category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	86/2485	142/9376	2.28507949103069	UBE2E2/CBLB/MID1/HERC1/ANAPC5/UBE2H/BIRC6/UBE2J1/UBE2R2/UBE2E1/ANAPC16/NEDD4/HERC4/UBE2B/UBR5/UBE3C/CDC27/UBE2N/UBE2K/PIAS1/UBE2D2/CUL3/ELOC/UBC/UBA6/HUWE1/UBE2G1/CUL1/FBXW7/SMURF2/TRIP12/MAP3K1/UBE2D3/CUL5/FBXW11/STUB1/UBE2W/CUL4A/UBE2I/UBE2Z/SMURF1/UBA2/UBE2L6/ITCH/UBE2Q2/XIAP/UBE2G2/COP1/HERC2/UBE3A/UBE2E3/PRKN/UBE2Q1/PML/CDC26/CDC16/UBE4B/CBL/PIAS2/BTRC/ANAPC7/MDM2/SAE1/TRIM37/RHOBTB1/SIAH1/DDB2/MGRN1/CUL2/UBE4A/UBE2D1/ANAPC10/FBXW8/TRAF6/NEDD4L/ANAPC1/HERC3/RCHY1/UBE2O/UBE3B/ANAPC4/VHL/FZR1/PIAS3/RPS27A/SOCS1	9.26588571790938
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	91/2485	169/9376	2.03163596966414	AKT3/OPTN/SQSTM1/UVRAG/GABARAPL2/MAP1LC3A/CAMKK2/PPP2CB/BIRC6/VMP1/DAPK3/RAB7A/RB1CC1/MAP1LC3B/UBC/CALCOCO2/GABARAPL1/HIF1A/DAPK2/IGF1R/MAPK1/STX7/MAPK8/TBK1/KRAS/EIF2S1/MAPK3/RRAS2/PRKAA2/PPP2CA/ERN1/RAF1/DAPK1/WDR45B/BNIP3/ATG2B/RRAS/RAB8A/ATG101/ATG5/BECN1/HRAS/GABARAP/ATG3/IGBP1/VPS41/PIK3CA/HMGB1/ATG12/ATG4B/AMBRA1/MTMR3/PRKAA1/ATG10/PIK3C3/RPS6KB1/PIK3R3/ULK1/VPS39/BCL2/GORASP2/EIF2AK3/STX17/PIK3CB/SUPT20H/RRAGB/WDR41/DDIT4/AKT1/NRAS/WDR45/SNAP29/TRAF6/PIK3R4/ZFYVE1/NRBF2/EPG5/ATG14/RRAGC/MRAS/PLEKHM1/ATG9A/PRKCQ/DEPTOR/RAB33B/AKT1S1/RUBCN/GORASP1/VPS11/MTMR4/RPS27A	8.12677931683213
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	88/2485	174/9376	1.90820324244316	DNAJB1/HSPH1/DAD1/HSPA8/WFS1/BCAP29/HSP90AA1/PPP1R15A/ATF6/HSPA1A/ATXN3/UBXN4/HSPA1B/SEC62/KRTCAP2/SSR4/OS9/UBE2J1/DNAJA1/HSPA5/DNAJC3/NFE2L2/LMAN1/TXNDC5/SVIP/HSP90AB1/SEC61B/CAPN2/CRYAB/UBE2D2/VCP/TUSC3/BCAP31/RRBP1/HSPA6/UBE2G1/SEC31A/UBXN1/CUL1/PDIA6/DDIT3/BAG1/RAD23B/SEC24B/SEC63/UBE2D3/SEC61G/MAN1A1/TMEM258/STUB1/MAPK8/UBQLN1/EIF2S1/ERN1/EDEM3/UBE2G2/UFD1/MAN1A2/DNAJC1/SEC61A1/NPLOC4/ERO1B/PRKN/MAGT1/XBP1/RNF5/NGLY1/STT3B/UBE4B/SEC13/PRKCSH/UBXN2A/HSP90B1/BCL2/EIF2AK3/RNF185/DERL1/DERL2/UBE2D1/UBXN6/CAPN1/UGGT1/EDEM2/UBQLN4/HSPA4L/TRAF2/SEC61A2/HSPBP1	7.26146531953283
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	115/2485	250/9376	1.73559758551308	TGFBR2/ASAP1/PARD6G/HSPA8/CBLB/HLA-C/RAB11A/HLA-A/HLA-B/HSPA1A/EHD2/HSPA1B/PARD3/AP2B1/PDCD6IP/IQSEC1/GRK5/HLA-E/RAB11FIP1/VPS28/NEDD4/CHMP3/RAB31/SMAD2/EPS15/PRKCZ/EEA1/ARPC5L/AP2M1/ARFGEF1/CHMP4B/ASAP2/ARFGAP3/ARFGEF2/CHMP2A/RAB7A/ARRB1/PLD1/ARAP3/HLA-F/VPS37B/HSPA6/RABEP1/SMURF2/IGF1R/VPS36/AGAP1/ZFYVE9/RAB5A/CHMP4A/AP2A2/ARPC4/EHD4/SMURF1/SH3GL1/ARPC1A/TSG101/EPN2/ITCH/RAB11B/RAB11FIP5/EHD1/SMAP1/USP8/ARF5/SNX1/RAB22A/IGF2R/VPS35/GBF1/RAB8A/RUFY1/ARF3/SPART/PIP5K1A/RUFY2/GIT1/CYTH2/CHMP2B/RAB11FIP3/AGAP3/WIPF2/PML/HRAS/AP2A1/DNM3/EPN1/CBL/CHMP1B/MDM2/MVB12B/SMAD3/RAB4A/EPS15L1/ZFYVE27/LDLR/STAMBP/RAB35/STAM2/PIP5K1C/HGS/ARFGAP2/TRAF6/NEDD4L/VPS45/RNF41/WASHC2A/STAM/VPS26B/PRKCI/SNX12/RBSN/CHMP6/ARFGAP1/ACTR3B	7.07909559409763
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	57/2485	105/9376	2.04822075308997	OPTN/SQSTM1/GABARAPL2/TBC1D15/MAP1LC3A/RAB7A/VCP/ARIH1/MAP1LC3B/UBC/CALCOCO2/GABARAPL1/HIF1A/HUWE1/SMURF2/RAB5A/MAPK8/CSNK2A1/TBK1/KRAS/SMURF1/EIF2S1/CSNK2B/RRAS2/BNIP3/USP8/RABGEF1/RRAS/CSNK2A2/PHB2/OPA1/PRKN/BECN1/HRAS/GABARAP/RELA/AMBRA1/MTX2/ULK1/EIF2AK3/MITF/MFN1/BCL2L13/SIAH1/NRAS/CCZ1/CCZ1B/TFE3/MON1B/MRAS/MFN2/ATG9A/TOMM40/RHOT2/TFEB/TRAF2/RPS27A	6.48622220362325
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	109/2485	248/9376	1.65831115726618	RHOJ/S100A10/ANXA2/AKT3/TUBB6/ROCK2/HSP90AA1/TCF7L1/TUBA1A/TXN/FLNA/TUBB4B/DYNC1H1/DYNC1I2/AHNAK/DCTN2/KLC1/RALA/CASP4/NOD1/NCKAP1/MYL9/DYNLL1/BRK1/ARPC5L/HSP90AB1/RAB7A/KPNA4/DYNLT1/TNFRSF10B/MYL12A/DYNC1LI2/PIK3C2A/MYC/EXOC4/MYO6/DCTN3/NFKB1/ABI1/MAPK1/RIPK1/NFKBIA/RAB5A/WASF3/MAPK8/ARPC4/KPNA3/MAPK3/MAP2K4/GCC2/ARPC1A/DYNC1LI1/RAF1/MYL12B/CYCS/TCF7L2/RRAS/PLEKHM2/ARL8B/EXOC2/KPNA1/IKBKB/CYTH2/GAPDH/GSDMD/RAC1/DYNC1I1/RIPK2/HRAS/ACBD3/VPS41/PIK3CA/RELA/TAB2/ACTR1A/CASP7/MAPK14/DYNLT3/MAP2K3/PIK3C3/ELMO1/VPS39/HSP90B1/PIK3C2B/BCL2/DCTN1/PIK3CB/CASP3/DYNC2H1/PAK3/TUBA4A/IRAK4/FBXO22/AKT1/ACTR1B/MLKL/TRAF6/RILP/PLEKHM1/ACTG1/TAB3/DYNC2LI1/TRAF2/TCF7/VPS11/SNX33/FYCO1/ACTR3B/RPS3	6.30923857859667
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	52/2485	93/9376	2.10965578416737	ACTN1/TGFBR2/AFDN/ROCK2/TCF7L1/CTNND1/CTNNA1/ARHGAP29/NECTIN3/YES1/PTPRM/FYN/RAP1B/PARD3/TJP1/FER/MYL9/IQGAP1/MYL12A/NECTIN2/SORBS1/SMURF2/IGF1R/RASIP1/PTPRB/ROCK1/MAPK1/CREBBP/RAP1A/WASF3/FGFR1/CSNK2A1/SMURF1/MAPK3/PDCD10/VCL/CSNK2B/SMAD4/MYL12B/TCF7L2/PTPN1/CSNK2A2/INSR/CCM2/RAC1/BAIAP2/FARP2/SMAD3/WASF1/ACTG1/MET/TCF7	6.45792935906816
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	149/2485	368/9376	1.52767037004637	TUBB6/PPP3CA/OPTN/SQSTM1/TUBA1A/ATF6/COX7A1/ATP5F1E/TUBB4B/COX6A1/NDUFS7/MAP1LC3A/MCU/FUS/DCTN2/KLC1/PPP3CC/NDUFB8/NDUFC1/SEM1/PSMB3/PSMA7/PSMB2/COX7A2/ATXN2/HSPA5/NDUFB2/TPR/NDUFB11/HNRNPA3/NDUFB1/VCP/NUP153/PSMB7/COX5A/RB1CC1/MAP1LC3B/NDUFA11/NDUFB7/ATP5MC1/PSMB1/NDUFB10/SOD1/DCTN3/PSMB6/PSMA2/COX7A2L/DDIT3/NDUFS4/COX5B/PSMC5/RAB5A/NUP98/UBQLN1/PSMD1/PSMD13/PSMB5/TBK1/EIF2S1/PSMD7/COX6B1/NDUFA6/SETX/VDAC1/SRSF7/NDUFS8/ERN1/ANXA7/CYC1/CYCS/NDUFA10/ATG2B/PSMC3/UQCR11/CHCHD10/PSMD4/NDUFV1/RAB8A/ATG101/NXT1/PSMC4/PRKN/NDUFA4/XBP1/CHMP2B/COX6C/NDUFA8/PPP3R1/PPP3CB/SDHB/BECN1/RAC1/NDUFV3/PSMD9/NDUFA9/NRG3/TARDBP/NDUFS2/COX4I1/SPG11/PSMD14/ACTR1A/MAPK14/AMBRA1/SEC13/ATXN2L/MAP2K3/NUP58/BID/PIK3C3/ULK1/BCL2/EIF2AK3/DCTN1/SDHA/VAPB/SEH1L/CASP3/DERL1/TUBA4A/WDR41/ACTR1B/NUP107/APAF1/ALS2/CCS/PIK3R4/NRBF2/NUP43/ATG14/NUP205/DNAL1/DNAH14/NUP85/ACTG1/DAXX/NCBP1/TOMM40/SIGMAR1/UBQLN4/FIG4/NUP35/TRAF2/GRIA1/NUP188/GRIN2B/ITPR3/ANG/ERBB4	6.20126282966359
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	76/2485	157/9376	1.8264388881057	FOXO1/AKT3/TGFBR2/ETS1/HLA-C/HLA-A/PPP3CA/CDKN1A/HLA-B/SQSTM1/HIPK3/MCU/NFATC1/ZFP36L2/PPP3CC/HLA-E/SLC25A6/TGFB2/SMAD2/CAPN2/NFATC2/MYC/HLA-F/CCND1/NFKB1/MAPK1/FBXW11/HIPK1/TRPM7/KRAS/MAPK3/RRAS2/CCND3/VDAC1/RAF1/MAPKAPK2/RRAS/NFATC3/ATR/RBL2/PPP3R1/PPP3CB/PPP1CC/SERPINE1/HRAS/PIK3CA/RELA/GADD45A/MAPK14/HIPK2/MAP2K3/RAD9A/GADD45B/PIK3R3/BTRC/MDM2/MRE11/PIK3CB/SMAD3/AKT1/CAPN1/NBN/NRAS/RAD50/PPID/CALML4/E2F3/HUS1/MRAS/TRAF3IP2/GADD45G/LIN52/TGFB3/LIN54/ITPR3/CDK2	6.27084943308636
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	45/2485	77/9376	2.20502234184327	SHC1/AKT3/TGFBR2/CDKN1A/CTBP2/BRAF/TGFB2/POLK/MYC/PTPN11/CCND1/NFKB1/MAPK1/NFKBIA/BCR/KRAS/STAT5B/MAPK3/GAB2/HDAC1/SMAD4/RAF1/SOS2/IKBKB/HRAS/ABL1/PIK3CA/RELA/GADD45A/HDAC2/GADD45B/CBL/PIK3R3/SHC2/MDM2/PIK3CB/SMAD3/DDB2/AKT1/NRAS/E2F3/ARAF/STAT5A/GADD45G/TGFB3	6.37573191348853
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	109/2485	253/9376	1.62553820949412	ACTN1/FOXO1/AKT3/CAST/DOCK1/PLCE1/ROCK2/SQSTM1/PLCB4/CAPNS1/CTTN/FNBP1L/BCAR1/MAP1LC3A/TLN1/ITGA5/CASP4/PTK2/NOD1/PRKCE/MYL9/ARPC5L/GSK3B/PXN/UBE2N/HK1/CAPN2/CBX3/UBE2D2/MAP1LC3B/SEPTIN11/MYL12A/PLCG2/UBC/SEPTIN7/CALCOCO2/DIAPH1/ILK/CUL1/SEPTIN9/ROCK1/NFKB1/MAPK1/RIPK1/RBCK1/NFKBIA/UBE2D3/FBXW11/PLCB1/MAPK8/ARPC4/TBK1/MAPK3/VCL/VDAC1/ARPC1A/SEPTIN6/MYL12B/CYCS/BCL10/BNIP3/ITGB1/ATG5/IKBKB/CYTH2/BECN1/RAC1/MALT1/RIPK2/IRF3/TNIP1/PIK3CA/RELA/TAB2/ATG12/MAPK14/PIK3C3/RPS6KB1/ELMO1/PIK3R3/BTRC/MDM2/BCL2/PIK3CB/NFKBIB/RRAGB/PLCG1/UBE2D1/AKT1/CAPN1/GLMN/PPID/TRAF6/TIFA/PIK3R4/WASF1/ATG14/RRAGC/ACTG1/TAB3/PRKCQ/TRAF5/AKT1S1/TRAF2/ITPR3/U2AF1L4/ACTR3B/RPS27A/RNF31	6.05693587233016
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	183/2485	480/9376	1.4384708249497	APP/TUBB6/PPP3CA/OPTN/SQSTM1/PLCB4/CAMK2D/TUBA1A/ATF6/COX7A1/ATP5F1E/ATXN3/TUBB4B/BRAF/HIP1/COX6A1/NDUFS7/SNCA/PARK7/MAP1LC3A/MCU/FUS/DCTN2/KLC1/PPP3CC/NDUFB8/NDUFC1/SEM1/UBE2J1/SLC25A6/PSMB3/PSMA7/PSMB2/COX7A2/ATXN2/HSPA5/NDUFB2/GSK3B/NDUFB11/IFT57/CAPN2/NDUFB1/VCP/PSMB7/COX5A/RB1CC1/MAP1LC3B/NDUFA11/SNCAIP/UBC/NDUFB7/ATP5MC1/PSMB1/NDUFB10/SOD1/UBE2G1/DCTN3/PSMB6/PSMA2/COX7A2L/CSNK1E/DDIT3/NFKB1/MAPK1/NDUFS4/COX5B/PSMC5/RAB5A/ATP2A2/PLCB1/MAPK8/CSNK2A1/PSMD1/PSMD13/PSMB5/TBK1/KRAS/EIF2S1/MAPK3/PSMD7/COX6B1/NDUFA6/CSNK2B/UBE2L6/VDAC1/APC/FZD6/NDUFS8/ERN1/RAF1/CYC1/CYCS/NDUFA10/UBE2G2/ATG2B/PSMC3/UQCR11/PSMD4/NDUFV1/CSNK2A2/RAB8A/ATG101/LRP5/ATXN1/PSMC4/PRKN/NDUFA4/XBP1/CHMP2B/COX6C/NDUFA8/PPP3R1/PPP3CB/SDHB/BECN1/RAC1/NDUFV3/HRAS/PSMD9/NDUFA9/TARDBP/NDUFS2/COX4I1/SPG11/HSD17B10/PSEN1/PSMD14/RELA/ACTR1A/CASP7/MAPK14/AMBRA1/ATXN2L/MAP2K3/BID/PIK3C3/ULK1/BCL2/EIF2AK3/DCTN1/MFN1/NOX4/SDHA/VAPB/CASP3/DERL1/CSF1/TUBA4A/PLCG1/WDR41/CAMK2G/ACTR1B/CAPN1/NRAS/PPID/APAF1/CALML4/WNT2B/ALS2/CCS/PIK3R4/ZFYVE1/NRBF2/ATG14/DNAL1/DNAH14/WNT5A/ARAF/MFN2/DAXX/TOMM40/SIGMAR1/FIG4/WNT9A/TRAF2/PSEN2/GRIA1/GRIN2B/ITPR3/AXIN1/PPIF/CACNA1C/RPS27A	5.92204417767465
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	91/2485	205/9376	1.67486087255239	AKT3/JAK1/HLA-C/HLA-A/CDKN1A/HLA-B/STAT3/RELB/HLA-E/SEM1/HES1/NEDD4/POLK/SNW1/PLCG2/MYC/HLA-F/CCND1/NFKB1/RIPK1/TAPBP/NFKBIA/PSMC5/VIM/MAPK8/PSMD1/PSMD13/TBK1/LYN/PSMD7/MAP2K4/CCND3/HDAC1/CYCS/ISG15/PSMC3/PSMD4/EIF2AK2/SIN3A/TRAF3/PSMC4/IKBKB/HLA-DPB1/RAC1/NCOR2/IRF3/PIK3CA/HLA-DRB1/STAT1/PSMD14/RELA/TAB2/USP7/GADD45A/MAPK14/HDAC2/MAP2K3/GADD45B/BID/TNFAIP3/BCL2L11/PIK3R3/MDM2/BCL2/SAP30L/IRF9/HLA-DPA1/PIK3CB/NFKBIB/HLA-DQB1/CASP3/DDB2/OAS1/MAP3K14/IRAK4/NFKB2/AKT1/APAF1/TRAF6/E2F3/TAPBPL/SAP30/TAP2/TYK2/GADD45G/TRAF5/IRF7/NFKBIE/TRAF2/CDK2/HLA-DQA1	5.8666549088719
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	46/2485	83/9376	2.09108142832901	AUTS2/ASXL1/JARID2/SCMH1/CBX3/UBE2D2/SFMBT2/YAF2/MAX/UBE2D3/CREBBP/YY1/PHC2/CSNK2B/KDM2A/HDAC1/DCAF7/L3MBTL4/RYBP/PHC3/SUZ12/OGT/L3MBTL3/AEBP2/MBD5/USP7/FOXK1/HDAC2/USP16/MGA/TEX10/EZH1/PCGF3/UBE2D1/PHF1/RING1/SCML2/EZH2/USP45/HCFC1/FBRSL1/E2F6/BCOR/CBX4/CBX6/WDR5	5.9955075049878
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	46/2485	87/9376	1.99493975346331	AKT3/TGFBR2/CDKN1A/TCF7L1/RALGDS/BRAF/RALA/TGFB2/POLK/SMAD2/GSK3B/MYC/CCND1/MAPK1/MAPK8/KRAS/MAPK3/APC/SMAD4/RAF1/SOS2/CYCS/RALB/TCF7L2/RAC1/HRAS/PIK3CA/GADD45A/GADD45B/RPS6KB1/BCL2L11/PIK3R3/BCL2/PIK3CB/SMAD3/CASP3/DDB2/AKT1/NRAS/MLH1/BBC3/ARAF/GADD45G/TGFB3/AXIN1/TCF7	5.59860255975816
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	94/2485	224/9376	1.58332854268468	AKT3/TGFBR2/ETS1/CREB5/DLG1/JAK1/HLA-C/HLA-A/PPP3CA/CDKN1A/FDPS/HLA-B/ADCY4/ANAPC5/NFATC1/RELB/PPP3CC/HLA-E/TLN1/SLC25A6/TGFB2/MAP3K3/ANAPC16/SMAD2/CDC27/NFATC2/ETS2/MYC/HLA-F/CREB1/CCND1/NFKB1/MAPK1/MAP3K1/NFKBIA/CREBBP/MAPK8/KRAS/STAT5B/MAPK3/MAP2K4/ATF2/CCND3/VDAC1/SMAD4/GPS2/ELK4/XIAP/XPO1/FOSL1/BUB3/TBPL1/CDKN2C/KAT2B/NFATC3/IKBKB/ATR/HLA-DPB1/PPP3R1/LTBR/PPP3CB/HRAS/CDC26/CDC16/PIK3CA/TRRAP/HLA-DRB1/RELA/PIK3R3/ANAPC7/HLA-DPA1/PIK3CB/SMAD3/ADCY9/HLA-DQB1/MAP3K14/NFKB2/AKT1/ANAPC10/NRAS/IL15RA/IL15/POLB/ANAPC1/E2F3/ZFP36/KAT5/ADCY6/STAT5A/ANAPC4/MSX1/TGFB3/CDK2/HLA-DQA1	5.30624062778753
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	70/2485	158/9376	1.67159921554644	CDKN1A/YWHAH/YWHAB/ANAPC5/YWHAG/YWHAQ/STAG1/PPP2CB/PDS5A/TGFB2/ANAPC16/SMAD2/GSK3B/CDC27/NIPBL/PPP2R5C/MYC/CUL1/CCND1/ATRX/PDS5B/PPP2R5E/CREBBP/YWHAZ/CCND3/SMC3/HDAC1/PPP2CA/PPP2R1B/SMAD4/PPP2R5A/WAPL/HDAC8/BUB3/CDC14A/CDKN2C/ATR/RBL2/TFDP2/ABL1/CDC26/CDC16/CDC14B/GADD45A/HDAC2/ORC2/GADD45B/SMC1A/ANAPC7/MDM2/SMAD3/ANAPC10/ESCO1/ANAPC1/ORC4/WEE1/E2F3/ZBTB17/MCM3/ORC5/PPP2R5D/CDK7/MAD2L2/ANAPC4/PPP2R5B/GADD45G/MCM7/TGFB3/FZR1/CDK2	5.11243832160818
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	145/2485	388/9376	1.41002717334937	BACE2/APP/AKT3/TUBB6/PPP3CA/PLCB4/TUBA1A/ATF6/ADAM10/COX7A1/ATP5F1E/TUBB4B/BRAF/COX6A1/NDUFS7/SNCA/MCU/KLC1/PPP3CC/NDUFB8/NDUFC1/SEM1/SLC25A6/PSMB3/PSMA7/PSMB2/COX7A2/NDUFB2/SLC39A14/GSK3B/RTN4/NDUFB11/CAPN2/NDUFB1/PSMB7/COX5A/RB1CC1/NDUFA11/NDUFB7/ATP5MC1/PSMB1/NDUFB10/PSMB6/PSMA2/COX7A2L/CSNK1E/DDIT3/NFKB1/MAPK1/NDUFS4/COX5B/PSMC5/RTN3/ATP2A2/PLCB1/MAPK8/CSNK2A1/PSMD1/PSMD13/PSMB5/KRAS/EIF2S1/MAPK3/PSMD7/COX6B1/NDUFA6/CSNK2B/VDAC1/APC/FZD6/NDUFS8/ERN1/RAF1/ADAM17/CYC1/CYCS/NDUFA10/ATG2B/PSMC3/UQCR11/PSMD4/NDUFV1/CSNK2A2/EIF2AK2/ATG101/INSR/LRP5/PSMC4/PSENEN/NDUFA4/XBP1/IKBKB/COX6C/NDUFA8/PPP3R1/GAPDH/PPP3CB/SDHB/BECN1/NDUFV3/APH1B/HRAS/PSMD9/NDUFA9/PIK3CA/NDUFS2/COX4I1/HSD17B10/PSEN1/PSMD14/RELA/CASP7/AMBRA1/BID/PIK3C3/PIK3R3/ULK1/EIF2AK3/PIK3CB/NOX4/SDHA/CASP3/CSF1/TUBA4A/SLC39A10/AKT1/CAPN1/NRAS/PPID/APAF1/CALML4/WNT2B/PIK3R4/NRBF2/ATG14/WNT5A/ARAF/WNT9A/TRAF2/PSEN2/GRIN2B/ITPR3/AXIN1/PPIF/CACNA1C	4.95341460098967
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	24/2485	37/9376	2.4473761487846	CDKN1A/TCF7L1/BRAF/POLK/TPR/MYC/PPARG/CCND1/MAPK1/TPM3/KRAS/MAPK3/TFG/TCF7L2/CCDC6/HRAS/GADD45A/GADD45B/DDB2/NRAS/RXRA/RET/GADD45G/TCF7	5.29711980817537
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	56/2485	120/9376	1.76075117370892	SHC1/RPS6KA2/AKT3/CAMK2D/GAB1/BRAF/RAP1B/RPS6KA3/MAP3K3/GSK3B/PLCG2/PTPN11/NFKB1/MAPK1/MAP3K1/NFKBIA/RAP1A/ARHGDIA/KIDINS220/MAPK8/IRAK3/KRAS/MAPK3/RAF1/SOS2/MAPKAPK2/MAGED1/IRAK2/IKBKB/SH2B3/RAC1/FRS2/RIPK2/HRAS/ABL1/PIK3CA/PSEN1/RELA/MAPK14/PIK3R3/SHC2/BCL2/PIK3CB/NFKBIB/PLCG1/IRAK4/CAMK2G/AKT1/NRAS/CALML4/TRAF6/MAPK7/ZNF274/SH2B1/NFKBIE/PSEN2	5.03650524896648
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	40/2485	77/9376	1.96001985941624	AKT3/TGFBR2/JAK1/CDKN1A/RALGDS/STAT3/BRAF/RALA/TGFB2/POLK/SMAD2/RALBP1/PLD1/CCND1/NFKB1/MAPK1/MAPK8/KRAS/MAPK3/SMAD4/RAF1/RALB/IKBKB/RAC1/PIK3CA/STAT1/RELA/GADD45A/GADD45B/RPS6KB1/PIK3R3/PIK3CB/SMAD3/DDB2/AKT1/E2F3/ARAF/GADD45G/TGFB3/VEGFA	5.07943217542351
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	82/2485	196/9376	1.57851599392272	ANGPT2/GNG12/AKT3/CLEC2B/JAK1/HLA-C/HLA-A/PPP3CA/CDKN1A/TCF7L1/HLA-B/STAT3/MAP1LC3A/NFATC1/PPP3CC/HLA-E/GNB1/GSK3B/NFATC2/MAP1LC3B/PLCG2/UBC/MYC/HIF1A/HLA-F/CREB1/CCND1/NFKB1/MAPK1/NFKBIA/CREBBP/MAPK8/TBK1/KRAS/LYN/MAPK3/MAP2K4/GNB4/GNG5/RAF1/CYCS/MAPKAPK2/TCF7L2/EIF2AK2/GNG11/TRAF3/NFATC3/IKBKB/PPP3R1/PPP3CB/GNB5/BECN1/RAC1/HRAS/IRF3/ATG3/PIK3CA/STAT1/RELA/MAPK14/BID/PIK3C3/PIK3R3/IRF9/PIK3CB/CASP3/PLCG1/AKT1/NRAS/CALML4/ATG14/E2F3/ZFP36/TICAM1/TYK2/IRF7/CXCL1/TRAF2/VEGFA/ITPR3/TCF7/RPS27A	4.91507076527683
