category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	65/1273	122/9376	3.92412398748278	FYN/PPP2R5C/PTPRC/CBLB/RASGRP1/ITK/CD3E/PIK3R1/IFNG/PRKCQ/CARD11/PPP2R2B/CD3D/CD247/CD3G/GRAP2/MAPK1/AKT3/NFATC2/CD8A/SOS1/NCK2/NFKB1/KRAS/MAP2K1/NFATC1/PPP2R2A/PPP2R5A/PIK3CB/PPP2CA/GSK3B/TNF/LCK/LAT/PPP3CC/RAF1/MALT1/RELA/PAK2/PPP2R2D/PTPN11/PPP2R5E/CD40LG/NCK1/ZAP70/PIK3CA/CD8B/PPP3CB/NFATC3/ICOS/MAPK8/PPP3CA/LCP2/PAK1/NFKBIA/GRB2/PPP2R3C/DLG1/SOS2/RHOA/VAV1/AKT2/MAP3K14/MAPK14/MAP2K2	12.8851023248929
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	76/1273	205/9376	2.73054240990171	CD44/HLA-B/RUNX3/HLA-A/HLA-C/TNFAIP3/B2M/CASP8/BCL2/CD3E/TRAF3/PIK3R1/JAK1/STAT1/HLA-DPB1/ITGAL/CD3D/CD247/VIM/CD3G/HLA-F/RELB/AKT3/CD58/HLA-E/CDKN1A/TAPBP/NFKB1/SIN3A/NFKB2/PIK3CB/RIPK1/TNF/HLA-DRB5/USP7/SNW1/CDKN1B/STAT3/TAP1/CCND3/MAP2K3/PLCG2/TAB2/PSMD12/FAS/BCL2L11/CYCS/HLA-DPA1/RELA/CCND2/PSMD7/IRF9/PIK3CA/TRAF5/HLA-DRB1/PDIA3/TAP2/MAPK8/ISG15/MAP2K4/DDB2/IRF3/MDM2/JAK3/NFKBIA/PSMD14/BAX/CASP3/CDK6/TRADD/AKT2/MAP3K14/EIF2AK2/NCOR2/MAPK14/HLA-DQA2	9.92950848515134
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	77/1273	214/9376	2.65012370513395	HLA-B/CXCR4/HLA-A/HLA-C/B2M/CASP8/BCL2/CD3E/PIK3R1/CALM1/GNB1/APOBEC3G/GNG2/CD3D/CD247/ITPR1/CD3G/HLA-F/MAPK1/AKT3/NFATC2/HLA-E/PTK2B/RAC2/TNFRSF1B/TAPBP/NFKB1/KRAS/MAP2K1/NFATC1/PIK3CB/RIPK1/TNF/TAP1/CUL1/MAP2K3/PPP3CC/PRKCB/PLCG2/CUL4A/TAB2/CGAS/RAF1/FAS/CYCS/RELA/PAK2/AP1G1/GNB5/PIK3CA/GNAI3/TRAF5/PPP3CB/PDIA3/APOBEC3H/NFATC3/APOBEC3C/TAP2/MAPK8/PPP3CA/CRK/RPS6KB1/PAK1/IRF3/DDB1/NFKBIA/BAX/CASP3/TRADD/ITPR3/AKT2/FBXW11/LIMK2/MAPK14/CFL1/GNAO1/MAP2K2	9.67843564847124
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	50/1273	109/9376	3.37856828844671	RORA/TGFB1/IL2RG/CD3E/IFNG/PRKCQ/JAK1/STAT1/HLA-DPB1/CD3D/CD247/CD3G/SMAD3/MAPK1/STAT5B/NFATC2/GATA3/NFKB1/HSP90AA1/NFATC1/HLA-DRB5/LCK/IL4R/LAT/STAT3/IL21R/HSP90AB1/IL2RB/PPP3CC/STAT5A/TBX21/HLA-DPA1/RELA/ZAP70/RARA/SMAD2/PPP3CB/HLA-DRB1/NFATC3/MAPK8/PPP3CA/RUNX1/IRF4/AHR/JAK3/NFKBIA/IL27RA/IFNGR1/MAPK14/HLA-DQA2	9.900023204103
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	77/1273	227/9376	2.49835450616152	CCL5/HLA-B/CXCR4/HLA-A/HLA-C/B2M/CASP8/PIK3R1/CALM1/JAK1/AKAP13/GNB1/GNG2/ITPR1/HLA-F/MAPK1/AKT3/NFATC2/HLA-E/PTK2B/RAC2/CDKN1A/SOS1/TAPBP/NFKB1/KRAS/MAP2K1/NFATC1/PIK3CB/RIPK1/GSK3B/TNF/STAT3/TAP1/PPP3CC/PRKCB/CGAS/RAF1/IL10RA/PTGER4/FAS/CYCS/GNAS/ARHGEF1/RELA/GNB5/ROCK1/PIK3CA/GNAI3/TRAF5/PPP3CB/PDIA3/NFATC3/TAP2/PPP3CA/CRK/RPS6KB1/RHEB/CREB1/IRF3/PTGER2/MDM2/NFKBIA/GRB2/BAX/CASP3/SOS2/RHOA/CDK6/TRADD/ATF4/GNA13/ITPR3/AKT2/MAPK14/GNAO1/MAP2K2	9.05769335393767
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	76/1273	224/9376	2.49893390191898	HLA-B/HLA-A/HLA-C/TGFB1/IL2RG/B2M/CD3E/PIK3R1/JAK1/KAT2B/HLA-DPB1/ITGAL/ETS1/CD3D/CD3G/HLA-F/SMAD3/MAPK1/RELB/STAT5B/AKT3/NFATC2/HLA-E/CDKN1A/NFKB1/KRAS/MAP2K1/NFATC1/NFKB2/PIK3CB/CREBBP/TNF/HLA-DRB5/LCK/BUB3/CCND3/IL2RB/ZFP36/PPP3CC/XPO1/TRRAP/TLN1/STAT5A/HLA-DPA1/RELA/EP300/FOSL1/VDAC1/POLB/CCND2/ELK4/PTTG1/ANAPC16/PIK3CA/SMAD2/MAP3K3/PPP3CB/HLA-DRB1/NFATC3/MAPK8/PPP3CA/MAP2K4/CREB1/JAK3/NFKBIA/BAX/DLG1/ITGB2/ATF4/AKT2/TSPO/MAP3K14/RAN/TBPL1/HLA-DQA2/MAP2K2	8.99964557450082
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	41/1273	90/9376	3.35529370690408	EML4/RASGRP1/CD3E/PIK3R1/IFNG/PRKCQ/JAK1/STAT1/CD3D/CD247/CD3G/MAPK1/AKT3/NFATC2/NFKB1/KRAS/MAP2K1/NFATC1/PIK3CB/LCK/LAT/STAT3/MAP2K3/PPP3CC/RAF1/RELA/PTPN11/ZAP70/PIK3CA/MAP3K3/PPP3CB/NFATC3/PPP3CA/RPS6KB1/BATF/NFKBIA/AKT2/IFNGR1/MAPK14/TICAM1/MAP2K2	8.89874797915027
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	79/1273	253/9376	2.29983016061776	CD44/FNBP1/CCL5/FOXO1/DIAPH1/BCL2/SEPTIN6/UBC/PIK3R1/PRKCQ/ACTN4/ITPR1/MAPK1/AKT3/CYTH1/NFKB1/ITGA5/CAST/PIK3CB/CAPN2/MYL9/RIPK1/UBE2N/RPS6KA5/GSK3B/TNF/ATG16L1/UBE2D2/ITGB1/CUL1/TNIP1/MAP1LC3B/ARPC5L/PLCG2/TAB2/CGAS/MALT1/PRKCE/TLN1/CYCS/RELA/VDAC1/ARPC2/SEPTIN9/ATG5/ROCK1/PIK3CA/PIK3C3/TRAF5/SQSTM1/ATG12/MAPK8/CRK/RPS6KB1/IRF3/ACTR3/HCLS1/MDM2/NFKBIA/UBE2V1/HK1/BAX/CAPNS1/SEPTIN7/RHOA/CALCOCO2/MYL12B/TRADD/ARF6/ITPR3/CYTH3/ELMO2/MYL12A/AKT2/FBXW11/BECN1/CASP4/GLMN/MAPK14	8.30720549326323
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	59/1273	163/9376	2.66595983595102	STAT4/TGFB1/CASP8/BCL2/TRAF3/PIK3R1/JAK1/STAT1/BRAF/YWHAZ/SMAD3/MAPK1/STAT5B/AKT3/NFATC2/PTK2B/CDKN1A/SOS1/YWHAQ/NFKB1/KRAS/MAP2K1/NFATC1/PIK3CB/CREBBP/TNF/STAT3/MAP2K3/PRKCB/TAB2/RAF1/FAS/STAT5A/CYCS/RELA/EP300/SLC10A1/DDX3X/PIK3CA/NFATC3/MAPK8/MAP2K4/YWHAB/CREB1/DDB2/IRF3/DDB1/JAK3/NFKBIA/GRB2/BAX/CASP3/SOS2/ATF4/AKT2/IFIH1/MAPK14/TICAM1/MAP2K2	8.50422445463262
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	68/1273	205/9376	2.44311689306995	HLA-B/HLA-A/HLA-C/SP100/CASP8/TRAF3/PIK3R1/JAK1/KAT2B/ACTN4/REL/YWHAZ/TRAF1/HLA-F/MAPK1/STAT5B/RASA2/HLA-E/CDKN1A/MAPKAPK2/YWHAQ/NFKB1/KRAS/SND1/HDAC4/NFKB2/PIK3CB/RBL2/CREBBP/USP7/SNW1/CDKN1B/STAT3/CCND3/GTF2A1/STAT5A/PKM/RELA/EP300/UBR4/POLB/CCND2/CHD4/IRF9/DDX3X/PIK3CA/PMAIP1/TRAF5/YWHAB/GTF2B/CREB1/IRF3/UBE3A/DDB1/MDM2/JAK3/NFKBIA/GRB2/BAX/DLG1/CASP3/RHOA/CDK6/TRADD/ATF4/YWHAG/EIF2AK2/TBPL1	8.28031798169985
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	41/1273	93/9376	3.2470584260362	STAT4/RUNX3/IL2RG/CD3E/IFNG/PRKCQ/JAK1/STAT1/HLA-DPB1/CD3D/CD247/CD3G/MAPK1/STAT5B/NFATC2/GATA3/NFKB1/NFATC1/HLA-DRB5/LCK/IL4R/LAT/IL2RB/PPP3CC/STAT5A/TBX21/HLA-DPA1/RELA/MAML1/ZAP70/PPP3CB/HLA-DRB1/NFATC3/NOTCH1/MAPK8/PPP3CA/JAK3/NFKBIA/IFNGR1/MAPK14/HLA-DQA2	8.63154590011938
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	62/1273	180/9376	2.53692938814698	CCL5/HLA-B/HLA-A/HLA-C/B2M/SP100/ZC3HAV1/CASP8/BCL2/TRAF3/PIK3R1/IFNG/JAK1/STAT1/SRSF7/HLA-DPB1/BIRC3/HLA-F/AKT3/HLA-E/BIRC2/TAPBP/NFKB1/ITGA5/SRSF2/PIK3CB/TNFSF14/SRPK1/TNF/HLA-DRB5/SRSF4/TAP1/TAB2/CGAS/FAS/CYCS/HLA-DPA1/PILRB/RELA/PTPN11/IRF9/PPP1CC/PIK3CA/TRAF5/HLA-DRB1/PDIA3/TAP2/RHEB/IRF3/SRSF3/NFKBIA/BAX/POU2F1/CASP3/TRADD/AKT2/NXF1/IFIH1/EIF2AK2/IFNGR1/HLA-DQA2/TICAM1	8.25215937171017
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	44/1273	105/9376	3.08640257359817	CBLB/IRF1/CASP8/PIK3R1/CALM1/STAT1/CYLD/ITPR1/MAPK1/RELB/AKT3/NFATC2/LSP1/MAPKAPK2/NFKB1/KRAS/NFATC1/NFKB2/PIK3CB/PLK3/TNF/PPP3CC/PLCG2/RAF1/MALT1/RRAS2/RELA/KSR1/BCL3/PTPN11/IRF9/PIK3CA/PPP3CB/NFATC3/MAPK8/PPP3CA/PAK1/MDM2/NFKBIA/RHOA/ITPR3/AKT2/MAP3K14/MAPK14	8.52131047815799
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	65/1273	196/9376	2.4425669718005	HLA-B/HLA-A/HLA-C/CLEC2B/CASP8/TRAF3/UBC/PIK3R1/CALM1/JAK1/GNB1/STAT1/GNG2/ITPR1/HLA-F/MAPK1/AKT3/NFATC2/HLA-E/CDKN1A/MAPKAPK2/NFKB1/KRAS/MAP2K1/NFATC1/PIK3CB/PREX1/GSK3B/CREBBP/STAT3/MAP1LC3B/ZFP36/PPP3CC/PLCG2/RAF1/FAS/CYCS/RELA/EP300/GNB5/IRF9/PIK3R5/PIK3CA/PIK3C3/PPP3CB/NFATC3/MAPK8/PPP3CA/MAP2K4/CREB1/IRF3/NFKBIA/BAX/CASP3/ANGPT2/CDK6/TRADD/ITPR3/AKT2/BECN1/EIF2AK2/IFNGR1/MAPK14/TICAM1/MAP2K2	8.08946127344056
