAP2K1	1.04461403358505
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/575	14/9376	2.32944099378882	ST3GAL1/B4GALT1	1.2723374657163
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/575	26/9376	1.88147157190635	APOB/APOA1/SLC19A2	1.15038372560273
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	5/575	52/9376	1.56789297658863	INSR/PTGS2/PLA2G4A/PLA2G4C/ALOX5	1.04959218168765
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	19/575	254/9376	1.21974666210202	CXCR4/CAMK1D/SLC8A1/VEGFA/NFATC1/GNAQ/PLCG2/PTK2B/FLT1/ITPKB/P2RX7/TPCN1/ATP2A2/NFATC3/ITPR1/MCU/OXTR/PHKA2/CD38	0.907502147411686
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	24/575	333/9376	1.17521347434391	FOXO1/THBS1/VEGFA/NFKB1/CREB5/RBPJ/TRAF3/CTNNB1/PIK3R1/PTGS2/AKT3/IRF1/WNT5B/VWF/HES1/TCF7L2/MAML3/SOS2/MAML2/RAF1/MAP2K1/CREBBP/PTGER4/TNC	0.832121805670336
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/575	15/9376	2.17414492753623	ST3GAL1/ST6GALNAC3	1.16321438204715
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	12/575	155/9376	1.26240673211781	NR4A1/CREB5/GNAQ/CTNNB1/PDE8A/AHR/WNT5B/USP8/TCF7L2/BRAF/ITPR1/MAP2K1	0.841986951001013
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/575	28/9376	1.74708074534161	ST3GAL6/B4GALT1/GCNT2	1.01190736592173
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/575	55/9376	1.48237154150198	GLA/CERS6/PSAP/ACER3/SAMD8	0.917033748113091
Organismal Systems	Endocrine system	hsa04924	Renin secretion	6/575	69/9376	1.41792060491493	KCNMA1/GNAQ/CTSB/ITPR1/PDE3B/PTGER4	0.890567869546778
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/575	69/9376	1.41792060491493	FOSB/CREB5/JUN/FOS/SIRT1/MAOB	0.890567869546778
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	4/575	42/9376	1.55296066252588	KMO/KYNU/AFMID/MAOB	0.917991233340718
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/575	16/9376	2.03826086956522	ST3GAL1/GLA	1.06238542383427
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	11/575	143/9376	1.2543143812709	HLA-DRB1/HLA-DRB5/HLA-DRA/HLA-DQB1/HLA-DPB1/HLA-DQA1/HLA-DPA1/HLA-DQA2/HLA-DMA/HLA-DMB/HLA-DOA	0.783287274386923
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	6/575	71/9376	1.37797917942437	SLC7A5/PIK3R1/AKT3/GLS/RAF1/MAP2K1	0.81713236714669
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	27/575	388/9376	1.13470192738682	MT-ATP8/IRS2/NFKB1/IL1B/GNAQ/CTNNB1/MT-ND4L/ATF6/PIK3R1/INSR/ADAM17/APOE/PTGS2/EIF2AK3/AKT3/WNT5B/DKK1/SLC39A10/ATP2A2/SLC39A11/BRAF/ITPR1/MCU/RAF1/MAP2K1/MAPK8/IL1A	0.692646574671899
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	8/575	101/9376	1.29157124408093	GNAQ/CTNNB1/WNT5B/MITF/TCF7L2/RAF1/MAP2K1/CREBBP	0.753012122285289
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/575	17/9376	1.9183631713555	TFRC/MYH11	0.968674230049107
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	9/575	116/9376	1.26512743628186	CXCR4/PLCG2/PTK2B/CTNNB1/PIK3R1/CXCL12/VAV3/EZR/MYL9	0.734398402742267
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	13/575	178/9376	1.19089399120664	PPARD/NFATC1/JUN/CTNNB1/CTBP2/FOSL1/WNT5B/DKK1/TCF7L2/SIRT1/NFATC3/MAPK8/CREBBP	0.6572174815354
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/575	18/9376	1.81178743961353	MANBA/ENGASE	0.881131261111447
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/575	195/9376	1.17069342251951	FPR3/NFKB1/TLR2/PLCG2/PIK3R1/C5AR1/ATG7/AKT3/AQP9/VWF/SYK/RAF1/CLEC7A/MAP2K1	0.615662424718911
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	6/575	75/9376	1.30448695652174	ALB/CREB5/GNAQ/GPX3/ATP1B3/ITPR1	0.676687342138542
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/575	32/9376	1.52869565217391	GLA/B4GALT1/GALM	0.76571624906827
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	3/575	32/9376	1.52869565217391	GABARAPL1/ATG7/RPTOR	0.76571624906827
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/575	48/9376	1.35884057971014	ATP1B3/PIK3R1/AKT3/SLC2A5	0.637061631724237