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	51/2485	108/9376	1.78171249720545	TNPO1/UPF3A/TPR/KPNB1/PNN/DDX39B/IPO11/NUP153/KPNA4/SUMO3/RBM8A/NUP98/UBE2I/KPNA3/UPF2/XPO1/EIF4A3/RNPS1/ACIN1/IPO5/NXT1/KPNA1/THOC1/CASC3/TNPO3/AHCTF1/SEC13/NUP58/XPO4/UPF3B/SENP2/NCBP2/SEH1L/RANGAP1/NMD3/XPO6/KPNA5/RANBP17/NUP107/TNPO2/NUP43/NUP205/UPF1/NUP85/XPO5/DDX19B/NCBP1/MAGOHB/SNUPN/NUP35/NUP188	4.90652063903121
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	22/2485	34/9376	2.4413776778317	RORA/PRKAG2/CRY1/CUL1/CREB1/CSNK1E/FBXW11/BHLHE40/PRKAA2/PER1/NFIL3/NR1D2/CLOCK/PRKAA1/PER3/BTRC/CSNK1D/CRY2/PRKAG1/NPAS2/RORB/NR1D1	5.05597629185149
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	67/2485	157/9376	1.61015007240898	AKT3/COX7A1/COX6A1/NDUFS7/PRKAG2/NDUFB8/NDUFC1/COX7A2/NDUFB2/GSK3B/NDUFB11/NDUFB1/COX5A/NDUFA11/NDUFB7/NDUFB10/PPARG/COX7A2L/DDIT3/NFKB1/MLXIP/NDUFS4/COX5B/MAPK8/EIF2S1/COX6B1/NDUFA6/PRKAA2/NDUFS8/ERN1/ITCH/CYC1/CYCS/NDUFA10/UQCR11/NDUFV1/INSR/NDUFA4/XBP1/IKBKB/COX6C/NDUFA8/SDHB/RAC1/NDUFV3/NDUFA9/PIK3CA/NDUFS2/COX4I1/RELA/CASP7/MAPK14/PRKAA1/BID/BCL2L11/PIK3R3/EIF2AK3/PIK3CB/SDHA/CASP3/PRKAG1/AKT1/MLX/RXRA/IL6R/PPARA/TRAF2	4.62969408958168
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	36/2485	70/9376	1.94041966082208	AKT3/ETS1/CDKN1A/PAK2/GAB1/BRAF/RAP1B/TGFB2/ELOC/PTPN11/HIF1A/MAPK1/CREBBP/RAP1A/KRAS/MAPK3/RAF1/SOS2/EGLN1/RAC1/HRAS/PIK3CA/EGLN3/PIK3R3/PIK3CB/PAK3/CUL2/FLCN/AKT1/NRAS/TFE3/ARAF/VHL/TGFB3/MET/VEGFA	4.7423860644104
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	21/2485	33/9376	2.40102432778489	VAMP3/SNAP23/VAMP2/VAMP5/STX7/STX2/STX8/STX5/STX11/VTI1A/STX3/VTI1B/GOSR1/STX4/STX16/STX17/STX6/SNAP29/USE1/GOSR2/BET1L	4.84135781722286
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	116/2485	308/9376	1.42101439807677	TUBB6/CREB5/POLR2L/PLCB4/TUBA1A/COX7A1/ATP5F1E/TUBB4B/HIP1/COX6A1/NDUFS7/AP2B1/DCTN2/KLC1/NDUFB8/NDUFC1/SEM1/SLC25A6/PSMB3/PSMA7/PSMB2/COX7A2/NDUFB2/AP2M1/NDUFB11/IFT57/NDUFB1/PSMB7/COX5A/SOD2/RB1CC1/NDUFA11/NDUFB7/ATP5MC1/POLR2I/PSMB1/NDUFB10/PPARG/SOD1/DCTN3/PSMB6/PSMA2/COX7A2L/CREB1/NDUFS4/COX5B/PSMC5/POLR2G/CREBBP/POLR2J3/AP2A2/PLCB1/MAPK8/PSMD1/PSMD13/POLR2H/PSMB5/POLR2A/PSMD7/COX6B1/NDUFA6/VDAC1/HDAC1/NDUFS8/ERN1/CYC1/CYCS/NDUFA10/ATG2B/PSMC3/UQCR11/PSMD4/NDUFV1/TBPL1/ATG101/SIN3A/PSMC4/POLR2J/NRF1/NDUFA4/RCOR1/POLR2B/COX6C/NDUFA8/SDHB/BECN1/NDUFV3/PSMD9/NDUFA9/AP2A1/NDUFS2/COX4I1/PSMD14/ACTR1A/AMBRA1/HDAC2/PIK3C3/ULK1/DCTN1/SDHA/TFAM/CASP3/TUBA4A/ACTR1B/POLR2C/APAF1/PIK3R4/NRBF2/ATG14/BBC3/DNAL1/DNAH14/TRAF2/GRIA1/GRIN2B/PPIF	4.51153426970734
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	82/2485	203/9376	1.52408440792539	RELN/LAMA4/FLT4/ACTN1/VAV3/SHC1/EMP1/AKT3/ITGAV/EMP2/TNXB/DOCK1/ROCK2/ITGA9/PAK2/ITGA1/FLNA/BRAF/FYN/VWF/PARVA/RAP1B/FLNB/BCAR1/LAMB2/TLN1/ITGA5/PTK2/MYL9/GSK3B/PXN/CAPN2/THBS1/MYL12A/DIAPH1/ITGA6/ILK/IGF1R/CCND1/ROCK1/MAPK1/RAP1A/MAPK8/MAPK3/PDGFA/VCL/PARVB/CCND3/RAF1/SOS2/MYL12B/LAMB1/XIAP/LAMC1/ITGB1/PIP5K1A/PPP1CC/RAC1/ZYX/HRAS/COL4A5/PIK3CA/ITGB4/PPP1R12B/PGF/PIK3R3/SHC2/BCL2/PPP1R12C/PIK3CB/ARHGAP35/PDGFD/PAK3/AKT1/PIP5K1C/TNC/ACTG1/ITGB3/MET/ITGA8/VEGFA/THBS3	4.53316232966727
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	33/2485	63/9376	1.97635335824471	KMT2E/SMYD2/SETD2/EHMT1/NSD3/KMT2A/KMT2C/PRDM2/SMYD3/PHYKPL/ASH1L/HADHA/ACAT1/CAMKMT/ALDH9A1/ALDH2/ECHS1/DLST/NSD1/ALDH3A2/EZH1/AASS/KMT2D/NSD2/SETDB1/EZH2/SETDB2/KMT2B/TMLHE/ACAT2/DOT1L/DHTKD1/EHMT2	4.66917560085155
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	62/2485	144/9376	1.62450257098144	RELN/RORA/AKT3/PLCB4/ATXN3/MCU/SEM1/SLC25A6/PSMB3/PSMA7/PSMB2/ATXN2/PSMB7/RB1CC1/PUM1/PSMB1/PSMB6/PSMA2/PSMC5/ATP2A2/PLCB1/MAPK8/PSMD1/PSMD13/PSMB5/PSMD7/VDAC1/ATXN10/PUM2/ERN1/CYCS/ATG2B/PSMC3/PSMD4/TBPL1/ATG101/OPA1/ATXN1/PSMC4/XBP1/BECN1/PSMD9/PIK3CA/PSMD14/AMBRA1/ATXN2L/PIK3C3/PIK3R3/ULK1/PIK3CB/AKT1/PIK3R4/NRBF2/ATG14/KAT5/NFYA/TRAF2/VLDLR/GRIA1/GRIN2B/ITPR3/PPIF	4.53497908595176
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	92/2485	235/9376	1.47710432809624	RPS6KA2/CREB5/PRKG1/COX7A1/ATP5F1E/ADCY4/PNPLA2/COX6A1/NDUFS7/PRKAG2/RPS6KA3/MGLL/NDUFB8/NDUFC1/COX7A2/NDUFB2/NDUFB11/SMARCC1/ARID1B/NDUFB1/SMARCA2/COX5A/NDUFA11/NDUFB7/ATP5MC1/NDUFB10/PPARG/COX7A2L/CREB1/NDUFS4/COX5B/SMARCE1/SLC25A29/FGFR1/ATP5ME/KRAS/COX20/COX6B1/ATF2/NDUFA6/COA3/PRKAA2/NDUFS8/NDUFAF3/CPT1A/ACSL3/SOS2/NDUFAF2/COX14/CYC1/NDUFA10/UQCR11/NDUFV1/SMARCA4/COA1/ACSL4/NDUFA4/COX6C/NDUFA8/SDHB/NDUFV3/FRS2/HRAS/GNAS/NDUFA9/KDM3B/NDUFS2/COX4I1/MAPK14/PRKAA1/ACSL5/MAP2K3/RPS6KB1/KDM3A/SMARCC2/COA4/SDHA/ADCY9/SMARCD1/PRKAG1/ZNF516/NPR1/KDM1A/NRAS/NDUFAF6/NDUFAF4/ACTG1/COX19/ADCY6/NDUFAF7/AKT1S1/SIRT6	4.44793203720061
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	75/2485	184/9376	1.53792319132184	SEMA3A/EFNA5/SEMA6A/SEMA3D/PARD6G/SSH1/ROCK2/PPP3CA/CAMK2D/PAK2/FYN/LIMK2/ABLIM1/PARD3/ARHGEF12/PPP3CC/NTN4/PTK2/MYL9/PRKCZ/GSK3B/PLXNA2/NCK1/NFATC2/EFNA1/RYK/MYL12A/PLCG2/PTPN11/DPYSL2/SRGAP2/ILK/SSH2/ABLIM3/ROCK1/MAPK1/RGS3/SRGAP1/UNC5B/KRAS/MAPK3/EPHB1/RAF1/MYL12B/RRAS/ITGB1/NFATC3/PPP3R1/PPP3CB/RAC1/CFL1/HRAS/ABL1/UNC5A/EPHB4/NCK2/CFL2/PIK3CA/PIK3R3/SRGAP3/NTN1/PIK3CB/PAK3/EPHA2/PLCG1/CAMK2G/NRAS/ABLIM2/RHOD/NEO1/WNT5A/SEMA4A/MET/ROBO3/SEMA4D	4.42518958661097
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	31/2485	59/9376	1.98244381543498	AKT3/CDKN1A/TCF7L1/CTNNA1/BRAF/POLK/GSK3B/MYC/ILK/CCND1/MAPK1/KRAS/MAPK3/APC/RAF1/SOS2/TCF7L2/HRAS/PIK3CA/GADD45A/GADD45B/PIK3R3/PIK3CB/DDB2/AKT1/NRAS/MLH1/ARAF/GADD45G/AXIN1/TCF7	4.5457274282916
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	47/2485	103/9376	1.72167763864742	SMG6/FUS/UPF3A/PPP2CB/PAPOLA/PNN/SMG1/DDX39B/PPP2R5C/CPSF6/WDR33/RBM8A/PPP2R5E/PPP2R3C/GSPT1/PPP2CA/PPP2R1B/UPF2/PPP2R2D/SSU72/PPP2R5A/EIF4A3/RNPS1/RNMT/SMG7/ACIN1/NXT1/PPP1CC/CASC3/TARDBP/PPP2R3A/PCF11/SYMPK/UPF3B/NCBP2/RNGTT/HBS1L/DAZAP1/SMG5/CSTF3/UPF1/PAPOLG/PPP2R5D/DDX19B/NCBP1/PPP2R5B/MAGOHB	4.42241445644617
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	42/2485	90/9376	1.76075117370892	AKT3/JAK1/PPP3CA/STAT3/NFATC1/PPP3CC/MAP3K3/NFATC2/PTPN11/HIF1A/NFKB1/MAPK1/NFKBIA/CSNK2A1/KRAS/MAPK3/CSNK2B/RAF1/CSNK2A2/NFATC3/IKBKB/PPP3R1/PPP3CB/HRAS/PIK3CA/STAT1/RELA/MAPK14/MAP2K3/RPS6KB1/PIK3R3/PIK3CB/NFKBIB/PLCG1/AKT1/NRAS/TRAF6/PRKCQ/CD274/TICAM1/NFKBIE/BATF3	4.35469011881448
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	111/2485	300/9376	1.39602414486922	ANGPT2/HSPB1/EFNA5/FLT4/RASGRP3/GNG12/RPS6KA2/AKT3/TGFBR2/HSPA8/PPP3CA/PAK2/HSPA1A/FLNA/BRAF/RAP1B/HSPA1B/RAPGEF2/STMN1/RPS6KA3/MAP4K4/NFATC1/RELB/PPP3CC/NF1/TGFB2/MAP3K3/PLA2G4C/EFNA1/ARRB1/MYC/TAOK1/HSPA6/IGF1R/DUSP5/DDIT3/NFKB1/MAPK1/MAX/NR4A1/MAP3K1/STK3/RAP1A/FGFR1/MAPK8/KRAS/MAPK3/PDGFA/MAP2K4/ATF2/RRAS2/DUSP6/RAF1/SOS2/ELK4/MAPKAPK2/RRAS/RASA2/INSR/NFATC3/GNA12/MAP3K2/DUSP16/IKBKB/PPP3R1/PPP3CB/PPM1B/RAC1/MAP3K20/HRAS/MAP4K2/MAP3K4/RASGRF2/JUND/RELA/TAB2/GADD45A/MAPK14/MAP2K3/GADD45B/PGF/MKNK2/PDGFD/PPP5C/MAPK8IP3/CASP3/EPHA2/CSF1/MAP3K14/IRAK4/NFKB2/AKT1/NRAS/TRAF6/RET/MAPK7/DUSP2/ARAF/MRAS/DAXX/CACNB2/GADD45G/DUSP8/ECSIT/TGFB3/DUSP10/MET/TRAF2/VEGFA/CACNA1C/ERBB4	4.18641963264621
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	53/2485	122/9376	1.63910677177821	VAV3/AKT3/DLG1/CBLB/PPP3CA/PAK2/FYN/NFATC1/PPP3CC/PPP2CB/GSK3B/NCK1/NFATC2/PPP2R5C/PTPN11/NFKB1/MAPK1/NFKBIA/PPP2R5E/MAPK8/PPP2R3C/KRAS/MAPK3/PPP2CA/PPP2R1B/PPP2R2D/RAF1/SOS2/PPP2R5A/BCL10/NFATC3/IKBKB/PPP3R1/PPP3CB/MALT1/HRAS/NCK2/PIK3CA/RELA/MAPK14/PPP2R3A/PIK3R3/PIK3CB/NFKBIB/PAK3/MAP3K14/PLCG1/AKT1/NRAS/PPP2R5D/PRKCQ/PPP2R5B/NFKBIE	4.26674115394524
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	47/2485	105/9376	1.68888377886366	AKT3/CBLB/PPP3CA/ARHGEF12/NFATC1/RELB/PPP3CC/NFATC2/PLCG2/PTPN11/IRF1/NFKB1/MAPK1/NFKBIA/MAPK8/KRAS/MAPK3/RRAS2/RAF1/BCL10/MAPKAPK2/RRAS/NFATC3/IKBKB/PPP3R1/PPP3CB/PLK3/MALT1/HRAS/PIK3CA/STAT1/RELA/MAPK14/PIK3R3/MDM2/IRF9/PIK3CB/BCL3/KSR1/MAP3K14/NFKB2/AKT1/NRAS/CALML4/MRAS/CLEC4M/ITPR3	4.26270253571085
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	69/2485	170/9376	1.53140963427625	MAGI1/CLDN5/ACTN1/MYH10/YBX3/DLG1/PARD6G/AFDN/ROCK2/TUBA1A/DLG2/PRKAG2/CTTN/PARD3/MYH9/HSPA4/RAPGEF2/RAB13/RDX/PPP2CB/TJP1/PRKCE/NEDD4/MYL9/PRKCZ/ARPC5L/MSN/F11R/RAB8B/ARHGAP17/MYL12A/MPDZ/CCND1/ROCK1/MAP3K1/MYL6B/RAP1A/MAPK8/ARPC4/ARPC1A/PRKAA2/PPP2CA/PPP2R1B/PPP2R2D/MYL12B/TJP2/RAB8A/ITGB1/MYH11/AMOTL1/RAC1/RAPGEF6/MYL6/PRKAA1/SYMPK/PATJ/WHAMM/PRKAG1/TUBA4A/SYNPO/NF2/NEDD4L/AMOT/ACTG1/TJAP1/PRKCI/LLGL2/ACTR3B/ARHGEF18	4.19880889865853
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	69/2485	170/9376	1.53140963427625	SHC1/AKT3/TGFBR2/CDKN1A/TCF7L1/GAB1/MGST2/BRAF/MGST3/GSTO1/TGFB2/POLK/SMAD2/NFE2L2/GSK3B/SMARCC1/ARID1B/SMARCA2/PLCG2/MYC/IGF1R/CCND1/MAPK1/SMARCE1/PBRM1/KRAS/MAPK3/ARID2/APC/FZD6/SMAD4/RAF1/SOS2/TCF7L2/TXNRD1/SMARCA4/LRP5/HRAS/PIK3CA/GADD45A/GADD45B/RPS6KB1/PIK3R3/SHC2/SMARCC2/PIK3CB/SMAD3/SMARCD1/DDB2/TXNRD2/PHF10/PLCG1/HMOX1/AKT1/NRAS/WNT2B/GSTM3/E2F3/WNT5A/ARAF/ACTG1/GADD45G/GSTT2B/TGFB3/WNT9A/MET/AXIN1/TCF7/MGST1	4.19880889865853
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	40/2485	86/9376	1.75490150203547	SHC1/AKT3/CBLB/CDKN1A/CAMK2D/PAK2/GAB1/BRAF/PTK2/ABL2/GSK3B/NCK1/PLCG2/MYC/MAPK1/MAPK8/KRAS/STAT5B/MAPK3/MAP2K4/RAF1/SOS2/HRAS/ABL1/NCK2/NRG3/PIK3CA/RPS6KB1/CBL/PIK3R3/SHC2/PIK3CB/PAK3/PLCG1/CAMK2G/AKT1/NRAS/ARAF/STAT5A/ERBB4	4.22317781802781
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	87/2485	227/9376	1.44605429936447	AKT3/COX7A1/ATP5F1E/MGST2/BRAF/COX6A1/NDUFS7/MGST3/GSTO1/NDUFB8/NDUFC1/EPHX1/PTK2/SLC25A6/COX7A2/NDUFB2/ABL2/PRKD2/NFE2L2/NDUFB11/NDUFB1/COX5A/SOD2/PLD1/NDUFA11/PTPN11/NDUFB7/ATP5MC1/HIF1A/NDUFB10/SOD1/COX7A2L/NFKB1/MAPK1/AKR1C3/NDUFS4/COX5B/NFKBIA/MAPK8/KRAS/AHR/MAPK3/MAP2K4/COX6B1/NDUFA6/VDAC1/AKR1A1/NDUFS8/RAF1/SOS2/CYC1/NDUFA10/UQCR11/NDUFV1/PTPN1/PRKD1/NDUFA4/IKBKB/COX6C/NDUFA8/PRKD3/SDHB/RAC1/NDUFV3/HRAS/ABL1/NDUFA9/PIK3CA/NDUFS2/COX4I1/RELA/MAPK14/PIK3R3/PIK3CB/NOX4/SDHA/MAP3K14/HMOX1/AKT1/NRAS/GSTM3/ARAF/GSTT2B/MET/VEGFA/MGST1/PPIF	4.08527742657529
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	120/2485	333/9376	1.35965341599144	RELN/MAGI1/LAMA4/FOXO1/AKT3/ITGAV/CREB5/DLG1/PARD6G/TNXB/JAK1/HLA-C/HLA-A/CDKN1A/TCF7L1/ITGA9/HLA-B/ITGA1/VWF/DLG2/PKM/PARD3/LAMB2/HLA-E/PPP2CB/ITGA5/HES4/PTK2/HES1/PRKCZ/GSK3B/PXN/THBS1/PPP2R5C/BCAP31/IRF1/HLA-F/ITGA6/CREB1/CCND1/NFKB1/MAPK1/PPP2R5E/CREBBP/PPP2R3C/TBK1/KRAS/MAPK3/CCND3/APC/HDAC1/FZD6/PPP2CA/PPP2R1B/PPP2R2D/RAF1/SOS2/PPP2R5A/LAMB1/ISG15/TCF7L2/EIF2AK2/TBPL1/UBE3A/LAMC1/ITGB1/TRAF3/ATP6V1D/UBR4/IKBKB/ATR/RBL2/HRAS/GNAS/NOTCH1/COL4A5/IRF3/PIK3CA/PSEN1/STAT1/RELA/ITGB4/NFX1/PPP2R3A/HDAC2/MAML2/RPS6KB1/PIK3R3/MDM2/PATJ/IRF9/PIK3CB/CASP3/AKT1/ATP6V1H/NRAS/WNT2B/MX1/RFNG/ATP6V0A2/MAML1/WNT5A/TCIRG1/TNC/PPP2R5D/ITGB3/PRKCI/TICAM1/PPP2R5B/TYK2/LLGL2/WNT9A/ITGA8/VEGFA/AXIN1/CDK2/TCF7/THBS3/MX2/TUBG2	4.01289457877828
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	56/2485	133/9376	1.58864767552685	FOXO1/AKT3/TGFBR2/CDKN1A/HOMER3/GABARAPL2/STAT3/BRAF/PRKAG2/TGFB2/SOD2/GABARAPL1/SGK3/IGF1R/CCND1/CSNK1E/MAPK1/CREBBP/MAPK8/KRAS/MAPK3/PRKAA2/SMAD4/RAF1/SOS2/BNIP3/INSR/HOMER1/DEPP1/IKBKB/RBL2/PLK3/HRAS/GABARAP/PIK3CA/USP7/ATG12/GADD45A/MAPK14/PRKAA1/GADD45B/BCL2L11/PIK3R3/MDM2/PIK3CB/SMAD3/G6PC3/PRKAG1/FBXO25/AKT1/NRAS/BCL6/ARAF/GADD45G/TGFB3/CDK2	4.10565532644976
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	42/2485	93/9376	1.70395274875057	LAMA4/AKT3/ITGAV/CDKN1A/LAMB2/PTK2/POLK/MYC/ITGA6/CCND1/NFKB1/MAX/NFKBIA/CYCS/LAMB1/XIAP/LAMC1/ITGB1/TRAF3/IKBKB/CKS1B/COL4A5/PIK3CA/RELA/GADD45A/GADD45B/PIK3R3/BCL2/PIK3CB/FHIT/CASP3/DDB2/AKT1/APAF1/RXRA/TRAF6/E2F3/ZBTB17/GADD45G/TRAF5/TRAF2/CDK2	4.09683542267494
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	53/2485	125/9376	1.59976820925553	AKT3/ROCK2/PLCB4/FYN/SPHK1/CERS6/PPP2CB/PRKCE/PRKCZ/PLD1/PPP2R5C/ROCK1/NFKB1/MAPK1/PPP2R5E/PLCB1/MAPK8/PPP2R3C/KRAS/MAPK3/GAB2/PPP2CA/PPP2R1B/PPP2R2D/RAF1/PPP2R5A/GNA12/ORMDL2/RAC1/SPTLC1/HRAS/PIK3CA/RELA/MAPK14/PPP2R3A/BID/CERS2/PIK3R3/BCL2/NSMAF/CERS5/PIK3CB/ABCC1/AKT1/NRAS/ACER2/CERS4/SGMS2/PPP2R5D/PPP2R5B/TRAF2/SMPD1/SGPL1	4.05370198896143
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	33/2485	68/9376	1.83103325837377	AKT3/TCF7L1/JUP/STAT3/BRAF/MYC/CCND1/NFKB1/MAPK1/KRAS/STAT5B/MAPK3/DUSP6/RAF1/SOS2/TCF7L2/ZBTB16/IKBKB/PML/HRAS/PIK3CA/RELA/RPS6KB1/PIK3R3/PPARD/PIK3CB/RUNX1T1/RARA/AKT1/NRAS/ARAF/STAT5A/TCF7	4.13002217647851
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	31/2485	63/9376	1.85657436683594	POLR2L/POLE4/RFC1/POLD4/POLR2I/RAD23B/POLR2G/POLR2J3/CUL4A/POLR2H/POLR2A/POLR2J/ERCC1/POLR2B/XPC/POLD2/CETN2/XPA/DDB2/GTF2H1/POLD3/POLR2C/RFC2/CDK7/POLR2M/ERCC6/POLE/GTF2H4/UVSSA/LIG1/ERCC2	4.09636132264197
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	50/2485	117/9376	1.61240949973344	BCL7C/CDK2AP1/GATAD2A/ZNHIT1/RSF1/BAZ1A/SMARCC1/BPTF/ARID1B/SMARCA2/INO80D/GATAD2B/BAZ2B/SMARCE1/YY1/PBRM1/ARID2/INO80C/MBD2/HDAC1/SMARCA1/MORF4L1/EPC1/SMARCA4/BAZ2A/BAZ1B/EP400/INO80/MTA3/TRRAP/HDAC2/MEAF6/SMARCC2/TFPT/SMARCD1/EPC2/BICRAL/PHF10/CHRAC1/SRCAP/ACTR6/RUVBL2/KAT5/ACTG1/ING3/NFRKB/MCRS1/VPS72/BCL7A/YEATS4	4.00276890608754
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	65/2485	163/9376	1.50458579699053	AKT3/TGFBR2/CREB5/JAK1/CDKN1A/STAT3/BRAF/HSPG2/YWHAB/NFATC1/YWHAQ/TGFB2/NFATC2/MYC/CREB1/NFKB1/MAPK1/MAP3K1/NFKBIA/CREBBP/MAPK8/TBK1/KRAS/STAT5B/MAPK3/MAP2K4/ATF2/YWHAZ/SMAD4/RAF1/SOS2/CYCS/DDX3X/TRAF3/NFATC3/IKBKB/HRAS/IRF3/PIK3CA/STAT1/RELA/TAB2/MAPK14/CASP10/MAP2K3/BID/PIK3R3/BCL2/PIK3CB/SMAD3/CASP3/DDB2/IRAK4/AKT1/NRAS/APAF1/TRAF6/E2F3/ARAF/STAT5A/TICAM1/TYK2/IRF7/TGFB3/CDK2	3.9024378774176
