category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	62/860	203/9376	3.32977431550006	TNC/AKT3/ITGA5/PPP1R12B/COL4A5/LAMA3/THBS1/ACTN1/MAPK10/PARVA/ITGA7/PTK2/FLNB/PPP1R12A/VWF/EGFR/PIP5K1A/LAMA4/MYLK/CAV1/PIP5K1C/VCL/PIK3CB/PPP1R12C/BCL2/PRKCA/PDGFD/THBS3/COL4A6/FLNA/ITGA8/IGF1/MYL9/PAK3/TLN2/ITGB8/MAPK1/ITGB3/IGF1R/GSK3B/CAPN2/RAP1B/ACTN4/ITGB5/ARHGAP35/ITGA3/RAPGEF1/ZYX/ITGA6/EMP1/THBS2/PARVB/ITGAV/PDGFC/COL4A2/CAV2/PDGFA/PRKCB/DOCK1/PAK1/BRAF/MAP2K1	10.6640755388395
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	58/860	233/9376	2.71388362111987	MYH11/DMD/SGCD/ACTG2/TPM1/ITGA5/DES/PDLIM7/LMOD1/FLNC/PDLIM5/COL4A5/PDLIM3/SYNE1/DTNA/DIAPH3/MYH9/THBS1/CSRP1/ANK2/SYNPO2/ITGA7/HSPG2/SDC4/TMOD1/LDB3/VCL/TPM4/THBS3/COL4A6/FMN2/ITGA8/MYL9/TPM2/SDC3/SPTAN1/TLN2/ITGB8/DAAM1/SPTBN4/ITGB3/LMNA/DAG1/PDLIM4/ITGB5/PDLIM1/ITGA3/ZYX/LBR/ITGA6/THBS2/ITGAV/TMOD2/COL4A2/AMPD3/FMNL3/COL27A1/PKP2	8.41844669839466
NA	NA	hsa04518	Integrin signaling	43/860	154/9376	3.04415584415584	TNC/AKT3/ITGA5/COL4A5/LAMA3/THBS1/ACTN1/PARVA/ITGA7/PTK2/FLNB/LIMS1/VWF/EGFR/LAMA4/VCL/PIK3CB/PDGFD/THBS3/COL4A6/FLNA/ITGA8/IGF1/TLN2/ITGB8/FERMT2/ITGB3/IGF1R/GSK3B/ACTN4/ITGB5/ITGAE/ITGA3/ITGA6/THBS2/PARVB/ITGAV/PDGFC/COL4A2/MTOR/NPNT/PDGFA/LIMS2	8.12790917135417
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	51/860	204/9376	2.72558139534884	CD44/AKT3/ITGA5/PPP1R12B/THBS1/ANK2/TIMP3/HSPG2/RRAS2/PLCE1/PTK2/PLCG2/CAMK2G/PPP1R12A/EGFR/SDC4/CAV1/ESR1/TWIST2/PIK3CB/PPP1R12C/CAMK2D/MRAS/GAB1/PRKCA/PRKACB/ARHGEF12/FLNA/HOXD10/CTTN/IGF1/FZD3/WNT5A/MSN/MAPK1/ITGB3/IGF1R/TGFB2/CBL/ITGB5/PTPN11/ITGAV/CAV2/MTOR/PRKCB/SMAD2/PAK1/BRAF/ITPR1/MAP2K1/CAMK2A	7.91836556480536
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	40/860	154/9376	2.83177287828451	CACNB2/CACNA1C/OXTR/PPP1R12B/RCAN1/GUCY1A2/RYR3/CAMK2G/GNAO1/NFATC1/PPP1R12A/EGFR/ADCY5/GNAQ/MYLK/PLA2G4C/PPP1R12C/CAMK2D/PRKCA/PRKACB/CACNG4/MYL9/PPP3CA/ADCY2/CACNA2D1/MAPK1/CAMK1D/PPP3CB/PRKAB2/EEF2K/PRKAA2/PLCB4/CAMKK2/PRKCB/NPR1/NFATC4/ADCY9/ITPR1/MAP2K1/CAMK2A	7.28343859878003
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	36/860	134/9376	2.92898299201666	MYH11/CACNA1C/ACTG2/KCNMA1/PPP1R12B/EDNRA/PRKCE/MYH9/GUCY1A2/KCNMB1/PPP1R12A/CALD1/ADCY5/GNAQ/MYLK/PLA2G4C/PPP1R12C/PRKCA/PRKACB/ARHGEF12/MYL9/PRKG1/ADCY2/AVPR1A/RAMP1/MAPK1/GNA12/PLCB4/CALCRL/PRKCB/NPR1/PRKCH/BRAF/ADCY9/ITPR1/MAP2K1	7.14685305882346
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	51/860	232/9376	2.39663191659984	MYH11/AKT3/ITGA5/PPP1R12B/DIAPH3/MYH9/ACTN1/ENAH/ITGA7/RRAS2/ARHGEF7/PTK2/PPP1R12A/SSH2/EGFR/PIP5K1A/GSN/MYLK/PIP5K1C/VCL/PIK3CB/PPP1R12C/MRAS/PDGFD/ARHGEF12/ITGA8/MYL9/PAK3/SPATA13/ITGB8/MSN/MAPK1/ITGB3/ACTN4/ITGB5/ARHGAP35/ITGAE/ITGA3/ITGA6/ITGAV/PDGFC/GNA12/PDGFA/SSH1/DOCK1/F2R/GNG12/PAK1/BRAF/MAP2K1/ACTR3	6.84502255863902
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	31/860	105/9376	3.21878183831672	CACNB2/DMD/CACNA1C/SGCD/TPM1/ITGA5/DES/DTNA/ITGA7/ADCY5/PLN/TPM4/PRKACB/ITGA8/IGF1/CACNG4/TPM2/ADCY2/ITGB8/CACNA2D1/ITGB3/LMNA/DAG1/TGFB2/ITGB5/ITGA3/ITGA6/ITGAV/ATP2A2/SLC8A2/ADCY9	7.26545803703121
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	28/860	99/9376	3.08348602302091	CACNB2/DMD/CACNA1C/SGCD/TPM1/ITGA5/DES/DTNA/ITGA7/TPM4/ITGA8/IGF1/CACNG4/TPM2/ITGB8/CACNA2D1/ITGB3/LMNA/DAG1/TGFB2/ITGB5/PRKAB2/ITGA3/ITGA6/ITGAV/PRKAA2/ATP2A2/SLC8A2	6.62249208318709
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	36/860	149/9376	2.63411893241767	AKT3/PLPP1/RRAS2/PLCG2/EGFR/PIP5K1A/ADCY5/DGKI/PLA2G4C/PIP5K1C/PIK3CB/MRAS/GAB1/PRKCA/PDGFD/INSR/ADCY2/AVPR1A/DGKH/GRM7/SPHK1/MAPK1/PTPN11/PDGFC/GNA12/PLCB4/GAB2/MTOR/PDGFA/DGKE/F2R/PLPP2/ADCY9/MAP2K1/RAPGEF4/DNM3	6.38945142720299
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	57/860	300/9376	2.07144186046512	CACNB2/CACNA1C/AKT3/MAPK10/CACNA1H/RRAS2/DUSP5/NFATC1/EGFR/RELB/TGFBR1/IL1RAP/PLA2G4C/MRAS/MAP3K5/MAP3K4/PRKCA/PRKACB/PDGFD/FLNA/IGF1/RASGRP2/INSR/CACNG4/RPS6KA2/DUSP16/MAP3K13/PPP3CA/NR4A1/STK3/CACNA2D1/RASA2/MAPKAPK2/MAP2K3/MAPK1/IGF1R/RASA1/PPP3CB/MAP3K14/TGFB2/MAP3K10/RAP1B/NGF/PDGFC/NLK/HSPA6/GNA12/TAOK3/PDGFA/RASGRF2/PRKCB/TAOK1/NF1/GNG12/PAK1/BRAF/MAP2K1	5.99375561180588
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	38/860	166/9376	2.49571308489773	CACNA1C/ATP2B4/AKT3/CREB5/KCNMA1/EDNRA/PRKCE/GUCY1A2/KCNMB1/NFATC1/PPP1R12A/ADCY5/GNAQ/MYLK/PLN/TRPC6/INSR/MYL9/PPP3CA/PRKG1/ADCY2/CREB3L2/MAPK1/PPP3CB/MEF2A/ADRA2C/GNA12/PLCB4/PDE5A/ATP2A2/NPR1/SLC8A2/NFATC4/MEF2D/MEF2B/ADCY9/ITPR1/MAP2K1	6.17859259179674
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	31/860	122/9376	2.77026305756767	AKT3/FOXO1/CREB5/TBC1D1/PPP2R3A/ACACB/PIK3CB/RPTOR/CPT1A/CAB39L/IGF1/PPARG/INSR/CAB39/CREB3L2/PFKFB3/ACACA/IGF1R/GYS1/SREBF1/PPP2R2C/STRADA/PRKAB2/EEF2K/PRKAA2/MTOR/CAMKK2/LEPR/PPP2R5C/PPP2R5B/PPP2CB	6.25417474715327
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	25/860	86/9376	3.16928069226609	CACNB2/DMD/CACNA1C/SGCD/ITGA5/DES/DTNA/TCF7L2/ITGA7/ITGA8/TCF7L1/CACNG4/ITGB8/CACNA2D1/ITGB3/CTNNA1/LMNA/DAG1/ITGB5/ITGA3/ITGA6/ITGAV/ATP2A2/SLC8A2/PKP2	6.42205701460735
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	39/860	184/9376	2.3108190091001	TRPC4/SLIT3/SEMA3C/ENAH/PTK2/PLCG2/CAMK2G/SSH2/PIK3CB/CAMK2D/ABLIM1/PRKCA/ARHGEF12/PARD3/TRPC6/BMPR1B/MYL9/PAK3/PPP3CA/FZD3/NEO1/WNT5A/MAPK1/GSK3B/RASA1/PPP3CB/ABL1/BOC/PTPN11/NTN4/SSH1/PLXNA4/NFATC4/RGMA/BMPR2/SEMA4A/PAK1/CAMK2A/NTN1	5.70641919487584
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	13/860	29/9376	4.88724939855654	FAT4/FRMD6/YAP1/STK3/TEAD1/LIMD1/RASSF2/TEAD2/WWTR1/MOB1B/RASSF1/PAK1/CSNK1E	6.66227139342677
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	46/860	238/9376	2.10717217119406	AKT3/MAPK10/RRAS2/PLCE1/PLCG2/EGFR/RASAL2/PLA2G4C/ABL2/PIK3CB/MRAS/GAB1/PRKCA/PRKACB/PDGFD/RALGAPA1/IGF1/RASGRP2/INSR/GNB1/PAK3/RASA2/SYNGAP1/MAPK1/IGF1R/GNB5/RASA1/RAP1B/EXOC2/ABL1/PTPN11/NGF/PDGFC/GAB2/PDGFA/RASGRF2/PRKCB/RASA4/RAPGEF5/KSR1/NF1/GNG12/RASSF1/PAK1/MAP2K1/GNG4	5.49787802401401
NA	NA	hsa04517	IgSF CAM signaling	54/860	299/9376	1.96898187757642	MYH11/SORBS1/AKT3/FOXO1/ITGA5/TRIO/NCAM1/SLIT3/MYH9/ACTN1/MAPK10/ANK2/NLGN1/MAGI2/SCN8A/PTK2/PLCG2/MYLK/IL1RAP/VCL/MAGI1/PIK3CB/TUBB6/PRKCA/PVR/PARD3/PTPRS/TJP2/TRPC6/MYL9/PAK3/CD2AP/TUBA1A/SPTAN1/SPTBN4/MSN/MAPK1/ITGB3/GSK3B/RASA1/RAP1B/ACTN4/ABL1/PTPN11/CNTNAP1/GRIP1/PPFIA2/ERC1/PRKCB/PLXNA4/PAK1/MAP2K1/ACTR3/NTN1	5.41124401644108
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	48/860	254/9376	2.06028199963377	CACNA1C/PTGER3/ATP2B4/OXTR/GNA14/EDNRA/STIM1/ITPKB/RYR3/CACNA1H/PLCE1/PLCG2/CAMK2G/NFATC1/EGFR/GNAQ/MYLK/PLN/CAMK2D/PRKCA/PRKACB/PDGFD/MCU/PPP3CA/ADCY2/AVPR1A/SPHK1/CAMK1D/PPP3CB/STIM2/ASPH/PDE1A/NGF/GNAL/ITPKC/PDGFC/HTR2A/PLCB4/PDGFA/PRKCB/CASQ2/ATP2A2/SLC8A2/NFATC4/F2R/ADCY9/ITPR1/CAMK2A	5.44390139509983
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	24/860	89/9376	2.93995296576953	TNC/CD44/ITGA5/COL4A5/LAMA3/THBS1/ITGA7/HSPG2/VWF/SDC4/LAMA4/THBS3/COL4A6/ITGA8/ITGB8/ITGB3/DAG1/ITGB5/ITGA3/ITGA6/THBS2/ITGAV/COL4A2/NPNT	5.84339868601835
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	25/860	97/9376	2.80987772716375	CACNA1C/GUCY1A2/RYR3/CACNA1H/CAMK2G/GNAO1/ADCY5/GNAQ/CAMK2D/PRKCA/PRKACB/GNB1/PRKG1/ADCY2/PER2/MAPK1/GNB5/PLCB4/PRKCB/PER3/GNG12/ADCY9/ITPR1/GNG4/CAMK2A	5.69379140810714
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	34/860	157/9376	2.36101318323211	SERPINE1/BMPR1A/TCF7L2/FRMD6/TGFBR1/PARD3/YAP1/DLG2/TCF7L1/BMPR1B/FZD3/STK3/BTRC/WNT5A/GSK3B/CTNNA1/TEAD1/TGFB2/LIMD1/PPP2R2C/DLG5/SMAD1/YWHAG/TEAD2/BMP8A/SMAD2/BMPR2/WWTR1/DLG1/MOB1B/RASSF1/NKD1/CSNK1E/PPP2CB	5.46496378212126
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	23/860	86/9376	2.9157382368848	AKT3/MAPK10/PTK2/PLCG2/CAMK2G/EGFR/ABL2/PIK3CB/CAMK2D/GAB1/PRKCA/PAK3/MAPK1/GSK3B/CBL/ABL1/CBLB/MTOR/PRKCB/PAK1/BRAF/MAP2K1/CAMK2A	5.67145608505165
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	30/860	133/9376	2.45917118377339	CACNA1C/AKT3/CREB5/MAOB/MAPK10/PPP2R3A/CAMK2G/GNAO1/ADCY5/GNAQ/CAMK2D/PRKCA/PRKACB/GNB1/PPP3CA/CREB3L2/GSK3B/GNB5/PPP3CB/PPP2R2C/GNAL/PLCB4/PRKCB/GNG12/ITPR1/PPP2R5C/PPP2R5B/GNG4/CAMK2A/PPP2CB	5.38570579943402