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	55/1273	157/9376	2.58019323429784	HLA-B/HLA-A/FOXO1/HLA-C/TGFB1/ZFP36L2/PIK3R1/CALM1/ETS1/ITPR1/HLA-F/SMAD3/MAPK1/AKT3/NFATC2/HLA-E/CDKN1A/MAPKAPK2/NFKB1/KRAS/MAP2K1/NFATC1/RASSF5/PIK3CB/CAPN2/RBL2/SERPINE1/CCND3/MAP2K3/PPP3CC/RAF1/HIPK1/TRPM7/RRAS2/RELA/VDAC1/CCND2/MCU/PPP1CC/PIK3CA/SMAD2/PPP3CB/NFATC3/SQSTM1/SIRT1/PPP3CA/RHEB/MDM2/RBBP4/CDK6/ITPR3/AKT2/FBXW11/MAPK14/MAP2K2	7.91398161998262
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	50/1273	138/9376	2.66857930029486	PIK3R1/WIPF1/RPS6KA3/MAPK1/AKT3/NFATC2/CD8A/PTK2B/RAC2/NFKB1/ITGA5/MAP2K1/NFATC1/PIK3CB/GSK3B/TNF/LCK/LAT/ITGB1/ARHGEF7/MAP2K3/PIP5K1A/ARPC5L/TAB2/FYB1/ARHGEF1/RELA/ARPC2/ZAP70/ROCK1/PIK3CA/CD8B/NFATC3/MAPK8/MAP2K4/CRK/LCP2/IRF3/ACTR3/NFKBIA/WIPF2/ITGA4/RHOA/VAV1/ARF6/ELMO2/AKT2/MAPK14/TICAM1/MAP2K2	7.82662158703808
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	73/1273	248/9376	2.16800547348149	PTPRC/AHNAK/CASP8/BCL2/TUBA4A/RHOH/BIRC3/MAPK1/AKT3/CYTH1/DYNC1H1/FLNA/KLC1/BIRC2/CYFIP2/NFKB1/HSP90AA1/MAP2K1/PIK3CB/MYL9/RIPK1/TUBB4B/TNF/HSP90AB1/MAP2K3/RALA/ARPC5L/DYNLT1/TAB2/RAF1/KPNA4/KPNA1/DNM2/CYCS/TXN/GAPDH/RELA/RAB5A/ABI1/PLEKHM1/ARPC2/DYNC1LI1/EXOC2/PIK3CA/PIK3C3/DYNLL2/MAPK8/MAP2K4/TUBA1A/PAK1/KIF5B/ACTR3/FYCO1/DYNLT3/NFKBIA/BAX/DYNC1LI2/TNFRSF10A/GCC2/CASP3/RHOA/MYL12B/TRADD/ARF6/CYTH3/ELMO2/MYL12A/AKT2/ANXA2/CASP4/MAPK14/S100A10/MAP2K2	7.38856032005325
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	48/1273	133/9376	2.65814575716589	FYN/HLA-B/HLA-A/HLA-C/PIK3R1/IFNG/ITGAL/CD48/CD247/BRAF/KLRK1/MAPK1/NFATC2/HLA-E/PTK2B/RAC2/SOS1/KRAS/MAP2K1/NFATC1/SH2D1A/PIK3CB/TNF/LCK/LAT/PPP3CC/PRKCB/PLCG2/RAF1/FAS/HCST/PTPN11/ZAP70/PIK3CA/PRF1/PPP3CB/PPP3CA/KLRD1/LCP2/PAK1/GRB2/TNFRSF10A/ITGB2/CASP3/SOS2/VAV1/IFNGR1/MAP2K2	7.63341666186685
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	57/1273	173/9376	2.42671037874213	CCL5/CASP8/TRAF3/PIK3R1/IFNG/JAK1/STAT1/HLA-DPB1/DNAJB1/MAPK1/HNRNPUL1/AKT3/NUP98/MX1/NFKB1/MAP2K1/PIK3CB/CREBBP/TNF/HLA-DRB5/MX2/CCND3/ADAR/PRKCB/XPO1/RAF1/KPNA1/KPNA5/FAS/CYCS/HLA-DPA1/RELA/EP300/VDAC1/IRF9/DNAJC3/NXT1/PIK3CA/RAB11A/HLA-DRB1/KPNA2/IRF3/NFKBIA/BAX/TNFRSF10A/CASP3/CDK6/CALCOCO2/TRADD/AKT2/NXF1/IFIH1/EIF2AK2/IFNGR1/HLA-DQA2/TICAM1/MAP2K2	7.50708065164521
Human Diseases	Infectious disease: viral	hsa05162	Measles	48/1273	136/9376	2.59951018899312	IL2RG/TNFAIP3/CBLB/CASP8/BCL2/CD3E/TRAF3/PIK3R1/JAK1/STAT1/CD3D/CD3G/MSN/HSPA8/STAT5B/AKT3/SLAMF1/MX1/NFKB1/PIK3CB/GSK3B/MX2/CDKN1B/STAT3/CCND3/IL2RB/ADAR/TAB2/FAS/STAT5A/CYCS/RELA/CCND2/IRF9/HSPA1B/PIK3CA/MAPK8/IRF3/HSPA6/JAK3/NFKBIA/BAX/CASP3/CDK6/TRADD/AKT2/IFIH1/EIF2AK2	7.44727515525892
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	35/1273	83/9376	3.1058404868492	SFMBT2/EZH2/JARID2/ASXL1/RYBP/KDM2A/KDM2B/CREBBP/PCGF5/USP7/UBE2D2/OGT/PHF1/LCOR/PHC3/YAF2/MAX/EP300/PHF19/AEBP2/AUTS2/FOXK2/FBRS/BCOR/USP16/SUZ12/ASXL2/TEX10/YY1/FOXK1/EED/L3MBTL3/RBBP4/SFMBT1/RBBP7	7.63771536293889
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	48/1273	137/9376	2.58053566206616	CASP8/BCL2/TUBA4A/PIK3R1/MCL1/TRAF1/ITPR1/BIRC3/LMNA/MAP3K5/SPTAN1/MAPK1/AKT3/BIRC2/ERN1/NFKB1/KRAS/MAP2K1/CFLAR/PIK3CB/CAPN2/RIPK1/TNF/PARP4/RAF1/EIF2AK3/FAS/BCL2L11/CYCS/RELA/DDIT3/CTSW/LMNB1/PIK3CA/PRF1/PMAIP1/MAPK8/TUBA1A/NFKBIA/BAX/TNFRSF10A/CASP3/TRADD/ATF4/ITPR3/AKT2/MAP3K14/MAP2K2	7.38633532700737
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	32/1273	77/9376	3.06089511431224	TGFB1/PIK3R1/BRAF/SMAD3/MAPK1/STAT5B/AKT3/CDKN1A/SOS1/NFKB1/KRAS/MAP2K1/PIK3CB/BCR/CDKN1B/RAF1/STAT5A/RELA/PTPN11/PIK3CA/CRK/RUNX1/DDB2/MDM2/NFKBIA/CBL/GRB2/BAX/SOS2/CDK6/AKT2/MAP2K2	7.19714162802492
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	42/1273	119/9376	2.59951018899312	CCL5/TNFAIP3/IRF1/CASP8/TRAF3/PIK3R1/CYLD/TRAF1/BIRC3/MAP3K5/MAPK1/AKT3/TNFRSF1B/BIRC2/NFKB1/MAP2K1/CFLAR/PIK3CB/RIPK1/RPS6KA5/TNF/MAP2K3/TAB2/FAS/RELA/ITCH/BCL3/PIK3CA/TRAF5/MAPK8/MAP2K4/CREB1/CCL20/NFKBIA/IL18R1/CASP3/DNM1L/TRADD/ATF4/AKT2/MAP3K14/MAPK14	6.95988847136177
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	50/1273	156/9376	2.360666304107	CASP8/TRAF3/PIK3R1/IFNG/JAK1/STAT1/PPP2R2B/BRAF/YWHAZ/MAPK1/AKT3/CDKN1A/SOS1/YWHAQ/MX1/NFKB1/KRAS/MAP2K1/LDLR/PPP2R2A/CFLAR/PIK3CB/RIPK1/PPP2CA/GSK3B/TNF/MX2/STAT3/RAF1/FAS/CYCS/RELA/PPP2R2D/PIAS1/IRF9/PIK3CA/YWHAB/IRF3/NFKBIA/GRB2/BAX/CASP3/SOS2/CDK6/TRADD/AKT2/YWHAG/EIF2AK2/TICAM1/MAP2K2	6.7924334050321
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	42/1273	120/9376	2.57784760408484	BCL2/PIK3R1/CALM1/RPS6KA3/BRAF/ARHGDIB/RAPGEF1/MAP3K5/MAPK1/AKT3/RAP1A/SOS1/MAPKAPK2/RAP1B/NFKB1/KRAS/MAP2K1/PIK3CB/RPS6KA5/GSK3B/PLCG2/RAF1/RELA/PTPN11/PSEN1/PIK3CA/MAP3K3/MATK/ARHGDIA/MAPK8/CRK/ZNF274/NFKBIA/GRB2/BAX/SOS2/RHOA/ATF4/CAMK4/AKT2/MAPK14/MAP2K2	6.89478813078884
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	69/1273	250/9376	2.03281696779262	HLA-B/CXCR4/HLA-A/HLA-C/IL2RG/CBLB/ARAP2/SH3KBP1/WIPF1/CAPZA1/HLA-F/ACAP1/GRK5/SMAD3/HSPA8/VPS37B/SMAP2/CYTH1/HLA-E/ARFGEF1/IGF2R/LDLR/RAB11FIP1/IST1/GBF1/IL2RB/SMURF1/PIP5K1A/ARPC5L/RAB22A/MVB12B/DNM2/SMURF2/EHD1/USP8/SMAP1/ITCH/RAB5A/RAB11FIP3/ARFGAP3/CLTB/ARPC2/ARFGEF2/HSPA1B/AP2B1/SMAD2/RAB11A/GRK2/RAB35/IQSEC1/KIF5B/ACTR3/EPS15/HSPA6/MDM2/GRK6/RAB10/CBL/WIPF2/CHMP4A/VPS26A/RHOA/VPS4B/PRKCI/ARF6/CYTH3/SNX1/RABEP1/ARF4	6.56039602628513
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	62/1273	216/9376	2.11410782345582	CCL5/CASP8/BCL2/TRAF3/PIK3R1/CALM1/ITPR1/MAP3K5/MAPK1/HSPA8/AKT3/RAP1A/NFATC2/ERN1/RAP1B/HSPD1/NFKB1/KRAS/HSP90AA1/NFATC1/LDLR/NFE2L2/PIK3CB/HSPA4/GSK3B/TNF/STAT3/HSP90AB1/MAP2K3/PPP3CC/TAB2/EIF2AK3/TANK/FAS/CYCS/ARHGEF1/RELA/HSPA5/DDIT3/ERO1A/CD40LG/HSPA1B/PIK3CA/PPP3CB/NFATC3/MAPK8/PPP3CA/MAP2K4/ABCG1/IRF3/HSPA6/NFKBIA/BAX/POU2F1/TNFRSF10A/CASP3/RHOA/VAV1/ATF4/AKT2/MAPK14/TICAM1	6.56573398833193
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	39/1273	112/9376	2.56469532039053	TGFB1/CASP8/BCL2/IFNG/JAK1/STAT1/HLA-DPB1/BIRC3/MAPK1/HSPA8/AKT3/SOCS1/BIRC2/NFKB1/LDLR/TNF/HLA-DRB5/ITGB1/STAT3/MAP2K3/TAB2/IL10RA/CYCS/HLA-DPA1/RELA/CD40LG/HSPA1B/PIK3R5/GNAI3/HLA-DRB1/MAPK8/HSPA6/NFKBIA/CASP3/AKT2/IFNGR1/MAPK14/HLA-DQA2/GNAO1	6.60262211834124
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	51/1273	169/9376	2.22265812017459	BCL2/UBC/PIK3R1/PRKCQ/ITPR1/DDIT4/MAPK1/GABARAPL1/AKT3/OPTN/ERN1/KRAS/MAP2K1/CFLAR/PIK3CB/PPP2CA/ATG16L1/VMP1/MAP1LC3B/RAF1/RRAS2/EIF2AK3/TANK/DAPK2/PLEKHM1/ATG4B/RB1CC1/ATG5/PRKAA1/BIRC6/PIK3CA/PIK3C3/EPG5/SQSTM1/HMGB1/ATG12/MAPK8/RPS6KB1/RHEB/ATG2A/ATG101/GORASP2/RUBCN/IGBP1/CALCOCO2/TAX1BP1/ATG13/AKT2/ATG2B/BECN1/MAP2K2	6.3572053152814