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	63/2485	157/9376	1.5140217098771	SMAD1/WWTR1/TGFBR2/DLG1/PARD6G/FRMD6/TCF7L1/CTNNA1/YWHAH/DLG2/PARD3/YWHAB/YWHAG/YWHAQ/LATS2/PPP2CB/TGFB2/BMP2/SMAD2/YAP1/PRKCZ/GSK3B/TEAD1/MYC/CCND1/CSNK1E/STK3/FBXW11/RASSF1/YWHAZ/CCND3/APC/FZD6/PPP2CA/PPP2R1B/SMAD4/PPP2R2D/TCF7L2/TEAD4/TP53BP2/CCN2/PPP1CC/SERPINE1/TEAD2/BTRC/CSNK1D/PATJ/SMAD3/LIMD1/NF2/WNT2B/AMOT/MOB1B/BBC3/WNT5A/ACTG1/PRKCI/LLGL2/TGFB3/WNT9A/WTIP/AXIN1/TCF7	3.9002917146907
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	82/2485	216/9376	1.43235710559654	VAV3/AKT3/HSPA8/ROCK2/PPP3CA/HSP90AA1/PLCB4/CAMK2D/ATF6/HSPD1/HSPA1A/STAT3/RAP1B/HSPA1B/HSPA4/NFATC1/PPP3CC/PTK2/HSPA5/ABCG1/NFE2L2/GSK3B/HSP90AB1/NFATC2/SOD2/TNFRSF10B/PPARG/HSPA6/POU2F1/DDIT3/NFKB1/MAPK1/NFKBIA/RAP1A/PLCB1/MAPK8/TBK1/KRAS/LYN/EIF2S1/MAPK3/MAP2K4/ERN1/CYCS/TRAF3/NFATC3/XBP1/IKBKB/PPP3R1/PPP3CB/RAC1/HRAS/IRF3/PIK3CA/RELA/TAB2/CASP7/MAPK14/MAP2K3/BID/PIK3R3/HSP90B1/BCL2/EIF2AK3/PIK3CB/CASP3/LDLR/PLCG1/IRAK4/CAMK2G/AKT1/NRAS/APAF1/CALML4/RXRA/TRAF6/TICAM1/IRF7/CXCL1/TRAF2/VLDLR/MIB2	3.86037459895021
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	44/2485	101/9376	1.64369982269857	FOXO1/AKT3/TGFBR2/PLCE1/PLCB4/STAT3/NFATC1/MMP2/TGFB2/PRKCE/SMAD2/PRKCZ/PLCG2/DIAPH1/CCND1/NFKB1/MAPK1/PLCB1/MAPK8/KRAS/STAT5B/MAPK3/THBD/SMAD4/SERPINE1/RAC1/HRAS/COL4A5/PIK3CA/STAT1/RELA/MAPK14/PIK3R3/BCL2/PIK3CB/SMAD3/NOX4/CASP3/PLCG1/AKT1/NRAS/STAT5A/TGFB3/VEGFA	3.90566353551944
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	100/2485	275/9376	1.37201390159137	TUBB6/CREB5/HSPA8/PPP3CA/TUBA1A/COX7A1/ATP5F1E/HSPA1A/TUBB4B/FYN/COX6A1/NDUFS7/HSPA1B/MCU/STIP1/KLC1/PPP3CC/NDUFB8/NDUFC1/SEM1/SLC25A6/PSMB3/PSMA7/PSMB2/COX7A2/HSPA5/NDUFB2/GSK3B/NDUFB11/NDUFB1/PSMB7/COX5A/NDUFA11/NDUFB7/ATP5MC1/PSMB1/NDUFB10/SOD1/HSPA6/PSMB6/PSMA2/COX7A2L/CREB1/DDIT3/MAPK1/NDUFS4/COX5B/PSMC5/MAPK8/CSNK2A1/PSMD1/PSMD13/PSMB5/EIF2S1/MAPK3/PSMD7/COX6B1/ATF2/NDUFA6/CSNK2B/VDAC1/NDUFS8/CYC1/CYCS/NDUFA10/PSMC3/UQCR11/PSMD4/NDUFV1/CSNK2A2/LAMC1/PSMC4/NDUFA4/COX6C/NDUFA8/PPP3R1/PPP3CB/SDHB/RAC1/NDUFV3/NOTCH1/PSMD9/NDUFA9/PIK3CA/NDUFS2/COX4I1/PSMD14/MAPK14/PIK3R3/EIF2AK3/PIK3CB/SDHA/CASP3/TUBA4A/NCAM1/APAF1/GRIN2B/ITPR3/PPIF/CACNA1C	3.76000713126378
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	30/2485	62/9376	1.82566365937561	FOXO1/AKT3/HSPA8/ADCY4/HSPA1A/PRKAG2/HSPA1B/CRYAB/SOD2/SOD1/HSPA6/IGF1R/KRAS/PRKAA2/HDAC1/INSR/ATG5/HRAS/PIK3CA/HDAC2/PRKAA1/RPS6KB1/PIK3R3/PIK3CB/ADCY9/PRKAG1/AKT1/NRAS/ADCY6/AKT1S1	3.91686504071202
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	24/2485	46/9376	1.96854168489196	SEM1/PSMB3/PSMA7/PSMB2/PSMB9/PSME4/PSME1/PSMB7/PSME2/PSMB1/PSMB6/PSMA2/PSMC5/PSMD1/PSMD13/PSMB5/PSMD7/PSMB8/PSMC3/PSMD4/PSMC4/PSMD9/PSMD14/PSME3	3.95424997659208
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	62/2485	156/9376	1.4995408347521	CLDN5/AKT3/JAK1/CDKN1A/YWHAH/STAT3/BRAF/YWHAB/YWHAG/YWHAQ/PPP2CB/GSK3B/PIAS1/MYC/CCND1/NFKB1/MAPK1/RIPK1/NFKBIA/TBK1/KRAS/EIF2S1/MAPK3/YWHAZ/PPP2CA/PPP2R1B/PPP2R2D/RAF1/SOS2/CYCS/CD81/EIF2AK2/TRAF3/IKBKB/HRAS/IRF3/PIK3CA/STAT1/RELA/BID/PIK3R3/IRF9/PIK3CB/CASP3/OAS1/LDLR/AKT1/NRAS/APAF1/RXRA/TRAF6/PSME3/MX1/E2F3/ARAF/TICAM1/TYK2/PPARA/IRF7/TRAF2/CDK2/MX2	3.77811822414659
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	88/2485	238/9376	1.39507295876097	ANGPT2/EFNA5/FLT4/RASGRP3/SHC1/GNG12/AKT3/ETS1/PLCE1/AFDN/RALGDS/PAK2/GAB1/RAP1B/RALGAPA2/RALA/RASAL2/GNB1/NF1/ABL2/PLA2G4C/RAPGEF5/EFNA1/RALBP1/PLD1/RALGAPA1/ETS2/PLCG2/PTPN11/IGF1R/NFKB1/MAPK1/REL/RAB5A/RAP1A/FGFR1/MAPK8/TBK1/KRAS/MAPK3/PDGFA/GAB2/RASSF1/GNB4/RGL2/RRAS2/GNG5/RAF1/SOS2/RALB/RRAS/GNG11/RASA2/SHOC2/INSR/EXOC2/RASA3/IKBKB/GNB5/RAC1/HRAS/ABL1/RASGRF2/PIK3CA/RELA/PGF/PIK3R3/SHC2/RALGAPB/PIK3CB/PDGFD/KSR1/PAK3/EPHA2/CSF1/PLCG1/AKT1/NRAS/BRAP/PLA2G6/CALML4/SYNGAP1/MRAS/PLA2G12A/RASAL3/MET/VEGFA/GRIN2B	3.70721621781646
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	77/2485	204/9376	1.42413697873516	VAV3/AKT3/ITGAV/PLCE1/ROCK2/CDKN1A/CAMK2D/GAB1/FLNA/STAT3/BRAF/CTTN/HSPG2/ARHGEF12/RDX/ITGA5/MMP2/PTK2/TGFB2/SMAD2/MSN/PXN/THBS1/IQGAP1/PLCG2/MYC/PTPN11/HIF1A/IGF1R/CCND1/DDX5/ROCK1/MAPK1/FGFR1/SDC4/KRAS/MAPK3/RRAS2/FZD6/RAF1/SOS2/RRAS/ITGB1/PPP1CC/RAC1/FRS2/HRAS/PIK3CA/PPP1R12B/MAPK14/CD63/RPS6KB1/CBL/PIK3R3/MDM2/PPP1R12C/PIK3CB/CASP3/PLCG1/CAMK2G/HOXD10/AKT1/NRAS/WNT2B/DROSHA/WNT5A/ARAF/MRAS/ACTG1/ITGB3/SLC9A1/WNT9A/MET/VEGFA/ITPR3/HPSE/ERBB4	3.67787452675816
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	97/2485	268/9376	1.36561458302051	TUBB6/CAMK2D/TUBA1A/ATF6/COX7A1/ATP5F1E/TXN/TUBB4B/COX6A1/NDUFS7/SNCA/PARK7/MCU/KLC1/NDUFB8/NDUFC1/SEM1/UBE2J1/SLC25A6/PSMB3/PSMA7/PSMB2/COX7A2/HSPA5/NDUFB2/NFE2L2/SLC39A14/NDUFB11/NDUFB1/PSMB7/COX5A/NDUFA11/SNCAIP/UBC/NDUFB7/ATP5MC1/PSMB1/NDUFB10/SOD1/UBE2G1/PSMB6/PSMA2/COX7A2L/DDIT3/NDUFS4/COX5B/PSMC5/MAPK8/PSMD1/PSMD13/PSMB5/EIF2S1/PSMD7/COX6B1/NDUFA6/UBE2L6/VDAC1/NDUFS8/ERN1/CYC1/CYCS/NDUFA10/UBE2G2/PSMC3/UQCR11/PSMD4/NDUFV1/PSMC4/PRKN/NDUFA4/XBP1/COX6C/NDUFA8/SDHB/NDUFV3/GNAS/PSMD9/NDUFA9/NDUFS2/COX4I1/PSMD14/EIF2AK3/MFN1/SDHA/CASP3/TUBA4A/PLCG1/SLC39A10/CAMK2G/APAF1/CALML4/MFN2/DAXX/ITPR3/PPIF/RPS27A/MAOB	3.64659141868785
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	46/2485	109/9376	1.59229136285604	RPS6KA2/FOXO1/AKT3/CREB5/STAT3/PRKAG2/RPS6KA3/PRKCE/PRKCZ/GSK3B/TBC1D4/PTPN11/CREB1/NFKB1/MLXIP/NFKBIA/MAPK8/PRKAA2/CPT1A/SLC27A3/PTPN1/INSR/IKBKB/OGT/PPP1CC/PIK3CA/RELA/PRKAA1/RPS6KB1/PIK3R3/PIK3CB/G6PC3/PRKAG1/AKT1/MLX/PTPA/PRKCQ/PYGB/SLC27A4/PPARA/TRIB3/ACACB/SLC27A1/GYS1/GFPT2/PPARGC1B	3.73496706699364
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	50/2485	122/9376	1.54632714318699	FOXO1/AKT3/ITGAV/PLCE1/PLCB4/NCOR1/GSK3B/TBC1D4/PLCG2/ATP1A1/MYC/HIF1A/CCND1/MAPK1/NCOA3/CREBBP/ATP2A2/PLCB1/KRAS/MED13/MAPK3/ATP1B3/HDAC1/RAF1/SIN3A/KAT2B/MED27/PFKL/NCOA1/HRAS/NOTCH1/MED13L/PIK3CA/STAT1/PFKP/HDAC2/PIK3R3/MDM2/PIK3CB/HDAC3/PLCG1/MED14/AKT1/NRAS/RXRA/ACTG1/ITGB3/MED17/SLC9A1/FXYD2	3.64733501237601
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	35/2485	78/9376	1.69302997472012	PLCE1/INPP4B/PLCB4/TPI1/PLCG2/PIK3C2A/ITPKC/PLCB1/MTMR2/ITPKB/MTMR6/PIP4K2A/IP6K2/PIP5K1A/CDIPT/PIK3CA/INPP1/MTMR3/PIK3C3/PIK3C2B/PIK3CB/IP6K1/PLCG1/SYNJ1/PIP5K1C/IMPA1/PI4K2B/INPP5K/SYNJ2/ITPK1/INPP5F/OCRL/FIG4/MTMR1/MTMR4	3.69072986564911
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	24/2485	48/9376	1.88651911468813	PCCA/HADHA/ACAT1/HADHB/ALDH9A1/ALDH2/ECHS1/BCAT1/HIBCH/HSD17B10/ACADM/AUH/ACADS/BCKDHB/ALDH3A2/OXCT1/ACAA1/MCCC2/MCCC1/BCKDHA/IVD/ACAT2/BCAT2/MCEE	3.69761903491852
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	37/2485	85/9376	1.64238134690496	GUK1/NT5C2/NT5E/PNP/AK2/NME2/NME1/NME3/NT5C3A/DGUOK/DCTPP1/ENTPD4/AK3/GMPS/CMPK1/NUDT16/AK1/NME7/UPP1/UCK2/NTPCR/NT5C3B/TK2/IMPDH1/GMPR2/DCTD/UCKL1/ADSL/CTPS2/ASMTL/RRM2B/ADA/RRM1/CTPS1/AK4/LACC1/ENTPD5	3.57255451234914
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	28/2485	60/9376	1.76075117370892	HSPB1/AKT3/PPP3CA/SPHK1/PPP3CC/PTK2/PXN/PLA2G4C/NFATC2/PLCG2/MAPK1/KRAS/MAPK3/RAF1/MAPKAPK2/PPP3R1/PPP3CB/RAC1/HRAS/PIK3CA/MAPK14/PIK3R3/SHC2/PIK3CB/PLCG1/AKT1/NRAS/VEGFA	3.54986000408271
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	41/2485	98/9376	1.57851599392272	PLCE1/INPP4B/PLCB4/DGKH/PLCG2/PIK3C2A/ITPKC/PLCB1/MTMR2/ITPKB/MTMR6/PIP4K2A/IP6K2/PIP5K1A/CDIPT/PIK3CA/INPP1/MTMR3/CDS2/PIK3C3/PIK3R3/PIK3C2B/DGKE/PIK3CB/IP6K1/PLCG1/SYNJ1/PIP5K1C/IMPA1/PI4K2B/CALML4/DGKD/SYNJ2/ITPK1/PIP4P1/INPP5F/OCRL/MTMR1/DGKA/ITPR3/MTMR4	3.457076052229
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	22/2485	44/9376	1.88651911468813	CREB5/RAB11A/DYNC1H1/DYNC1I2/DCTN2/DYNLL1/VAMP2/DYNC1LI2/CREB1/RAB5A/ARHGDIA/DYNC1LI1/RAB11B/DYNC1I1/GNAS/STX4/DCTN1/ADCY9/DYNC2H1/NSF/ADCY6/DYNC2LI1	3.53944189404175
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	17/2485	31/9376	2.06908548062569	SEC62/SEC11A/HSPA5/SEC61B/SEC63/SEC61G/SRP72/IMMP2L/SRP54/TMEM208/GET3/SEC61A1/GET1/SRPRB/SRP68/IMMP1L/SEC61A2	3.58023336240322
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	34/2485	78/9376	1.64465768972811	SHC1/DOCK1/CTNNA1/GAB1/CTTN/BCAR1/ITGA5/PTK2/ARPC5L/PXN/SEPTIN11/ILK/CD2AP/SEPTIN9/ARPC4/VCL/ARPC1A/SEPTIN6/ITGB1/RAC1/PIK3CA/DNM3/CBL/ELMO1/PIK3R3/SHC2/PIK3CB/ARHGAP10/WASF1/ACTG1/MAD2L2/MET/ACTR3B/SEPTIN1	3.43312335019965
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	60/2485	157/9376	1.44192543797819	ITGAV/DOCK1/ATP11A/CAMK2D/ADAM10/ATP11B/SPHK1/BCAR1/NFATC1/PTK2/ATP11C/CD47/RAB7A/RAB14/NFATC2/THBS1/PTPN11/ANO6/HIF1A/PPARG/CREB1/DUSP5/MAPK1/RAB5A/ATP2A2/ODC1/SIRPA/MAPK3/TGFBRAP1/MFGE8/CPT1A/ADAM17/MAPKAPK2/TMEM30A/NFATC3/DUSP16/RAC1/STAB2/VPS41/PROS1/CASP7/MAPK14/PBX1/ELMO1/PPARD/VPS39/SCARF1/CASP3/CAMK2G/PANX1/PLA2G6/RXRA/XKR6/DUSP2/ARG2/SLC16A1/ITGB3/DUSP8/VPS11/RAB17	3.35323993352247
NA	NA	hsa04517	IgSF CAM signaling	104/2485	299/9376	1.31236112326131	MAGI1/ACTN1/APP/NRP2/VAV3/FOXO1/EPB41L2/MYH10/AKT3/TRIO/TUBB6/PARD6G/AFDN/ROBO4/SPTBN1/TUBA1A/NECTIN3/PAK2/TUBB4B/FYN/RAP1B/PARD3/MYH9/BCAR1/RAPGEF2/RDX/ITGA5/PMP22/PTK2/TJP1/MYL9/DYNLL1/CASK/ARPC5L/MSN/F11R/GSK3B/PXN/PLXNA2/NCK1/IQGAP1/MYL12A/PLCG2/NECTIN2/SORBS1/PTPN11/SRGAP2/CD2AP/MPDZ/MAPK1/MYL6B/SRGAP1/RAP1A/FGFR1/MAPK8/ARPC4/ERC1/UNC5B/LYN/MAPK3/VCL/PPFIA1/ARPC1A/MYL12B/TJP2/PVR/ITGB1/MYH11/CABLES1/GIT1/RAC1/RAPGEF6/ABL1/UNC5A/NCK2/PIK3CA/MYL6/MAPK14/BAIAP2/MBP/PIK3R3/SRGAP3/NTN1/PIK3CB/KIRREL1/PAK3/TUBA4A/PLCG1/NCAM1/NLGN4X/AKT1/MAGI2/CXADR/MTSS2/TRAF6/EPB41L1/ACTG1/PRKCQ/CLEC4M/ITGB3/PRKCI/ROBO3/ACTR3B/MAP2	3.29631807685491
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	18/2485	34/9376	1.99749082731684	POLR2L/POLR1D/POLR2I/POLR2G/POLR2J3/POLR2H/POLR2A/POLR3GL/POLR2J/POLR2B/CRCP/POLR2C/POLR1C/POLR2M/POLR3D/POLR3A/POLR3B/POLR3F	3.49893719863904
Human Diseases	Infectious disease: viral	hsa05162	Measles	53/2485	136/9376	1.47037519233045	AKT3/HSPA8/CBLB/JAK1/HSPA1A/STAT3/HSPA1B/MSN/GSK3B/HSPA6/CCND1/NFKB1/NFKBIA/ADAR/MAPK8/CSNK2A1/TBK1/STAT5B/EIF2S1/CSNK2B/CCND3/CYCS/CSNK2A2/EIF2AK2/TRAF3/IKBKB/IRF3/PIK3CA/STAT1/RELA/TAB2/BID/TNFAIP3/PIK3R3/BCL2/IRF9/PIK3CB/NFKBIB/CASP3/OAS1/IRAK4/AKT1/APAF1/TRAF6/MX1/BBC3/RCHY1/CLEC4M/STAT5A/TYK2/IRF7/CDK2/MX2	3.3180703310869
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	77/2485	212/9376	1.37039596066968	MAGI1/ANGPT2/EFNA5/FLT4/RASGRP3/VAV3/AKT3/PARD6G/PLCE1/AFDN/PLCB4/CTNND1/RALGDS/ADCY4/BRAF/RAP1B/PARD3/BCAR1/RAPGEF2/RALA/TLN1/PRKCZ/PRKD2/THBS1/RAPGEF5/EFNA1/ARAP3/IGF1R/MAPK1/RAP1A/FGFR1/PLCB1/DOCK4/KRAS/MAPK3/PDGFA/RAF1/RALB/SIPA1L3/RRAS/INSR/PRKD1/ITGB1/SIPA1L1/F2R/PRKD3/RAC1/RAPGEF6/HRAS/GNAS/PIK3CA/MAPK14/MAP2K3/PGF/RAPGEF4/PIK3R3/FARP2/PIK3CB/PDGFD/SIPA1/ADCY9/EPHA2/CSF1/PLCG1/AKT1/MAGI2/NRAS/CALML4/F2RL3/MRAS/ACTG1/ADCY6/ITGB3/PRKCI/MET/VEGFA/GRIN2B	3.2756639552484
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	16/2485	29/9376	2.08167626448345	WWTR1/FRMD6/LATS2/YAP1/TEAD1/CSNK1E/STK3/RASSF1/TEAD4/TEAD2/DCHS1/LIMD1/FAT4/NF2/MOB1B/WTIP	3.50322383769575
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	32/2485	73/9376	1.65393456630192	AKT3/CDKN1A/STAT3/BRAF/POLK/PLCG2/CCND1/MAPK1/KRAS/STAT5B/MAPK3/RASSF1/RAF1/SOS2/HRAS/PIK3CA/GADD45A/GADD45B/PIK3R3/PIK3CB/FHIT/DDB2/PLCG1/AKT1/NRAS/RXRA/RET/E2F3/ARAF/STAT5A/GADD45G/MET	3.36815387146833
Human Diseases	Cancer: specific types	hsa05214	Glioma	33/2485	76/9376	1.63829291538706	SHC1/AKT3/CDKN1A/CAMK2D/BRAF/POLK/PLCG2/IGF1R/CCND1/MAPK1/KRAS/MAPK3/PDGFA/RAF1/SOS2/HRAS/PIK3CA/GADD45A/GADD45B/PIK3R3/SHC2/MDM2/CAMK1/PIK3CB/DDB2/PLCG1/CAMK2G/AKT1/NRAS/CALML4/E2F3/ARAF/GADD45G	3.35500410378231
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	83/2485	232/9376	1.34983695275099	ACTN1/VAV3/GNG12/MYH10/AKT3/ITGAV/DOCK1/SSH1/ROCK2/ITGA9/PAK2/ARHGEF7/ITGA1/BRAF/LIMK2/MYH9/BCAR1/ARHGEF12/RDX/ITGA5/PTK2/NCKAP1/MYL9/GSN/DIAPH2/BRK1/ARPC5L/MSN/PXN/IQGAP1/MYL12A/DIAPH1/ITGA6/SSH2/ROCK1/MAPK1/FGFR1/ARPC4/KRAS/MAPK3/PDGFA/VCL/RRAS2/ARPC1A/APC/RAF1/SOS2/MYL12B/PIP4K2A/RRAS/ITGB1/MYH11/F2R/GNA12/PIP5K1A/GIT1/PPP1CC/RAC1/CFL1/HRAS/CFL2/ABI2/PIK3CA/ITGB4/PPP1R12B/BAIAP2/PIK3R3/PPP1R12C/PIK3CB/ARHGAP35/PDGFD/PAK3/AKT1/PIP5K1C/NRAS/WASF1/ARAF/MRAS/ACTG1/ITGB3/SLC9A1/ITGA8/ACTR3B	3.24003181687394
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	53/2485	137/9376	1.459642526693	LMNA/AKT3/TUBA1A/MCL1/CAPN2/TNFRSF10B/CTSZ/CTSH/DDIT3/NFKB1/MAPK1/RIPK1/NFKBIA/MAPK8/KRAS/EIF2S1/MAPK3/ERN1/RAF1/CYCS/XIAP/IKBKB/HRAS/PARP4/PIK3CA/RELA/GADD45A/CASP7/CASP10/GADD45B/BID/BCL2L11/PIK3R3/BCL2/EIF2AK3/DFFA/PIK3CB/CASP3/CTSF/TUBA4A/MAP3K14/AKT1/CAPN1/NRAS/APAF1/BBC3/ACTG1/DAXX/GADD45G/CASP2/TRAF2/ITPR3/AIFM1	3.25443583347731
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	17/2485	32/9376	2.00442655935614	GABARAPL2/PPP2CB/GABARAPL1/PPP2CA/ATG2B/ATG101/ATG5/BECN1/GABARAP/ATG3/IGBP1/ATG12/ATG4B/ATG10/PIK3C3/PIK3R4/ATG9A	3.41770419904102
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	31/2485	71/9376	1.64738288888259	SHC1/AKT3/STAT3/GSK3B/SOCS2/IRF1/CCND1/NFKB1/MAPK1/MAPK8/KRAS/STAT5B/MAPK3/RAF1/SOS2/HRAS/TNFRSF11A/PIK3CA/STAT1/RELA/MAPK14/SOCS6/PIK3R3/SHC2/PIK3CB/AKT1/NRAS/SOCS4/SOCS5/STAT5A/SOCS1	3.28806134622594
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	77/2485	214/9376	1.35758852178491	GNG12/AKT3/HLA-C/HLA-A/PPP3CA/HLA-B/PAK2/LIMK2/NFATC1/PPP3CC/HLA-E/GNB1/PTK2/PXN/NFATC2/ELOC/PLCG2/HLA-F/CUL1/NFKB1/MAPK1/RIPK1/TAPBP/NFKBIA/CUL5/FBXW11/CUL4A/MAPK8/TBK1/KRAS/MAPK3/GNB4/GNG5/RAF1/CYCS/GNG11/NFATC3/IKBKB/ATR/PPP3R1/PPP3CB/GNB5/RAC1/CFL1/HRAS/IRF3/CFL2/PIK3CA/RELA/TAB2/MAPK14/MAP2K3/DCAF1/BID/RPS6KB1/PIK3R3/BTRC/BCL2/AP1G1/PIK3CB/AP1S1/CASP3/PAK3/PLCG1/IRAK4/AKT1/NRAS/TRIM5/CALML4/TRAF6/WEE1/TAPBPL/TAP2/TRAF5/AP1G2/TRAF2/ITPR3	3.17762777333075
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	53/2485	138/9376	1.44906540693436	VAV3/RPS6KA2/AKT3/DOCK1/ROCK2/ARHGEF28/ARHGEF7/SKAP2/BCAR1/ARHGEF12/RPS6KA3/NFATC1/ITGA5/PTK2/ARPC5L/GSK3B/PXN/NFATC2/ROCK1/NFKB1/MAPK1/NFKBIA/MAPK8/ARPC4/TBK1/MAPK3/MAP2K4/ARPC1A/ITGB1/NFATC3/PIP5K1A/IKBKB/RAC1/WIPF2/IRF3/PIK3CA/RELA/TAB2/MAPK14/BAIAP2/MAP2K3/ELMO1/PIK3R3/PIK3CB/PLCG1/IRAK4/AKT1/PIP5K1C/TRAF6/ACTG1/TICAM1/TRAF2/ACTR3B	3.19130178523713