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	31/860	140/9376	2.41408637873754	AKT3/SERPINE1/PRKCE/HDAC4/RYR3/RRAS2/ADCY5/GNAQ/TGFBR1/MYLK/MRAS/PRKACB/GNB1/ADCY2/SPHK1/MAPK1/GNB5/MEF2A/PRKAB2/PRKAA2/PLCB4/MTOR/SLC8A2/SMAD2/MEF2D/MEF2B/GNG12/ADCY9/ITPR1/MAP2K1/GNG4	5.35691841367032
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	41/860	212/9376	2.10846862659061	AKT3/THBS1/ENAH/MAGI2/PLCE1/CNR1/GNAO1/EGFR/ADCY5/GNAQ/MAGI1/PIK3CB/MRAS/PRKCA/PDGFD/PARD3/IGF1/RASGRP2/CTNND1/INSR/ADCY2/TLN2/MAP2K3/MAPK1/ITGB3/IGF1R/PRKD1/RAP1B/NGF/RAPGEF1/PDGFC/SIPA1L3/PLCB4/PDGFA/PRKCB/RAPGEF5/F2R/BRAF/ADCY9/MAP2K1/RAPGEF4	5.18759225595884
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	36/860	178/9376	2.20496472432715	ROR2/MAPK10/TCF7L2/ROR1/CAMK2G/NFATC1/FOSL1/CAMK2D/TBL1X/PRKCA/PRKACB/PRICKLE2/TCF7L1/PPP3CA/LGR4/FZD3/DAAM1/BTRC/TLE2/WNT5A/GSK3B/PPP3CB/ZNRF3/NLK/PLCB4/PRKCB/NFATC4/INVS/TLE4/LRP6/NKD1/GPC4/CSNK1E/CHD8/CAMK2A/MMP7	5.15768327123332
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	24/860	98/9376	2.66995728523968	CACNA1C/ATP2B4/CREB5/PRKCE/CACNA1H/CAMK2G/LDLR/ADCY5/GNAQ/CAMK2D/PRKCA/PRKACB/ADCY2/CREB3L2/NR4A1/CAMK1D/DAGLB/PRKD1/PLCB4/PRKCB/NPR1/ADCY9/ITPR1/CAMK2A	5.28090377256381
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	59/860	362/9376	1.77689836823847	TNC/AKT3/CREB5/ITGA5/COL4A5/LAMA3/THBS1/PPP2R3A/ITGA7/MAGI2/PTK2/VWF/EGFR/LAMA4/MAGI1/PIK3CB/RPTOR/BCL2/PRKCA/PDGFD/THBS3/COL4A6/ITGA8/IGF1/INSR/GNB1/CREB3L2/NR4A1/ITGB8/MAPK1/ITGB3/IGF1R/GSK3B/GNB5/GYS1/IL6R/ITGB5/PPP2R2C/NGF/ITGA3/ITGA6/THBS2/ITGAV/PDGFC/COL4A2/PRKAA2/MTOR/YWHAG/PDGFA/PHLPP2/F2R/SGK3/GNG12/CSF3/MAP2K1/PPP2R5C/PPP2R5B/GNG4/PPP2CB	4.79045489208698
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	32/860	154/9376	2.26541830262761	CACNB2/CACNA1C/ATP2B4/AKT3/CREB5/TPM1/PPP2R3A/CAMK2G/ADCY5/GNAQ/PLN/CAMK2D/TPM4/BCL2/PRKCA/PRKACB/CACNG4/TPM2/ADCY2/CREB3L2/CACNA2D1/MAPK1/PPP2R2C/PLCB4/ATP2A2/SLC8A2/ADCY9/PPP2R5C/PPP2R5B/RAPGEF4/CAMK2A/PPP2CB	5.03151707191568
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	26/860	115/9376	2.46487360970677	CACNA1C/AKT3/CREB5/CAMK2G/GNAO1/ADCY5/GNAQ/PIK3CB/CAMK2D/BCL2/PRKCA/PRKACB/GNB1/ADCY2/CREB3L2/MAPK1/GNB5/KCNQ4/PLCB4/PRKCB/GNG12/ADCY9/ITPR1/MAP2K1/GNG4/CAMK2A	5.02269920853292
Organismal Systems	Nervous system	hsa04730	Long-term depression	17/860	60/9376	3.08899224806202	GUCY1A2/GNAO1/GNAQ/PLA2G4C/PRKCA/IGF1/PRKG1/MAPK1/IGF1R/GNAZ/GNA12/PLCB4/PRKCB/BRAF/ITPR1/MAP2K1/PPP2CB	5.15839685588395
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	23/860	99/9376	2.53286351891003	PRKCE/MAPK10/PLCG2/CAMK2G/ADCY5/GNAQ/IL1RAP/PLA2G4C/PIK3CB/CAMK2D/PRKCA/PRKACB/IGF1/ADCY2/MAP2K3/NGF/HTR2A/PLCB4/PRKCB/PRKCH/ADCY9/ITPR1/CAMK2A	4.8723036326729
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	20/860	80/9376	2.72558139534884	AKT3/PLCG2/EGFR/PIK3CB/GAB1/BCL2/PRKCA/PDGFD/IGF1/MAPK1/IGF1R/GSK3B/IL6R/PDGFC/MTOR/PDGFA/PRKCB/NF1/BRAF/MAP2K1	4.92548978941789
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	12/860	34/9376	3.84787961696306	RORA/BTRC/RORB/PER2/NPAS2/BHLHE40/PRKAB2/PRKAA2/PER3/CSNK1E/NR1D1/NR1D2	5.28637772971548
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	24/860	109/9376	2.40051205461916	AKT3/FOXO1/CREB5/PRKCE/MAPK10/PYGB/ACACB/PIK3CB/CPT1A/INSR/RPS6KA2/CREB3L2/PPARGC1B/GSK3B/GYS1/SREBF1/MLXIP/PTPN11/PRKAB2/PRKAA2/MTOR/PTPN1/PRKCB/SLC27A4	4.67355713279453
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	17/860	65/9376	2.85137745974955	CACNA1C/PBX1/CREB5/PDE8B/CACNA1H/LDLR/ADCY5/GNAQ/PRKACB/PDE8A/ADCY2/CREB3L2/NR4A1/NCEH1/PLCB4/ADCY9/ITPR1	4.75960075112244
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	22/860	98/9376	2.44746084480304	INPP4B/ITPKB/PLCE1/PLCG2/PIP5K1A/DGKI/PIP5K1C/PIK3CB/ITPK1/INPP4A/PRKCA/INPP5B/PI4KA/DGKH/INPP5F/SYNJ2/ITPKC/PLCB4/PRKCB/DGKE/IPPK/ITPR1	4.57730356549909
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	30/860	155/9376	2.11012753188297	CACNA1C/PBX1/CREB5/PDE8B/TCF7L2/CACNA1H/CAMK2G/LDLR/EGFR/ADCY5/GNAQ/CAMK2D/PRKACB/PDE8A/TCF7L1/ADCY2/CREB3L2/NR4A1/FZD3/WNT5A/MAPK1/GSK3B/RAP1B/NCEH1/PLCB4/BRAF/ADCY9/ITPR1/MAP2K1/CAMK2A	4.42860299159678
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	21/860	93/9376	2.46181545386347	SORBS1/ACTN1/TCF7L2/PTPRM/EGFR/TGFBR1/VCL/PARD3/ARHGAP29/PTPRJ/CTNND1/INSR/TCF7L1/MYL9/MAPK1/IGF1R/CTNNA1/RAP1B/ACTN4/NLK/PTPN1	4.50201445703042
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	17/860	67/9376	2.7662617146824	CACNA1C/CAMK2G/GNAQ/CAMK2D/PRKCA/PRKACB/RPS6KA2/PPP3CA/MAPK1/PPP3CB/RAP1B/PLCB4/PRKCB/BRAF/ITPR1/MAP2K1/CAMK2A	4.61060565859957
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	27/860	138/9376	2.13306370070779	PGR/CAMK2G/CPEB2/ADCY5/CAMK2D/PRKACB/IGF1/CPEB3/RPS6KA2/PPP3CA/ADCY2/BTRC/AR/MAPK1/IGF1R/PPP3CB/ANAPC7/YWHAG/CPEB4/MAD1L1/ADCY9/ITPR1/MAP2K1/PPP2R5C/PPP2R5B/CAMK2A/PPP2CB	4.26110198020385
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	27/860	138/9376	2.13306370070779	SORBS1/AKT3/FOXO1/MAPK10/PYGB/PRKAR1B/ACACB/PIK3CB/RPTOR/PRKACB/INSR/MAPK1/ACACA/GSK3B/GYS1/SREBF1/CBL/PRKAR2A/PRKAB2/RAPGEF1/CBLB/PRKAA2/PRKAR2B/MTOR/PTPN1/BRAF/MAP2K1	4.26110198020385
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	20/860	89/9376	2.44996080480794	GUCY1A2/EGFR/ADCY5/GNAQ/TUBB6/PRKCA/PRKACB/PDGFD/PRKG1/TUBA1A/ADCY2/MAPK1/PDGFC/HTR2A/PLCB4/PDGFA/PRKCB/ADCY9/ITPR1/MAP2K1	4.36747653736643
Human Diseases	Cancer: specific types	hsa05214	Glioma	18/860	76/9376	2.58212974296206	AKT3/PLCG2/CAMK2G/EGFR/PIK3CB/CAMK2D/PRKCA/IGF1/MAPK1/IGF1R/CAMK1D/DDB2/MTOR/PDGFA/PRKCB/BRAF/MAP2K1/CAMK2A	4.40072726857313
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	25/860	125/9376	2.18046511627907	AKT3/PRKCE/MAPK10/SGMS2/ABCC1/PPP2R3A/GNAQ/PIK3CB/MAP3K5/BCL2/PRKCA/CERS4/SPHK1/MAPK1/PPP2R2C/CERS6/GNA12/PLCB4/GAB2/PRKCB/MAP2K1/PPP2R5C/PPP2R5B/PPP2CB/NSMAF	4.22212280721988
Organismal Systems	Immune system	hsa04611	Platelet activation	25/860	126/9376	2.16315983757844	AKT3/STIM1/GUCY1A2/PLCG2/PPP1R12A/VWF/ADCY5/GNAQ/MYLK/PLA2G4C/PIK3CB/PRKACB/ARHGEF12/RASGRP2/PRKG1/ADCY2/TLN2/MAPK1/ITGB3/RAP1B/ARHGAP35/PLCB4/F2R/ADCY9/ITPR1	4.17706123282963
Human Diseases	Substance dependence	hsa05032	Morphine addiction	20/860	91/9376	2.39611551239458	PDE10A/PDE8B/PDE4D/PDE7B/GNAO1/ADCY5/PRKCA/PRKACB/PDE8A/GNB1/ADCY2/GNB5/GRK4/PDE1A/GABBR1/PDE7A/PRKCB/GNG12/ADCY9/GNG4	4.25273314672183
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	21/860	99/9376	2.31261451726568	AKT3/PLPP1/MAPK10/EGFR/PIP5K1A/DGKI/PLA2G4C/PIP5K1C/PIK3CB/PRKCA/PDGFD/DGKH/MAPK1/PDGFC/MTOR/PCYT1A/PDGFA/PRKCB/DGKE/PLPP2/MAP2K1	4.17222825246722
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	19/860	86/9376	2.40865332612223	CACNA1C/CREB5/KCNMA1/KCNN2/CAMK2G/KCNMB1/ADCY5/GNAQ/CAMK2D/PRKCA/PRKACB/ADCY2/CREB3L2/PLCB4/PRKCB/TRPM4/ADCY9/RAPGEF4/CAMK2A	4.17025422594024
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	22/860	107/9376	2.24159965224951	AKT3/FOXO1/CREB5/CAMK2G/PYGB/GNAQ/ACACB/CAMK2D/PRKACB/CPT1A/PPP3CA/ADCY2/CREB3L2/ACACA/PPP3CB/GYS1/SIK2/PRKAB2/PRKAA2/PLCB4/ITPR1/CAMK2A	4.10463049598108
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	20/860	93/9376	2.34458614653663	CACNA1C/MAPK10/CAMK2G/EGFR/ADCY5/GNAQ/PLA2G4C/CAMK2D/MAP3K4/PRKCA/PRKACB/ADCY2/MAP2K3/MAPK1/PLCB4/PRKCB/ADCY9/ITPR1/MAP2K1/CAMK2A	4.14097843502217
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	24/860	122/9376	2.144719786504	AKT3/FOXO1/RCAN1/PLCE1/PLCG2/ESR1/PLN/PIK3CB/PRKCA/PRKACB/MAPK1/ITGB3/GSK3B/MED27/MED12L/ITGAV/PLCB4/MTOR/MED13/PRKCB/ATP2A2/KAT2A/MAP2K1/NCOA3	4.04418854628126
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	23/860	115/9376	2.18046511627907	CREB5/PDE4D/AKAP13/EGFR/ADCY5/GNAQ/BCL2/PRKCA/PRKACB/ADCY2/CREB3L2/MAPK1/MEF2A/GNA12/PLCB4/PRKCB/STK39/MEF2D/LRP6/BRAF/ADCY9/ITPR1/MAP2K1	4.04753090365417
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	25/860	130/9376	2.09660107334526	AKT3/CREB5/COL4A5/MAPK10/GNAO1/EGFR/ADCY5/TGFBR1/PIK3CB/PRKCA/PRKACB/COL4A6/GNB1/ADCY2/CREB3L2/MAPK1/GNB5/COL4A2/PLCB4/SMAD2/RXFP1/GNG12/ADCY9/MAP2K1/GNG4	4.00092523359595