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	45/1273	142/9376	2.33406724715931	FYN/TGFB1/PIK3R1/IFNG/JAK1/STAT1/CYLD/ITPR1/MAPK1/RELB/AKT3/NFATC2/JUND/SOCS1/FOSL2/NFKB1/MAP2K1/NFATC1/NFKB2/PIK3CB/TNF/LCK/PPP3CC/ATP2A3/PLCG2/TAB2/RELA/FOSL1/IRF9/ATP2A2/PIK3CA/PPP3CB/SQSTM1/MAPK8/PPP3CA/LCP2/CREB1/NFKBIA/GRB2/CAMK4/ITPR3/AKT2/MAP3K14/IFNGR1/MAPK14	6.34897883839784
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	82/1273	333/9376	1.8136722740022	HLA-B/HLA-A/FOXO1/PPP2R5C/HLA-C/IRF1/CASP8/TRAF3/PIK3R1/JAK1/STAT1/PPP2R2B/PATJ/HLA-F/MAPK1/AKT3/HLA-E/CDKN1A/OASL/SOS1/MX1/NFKB1/ITGA5/KRAS/MAP2K1/PPP2R2A/PPP2R5A/PIK3CB/PPP2CA/RBL2/GSK3B/CREBBP/TNF/MX2/CDKN1B/ITGB1/CCND3/ITGA1/TNC/RAF1/PTGER4/FAS/GNAS/PKM/RELA/EP300/PPP2R2D/UBR4/CCND2/CHD4/PPP2R5E/IRF9/PSEN1/MAML1/PIK3CA/NOTCH1/ISG15/RPS6KB1/RHEB/CREB1/IRF3/UBE3A/MDM2/ITGB7/NFX1/GRB2/PPP2R3C/BAX/DLG1/ITGA4/CASP3/SOS2/VWF/PRKCI/CDK6/TRADD/CSNK1A1/AKT2/EIF2AK2/TBPL1/TICAM1/MAP2K2	5.99228263751534
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	51/1273	174/9376	2.15878863396267	BCL2/DNAJA1/DNAJB1/DNAJC1/MAP3K5/HSPA8/HSPH1/ERN1/STT3B/UBE2G1/ERO1B/HSP90AA1/NFE2L2/CAPN2/PPP1R15A/SVIP/UBE2D2/HSP90AB1/CUL1/UBQLN1/EIF2AK3/HSPA5/DDIT3/SEC24B/ERO1A/NPLOC4/HSPA1B/UBXN4/DNAJC3/HYOU1/SAR1A/PLAA/CRYAB/PDIA3/VCP/MAPK8/DNAJB11/PDIA6/HSPA6/DERL1/BAX/SEC23B/ATF4/UBXN2A/EDEM1/SAR1B/MAN1A2/SSR3/DNAJC5/SEL1L/SEC13	6.11525620545057
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	32/1273	87/9376	2.70906808967865	TGFB1/BCL2/PIK3R1/BRAF/SMAD3/MAPK1/AKT3/RAC2/CDKN1A/SOS1/KRAS/MAP2K1/PIK3CB/GSK3B/RALGDS/RALA/RAF1/BCL2L11/CYCS/PIK3CA/SMAD2/PMAIP1/MAPK8/RPS6KB1/DDB2/GRB2/BAX/CASP3/SOS2/RHOA/AKT2/MAP2K2	6.34762746967457
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	62/1273	232/9376	1.96830728390714	CXCR4/DIAPH1/EZR/MYH9/PIK3R1/RGCC/PIP4K2A/ACTN4/ITGAL/SPATA13/BRAF/MSN/MAPK1/AKT3/PPP1R12A/RAC2/SOS1/MYH11/CYFIP2/ITGA5/KRAS/MAP2K1/IQGAP2/PIK3CB/MYL9/ITGB1/ARHGEF7/ITGA1/PIP5K1A/IQGAP1/ARPC5L/ARHGAP35/RAF1/RRAS2/F2R/ARHGEF1/PAK2/ARPC2/SLC9A1/ROCK1/PPP1CC/PIK3CA/CRK/PAK1/ITGAE/ACTR3/ITGB7/SSH1/ITGA4/ITGB2/SOS2/RHOA/VAV1/MYL12B/GNA13/PPP1R12C/MYL12A/AKT2/TIAM1/LIMK2/CFL1/MAP2K2	5.91924073552692
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	35/1273	103/9376	2.50276466416004	PPP2R5C/PPP2R2B/GSPT1/ETF1/FUS/SMG6/SMG1/PPP2R2A/PPP2R5A/PPP2CA/MSI2/WDR82/SRRM1/PAPOLA/ACIN1/RNPS1/CASC3/PPP2R2D/PABPC1/PPP2R5E/RNMT/PPP1CC/NXT1/CPSF6/RNGTT/HBS1L/PCF11/DDX39B/WDR33/PPP2R3C/EIF4A3/SSU72/RBM8A/NXF1/FIP1L1	6.07821947321177
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	28/1273	73/9376	2.82503847022996	EML4/PIK3R1/BRAF/STK4/MAPK1/STAT5B/AKT3/CDKN1A/SOS1/KRAS/MAP2K1/RASSF5/PIK3CB/STAT3/PRKCB/PLCG2/RAF1/STAT5A/PIK3CA/DDB2/KIF5B/JAK3/GRB2/BAX/SOS2/CDK6/AKT2/MAP2K2	6.2043867770693
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	31/1273	86/9376	2.65492610387475	CBLB/PIK3R1/BRAF/MAPK1/STAT5B/AKT3/CDKN1A/SOS1/NCK2/KRAS/MAP2K1/PIK3CB/GSK3B/CDKN1B/PRKCB/PLCG2/RAF1/STAT5A/PAK2/NCK1/PIK3CA/MAPK8/MAP2K4/CRK/RPS6KB1/PAK1/CBL/GRB2/SOS2/AKT2/MAP2K2	6.11078347511428
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	74/1273	300/9376	1.81676878764074	TGFB1/RASGRP1/DUSP2/DUSP16/PTPN7/RPS6KA3/BRAF/MAP3K5/STK4/MAPK1/RELB/HSPA8/RASA2/AKT3/RAP1A/NR4A1/JUND/FLNA/RAC2/SOS1/MAPKAPK2/RAP1B/NFKB1/KRAS/MAP2K1/NFATC1/DUSP5/MAP3K2/NFKB2/RPS6KA5/DUSP10/DUSP4/TNF/FLT3LG/MAP2K3/PPP3CC/PRKCB/TAB2/RAF1/RRAS2/FAS/MAX/RASGRF2/PPM1B/RELA/PAK2/DDIT3/RAPGEF2/DUSP8/ELK4/HSPA1B/MAP3K3/PPP3CB/NFATC3/RASA1/MAPK8/PPP3CA/MAP2K4/CRK/PAK1/HSPA6/GRB2/CASP3/SOS2/ANGPT2/TRADD/ATF4/AKT2/MAP3K14/NF1/TAOK1/MAP3K9/MAPK14/MAP2K2	5.69887901809445
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	30/1273	82/9376	2.69461422029774	HLA-B/HLA-A/HLA-C/B2M/IFNG/HLA-DPB1/HLA-F/HSPA8/CD8A/HLA-E/TAPBP/PSME1/HSP90AA1/HSPA4/PSME2/TNF/HLA-DRB5/HSP90AB1/TAP1/HLA-DPA1/HSPA5/HSPA1B/CD8B/HLA-DRB1/PDIA3/TAP2/KLRD1/CREB1/HSPA6/HLA-DQA2	6.10876416595474
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	43/1273	142/9376	2.23033092506334	CBLB/UBC/BIRC3/HERC1/UBR5/FBXW7/SOCS1/BIRC2/CUL3/UBE2S/UBE2G1/UBE2H/HUWE1/UBE2N/UBE2D2/CUL1/SMURF1/TRIP12/CUL4A/SMURF2/ITCH/PIAS1/HERC3/ANAPC16/SAE1/BIRC6/UBE2O/UBE4A/UBE2K/DDB2/UBE3A/DDB1/MDM2/UBE2L3/UBE3C/UBA6/UBE2A/CBL/UBE2R2/HERC4/UBE2I/FBXW11/TRIM37	5.85528579918789
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	53/1273	193/9376	2.02258953392297	CCL5/CXCR4/ITK/PIK3R1/GNB1/STAT1/GNG2/BRAF/GRK5/MAPK1/STAT5B/AKT3/RAP1A/PTK2B/RAC2/SOS1/CXCR3/RAP1B/NFKB1/KRAS/MAP2K1/PIK3CB/PREX1/GSK3B/CCL21/XCL2/STAT3/PRKCB/PLCG2/RAF1/RELA/GNB5/PIK3R5/ROCK1/PIK3CA/GNAI3/GRK2/CRK/DOCK2/PAK1/CCL20/XCL1/JAK3/GRK6/NFKBIA/GRB2/CXCR6/SOS2/RHOA/VAV1/AKT2/TIAM1/CCL14	5.68937586863162
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	27/1273	71/9376	2.80088069659117	IRF1/PIK3R1/STAT1/MAPK1/STAT5B/AKT3/SOCS1/SOS1/NFKB1/KRAS/MAP2K1/ESR2/PIK3CB/GSK3B/STAT3/RAF1/STAT5A/RELA/CCND2/SOCS4/PIK3CA/MAPK8/GRB2/SOS2/AKT2/MAPK14/MAP2K2	6.03716226928827
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	39/1273	125/9376	2.29796700706991	FYN/PPP2R5C/BCL2/PIK3R1/PPP2R2B/MAP3K5/MAPK1/AKT3/RAC2/ABCC1/NFKB1/KRAS/MAP2K1/PPP2R2A/PPP2R5A/PIK3CB/PPP2CA/TNF/PRKCB/RAF1/PRKCE/RELA/PPP2R2D/PPP2R5E/ROCK1/PIK3CA/GNAI3/MAPK8/ORMDL1/PPP2R3C/BAX/CERS5/RHOA/TRADD/GNA13/AKT2/ORMDL3/MAPK14/MAP2K2	5.79030232593973
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	34/1273	103/9376	2.43125710232689	CCL5/TGFB1/CASP8/CD3E/PIK3R1/IFNG/PPP2R2B/CD3D/CD247/CD3G/MAPK1/AKT3/NFKB1/PPP2R2A/CFLAR/PIK3CB/PPP2CA/TNF/SERPINE1/FAS/GNAS/RELA/PPP2R2D/PIK3CA/GNAI3/SMAD2/MAPK8/MAP2K4/NFKBIA/AKT2/IFNGR1/MAPK14/GNAO1/TICAM1	5.78899344522351
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	26/1273	69/9376	2.77532247230666	FYN/PIK3R1/MAPK1/AKT3/RAC2/SOS1/ALOX5AP/KRAS/MAP2K1/PIK3CB/TNF/LAT/MAP2K3/PLCG2/RAF1/INPP5D/PIK3CA/MAPK8/MAP2K4/LCP2/GRB2/SOS2/VAV1/AKT2/MAPK14/MAP2K2	5.86642954820133
NA	NA	hsa04517	IgSF CAM signaling	72/1273	299/9376	1.77357885804213	FYN/CD2/FOXO1/EZR/MYH9/CD96/TUBA4A/PIK3R1/MBP/PRKCQ/CASK/ACTN4/ITGAL/CD48/MSN/SPTAN1/MAPK1/AKT3/RAP1A/SLAMF1/NCK2/MYH11/RAP1B/ITGA5/MAP2K1/SH2D1A/PIK3CB/MYL9/TUBB4B/GSK3B/LCK/ITGB1/IQGAP1/ARPC5L/PRKCB/PLCG2/PPFIA1/ANK3/DOK2/ICAM3/CD226/SORBS1/SLAMF7/PAK2/RAPGEF2/ARPC2/CRTAM/PTPN11/INPP5D/NCK1/PIK3CA/DYNLL2/TIGIT/RASA1/MAPK8/TUBA1A/LCP2/PAK1/ACTR3/GRB2/ITGA4/ITGB2/RHOA/PRKCI/VAV1/MYL12B/ARF6/RAPGEF6/MYL12A/AKT2/MAPK14/MAP2K2	5.38822768455849
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	31/1273	91/9376	2.50905104322229	PIK3R1/CARD11/IFITM1/MAPK1/AKT3/NFATC2/RAC2/SOS1/NFKB1/KRAS/MAP2K1/NFATC1/PIK3CB/GSK3B/PPP3CC/PRKCB/PLCG2/RAF1/MALT1/RELA/INPP5D/PIK3CA/PPP3CB/NFATC3/PPP3CA/NFKBIA/GRB2/SOS2/VAV1/AKT2/MAP2K2	5.73337822410271