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	74/2485	205/9376	1.36197477548216	ACTN1/CREB5/DLG1/JAK1/HLA-C/HLA-A/CDKN1A/HLA-B/YWHAH/STAT3/PKM/YWHAB/YWHAG/YWHAQ/HLA-E/GSN/SP100/PXN/SNW1/HLA-F/HDAC7/CREB1/CCND1/NFKB1/MAPK1/NFKBIA/CREBBP/REL/KRAS/LYN/STAT5B/MAPK3/ATF2/YWHAZ/CCND3/HDAC1/HDAC4/MAPKAPK2/DDX3X/HDAC8/EIF2AK2/RASA2/TBPL1/UBE3A/TRAF3/KAT2B/UBR4/RBL2/LTBR/RAC1/HRAS/IRF3/PIK3CA/RELA/USP7/HDAC2/PIK3R3/MDM2/IRF9/PIK3CB/HDAC3/CASP3/GTF2E2/GTF2H1/NFKB2/NRAS/POLB/STAT5A/TRAF5/IRF7/GTF2H4/TRAF2/CDK2/DNAJA3	3.14669464454005
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	33/2485	78/9376	1.59628540473611	HSPD1/BTG1/XRN2/ENO1/HSPA9/ZCCHC7/PAN3/DHX36/XRN1/LSM2/CNOT2/CNOT4/MTREX/TENT4A/PFKL/BTG3/NUDT16/PFKP/PNPT1/PATL1/TENT4B/CNOT9/TOB2/DIS3/CNOT10/CNOT8/CNOT6/EXOSC10/EXOSC1/EXOSC9/CNOT3/EXOSC4/DIS3L	3.17551683475019
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	20/2485	41/9376	1.84050645335427	CDKN1A/BRAF/MMP2/DAPK3/THBS1/MYC/DAPK2/CCND1/MAPK1/KRAS/MAPK3/RASSF1/RAF1/DAPK1/HRAS/MDM2/NRAS/E2F3/ARAF/VEGFA	3.23879551546968
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	80/2485	227/9376	1.32970510286388	GNG12/AKT3/ITGAV/CREB5/JAK1/HLA-C/ROCK2/HLA-A/PPP3CA/CDKN1A/HLA-B/PLCB4/ADCY4/STAT3/BCAR1/ARHGEF12/NFATC1/PPP3CC/HLA-E/GNB1/PTK2/GSK3B/PXN/NFATC2/MYC/HLA-F/CREB1/CCND1/ROCK1/NFKB1/MAPK1/RIPK1/TAPBP/NFKBIA/PLCB1/TBK1/KRAS/MAPK3/ATF2/GNB4/GNG5/RAF1/SOS2/CYCS/AKAP13/GNG11/NFATC3/GNA12/IKBKB/PPP3R1/PPP3CB/GNB5/RAC1/HRAS/GNAS/IRF3/PIK3CA/RELA/MAPK14/BID/RPS6KB1/PIK3R3/MDM2/ARHGEF11/PIK3CB/ADCY9/CASP3/AKT1/NRAS/CALML4/E2F3/TAPBPL/ADCY6/ITGB3/IL6R/TAP2/TRAF5/TRAF2/VEGFA/ITPR3	3.01967006276049
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	42/2485	106/9376	1.49497741163965	FOXO1/AKT3/ZEB1/CREB5/ERG/HSP90AA1/CDKN1A/TCF7L1/BRAF/GSK3B/HSP90AB1/IGF1R/CREB1/CCND1/NFKB1/MAPK1/NFKBIA/CREBBP/FGFR1/KRAS/MAPK3/PDGFA/RAF1/SOS2/TCF7L2/PLAT/IKBKB/HRAS/PIK3CA/RELA/PIK3R3/HSP90B1/MDM2/BCL2/PIK3CB/PDGFD/AKT1/NRAS/E2F3/ARAF/CDK2/TCF7	3.07755735651686
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	31/2485	73/9376	1.60224911110499	MAP1B/MDFIC/PDCD6IP/AFF4/BICD1/CHMP4B/NUP153/CPSF6/CREBBP/CHMP4A/SERINC5/TSG101/XPO1/SUPT4H1/CCNT2/KAT2B/PSIP1/ELL/TNPO3/NELFCD/PPIA/SUPT5H/CCNT1/BICD2/FEZ1/HGS/TRIM5/MX1/CHMP6/MAP1S/MX2	3.10194288494008
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	47/2485	122/9376	1.45354751459577	FOXO1/AKT3/CREB5/PRKAG2/CAMKK2/PPP2CB/RAB14/PPP2R5C/PPARG/IGF1R/CREB1/CCND1/CAB39/PPP2R5E/PPP2R3C/PRKAA2/PPP2CA/PPP2R1B/CPT1A/PPP2R2D/RAB11B/PPP2R5A/ACACA/TBC1D1/RAB8A/INSR/PFKFB3/PFKL/STRADA/ELAVL1/PIK3CA/PFKP/PPP2R3A/PRKAA1/RPS6KB1/PIK3R3/ULK1/PIK3CB/G6PC3/PRKAG1/AKT1/PPP2R5D/PPP2R5B/AKT1S1/ACACB/GYS1/HMGCR	3.02792887080677
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	43/2485	110/9376	1.47491494421072	ANGPT2/AKT3/TIMP1/CDKN1A/CAMK2D/STAT3/HK1/ENO1/ELOC/PLCG2/HIF1A/IGF1R/NFKB1/MAPK1/LDHA/CREBBP/MAPK3/EGLN1/INSR/PFKFB3/GAPDH/LTBR/SERPINE1/PFKL/PIK3CA/RELA/PFKP/EIF4E2/EGLN3/RPS6KB1/PIK3R3/BCL2/PIK3CB/MKNK2/PDHA1/CUL2/PLCG1/CAMK2G/HMOX1/AKT1/IL6R/VHL/VEGFA	3.00866435112616
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	65/2485	180/9376	1.36248602727476	AKT3/JAK1/HLA-C/HLA-A/HLA-B/HLA-E/SRSF4/ITGA5/SP100/SRSF2/NECTIN2/PTPN11/HLA-F/POU2F1/NFKB1/TAPBP/NFKBIA/TBK1/EIF2S1/TNFRSF14/SRSF7/CYCS/EIF2AK2/TRAF3/IKBKB/HLA-DPB1/ZC3HAV1/PPP1CC/PML/IRF3/PIK3CA/HLA-DRB1/SRPK1/STAT1/RELA/TAB2/PILRB/BID/PIK3R3/BCL2/IRF9/HLA-DPA1/PIK3CB/HLA-DQB1/CASP3/OAS1/IRAK4/EIF2B2/AKT1/EIF2B1/APAF1/HCFC2/TRAF6/HCFC1/TAPBPL/DAXX/ITGB3/EIF2B5/TICAM1/TAP2/TYK2/TRAF5/IRF7/TRAF2/HLA-DQA1	2.94873504660421
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	27/2485	62/9376	1.64309729343805	CTBP2/NUMB/TLE1/HES1/SPEN/SNW1/CREBBP/DTX1/HDAC1/ITCH/ADAM17/KAT2B/ATXN1/PSENEN/APH1B/NCOR2/NOTCH1/PSEN1/HDAC2/MAML2/DLL4/DTX3L/DTX4/RFNG/MAML1/PSEN2/NUMBL	3.05078863268476
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	39/2485	98/9376	1.50151521373137	VAV3/AKT3/ASAP1/MARCKSL1/DOCK1/SPHK1/LIMK2/PLPP1/PRKCE/GSN/ARPC5L/ASAP2/PLA2G4C/PLD1/PLCG2/MAPK1/WASF3/ARPC4/LYN/MAPK3/GAB2/MARCKS/ARPC1A/RAF1/PIP5K1A/RAC1/CFL1/CFL2/PIK3CA/RPS6KB1/PIK3R3/PIK3CB/PLCG1/AKT1/PIP5K1C/PLA2G6/WASF1/PLPP2/ACTR3B	2.99693742858011
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	33/2485	80/9376	1.55637826961771	SHC1/AKT3/JAK1/GAB1/STAT3/BRAF/NF1/GSK3B/PLCG2/IGF1R/MAPK1/KRAS/MAPK3/PDGFA/RAF1/SOS2/HRAS/PIK3CA/EIF4E2/RPS6KB1/BCL2L11/PIK3R3/SHC2/BCL2/PIK3CB/PDGFD/PLCG1/AKT1/NRAS/ARAF/IL6R/MET/VEGFA	3.00106087686087
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	67/2485	187/9376	1.35183722656796	JAK1/HSP90AA1/PLCB4/TXN/GABARAPL2/ERBIN/MAP1LC3A/MCU/CASP4/NOD1/HSP90AB1/MAP1LC3B/GABARAPL1/NFKB1/MAPK1/RIPK1/RBCK1/NFKBIA/DNM1L/SUGT1/PLCB1/MAPK8/TRPM7/TBK1/MAPK3/VDAC1/TP53BP1/XIAP/TRAF3/ATG5/IKBKB/GSDMD/ANTXR2/RIPK2/GABARAP/IRF3/TRIP6/STAT1/RELA/TAB2/ATG12/GBP2/MAPK14/TNFAIP3/BCL2/IRF9/MFN1/NFKBIB/CARD6/GBP1/OAS1/IRAK4/PANX1/TRAF6/MFN2/TAB3/TICAM1/TYK2/TRAF5/IRF7/CXCL1/DHX33/TRAF2/ITPR3/BRCC3/RNF31/GBP3	2.91834193587812
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	86/2485	250/9376	1.29792515090543	NCOA7/OSBPL1A/AP2B1/OSBPL3/LAPTM5/VPS13C/AP2M1/RAB7A/GUSB/VPS13A/CTSZ/CTSH/SCARB2/BORCS7/AP2A2/OSBP/DTNBP1/AP3S1/IGF2R/VPS35/LAPTM4A/OSBPL6/ARL8B/ATP6V1D/IDS/ENTPD4/CTSA/NPC1/ABCA5/CLN8/OSBPL5/HGSNAT/AP3B1/VPS41/AP2A1/SPG11/CD63/WDR7/AP5Z1/VPS39/GNPTG/STX17/AP1G1/MITF/GGA1/AP1S1/LAPTM4B/TPCN1/CTSF/GLA/RRAGB/NAGLU/DNASE2/ATP6V1H/OSTM1/AP4S1/SNAP29/OSBPL2/SLC38A9/AP3M2/GGA2/MEAK7/ATP6V0A2/TFE3/AP4E1/RRAGC/TCIRG1/BLOC1S2/PLEKHM1/SNAPIN/VPS26B/BORCS8/DEPTOR/HYAL1/TFEB/SLC15A4/ROGDI/FIG4/AGA/GGA3/AKT1S1/AP1G2/AP4M1/VPS11/SMPD1/BORCS5	2.86711194365118
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	55/2485	149/9376	1.3927322323201	SHC1/AKT3/PLCB4/RALGDS/ADCY4/GAB1/FYN/SPHK1/RALA/DGKH/PLPP1/PLA2G4C/PLD1/AGPAT4/PLCG2/PTPN11/MAPK1/PLCB1/KRAS/MAPK3/PDGFA/GAB2/AGPAT5/RRAS2/RAF1/SOS2/RALB/RRAS/INSR/F2R/GNA12/PIP5K1A/AGPAT3/CYTH2/HRAS/GNAS/PIK3CA/DNM3/RAPGEF4/PIK3R3/SHC2/DGKE/PIK3CB/PDGFD/ADCY9/PLCG1/AKT1/PIP5K1C/NRAS/DGKD/MRAS/ADCY6/AGPAT2/PLPP2/DGKA	2.90179768454099
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	39/2485	99/9376	1.48634839339065	AKT3/RALGDS/DGKH/PLPP1/PLA2G4C/PLD1/HIF1A/MAPK1/WASF3/MAPK8/KRAS/MAPK3/PDGFA/RAF1/SOS2/GPCPD1/LYPLA1/PIP5K1A/RAC1/HRAS/PIK3CA/RPS6KB1/CHKA/PIK3R3/DGKE/PIK3CB/PDGFD/CHPT1/PLCG1/AKT1/CHKB/PIP5K1C/NRAS/DGKD/WASF1/PLPP2/SLC44A3/DGKA/SLC22A4	2.92125194351435
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	36/2485	90/9376	1.5092152917505	FOXO1/AKT3/CREB5/ADCY4/PRKAG2/CAMKK2/EHMT1/SOD2/RB1CC1/SESN3/PPARG/IGF1R/CREB1/NFKB1/KRAS/ATF2/PRKAA2/ATG101/INSR/ATG5/HRAS/PIK3CA/RELA/EIF4E2/PRKAA1/RPS6KB1/PIK3R3/ULK1/PIK3CB/ADCY9/PRKAG1/AKT1/NRAS/ADCY6/AKT1S1/EHMT2	2.91484900184144
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	31/2485	75/9376	1.55952246814219	CDKN1A/THBS1/TNFRSF10B/SESN3/SIVA1/PPP1R13L/CCND1/CCND3/CYCS/COP1/ATR/TP53I3/SERPINE1/MDM4/GADD45A/EI24/CD82/GADD45B/BID/MDM2/BCL2/CASP3/SIAH1/DDB2/APAF1/BBC3/PERP/RCHY1/RRM2B/GADD45G/CDK2	2.92140016862142
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	43/2485	112/9376	1.44857717734981	LAMA4/AKT3/HSPA8/JAK1/HSPA1A/STAT3/HSPA1B/LAMB2/TGFB2/ITGA6/HSPA6/NFKB1/MAPK1/NFKBIA/MAPK8/MAPK3/CYCS/LAMB1/XIAP/LAMC1/ITGB1/IKBKB/HLA-DPB1/HLA-DRB1/STAT1/RELA/TAB2/MAPK14/MAP2K3/BCL2/HLA-DPA1/NFKBIB/HLA-DQB1/CASP3/LDLR/IRAK4/AKT1/TRAF6/TYK2/TGFB3/PPIF/SOCS1/HLA-DQA1	2.86783804442733
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	42/2485	109/9376	1.45383124434681	RORA/TGFBR2/JAK1/PPP3CA/HSP90AA1/STAT3/NFATC1/PPP3CC/SMAD2/HSP90AB1/NFATC2/HIF1A/NFKB1/MAPK1/NFKBIA/MAPK8/AHR/STAT5B/MAPK3/SMAD4/NFATC3/IKBKB/HLA-DPB1/PPP3R1/PPP3CB/HLA-DRB1/STAT1/RELA/MAPK14/HLA-DPA1/SMAD3/NFKBIB/HLA-DQB1/PLCG1/RARA/RXRA/PRKCQ/STAT5A/IL6R/TYK2/NFKBIE/HLA-DQA1	2.86184276507862
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	51/2485	138/9376	1.39438369346514	RPS6KA2/PPP3CA/CAMK2D/ADCY4/YWHAH/RPS6KA3/YWHAB/ANAPC5/YWHAG/YWHAQ/PPP3CC/PPP2CB/ANAPC16/CDC27/PPP2R5C/CUL1/IGF1R/SLK/MAPK1/PPP2R5E/FBXW11/MAPK3/YWHAZ/SMC3/PPP2CA/PPP2R1B/PPP2R5A/PPP3R1/PPP3CB/PPP1CC/CDC26/CDC16/MAPK14/CPEB3/SMC1A/BTRC/ANAPC7/CPEB2/ADCY9/CAMK2G/ANAPC10/CALML4/ANAPC1/PPP2R5D/ADCY6/MAD2L2/ANAPC4/PPP2R5B/ITPR3/CDK2/SPDYE2	2.80270393931207
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	70/2485	200/9376	1.32056338028169	MYO1D/CLDN5/MYH10/TUBB6/ROCK2/TUBA1A/PAK2/TUBB4B/FYN/CTTN/MYH9/ARHGEF12/CASP4/TJP1/NCKAP1/BRK1/ARPC5L/MYO5C/NCK1/TNFRSF10B/PTPN11/MYO6/MYO1B/ROCK1/NFKB1/ABI1/MAPK1/RIPK1/SEC24B/NFKBIA/MYO1E/WASF3/MAPK8/ARPC4/TMED10/MAPK3/NCL/ARPC1A/CYCS/ITGB1/MYH11/F2R/GNA12/TMBIM6/IKBKB/CYTH2/GAPDH/RAC1/WIPF2/ABL1/NCK2/RELA/TAB2/CASP7/MAPK14/BAIAP2/ARHGEF11/NFKBIB/CASP3/PAK3/TUBA4A/IRAK4/TRAF6/WASF1/ACTG1/TAB3/ABCF2/TRAF2/ACTR3B/RPS3	2.75175594976029
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	40/2485	104/9376	1.4511685497601	DGKH/PLPP1/LPIN2/PLA2G4C/PLD1/AGPAT4/LPGAT1/AGPAT5/ETNK1/GPCPD1/LYPLA1/AGPAT3/CDIPT/SELENOI/GNPAT/LPCAT3/CDS2/CHKA/DGKE/LCLAT1/CHPT1/PTDSS1/GPAT4/MBOAT1/CHKB/PISD/PLA2G6/CRLS1/MBOAT2/GPAT3/DGKD/GDPD5/SGMS2/PLA2G12A/PEMT/PTDSS2/PLPP5/AGPAT2/PLPP2/DGKA	2.77828302861511
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	20/2485	44/9376	1.71501737698921	POLE4/RFC1/POLD4/MPG/PARP4/HMGB1/TDG/APEX1/APTX/POLD2/MBD4/PNKP/POLD3/RFC2/POLB/NEIL1/PARG/POLE/POLG/LIG1	2.85471843432699
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	40/2485	105/9376	1.43734789690524	CCL21/RELB/PLCG2/PPP1R13L/NFKB1/RIPK1/NFKBIA/CSNK2A1/UBE2I/ERC1/LYN/CSNK2B/XIAP/BCL10/CSNK2A2/TRAF3/CARD10/IKBKB/LTBR/MALT1/TNFRSF11A/RELA/TAB2/GADD45A/GADD45B/TNFAIP3/BCL2/MAP3K14/PLCG1/IRAK4/NFKB2/TRAF6/TRIM25/TAB3/PRKCQ/TICAM1/GADD45G/TRAF5/CXCL1/TRAF2	2.70623876817218
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	70/2485	205/9376	1.28835451734799	AKT3/TGFBR2/PLCB4/CAMK2D/COX7A1/ATP5F1E/COX6A1/NDUFS7/NDUFB8/NDUFC1/MMP2/SLC25A6/TGFB2/COX7A2/NDUFB2/SMAD2/PRKCZ/GSK3B/NDUFB11/TBC1D4/NDUFB1/COX5A/NDUFA11/NDUFB7/ATP5MC1/NDUFB10/COX7A2L/NFKB1/NDUFS4/COX5B/ATP2A2/PLCB1/MAPK8/COX6B1/NDUFA6/VDAC1/NDUFS8/CYC1/NDUFA10/UQCR11/NDUFV1/INSR/NDUFA4/MPC1/COX6C/NDUFA8/GAPDH/PPP1CC/SDHB/RAC1/NDUFV3/NDUFA9/PIK3CA/NDUFS2/COX4I1/RELA/MAPK14/PIK3R3/PIK3CB/SMAD3/SDHA/PDHA1/CAMK2G/AKT1/PTPA/PPARA/TGFB3/GYS1/PPIF/GFPT2	2.50670399410903
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	27/2485	67/9376	1.52047809243521	RPS6KA2/PPP3CA/PLCB4/CAMK2D/BRAF/RAP1B/RPS6KA3/PPP3CC/MAPK1/CREBBP/RAP1A/PLCB1/KRAS/MAPK3/RAF1/PPP3R1/PPP3CB/PPP1CC/HRAS/CAMK2G/NRAS/CALML4/ARAF/GRIA1/GRIN2B/ITPR3/CACNA1C	2.56741485810043
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	50/2485	140/9376	1.34751365334866	GNG12/AKT3/PLCB4/ADCY4/PRKAG2/SPHK1/MAP1LC3A/GNB1/PRKCE/SMAD2/MAP1LC3B/CCND1/ACTA2/MAPK1/PLCB1/KRAS/MAPK3/GNB4/RRAS2/PRKAA2/SMAD4/GNG5/HDAC4/RAF1/RRAS/GNG11/PLAT/NRF1/MEF2A/CCN2/SERPINE1/GNB5/BECN1/HRAS/PRKAA1/PIK3C3/RPS6KB1/MEF2D/SMAD3/TFAM/ADCY9/PRKAG1/AKT1/NRAS/CALML4/PIK3R4/MRAS/ADCY6/SLC9A1/ITPR3	2.48772080150742
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	24/2485	59/9376	1.53479521194966	NT5C2/NT5E/NME2/NME1/NME3/NT5C3A/DCTPP1/ENTPD4/CMPK1/DHODH/NME7/UPP1/UCK2/NT5C3B/TK2/DCTD/UCKL1/CDADC1/CTPS2/ASMTL/RRM2B/RRM1/CTPS1/ENTPD5	2.47447561406069
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	23/2485	56/9376	1.54964070135096	GSK3B/ARRB1/CUL3/CUL1/SMURF2/CCND1/CSNK1E/SPOP/FBXW11/SMURF1/CSNK1G3/CSNK1G1/MOSMO/BTRC/BCL2/CSNK1D/MGRN1/EVC2/KIF3A/GPR161/HHAT/IQCE/MEGF8	2.47726605777569
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	115/2485	362/9376	1.19861711706704	RELN/MAGI1/ANGPT2/LAMA4/EFNA5/FLT4/GNG12/AKT3/ITGAV/CREB5/TNXB/JAK1/HSP90AA1/CDKN1A/ITGA9/IL7/ITGA1/YWHAH/CDC37/VWF/YWHAB/YWHAG/YWHAQ/MCL1/LAMB2/PPP2CB/GNB1/ITGA5/PTK2/GSK3B/HSP90AB1/THBS1/EFNA1/PPP2R5C/MYC/SGK3/ITGA6/IGF1R/CREB1/CCND1/NFKB1/MAPK1/NR4A1/PPP2R5E/FGFR1/PPP2R3C/KRAS/MAPK3/PDGFA/ATF2/YWHAZ/GNB4/CCND3/PRKAA2/PPP2CA/PPP2R1B/GNG5/PPP2R2D/RAF1/SOS2/PPP2R5A/LAMB1/GNG11/INSR/LAMC1/ITGB1/F2R/IKBKB/RBL2/GHR/GNB5/RAC1/HRAS/COL4A5/PIK3CA/RELA/ITGB4/PPP2R3A/EIF4E2/PRKAA1/PGF/RPS6KB1/BCL2L11/PIK3R3/HSP90B1/MDM2/BCL2/PIK3CB/PDGFD/G6PC3/PHLPP1/EPHA2/CSF1/DDIT4/AKT1/MAGI2/NRAS/THEM4/RXRA/PHLPP2/RET/PKN3/TNC/PPP2R5D/CSF3/ITGB3/IL6R/PPP2R5B/MET/ITGA8/VEGFA/GYS1/CDK2/THBS3/ERBB4	2.3143012609719
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	40/2485	110/9376	1.37201390159137	SMAD1/TGFBR2/THSD4/PPP2CB/NCOR1/TGFB2/BMP2/SMAD2/NBL1/THBS1/MYC/CUL1/SMURF2/ROCK1/MAPK1/ZFYVE9/CREBBP/SKIL/SMURF1/MAPK3/HDAC1/PPP2CA/PPP2R1B/SMAD4/SMAD9/SIN3A/SKI/HDAC2/RPS6KB1/SMAD3/LEMD3/TGIF2/FMOD/TGIF1/NEO1/ACVR1/INHBB/ACVR1B/TGFB3/INHBA	2.35676930676808
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	34/2485	91/9376	1.40970659119552	RASGRP3/VAV3/AKT3/PPP3CA/NFATC1/PPP3CC/GSK3B/NFATC2/PLCG2/NFKB1/MAPK1/NFKBIA/KRAS/LYN/MAPK3/RAF1/SOS2/BCL10/CD81/NFATC3/IKBKB/PPP3R1/PPP3CB/RAC1/MALT1/HRAS/PIK3CA/RELA/PIK3R3/PIK3CB/NFKBIB/AKT1/NRAS/NFKBIE	2.35836164248714
Human Diseases	Cancer: specific types	hsa05218	Melanoma	28/2485	73/9376	1.44719274551418	AKT3/CDKN1A/BRAF/POLK/IGF1R/CCND1/MAPK1/FGFR1/KRAS/MAPK3/PDGFA/RAF1/HRAS/PIK3CA/GADD45A/GADD45B/PIK3R3/MDM2/MITF/PIK3CB/PDGFD/DDB2/AKT1/NRAS/E2F3/ARAF/GADD45G/MET	2.30330992535532
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	45/2485	128/9376	1.32645875251509	GUK1/PDE7B/PDE2A/ADCY4/PDE8A/NT5C2/NT5E/PNP/PDE4B/PDE1A/AK2/NME2/NME1/NME3/DGUOK/ENTPD4/AK3/GMPS/PDE4D/GART/NUDT16/AK1/NME7/PGM1/FHIT/NTPCR/ADCY9/NPR1/PDE6D/PDE7A/IMPDH1/GMPR2/PAICS/ADSL/PGM2/PRPS2/RRM2B/ADCY6/ADA/RRM1/AK4/ATIC/LACC1/PDE4A/ENTPD5	2.23314591376427