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	21/860	101/9376	2.26682017038913	MITF/TCF7L2/CAMK2G/GNAO1/ADCY5/GNAQ/CAMK2D/PRKCA/PRKACB/TCF7L1/ADCY2/CREB3L2/FZD3/WNT5A/MAPK1/GSK3B/PLCB4/PRKCB/ADCY9/MAP2K1/CAMK2A	4.06757654895166
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/860	101/9376	2.26682017038913	AKT3/FOXO1/SERPINE1/COL4A5/PRKCE/MAPK10/PLCE1/PLCG2/NFATC1/TGFBR1/PIK3CB/BCL2/PRKCA/COL4A6/MAPK1/TGFB2/NOX4/COL4A2/PLCB4/PRKCB/SMAD2	4.06757654895166
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	23/860	116/9376	2.1616680032077	CACNA1C/HOMER1/GNAO1/ADCY5/GNAQ/PLA2G4C/PRKCA/PRKACB/GLS/GNB1/PPP3CA/ADCY2/GRM7/MAPK1/GNB5/PPP3CB/PLCB4/PRKCB/SLC1A2/GNG12/ADCY9/ITPR1/GNG4	4.0005763764453
Cellular Processes	Cell motility	hsa04814	Motor proteins	33/860	194/9376	1.85451929992807	MYH11/ACTG2/TPM1/MYO1D/MYH9/KIF13B/MYO6/MYO1E/KIF13A/MYO9B/KLC1/KIF21A/DYNC1I1/TUBB6/TPM4/KIF1B/DNAH7/HOOK3/DYNC2LI1/MYL9/TPM2/TUBA1A/KIF16B/STARD9/DYNC1H1/MYO5A/MYO18A/KIFC2/KIF2A/MYO16/MYO9A/KIFAP3/DNAL1	3.82182796757763
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	15/860	62/9376	2.63765941485371	AKT3/FOXO1/ADCY5/PIK3CB/RPTOR/PRKACB/IGF1/INSR/ADCY2/IGF1R/PRKAB2/HSPA6/PRKAA2/MTOR/ADCY9	4.11119760507514
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	19/860	90/9376	2.30160206718346	AKT3/FOXO1/CREB5/ADCY5/PIK3CB/RPTOR/PRKACB/IGF1/PPARG/INSR/ADCY2/CREB3L2/IGF1R/EHMT1/PRKAB2/PRKAA2/MTOR/CAMKK2/ADCY9	3.94277670683563
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	28/860	157/9376	1.94436379795586	PBX1/SLC16A1/THBS1/DUSP5/XKR6/PTK2/CAMK2G/NFATC1/CAMK2D/CPT1A/ANO6/PPARG/ADAM17/DUSP16/MAPKAPK2/SPHK1/MAPK1/ITGB3/ITGB5/PTPN11/ITGAV/ATP2A2/NFATC4/DOCK1/ANO4/MAP2K1/CAMK2A/MFGE8	3.79196470435296
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	21/860	105/9376	2.18046511627907	AKT3/MAPK10/RRAS2/PLCG2/NFATC1/RELB/PIK3CB/MRAS/ARHGEF12/PPP3CA/MAPKAPK2/PLK3/MAPK1/PPP3CB/MAP3K14/PTPN11/CBLB/NFATC4/KSR1/PAK1/ITPR1	3.86546329990307
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	20/860	98/9376	2.2249644043664	AKT3/PLPP1/PRKCE/PLCG2/PIP5K1A/GSN/PLA2G4C/PIP5K1C/PIK3CB/PRKCA/SPHK1/MAPK1/GAB2/ASAP3/PRKCB/DOCK1/PLPP2/PAK1/MAP2K1/ACTR3	3.87370335843437
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	21/860	106/9376	2.1598946906538	AKT3/FOXO1/CREB5/TCF7L2/EGFR/PIK3CB/ZEB1/BCL2/PDGFD/IGF1/TCF7L1/CREB3L2/AR/MAPK1/IGF1R/GSK3B/PDGFC/MTOR/PDGFA/BRAF/MAP2K1	3.81635409659759
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	17/860	78/9376	2.37614788312463	ITGA5/PTK2/CAV1/VCL/SEPTIN9/PIK3CB/GAB1/CTTN/CD2AP/CTNNA1/CBL/ARHGEF26/CAV2/ARHGAP10/DOCK1/ACTR3/DNM3	3.87823993685012
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	23/860	122/9376	2.05535646206634	CACNA1C/AKT3/CREB5/MAPK10/PTK2/PLCG2/ADCY5/GNAQ/PIK3CB/PRKCA/PRKACB/IGF1/ADCY2/CREB3L2/MAP2K3/MAPK1/GSK3B/PLCB4/MTOR/PRKCB/ADCY9/ITPR1/MAP2K1	3.72847623187097
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	22/860	115/9376	2.0856622851365	CACNA1C/MAOB/KCNN2/GNAO1/ADCY5/GNAQ/PLA2G4C/PRKCA/PRKACB/GNB1/MAPK1/GNB5/HTR2A/PLCB4/PRKCB/CYP4X1/KCND2/GNG12/BRAF/ITPR1/MAP2K1/GNG4	3.72247480202792
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	36/860	227/9376	1.72900317590411	PTGER3/AKT3/CREB5/AKAP13/PTK2/GNAO1/NFATC1/EGFR/ADCY5/GNAQ/PIK3CB/PRKCA/PRKACB/ARHGEF12/GNB1/PPP3CA/ADCY2/CREB3L2/MAPK1/ITGB3/GSK3B/GNB5/PPP3CB/IL6R/TRAF5/ITGAV/GNA12/PLCB4/MTOR/PRKCB/NFATC4/GNG12/ADCY9/ITPR1/MAP2K1/GNG4	3.53323539608205
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	48/860	333/9376	1.57150639011104	TNC/AKT3/FOXO1/CREB5/ITGA5/COL4A5/LAMA3/THBS1/TCF7L2/PPP2R3A/ITGA7/PTK2/VWF/EGFR/LAMA4/MAGI1/PIK3CB/PRKACB/THBS3/COL4A6/PARD3/HES4/DLG2/ITGA8/TCF7L1/ATP6V0A1/CREB3L2/FZD3/ITGB8/WNT5A/MAPK1/ITGB3/GSK3B/TRAF3/ITGB5/PPP2R2C/ITGA3/ITGA6/THBS2/ITGAV/COL4A2/MTOR/DLG1/MAP2K1/PPP2R5C/PPP2R5B/PPP2CB/ATP6V1H	3.37445762984806
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	10/860	36/9376	3.02842377260982	GALNT17/GALNT18/GCNT4/ST6GALNAC3/GALNT13/GALNT16/B4GALT5/GALNT7/GALNT15/ST3GAL2	3.87483792221593
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/860	120/9376	1.99875968992248	AKT3/MAPK10/PLCG2/CAMK2G/PIK3CB/CAMK2D/GAB1/MAP3K5/BCL2/RPS6KA2/MAPKAPK2/MAPK1/GSK3B/RAP1B/ABL1/PTPN11/NGF/RAPGEF1/SH2B1/BRAF/MAP2K1/CAMK2A	3.49910514900172
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	35/860	226/9376	1.68841325375592	CACNA1C/PTGER3/ATP2B4/AKT3/OXTR/CREB5/PDE10A/EDNRA/PDE4D/MAPK10/RRAS2/PLCE1/CAMK2G/NFATC1/PPP1R12A/ADCY5/PLN/PIK3CB/CAMK2D/PRKACB/MYL9/ADCY2/CREB3L2/MAPK1/RAP1B/GABBR1/ATP2A2/NPR1/F2R/PAK1/BRAF/ADCY9/MAP2K1/RAPGEF4/CAMK2A	3.32897039567185
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	16/860	78/9376	2.23637447823494	INPP4B/ITPKB/PLCE1/PLCG2/PIP5K1A/PIP5K1C/PIK3CB/ITPK1/INPP4A/INPP5B/PI4KA/INPP5F/SYNJ2/ITPKC/PLCB4/IPPK	3.48433256134198
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	14/860	65/9376	2.34819320214669	CACNA1C/AKT3/TRPC4/KCNN2/CACNA1H/GNAQ/PIK3CB/PRKCA/MAPK1/GABBR1/PLCB4/PRKCB/ITPR1/MAP2K1	3.46599303335129
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	20/860	110/9376	1.98224101479915	AKT3/SERPINE1/PLCG2/CAMK2G/EGFR/PIK3CB/CAMK2D/BCL2/PRKCA/IGF1/INSR/PFKFB3/MAPK1/IGF1R/TF/IL6R/MTOR/PRKCB/MAP2K1/CAMK2A	3.29295121586531
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	24/860	142/9376	1.84264657713724	UBE2G1/UBE2E2/KLHL13/UBE2H/PRKN/HERC4/HERC1/UBE2G2/UBE2R2/UBR5/BTRC/MID1/ITCH/CBL/UBE2K/ANAPC7/SAE1/COP1/CBLB/FANCL/DDB2/BIRC6/UBE4B/TRIM37	3.21522770569211
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	13/860	60/9376	2.36217054263566	AKT3/PTK2/PLCG2/PLA2G4C/PIK3CB/PRKCA/PPP3CA/MAPKAPK2/SPHK1/MAPK1/PPP3CB/PRKCB/MAP2K1	3.36363921447205
NA	NA	hsa04081	Hormone signaling	33/860	219/9376	1.64281618349793	OXTR/GNA14/BMPR1A/GNAO1/ADCY5/GNAQ/ESR1/PIK3CB/PRKACB/IGF1/INSR/ACVR1/BMPR1B/GNB1/PRKG1/ADCY2/AVPR1A/HEPH/RAMP1/ITGB3/IGF1R/GNB5/SMAD1/ITGAV/ADRA2C/GNA12/PLCB4/LEPR/NPR1/GNG12/ADCY9/RAPGEF4/GNG4	3.05878738044246
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	27/860	169/9376	1.74179166093298	AKT3/MAPK10/RRAS2/VMP1/PIK3CB/MRAS/RPTOR/BCL2/PRKACB/DEPTOR/ATG10/MAPK1/IGF1R/AMBRA1/ATG7/CFLAR/PRKAA2/MTOR/CAMKK2/DAPK3/BIRC6/WDR41/ZFYVE1/RUBCN/ITPR1/MAP2K1/PPP2CB	3.09231170932885
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	27/860	170/9376	1.73154582763338	AKT3/TXNRD1/TCF7L2/PLCG2/EGFR/TGFBR1/PIK3CB/GAB1/PRKCA/MGST1/TCF7L1/FZD3/WNT5A/MAPK1/IGF1R/GSK3B/TGFB2/DDB2/MTOR/GSTM2/PRKCB/SMAD2/ARID1B/SMARCA4/LRP6/BRAF/MAP2K1	3.05877513068108
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/860	99/9376	1.98224101479915	AKT3/MAPK10/PTK2/EGFR/ADCY5/ESR1/PIK3CB/BCL2/PRKACB/IGF1/ADCY2/MAPK1/IGF1R/MTOR/BRAF/ADCY9/MAP2K1/NCOA3	3.12211518215871
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	23/860	139/9376	1.80398193073448	AKT3/CREB5/GREB1/PGR/GNAO1/EGFR/ADCY5/GNAQ/ESR1/PIK3CB/BCL2/PRKACB/ADCY2/CREB3L2/MAPK1/GABBR1/HSPA6/PLCB4/ADCY9/ITPR1/FKBP5/MAP2K1/NCOA3	3.03462655568798
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	12/860	56/9376	2.33621262458472	GPR161/BCL2/PRKACB/BTRC/SPOP/GSK3B/BOC/MEGF8/PTCH2/CSNK1G1/HHAT/CSNK1E	3.18697506411283
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/860	93/9376	1.99289822455614	AKT3/COL4A5/LAMA3/PTK2/LAMA4/PIK3CB/BCL2/COL4A6/FHIT/TRAF3/TRAF5/ITGA3/ITGA6/ITGAV/DDB2/COL4A2/TRAF1	3.0578703689974
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	25/860	157/9376	1.73603910531773	AKT3/FOXO1/SERPINE1/RRAS2/NFATC1/TGFBR1/NBN/PIK3CB/MRAS/MCU/RAD9A/PPP3CA/BTRC/MAPKAPK2/MAP2K3/MAPK1/PPP3CB/CAPN2/TGFB2/MTOR/SMAD2/NFATC4/ITPR1/MAP2K1/TRAF3IP2	2.95546516546881
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	22/860	133/9376	1.80339220143382	AKT3/FOXO1/HOMER1/MAPK10/EGFR/TGFBR1/PIK3CB/IGF1/BCL6/INSR/PLK3/MAPK1/IGF1R/TGFB2/PRKAB2/NLK/PRKAA2/FBXO32/SGK3/BRAF/MAP2K1/CSNK1E	2.96526828832589
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	25/860	158/9376	1.72505151604357	AKT3/CLIP1/PIK3CB/RPTOR/PRKCA/CAB39L/IGF1/INSR/RPS6KA2/DEPTOR/CAB39/FZD3/WNT5A/MAPK1/IGF1R/GSK3B/STRADA/MAPKAP1/PRKAA2/MTOR/PRKCB/LRP6/BRAF/MAP2K1/ATP6V1H	2.9207614909964