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	5/575	63/9376	1.29413388543823	TBXAS1/PTGS2/PLA2G4A/PLA2G4C/ALOX5	0.598720437548483
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	6/575	78/9376	1.2543143812709	PLCG2/ITPKB/PIKFYVE/INPP5A/INPP5D/PI4K2A	0.576470383853354
NA	NA	hsa04518	Integrin signaling	11/575	154/9376	1.16472049689441	ITGAX/THBS1/VEGFA/LIMS1/CTNNB1/FLT1/PIK3R1/AKT3/VWF/PARVB/TNC	0.526803916720288
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/575	20/9376	1.63060869565217	UAP1/CYB5R4	0.721578187309262
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	4/575	50/9376	1.30448695652174	P4HA1/SAT1/AMD1/MAOB	0.551771849750086
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	5/575	65/9376	1.2543143812709	NR4A1/CREB5/GNAQ/PDE8A/ITPR1	0.525875556868066
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	14/575	205/9376	1.11358642629905	REL/NFKBIA/NFKB1/CREB5/RBPJ/TRAF3/JUN/PIK3R1/TRAF1/MAD1L1/RASA2/STAT3/SYK/CREBBP	0.420289528462492
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	3/575	36/9376	1.35884057971014	ST3GAL1/GALNT15/ST6GALNAC3	0.551357024378425
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/575	37/9376	1.3221151586369	GLUL/GLS/GLUD1	0.501782357319417
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	6/575	83/9376	1.17875327396543	NFKBIA/NFKB1/IL1B/IL18/CGAS/RIPK1	0.4180888952798
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	3/575	38/9376	1.28732265446224	CIITA/PTPRC/ADA	0.453615915368448
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	6/575	85/9376	1.1510179028133	AMPD3/UPP1/ADA/NT5C2/ADK/ENTPD1	0.357486970751693
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/575	102/9376	1.11904518329071	KCNMA1/GNAQ/ATP1B3/ATP2A2/ITPR1/CA2/CD38	0.308981102281659
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	2/575	24/9376	1.35884057971014	HS3ST2/XYLT1	0.449892208061877
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	7/575	103/9376	1.10818066694808	FUS/NXF1/PCF11/SMG1/EIF4A3/PABPC1/PAPOLG	0.282170551573917
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	4/575	56/9376	1.16472049689441	MAN2A1/B4GALT1/MAN1A1/DHRSX	0.316000122572396
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	15/575	233/9376	1.04974808732973	DES/TTN/THBS1/MYH11/AMPD3/ACTG2/FMNL2/SDC2/ATP1B3/CSRP1/FMNL1/FMNL3/MYL9/DIAPH2/SYNE2	0.196545696328515
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	6/575	89/9376	1.09928676111383	GNAQ/MAP3K2/SOS2/ITPR1/RAF1/MAP2K1	0.240548234732721
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	1/575	10/9376	1.63060869565217	PAPSS2	0.50996037099194
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	11/575	170/9376	1.05509974424552	MYH11/PRKAG2/JUN/TIAM1/PRKCE/EZR/RAPGEF2/YBX3/MYL9/MAPK8/RUNX1	0.185307120879013
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	10/575	154/9376	1.05883681535855	SLC8A1/KCNE1/PIK3R5/BCL2/CREB5/GNAQ/ATP1B3/AKT3/ATP2A2/RPS6KA5	0.188170053895016
NA	NA	hsa04081	Hormone signaling	14/575	219/9376	1.04239825292833	THRB/IRS2/SLC16A10/GNAQ/GNA13/PIK3R1/INSR/ESR1/JAK2/ADIPOR2/GNA12/STAT3/HAMP/OXTR	0.162273260248406
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/575	26/9376	1.2543143812709	PLA2G4A/PLA2G4C	0.331898537315343
Human Diseases	Substance dependence	hsa05032	Morphine addiction	6/575	91/9376	1.07512661251792	PDE4B/PDE8A/PDE2A/PDE3B/GRK3/PDE7A	0.184067493727538
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/575	59/9376	1.10549742078113	DPYD/UPP1/NT5C2/ENTPD1	0.207770244181238
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	3/575	43/9376	1.13763397371082	ABCA1/APOB/APOA1	0.231207966338754
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	5/575	76/9376	1.07276887871854	GNAQ/ATP1B3/EZR/ITPR1/CA2	0.162803806521411
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	9/575	142/9376	1.03348438456828	HERC1/UBE2D1/UBR5/CBL/UBE2E1/COP1/CUL3/CBLB/UBE2E2	0.102764972011205
Organismal Systems	Digestive system	hsa04970	Salivary secretion	6/575	93/9376	1.05200561009818	KCNMA1/GNAQ/ATP1B3/LYZ/ITPR1/CD38	0.128825265065304