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	48/2485	138/9376	1.31236112326131	SHC1/FOXO1/AKT3/CBLB/BRAF/PRKAG2/PRKAR1B/FLOT1/PRKCZ/GSK3B/HK1/SOCS2/SORBS1/MAPK1/MAPK8/KRAS/MAPK3/PRKAA2/RHOQ/RAF1/SOS2/ACACA/PTPN1/INSR/IKBKB/PPP1CC/HRAS/PIK3CA/EIF4E2/PRKAA1/RPS6KB1/CBL/PIK3R3/SHC2/PIK3CB/MKNK2/G6PC3/PRKAG1/AKT1/NRAS/CALML4/SOCS4/ARAF/PYGB/PRKCI/ACACB/GYS1/SOCS1	2.21980717042449
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	54/2485	158/9376	1.28951939485011	RPS6KA2/AKT3/GRB10/BRAF/RPS6KA3/FNIP1/LPIN2/GSK3B/RNF152/IGF1R/MAPK1/CAB39/FNIP2/KRAS/MAPK3/PRKAA2/FZD6/RAF1/SOS2/INSR/LRP5/ATP6V1D/IKBKB/CLIP1/RICTOR/STRADA/HRAS/PRR5/PRR5L/PIK3CA/SEC13/EIF4E2/PRKAA1/RPS6KB1/PIK3R3/ULK1/PIK3CB/SEH1L/RRAGB/FLCN/DDIT4/AKT1/ATP6V1H/SLC7A5/NRAS/WNT2B/SLC38A9/NPRL3/RRAGC/WNT5A/DEPDC5/DEPTOR/AKT1S1/WNT9A	2.20391866877958
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	36/2485	99/9376	1.37201390159137	SHC1/AKT3/CDKN1A/ADCY4/BRAF/MMP2/NCOR1/PTK2/IGF1R/CCND1/MAPK1/NCOA3/MAPK8/KRAS/MAPK3/RAF1/SOS2/CDKN2C/HRAS/GNAS/NOTCH1/PIK3CA/MAPK14/RPS6KB1/PIK3R3/SHC2/DLL4/MDM2/BCL2/PIK3CB/ADCY9/AKT1/NRAS/E2F3/ARAF/ADCY6	2.2345017436199
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	43/2485	122/9376	1.32984134314081	SHC1/AKT3/CREB5/PLCB4/ADCY4/STAT3/BCAR1/PTK2/GSK3B/SOCS2/PLCG2/CREB1/MAPK1/MAP3K1/CREBBP/PLCB1/MAPK8/KRAS/STAT5B/MAPK3/MAP2K4/ATF2/RAF1/SOS2/GHR/HRAS/GNAS/PIK3CA/STAT1/MAPK14/MAP2K3/PIK3R3/SHC2/PIK3CB/ADCY9/PLCG1/AKT1/NRAS/ADCY6/STAT5A/ITPR3/CACNA1C/SOCS1	2.20205401538113
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	49/2485	142/9376	1.30196389605237	AKT3/TGFBR2/JAK1/PPP3CA/SQSTM1/FYN/NFATC1/RELB/PPP3CC/TGFB2/NFATC2/PLCG2/PPARG/CREB1/NFKB1/MAPK1/NFKBIA/ATP2A2/MAPK8/SIRPA/MAPK3/GAB2/FHL2/FOSL1/IKBKB/PPP3R1/PPP3CB/RAC1/TNFRSF11A/PIK3CA/JUND/STAT1/RELA/TAB2/MAPK14/PIK3R3/IRF9/MITF/PIK3CB/CSF1/MAP3K14/NFKB2/AKT1/TRAF6/ITGB3/TYK2/TRAF2/ITPR3/SOCS1	2.17726838789703
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	42/2485	119/9376	1.33166055154456	AKT3/CREB5/IRF1/CREB1/NFKB1/MAPK1/RIPK1/NFKBIA/DNM1L/MAPK8/MAPK3/MAP2K4/ATF2/ITCH/ADAM17/XIAP/TRAF3/IKBKB/PIK3CA/RELA/TAB2/CASP7/MAPK14/CASP10/MAP2K3/TNFAIP3/PIK3R3/PIK3CB/CASP3/BCL3/FRMD8/CSF1/MAP3K14/AKT1/MLKL/IL15/LIF/TAB3/TRAF5/CXCL1/RHBDF1/TRAF2	2.18645164595965
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	27/2485	71/9376	1.43481735483322	AKT3/PKM/GLS/HK1/MYC/HIF1A/MAPK1/LDHA/FGFR1/KRAS/MAPK3/RAF1/PFKL/HRAS/PIK3CA/PFKP/PIK3R3/PIK3CB/PDHA1/AKT1/SLC7A5/NRAS/RET/SIRT3/SCO2/MET/SIRT6	2.2084397991474
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	25/2485	65/9376	1.4511685497601	PNPLA2/MGLL/DGKH/PLPP1/LPIN2/AGPAT4/AGPAT5/AKR1A1/ALDH9A1/ALDH2/AGPAT3/DGKE/ALDH3A2/LCLAT1/GLA/GPAT4/MBOAT1/MBOAT2/GPAT3/DGKD/AGK/PLPP5/AGPAT2/PLPP2/DGKA	2.19182079411925
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	58/2485	173/9376	1.26494923297007	DNAJB1/AKT3/JAK1/RAB11A/FDPS/SLC25A6/DNAJC3/TNFRSF10B/CALCOCO2/NFKB1/MAPK1/NFKBIA/CREBBP/ADAR/NUP98/TBK1/EIF2S1/MAPK3/CCND3/VDAC1/RAF1/RAB11B/CYCS/XPO1/EIF2AK2/TRAF3/NXT1/KPNA1/HNRNPUL1/IKBKB/HLA-DPB1/PML/IRF3/PIK3CA/HLA-DRB1/STAT1/RELA/BID/PIK3R3/IRF9/HLA-DPA1/PIK3CB/NFKBIB/HLA-DQB1/CASP3/OAS1/IRAK4/KPNA5/AKT1/APAF1/MX1/TRIM25/ACTG1/TICAM1/TYK2/IRF7/MX2/HLA-DQA1	2.11216925600996
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	51/2485	150/9376	1.28283299798793	SHC1/AKT3/TGFBR2/CDKN1A/TCF7L1/JUP/CTNNA1/GAB1/BRAF/TGFB2/POLK/SMAD2/GSK3B/MYC/CCND1/MAPK1/KRAS/MAPK3/APC/FZD6/SMAD4/RAF1/SOS2/TCF7L2/LRP5/HRAS/PIK3CA/GADD45A/GADD45B/RPS6KB1/PIK3R3/SHC2/BCL2/PIK3CB/SMAD3/DDB2/AKT1/NRAS/RXRA/WNT2B/MLH1/E2F3/WNT5A/ARAF/GADD45G/TGFB3/WNT9A/MET/AXIN1/CDK2/TCF7	2.09689503400927
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	14/2485	32/9376	1.65070422535211	PCCA/HADHA/LDHA/ACACA/SUCLG1/ECHS1/HIBCH/ACADS/BCKDHB/ACSS2/BCKDHA/ACACB/ACOX3/MCEE	2.2141136577922
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	52/2485	155/9376	1.26579347050042	COLEC12/ITGAV/TUBB6/HLA-C/HLA-A/HLA-B/TUBA1A/TUBB4B/DYNC1H1/STX12/DYNC1I2/VAMP3/HLA-E/ITGA5/EEA1/SEC61B/RAB7A/THBS1/DYNC1LI2/HLA-F/MSR1/MRC1/STX7/SEC61G/RAB5A/DYNC1LI1/ITGB1/SEC61A1/ATP6V1D/C1R/HLA-DPB1/RAC1/DYNC1I1/PLA2R1/HLA-DRB1/PIK3C3/HLA-DPA1/HLA-DQB1/DYNC2H1/TUBA4A/ATP6V1H/HGS/RILP/ATP6V0A2/TCIRG1/ACTG1/CLEC4M/ITGB3/TAP2/SEC61A2/THBS3/HLA-DQA1	2.00368227196731
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	26/2485	70/9376	1.40141419948261	AKT3/STAT3/PRKAG2/CAMKK2/PTPN11/NFKB1/NFKBIA/MAPK8/PRKAA2/CPT1A/ACSL3/ACSL4/IKBKB/RELA/PRKAA1/ACSL5/NFKBIB/G6PC3/PRKAG1/AKT1/RXRA/PRKCQ/PPARA/NFKBIE/ACACB/TRAF2	2.0242676594178
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	26/2485	70/9376	1.40141419948261	SNTB2/HLA-C/HLA-A/HLA-B/CD55/FYN/HLA-E/ABL2/HLA-F/CCND1/CYCS/EIF4G1/HLA-DPB1/RAC1/ABL1/HLA-DRB1/SGCE/BID/HLA-DPA1/HLA-DQB1/CASP3/SGCD/CXADR/ACTG1/HLA-DQA1/DMD	2.0242676594178
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	33/2485	93/9376	1.33882001687545	JAK1/PPP3CA/NFATC1/PPP3CC/NFATC2/NFKB1/MAPK1/NFKBIA/MAPK8/STAT5B/MAPK3/NFATC3/IKBKB/HLA-DPB1/PPP3R1/PPP3CB/NOTCH1/HLA-DRB1/STAT1/RELA/MAPK14/MAML2/DLL4/HLA-DPA1/NFKBIB/HLA-DQB1/PLCG1/MAML1/PRKCQ/STAT5A/TYK2/NFKBIE/HLA-DQA1	1.97185087992105
Cellular Processes	Cell motility	hsa04814	Motor proteins	63/2485	194/9376	1.22526499201394	MYO1D/MYH10/TUBB6/TUBA1A/TPM4/TUBB4B/DYNC1H1/TPM2/DYNC1I2/MYH9/ACTG2/DCTN2/HOOK3/KLC1/STARD9/MYL9/DYNLL1/KIF13A/MYO5C/KIFAP3/DYNLT1/MYL12A/DYNC1LI2/MYO9A/MYO6/MYO1B/DCTN3/KIF2A/ACTA2/MYO1E/MYL6B/TPM3/KIF1B/DYNC1LI1/MYL12B/KIF9/KIF13B/MYH11/MYO9B/DYNC1I1/KIF3C/MYL6/KIF1C/ACTR1A/MYO18A/DYNLT3/KIFC3/KIF26B/DCTN1/DYNC2H1/TUBA4A/KIF3B/ACTR1B/MYO15B/DNAL1/DNAH14/MYO19/ACTG1/KIF17/KIF27/KIF3A/DYNC2LI1/TUBG2	1.90385397313363
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	44/2485	130/9376	1.27702832378889	SHC1/GNG12/AKT3/TGFBR2/CREB5/PLCB4/ADCY4/GNB1/MMP2/EDNRB/SMAD2/PRKCZ/ARRB1/CREB1/ACTA2/NFKB1/MAPK1/NFKBIA/PLCB1/MAPK8/KRAS/MAPK3/MAP2K4/ATF2/GNB4/GNG5/RAF1/SOS2/GNG11/GNB5/HRAS/GNAS/COL4A5/PIK3CA/RELA/MAPK14/PIK3R3/SHC2/PIK3CB/ADCY9/AKT1/NRAS/ADCY6/VEGFA	1.90997030703561
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	59/2485	181/9376	1.22988538968618	AKT3/JAK1/PPP3CA/CAMK2D/HSPD1/SPHK1/ARHGEF12/PPP3CC/TGFB2/EEA1/HSPA9/RAB7A/CREB1/NFKB1/MRC1/MAPK1/CREBBP/RAB5A/MAPK8/MAPK3/RAF1/CYCS/BCL10/IRAK2/HLA-DPB1/PPP3R1/PPP3CB/PLK3/MALT1/RIPK2/PLA2R1/HLA-DRB1/STAT1/RELA/MAPK14/NFYC/CASP10/BID/PIK3C3/RFXANK/BCL2/HLA-DPA1/HLA-DQB1/CASP3/KSR1/IRAK4/CAMK2G/AKT1/ATP6V1H/APAF1/CALML4/TRAF6/CEBPG/ATP6V0A2/TCIRG1/CLEC4M/TGFB3/NFYA/HLA-DQA1	1.87535072666834
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	26/2485	71/9376	1.38167597132088	ADAM10/TJP1/NOD1/F11R/PLCG2/PTPN11/NFKB1/NFKBIA/MAPK8/LYN/MAP2K4/ADAM17/ATP6V1D/IKBKB/GIT1/RAC1/RELA/MAPK14/CASP3/MAP3K14/PLCG1/ATP6V1H/ATP6V0A2/TCIRG1/CXCL1/MET	1.93853441237777
NA	NA	hsa04518	Integrin signaling	51/2485	154/9376	1.24951266037785	RELN/LAMA4/FLT4/ACTN1/LIMS1/AKT3/ITGAV/TNXB/ITGA9/ITGA1/FLNA/VWF/PARVA/FLNB/LAMB2/TLN1/ITGA5/PTK2/GSK3B/PXN/THBS1/FERMT2/ITGA6/ILK/IGF1R/CCND1/PDGFA/VCL/PARVB/CCND3/LAMB1/LAMC1/ITGB1/RAC1/COL4A5/NCK2/PIK3CA/ITGB4/PGF/PIK3R3/PIK3CB/PDGFD/AKT1/TNC/ACTG1/ITGB3/MET/ITGA8/VEGFA/NPNT/THBS3	1.87477044341592
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	58/2485	178/9376	1.22941695114507	ROCK2/PPP3CA/TCF7L1/PLCB4/CAMK2D/CTBP2/DAAM1/NFATC1/PPP3CC/TLE1/GSK3B/TBL1XR1/NFATC2/RYK/MYC/ANKRD6/CUL1/CCND1/CSNK1E/CACYBP/CREBBP/FBXW11/PLCB1/MAPK8/CSNK2A1/CSNK2B/CCND3/APC/FZD6/SMAD4/TCF7L2/FOSL1/CSNK2A2/CELSR1/LRP5/NFATC3/PPP3R1/PPP3CB/TBL1X/RAC1/SFRP1/PSEN1/INVS/PPARD/BTRC/CHD8/SMAD3/SENP2/CBY1/SIAH1/CAMK2G/WNT2B/WNT5A/VANGL1/WNT9A/CCDC88C/AXIN1/TCF7	1.85565190665657
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	17/2485	43/9376	1.49166627673015	HADHA/ACAT1/HADHB/CPT1A/ACSL3/ALDH9A1/ALDH2/ACSL4/ECI2/ECHS1/ACSL5/ACADM/ACADS/ALDH3A2/ACAA1/ACAT2/ACOX3	1.94044673454026
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	15/2485	37/9376	1.52961009299037	GMDS/HK1/UGP2/GPI/UAP1/GALK2/UGDH/PGM1/PMM2/CMAS/GALK1/GNE/PGM2/GNPNAT1/GFPT2	1.93827162106042
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	27/2485	75/9376	1.35829376257545	AKT3/CDKN1A/MGST2/MGST3/GSTO1/REV3L/MAPK1/MAPK3/CYCS/XIAP/ERCC1/PIK3CA/BID/PIK3R3/MDM2/BCL2/PIK3CB/XPA/CASP3/AKT1/APAF1/GSTM3/MLH1/BBC3/GSTT2B/MGST1/POLH	1.87073713389814
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	21/2485	56/9376	1.4148893360161	DAD1/MAN2A1/KRTCAP2/TUSC3/DPM3/MAN1A1/TMEM258/MGAT5/MAN1A2/MAGT1/ST6GAL1/ALG13/STT3B/MGAT4B/DPM2/SRD5A3/DPAGT1/B4GALT3/MGAT4C/ALG8/B4GALT2	1.86993297133848
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	21/2485	56/9376	1.4148893360161	HSPA8/HSPD1/HSPA1A/HSPA1B/VCP/HSPA6/NFKB1/NFKBIA/CLK1/CYCS/BNIP3/RELA/CASP7/HSF1/BCL2L13/CASP3/HBS1L/NFKB2/APAF1/CLK4/CXCL1	1.86993297133848
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	7/2485	14/9376	1.88651911468813	ST3GAL1/ST3GAL2/ST3GAL3/B3GNT7/B4GALT3/B4GALT2/B4GALT4	1.99331306494572
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	9/2485	20/9376	1.69786720321932	CYB5R3/GMDS/UGP2/UAP1/CYB5RL/UGDH/CYB5R1/CMAS/GNE	1.87607583650528
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	13/2485	32/9376	1.5327967806841	BIRC6/MAPK8/CYCS/XIAP/BECN1/CASP7/BID/BCL2L11/BCL2/CASP3/BOK/APAF1/BBC3	1.81291681070926
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	44/2485	134/9376	1.23890807531758	CALCRL/PRKCH/MYH10/ROCK2/PRKG1/PLCB4/ADCY4/BRAF/MYH9/ACTG2/ARHGEF12/PRKCE/MYL9/ADM/PLA2G4C/ACTA2/ROCK1/MAPK1/MYL6B/PLCB1/MAPK3/RAF1/MYH11/GNA12/PPP1CC/GNAS/CALD1/MYL6/PPP1R12B/RAMP1/PPP1R12C/ARHGEF11/ADCY9/NPR1/RAMP3/PLA2G6/CALML4/ARAF/PRKCQ/PLA2G12A/ADCY6/ITPR3/KCNMB3/CACNA1C	1.67266109812009
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	36/2485	107/9376	1.26943342296771	FOXO1/AKT3/CREB5/PPP3CA/PLCB4/CAMK2D/PRKAG2/PKM/PPP3CC/SIK2/CREB1/LDHA/CREBBP/PLCB1/ATF2/PRKAA2/CPT1A/ACACA/PPP4R3B/PPP3R1/PPP3CB/PFKL/GNAS/PFKP/PRKAA1/G6PC3/PRKAG1/PDHA1/CAMK2G/AKT1/CALML4/PYGB/PPARA/ACACB/GYS1/ITPR3	1.68319575077494
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	63/2485	201/9376	1.18259407189405	SMAD1/FOXO1/TGFBR2/ZEB1/NUPR1/ERG/CDKN1A/JUP/JMJD1C/LMO2/ETV6/FUS/TAF15/NCOR1/PTK2/POLK/KMT2A/KDM6A/MYC/PPARG/IGF1R/DDX5/DDIT3/NFKB1/MAX/BMP2K/REL/FLI1/PDGFA/DUSP6/HDAC1/MLF1/ELK4/CCNT2/SIN3A/CDKN2C/PLAT/ZBTB16/TSPAN7/PML/RELA/GADD45A/HDAC2/GADD45B/PBX1/HHEX/MDM2/MITF/CCNT1/RUNX1T1/DDB2/PBX3/RARA/NSD2/ATF1/RXRA/ZBTB17/TFE3/BCL6/SLC45A3/GADD45G/DOT1L/MET	1.57140950461505
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	6/2485	12/9376	1.88651911468813	VKORC1/VKORC1L1/COQ4/COQ2/COQ7/COQ6	1.84525221097666
Genetic Information Processing	Transcription	hsa03040	Spliceosome	75/2485	243/9376	1.16451797202971	HSPA8/HSPA1A/HSPA1B/SNRPB/FUS/SF1/SRSF4/SNU13/RBM25/TRA2A/DDX46/HNRNPA3/HNRNPC/DDX39B/HNRNPM/SRSF10/HNRNPU/SRSF2/SNW1/HSPA6/SNRPD2/DDX5/SF3B1/RBMX/SNRNP70/DHX15/RBM8A/PRPF38B/LSM2/SNRPD1/PRPF40A/SF3B2/SRSF7/CDC5L/TCERG1/EIF4A3/SNRPB2/CWC25/ACIN1/BCAS2/DDX42/THOC1/SMNDC1/ZMAT2/CASC3/SNRPA1/SNRPA/SNRNP27/CTNNBL1/SLU7/SF3A3/PRPF18/SF3B3/RBM22/SF3A2/NCBP2/DHX8/ISY1/CDC40/PPIE/PRPF3/SNIP1/SNRNP200/PQBP1/SF3A1/DDX23/DHX38/PLRG1/PHF5A/U2AF2/NCBP1/MAGOHB/PRPF4/U2AF1L4/DHX16	1.5603336163725
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	72/2485	233/9376	1.16591739276863	PDLIM1/LMNA/SNTB2/SYNE1/MYH10/ITGAV/SPTBN1/JUP/ITGA9/TPM4/FHL1/ITGA1/TPM2/MYH9/ACTG2/HSPG2/PDLIM3/DES/DAAM1/TMOD3/DSP/TLN1/ITGA5/MYL9/DIAPH2/PDLIM4/CSRP1/ENO1/THBS1/SUN1/ATP1A1/DIAPH1/PDLIM2/ITGA6/FLNC/FHL3/LBR/SUN2/PLEC/TPM3/VIM/SDC4/VCL/ATP1B3/FHL2/FMNL3/SDC3/TMOD2/NID1/ITGB1/MYH11/COL5A2/ELN/ZYX/COL4A5/TTN/ITGB4/SGCE/PDLIM7/TMOD1/EMD/SGCD/INF2/ACTG1/SYNE3/ITGB3/OBSCN/ITGA8/LMOD1/AGRN/THBS3/DMD	1.54004434011934
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	12/2485	30/9376	1.5092152917505	GPAA1/DPM2/PIGG/PIGC/PIGK/PIGP/PIGH/PGAP2/PIGZ/PIGL/PIGA/PIGQ	1.67747820358782
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	7/2485	15/9376	1.76075117370892	ST6GALNAC3/ST3GAL1/ST8SIA1/ST3GAL2/ST6GALNAC6/SLC33A1/ST6GALNAC4	1.770658659713
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	25/2485	72/9376	1.31008271853342	NFKB1/RIPK1/MAP3K1/NFKBIA/ADAR/MAPK8/TBK1/ISG15/DDX3X/TRAF3/ZNFX1/ATG5/IKBKB/IRF3/RELA/ATG12/MAPK14/CASP10/OTUD5/NFKBIB/TRAF6/TRIM25/IRF7/TRAF2/SIKE1	1.58604925412829
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	28/2485	82/9376	1.28835451734799	HSPA8/HLA-C/HLA-A/HSP90AA1/HLA-B/HSPA1A/HSPA1B/HSPA4/HLA-E/HSPA5/HSP90AB1/PSME1/PSME2/HLA-F/HSPA6/CREB1/TAPBP/HLA-DPB1/HLA-DRB1/NFYC/RFXANK/HLA-DPA1/HLA-DQB1/PSME3/TAPBPL/TAP2/NFYA/HLA-DQA1	1.57485314233705
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	24/2485	69/9376	1.31236112326131	VAV3/AKT3/FYN/PLA2G4C/PLCG2/MAPK1/MAPK8/KRAS/LYN/MAPK3/GAB2/MAP2K4/RAF1/SOS2/RAC1/HRAS/PIK3CA/MAPK14/MAP2K3/PIK3R3/PIK3CB/PLCG1/AKT1/NRAS	1.56381139757366
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	49/2485	154/9376	1.20051216389245	VKORC1/MTHFD1L/GUSB/GPHN/AK2/PTS/NME2/MAT2A/AKR1A1/NME1/NME3/UGP2/GCH1/VKORC1L1/ALDH2/AK3/BCAT1/CMPK1/PANK3/DHODH/RFK/AK1/RDH11/NME7/UGDH/PMM2/GSS/COQ4/ALDH3A2/UROS/NMNAT2/ALAS1/PPCDC/ADSL/GCLC/CTPS2/COQ2/FPGS/COQ7/NADSYN1/CTPS1/SPR/AK4/PNPO/BCAT2/MMAB/PPOX/COQ6/LIAS	1.5065940054571
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	36/2485	110/9376	1.23481251143223	RPS6KA2/AKT3/HSP90AA1/ADCY4/BRAF/RPS6KA3/ANAPC5/ANAPC16/CDC27/HSP90AB1/IGF1R/MAPK1/MAPK8/KRAS/MAPK3/RAF1/CDC26/CDC16/PIK3CA/MAPK14/PIK3R3/CPEB3/ANAPC7/CPEB2/PIK3CB/ADCY9/AKT1/ANAPC10/ANAPC1/ARAF/ADCY6/MAD2L2/ANAPC4/FZR1/CDK2/SPDYE2	1.48757591429065
Organismal Systems	Nervous system	hsa04730	Long-term depression	21/2485	60/9376	1.32056338028169	PRKG1/PLCB4/BRAF/PPP2CB/PLA2G4C/IGF1R/MAPK1/PLCB1/KRAS/LYN/MAPK3/PPP2CA/PPP2R1B/RAF1/GNA12/HRAS/GNAS/NRAS/ARAF/GRIA1/ITPR3	1.49583091260656
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	20/2485	57/9376	1.32387306293904	ELOVL5/HADHA/ACAT1/HADHB/ELOVL1/TECR/CPT1A/ACSL3/ACACA/ACSL4/ECHS1/ACSL5/ACADM/ACADS/HACD2/ACAA1/HACD1/ACAT2/MECR/ACOX3	1.47277129258792