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	19/860	110/9376	1.8831289640592	AKT3/PGR/MAPK10/CPEB2/ADCY5/PIK3CB/PRKACB/IGF1/CPEB3/RPS6KA2/ADCY2/MAPK1/IGF1R/ANAPC7/CPEB4/MAD1L1/BRAF/ADCY9/MAP2K1	2.96067925503929
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/860	87/9376	2.0050253942796	AKT3/MAPK10/TCF7L2/EGFR/TGFBR1/PIK3CB/BCL2/TCF7L1/MAPK1/GSK3B/TGFB2/DDB2/MTOR/SMAD2/BRAF/MAP2K1	2.99274158036552
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/860	103/9376	1.90526078121472	GNA14/COL4A5/LAMA3/ACTN1/PTK2/GNAQ/LAMA4/VCL/PIK3CB/PRKCA/PRKACB/COL4A6/TGFB2/ACTN4/GNAL/COL4A2/PLCB4/PRKCB	2.93561586199825
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	20/860	119/9376	1.83232362712527	AKT3/CREB5/IL15/MAPK10/DAB2IP/PIK3CB/MAP3K5/ADAM17/CREB3L2/MAP2K3/MAPK1/MAP3K14/TRAF3/ITCH/TRAF5/CFLAR/DNM1L/TNFAIP3/TRAF1/MAP2K1	2.90367235207489
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	21/860	128/9376	1.78866279069767	PDE10A/PDE8B/PDE4D/PDE7B/GUCY1A2/ADCY5/FHIT/NT5E/PDE8A/ADK/ADCY2/NT5C2/PDE1A/ENTPD1/PDE7A/AK4/AMPD3/PDE5A/NPR1/ADCY9/ENTPD4	2.85489054917403
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	26/860	170/9376	1.66741450068399	MYH11/PRKCE/MYH9/ACTN1/MAPK10/MAGI1/MAP3K5/PRKACB/PARD3/CTTN/DLG2/TJP2/MYL9/MICALL2/TUBA1A/MSN/ARHGEF18/ACTN4/PPP2R2C/PRKAB2/HSPA4/ARHGAP17/PRKAA2/DLG1/ACTR3/PPP2CB	2.79062609536369
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	16/860	89/9376	1.95996864384635	PLCL1/CACNA1C/GNAO1/ADCY5/GPHN/PRKCA/PRKACB/GLS/GNB1/ADCY2/GNB5/GABBR1/PRKCB/GNG12/ADCY9/GNG4	2.8915543887145
NA	NA	hsa04519	Cadherin signaling	52/860	404/9376	1.40326962928851	CDH13/PCDH7/DES/MYO1D/ACTN1/MAPK10/TCF7L2/ENAH/FAT1/FAT4/RRAS2/MYO1E/PTK2/EGFR/LHFPL2/VCL/FAT3/MRAS/PRICKLE2/YAP1/LIMA1/CTNND1/TCF7L1/LHFPL6/FZD3/STK3/RERE/DAAM1/MAP2K3/WNT5A/MAPK1/IGF1R/GSK3B/CTNNA1/TEAD1/ACTN4/LIMD1/ARHGAP35/CDH26/ERBIN/YWHAG/TAOK3/TEAD2/TAOK1/LHFPL3/WWTR1/LRP6/MOB1B/MAP2K1/ACTR3/PKP2/CDH6	2.63304695269616
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	20/860	122/9376	1.78726648875334	AKT3/MAPK10/PPP2R3A/NFATC1/PIK3CB/PAK3/PPP3CA/MAPK1/GSK3B/PPP3CB/MAP3K14/PPP2R2C/PTPN11/CBLB/DLG1/PAK1/MAP2K1/PPP2R5C/PPP2R5B/PPP2CB	2.78133928864011
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/860	69/9376	2.05406134142231	CACNA1C/KCNMA1/EDNRA/GUCY1A2/ADCY5/GNAQ/PRKACB/PPP3CA/PPP3CB/PDE1A/PLCB4/NPR1/ITPR1	2.79256063253396
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/860	69/9376	2.05406134142231	CACNA1C/CREB5/MAOB/CAMK2G/ADCY5/CAMK2D/PRKCA/PRKACB/PPP3CA/CREB3L2/PPP3CB/PRKCB/CAMK2A	2.79256063253396
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	18/860	110/9376	1.78401691331924	LTBP1/BMPR1A/THSD4/THBS1/TGFBR1/INHBA/ACVR1/BMPR1B/NEO1/MAPK1/TF/TGFB2/SMAD1/BMP8A/SMAD2/RGMA/BMPR2/PPP2CB	2.62840729421328
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	21/860	138/9376	1.65904954499494	AKT3/ITGA5/WIPF3/MAPK10/ARHGEF7/PTK2/NFATC1/ARHGEF28/PIP5K1A/GNAQ/PIP5K1C/PIK3CB/ARHGEF12/RPS6KA2/MAP2K3/MAPK1/GSK3B/WIPF2/DOCK1/MAP2K1/ACTR3	2.47848141236558
Human Diseases	Cancer: specific types	hsa05218	Melanoma	13/860	73/9376	1.94151003504301	AKT3/MITF/EGFR/PIK3CB/PDGFD/IGF1/MAPK1/IGF1R/PDGFC/DDB2/PDGFA/BRAF/MAP2K1	2.56620832957823
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/860	37/9376	2.35725958516656	CCDC6/TCF7L2/PPARG/TCF7L1/MAPK1/DDB2/BRAF/MAP2K1	2.62863707591041
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	11/860	59/9376	2.03263697280252	AKT3/TCF7L2/EGFR/PIK3CB/TCF7L1/MAPK1/GSK3B/CTNNA1/DDB2/BRAF/MAP2K1	2.52844008054559
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	13/860	75/9376	1.88973643410853	CREB5/ALB/ADCY5/GNAQ/PRKCA/PRKACB/ADCY2/CREB3L2/TTF2/PLCB4/PRKCB/ADCY9/ITPR1	2.4583528736209
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	21/860	142/9376	1.61231575499509	AKT3/MITF/MAPK10/PLCG2/NFATC1/RELB/TGFBR1/FOSL1/PIK3CB/PPARG/PPP3CA/MAPK1/ITGB3/PPP3CB/MAP3K14/TGFB2/GAB2/ATP2A2/CTSK/ITPR1/MAP2K1	2.3363704707381
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	21/860	142/9376	1.61231575499509	AKT3/BMPR1A/MAPK10/PTK2/SDC4/CAV1/PIK3CB/MAP3K5/BCL2/MGST1/ACVR1/BMPR1B/ITGB3/MEF2A/ASS1/ITGAV/PRKAA2/CAV2/PDGFA/GSTM2/BMPR2	2.3363704707381
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/860	76/9376	1.86487148102815	CAMK2G/ADCY5/GNAQ/MYLK/CAMK2D/PRKCA/PRKACB/ADCY2/PLCB4/PRKCB/ADCY9/ITPR1/CAMK2A	2.40565827632196
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	33/860	250/9376	1.43910697674419	WIPF3/LDLR/EGFR/PIP5K1A/RAB31/TGFBR1/CAV1/PIP5K1C/PARD3/PSD/AGAP1/RUFY2/IGF1R/ITCH/GRK4/VPS45/CBL/ACAP3/CBLB/PSD3/EEA1/WIPF2/HSPA6/EPN2/EHD1/CAV2/ARFGEF2/ASAP3/ARFGAP1/SMAD2/RUFY1/ACTR3/DNM3	2.23623348888538
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	10/860	53/9376	2.05704256252742	ATP2B4/GNAQ/ESR1/PRKCA/PRKACB/PLCB4/PRKCB/SLC8A2/ADCY9/DNM3	2.45227745204042
Organismal Systems	Digestive system	hsa04970	Salivary secretion	15/860	93/9376	1.75843960990248	ATP2B4/KCNMA1/GUCY1A2/RYR3/ADCY5/GNAQ/PRKCA/PRKACB/PRKG1/ADCY2/PLCB4/PRKCB/SLC12A2/ADCY9/ITPR1	2.33579832498089
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	21/860	144/9376	1.58992248062016	AKT3/RORA/KCND3/MAPK10/GNAQ/PIK3CB/MAP3K5/PRKCA/MCU/ATXN2/ATXN1/PSMD14/DAB1/PSMD1/AMBRA1/PLCB4/MTOR/PRKCB/ATP2A2/PSMD11/ITPR1	2.26696769872428
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/860	70/9376	1.86897009966777	AKT3/PIK3CB/GAB1/PAK3/MAPK1/TGFB2/RAP1B/PTPN11/RAPGEF1/PAK1/BRAF/MAP2K1	2.31893922335354
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	16/860	103/9376	1.69356513885753	AKT3/SERPINE1/GNA14/MAPK10/GNAO1/GNAQ/TGFBR1/PIK3CB/MAPK1/TGFB2/PPP2R2C/GNAL/CFLAR/PLCB4/SMAD2/PPP2CB	2.24912076741812
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	26/860	193/9376	1.46870707314134	AKT3/PTK2/PLCG2/CCL21/ADCY5/GNAQ/PIK3CB/PRKACB/PARD3/RASGRP2/GNB1/ADCY2/MAPK1/GSK3B/GNB5/GRK4/RAP1B/CCL14/PLCB4/PRKCB/GNG12/PAK1/BRAF/ADCY9/MAP2K1/GNG4	2.09076348791737
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/860	149/9376	1.53656937724364	CACNA1C/MAPK10/CNR1/GNAO1/ADCY5/GNAQ/PRKCA/PRKACB/GNB1/ADCY2/MAPK1/GNB5/DAGLB/PLCB4/PRKCB/MT-ND4/GNG12/ADCY9/ITPR1/NAPEPLD/GNG4	2.09800150112117
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	9/860	49/9376	2.00246796392976	GALNT17/GALNT18/EOGT/GALNT13/ST3GAL3/GALNT16/XXYLT1/GALNT7/GALNT15	2.23570548217203
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	12/860	73/9376	1.79216310927047	AKT3/PLCG2/EGFR/PIK3CB/PRKCA/FHIT/MAPK1/DDB2/PRKCB/RASSF1/BRAF/MAP2K1	2.15914381550018
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	28/860	214/9376	1.42647250597696	AKT3/MAPK10/PTK2/PLCG2/GNAO1/NFATC1/GNAQ/PIK3CB/BCL2/PRKCA/GNB1/PAK3/PPP3CA/BTRC/MAP2K3/MAPK1/GNB5/PPP3CB/DCAF1/TRAF5/MTOR/PRKCB/NFATC4/GNG12/PAK1/ITPR1/MAP2K1/GNG4	2.00548684931746
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	13/860	83/9376	1.70759316335108	AUTS2/SFMBT2/ASXL1/PHC3/LCOR/KDM2A/AEBP2/FOXK2/ASXL2/USP45/YAF2/FOXK1/L3MBTL1	2.05760375226188
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	20/860	144/9376	1.51421188630491	AKT3/FOXO1/MAPK10/TCF7L2/ACACB/MAP3K5/CPT1A/TCF7L1/C5AR1/MAP2K3/ACACA/GSK3B/MAP3K14/TRA2A/TRAF3/SREBF1/PRKAB2/NOX4/PRKAA2/CAMKK2	1.97602528272506
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	9/860	51/9376	1.92393980848153	PLCG2/PRKCA/PRKACB/TJP2/ATP6V0A1/SLC12A2/SEC61A2/ADCY9/ATP6V1H	2.10242922363897
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	10/860	59/9376	1.84785179345684	PTGER3/AKT3/ADCY5/PIK3CB/PRKACB/INSR/PRKG1/ADCY2/NPR1/ADCY9	2.07598847746147
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/860	52/9376	1.88694096601073	LDLR/ADCY5/PLA2G4C/PRKACB/IGF1/INSR/ADCY2/IGF1R/ADCY9	2.03803806590498
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	12/860	77/9376	1.6990637269707	AKT3/MAPK10/EGFR/TGFBR1/PIK3CB/MAPK1/TGFB2/DDB2/MTOR/SMAD2/BRAF/MAP2K1	1.95731644151536
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	12/860	77/9376	1.6990637269707	AKT3/TGFBR1/PIK3CB/MAPK1/TGFB2/CBL/ABL1/PTPN11/DDB2/GAB2/BRAF/MAP2K1	1.95731644151536