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	40/1273	133/9376	2.21512146430491	FOXO1/TGFB1/PIK3R1/BRAF/STK4/SMAD3/MAPK1/GABARAPL1/AKT3/CDKN1A/SOS1/BCL6/HOMER1/PRKAG2/KRAS/MAP2K1/PIK3CB/PLK3/RBL2/CREBBP/USP7/CDKN1B/STAT3/RAF1/BCL2L11/FBXO32/EP300/CCND2/PRKAA1/PIK3CA/ATG12/MAPK8/SIRT1/MDM2/GRB2/SOS2/CDKN2D/AKT2/MAPK14/MAP2K2	5.59391621136547
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	26/1273	70/9376	2.73567500841656	TGFB1/PIK3R1/ETS1/BRAF/RAPGEF1/MAPK1/AKT3/RAP1A/CDKN1A/SOS1/RAP1B/KRAS/MAP2K1/PIK3CB/CREBBP/RAF1/PAK2/EP300/PTPN11/PIK3CA/CRK/PAK1/GRB2/SOS2/AKT2/MAP2K2	5.77713912957245
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	25/1273	66/9376	2.78987835939918	STAT4/RORA/TGFB1/IL2RG/IFNG/STAT1/HLA-DPB1/SMAD3/GATA3/NFKB1/NFATC1/TNF/HLA-DRB5/IL4R/STAT3/IL21R/TBX21/HLA-DPA1/RELA/SMAD2/HLA-DRB1/IL18R1/IL18RAP/IFNGR1/HLA-DQA2	5.78359089126588
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	34/1273	108/9376	2.31869890314509	NUP153/NUP98/RANBP2/KPNB1/RANGAP1/SRRM1/XPO1/AHCTF1/SENP2/ACIN1/KPNA4/KPNA1/KPNA5/RNPS1/CASC3/XPO6/NUP88/TNPO3/NXT1/KPNA2/TPR/NUP58/XPO4/DDX39B/EIF4A3/RBM8A/TNPO1/POM121/UBE2I/POM121C/NUP54/NXF1/RAN/SEC13	5.46312868740479
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	53/1273	203/9376	1.92295458151297	FYN/DIAPH1/BCL2/PIK3R1/ACTN4/BRAF/BIRC3/RAPGEF1/MAPK1/AKT3/RAP1A/PPP1R12A/FLNA/RAC2/BIRC2/SOS1/RAP1B/ITGA5/MAP2K1/PIK3CB/CAPN2/MYL9/GSK3B/ITGB1/CCND3/ITGA1/PIP5K1A/ARHGAP35/PRKCB/TNC/RAF1/TLN1/PAK2/CCND2/ROCK1/PPP1CC/PIK3CA/MAPK8/CRK/PAK1/ITGB7/GRB2/ITGA4/SOS2/RHOA/VWF/VAV1/MYL12B/PARVG/ZYX/PPP1R12C/MYL12A/AKT2	5.26925932472128
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	53/1273	204/9376	1.91352833356438	CD44/TGFB1/EZR/PIK3R1/BRAF/ITPR1/MSN/MAPK1/AKT3/PPP1R12A/FLNA/CDKN1A/SOS1/ITGA5/KRAS/MAP2K1/PIK3CB/PDCD4/DDX5/TNF/ITGB1/STAT3/IQGAP1/PRKCB/PLCG2/RAF1/ANK3/RRAS2/FAS/ARHGEF1/PTPN11/SLC9A1/ROCK1/PPP1CC/PIK3CA/SMAD2/RPS6KB1/PAK1/HCLS1/MDM2/CBL/GRB2/CASP3/SOS2/RHOA/VAV1/ITPR3/PPP1R12C/AKT2/TIAM1/EIF4B/MAPK14/MAP2K2	5.228558879464
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	27/1273	77/9376	2.58263025270095	TGFB1/PIK3R1/JAK1/STAT1/BRAF/SMAD3/MAPK1/AKT3/RAC2/CDKN1A/NFKB1/KRAS/MAP2K1/PIK3CB/STAT3/RALGDS/RALA/RAF1/RELA/PIK3CA/SMAD2/MAPK8/RPS6KB1/DDB2/BAX/CDK6/AKT2	5.52692565205426
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	22/1273	56/9376	2.89350241274829	CASP8/CLK1/HSPA8/HSPD1/NFKB1/NFKB2/TNF/CYCS/RELA/HSPA1B/SAR1A/HSF1/VCP/HSPA6/HBS1L/NFKBIA/ITGB2/CASP3/RAB1B/BCL2L13/SAR1B/CLK4	5.63285848768391
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	52/1273	200/9376	1.91497250589159	FYN/EZR/MYH9/CASP8/TUBA4A/WIPF1/MYO1D/MAPK1/CYTH1/MYO1F/NCK2/MYH11/CYFIP2/NFKB1/RIPK1/TUBB4B/TNF/ITGB1/ARPC5L/TAB2/FAS/CYCS/F2R/ARHGEF1/GAPDH/RELA/PAK2/SEC24B/MYO1G/ABI1/ARPC2/PTPN11/NCK1/ROCK1/NCL/MAPK8/TUBA1A/PAK1/ACTR3/HCLS1/NFKBIA/BAX/WIPF2/TNFRSF10A/CASP3/RHOA/TRADD/ARF6/GNA13/CYTH3/CASP4/MAPK14	5.18409868316465
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	33/1273	105/9376	2.31480193019863	TNFAIP3/BCL2/TRAF3/PRKCQ/CARD11/CYLD/TRAF1/BIRC3/RELB/BIRC2/NFKB1/CFLAR/NFKB2/RIPK1/TNFSF14/TNF/CCL21/LCK/LAT/PRKCB/PLCG2/TAB2/MALT1/RELA/CD40LG/ZAP70/TRAF5/EDARADD/NFKBIA/TRADD/UBE2I/MAP3K14/TICAM1	5.36992985259887
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	24/1273	68/9376	2.59951018899312	PIK3R1/BRAF/MAPK1/STAT5B/AKT3/SOS1/NFKB1/KRAS/MAP2K1/PIK3CB/STAT3/RAF1/STAT5A/PIM1/RELA/RARA/PIK3CA/RPS6KB1/RUNX1/PER2/GRB2/SOS2/AKT2/MAP2K2	5.24674793827802
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	25/1273	73/9376	2.52235577699104	CXCR4/KAT2B/APOBEC3G/NUP153/RANBP2/SUPT5H/MX1/CCNT2/MDFIC/CREBBP/ELL2/MX2/XPO1/AFF4/ELL/EP300/TNPO3/CPSF6/APOBEC3H/APOBEC3C/PSIP1/CCNT1/CHMP4A/VPS4B/RAN	5.17538901608365
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	31/1273	101/9376	2.26063014785375	FOXO1/TGFB1/DIAPH1/BCL2/PIK3R1/STAT1/SMAD3/MAPK1/STAT5B/AKT3/NFKB1/KRAS/NFATC1/PIK3CB/TNF/CDKN1B/SERPINE1/STAT3/PRKCB/PLCG2/PRKCE/STAT5A/PIM1/RELA/PIK3CA/SMAD2/MAPK8/BAX/CASP3/AKT2/MAPK14	5.04856947782831
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	26/1273	78/9376	2.45509295627128	BTG1/CNOT6L/BTG3/DHX36/HSPD1/DDX6/CNOT1/TENT4A/TENT4B/XRN1/PFKP/HSPA9/PABPC1/ENO1/CNOT6/DCP1A/DIS3/CNOT2/TOB2/CNOT8/ENO2/CNOT4/ZCCHC7/DCP2/PATL1/CNOT9	5.11470028174031
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	34/1273	117/9376	2.14033744905701	BAZ1A/GATAD2A/SMARCA2/GATAD2B/SMARCA5/ARID2/INO80D/BRD9/RSF1/CHD3/BICRAL/SMARCC1/EPC1/TRRAP/ARID1A/EPC2/MBD2/CHD4/INO80/ARID1B/EP400/BRD7/BAZ1B/MORF4L2/SS18/BPTF/BAZ2A/YY1/SMARCA4/RBBP4/BCL7B/ACTR6/ING3/RBBP7	4.9195026214461
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	47/1273	187/9376	1.85116634670722	CCL5/TNFAIP3/CASP8/BCL2/TRAF3/JAK1/STAT1/GBP5/ITPR1/BIRC3/GBP2/MAPK1/GABARAPL1/BIRC2/NEK7/NFKB1/HSP90AA1/RIPK1/TNF/ATG16L1/HSP90AB1/MAP1LC3B/GBP4/GBP1/TAB2/TRPM7/TANK/TXN/RELA/TP53BP1/VDAC1/NLRP1/IRF9/ATG5/MCU/TRAF5/ATG12/MAPK8/IRF3/NFKBIA/RHOA/DNM1L/PSTPIP1/ITPR3/CASP4/MAPK14/TICAM1	4.65991550815024
Organismal Systems	Immune system	hsa04611	Platelet activation	35/1273	126/9376	2.04591079689273	FYN/RASGRP1/PIK3R1/ITPR1/MAPK1/AKT3/RAP1A/PPP1R12A/RAP1B/APBB1IP/PIK3CB/STIM1/ITGB1/ARHGAP35/PLCG2/ORAI1/TLN1/GNAS/F2R/ARHGEF1/PIK3R5/ROCK1/PPP1CC/PIK3CA/GNAI3/LCP2/RHOA/VWF/PRKCI/MYL12B/GNA13/ITPR3/MYL12A/AKT2/MAPK14	4.68474517942004
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	34/1273	122/9376	2.05261870114484	FOXO1/PIK3R1/KAT2B/STAT1/MED13/MAPK1/AKT3/NCOR1/KRAS/MAP2K1/SIN3A/PIK3CB/GSK3B/CREBBP/PFKP/NCOA3/ATP2A3/PRKCB/PLCG2/RAF1/EP300/MED14/ATP1A1/SLC9A1/ATP2A2/ATP1B3/PIK3CA/NCOA2/NOTCH1/RHEB/MED27/MDM2/AKT2/MAP2K2	4.63834629838075
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	34/1273	122/9376	2.05261870114484	PIK3R1/STAT1/ITPR1/MAPK1/STAT5B/AKT3/SOCS1/SOS1/KRAS/MAP2K1/PIK3CB/GSK3B/CREBBP/STAT3/MAP2K3/PRKCB/PLCG2/RAF1/STAT5A/GNAS/EP300/PIK3CA/GNAI3/MAPK8/MAP2K4/CRK/CREB1/GRB2/SOS2/ATF4/ITPR3/AKT2/MAPK14/MAP2K2	4.63834629838075
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	38/1273	144/9376	1.94361525704809	RORA/ATXN1/PIK3R1/ITPR1/MAP3K5/AKT3/ERN1/PIK3CB/ATXN2L/ATP2A3/PRKCB/PSMA6/PSMD12/CYCS/VDAC1/PSMD7/RB1CC1/PSMA5/ATP2A2/PSMA7/MCU/PIK3CA/PIK3C3/MAPK8/GTF2B/OPA1/NOP56/PUM1/ATG2A/ATG101/PSMD14/PUM2/ATG13/ITPR3/AKT2/ATG2B/BECN1/TBPL1	4.52277750003911
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	55/1273	238/9376	1.70206024279311	RASGRP1/PIK3R1/CALM1/GNB1/RALGAPA1/GNG2/ETS1/REL/STK4/MAPK1/RASA2/AKT3/RAP1A/RAC2/SOS1/RAP1B/NFKB1/RASAL3/KRAS/MAP2K1/RASSF5/PIK3CB/LAT/FLT3LG/RALGDS/RALA/PRKCB/PLCG2/RAF1/RRAS2/RASGRF2/RELA/PAK2/RAB5A/RASA3/RALGAPB/KSR1/GNB5/PTPN11/EXOC2/ZAP70/PIK3CA/RASA1/MAPK8/PAK1/GRB2/SOS2/RHOA/ANGPT2/SHOC2/ARF6/AKT2/TIAM1/NF1/MAP2K2	4.34824696162636