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/575	44/9376	1.11177865612648	MAN2A1/B4GALT1/MAN1A1	0.189955296386796
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	9/575	144/9376	1.01913043478261	RBPJ/GNAQ/PIK3R1/ATXN1/AKT3/ATP2A2/ITPR1/MCU/MAPK8	0.0591305255022083
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/575	12/9376	1.35884057971014	FCGR2B	0.317917928636325
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/575	63/9376	1.03530710835059	CTNNB1/GADD45G/WNT5B/TCF7L2	0.0718689291060075
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/575	30/9376	1.08707246376812	PLA2G4A/PLA2G4C	0.122090570283467
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/575	30/9376	1.08707246376812	NFKB1/IL1B	0.122090570283467
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	4/575	65/9376	1.00345150501672	DGKD/AGPAT4/GLA/MGLL	0.0071370801510764
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	6/575	99/9376	0.988247694334651	DES/TTN/PRKAG2/SLC8A1/ATP2A2/TGFB2	-0.0300462618343016
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/575	31/9376	1.05200561009818	GLUL/AFMID	0.0741301603823324
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	2/575	32/9376	1.01913043478261	BCL2/MAPK8	0.027706837959707
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	2/575	33/9376	0.988247694334651	STX11/STX5	-0.0172858374227509
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/575	51/9376	0.959181585677749	PLA2G4A/PLA2G4C/LPCAT1	-0.0747085568982416
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/575	15/9376	1.08707246376812	TPK1	0.0862618742882801
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	5/575	86/9376	0.948028311425682	KCNMA1/CREB5/GNAQ/ATP1B3/KCNMB1	-0.123754712641403
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	5/575	86/9376	0.948028311425682	DES/SLC8A1/CTNNB1/ATP2A2/TCF7L2	-0.123754712641403
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/575	138/9376	0.945280403276623	SPDYA/CPEB3/CPEB4/MAD1L1/RPS6KA2/ITPR1/MAP2K1/CPEB2	-0.16551867547171
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	9/575	157/9376	0.934743838271947	SERPINE1/LATS2/CTNNB1/WNT5B/TCF7L2/MOB1B/TP53BP2/TGFB2/LIMD1	-0.210757478676976
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	1/575	16/9376	1.01913043478261	MAOB	0.0195749408076666
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/575	35/9376	0.931776397515528	PFKFB3/ALDOB	-0.103353582356523
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	5/575	89/9376	0.916072300928187	GABARAPL1/GLUL/SLC38A2/PLCL1/GLS	-0.203336876240315
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	3/575	54/9376	0.905893719806763	MAT2A/SDS/AMD1	-0.177261527645276
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	3/575	54/9376	0.905893719806763	HES1/BRCA2/REV3L	-0.177261527645276
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	1/575	17/9376	0.959181585677749	PAPSS2	-0.0430545859184129
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	3/575	56/9376	0.873540372670807	BCL2/CUL3/GRK3	-0.242600395760709
NA	NA	hsa04519	Cadherin signaling	23/575	404/9376	0.928316831683168	FMN1/DES/NFKBIA/NFKB1/LATS2/PTK2B/CTNNB1/TAOK3/WNT5B/VAV3/MAP2K3/RERE/TCF7L2/MOB1B/ERBIN/LHFPL2/RAF1/MYO1F/LIMD1/MAP2K1/MAPK8/MRAS/CREBBP	-0.376458227040986
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	1/575	18/9376	0.905893719806763	ACSL1	-0.102144947431867
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	4/575	75/9376	0.869657971014493	MAT2A/SDS/GLUL/ALDOB	-0.289670211724983
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	4/575	75/9376	0.869657971014493	BCL2/PIK3R1/AKT3/REV3L	-0.289670211724983
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	27/575	480/9376	0.917217391304348	MT-ATP8/FUS/BCL2/NFKB1/IL1B/GNAQ/GPX3/CTNNB1/MT-ND4L/ATF6/HIP1/C9orf72/PTGS2/ATXN1/EIF2AK3/WNT5B/MAP2K3/DKK1/ATP2A2/BRAF/TANK/ITPR1/MCU/RAF1/MAP2K1/MAPK8/IL1A	-0.475900202558292