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	28/860	224/9376	1.36279069767442	AKT3/CREB5/IL15/MAPK10/NFATC1/RELB/ADCY5/TGFBR1/FOSL1/PIK3CB/PRKACB/PPP3CA/ADCY2/CREB3L2/TLN2/MAPK1/PPP3CB/MAP3K14/TGFB2/ANAPC7/SMAD2/NFATC4/KAT2A/MAD1L1/DLG1/ADCY9/MAP2K1/MMP7	1.74638174753022
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	20/860	150/9376	1.45364341085271	AKT3/TCF7L2/EGFR/TGFBR1/PIK3CB/GAB1/BCL2/TCF7L1/FZD3/WNT5A/MAPK1/GSK3B/CTNNA1/TGFB2/DDB2/MTOR/SMAD2/LRP6/BRAF/MAP2K1	1.77979732207092
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	31/860	253/9376	1.33585807519073	CD44/AKT3/FOXO1/ITGA5/FNBP1/PRKCE/ACTN1/MAPK10/PLCE1/PTK2/PLCG2/EGFR/VCL/SEPTIN9/PIK3CB/RPTOR/BCL2/CTTN/MYL9/TLN2/BTRC/MAPK1/GSK3B/CAPN2/ACTN4/TRAF5/PLCB4/MTOR/DOCK1/ITPR1/ACTR3	1.7209341600665
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	7/860	39/9376	1.95682766845558	MTHFD1L/DMGDH/BHMT2/FTCD/AHCYL2/AMT/MTR	1.90273973124794
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/860	17/9376	2.56525307797538	MYH11/PCDH7/MYH9/DAG1	2.05263316174722
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	16/860	116/9376	1.5037690457097	ACTN1/PTK2/PLCG2/VCL/PIK3CB/PRKCA/CTNND1/MYL9/MSN/CTNNA1/RAP1B/ACTN4/ARHGAP35/PTPN11/PRKCB/RAPGEF4	1.73489029385816
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	30/860	248/9376	1.31882970742686	AKT3/MAPK10/TCF7L2/MYO6/KLC1/PIK3CB/DYNC1I1/TUBB6/BCL2/FLNA/DYNC2LI1/TCF7L1/MYL9/PAK3/TUBA1A/MAP2K3/AHNAK2/MAPK1/DYNC1H1/EXOC2/ARHGEF26/RHOJ/RAB9B/SNX9/FYCO1/KPNA1/EXOC4/PAK1/MAP2K1/ACTR3	1.617014233703
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	18/860	137/9376	1.43242233916143	AKT3/MAPK10/DAB2IP/PIK3CB/MAP3K5/BCL2/TUBA1A/SPTAN1/MAPK1/LMNA/CAPN2/MAP3K14/NGF/CFLAR/TRAF1/CTSK/ITPR1/MAP2K1	1.62021615887763
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	7/860	41/9376	1.86137266023823	THBS1/EGFR/MAPK1/DAPK3/RASSF1/BRAF/MAP2K1	1.75647870091229
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/860	102/9376	1.49639762881897	ATP2B4/KCNMA1/ADCY5/GNAQ/PRKCA/ADCY2/RAP1B/PLCB4/PRKCB/ATP2A2/SLC12A2/ADCY9/ITPR1/SLC4A4	1.60181839177712
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	19/860	148/9376	1.39962287869265	AKT3/PGR/TCF7L2/EGFR/ESR1/PIK3CB/IGF1/TCF7L1/FZD3/WNT5A/MAPK1/IGF1R/GSK3B/DDB2/MTOR/LRP6/BRAF/MAP2K1/NCOA3	1.55720018321453
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	11/860	76/9376	1.57796817625459	SORBS1/APOA2/APOC3/CPT1A/PPARG/FABP3/PLIN4/APOA1/ME1/ME3/SLC27A4	1.6076306794215
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	9/860	59/9376	1.66306661411116	CTPS1/NT5E/DPYD/UCK2/NT5C2/ENTPD1/CMPK1/CTPS2/ENTPD4	1.62353687437735
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	10/860	68/9376	1.60328317373461	AKT3/TCF7L2/PIK3CB/TCF7L1/PER2/MAPK1/ZBTB16/MTOR/BRAF/MAP2K1	1.58658929242918
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	26/860	216/9376	1.31231696813092	AKT3/MAPK10/PTK2/CAMK2G/LDLR/NFATC1/PIK3CB/CAMK2D/MAP3K5/BCL2/PRKCA/PPARG/PPP3CA/MAP2K3/MAPK1/GSK3B/PPP3CB/TRAF3/RAP1B/HSPA4/APOB/APOA1/HSPA6/PLCB4/ITPR1/CAMK2A	1.47567852160841
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/860	69/9376	1.58004718570947	AKT3/MAPK10/PLCG2/PLA2G4C/PIK3CB/PRKCA/MAP2K3/MAPK1/GAB2/MAP2K1	1.536738776169
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/860	44/9376	1.73446088794926	CREB5/DYNC1I1/PRKACB/DYNC2LI1/CREB3L2/DYNC1H1/ADCY9	1.55176046880545
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	10/860	70/9376	1.55747508305648	AKT3/MAPK10/ACACB/CPT1A/PTPN11/PRKAB2/PRKAA2/MTOR/CAMKK2/LEPR	1.48768160910967
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	6/860	36/9376	1.81705426356589	PYGB/PGM2L1/GPI/GBE1/GYG1/GYS1	1.5607945872671
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	5/860	28/9376	1.9468438538206	HADH/HACD1/ELOVL5/ELOVL6/MECR	1.59446527590948
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	6/860	37/9376	1.76794468887492	GNAQ/LAMA4/PRKCA/APOA1/PLCB4/PRKCB	1.48729683215122
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	6/860	38/9376	1.72141982864137	PIK3CB/PRKCA/IGF1/INSR/MAPK1/PRKCB	1.41602191886724
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/860	14/9376	2.33621262458472	FUT8/ST3GAL3/ST3GAL2	1.58990914565763
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/860	47/9376	1.62375061850569	CACNA1C/PRKCE/MAPK10/PIK3CB/INSR/MAPK1/MTOR	1.36225813211904
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	51/860	480/9376	1.15837209302326	CACNA1C/UBE2G1/MAPK10/MT-ATP8/PRKN/RYR3/CAMK2G/KLC1/GNAQ/CAMK2D/TUBB6/MAP3K5/BCL2/UBE2G2/PRKCA/MCU/ATXN2/DNAH7/PPP3CA/TUBA1A/FZD3/ATXN1/MAP2K3/WNT5A/MAPK1/GSK3B/PPP3CB/CAPN2/PSMD14/SNCAIP/PSMD1/AMBRA1/MAP3K10/NOX4/PLCB4/MTOR/PRKCB/ATP2A2/SPG11/MT-ND4/DNAL1/WDR41/LRP6/ZFYVE1/BRAF/PSMD11/MFN2/ITPR1/MAP2K1/CSNK1E/CAMK2A	1.1319283188553
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/860	15/9376	2.18046511627907	ST6GALNAC3/ST3GAL2/ST8SIA1	1.45396751065001
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	11/860	85/9376	1.41088919288646	CTPS1/NT5E/ADK/UCK2/NT5C2/ENTPD1/AK4/AMPD3/CMPK1/CTPS2/ENTPD4	1.20926083942923
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/860	23/9376	1.89605662285136	LARGE1/B3GALNT2/CRPPA/ST3GAL3	1.36722799522028
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	13/860	104/9376	1.36279069767442	PLPP1/SGMS2/DGKI/PLA2G4C/DGKH/LCLAT1/MBOAT1/PCYT1A/LPCAT1/DGKE/PISD/PLPP2/SELENOI	1.18223316501863
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	23/860	201/9376	1.24752979289599	PBX1/FOXO1/MITF/WT1/ETV6/PTK2/FUT8/MEIS1/AFF1/ZEB1/IGF1/PPARG/BCL6/JMJD1C/PER2/IGF1R/ZBTB16/NSD2/SMAD1/DDB2/PDGFA/TRAF1/DOT1L	1.12730000299365
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	19/860	163/9376	1.27082322727921	AKT3/CREB5/MAPK10/HSPG2/NFATC1/TGFBR1/PIK3CB/BCL2/PRKCA/CREB3L2/MAP2K3/MAPK1/TRAF3/TGFB2/DDB2/PRKCB/NFATC4/BRAF/MAP2K1	1.10839922420306
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	5/860	32/9376	1.70348837209302	HIBCH/ACACB/ACACA/BCKDHB/PCCA	1.26672556375625
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/860	32/9376	1.70348837209302	RPTOR/ATG10/ATG7/MTOR/PPP2CB	1.26672556375625
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	17/860	144/9376	1.28708010335917	AKT3/BMPR1A/MEIS1/PIK3CB/INHBA/IGF1/ACVR1/BMPR1B/FZD3/WNT5A/MAPK1/IGF1R/GSK3B/SMAD1/SMAD2/BMPR2/MAP2K1	1.10319803472741
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	11/860	87/9376	1.37845495856723	CACNB2/CACNA1C/TPM1/TPM4/CACNG4/TPM2/CACNA2D1/ASPH/CASQ2/ATP2A2/SLC8A2	1.12695450010147
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	18/860	155/9376	1.26607651912978	ITGA5/THBS1/PLA2R1/DYNC1I1/TUBB6/THBS3/STX18/ATP6V0A1/TUBA1A/ITGB3/DYNC1H1/ITGB5/THBS2/ITGAV/EEA1/STX12/SEC61A2/ATP6V1H	1.06145216181886
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	26/860	235/9376	1.20621474517566	CREB5/ZNF516/MT-ATP8/CNR1/ADCY5/RPTOR/MAP3K5/PRKACB/CPT1A/PPARG/RPS6KA2/PRKG1/ADCY2/CREB3L2/MAP2K3/PRKAB2/SLC25A20/PRKAA2/MTOR/BMP8A/NDUFAF5/NPR1/MT-ND4/ARID1B/SMARCA4/ADCY9	1.01735805958255
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	22/860	196/9376	1.22373042240152	AKT3/RCAN1/MAPK10/TCF7L2/PLCG2/NFATC1/PIK3CB/TCF7L1/GNB1/PPP3CA/MAPKAPK2/MAPK1/GSK3B/GNB5/PPP3CB/TRAF3/MTOR/NFATC4/GNG12/ITPR1/MAP2K1/GNG4	1.0058860265206
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	24/860	217/9376	1.20578716107598	CACNA1C/AKT3/CREB5/PGR/EGFR/ADCY5/ESR1/PIK3CB/BCL2/PRKCA/PRKACB/MGST1/BCL6/RPS6KA2/ADCY2/CREB3L2/AR/MAPK1/MTOR/GSTM2/PRKCB/KPNA1/ADCY9/MAP2K1	0.974633086971825
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/860	52/9376	1.46762075134168	LDLR/APOA2/APOC3/APOB/NCEH1/APOA1/OSBPL5	1.07451220336338
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	11/860	90/9376	1.33250645994832	AKT3/NFATC1/EGFR/PIK3CB/PPP3CA/MAP2K3/MAPK1/PPP3CB/PTPN11/MTOR/MAP2K1	1.00721930166682
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/860	17/9376	1.92393980848153	TXNRD1/KYAT1/MTR	1.21163121608466
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/860	71/9376	1.38198493285293	MAPK10/PLCG2/EGFR/ADAM17/ATP6V0A1/MAP3K14/PTPN11/PAK1/ATP6V1H	1.02667799985069
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/860	91/9376	1.31786353181702	AKT3/DAPP1/PLCG2/NFATC1/PIK3CB/PPP3CA/MAPK1/GSK3B/PPP3CB/PRKCB/MAP2K1	0.968249952021346