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	31/2485	94/9376	1.24429984160281	HSP90AA1/ANAPC5/GSK3B/HSP90AB1/USP25/NFKB1/MAPK1/NFKBIA/MAPK8/TBK1/MAPK3/FOSL1/TRAF3/IKBKB/MAPK6/ELAVL1/JUND/RELA/TAB2/MAPK14/TNFAIP3/HSP90B1/CASP3/TRAF6/MAPK7/TAB3/TRAF3IP2/CSF3/TRAF5/CXCL1/TRAF2	1.42946669070798
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	15/2485	41/9376	1.3803798400157	SEM1/POLD4/BABAM2/UIMC1/MRE11/POLD2/RBBP8/BARD1/POLD3/NBN/RAD50/TOPBP1/TOP3A/ABRAXAS1/BRCC3	1.4657502213117
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	37/2485	115/9376	1.21393403901671	CREB5/CDKN1A/PLCB4/ADCY4/BRAF/ARRB1/PLD1/WNK1/PDE4B/CREB1/MAPK1/FGFR1/PLCB1/MAPK3/ATF2/RAF1/AKAP13/LRP5/GNA12/MEF2A/PDE4D/GNAS/JUND/MMP16/BCL2/MEF2D/ARHGEF11/STK39/ADCY9/MMP17/RXRA/ARAF/ADCY6/MMP24/NACA/ITPR3/PDE4A	1.38614153926574
Organismal Systems	Immune system	hsa04611	Platelet activation	40/2485	126/9376	1.1977899140877	AKT3/ROCK2/PRKG1/PLCB4/ADCY4/FYN/VWF/RAP1B/ARHGEF12/TLN1/PRKCZ/PLA2G4C/SNAP23/MYL12A/PLCG2/ROCK1/MAPK1/RAP1A/PLCB1/LYN/MAPK3/MYL12B/STIM1/ITGB1/F2R/PPP1CC/GNAS/PIK3CA/MAPK14/PIK3R3/PIK3CB/ARHGAP35/ADCY9/AKT1/F2RL3/ACTG1/ADCY6/ITGB3/PRKCI/ITPR3	1.34222788709383
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	42/2485	133/9376	1.19148575664513	GNG12/AKT3/CREB5/PPP3CA/PLCB4/CAMK2D/PPP3CC/PPP2CB/GNB1/GSK3B/ARRB1/PPP2R5C/CREB1/PPP2R5E/PLCB1/MAPK8/PPP2R3C/ATF2/GNB4/PPP2CA/PPP2R1B/GNG5/PPP2R2D/PPP2R5A/GNG11/PPP3CB/PPP1CC/GNB5/GNAS/CLOCK/MAPK14/PPP2R3A/CAMK2G/AKT1/CALML4/PPP2R5D/PPP2R5B/GRIA1/GRIN2B/ITPR3/CACNA1C/MAOB	1.33556038594007
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	45/2485	144/9376	1.17907444668008	FOXO1/AKT3/TCF7L1/PRKAG2/CAMKK2/TRA2A/LPIN2/GSK3B/CCND1/NFKB1/RIPK1/NFKBIA/MAPK8/TBK1/MAP2K4/PRKAA2/CPT1A/ALDH9A1/ACACA/TCF7L2/ALDH2/TRAF3/IKBKB/IRF3/RELA/TAB2/MAPK14/PRKAA1/MAP2K3/ACADM/NOX4/CASP3/ALDH3A2/PRKAG1/MAP3K14/IRAK4/AKT1/TRAF6/TAB3/TICAM1/PPARA/CXCL1/ACACB/TCF7/ACOX3	1.30039315810387
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	19/2485	55/9376	1.3034132065118	SPHK1/CERS6/PLPP1/B4GALT5/UGCG/ACER3/KDSR/SPTLC1/CERK/CERS2/CERS5/GLA/ACER2/GBA2/CERS4/SGMS2/PLPP2/SMPD1/SGPL1	1.35516532500266
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	46/2485	148/9376	1.17270107129262	FLT4/SHC1/AKT3/CDKN1A/TCF7L1/BRAF/HES1/POLK/GSK3B/MYC/IGF1R/CCND1/MAPK1/NCOA3/FGFR1/KRAS/MAPK3/APC/FZD6/RAF1/SOS2/TCF7L2/LRP5/NCOA1/HRAS/NOTCH1/PIK3CA/GADD45A/GADD45B/RPS6KB1/PIK3R3/SHC2/DLL4/PIK3CB/DDB2/NFKB2/AKT1/NRAS/WNT2B/E2F3/WNT5A/ARAF/GADD45G/WNT9A/AXIN1/TCF7	1.27168575392144
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	30/2485	93/9376	1.21710910625041	PLCB4/CAMK2D/ADCY4/MMP2/MAP3K3/PLA2G4C/PLD1/MAPK1/MAP3K1/PLCB1/MAPK8/KRAS/MAPK3/MAP2K4/RAF1/SOS2/MAP3K2/HRAS/GNAS/MAP3K4/MAPK14/MAP2K3/ADCY9/CAMK2G/NRAS/CALML4/MAPK7/ADCY6/ITPR3/CACNA1C	1.26352269900309
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	17/2485	49/9376	1.30901326325299	GALNT18/GALNT1/GALNT10/OGT/GALNT11/ST6GAL1/XXYLT1/GALNT2/GXYLT1/ST3GAL3/FUT11/C1GALT1C1/RFNG/B4GALT3/POFUT1/B4GALT2/GALNT6	1.30230252236179
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	9/2485	23/9376	1.47640626366897	FDPS/ACAT1/FNTA/PMVK/PDSS2/ACAT2/DHDDS/FNTB/HMGCR	1.37364219693213
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	9/2485	23/9376	1.47640626366897	RFC1/POLD4/POLD2/POLD3/RFC2/MLH1/MLH3/PMS2/LIG1	1.37364219693213
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	27/2485	83/9376	1.22737388184529	PRDX1/SOD2/SOD1/GSTK1/FAR2/FAR1/ACSL3/ECH1/ACSL4/ECI2/PMVK/PXMP2/ACSL5/GNPAT/MPV17/PEX14/ABCD4/SLC25A17/PHYH/ACAA1/PEX11B/CRAT/PEX13/PEX10/PEX16/PECR/ACOX3	1.2494226183736
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	44/2485	142/9376	1.16911043727152	AKT3/ITGAV/HSP90AA1/SQSTM1/TXN/MGST2/MGST3/GSTO1/MMP2/PTK2/PRKCZ/NFE2L2/HSP90AB1/SUMO3/NFKB1/MAPK8/SDC4/PDGFA/THBD/MAP2K4/PRKAA2/PLAT/IKBKB/MEF2A/RAC1/PIK3CA/RELA/MAPK14/PRKAA1/PIK3R3/HSP90B1/BCL2/PIK3CB/HMOX1/AKT1/CALML4/GSTM3/ACVR1/MAPK7/ACTG1/ITGB3/GSTT2B/VEGFA/MGST1	1.21934712708455
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	13/2485	36/9376	1.36248602727476	ST6GALNAC3/GALNT18/GALNT1/B4GALT5/ST3GAL1/GALNT10/GALNT11/GCNT1/GALNT2/ST3GAL2/C1GALT1C1/ST6GALNAC4/GALNT6	1.308509236414
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	7/2485	17/9376	1.55360397680199	NRP2/MYH10/MYH9/MYH11/PCDH9/CLEC4M/PCDH7	1.37188165292295
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	12/2485	33/9376	1.37201390159137	IDH3B/BCAT1/ACO1/DLST/ACO2/BCKDHB/PDHA1/GOT2/IDH3A/BCKDHA/DHTKD1/BCAT2	1.28552543654436
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	11/2485	30/9376	1.38344735077129	MDH2/ACLY/SUCLG1/SDHB/IDH3B/ACO1/DLST/ACO2/SDHA/PDHA1/IDH3A	1.26316821894951
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	47/2485	154/9376	1.15151166740704	ROCK2/PPP3CA/CDKN1A/PLCB4/CAMK2D/ADCY4/PRKAG2/NFATC1/PPP3CC/CAMKK2/MYL9/PLA2G4C/NFATC2/CCND1/ROCK1/MAPK1/MYL6B/PLCB1/KRAS/MAPK3/PRKAA2/RAF1/NFATC3/PPP3R1/PPP3CB/PPP1CC/HRAS/GNAS/MYL6/PPP1R12B/PRKAA1/CAMK1/PPP1R12C/ADCY9/PRKAG1/NPR1/CAMK2G/NRAS/CD38/CALML4/MAPK7/ACTG1/ADCY6/CACNB2/ITPR3/CACNA1C/OXTR	1.13841756749829
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	16/2485	47/9376	1.28443854617064	PKM/ACAT1/LDHA/MDH2/ACYP2/AKR1A1/ALDH9A1/ACACA/ALDH2/ME3/ALDH3A2/PDHA1/ACSS2/ACYP1/ACAT2/ACACB	1.17389037675905
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	16/2485	47/9376	1.28443854617064	PKM/PRKCE/PRKCZ/HK1/SOCS2/MAPK1/MAPK8/MAPK3/INSR/IKBKB/PIK3CA/PIK3R3/PIK3CB/SOCS4/CACNA1C/SOCS1	1.17389037675905
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	15/2485	44/9376	1.28626303274191	DAD1/MAN2A1/KRTCAP2/TUSC3/MAN1A1/TMEM258/MAN1A2/MAGT1/ALG13/STT3B/MGAT4B/ST3GAL3/B4GALT3/MGAT4C/B4GALT2	1.1429097850401
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	15/2485	44/9376	1.28626303274191	TAF15/TBPL1/TAF10/TAF3/TAF11/TAF2/GTF2E2/GTF2H1/GTF2F2/GTF2F1/TAF13/CDK7/GTF2H4/TAF5L/ERCC2	1.1429097850401
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8/2485	21/9376	1.43734789690524	CSGALNACT1/CHSY3/CHST15/CHST12/B3GAT3/DSEL/CHST7/B4GALT7	1.20482093069019
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	17/2485	51/9376	1.25767940979209	TJP1/KDELR1/SEC61B/PLCG2/SEC61G/TJP2/SEC61A1/ATP6V1D/GNAS/ADCY9/SLC12A2/PLCG1/ATP6V1H/ATP6V0A2/TCIRG1/ACTG1/SEC61A2	1.10802126311941
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	27/2485	86/9376	1.18455851387394	LMNA/SNTB2/ITGAV/TCF7L1/JUP/ITGA9/CTNNA1/ITGA1/DES/DSP/ITGA5/ITGA6/GJA1/ATP2A2/TCF7L2/ITGB1/ITGB4/SGCE/EMD/SGCD/ACTG1/ITGB3/CACNB2/ITGA8/TCF7/CACNA1C/DMD	1.03248360192557
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	13/2485	38/9376	1.29077623636556	HK1/UGP2/GPI/UAP1/GALK2/UGDH/PGM1/PMM2/GALK1/GNE/PGM2/GNPNAT1/GFPT2	1.0785281486319
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	13/2485	38/9376	1.29077623636556	NNMT/NT5C2/NT5E/PNP/SIRT2/NNT/CD38/NMNAT2/SIRT3/NADSYN1/BST1/SIRT5/SIRT6	1.0785281486319
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	13/2485	38/9376	1.29077623636556	SCNN1B/ATP1A1/MAPK1/KRAS/MAPK3/ATP1B3/INSR/NR3C2/PIK3CA/PIK3R3/PIK3CB/NEDD4L/FXYD2	1.0785281486319
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	10/2485	28/9376	1.34751365334866	ELOVL5/HADHA/HADHB/ELOVL1/TECR/ECHS1/HACD2/THEM4/HACD1/MECR	1.10585769861672
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	10/2485	28/9376	1.34751365334866	ST3GAL6/GCNT2/B3GNT5/A4GALT/ST8SIA1/ABO/ST3GAL3/B4GALT3/B4GALT2/B4GALT4	1.10585769861672
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	43/2485	144/9376	1.12667113793874	SMAD1/AKT3/JAK1/KAT6A/STAT3/JARID2/SMAD2/GSK3B/MYC/ZFHX3/IGF1R/MAPK1/FGFR1/SKIL/KRAS/MAPK3/APC/FZD6/SMAD4/RAF1/SMAD9/RIF1/HRAS/PIK3CA/MAPK14/PIK3R3/PIK3CB/SMAD3/PCGF3/SMARCAD1/AKT1/NRAS/WNT2B/SETDB1/ACVR1/LIF/WNT5A/INHBB/ACVR1B/WNT9A/AXIN1/TCF7/INHBA	0.919853637180593
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	11/2485	32/9376	1.29698189134809	HK1/UGP2/PFKL/PFKP/PGM1/G6PC3/GLA/GALK1/GANC/PGM2/B4GALT2	1.01052311654338
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	35/2485	116/9376	1.13841670713939	CLDN5/ACTN1/VAV3/CD99/AFDN/ROCK2/CTNND1/CTNNA1/RAP1B/BCAR1/MMP2/PTK2/MYL9/MSN/F11R/PXN/MYL12A/PLCG2/PTPN11/ROCK1/RAP1A/VCL/MYL12B/ITGB1/RAC1/PIK3CA/MAPK14/RAPGEF4/PIK3R3/PIK3CB/ARHGAP35/SIPA1/PLCG1/CD99L2/ACTG1	0.900782052258298
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	41/2485	138/9376	1.12097512611903	COX7A1/ATP5F1E/COX6A1/NDUFS7/NDUFB8/NDUFC1/COX7A2/NDUFB2/NDUFB11/NDUFB1/COX5A/NDUFA11/NDUFB7/ATP5MC1/NDUFB10/COX7A2L/NDUFS4/COX5B/ATP5ME/COX6B1/NDUFA6/NDUFS8/CYC1/CYCS/NDUFA10/UQCR11/NDUFV1/ATP6V1D/NDUFA4/COX6C/NDUFA8/SDHB/NDUFV3/NDUFA9/NDUFS2/COX4I1/PPA2/SDHA/ATP6V1H/ATP6V0A2/TCIRG1	0.859714709686798
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	30/2485	99/9376	1.14334491799281	LMNA/SNTB2/ITGAV/ITGA9/TPM4/ITGA1/PRKAG2/TPM2/DES/ITGA5/TGFB2/ITGA6/TPM3/ATP2A2/PRKAA2/ITGB1/TTN/ITGB4/PRKAA1/SGCE/EMD/PRKAG1/SGCD/ACTG1/ITGB3/CACNB2/TGFB3/ITGA8/CACNA1C/DMD	0.861001343830986
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	12/2485	36/9376	1.25767940979209	PGM2L1/HK1/GBE1/UGP2/GPI/PGM1/G6PC3/GYG1/GANC/PGM2/PYGB/GYS1	0.930176234051302
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	12/2485	36/9376	1.25767940979209	POLE4/RFC1/RNASEH2C/POLD4/POLD2/RNASEH1/POLD3/RFC2/MCM3/POLE/MCM7/LIG1	0.930176234051302
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	6/2485	16/9376	1.4148893360161	ST3GAL1/A4GALT/ST8SIA1/ABO/GLA/ST3GAL2	0.997383200680421
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	41/2485	139/9376	1.11291055686638	SHC1/AKT3/CREB5/HSPA8/HSP90AA1/PLCB4/ADCY4/HSPA1A/HSPA1B/MMP2/HSP90AB1/HSPA6/CREB1/MAPK1/NCOA3/PLCB1/KRAS/MAPK3/ATF2/RAF1/SOS2/GABBR1/FKBP4/NCOA1/HRAS/GNAS/PIK3CA/EBAG9/PIK3R3/SHC2/HSP90B1/BCL2/PIK3CB/ADCY9/RARA/AKT1/NRAS/CALML4/ADCY6/GREB1/ITPR3	0.805349118035793
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	5/2485	13/9376	1.4511685497601	XRCC5/XRCC6/MRE11/RAD50/DCLRE1C	0.977486329383158
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	17/2485	54/9376	1.1878083314703	CISD1/LDHA/MDH2/MAT2A/MTR/ADI1/MPST/BCAT1/GSS/MTAP/GOT2/AHCYL2/BHMT2/GCLC/TST/BCAT2/LACC1	0.831122222730649
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	23/2485	76/9376	1.14184051678492	FABP5/DBI/PLIN2/UBC/SORBS1/PPARG/ILK/CPT1A/ACSL3/FABP4/PLIN5/ACSL4/ME3/ACSL5/ACADM/PPARD/ACAA1/RXRA/CYP27A1/SLC27A4/PPARA/SLC27A1/ACOX3	0.745544098053227
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	34/2485	116/9376	1.10589051550683	PCCA/PKM/TPI1/HK1/ENO1/ESD/ACAT1/MDH2/TALDO1/ME3/GLUD1/SUCLG1/GAPDH/ECHS1/SDHB/IDH3B/PFKL/ACO1/GPI/HIBCH/PFKP/DLST/ACO2/ACADS/SDHA/PDHA1/ACSS2/GOT2/IDH3A/PGP/PRPS2/ACAT2/ACOX3/MCEE	0.689109557973241
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	29/2485	98/9376	1.11651131277461	CREB5/PLCB4/PDE2A/CAMK2D/ADCY4/ATP2B4/PRKCE/PRKD2/ATP2B1/ATP1A1/CREB1/NR4A1/PLCB1/ATF2/ATP1B3/PRKD1/PRKD3/GNAS/CAMK1/ADCY9/LDLR/NPR1/CAMK2G/ATF1/CALML4/DAGLB/ADCY6/ITPR3/CACNA1C	0.696244310335631
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	55/2485	193/9376	1.07521814826785	CCL21/CCL14/VAV3/SHC1/GNG12/AKT3/ROCK2/PLCB4/ADCY4/STAT3/BRAF/RAP1B/PARD3/BCAR1/GRK5/GNB1/PTK2/PRKCZ/GSK3B/PXN/ARRB1/PLCG2/ROCK1/NFKB1/MAPK1/NFKBIA/RAP1A/PLCB1/KRAS/LYN/STAT5B/MAPK3/GNB4/GNG5/RAF1/SOS2/GNG11/IKBKB/GNB5/RAC1/HRAS/PIK3CA/STAT1/RELA/ELMO1/PIK3R3/SHC2/PIK3CB/NFKBIB/ADCY9/PLCG1/AKT1/NRAS/ADCY6/CXCL1	0.634040076662193
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	10/2485	31/9376	1.21710910625041	PCCA/ACAT1/MDH2/ACO1/HYI/ACO2/ACSS2/PGP/ACAT2/MCEE	0.727071202037396
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	48/2485	168/9376	1.07801092267893	JAK1/HSP90AA1/SQSTM1/CAMK2D/STAT3/SLC25A6/CHMP3/CHMP4B/PLA2G4C/HSP90AB1/CHMP2A/CAPN2/TNFRSF10B/RIPK1/RBCK1/CHMP4A/DNM1L/MAPK8/TRPM7/STAT5B/VDAC1/XIAP/EIF2AK2/GLUD1/CHMP2B/STAT1/HMGB1/BID/PPIA/TNFAIP3/CHMP1B/BCL2/IRF9/SPATA2L/CAMK2G/CAPN1/MLKL/PPID/PYGB/STAT5A/TICAM1/TYK2/TRAF5/CHMP6/TRAF2/AIFM1/SMPD1/RNF31	0.612681983825178
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	30/2485	103/9376	1.09894317360474	AKT3/TGFBR2/PLCB4/PPP2CB/TGFB2/SMAD2/NFKB1/MAPK1/NFKBIA/PLCB1/MAPK8/MAPK3/MAP2K4/PPP2CA/PPP2R1B/PPP2R2D/GNA14/IKBKB/SERPINE1/GNAS/PIK3CA/RELA/MAPK14/PIK3R3/PIK3CB/IRAK4/AKT1/TRAF6/TICAM1/TGFB3	0.606320187689813
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	23/2485	78/9376	1.11256255481608	SERPING1/ITGA5/NOD1/IRF1/NFKB1/MAPK1/MAPK8/MAPK3/ITGB1/IRF8/C1R/CFL1/IRF3/CFL2/RELA/CASP7/MAPK14/C1S/CASP3/IRAK4/CALML4/TRAF6/TICAM1	0.599451680255581
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	26/2485	89/9376	1.10223588723351	RELN/LAMA4/ITGAV/TNXB/ITGA9/ITGA1/VWF/HSPG2/LAMB2/ITGA5/CD47/THBS1/SV2B/ITGA6/SDC4/LAMB1/LAMC1/ITGB1/COL4A5/ITGB4/TNC/ITGB3/ITGA8/NPNT/AGRN/THBS3	0.581926802670771
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	26/2485	89/9376	1.10223588723351	TUBB6/PRKG1/PLCB4/TUBA1A/ADCY4/TUBB4B/TJP1/GJA1/MAPK1/PLCB1/KRAS/MAPK3/PDGFA/RAF1/SOS2/MAP3K2/HRAS/GNAS/CSNK1D/PDGFD/ADCY9/TUBA4A/NRAS/MAPK7/ADCY6/ITPR3	0.581926802670771
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	16/2485	53/9376	1.1390304088683	RAB11A/PLCB4/AP2B1/ATP2B4/AP2M1/ATP2B1/ATP1A1/AP2A2/PLCB1/ATP1B3/GNAS/AP2A1/DNM3/ADCY9/ADCY6/FXYD2	0.609505462822711
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	44/2485	155/9376	1.07105601350036	CREB5/CDKN1A/TCF7L1/PLCB4/CAMK2D/ADCY4/PDE8A/BRAF/RAP1B/KMT2A/GSK3B/CREB1/CCND1/MAPK1/NR4A1/RAP1A/PLCB1/AHR/MAPK3/ATF2/APC/FZD6/USP8/TCF7L2/CDKN2C/GNAS/PBX1/RASD1/ADCY9/LDLR/CAMK2G/KMT2D/WNT2B/E2F3/WNT5A/RBBP5/ADCY6/WNT9A/ITPR3/AXIN1/CDK2/TCF7/WDR5/CACNA1C	0.53565527512501
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/2485	18/9376	1.25767940979209	ACSL3/ACACA/ACSL4/ACSL5/ACACB/MECR	0.657101046688262