Human Diseases	Cancer: specific types	hsa05214	Glioma	24/1273	76/9376	2.32587753752016	CAMK1D/PIK3R1/CALM1/BRAF/MAPK1/AKT3/CDKN1A/SOS1/KRAS/MAP2K1/PIK3CB/PRKCB/PLCG2/RAF1/PIK3CA/DDB2/MDM2/GRB2/BAX/SOS2/CDK6/CAMK4/AKT2/MAP2K2	4.59987103267717
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	31/1273	110/9376	2.07566949939299	BCL2/PIK3R1/IFNG/PFKFB3/MAPK1/AKT3/CDKN1A/LDHA/NFKB1/MAP2K1/PIK3CB/CREBBP/PFKP/CDKN1B/SERPINE1/STAT3/PRKCB/PLCG2/GAPDH/RELA/EP300/ENO1/PGK1/PIK3CA/RPS6KB1/HK1/ENO2/ANGPT2/AKT2/IFNGR1/MAP2K2	4.49786037389178
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	30/1273	106/9376	2.08451288740014	FOXO1/BCL2/PIK3R1/BRAF/MAPK1/AKT3/CDKN1A/SOS1/ZEB1/NFKB1/KRAS/HSP90AA1/MAP2K1/PIK3CB/GSK3B/CREBBP/CDKN1B/HSP90AB1/RAF1/RELA/EP300/PIK3CA/CREB1/MDM2/NFKBIA/GRB2/SOS2/ATF4/AKT2/MAP2K2	4.45066291934398
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	36/1273	138/9376	1.9213770962123	FOXO1/CBLB/PIK3R1/CALM1/BRAF/RAPGEF1/MAPK1/AKT3/SOCS1/SOS1/PRKAG2/KRAS/PRKAR2A/MAP2K1/PIK3CB/GSK3B/RAF1/SORBS1/PTPN1/INPP5A/PRKAA1/PPP1CC/SOCS4/PIK3CA/MAPK8/CRK/RPS6KB1/RHEB/CBL/HK1/GRB2/SOS2/PRKCI/AKT2/FLOT2/MAP2K2	4.32180230795343
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	44/1273	181/9376	1.79045453164535	TGFB1/CASP8/BCL2/CALM1/IFNG/JAK1/STAT1/HLA-DPB1/MAPK1/AKT3/LSP1/HSPD1/NFKB1/PLK3/CREBBP/TNF/HLA-DRB5/HSPA9/PPP3CC/CORO1A/RAF1/IL10RA/MALT1/CYCS/HLA-DPA1/RELA/RAB5A/EP300/KSR1/PIK3C3/PPP3CB/HLA-DRB1/MAPK8/PPP3CA/CREB1/BAX/ITGB2/CASP3/RHOA/TRADD/AKT2/IFNGR1/MAPK14/HLA-DQA2	4.25615303182741
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	14/1273	34/9376	3.03276188715863	RORA/BHLHE40/CRY1/PER1/CSNK1D/PRKAG2/CUL1/NR1D2/PRKAA1/CREB1/PER2/FBXL3/FBXW11/RORB	4.70633629736125
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	20/1273	60/9376	2.45509295627128	PIK3R1/SH2D2A/MAPK1/AKT3/NFATC2/RAC2/MAPKAPK2/KRAS/MAP2K1/PIK3CB/PPP3CC/PRKCB/PLCG2/RAF1/PIK3CA/PPP3CB/PPP3CA/AKT2/MAPK14/MAP2K2	4.48155307613364
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	22/1273	70/9376	2.31480193019863	FYN/HLA-B/HLA-A/HLA-C/CASP8/HLA-DPB1/ITGAL/HLA-F/HLA-E/RAC2/SNTB1/HLA-DRB5/CYCS/HLA-DPA1/CD40LG/PRF1/HLA-DRB1/EIF4G2/ITGB2/CASP3/SNTB2/HLA-DQA2	4.37627645829702
Human Diseases	Immune disease	hsa05330	Allograft rejection	15/1273	39/9376	2.83279956492839	HLA-B/HLA-A/HLA-C/IFNG/HLA-DPB1/HLA-F/HLA-E/TNF/HLA-DRB5/FAS/HLA-DPA1/CD40LG/PRF1/HLA-DRB1/HLA-DQA2	4.54590669720073
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	24/1273	80/9376	2.20958366064415	BCL2/PIK3R1/JAK1/BRAF/MAPK1/AKT3/SOS1/KRAS/MAP2K1/PIK3CB/GSK3B/STAT3/PRKCB/PLCG2/RAF1/BCL2L11/PIK3CA/RPS6KB1/GRB2/BAX/SOS2/AKT2/NF1/MAP2K2	4.30635440098051
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	39/1273	158/9376	1.81801187268189	PPP2R5C/TGFB1/CCNH/YWHAZ/SMAD3/CDKN1A/YWHAQ/STAG2/PPP2R5A/PPP2CA/RBL2/GSK3B/NIPBL/CREBBP/BUB3/CDKN1B/CUL1/CCND3/RAD21/DBF4/STAG1/PDS5A/EP300/CCND2/PPP2R5E/PTTG1/ANAPC16/WAPL/SMC1B/SMAD2/MCM6/YWHAB/MDM2/PRKDC/CDKN2D/CDK6/PDS5B/YWHAG/CDC14A	4.11004634720685
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	31/1273	116/9376	1.96830728390714	CXCR4/EZR/ITK/PIK3R1/ACTN4/ITGAL/RHOH/MSN/CD99/RAP1A/PTK2B/RAC2/RAP1B/RASSF5/PIK3CB/MYL9/ITGB1/ARHGAP35/PRKCB/PLCG2/PTPN11/ROCK1/PIK3CA/GNAI3/ITGA4/ITGB2/RHOA/VAV1/MYL12B/MYL12A/MAPK14	4.15923654741096
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	21/1273	67/9376	2.30852024246403	CALM1/RPS6KA3/BRAF/ITPR1/MAPK1/RAP1A/RAP1B/KRAS/MAP2K1/CREBBP/PPP3CC/PRKCB/RAF1/EP300/PPP1CC/PPP3CB/PPP3CA/ATF4/CAMK4/ITPR3/MAP2K2	4.26033011664722
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/1273	32/9376	2.99214454045562	GABARAPL1/PPP2CA/ATG16L1/ATG4B/ATG5/PIK3C3/ATG12/ATG2A/ATG101/IGBP1/ATG13/ATG2B/BECN1	4.47410673420399
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	22/1273	72/9376	2.250501876582	CASP8/TRAF3/CYLD/RNF125/NFKB1/RIPK1/TNF/ADAR/TANK/RELA/OTUD5/ZNFX1/ATG5/DDX3X/ATG12/MAPK8/ISG15/IRF3/NFKBIA/TRADD/IFIH1/MAPK14	4.22175149384988
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	27/1273	98/9376	2.02920948426503	PIK3R1/CALM1/ITPKB/INPP4B/PIP4K2A/ITPR1/INPP4A/PIK3CB/PIP5K1A/SYNJ2/PRKCB/PLCG2/PI4KA/CDS2/INPP5A/INPP5D/SACM1L/PIK3CA/PIK3C3/DGKZ/DGKD/IP6K1/PI4K2B/SYNJ1/ITPR3/MTMR6/IMPA1	4.05944399305392
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	27/1273	98/9376	2.02920948426503	PTPRC/PIK3R1/MAPK1/AKT3/RAC2/MAP2K1/PIK3CB/LAT/PIP5K1A/ARPC5L/PRKCB/PLCG2/RAF1/PRKCE/DNM2/ARPC2/INPP5D/PIK3CA/CRK/RPS6KB1/PAK1/ACTR3/VAV1/ARF6/AKT2/LIMK2/CFL1	4.05944399305392
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	29/1273	109/9376	1.95956960729909	FOXO1/PIK3R1/PRKCQ/RPS6KA3/OGA/AKT3/PRKAG2/NFKB1/PIK3CB/GSK3B/SLC27A4/TNF/STAT3/OGT/PRKCB/GFPT1/PRKCE/RELA/PTPN1/PTPN11/PRKAA1/PPP1CC/PIK3CA/MAPK8/RPS6KB1/CREB1/CPT1A/NFKBIA/AKT2	3.99389894515776
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	27/1273	99/9376	2.00871241876741	BCL2/PIK3R1/BRAF/MAPK1/AKT3/CDKN1A/SOS1/NCOR1/KRAS/MAP2K1/ESR2/PIK3CB/NCOA3/CDKN1B/RAF1/GNAS/PIK3CA/NOTCH1/MAPK8/RPS6KB1/MDM2/GRB2/BAX/SOS2/AKT2/MAPK14/MAP2K2	3.99906172305178
Genetic Information Processing	Transcription	hsa03040	Spliceosome	53/1273	243/9376	1.60641884793059	SRSF7/HNRNPC/HSPA8/PRPF38B/FUS/RBM25/SRSF2/DDX5/SF3B1/WBP11/SRSF4/SNW1/ACIN1/HNRNPU/SF1/CWC25/CASC3/SNRNP200/SF3B2/SNRPA1/SRSF10/SLU7/PRPF8/SNIP1/RBMX/BUD31/HSPA1B/CCDC12/ISY1/TXNL4A/PRPF40A/BCAS2/HNRNPM/SRSF3/HSPA6/TRA2B/SF3B3/DDX39B/HNRNPA3/EIF4A3/CDC40/RBM8A/DHX8/SNRPB/SF3A1/U2SURP/RBM22/DHX38/PRPF6/SNRPD2/CDC5L/SMNDC1/TRA2A	3.7961732062722
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	14/1273	38/9376	2.71352379377351	PTPRC/IL2RG/CD3E/CD3D/CD8A/LCK/TAP1/ORAI1/CD40LG/ZAP70/CD8B/TAP2/ICOS/JAK3	4.19499959706191
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	15/1273	44/9376	2.51089052345926	HLA-B/HLA-A/HLA-C/IFNG/HLA-DPB1/HLA-F/HLA-E/HSPD1/TNF/HLA-DRB5/FAS/HLA-DPA1/PRF1/HLA-DRB1/HLA-DQA2	3.98151990264571
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	39/1273	168/9376	1.70979688026035	STAT4/TNFAIP3/CASP8/BCL2/IFNG/JAK1/STAT1/CYLD/BIRC3/STAT5B/BIRC2/HSP90AA1/CFLAR/CAPN2/RIPK1/GLUD1/TNF/STAT3/HSP90AB1/TRPM7/FAS/STAT5A/VDAC1/ZBP1/IRF9/TRAF5/SQSTM1/HMGB1/MAPK8/JAK3/BAX/TNFRSF10A/CHMP4A/VPS4B/DNM1L/TRADD/EIF2AK2/IFNGR1/TICAM1	3.67945073391074
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	18/1273	59/9376	2.24703423116354	PIK3R1/BRAF/MAPK1/AKT3/CDKN1A/SOS1/KRAS/MAP2K1/PIK3CB/GSK3B/RAF1/PIK3CA/DDB2/GRB2/BAX/SOS2/AKT2/MAP2K2	3.80840611400954
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	15/1273	45/9376	2.45509295627128	HLA-B/HLA-A/HLA-C/IFNG/HLA-DPB1/HLA-F/HLA-E/TNF/HLA-DRB5/FAS/HLA-DPA1/PRF1/HLA-DRB1/KLRD1/HLA-DQA2	3.87801800547845
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	12/1273	32/9376	2.76197957580518	CASP8/BCL2/BIRC3/BIRC2/BCL2L11/CYCS/BIRC6/PMAIP1/MAPK8/BAX/CASP3/BECN1	3.95718509653768