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	22/860	200/9376	1.19925581395349	MYH11/MYO1D/WIPF3/MYH9/MAPK10/MYO6/MYO1E/TUBB6/ARHGEF12/CTTN/PAK3/TUBA1A/MAPK1/ABL1/PTPN11/MYO5A/WIPF2/GNA12/SEC24A/F2R/PAK1/ACTR3	0.905141203358656
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	8/860	63/9376	1.3844222960502	HADH/PRDM2/CAMKMT/KMT2C/EHMT1/NSD2/NSD1/DOT1L	0.972861638935506
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/860	18/9376	1.81705426356589	ACACB/ACACA/MECR	1.10258649857315
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	12/860	103/9376	1.27017385414315	PPP2R3A/PABPN1/SMG1/SMG6/ACIN1/PPP2R2C/RNGTT/CSTF3/DDX19B/PPP2R5C/PPP2R5B/PPP2CB	0.87613057825787
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	7/860	55/9376	1.38756871035941	PLPP1/SGMS2/CERS4/SPHK1/CERS6/B4GALT5/PLPP2	0.91604294865525
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/860	94/9376	1.27580405739733	MAPK10/FOSL1/USP25/MAPK1/GSK3B/TRAF3/MAPK6/TRAF5/TNFAIP3/CSF3/TRAF3IP2	0.85400582524664
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/860	19/9376	1.72141982864137	BCKDHB/OGDH/AMT	1.00026160363752
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	12/860	105/9376	1.24598006644518	PLCG2/CCL21/RELB/BCL2/MAP3K14/TRAF3/TRAF5/CFLAR/ERC1/TNFAIP3/PRKCB/TRAF1	0.805468036487739
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	6/860	47/9376	1.39178624443345	ACACB/ACYP2/ACACA/ACYP1/ME1/ME3	0.855652854999095
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	7/860	57/9376	1.33888208894329	HADH/HACD1/CPT1A/ELOVL5/ACACA/ELOVL6/MECR	0.815489596447806
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	39/860	388/9376	1.09585231359386	CACNA1C/AKT3/MAPK10/MT-ATP8/RYR3/BACE2/KLC1/GNAQ/PIK3CB/TUBB6/MAP3K5/MCU/SLC39A11/INSR/ADAM17/PPP3CA/TUBA1A/FZD3/IDE/WNT5A/MAPK1/GSK3B/PPP3CB/CAPN2/PSMD14/PSMD1/AMBRA1/NOX4/PLCB4/MTOR/ATP2A2/MT-ND4/LRP6/BRAF/PSMD11/ITPR1/MAP2K1/CSNK1E/SLC39A9	0.612779133669929
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/860	21/9376	1.55747508305648	CHSY3/CHST11/UST	0.812699981349528
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	8/860	70/9376	1.24598006644518	DMD/SGCD/DTNA/CAV1/ABL2/EIF4G3/DAG1/ABL1	0.656423994865791
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	5/860	41/9376	1.32955190017016	NBN/RAD51B/BABAM2/RBBP8/UIMC1	0.672009828282656
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	6/860	51/9376	1.28262653898769	PLPP1/PLA2G4C/PAFAH1B1/LPCAT1/PLPP2/SELENOI	0.643117970985804
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	12/860	112/9376	1.16810631229236	AKT3/LAMA3/MAPK10/GNAO1/LDLR/LAMA4/BCL2/MAP2K3/MAPK1/TGFB2/ITGA6/HSPA6	0.568736101648293
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	18/860	174/9376	1.12782678428228	UBE2G1/MAPK10/PRKN/NPLOC4/MAP3K5/BCL2/UBE2G2/CAPN2/SIL1/UGGT2/HSPA6/MAN1A2/SEC24A/UBQLN1/SEC61A2/WFS1/UBE4B/SEC23A	0.540844491399341
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	27/860	268/9376	1.09836862200625	MAOB/UBE2G1/MAPK10/MT-ATP8/PRKN/RYR3/CAMK2G/ADCY5/KLC1/CAMK2D/TUBB6/MAP3K5/UBE2G2/PRKACB/MCU/SLC39A11/TUBA1A/PSMD14/SNCAIP/PSMD1/GNAL/MT-ND4/PSMD11/MFN2/ITPR1/SLC39A9/CAMK2A	0.519193816086702
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	7/860	62/9376	1.23090772693173	ADAM17/NUMB/ATXN1/TLE2/ITCH/TLE4/KAT2A	0.579673212479215
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	7/860	63/9376	1.21136950904393	TCF7L2/TCF7L1/FZD3/WNT5A/GSK3B/DDB2/PTCH2	0.534915089739265
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	4/860	33/9376	1.3214940098661	VTI1A/STX8/STX18/STX16	0.587900349587392
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/860	43/9376	1.26771227690644	PLPP1/APOB/APOA1/PLPP2/SLC27A4	0.55912501146821
NA	NA	hsa04082	Neuroactive ligand signaling	20/860	199/9376	1.09571111370808	GNAO1/P2RY14/ADCY5/GNAQ/PRKCA/PRKACB/GNB1/ADCY2/GRM7/GNB5/GNAL/GABBR1/HTR2A/ADRA2C/PLCB4/PRKCB/SLC1A2/GNG12/ADCY9/GNG4	0.433666205055587
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/860	54/9376	1.21136950904393	GCLC/KYAT1/BHMT2/MTAP/AHCYL2/MTR	0.494996019644059
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/860	44/9376	1.23890063424947	FUT8/MAN2A1/ST3GAL3/ALG13/MAN1A2	0.504746496761704
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	3/860	24/9376	1.36279069767442	EXT1/NDST1/EXTL2	0.565492112812919
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	8/860	75/9376	1.16291472868217	AKT3/REV3L/PIK3CB/MAP3K5/BCL2/MGST1/MAPK1/GSTM2	0.450135428939995
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/860	65/9376	1.17409660107335	PLPP1/DGKI/DGKH/LCLAT1/MBOAT1/DGKE/PLPP2	0.447575025218603
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	18/860	181/9376	1.08420917384042	AKT3/MAPK10/PLA2R1/CAMK2G/CAMK2D/BCL2/ARHGEF12/PPP3CA/ATP6V0A1/SPHK1/PLK3/MAPK1/PPP3CB/TGFB2/EEA1/KSR1/CAMK2A/ATP6V1H	0.363529672067142
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	16/860	160/9376	1.09023255813953	NRXN3/NCAM1/NLGN1/PTPRM/ALCAM/SDC4/PVR/PTPRS/ITGA8/SDC3/NEO1/ITGB8/NEGR1/CNTNAP1/ITGA6/ITGAV	0.365821364862864
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	11/860	108/9376	1.11042204995693	IPO5/ACIN1/NUP153/NUP98/NUP188/KPNA1/NUP205/DDX19B/XPO5/IPO7/RANGAP1	0.36676822887059
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	11/860	109/9376	1.10023469170045	RORA/MAPK10/NFATC1/TGFBR1/IL1RAP/PPP3CA/MAPK1/PPP3CB/IL6R/MTOR/SMAD2	0.334486630661295
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	20/860	205/9376	1.06364152013613	CREB5/HDAC9/ACTN1/HDAC4/GSN/PIK3CB/PRKACB/CREB3L2/RASA2/MAPKAPK2/MAPK1/TRAF3/ACTN4/TRAF5/YWHAG/TRAF1/KAT2A/MAD1L1/DLG1/SND1	0.292769725726609
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	20/860	205/9376	1.06364152013613	AKT3/MAPK10/MT-ATP8/CAMK2G/TGFBR1/PLN/PIK3CB/CAMK2D/PRKCA/INSR/GSK3B/TGFB2/GYS1/PLCB4/MTOR/PRKCB/ATP2A2/SMAD2/MT-ND4/CAMK2A	0.292769725726609
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	31/860	323/9376	1.04635322917417	TNC/CD44/TPM1/ITGA5/PRKCE/THBS1/ABCC1/FOXP1/HDAC4/TIMP3/SLC7A1/PLCG2/EGFR/PIK3CB/RPTOR/ZEB1/BCL2/PRKCA/HOXD10/GLS/FZD3/MAPK1/ITGB3/TGFB2/ABL1/MTOR/PDGFA/PRKCB/BMPR2/RASSF1/MAP2K1	0.269402755131349
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/860	26/9376	1.25796064400716	ABCC1/APOB/APOA1	0.418553866782658
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/860	16/9376	1.36279069767442	MAOB/AOC3	0.46152501721853
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/860	16/9376	1.36279069767442	ST3GAL2/ST8SIA1	0.46152501721853
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	5/860	48/9376	1.13565891472868	HADH/HIBCH/BCKDHB/OXCT1/PCCA	0.299427528628323
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/860	27/9376	1.21136950904393	HACD1/ELOVL5/ELOVL6	0.349509253337737
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/860	49/9376	1.1124822021832	CREB5/MAOB/ADCY5/PRKACB/CREB3L2	0.250857967652103
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	7/860	71/9376	1.07487716999672	AKT3/MAPK10/ESR1/PIK3CB/MAPK1/GSK3B/MAP2K1	0.201250720944837
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	7/860	71/9376	1.07487716999672	AKT3/EGFR/PIK3CB/GLS/MAPK1/MTOR/MAP2K1	0.201250720944837
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	15/860	158/9376	1.03503090962614	GSK3B/TGFB2/CDC14A/ABL1/ANAPC7/PDS5A/PDS5B/DBF4B/YWHAG/CDC14B/SMAD2/MAD1L1/PPP2R5C/PPP2R5B/PPP2CB	0.141116775245055
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	5/860	50/9376	1.09023255813953	THBS1/THBS3/TGFB2/THBS2/CSF3	0.203290743424172
Organismal Systems	Digestive system	hsa04978	Mineral absorption	6/860	61/9376	1.072359893252	ATP2B4/MT1G/HEPH/TF/SLC8A2/STEAP2	0.18017247434001
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/860	117/9376	1.02500496919102	BAZ2B/GATAD2B/BICRAL/SMARCA1/GATAD2A/INO80D/EP400/MTA3/ARID1B/SMARCA4/INO80	0.0864876805120105
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	21/860	227/9376	1.00858518594406	AKT3/MAPK10/MT-ATP8/PTK2/EGFR/ABL2/PIK3CB/MAP3K5/PTPRJ/MGST1/MAPK1/MAP3K14/PRKD1/ABL1/PTPN11/NOX4/PTPN1/GSTM2/MT-ND4/BRAF/MAP2K1	0.0416095345838385