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	6/2485	18/9376	1.25767940979209	PRDX1/MTR/LMBRD1/ABCD4/HCFC1/MMAB	0.657101046688262
Organismal Systems	Digestive system	hsa04978	Mineral absorption	18/2485	61/9376	1.11335554309463	MT1E/MT1X/MT2A/ATP2B4/MT1G/MT1M/ATP2B1/ATP1A1/TRPM7/HMOX2/ATP1B3/SLC30A1/HMOX1/MT1A/MT1F/HEPH/FXYD2/MT1H	0.533364319961436
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	24/2485	83/9376	1.0909990060847	POLR2L/POLR1D/NFKB1/RIPK1/NFKBIA/ADAR/POLR2H/TBK1/POLR3GL/IKBKB/GSDMD/IRF3/RELA/CASP7/NFKBIB/CASP3/DNASE2/MLKL/POLR1C/POLR3D/IRF7/POLR3A/POLR3B/POLR3F	0.500040794171356
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	30/2485	105/9376	1.07801092267893	LMNA/SNTB2/ITGAV/ITGA9/TPM4/ADCY4/ITGA1/TPM2/DES/ITGA5/TGFB2/ITGA6/TPM3/ATP2A2/ITGB1/GNAS/TTN/ITGB4/SGCE/ADCY9/EMD/SGCD/ACTG1/ADCY6/ITGB3/CACNB2/TGFB3/ITGA8/CACNA1C/DMD	0.482719100259779
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	43/2485	154/9376	1.05351067443623	AKT3/CREB5/PLCB4/CAMK2D/TPM4/ADCY4/TPM2/PPP2CB/ATP2B4/ATP2B1/PPP2R5C/ATP1A1/CREB1/MAPK1/PPP2R5E/TPM3/ATP2A2/PLCB1/PPP2R3C/MAPK3/ATF2/ATP1B3/PPP2CA/PPP2R1B/PPP2R2D/PPP2R5A/PPP1CC/GNAS/MAPK14/PPP2R3A/RAPGEF4/BCL2/ADCY9/CAMK2G/AKT1/CALML4/PPP2R5D/ADCY6/CACNB2/PPP2R5B/SLC9A1/CACNA1C/FXYD2	0.402064691580663
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	13/2485	44/9376	1.11476129504299	HLA-C/HLA-A/HLA-B/HSPD1/HLA-E/HLA-F/ICA1/HLA-DPB1/HLA-DRB1/PTPRN2/HLA-DPA1/HLA-DQB1/HLA-DQA1	0.45818632532534
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	6/2485	19/9376	1.19148575664513	GUSB/IDS/HGSNAT/NAGLU/HYAL1/HPSE	0.501709899884625
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	6/2485	19/9376	1.19148575664513	DLST/BCKDHB/PDHA1/BCKDHA/DHTKD1/LIAS	0.501709899884625
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	46/2485	166/9376	1.04554071416451	AKT3/CREB5/ROCK2/PPP3CA/PRKG1/PLCB4/PDE2A/ADCY4/NFATC1/PPP3CC/ATP2B4/EDNRB/SLC25A6/PRKCE/MYL9/NFATC2/ATP2B1/ATP1A1/CREB1/ROCK1/MAPK1/ATP2A2/PLCB1/MAPK3/ATF2/ATP1B3/VDAC1/RAF1/INSR/NFATC3/GNA12/MEF2A/PPP3R1/PPP3CB/PPP1CC/MEF2D/ADCY9/NPR1/AKT1/CALML4/ADCY6/ITPR3/KCNMB3/PPIF/CACNA1C/FXYD2	0.355493591091574
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	4/2485	12/9376	1.25767940979209	NPC1/ASGR1/NCAM1/CLEC4M	0.536348842076888
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	7/2485	23/9376	1.14831598285364	LARGE1/CRPPA/B3GALNT2/ST3GAL3/RXYLT1/B4GALT3/B4GALT2	0.427645705071566
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	12/2485	42/9376	1.07801092267893	MAP1LC3A/SAT2/SLC39A14/MAP1LC3B/ACSL3/ACSL4/ATG5/ACSL5/LPCAT3/GSS/HMOX1/GCLC	0.304266312574737
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/2485	20/9376	1.13191146881288	LBR/EBP/CYP51A1/SOAT1/HSD17B7/LSS	0.354617494641005
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	18/2485	65/9376	1.04484135582727	AKT3/PLCB4/KCNN3/ARRB1/MAPK1/PLCB1/KRAS/MAPK3/RAF1/GABBR1/HRAS/PIK3CA/PIK3R3/PIK3CB/AKT1/NRAS/ITPR3/CACNA1C	0.217843677692018
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	8/2485	28/9376	1.07801092267893	PCBD1/GPHN/AKR1C3/PTS/GCH1/FPGS/PCBD2/SPR	0.248246302237036
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/2485	17/9376	1.10971712628713	CYP46A1/HSD3B7/CYP27A1/CYP39A1/CYP7B1	0.271889146162306
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	5/2485	17/9376	1.10971712628713	MTR/TXNRD1/TXNRD2/SEPHS1/SCLY	0.271889146162306
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	40/2485	149/9376	1.01289616896007	GNG12/PLCB4/ADCY4/NDUFS7/MGLL/NDUFB8/NDUFC1/GNB1/NDUFB2/NDUFB11/NDUFB1/NDUFA11/NDUFB7/NDUFB10/MAPK1/NDUFS4/PLCB1/MAPK8/MAPK3/NDUFA6/GNB4/GNG5/NDUFS8/NDUFA10/NDUFV1/GNG11/NDUFA4/NDUFA8/GNB5/NDUFV3/NDUFA9/NDUFS2/MAPK14/GABRE/ADCY9/DAGLB/ADCY6/GRIA1/ITPR3/CACNA1C	0.0952864831254216
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/2485	21/9376	1.07801092267893	ALDH2/BCAT1/PANK3/ALDH3A2/PPCDC/BCAT2	0.214907155450193
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	21/2485	78/9376	1.01581798483207	MARCKSL1/JAK1/TGFB2/NFKB1/MAPK1/NFKBIA/MAPK3/ITGB1/HLA-DPB1/HLA-DRB1/STAT1/RELA/TAB2/MAPK14/HLA-DPA1/NFKBIB/HLA-DQB1/IRAK4/TRAF6/TGFB3/HLA-DQA1	0.0842386493566604
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	26/2485	97/9376	1.01132983467817	GNG12/PRKG1/PLCB4/CAMK2D/ADCY4/GNB1/CREB1/MAPK1/PLCB1/MAPK3/GNB4/GNG5/PER1/GNG11/GNB5/GNAS/PER3/RASD1/ADCY9/CAMK2G/CALML4/ADCY6/GRIA1/GRIN2B/ITPR3/CACNA1C	0.0673544915964349
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	17/2485	63/9376	1.01812142697455	CDKN1A/TCF7L1/BMP2/POLK/GSK3B/APC/FZD6/TCF7L2/GADD45A/GADD45B/DDB2/WNT2B/WNT5A/GADD45G/WNT9A/AXIN1/TCF7	0.0866613751749451
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	27/2485	101/9376	1.00863398211048	TCF7L1/PLCB4/CAMK2D/ADCY4/EDNRB/GSK3B/CREB1/MAPK1/CREBBP/PLCB1/KRAS/MAPK3/FZD6/RAF1/TCF7L2/HRAS/GNAS/MITF/ADCY9/CAMK2G/NRAS/CALML4/WNT2B/WNT5A/ADCY6/WNT9A/TCF7	0.0523868857907677
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	13/2485	48/9376	1.02186452045607	AKT3/PLCB4/HK1/ATP1A1/PLCB1/ATP1B3/PIK3CA/PIK3R3/PIK3CB/G6PC3/AKT1/GNAT3/FXYD2	0.0911956275823452
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/2485	10/9376	1.13191146881288	SQOR/MPST/TST	0.250618536297097
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	18/2485	67/9376	1.01365206162347	PKM/TPI1/HK1/ENO1/LDHA/AKR1A1/ALDH9A1/ALDH2/GAPDH/PFKL/GPI/PFKP/PGM1/G6PC3/ALDH3A2/PDHA1/ACSS2/PGM2	0.0673429033137807
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	29/2485	109/9376	1.00383585919185	AKT3/JAK1/NFKB1/MAPK1/RIPK1/NFKBIA/MAPK8/TBK1/MAPK3/MAP2K4/TRAF3/IKBKB/RAC1/IRF3/PIK3CA/STAT1/RELA/TAB2/MAPK14/MAP2K3/PIK3R3/IRF9/PIK3CB/IRAK4/AKT1/TRAF6/TICAM1/TYK2/IRF7	0.0241887838547811
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	8/2485	30/9376	1.00614352783367	NFKB1/MTR/IKBKB/GART/RELA/ABCC1/FPGS/ATIC	0.020238265034593
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	27/2485	103/9376	0.989048856244262	HSPB1/LAMA4/ACTN1/PLCB4/LAMB2/PTK2/TGFB2/RAB7A/PRDX1/NFKB1/RAB5A/PLCB1/SERPINB9/VCL/LAMB1/LAMC1/GNA14/GNAS/COL4A5/PIK3CA/RELA/PIK3R3/PIK3CB/CASP3/ARG2/CXCL1/TGFB3	-0.0671082126789555
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	18/2485	69/9376	0.98427084244598	CREB5/PPP3CA/CAMK2D/PPP3CC/CREB1/ATF2/HDAC1/PPP3R1/PPP3CB/PPP1CC/GNAS/HDAC2/CAMK2G/CALML4/GRIA1/GRIN2B/CACNA1C/MAOB	-0.0787467902547872
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	13/2485	50/9376	0.980989939637827	SAT2/P4HA3/ODC1/ALDH9A1/P4HA1/ALDH2/OAT/AZIN2/ALDH3A2/GOT2/ARG2/CKB/MAOB	-0.0809335335868745
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	4/2485	15/9376	1.00614352783367	AK2/AK1/NTPCR/AK4	0.0142991442350839
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	30/2485	116/9376	0.975785748976618	SLC38A1/GNG12/PPP3CA/PLCB4/HOMER3/ADCY4/GLS/PPP3CC/GNB1/PLA2G4C/PLD1/SHANK3/MAPK1/PLCB1/MAPK3/GNB4/GNG5/SLC38A2/GNG11/HOMER1/PPP3R1/PPP3CB/GNB5/GNAS/ADCY9/ADCY6/GRIA1/GRIN2B/ITPR3/CACNA1C	-0.157580419166991
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/2485	27/9376	0.978195096504956	ELOVL5/ELOVL1/TECR/HACD2/ACAA1/HACD1/ACOX3	-0.0681335755796734
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	8/2485	31/9376	0.973687285000325	HADHA/ALDH9A1/ALDH2/ECHS1/HIBCH/ACADS/ALDH3A2/ACOX3	-0.0881179866385528
Human Diseases	Immune disease	hsa05330	Allograft rejection	10/2485	39/9376	0.967445699840066	HLA-C/HLA-A/HLA-B/HLA-E/HLA-F/HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DQB1/HLA-DQA1	-0.122333301739474
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	21/2485	82/9376	0.966265888010993	MGST2/MGST3/GSTO1/GUSB/NME2/NME1/NME3/GMPS/CMPK1/NME7/UPP1/UCK2/TK2/IMPDH1/GSTM3/UCKL1/CDADC1/RRM2B/RRM1/GSTT2B/MGST1	-0.184239431233617
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	22/2485	86/9376	0.965195826119508	CREB5/PLCB4/CAMK2D/ADCY4/KCNN3/VAMP2/ATP1A1/PCLO/CREB1/PLCB1/ATF2/ATP1B3/GNAS/RAPGEF4/ADCY9/CAMK2G/ADCY6/ITPR3/KCNMB3/TRPM4/CACNA1C/FXYD2	-0.19470648119067
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	56/2485	217/9376	0.973687285000325	RPS6KA2/AKT3/CREB5/HSP90AA1/ADCY4/MGST2/STAT3/PTGES3/RPS6KA3/MGST3/GSTO1/EPHX1/KPNB1/HSP90AB1/KPNA4/ARRB1/MYC/CREB1/CCND1/NFKB1/MAPK1/KPNA3/KRAS/AHR/STAT5B/MAPK3/ATF2/CCND3/RAF1/SOS2/XIAP/KPNA1/HRAS/GNAS/PIK3CA/RELA/RPS6KB1/PIK3R3/DLL4/HSP90B1/BCL2/PIK3CB/ADCY9/KPNA5/AKT1/NRAS/RXRA/GSTM3/BCL6/ADCY6/STAT5A/PPARA/GSTT2B/VEGFA/MGST1/CACNA1C	-0.235493654311113
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	15/2485	59/9376	0.95924700746854	MGST2/MGST3/GSTO1/GSTK1/TXNDC12/ODC1/GGCT/GGT5/GSS/GSTM3/GCLC/RRM2B/RRM1/GSTT2B/MGST1	-0.188562432807619
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	15/2485	59/9376	0.95924700746854	AKT3/PRKG1/ADCY4/PNPLA2/MGLL/FABP4/INSR/GNAS/PIK3CA/PIK3R3/PIK3CB/ADCY9/NPR1/AKT1/ADCY6	-0.188562432807619
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	19/2485	75/9376	0.955836351441985	PKM/TPI1/ENO1/MAT2A/MTR/TALDO1/ASL/GAPDH/IDH3B/PFKL/BCAT1/ACO1/PFKP/ACO2/GOT2/IDH3A/ARG2/PRPS2/BCAT2	-0.230588935548402
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	19/2485	75/9376	0.955836351441985	CREB5/PLCB4/ADCY4/HSPA5/ATP1A1/CREB1/PLCB1/ATF2/ATP1B3/TTF1/ASGR1/GNAS/SLC26A4/HSP90B1/ADCY9/ADCY6/ITPR3/FXYD2/TTF2	-0.230588935548402
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	43/2485	168/9376	0.965718118233209	AKT3/JAK1/CDKN1A/IL7/FHL1/STAT3/MCL1/PIAS1/SOCS2/MYC/PTPN11/CCND1/CREBBP/STAT5B/PDGFA/CCND3/RAF1/SOS2/GHR/HRAS/PIK3CA/STAT1/SOCS6/PIK3R3/PIAS2/BCL2/IRF9/PIK3CB/STAM2/AKT1/IL15RA/IL15/SOCS4/SOCS5/STAM/LIF/CSF3/STAT5A/IL6R/TYK2/PIAS3/CLCF1/SOCS1	-0.269242954817795
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	58/2485	226/9376	0.968301846477093	VAV3/AKT3/CREB5/PLCE1/AFDN/ROCK2/CAMK2D/ADCY4/BRAF/RAP1B/NFATC1/ATP2B4/MYL9/ATP2B1/PLD1/ARAP3/ATP1A1/PDE4B/CREB1/ROCK1/NFKB1/MAPK1/NFKBIA/CREBBP/RAP1A/ATP2A2/MAPK8/MAPK3/ATP1B3/RRAS2/RAF1/RRAS/GABBR1/F2R/PDE4D/PPP1CC/RAC1/GNAS/PIK3CA/RELA/RAPGEF4/PIK3R3/PIK3CB/ADCY9/NPR1/CAMK2G/AKT1/CALML4/ADCY6/SLC9A1/PPARA/GRIA1/GRIN2B/ACOX3/CACNA1C/FXYD2/OXTR/PDE4A	-0.289657879358447
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	22/2485	87/9376	0.954101621221582	TPM4/COX7A1/COX6A1/TPM2/COX7A2/COX5A/ASPH/ATP1A1/COX7A2L/COX5B/TPM3/ATP2A2/COX6B1/ATP1B3/CYC1/UQCR11/COX6C/COX4I1/CACNB2/SLC9A1/CACNA1C/FXYD2	-0.258273709561928
NA	NA	hsa04519	Cadherin signaling	104/2485	404/9376	0.971277167958244	MYO1D/FLT4/ACTN1/VAV3/WWTR1/SCN3B/AFDN/ROCK2/TCF7L1/JUP/CTNND1/CTNNA1/ADAM10/YWHAH/ERBIN/DES/YWHAB/DAAM1/YWHAG/YWHAQ/LHFPL6/DSP/LATS2/PTK2/TJP1/NCKAP1/YAP1/CDH13/BRK1/ARPC5L/GSK3B/RERE/TEAD1/RYK/MYO1B/TAOK1/ANKRD6/MPDZ/IGF1R/GJA1/ROCK1/NFKB1/MAPK1/STK3/NFKBIA/MYO1E/CREBBP/VIM/FGFR1/MAPK8/ARPC4/KRAS/MAPK3/VCL/YWHAZ/RRAS2/ARPC1A/APC/FZD6/RAF1/TCF7L2/RRAS/SHOC2/CELSR1/LRP5/TEAD4/AMOTL1/PSENEN/IKBKB/PPP1CC/RAC1/APH1B/HRAS/ABI2/PSEN1/RELA/MAPK14/TEAD2/MAP2K3/GABRE/ARHGAP35/LHFPL2/DCHS1/LIMD1/FAT4/NF2/NRAS/WNT2B/CDH22/PCDH9/WASF1/MOB1B/WNT5A/MRAS/ACTG1/VANGL1/PCDH7/WNT9A/MET/PSEN2/WTIP/AXIN1/TCF7/ACTR3B	-0.354389640844622
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	29/2485	115/9376	0.951461814364447	GNG12/AKT3/CREB5/PLCB4/CAMK2D/ADCY4/FYN/GNB1/CREB1/MAPK1/PLCB1/KRAS/MAPK3/GNB4/GNG5/GNG11/GNB5/HRAS/PIK3CA/PIK3R3/BCL2/PIK3CB/ADCY9/CAMK2G/AKT1/NRAS/ADCY6/ITPR3/CACNA1C	-0.314493175837137
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	33/2485	133/9376	0.936167380221177	VAV3/SHC1/HLA-C/HLA-A/PPP3CA/HLA-B/BRAF/FYN/NFATC1/PPP3CC/HLA-E/NFATC2/TNFRSF10B/PLCG2/PTPN11/MAPK1/KRAS/MAPK3/RAF1/SOS2/PPP3R1/PPP3CB/RAC1/HRAS/PIK3CA/BID/PIK3R3/SHC2/PIK3CB/CASP3/PLCG1/NRAS/ARAF	-0.445214932959022
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	13/2485	54/9376	0.908324018183173	REV3L/HES1/POLK/FANCC/REV1/ERCC1/ATR/WDR48/MLH1/TOP3A/PMS2/POLH/RMI1	-0.405700562813763
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	10/2485	42/9376	0.898342435565776	HADHA/ACAT1/ALDH9A1/ALDH2/ECHS1/DLST/ALDH3A2/ACAT2/DHTKD1/MAOB	-0.396495403637677
Human Diseases	Substance dependence	hsa05032	Morphine addiction	22/2485	91/9376	0.912163088420634	GNG12/PDE7B/PDE2A/ADCY4/PDE8A/GRK5/GNB1/ARRB1/PDE4B/PDE1A/GNB4/GNG5/GNG11/GABBR1/PDE4D/GNB5/GNAS/GABRE/ADCY9/PDE7A/ADCY6/PDE4A	-0.505608666091615
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	24/2485	99/9376	0.914675934394244	PRKCH/PLCB4/CAMK2D/ADCY4/PRKCE/PLA2G4C/PLCG2/PLCB1/MAPK8/PPP1CC/GNAS/PIK3CA/MAPK14/MAP2K3/PIK3R3/PIK3CB/ADCY9/PLCG1/CAMK2G/PLA2G6/CALML4/PRKCQ/ADCY6/ITPR3	-0.512499055957925
Genetic Information Processing	Translation	hsa03010	Ribosome	55/2485	222/9376	0.934761723494118	RPS26/MRPL18/MRPS21/RPS27L/MRPL52/MRPS6/MRPS24/MRPS15/MRPS5/MRPL41/MRPL43/DAP3/MRPL47/MRPL34/MRPS18C/MRPL55/RPS28/MRPL22/MRPL21/MRPS12/MRPL37/MRPS31/MRPL16/MRPL15/MRPL11/MRPS11/RPSA/MRPS10/MRPS27/MRPL28/MRPS17/RPS15A/MRPL19/MRPS14/RPS19/RPL35A/MRPS26/MRPS25/RPL10/MRPS35/RPS5/MRPS9/RPL22/MRPS18A/RPS8/RPL30/MRPS2/RPL6/RPL8/MRPL48/MRPL45/RPL34/MRPL10/RPS3/RPS27A	-0.590719383946222
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	8/2485	35/9376	0.862408738143145	ENOSF1/TPI1/GMDS/HK1/PFKFB3/PFKL/PFKP/PMM2	-0.489706534914588
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/2485	31/9376	0.851976374375284	TALDO1/PFKL/GPI/PFKP/PGM1/PGM2/PRPS2	-0.495712580976527
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/2485	27/9376	0.838452939861391	HADHA/ACAT1/ECHS1/ACADS/OXCT1/ACAT2	-0.504784569861982
NA	NA	hsa03272	Virion - Hepatitis viruses	11/2485	48/9376	0.864654594232059	CD9/CLDN5/PDCD6IP/HSPG2/CHMP4B/CHMP4A/TSG101/CD81/CD63/CHMP1B/LDLR	-0.564517719206051
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/2485	23/9376	0.820225702038317	GLS/ASL/GLUD1/GOT2/ARG2	-0.518350786788998
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/2485	23/9376	0.820225702038317	GLS/ATP1A1/ATP1B3/GLUD1/FXYD2	-0.518350786788998