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	7/575	133/9376	0.858215102974828	CREB5/GNAQ/AKT3/FOS/ITPR1/MAOB/MAPK8	-0.420923202654473
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	5/575	97/9376	0.840519946212461	PER1/GNAQ/FOS/RPS6KA5/ITPR1	-0.403548003730712
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	15/575	275/9376	0.889422924901186	MT-ATP8/HSPA1B/HSPA6/HSPA1A/CREB5/IL1B/MT-ND4L/PIK3R1/HSPA1L/EIF2AK3/ITPR1/MCU/MAPK8/EGR1/IL1A	-0.475707981244121
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/575	41/9376	0.79541887592789	SDS/MAOB	-0.335547399813166
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/575	41/9376	0.79541887592789	RBBP8/BRCA2	-0.335547399813166
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/575	21/9376	0.77648033126294	DPYD	-0.262093980494092
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/575	22/9376	0.741185770750988	MAOB	-0.310637839662084
Cellular Processes	Cell motility	hsa04814	Motor proteins	10/575	194/9376	0.840519946212461	MYH11/ACTG2/MYO9B/KIF13B/MYO5A/ACTA2/KIF1B/MYL9/MYO1F/DYNC1H1	-0.57370963590692
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	8/575	158/9376	0.825624656026417	GADD45G/CCNH/STAG1/MAD1L1/STAG2/TGFB2/NIPBL/CREBBP	-0.56500048281527
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/575	44/9376	0.741185770750988	CCNH/TAF4B	-0.439825771124731
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	2/575	44/9376	0.741185770750988	CREB5/DYNC1H1	-0.439825771124731
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/575	23/9376	0.708960302457467	B4GALT1	-0.357185837984936
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	2/575	45/9376	0.724714975845411	ABCA1/ABCG1	-0.473127615962826
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	5/575	105/9376	0.77648033126294	DES/TTN/SLC8A1/ATP2A2/TGFB2	-0.588708971474586
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	16/575	308/9376	0.847069452286844	MT-ATP8/SLC1A3/SOD2/CREB5/GNAQ/RCOR1/GPX3/POLR2A/MT-ND4L/HIP1/TAF4B/AP2A2/PPARG/ITPR1/MAPK8/CREBBP	-0.697537236630622
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	4/575	89/9376	0.73285784074255	THBS1/VWF/GP6/TNC	-0.647221987213351
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/575	26/9376	0.627157190635452	HES1	-0.486586650972047
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	2/575	49/9376	0.665554569653948	B4GALT1/GALNT15	-0.599937305308384
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	10/575	205/9376	0.79541887592789	MT-ATP8/NFKB1/MT-ND4L/PIK3R1/INSR/AKT3/PDK4/ATP2A2/TGFB2/MAPK8	-0.756985732980282
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	1/575	27/9376	0.603929146537842	ELOVL5	-0.526775704308464
Genetic Information Processing	Transcription	hsa03040	Spliceosome	12/575	243/9376	0.805238862050456	HSPA1B/HSPA6/HSPA1A/FUS/RBM25/TRA2B/HSPA1L/HNRNPC/SRSF7/EIF4A3/HNRNPU/BCAS2	-0.786234798056799
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	1/575	28/9376	0.582360248447205	ELOVL5	-0.565685494550858
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/575	28/9376	0.582360248447205	GCH1	-0.565685494550858
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/575	28/9376	0.582360248447205	CA2	-0.565685494550858
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/575	31/9376	0.526002805049088	ALDOB	-0.675648031359576
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	1/575	31/9376	0.526002805049088	DPYD	-0.675648031359576
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	1/575	31/9376	0.526002805049088	IMMP2L	-0.675648031359576
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	11/575	235/9376	0.763263644773358	MT-ATP8/ACSL1/PRKAG2/CREB5/MT-ND4L/MAP2K3/MGLL/PPARG/SOS2/RPS6KA2/RPTOR	-0.939410875506398
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	3/575	79/9376	0.619218492019813	SLC1A3/AP2A2/DNM2	-0.868703416718897
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	2/575	57/9376	0.572143401983219	ACSL1/ELOVL5	-0.82814151343909