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	4/860	41/9376	1.06364152013613	MAOB/AOC3/DMGDH/AMT	0.129775391967838
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/860	30/9376	1.09023255813953	PIGZ/PIGQ/PGAP1	0.157299755099319
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/860	75/9376	1.0175503875969	SERPINE1/THBS1/BCL2/IGF1/ZNF385A/COP1/DDB2	0.0484919400038137
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	25/860	275/9376	0.991120507399577	CACNA1C/CREB5/NCAM1/MAPK10/MT-ATP8/RYR3/KLC1/CAV1/PIK3CB/TUBB6/PRKACB/MCU/PPP3CA/TUBA1A/CREB3L2/MAPK1/GSK3B/PPP3CB/PSMD14/PSMD1/HSPA6/CAV2/MT-ND4/PSMD11/ITPR1	-0.0474927127442444
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	3/860	31/9376	1.05506376594149	HIBCH/AOC3/DPYD	0.097582994714711
NA	NA	hsa04981	Folate transport and metabolism	3/860	31/9376	1.05506376594149	ABCC1/BHMT2/MTR	0.097582994714711
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/860	20/9376	1.09023255813953	LBR/LSS	0.128366056250262
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/860	20/9376	1.09023255813953	GMDS/UAP1	0.128366056250262
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/860	133/9376	0.983668473509355	PLCG2/NFATC1/PIK3CB/PRKCA/PPP3CA/MAPK1/PPP3CB/PTPN11/PRKCB/PAK1/BRAF/MAP2K1	-0.0602786005592733
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	3/860	32/9376	1.02209302325581	MAPK10/BCL2/BIRC6	0.0397814639857332
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	14/860	157/9376	0.972181898977929	AKT3/MAPK10/PIK3CB/MAP3K5/PPARG/INSR/GSK3B/ITCH/SREBF1/MLXIP/IL6R/PRKAB2/PRKAA2/LEPR	-0.111699810439735
Human Diseases	Substance dependence	hsa05034	Alcoholism	17/860	191/9376	0.970364056982832	CREB5/MAOB/HDAC9/HDAC4/GNAO1/ADCY5/PRKACB/GNB1/CREB3L2/MAPK1/GNB5/CAMKK2/CAMKK1/GNG12/BRAF/MAP2K1/GNG4	-0.131496105870924
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/860	90/9376	0.969095607235142	KCNN2/LDLR/ADCY5/PRKACB/ADCY2/NCEH1/ADCY9/SLC4A4	-0.0936147252714882
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/860	56/9376	0.973421926910299	FUT8/MAN2A1/MGAT5/ALG13/MAN1A2	-0.0633908515984651
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/860	103/9376	0.952630390607361	COL12A1/COL4A5/COL18A1/COL7A1/COL4A6/COL8A1/COL4A2/SLC8A2/COL27A1	-0.153612063612319
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/860	22/9376	0.991120507399577	MAOB/FTCD	-0.013250059995075
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/860	34/9376	0.961969904240766	POLR2J3/CRCP/POLR1A	-0.0705933811538527
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/860	46/9376	0.948028311425682	PSME4/PSMD14/PSMD1/PSMD11	-0.112285055710249
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/860	23/9376	0.948028311425682	GLS/ASS1	-0.0792998408421605
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	2/860	23/9376	0.948028311425682	GLS/SLC4A4	-0.0792998408421605
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	4/860	48/9376	0.908527131782946	AKT3/PIK3CB/PLCB4/PRKCB	-0.201899705017955
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/860	73/9376	0.896081554635234	BICD1/MAP1B/AFF4/NUP153/ELL/KAT2A	-0.283243268968133
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/860	37/9376	0.883972344437461	GLS/RIMKLB/ASS1	-0.224713533487572
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	3/860	37/9376	0.883972344437461	GPI/GMDS/UAP1	-0.224713533487572
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	13/860	156/9376	0.908527131782946	AKT3/LDLR/EGFR/PIK3CB/MAPK1/GSK3B/TRAF3/PPP2R2C/CFLAR/YWHAG/BRAF/MAP2K1/PPP2CB	-0.366105432360876
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/860	12/9376	0.908527131782946	COQ4	-0.100755614237616
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/860	12/9376	0.908527131782946	NCAM1	-0.100755614237616
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/860	38/9376	0.860709914320685	NT5E/NT5C2/NMNAT1	-0.273402263941452
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	17/860	205/9376	0.904095292115712	CD44/AKT3/MAPK10/PLCG2/RELB/PIK3CB/BCL2/MAP2K3/MAP3K14/TRAF3/PSMD14/PSMD1/TRAF5/ENTPD1/DDB2/TNFAIP3/PSMD11	-0.44118988614844
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	7/860	88/9376	0.86723044397463	SERPINE1/CLU/VWF/CFH/MASP1/C5AR1/F2R	-0.397645226299196
Human Diseases	Infectious disease: viral	hsa05162	Measles	11/860	136/9376	0.881805745554036	AKT3/MAPK10/PIK3CB/BCL2/MSN/GSK3B/TRAF3/RAB9B/CBLB/HSPA6/TNFAIP3	-0.441211548671259
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/860	27/9376	0.807579672695952	HADH/OXCT1	-0.318175905442748
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/860	28/9376	0.778737541528239	ST3GAL3/ST8SIA1	-0.372601359212531
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	15/860	187/9376	0.874518094764333	MAPK10/BCL2/MCU/ANTXR1/MAPK1/TRAF3/GBP2/TRAF5/DNM1L/ERBIN/PLCB4/TNFAIP3/MFN2/ITPR1/TP53BP1	-0.550788443040853
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	3/860	42/9376	0.778737541528239	MAOB/HADH/KYAT1	-0.45668370729519
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	3/860	42/9376	0.778737541528239	GCLC/TF/ATG7	-0.45668370729519
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	8/860	105/9376	0.830653377630122	MITF/RABGEF1/MAPK10/PRKN/RRAS2/MRAS/AMBRA1/MFN2	-0.554529858363519
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/860	15/9376	0.726821705426356	AK4	-0.336471073517903
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/860	43/9376	0.760627366143862	HADH/CPT1A/CYP2U1	-0.49993682843602
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	2/860	30/9376	0.726821705426356	ABCC1/MTR	-0.476223657190723
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	2/860	31/9376	0.70337584396099	PCCA/AMT	-0.52567188161031
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/860	31/9376	0.70337584396099	IMMP2L/SEC61A2	-0.52567188161031
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	8/860	109/9376	0.800170684873053	AKT3/MAPK10/PIK3CB/MAP2K3/MAPK1/TRAF3/CTSK/MAP2K1	-0.666837331369452
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	3/860	45/9376	0.726821705426356	ABCC1/ABCB8/ABCB10	-0.583721095756386
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	15/860	195/9376	0.838640429338104	AKT3/HDAC9/HDAC4/PLCG2/VWF/PIK3CB/PRKCA/C5AR1/MAPK1/ITGB3/ATG7/PLCB4/MTOR/PRKCB/MAP2K1	-0.723575876027422
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/860	17/9376	0.641313269493844	CYP7B1	-0.470372675240448
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	1/860	17/9376	0.641313269493844	CA5B	-0.470372675240448
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	2/860	33/9376	0.660747004933051	BCKDHB/OGDH	-0.62037533601791
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	7/860	100/9376	0.763162790697674	CD44/ITGA5/ITGB3/IL6R/ITGA3/ITGA6/CSF3	-0.756635306191393
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	1/860	18/9376	0.605684754521964	MAN2C1	-0.532114799754153
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/860	18/9376	0.605684754521964	MTR	-0.532114799754153
NA	NA	hsa03272	Virion - Hepatitis viruses	3/860	48/9376	0.681395348837209	HSPG2/LDLR/EGFR	-0.703226938664234
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	24/860	308/9376	0.849531863485352	CREB5/MAPK10/MT-ATP8/KLC1/GNAQ/TUBB6/MAP3K5/DNAH7/PPARG/POLR2J3/TUBA1A/CREB3L2/RCOR1/PSMD14/PSMD1/AMBRA1/MAP3K10/PLCB4/MTOR/SLC1A2/MT-ND4/DNAL1/PSMD11/ITPR1	-0.853259598421625
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	19/860	250/9376	0.828576744186047	MITF/VPS13A/RPTOR/DEPTOR/ATP6V0A1/AP3S2/NCOA7/AP4E1/OSBPL5/HGSNAT/CLN8/SLC17A5/MTOR/SPG11/CTSK/WDR7/AP3B1/ENTPD4/ATP6V1H	-0.873004633784846
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/860	19/9376	0.573806609547124	HGSNAT	-0.590924822508625
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	2/860	35/9376	0.622990033222591	GMDS/PFKFB3	-0.71007987664091
NA	NA	hsa04382	Cornified envelope formation	16/860	217/9376	0.803858107383989	COL4A5/LAMA3/DST/PPP2R3A/COL7A1/COL4A6/TCHH/PPP2R2C/ITGA6/KAZN/COL4A2/PPP2R5C/PPP2R5B/PPP2CB/SLC27A4/PKP2	-0.928951919474969