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	15/2485	65/9376	0.870701129856059	CREB5/PLCB4/ADCY4/PDE8A/CREB1/NR4A1/PLCB1/ATF2/GNAS/PBX1/ADCY9/LDLR/ADCY6/ITPR3/CACNA1C	-0.628146515062512
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	10/2485	45/9376	0.838452939861391	HLA-C/HLA-A/HLA-B/HLA-E/HLA-F/HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DQB1/HLA-DQA1	-0.652302331803804
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	15/2485	66/9376	0.857508688494604	RORA/STAT3/NFATC1/TGFB2/SMAD2/NFKB1/HLA-DPB1/HLA-DRB1/STAT1/RELA/HLA-DPA1/SMAD3/HLA-DQB1/TGFB3/HLA-DQA1	-0.697578715325713
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/2485	24/9376	0.786049631120054	EXT1/B3GAT3/NDST1/HS3ST1/B4GALT7	-0.630193792739015
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	11/2485	51/9376	0.813792559277232	PAFAH1B1/PLPP1/PLA2G4C/PLD1/PAFAH1B2/SELENOI/CHPT1/PLA2G6/PAFAH2/PLA2G12A/PLPP2	-0.800691851313805
Organismal Systems	Digestive system	hsa04970	Salivary secretion	21/2485	93/9376	0.851976374375284	PRKG1/PLCB4/ADCY4/ATP2B4/ATP2B1/VAMP2/ATP1A1/PLCB1/ATP1B3/GNAS/CST3/ADCY9/PRH1/SLC12A2/CD38/CALML4/ADCY6/SLC9A1/BST1/ITPR3/FXYD2	-0.861461843750805
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/2485	16/9376	0.707444668008048	MIF/GOT2/MAOB	-0.703295428607823
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	20/2485	89/9376	0.847873759410395	SLC38A1/GNG12/ADCY4/GABARAPL2/GLS/GNB1/GABARAPL1/GPHN/GNB4/GNG5/SLC38A2/GNG11/GABBR1/GNB5/GABARAP/GABRE/ADCY9/NSF/ADCY6/CACNA1C	-0.865902758651014
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	9/2485	43/9376	0.789705675915961	PLPP1/ACAT1/GOT2/PLA2G12A/SLC27A4/ACAT2/AGPAT2/PLPP2/SLC27A1	-0.829963236801761
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	23/2485	102/9376	0.85078313015347	RAB11A/PLCB4/ADCY4/RAP1B/ATP2B4/ATP2B1/ATP1A1/RAP1A/ATP2A2/PLCB1/ATP1B3/RAB8A/RAC1/GNAS/ADCY9/SLC12A2/CD38/PLA2G12A/ADCY6/SLC9A1/BST1/ITPR3/FXYD2	-0.909896878924797
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/2485	26/9376	0.72558427488005	PLA2G4C/ACAA1/PLA2G6/PLA2G12A/ACOX3	-0.84139043940887
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/2485	26/9376	0.72558427488005	BTD/LMBRD1/ABCD4/ABCC1/CUBN	-0.84139043940887
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	6/2485	31/9376	0.730265463750243	GUSB/AKR1A1/ALDH9A1/ALDH2/UGDH/ALDH3A2	-0.903307175314501
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/2485	22/9376	0.686006950795683	ALDH9A1/ALDH2/ALDH3A2/MAOB	-0.885401802335821
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	17/2485	79/9376	0.811919618979701	AP2B1/AP2M1/VAMP2/AP2A2/STX2/STX3/ATP6V1D/SYT1/STXBP1/NAPA/AP2A1/DNM3/ATP6V1H/UNC13B/NSF/ATP6V0A2/TCIRG1	-1.00807614059491
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	7/2485	36/9376	0.733646322378717	GUSB/AKR1A1/UGP2/UGDH/CRPPA/FGGY/DCXR	-0.961488777762208
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	9/2485	45/9376	0.754607645875252	ABCG1/ABCA5/ABCA4/ABCD4/ABCC1/ABCA6/ABCA3/TAP2/ABCB10	-0.990856810795914
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	3/2485	18/9376	0.628839704896043	GBA2/MAN2C1/AGA	-0.946485474329214
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	9/2485	46/9376	0.738203131834485	GUSB/HMOX2/HMOX1/UROS/ALAS1/HCCS/HEPH/MMAB/PPOX	-1.06883397582505
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	7/2485	37/9376	0.713818043395508	GLS/ASL/GLUD1/RIMKLB/GOT2/ADSL/GFPT2	-1.04737121193065
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/2485	69/9376	0.765543988569096	PPP3CA/PLCB4/PPP3CC/CREB1/PDE1A/PLCB1/PPP3R1/PPP3CB/GNAS/NPR1/CALML4/ADCY6/ITPR3/CACNA1C	-1.17378558214042
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	10/2485	52/9376	0.72558427488005	ADCY4/PLA2G4C/IGF1R/AKR1C3/INSR/GNAS/ADCY9/LDLR/ADCY6/HSD17B7	-1.19156364350168
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/2485	39/9376	0.677211989888046	MTHFD1L/MAT2A/MTR/GART/AHCYL2/BHMT2/ATIC	-1.21298024669286
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	18/2485	88/9376	0.771757819645144	TFPI/CD59/CLU/F8/SERPING1/CD55/VWF/CFI/THBD/PROCR/PLAT/F2R/C1R/SERPINE1/PROS1/C1S/CFH/F2RL3	-1.29176600120378
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	54/2485	238/9376	0.856067497421504	JAK1/RPS26/STAT3/VWF/RPS27L/PLCG2/NFKB1/MAPK1/NFKBIA/ADAR/MAPK8/TBK1/MAPK3/ADAM17/ISG15/EIF2AK2/TRAF3/IKBKB/C1R/IRF3/RPS28/PIK3CA/STAT1/RELA/TAB2/MAPK14/C1S/PIK3R3/IRF9/PIK3CB/NFKBIB/RPSA/OAS1/RPS15A/PLCG1/IRAK4/RPS19/RPL35A/RPL10/TRAF6/RPS5/MX1/RPL22/RPS8/CSF3/RPL30/IL6R/RPL6/TYK2/RPL8/RPL34/MX2/RPS3/RPS27A	-1.35060852937988
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	9/2485	49/9376	0.69300702172217	CREB5/CREB1/NFKB1/ATF2/GNAS/RELA/GPSM1/GRIN2B/MAOB	-1.29378825280799
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	24/2485	115/9376	0.787416673956784	APP/GNG12/PLCB4/BRAF/GNB1/PLA2G4C/MAPK1/PLCB1/KRAS/MAPK3/GNB4/GNG5/RAF1/GNG11/GNB5/HRAS/GNAS/CYP4X1/CASP3/NRAS/ARAF/ITPR3/CACNA1C/MAOB	-1.37738987277643
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	10/2485	54/9376	0.698710783217825	HLA-C/HLA-A/HLA-B/HLA-E/HLA-F/HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DQB1/HLA-DQA1	-1.33331765197207
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	40/2485	183/9376	0.824707809699728	REXO2/NOP10/SNU13/XRN2/NOP58/EIF6/NHP2/XRN1/CSNK2A1/CSNK2B/XPO1/CSNK2A2/WDR43/NXT1/GNL3/GTPBP4/IMP3/HEATR1/BMS1/GNL2/WDR75/NMD3/MDN1/GNL3L/IMP4/POP5/RBM28/UTP6/MPHOSPH10/FCF1/LSG1/RPP38/RIOK1/DROSHA/UTP18/UTP4/RIOK2/REXO1/NAT10/EFL1	-1.43802750296979
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	9/2485	50/9376	0.679146881287726	HLA-DPB1/LTBR/HLA-DRB1/HLA-DPA1/HLA-DQB1/MAP3K14/IL15RA/IL15/HLA-DQA1	-1.36600179931174
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/2485	50/9376	0.679146881287726	GYPC/TGFB2/THBS1/CD81/ACKR1/CSF3/TGFB3/MET/THBS3	-1.36600179931174
Human Diseases	Immune disease	hsa05310	Asthma	5/2485	32/9376	0.58953722334004	HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DQB1/HLA-DQA1	-1.39665796595426
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	4/2485	28/9376	0.539005461339465	ATP6V1D/SLC12A7/ATP6V0A2/TCIRG1	-1.46697649052233
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/2485	17/9376	0.443886850514854	GLUD1/CA5B	-1.37809961397865
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	14/2485	76/9376	0.695033358042995	PLCB4/CAMK2D/ADCY4/ATP1A1/PLCB1/ATP1B3/GNAS/ADCY9/CAMK2G/CALML4/ACTG1/ADCY6/SLC9A1/ITPR3	-1.60296990710294
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/2485	23/9376	0.49213542122299	LNPEP/CTSA/NLN	-1.46434727864956
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	71/2485	323/9376	0.82936753648828	EFNA5/SHC1/SLC7A1/ZEB1/ZFPM2/TNXB/CDKN1A/SOX4/STAT3/FOXP1/RECK/STMN1/MCL1/GLS/RDX/ITGA5/FSCN1/TGFB2/PRKCE/THBS1/EFNA1/PLCG2/MYC/CCND1/ROCK1/NFKB1/MAPK1/CREBBP/VIM/UBE2I/KRAS/MAPK3/PDGFA/MARCKS/RASSF1/APC/HDAC1/HDAC4/RAF1/SOS2/IKBKB/HRAS/MDM4/NOTCH1/ABL1/PIK3CA/MMP16/HDAC2/BCL2L11/PIK3R3/MDM2/BCL2/PIK3CB/ABCC1/CASP3/PLCG1/HMOX1/HOXD10/DDIT4/NRAS/EZH2/E2F3/MAPK7/SLC45A3/TNC/TP63/ITGB3/MET/VEGFA/SPRY2/SOCS1	-1.87402064832756
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	32/2485	160/9376	0.754607645875252	CLDN5/ITGAV/CD99/HLA-C/HLA-A/ITGA9/HLA-B/NECTIN3/NRXN3/PTPRM/HLA-E/F11R/NECTIN2/HLA-F/ITGA6/GLG1/SDC4/PVR/SDC3/ITGB1/HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DQB1/NCAM1/NLGN4X/CD99L2/CXADR/NEO1/CD274/ITGA8/HLA-DQA1	-1.87999846655364
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	54/2485	254/9376	0.802141985772905	FLT4/PLCE1/PPP3CA/PLCB4/CAMK2D/ADCY4/SPHK1/MCU/NFATC1/PPP3CC/ATP2B4/EDNRB/SLC25A6/NFATC2/ATP2B1/ASPH/PLCG2/ITPKC/PDE1A/ATP2A2/FGFR1/PLCB1/STIM2/PDGFA/VDAC1/ITPKB/P2RX4/STIM1/NFATC3/F2R/GNA14/PPP3R1/PPP3CB/GNAS/CAMK1/PDGFD/ADCY9/TPCN1/PLCG1/ORAI3/CAMK2G/CD38/CALML4/RET/ORAI2/TFEB/MET/VEGFA/GRIN2B/ITPR3/PPIF/CACNA1C/OXTR/ERBB4	-1.91969918347166
NA	NA	hsa04981	Folate transport and metabolism	4/2485	31/9376	0.486843642500162	MTR/ABCC1/BHMT2/FPGS	-1.71849636399045
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/2485	52/9376	0.58046741990404	LRPAP1/VDAC1/NPC1/OSBPL5/VAPB/LDLR/CYP27A1/SOAT1	-1.82168776766816
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	3/2485	26/9376	0.43535056492803	HES1/NR5A2/HHEX	-1.73128065485135
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	16/2485	95/9376	0.635459070210738	TGFB2/ATP6V1D/HLA-DPB1/TNFRSF11A/HLA-DRB1/HLA-DPA1/HLA-DQB1/CSF1/ATP6V1H/IL15/ATP6V0A2/TCIRG1/CXCL1/TGFB3/VEGFA/HLA-DQA1	-2.1444623363218
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	17/2485	100/9376	0.641416498993964	CD9/CD59/IL7/ITGA1/CD55/ITGA5/ITGA6/HLA-DPB1/HLA-DRB1/HLA-DPA1/HLA-DQB1/CSF1/CD38/CSF3/ITGB3/IL6R/HLA-DQA1	-2.16479932034807
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/2485	29/9376	0.390314299590647	SLC24A1/GNB1/CALML4	-1.97458846912597
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/2485	30/9376	0.377303822937626	PLA2G4C/PLA2G6/PLA2G12A	-2.05131165815694
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	9/2485	63/9376	0.539005461339465	PTGES3/PLA2G4C/AKR1C3/GGT5/PTGES2/PLA2G6/PRXL2B/PLA2G12A/LTA4H	-2.20459573766336
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/2485	17/9376	0.221943425257427	GGT5	-1.92809586735897
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/2485	37/9376	0.407896024797433	MIF/GOT2/FAHD1/MAOB	-2.1669872743023
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	4/2485	38/9376	0.397161918881711	RFXANK/ADA/TAP2/DCLRE1C	-2.23600748011579
Human Diseases	Substance dependence	hsa05034	Alcoholism	34/2485	191/9376	0.671640313082685	SHC1/GNG12/CREB5/BRAF/CAMKK2/GNB1/HDAC7/CREB1/MAPK1/KRAS/MAPK3/ATF2/GNB4/HDAC1/GNG5/HDAC4/RAF1/SOS2/HDAC8/GNG11/PPP1CC/GNB5/HRAS/GNAS/HDAC2/SHC2/HAT1/HDAC3/NRAS/CALML4/ARAF/GRIN2B/PKIA/MAOB	-2.7531802532567
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/2485	37/9376	0.305922018598075	LAMA4/PLCB4/PLCB1	-2.54019262842618
Organismal Systems	Digestive system	hsa04976	Bile secretion	12/2485	90/9376	0.503071763916834	ADCY4/EPHX1/ATP1A1/ATP1B3/GNAS/ADCY9/LDLR/RXRA/ADCY6/SLC9A1/HMGCR/FXYD2	-2.84451546605073
Organismal Systems	Sensory system	hsa04742	Taste transduction	11/2485	86/9376	0.482597913059754	SCN3A/PLCB4/ADCY4/SCNN1B/PDE1A/PLCB1/GABBR1/GNAT3/ADCY6/ITPR3/CACNA1C	-2.89452466404641
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	8/2485	70/9376	0.431204369071572	MGST2/MGST3/GSTO1/EPHX1/GSTK1/GSTM3/GSTT2B/MGST1	-2.86834546956887
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	33/2485	195/9376	0.638514161894444	AKT3/PLCB4/VWF/CASP4/SLC25A6/PLCG2/HDAC7/NFKB1/MAPK1/CLCN3/PLCB1/MAPK3/VDAC1/HDAC1/HDAC4/RAF1/HDAC8/GSDMD/RAC1/PIK3CA/HMGB1/RELA/MAPK14/HDAC2/PIK3R3/HAT1/PIK3CB/HDAC3/PLCG1/AKT1/ACTG1/ITGB3/PPIF	-3.06317147720561
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/2485	41/9376	0.276075968003141	GABRE/GRIA1/GRIN2B	-2.78955848466745
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	8/2485	73/9376	0.41348364157548	MGST2/MGST3/GSTO1/GSTK1/GSTM3/GSTT2B/MGST1/MAOB	-3.02090980520974
NA	NA	hsa04081	Hormone signaling	36/2485	219/9376	0.62022546236322	SMAD1/GNG12/ITGAV/PRKG1/PLCB4/ADCY4/STAT3/GNB1/IGF1R/PLCB1/STAT5B/GNB4/SMAD4/GNG5/GNG11/SMAD9/INSR/GNA12/GNA14/GHR/GNB5/GNAS/PIK3CA/RAPGEF4/PIK3R3/RAMP1/PIK3CB/ADCY9/NPR1/RAMP3/ACVR1/ADCY6/ITGB3/STAT5A/HEPH/OXTR	-3.41490796692991
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	8/2485	79/9376	0.38207982069633	MGST2/MGST3/GSTO1/EPHX1/GSTK1/GSTM3/GSTT2B/MGST1	-3.31193815202305
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/2485	41/9376	0.184050645335427	ALAS1/MAOB	-3.14416754349904
NA	NA	hsa04382	Cornified envelope formation	34/2485	217/9376	0.591167280178768	CLDN5/S100A10/S100A16/DST/JUP/S100A13/PCSK6/DSP/PPP2CB/TJP1/UGCG/PPP2R5C/ITGA6/PLEC/ELOVL1/PPP2R5E/PPP2R3C/PPP2CA/PPP2R1B/KDSR/PPP2R2D/PPP2R5A/SPTLC1/COL4A5/ITGB4/PPP2R3A/CAPN1/GBA2/PPP2R5D/SLC27A4/PPP2R5B/S100A6/SLC27A1/PPL	-3.65897290317022
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	11/2485	100/9376	0.415034205231388	CCL21/CCL14/TNFRSF10B/TNFRSF10D/TNFRSF14/LTBR/ACKR3/CSF1/IL6R/CXCL1/TNFRSF10C	-3.5314886250738
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/2485	66/9376	0.285836229498201	AKR1C3/SRD5A3/HSD17B7/CYP7B1/DHRS11	-3.49625138750966
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	9/2485	99/9376	0.343003475397842	CFI/C1R/HLA-DPB1/HLA-DRB1/C1S/CFH/HLA-DPA1/HLA-DQB1/HLA-DQA1	-3.9462500554302
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/2485	68/9376	0.221943425257427	ALDH1A1/RDH11/DHRS4L2/RETSAT	-3.86674164464842
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/2485	103/9376	0.329682952081421	COL18A1/ATP1A1/ATP1B3/SLC38A2/COL5A2/ELN/COL4A5/COL12A1/FXYD2	-4.10767861489157
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	13/2485	143/9376	0.343003475397842	ACTN1/SNRPB/SSB/RO60/SNRPD1/C1R/HLA-DPB1/HLA-DRB1/C1S/HLA-DPA1/HLA-DQB1/GRIN2B/HLA-DQA1	-4.75408982293093
NA	NA	hsa04082	Neuroactive ligand signaling	17/2485	199/9376	0.322319848740685	GNG12/PLCB4/ADCY4/GNB1/PLCB1/GNB4/GNG5/P2RX4/GNG11/GABBR1/GNB5/GNAS/GABRE/ADCY9/ADCY6/GRIA1/GRIN2B	-5.80241313800945
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	31/2485	298/9376	0.392497265472027	CCL21/CCL14/TGFBR2/IL7/TGFB2/BMP2/TNFRSF10B/TNFRSF10D/TNFRSF14/IL32/TNFRSF4/LTBR/GHR/TNFRSF11A/ACKR3/TNFRSF12A/RELL1/CSF1/IL15RA/IL15/ACVR1/LIF/CSF3/INHBB/ACVR1B/IL6R/CXCL1/TGFB3/CLCF1/TNFRSF10C/INHBA	-6.39983813253011
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	13/2485	370/9376	0.132566208059166	CALCRL/EDNRB/ADM/P2RX4/GABBR1/F2R/GHR/GABRE/F2RL3/GRIA1/GRIN2B/NMB/OXTR	-10.2230135660996
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	10/2485	449/9376	0.0840320318346605	PRKG1/PDE2A/CAMK2D/GNB1/ARRB1/PDE1A/ANO2/NCALD/CAMK2G/CALML4	-11.9442366473755