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	27/1273	105/9376	1.8939288519807	UBC/ARIH1/GABARAPL1/OPTN/KRAS/HUWE1/USP15/MAP1LC3B/SMURF1/RRAS2/EIF2AK3/SMURF2/TBC1D15/USP8/RELA/RAB5A/SQSTM1/VCP/MAPK8/OPA1/CALCOCO2/TAX1BP1/ATF4/BCL2L13/RABGEF1/BECN1/RHOT2	3.65099496593026
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	35/1273	149/9376	1.73009906314419	FYN/PIK3R1/MAPK1/AKT3/CYTH1/PTK2B/SOS1/AGPAT3/KRAS/MAP2K1/PIK3CB/RALGDS/RALA/PIP5K1A/PLCG2/RAF1/RRAS2/DNM2/GNAS/F2R/PTPN11/PIK3R5/PIK3CA/DGKZ/RHEB/DGKD/AGPAT4/GRB2/SOS2/RHOA/ARF6/GNA13/CYTH3/AKT2/MAP2K2	3.56058686694056
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	24/1273	90/9376	1.96407436501702	FOXO1/PIK3R1/AKT3/PRKAG2/NFKB1/KRAS/PIK3CB/EHMT1/ADIPOR2/RELA/RB1CC1/ATG5/PRKAA1/PIK3CA/SIRT1/RPS6KB1/RHEB/CREB1/ATG101/BAX/ATF4/ATG13/CAMK4/AKT2	3.64245647254013
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	46/1273	212/9376	1.59812654700677	SKAP1/PIK3R1/CALM1/ITGAL/BRAF/EVL/RAPGEF1/SIPA1L1/MAPK1/AKT3/RAP1A/RAC2/RAP1B/KRAS/MAP2K1/APBB1IP/RASSF5/PIK3CB/LAT/ITGB1/RALGDS/MAP2K3/RALA/PRKCB/RAF1/FYB1/TLN1/GNAS/F2R/PRKD2/RAPGEF2/PIK3CA/GNAI3/CRK/LCP2/ITGB2/RHOA/ANGPT2/PRKCI/VAV1/RAPGEF6/AKT2/TIAM1/MAPK14/GNAO1/MAP2K2	3.49136608734935
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	33/1273	139/9376	1.74859138612127	BCL2/PIK3R1/CALM1/ITPR1/MAPK1/HSPA8/AKT3/FKBP5/SOS1/KRAS/HSP90AA1/MAP2K1/ESR2/PIK3CB/NCOA3/HSP90AB1/RAF1/GNAS/HSPA1B/RARA/PIK3CA/GNAI3/NCOA2/CREB1/HSPA6/GRB2/SOS2/ATF4/GABBR1/ITPR3/AKT2/GNAO1/MAP2K2	3.52422537910829
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	38/1273	168/9376	1.66595593461265	STAT4/IL2RG/BCL2/PIK3R1/IFNG/MCL1/JAK1/STAT1/STAT5B/AKT3/CDKN1A/SOCS1/SOS1/PIK3CB/CREBBP/IL4R/STAT3/IL21R/CCND3/IL2RB/RAF1/IL10RA/STAT5A/PIM1/EP300/CCND2/PTPN2/PTPN11/PIAS1/IRF9/SOCS4/PIK3CA/JAK3/IL27RA/GRB2/SOS2/AKT2/IFNGR1	3.45218768989791
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	33/1273	140/9376	1.73610144764897	CALM1/GNB1/GNG2/ITPR1/SMAD3/MAPK1/AKT3/PRKAG2/KRAS/HDAC4/MAP2K1/SERPINE1/NRF1/MAP1LC3B/MEF2D/ACTA2/RAF1/PRKCE/RRAS2/GNB5/PRKAA1/SLC9A1/PIK3R5/GNAI3/PIK3C3/SMAD2/RPS6KB1/GNA13/CAMK4/ITPR3/AKT2/BECN1/MAP2K2	3.47805662345131
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	20/1273	71/9376	2.07472644191939	SLC7A5/PIK3R1/GLS/MAPK1/AKT3/LDHA/KRAS/MAP2K1/PIK3CB/PFKP/SLC16A3/RAF1/IDH2/PKM/PIK3CA/TIGAR/HK1/AKT2/PGAM1/MAP2K2	3.60284717207733
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	38/1273	170/9376	1.64635645302897	EZR/MYH9/TUBA4A/RAB8B/PPP2R2B/ACTN4/PATJ/MSN/MAP3K5/RAP1A/MYH11/PRKAG2/PPP2R2A/HSPA4/MYL9/PPP2CA/ITGB1/ARPC5L/PRKCE/RAP2C/PPP2R2D/RAPGEF2/ARPC2/PRKAA1/ROCK1/MAPK8/TUBA1A/WHAMM/RUNX1/ACTR3/HCLS1/DLG1/RHOA/PRKCI/MYL12B/RAPGEF6/MYL12A/TIAM1	3.37083880617364
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	24/1273	93/9376	1.90071712743583	BCL2/TRAF3/PIK3R1/TRAF1/BIRC3/AKT3/CDKN1A/BIRC2/NFKB1/PIK3CB/CDKN1B/ITGB1/CYCS/MAX/RELA/PIK3CA/TRAF5/DDB2/NFKBIA/BAX/CASP3/CDK6/AKT2/TRAF4	3.45989278178241
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	21/1273	78/9376	1.98295969544988	TGFB1/IFNG/JAK1/STAT1/HLA-DPB1/MAPK1/NFKB1/TNF/HLA-DRB5/ITGB1/PRKCB/TAB2/HLA-DPA1/RELA/HLA-DRB1/NFKBIA/ITGA4/ITGB2/IFNGR1/MAPK14/HLA-DQA2	3.45513612005937
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	24/1273	94/9376	1.8804967324631	TNFAIP3/CASP8/TRAF3/IFNG/MAPK1/JUND/NFKB1/HSP90AA1/GSK3B/TNF/HSP90AB1/TAB2/RELA/FOSL1/TRAF5/USP25/MAPK8/CCL20/NFKBIA/MAPK6/CASP3/TRADD/TRAF4/MAPK14	3.40053942227325
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	43/1273	201/9376	1.57565667342783	FOXO1/REL/TRAF1/BIRC3/BCL11B/FUS/CDKN1A/KDM6A/BIRC2/BCL6/KMT2A/ZEB1/NFKB1/NCOR1/EWSR1/SIN3A/CCNT2/DDX5/CDKN1B/IL2RB/ETV6/ATF1/MAX/RELA/SUPT3H/DDIT3/CCND2/ID2/ELK4/RUNX2/FUT8/RARA/SS18/RUNX1/CCNT1/PER2/DDB2/MDM2/ITGB7/BAX/TAF15/NR4A3/FLI1	3.26990741797545
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	14/1273	44/9376	2.34349782189531	CCNH/GTF2A1/TAF7/TAF3/TAF1/TAF5L/GTF2B/MNAT1/TAF11/TAF2/TAF15/TAF13/GTF2F1/TBPL1	3.54040430724931
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	47/1273	226/9376	1.53171728687721	ATP2B4/PIK3R1/CALM1/BRAF/MAPK1/AKT3/RAP1A/PDE4B/PPP1R12A/RAC2/RAP1B/NFKB1/MAP2K1/NFATC1/PDE4A/PIK3CB/MYL9/CREBBP/ATP2A3/ORAI1/RAF1/RRAS2/GNAS/F2R/RELA/EP300/ATP1A1/ABCC4/SLC9A1/ROCK1/ATP2A2/ATP1B3/PPP1CC/PIK3CA/GNAI3/MAPK8/CREB1/PAK1/PTGER2/NFKBIA/RHOA/VAV1/GABBR1/CAMK4/AKT2/TIAM1/MAP2K2	3.20701782045638
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	70/1273	368/9376	1.4010041326548	BCL2/TUBA4A/SRSF7/MAP3K5/NUP153/NUP98/RANBP2/OPTN/FUS/KLC1/TNFRSF1B/ERN1/SETX/TUBB4B/TNF/ATXN2L/MAP2K3/MAP1LC3B/PPP3CC/PSMA6/UBQLN1/SOD1/PSMD12/SDHA/EIF2AK3/TANK/CYCS/RAB5A/HSPA5/VDAC1/DDIT3/PSMD7/NUP88/RB1CC1/PSMA5/PSMA7/MCU/NXT1/PIK3C3/PPP3CB/SQSTM1/VCP/PPP3CA/TUBA1A/NDUFA10/TPR/NUP58/KIF5B/SRSF3/DERL1/ATG2A/ATG101/PSMD14/BAX/HNRNPA3/CASP3/POM121/NDUFS5/ATF4/ATG13/ITPR3/POM121C/VAPB/NUP54/NXF1/ATG2B/BECN1/NDUFA6/MAPK14/SEC13	3.11053784423141
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	69/1273	362/9376	1.40387912140374	PPP2R5C/IL2RG/BCL2/PIK3R1/MCL1/JAK1/GNB1/PPP2R2B/GNG2/YWHAZ/DDIT4/MAPK1/AKT3/NR4A1/CDKN1A/SOS1/YWHAQ/NFKB1/ITGA5/KRAS/HSP90AA1/MAP2K1/PPP2R2A/PPP2R5A/PIK3CB/PPP2CA/RBL2/GSK3B/CDC37/IL4R/CDKN1B/ITGB1/FLT3LG/HSP90AB1/CCND3/IL2RB/ITGA1/TNC/RAF1/BCL2L11/F2R/RELA/PPP2R2D/CCND2/GNB5/PPP2R5E/PRKAA1/PIK3R5/PIK3CA/RPS6KB1/YWHAB/RHEB/CREB1/MDM2/JAK3/ITGB7/GRB2/PPP2R3C/ITGA4/SOS2/VWF/ANGPT2/CDK6/ATF4/AKT2/YWHAG/EIF4B/PHLPP2/MAP2K2	3.10616006497306
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	20/1273	75/9376	1.96407436501702	CASP8/BCL2/PIK3R1/BIRC3/MAP3K5/MAPK1/AKT3/CDKN1A/BIRC2/PIK3CB/REV3L/FAS/CYCS/PIK3CA/PMAIP1/MDM2/BAX/CASP3/TOP2B/AKT2	3.32241030466254
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	30/1273	130/9376	1.69967973895704	TGFB1/PIK3R1/GNB1/GNG2/MAPK1/AKT3/SOS1/NFKB1/KRAS/MAP2K1/PIK3CB/ACTA2/RAF1/GNAS/RELA/GNB5/PIK3CA/GNAI3/SMAD2/MAPK8/MAP2K4/CREB1/NFKBIA/GRB2/SOS2/ATF4/AKT2/MAPK14/GNAO1/MAP2K2	3.18398453863716
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	26/1273	109/9376	1.75685550999229	CCL5/CASP8/TRAF3/PIK3R1/JAK1/STAT1/MAPK1/AKT3/NFKB1/MAP2K1/PIK3CB/RIPK1/TNF/MAP2K3/TAB2/RELA/IRF9/PIK3CA/MAPK8/MAP2K4/IRF3/NFKBIA/AKT2/MAPK14/TICAM1/MAP2K2	3.15016690816558
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	27/1273	115/9376	1.72923938659107	BCL2/AKAP13/BRAF/ITPR1/STK39/MAPK1/GATA3/WNK1/JUND/PDE4B/NR4A2/CDKN1A/MAP2K1/PDE4A/PRKCB/MEF2D/RAF1/GNAS/ARHGEF1/RUNX2/GNAI3/CREB1/OXSR1/RHOA/ATF4/GNA13/ITPR3	3.11865271628174
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	24/1273	99/9376	1.78552215001547	PIK3R1/MAPK1/AKT3/RAC2/SOS1/KRAS/MAP2K1/PIK3CB/RALGDS/PIP5K1A/PRKCB/RAF1/GPCPD1/PCYT1A/PIK3CA/DGKZ/MAPK8/RPS6KB1/RHEB/DGKD/GRB2/SOS2/AKT2/MAP2K2	3.11421918109701