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	5/860	78/9376	0.69886702444842	ZCCHC7/DCP1B/PARN/TENT4B/PNPT1	-0.848648569247469
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	12/860	168/9376	0.778737541528239	MAPK10/CAMK2G/PYGB/PLA2G4C/CAMK2D/BCL2/CAPN2/TRAF5/CFLAR/DNM1L/TNFAIP3/CAMK2A	-0.919595328837219
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/860	79/9376	0.690020606417427	UNC13B/ATP6V0A1/SLC1A2/DNM3/ATP6V1H	-0.879208730418544
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	2/860	37/9376	0.58931489629164	MAOB/AOC3	-0.795383655367169
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	4/860	66/9376	0.660747004933051	RORA/NFATC1/TGFB2/SMAD2	-0.878896743254846
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/860	21/9376	0.519158361018826	DPYD	-0.70098198629711
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	2/860	38/9376	0.573806609547124	GPI/UAP1	-0.836543658211017
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	28/860	368/9376	0.829524772497472	MT-ATP8/PRKN/KLC1/TUBB6/MAP3K5/BCL2/MCU/ATXN2/DNAH7/PPP3CA/TUBA1A/MAP2K3/PPP3CB/PSMD14/PSMD1/AMBRA1/NUP153/NUP98/NUP188/MTOR/SPG11/SLC1A2/MT-ND4/DNAL1/UBQLN1/WDR41/PSMD11/NUP205	-1.0602005781321
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/860	82/9376	0.664775950085082	MGST1/DPYD/UCK2/CMPK1/GSTM2	-0.96885279871119
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/860	23/9376	0.474014155712841	NLN	-0.802563758873382
Organismal Systems	Sensory system	hsa04742	Taste transduction	5/860	86/9376	0.633856138453218	CACNA1C/PRKACB/PDE1A/GABBR1/PLCB4	-1.08395228094968
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	10/860	154/9376	0.707943219571126	GPHN/CTPS1/GCLC/MTHFD1L/COQ4/RDH13/AK4/NMNAT1/CMPK1/CTPS2	-1.1612671269613
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	11/860	168/9376	0.713842746400886	AKT3/IL15/EGFR/PIK3CB/BCL2/IL6R/PTPN11/MTOR/LEPR/PDGFA/CSF3	-1.18930647132902
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	3/860	59/9376	0.554355538037052	GCLC/MGST1/GSTM2	-1.09117274412735
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	7/860	116/9376	0.657898957497995	HIBCH/GPI/OGDH/PCCA/ME1/ME3/AMT	-1.17813466946815
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	1/860	26/9376	0.419320214669052	PLA2G4C	-0.942181589165401
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	2/860	44/9376	0.495560253699789	TAF1/MNAT1	-1.06577446130392
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/860	28/9376	0.38936877076412	GPHN	-1.02829023758654
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/860	28/9376	0.38936877076412	ATP6V0A1	-1.02829023758654
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	5/860	93/9376	0.586146536634159	MAPK10/NFATC1/PPP3CA/MAPK1/PPP3CB	-1.27456189510167
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	3/860	63/9376	0.519158361018826	PTGIS/PLA2G4C/CYP2U1	-1.2168711070457
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	3/860	63/9376	0.519158361018826	POLR2J3/MNAT1/DDB2	-1.2168711070457
Organismal Systems	Sensory system	hsa04744	Phototransduction	1/860	29/9376	0.375942261427426	GNB1	-1.06955885595674
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	5/860	95/9376	0.573806609547124	IL15/ATP6V0A1/TGFB2/CTSK/ATP6V1H	-1.32674715185184
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/860	30/9376	0.363410852713178	OGDH	-1.10974706948077
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	1/860	30/9376	0.363410852713178	PLA2G4C	-1.10974706948077
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	11/860	180/9376	0.66625322997416	AKT3/ITGA5/PIK3CB/BCL2/EIF2B3/ITGB3/TRAF3/TRAF5/PTPN11/SRSF4/MTOR	-1.43671584023026
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	1/860	31/9376	0.351687921980495	GPI	-1.14892675793533
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	2/860	50/9376	0.436093023255814	IL15/MAP3K14	-1.27046235735808
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3/860	68/9376	0.480984952120383	ALDH1A2/RDH5/RDH13	-1.36497047062955
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	5/860	100/9376	0.545116279069767	CCL21/ACKR3/IL6R/CCL14/TNFRSF10D	-1.45323906020264
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	10/860	173/9376	0.630192230138459	AKT3/PIK3CB/PRKCA/PABPN1/MAPK1/TRAF3/NUP98/PRKCB/KPNA1/MAP2K1	-1.56009631009957
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/860	54/9376	0.403789836347976	REV3L/FANCL	-1.39623571637171
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/860	36/9376	0.302842377260982	CRPPA	-1.33175958141893
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/860	36/9376	0.302842377260982	PRIM2	-1.33175958141893
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/860	73/9376	0.448040777317617	MAOB/MGST1/GSTM2	-1.50443681120229
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	19/860	298/9376	0.695114718276885	BMPR1A/IL15/CCL21/TGFBR1/IL1RAP/INHBA/ACKR3/ACVR1/BMPR1B/TGFB2/IL6R/NGF/CCL14/LEPR/BMP8A/TNFRSF10D/BMPR2/TNFRSF8/CSF3	-1.69967755604154
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	2/860	56/9376	0.38936877076412	HSPA6/HSF1	-1.45640481547473
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	14/860	238/9376	0.641313269493844	MAPK10/PLCG2/VWF/EGFR/PIK3CB/PRKCA/MASP1/ADAM17/C5AR1/MAPK1/TRAF3/IL6R/PRKCB/CSF3	-1.78112848612195
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	3/860	78/9376	0.419320214669052	ITGA5/MAPK10/MAPK1	-1.63646332026373
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	3/860	78/9376	0.419320214669052	MAPK1/TGFB2/PRKCB	-1.63646332026373
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/860	44/9376	0.247780126849894	APTX	-1.58928144732579
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	1/860	44/9376	0.247780126849894	PTPRN2	-1.58928144732579
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2/860	66/9376	0.330373502466526	RDH5/CYP7B1	-1.73478954183788
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/860	46/9376	0.237007077856421	HEPH	-1.64844947546603
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	2/860	70/9376	0.311495016611296	MGST1/GSTM2	-1.83734884786584
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	1/860	50/9376	0.218046511627907	MAOB	-1.76171339095216
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	2/860	72/9376	0.302842377260982	MAPK10/TRAF3	-1.88703265255808
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	2/860	75/9376	0.290728682170543	ASS1/MTR	-1.95972550467709
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2/860	79/9376	0.276008242566971	MGST1/GSTM2	-2.05349093218553
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	3/860	99/9376	0.330373502466526	CFH/MASP1/C5AR1	-2.12845016938385
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	2/860	82/9376	0.265910380034033	HSPA4/HSPA6	-2.12164008814217
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/860	138/9376	0.395011796427368	MT-ATP8/ATP6V0A1/LHPP/MT-ND4/ATP6V1H	-2.27517343520314
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	1/860	67/9376	0.162721277334259	GPI	-2.18561155714222
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	1/860	83/9376	0.131353320257775	FAR1	-2.52592981419272
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	17/860	370/9376	0.500917661847894	PTGER3/OXTR/EDNRA/CNR1/P2RY14/GRID1/AVPR1A/GRM7/GRP/C5AR1/GABBR1/HTR2A/ADRA2C/LEPR/CALCRL/RXFP1/F2R	-3.11260584892385
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/860	243/9376	0.358924298975979	RBM25/TRA2A/ACIN1/SRSF4/SNRNP70/HSPA6/PRPF18/PRPF40B	-3.21753115893429
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	2/860	143/9376	0.152480078061473	ACTN1/ACTN4	-3.24536504354691
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	3/860	183/9376	0.178726648875334	NVL/WDR43/MDN1	-3.56534600613173
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	11/860	449/9376	0.267094836069819	CAMK2G/CAMK2D/PRKACB/GNB1/PRKG1/PDE1A/GNAL/ANO2/NCALD/SLC8A2/CAMK2A	-5.05749220674938
Genetic Information Processing	Translation	hsa03010	Ribosome	1/860	222/9376	0.04910957469097	DAP3	-4.55636539769866