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/575	103/9376	0.633246095398902	SLC8A1/SLC16A10/ATP1B3/SLC38A2	-0.956614101878734
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	1/575	34/9376	0.479590792838875	POLR2A	-0.776994686108813
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	6/575	149/9376	0.656620951269332	GNAQ/MT-ND4L/PTGS2/MGLL/ITPR1/MAPK8	-1.07991660025343
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	12/575	268/9376	0.730123296560675	MT-ATP8/MT-ND4L/ATF6/DUSP1/EIF2AK3/NFE2L2/SLC39A10/SLC39A11/ITPR1/MCU/MAOB/MAPK8	-1.14571034018038
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/575	37/9376	0.440705052878966	MAOB	-0.871254672368853
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	1/575	37/9376	0.440705052878966	UAP1	-0.871254672368853
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	4/575	108/9376	0.603929146537842	NUP98/NXF1/RANBP2/EIF4A3	-1.05814528092026
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	2/575	63/9376	0.517653554175293	POLR2A/CCNH	-0.981834087778944
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	3/575	87/9376	0.562278860569715	SLC8A1/ATP1B3/ATP2A2	-1.04839807772398
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	1/575	38/9376	0.429107551487414	UAP1	-0.901306933467031
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	1/575	39/9376	0.418104793756968	MAT2A	-0.930736945595415
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/575	154/9376	0.635302089215133	KMO/MAT2A/KYNU/GCH1/AFMID/TPK1	-1.16636539740607
Organismal Systems	Digestive system	hsa04976	Bile secretion	3/575	90/9376	0.543536231884058	ATP1B3/AQP9/CA2	-1.11215873233897
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	2/575	67/9376	0.486748864373783	GALM/ALDOB	-1.07762921110042
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/575	117/9376	0.557473058342624	BAZ1A/GATAD2A/ARID2/INO80	-1.23113068290094
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	1/575	43/9376	0.379211324570273	ACSL1	-1.04284780350677
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/575	44/9376	0.370592885375494	POLG2	-1.06960683863626
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/575	46/9376	0.354480151228733	PSME4	-1.12176334482657
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	16/575	368/9376	0.708960302457467	MT-ATP8/FUS/NUP98/BCL2/GPX3/NXF1/MT-ND4L/ATF6/C9orf72/EIF2AK3/RANBP2/SRSF7/MAP2K3/HNRNPA2B1/TANK/MCU	-1.45584621274757
Human Diseases	Substance dependence	hsa05034	Alcoholism	7/575	191/9376	0.597605281129069	FOSB/CREB5/SOS2/BRAF/RAF1/MAOB/MAP2K1	-1.4360941915393
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	1/575	51/9376	0.319727195225916	PLCG2	-1.24508020180703
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/575	82/9376	0.397709437963945	DPYD/UPP1	-1.40011980857529
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	2/575	83/9376	0.392917757988476	ACSL1/SOD2	-1.41991437849509
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	1/575	59/9376	0.276374355195284	GPX3	-1.42513320044851
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	3/575	116/9376	0.421709145427286	SDS/GLUD1/ALDOB	-1.60185564298658
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/575	70/9376	0.232944099378882	PTGS2	-1.64644815996383
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/575	73/9376	0.223371054198928	MAOB	-1.70261730351829
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	2/575	138/9376	0.236320100819156	MT-ATP8/MT-ND4L	-2.31001858503793
NA	NA	hsa04082	Neuroactive ligand signaling	4/575	199/9376	0.327760541839633	SLC1A3/GNAQ/P2RY14/ADORA3	-2.44993026576918
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/575	183/9376	0.267312900926586	NXF1/NOP58/RCL1	-2.55840331740814
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	10/575	370/9376	0.440705052878966	THRB/FPR3/ADM/C5AR1/P2RX7/P2RY14/P2RY8/OXTR/PTGER4/ADORA3	-2.80562315103473
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/575	449/9376	0.108949356056938	SLC8A1/PDE2A/GRK3	-4.94568374372516