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	32/1273	144/9376	1.63672863751418	FOXO1/CASP8/TRAF3/MAP3K5/AKT3/PRKAG2/NFKB1/LPIN1/RIPK1/GSK3B/TNF/MAP2K3/LPIN2/TAB2/ADIPOR2/FAS/RELA/PRKAA1/MAPK8/SIRT1/MAP2K4/CPT1A/IRF3/TRA2B/NFKBIA/CASP3/TRADD/AKT2/MAP3K14/MAPK14/TRA2A/TICAM1	3.05186031475214
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	17/1273	62/9376	2.01951194790056	FOXO1/PIK3R1/HSPA8/AKT3/PRKAG2/KRAS/PIK3CB/SOD1/HSPA1B/ATG5/PRKAA1/PIK3CA/CRYAB/SIRT1/RPS6KB1/HSPA6/AKT2	3.19225053384919
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	30/1273	133/9376	1.66134109822868	PPP2R5C/CALM1/GNB1/PPP2R2B/GNG2/ITPR1/AKT3/PPP2R2A/PPP2R5A/PPP2CA/GSK3B/PPP3CC/PRKCB/GNAS/PPP2R2D/GNB5/PPP2R5E/PPP1CC/GNAI3/PPP3CB/MAPK8/PPP3CA/CREB1/KIF5B/PPP2R3C/ATF4/ITPR3/AKT2/MAPK14/GNAO1	3.04454064823873
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	20/1273	78/9376	1.8885330432856	ITPKB/INPP4B/PIP4K2A/INPP4A/PIK3CB/PIP5K1A/SYNJ2/PLCG2/PI4KA/INPP5A/INPP5D/SACM1L/PIK3CA/PIK3C3/TPI1/IP6K1/PI4K2B/SYNJ1/MTMR6/IMPA1	3.12322328772318
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	28/1273	122/9376	1.69039187153104	FOXO1/PPP2R5C/PIK3R1/PPP2R2B/PFKFB3/AKT3/PRKAG2/PPP2R2A/PPP2R5A/PIK3CB/PPP2CA/PFKP/CAB39/ADIPOR2/PPP2R2D/PPP2R5E/PRKAA1/TBC1D1/PIK3CA/SIRT1/RPS6KB1/RHEB/CREB1/CPT1A/STRADA/RAB10/PPP2R3C/AKT2	3.04219997066872
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	34/1273	158/9376	1.58493342746627	SLC7A5/PIK3R1/RPS6KA3/BRAF/DDIT4/MAPK1/AKT3/SOS1/LPIN1/KRAS/MAP2K1/PIK3CB/GSK3B/TNF/LPIN2/CAB39/PRKCB/RAF1/CLIP1/SLC3A2/PRKAA1/FNIP1/PIK3CA/RPS6KB1/RHEB/STRADA/GRB2/SOS2/RHOA/MAPKAP1/AKT2/EIF4B/MAP2K2/SEC13	2.93895917309236
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	25/1273	107/9376	1.72085954878828	FOXO1/CALM1/ITPR1/AKT3/PPP4R3A/LDHA/PRKAG2/CREBBP/PFKP/PPP3CC/GNAS/PKM/EP300/PPP4R3B/PRKAA1/PPP3CB/SIRT1/PPP3CA/CREB1/CPT1A/SIK2/ATF4/ITPR3/AKT2/PGAM1	2.97237105852169
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	18/1273	70/9376	1.8939288519807	PRKCQ/AKT3/TNFRSF1B/PRKAG2/NFKB1/TNF/STAT3/ADIPOR2/RELA/ACSL5/PTPN11/ACSL4/PRKAA1/MAPK8/CPT1A/NFKBIA/TRADD/AKT2	2.9754137870216
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	22/1273	93/9376	1.74232403348284	FYN/ACTN4/SMAD3/MAPK1/RAP1A/RAC2/RAP1B/MYL9/CREBBP/SMURF1/IQGAP1/SMURF2/SORBS1/PTPRJ/EP300/PTPN1/ROCK1/YES1/PDCD10/RHOA/MYL12B/MYL12A	2.85146300315453
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	25/1273	110/9376	1.67392701563951	TGFB1/SKI/SKIL/IFNG/SMAD7/SMAD3/MAPK1/EMP3/NCOR1/SIN3A/PPP2CA/CREBBP/TNF/CUL1/SMURF1/TGIF2/SMURF2/EP300/ID2/ROCK1/LEMD3/SMAD2/RPS6KB1/RHOA/TGIF1	2.81799346383869
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	33/1273	157/9376	1.5481159405787	TGFB1/DUSP2/DUSP16/ATP11B/MAPK1/NFATC2/ATP8A1/MAPKAPK2/ODC1/MAP2K1/NFATC1/DUSP5/DUSP4/ATP2A3/SLC16A1/PTGER4/GPR132/RAB5A/DUSP8/PTPN11/CD47/ATP2A2/NFATC3/SIRT1/CRK/CREB1/CPT1A/PTGER2/CASP3/ATP11C/XKR6/MAPK14/MAP2K2	2.74509432467406
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	35/1273	170/9376	1.51638094357932	TGFB1/PIK3R1/BRAF/SMAD3/MAPK1/AKT3/SMARCA2/CDKN1A/SOS1/KRAS/MAP2K1/ARID2/NFE2L2/PIK3CB/GSK3B/SMARCC1/PRKCB/PLCG2/RAF1/ARID1A/ARID1B/BRD7/PIK3CA/SMAD2/TXNRD1/RPS6KB1/DDB2/GRB2/BAX/SMARCA4/SOS2/CDK6/CSNK1A1/AKT2/MAP2K2	2.6929984457163
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	19/1273	78/9376	1.79410639112132	SEPTIN6/PIK3R1/ITGA5/PIK3CB/ARHGAP10/ITGB1/ARPC5L/DNM2/CLTB/ARPC2/SEPTIN9/PIK3CA/SEPTIN1/CRK/ACTR3/HCLS1/CBL/RHOA/ELMO2	2.79131045538699
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	11/1273	37/9376	2.18967750153925	BRAF/MAPK1/CDKN1A/KRAS/MAP2K1/TPM3/CCDC6/TPR/DDB2/BAX/MAP2K2	2.87380200506943
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	14/1273	54/9376	1.90951674376655	HLA-B/HLA-A/HLA-C/HLA-DPB1/HLA-F/HLA-E/HLA-DRB5/TG/FAS/HLA-DPA1/CD40LG/PRF1/HLA-DRB1/HLA-DQA2	2.65662313173462
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	21/1273	93/9376	1.66312748650635	CALM1/ITPR1/MAPK1/PTK2B/SOS1/KRAS/MAP2K1/MAP3K2/MAP2K3/PRKCB/RAF1/GNAS/MAP3K3/MAPK8/MAP2K4/GRB2/SOS2/ATF4/ITPR3/MAPK14/MAP2K2	2.54724811384059
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	33/1273	166/9376	1.46418194380034	ATP2B4/CALM1/ITPR1/MAPK1/AKT3/NFATC2/PPP1R12A/MAP2K1/NFATC1/MYL9/PPP3CC/ATP2A3/MEF2D/RAF1/PRKCE/VDAC1/ATP1A1/PIK3R5/ROCK1/ATP2A2/ATP1B3/PPP1CC/GNAI3/PPP3CB/NFATC3/PPP3CA/CREB1/RHOA/ATF4/GNA13/ITPR3/AKT2/MAP2K2	2.39160466754927
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	31/1273	154/9376	1.48262107099499	PPP2R5C/ATP2B4/BCL2/CALM1/CREM/PPP2R2B/MAPK1/AKT3/PPP2R2A/PPP2R5A/PPP2CA/RPS6KA5/TPM2/ATP2A3/TPM4/GNAS/PPP2R2D/TPM3/PPP2R5E/ATP1A1/SLC9A1/PIK3R5/ATP2A2/ATP1B3/PPP1CC/GNAI3/CREB1/PPP2R3C/ATF4/AKT2/MAPK14	2.39348660386527
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	14/1273	56/9376	1.84131971720346	BCL2/CSNK1D/CUL3/GSK3B/CUL1/SMURF1/CSNK1G2/SMURF2/KIF3A/CCND2/GRK2/CSNK1G3/CSNK1A1/FBXW11	2.50278789084136
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	12/1273	46/9376	1.9213770962123	IFNG/PSMB9/PSME4/PSME1/PSME2/PSMA6/PSMD12/PSMD7/PSMB10/PSMA5/PSMA7/PSMD14	2.4828611145023
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	28/1273	138/9376	1.49440440816512	PPP2R5C/CALM1/RPS6KA3/YWHAZ/ITPR1/MAPK1/YWHAQ/MAP2K1/PPP2R5A/PPP2CA/CUL1/PPP3CC/CPEB2/PPP2R5E/PTTG1/ANAPC16/SMC1B/PPP1CC/PPP3CB/PPP3CA/YWHAB/SLK/SPDYA/ITPR3/YWHAG/FBXW11/STAG3/MAPK14	2.31904843419078
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	31/1273	157/9376	1.45429073205878	TGFB1/CASP8/PIK3R1/MAP3K5/AKT3/ERN1/PRKAG2/NFKB1/PIK3CB/GSK3B/TNF/SDHA/EIF2AK3/ADIPOR2/FAS/BCL2L11/CYCS/RELA/ITCH/DDIT3/PRKAA1/PIK3CA/MAPK8/NDUFA10/BAX/CASP3/NDUFS5/ATF4/AKT2/NDUFA6/MAPK14	2.27519547964601
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	35/1273	184/9376	1.4010041326548	FYN/CXCR4/PIK3R1/SEMA4D/MAPK1/NFATC2/RAC2/NCK2/KRAS/PIK3CB/MYL9/GSK3B/ITGB1/PPP3CC/PLCG2/RAF1/PAK2/PTPN11/NCK1/PLXNC1/ROCK1/PIK3CA/GNAI3/PPP3CB/NFATC3/RASA1/PPP3CA/PAK1/SEMA4A/SSH1/RHOA/MYL12B/MYL12A/LIMK2/CFL1	2.17735715395057
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	30/1273	154/9376	1.43479458483386	CAMK1D/CALM1/ITPR1/MAPK1/NFATC2/PPP1R12A/CDKN1A/PRKAG2/KRAS/MAP2K1/NFATC1/MYL9/PPP3CC/PRKCB/RAF1/GNAS/PRKAA1/PIK3R5/ROCK1/PPP1CC/GNAI3/PPP3CB/NFATC3/PPP3CA/RHOA/CAMK4/ITPR3/PPP1R12C/GNAO1/MAP2K2	2.1562983399948
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	15/1273	65/9376	1.69967973895704	PIK3R1/ITPR1/MAPK1/AKT3/KRAS/MAP2K1/ESR2/PIK3CB/PRKCB/RAF1/PIK3CA/GABBR1/ITPR3/AKT2/MAP2K2	2.24354473500731
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	21/1273	100/9376	1.5467085624509	CD44/CD2/CD3E/HLA-DPB1/CD3D/CD3G/CD8A/ITGA5/CD5/TNF/HLA-DRB5/IL4R/FLT3LG/ITGA1/HLA-DPA1/CD37/CD8B/HLA-DRB1/ITGA4/CD7/HLA-DQA2	2.17847422753832
Organismal Systems	Nervous system	hsa04730	Long-term depression	14/1273	60/9376	1.71856506938989	BRAF/ITPR1/MAPK1/KRAS/MAP2K1/PPP2CA/PRKCB/RAF1/GNAS/GNAI3/GNA13/ITPR3/GNAO1/MAP2K2	2.21311462147308
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	66/1273	388/9376	1.25285671479823	CASP8/TUBA4A/PIK3R1/CALM1/BRAF/ITPR1/MAP3K5/MAPK1/AKT3/KLC1/ERN1/NFKB1/KRAS/MAP2K1/PIK3CB/CAPN2/TUBB4B/GSK3B/TNF/PPP3CC/ATP2A3/SLC39A10/RAF1/PSMA6/SLC39A8/PSMD12/SDHA/EIF2AK3/FAS/CYCS/GAPDH/RELA/VDAC1/DDIT3/PSMD7/RB1CC1/PSEN1/PSMA5/ATP2A2/PSMA7/MCU/PIK3CA/PIK3C3/PPP3CB/MAPK8/PPP3CA/TUBA1A/NDUFA10/KIF5B/APBB1/ATG2A/ATG101/PSMD14/CASP3/NDUFS5/ATF4/ATG13/ITPR3/CSNK1A1/AKT2/SLC39A9/ATG2B/BECN1/NDUFA6/EIF2AK2/MAP2K2	2.01620989881949
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	11/1273	44/9376	1.84131971720346	PARP4/APTX/POLB/POLG2/HMGB1/RFC1/POLG/TDG/POLE4/MBD4/TDP1	2.21705752106013
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1273	44/9376	1.84131971720346	ARHGDIB/DYNC1H1/VAMP2/GNAS/RAB5A/DYNC1LI1/RAB11A/DYNLL2/ARHGDIA/CREB1/DYNC1LI2	2.21705752106013
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	17/1273	78/9376	1.60525308679276	IRF1/CALM1/MAPK1/NFKB1/ITGA5/TNF/ITGB1/RELA/GNAI3/MAPK8/IRF3/ITGB2/CASP3/RHOA/MAPK14/CFL1/TICAM1	2.12748479071462
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	12/1273	50/9376	1.76766692851532	CXCR4/TGFB1/HLA-DPB1/HLA-DRB5/HLA-DPA1/CD40LG/HLA-DRB1/ICOS/ITGB7/ITGA4/MAP3K14/HLA-DQA2	2.15718329532018
Human Diseases	Cancer: specific types	hsa05218	Melanoma	16/1273	73/9376	1.61430769727426	PIK3R1/BRAF/MAPK1/AKT3/CDKN1A/KRAS/MAP2K1/PIK3CB/RAF1/PIK3CA/DDB2/MDM2/BAX/CDK6/AKT2/MAP2K2	2.0883957331267
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	79/1273	480/9376	1.21220214715894	ATXN1/CASP8/BCL2/TUBA4A/UBC/CALM1/BRAF/ITPR1/MAP3K5/MAPK1/OPTN/FUS/KLC1/TNFRSF1B/ERN1/UBE2G1/NFKB1/KRAS/MAP2K1/CAPN2/TUBB4B/GSK3B/TNF/ATXN2L/MAP2K3/MAP1LC3B/PPP3CC/ATP2A3/PRKCB/HIP1/RAF1/PSMA6/SOD1/PSMD12/SDHA/EIF2AK3/TANK/FAS/CYCS/RELA/RAB5A/HSPA5/VDAC1/DDIT3/PSMD7/RB1CC1/PSEN1/PSMA5/ATP2A2/PSMA7/MCU/PIK3C3/PPP3CB/SQSTM1/VCP/MAPK8/PPP3CA/TUBA1A/NDUFA10/KIF5B/DERL1/UBE2L3/ATG2A/ATG101/PSMD14/PRNP/BAX/CASP3/NDUFS5/ATF4/ATG13/ITPR3/CSNK1A1/VAPB/ATG2B/BECN1/NDUFA6/MAPK14/MAP2K2	1.89168981737123
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	48/1273	275/9376	1.28557594801114	FYN/CCL5/TUBA4A/PIK3R1/ITPR1/MAPK1/HSPA8/RAC2/KLC1/PIK3CB/TUBB4B/GSK3B/TNF/PPP3CC/PSMA6/SOD1/PSMD12/SDHA/EIF2AK3/CYCS/HSPA5/VDAC1/DDIT3/PSMD7/HSPA1B/PSMA5/STIP1/PSMA7/MCU/PIK3CA/PPP3CB/NOTCH1/MAPK8/PPP3CA/TUBA1A/NDUFA10/CREB1/KIF5B/HSPA6/PSMD14/PRNP/BAX/CASP3/NDUFS5/ATF4/ITPR3/NDUFA6/MAPK14	1.9051112318601
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/1273	63/9376	1.63672863751418	KMT2E/PRDM2/NSD3/KMT2C/EZH2/KMT2A/SETD2/EHMT1/ASH1L/PHYKPL/SETD1B/KMT2B/DLST/NSD1	2.00981821054491
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	16/1273	75/9376	1.57125949201362	CASP8/BCL2/CDKN1A/SERPINE1/CCND3/FAS/CYCS/CCND2/PMAIP1/PPM1D/DDB2/MDM2/BAX/TNFRSF10A/CASP3/CDK6	1.96868466974414
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1273	41/9376	1.79640948019849	BRAF/MAPK1/CDKN1A/KRAS/MAP2K1/RPS6KA5/RAF1/DAPK2/MDM2/MAP2K2	2.02557397691228
Cellular Processes	Cell motility	hsa04814	Motor proteins	35/1273	194/9376	1.328787424786	BICDL1/MYH9/TUBA4A/CAPZA1/KIF13B/MYO1D/ACTG2/KIF21A/DYNC1H1/MYO1F/KLC1/MYH11/KIF2A/MYO9B/MYL9/TUBB4B/TPM2/DYNLT1/TPM4/ACTA2/MYO1G/KIF3A/TPM3/DYNC1LI1/DYNLL2/TUBA1A/KIFAP3/STARD9/KIF5B/KIF21B/DYNLT3/DYNC1LI2/KIF20B/MYL12B/MYL12A	1.83410561291161
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	11/1273	47/9376	1.72378867142451	PIK3R1/MAPK1/SOCS1/PIK3CB/TNF/PRKCE/PKM/SOCS4/PIK3CA/MAPK8/HK1	1.97160578762214
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	29/1273	157/9376	1.36046552353886	TGFB1/SMAD7/PPP2R2B/PATJ/YWHAZ/BIRC3/SMAD3/TP53BP2/CSNK1D/BIRC2/YWHAQ/PPP2R2A/PPP2CA/GSK3B/SERPINE1/CCND3/NKD1/PPP2R2D/CCND2/ID2/PPP1CC/SMAD2/YWHAB/DLG1/ITGB2/LATS1/PRKCI/YWHAG/FBXW11	1.80529663461796
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	18/1273	89/9376	1.48960696223201	TUBA4A/ITPR1/MAPK1/CSNK1D/SOS1/KRAS/MAP2K1/MAP3K2/TUBB4B/PRKCB/RAF1/GNAS/GNAI3/TUBA1A/GRB2/SOS2/ITPR3/MAP2K2	1.83942373451854
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1273	21/9376	2.10436539108966	CHST11/XYLT1/CHST12/CSGALNACT2/UST/CHSY1	2.00806358318621
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	38/1273	217/9376	1.28977233647431	BCL2/PIK3R1/RPS6KA3/MAPK1/STAT5B/AKT3/SOS1/BCL6/NFKB1/KRAS/HSP90AA1/MAP2K1/ESR2/PIK3CB/KPNB1/STAT3/HSP90AB1/CCND3/PRKCB/RAF1/PTGES3/KPNA4/KPNA1/KPNA5/STAT5A/GNAS/RELA/PIK3CA/GNAI3/KPNA2/RPS6KB1/CREB1/AHR/GRB2/SOS2/ATF4/AKT2/MAP2K2	1.71174741451474
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	22/1273	115/9376	1.40900987055569	FYN/BCL2/PIK3R1/GNB1/GNG2/ITPR1/MAPK1/AKT3/KRAS/MAP2K1/PIK3CB/PRKCB/GNB5/PIK3R5/PIK3CA/GNAI3/CREB1/ATF4/CAMK4/ITPR3/AKT2/GNAO1	1.7491646326967
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	25/1273	134/9376	1.37411919194288	PRKCH/MYH9/CALM1/PRKCQ/BRAF/ITPR1/MAPK1/ACTG2/PPP1R12A/MYH11/MAP2K1/MYL9/PRKCB/ACTA2/RAF1/PRKCE/GNAS/ARHGEF1/ROCK1/PPP1CC/RHOA/GNA13/ITPR3/PPP1R12C/MAP2K2	1.72884606312703
Organismal Systems	Digestive system	hsa04978	Mineral absorption	13/1273	61/9376	1.56964959499311	ATP2B4/MT1E/MT2A/MT1X/MT1F/SLC30A1/MT1G/MT1M/TRPM7/ATP1A1/ATP1B3/HMOX2/MT1H	1.76912370349963
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	19/1273	98/9376	1.42796222966799	ATP2B4/CAMK1D/CALM1/ITPR1/NR4A1/NR4A2/LDLR/PRKCB/ORAI1/PRKCE/ATF1/GNAS/PRKD2/ATP1A1/ATP1B3/CREB1/ATF4/CAMK4/ITPR3	1.68798357286834
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/1273	99/9376	1.41353836876225	TGFB1/DES/LMNA/SNTB1/PRKAG2/ITGA5/TNF/ITGB1/TPM2/ITGA1/ATP2A3/TPM4/EMD/TPM3/PRKAA1/ATP2A2/ITGB7/ITGA4/SNTB2	1.63948161117239
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	13/1273	63/9376	1.51981944912031	CCNH/POLR2A/CUL4A/XPC/POLR2B/POLR2K/RFC1/ERCC5/MNAT1/DDB2/DDB1/POLE4/POLR2J3	1.64079724624316
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	28/1273	160/9376	1.28892380204242	HLA-B/HLA-A/CD2/PTPRC/HLA-C/CD6/HLA-DPB1/ITGAL/HLA-F/CD99/CD58/CD8A/HLA-E/HLA-DRB5/ITGB1/ICAM3/CD226/HLA-DPA1/CD40LG/SPN/CD8B/HLA-DRB1/TIGIT/ICOS/ITGB7/ITGA4/ITGB2/HLA-DQA2	1.46099590987921
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	39/1273	233/9376	1.23281491795596	SYNE2/DIAPH1/MYH9/DES/FMNL1/CAPZA1/VIM/LMNA/SPTAN1/ACTG2/SUN2/MYH11/SNTB1/ITGA5/CSRP1/MYL9/PLEC/ITGB1/TPM2/SYNE1/ITGA1/TPM4/ANK3/TLN1/EMD/ENO1/TPM3/ATP1A1/FMNL3/LMNB1/ATP1B3/ITGB7/LBR/TMEM43/ITGA4/ENO2/SUN1/SNTB2/ZYX	1.42633430008904
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	20/1273	110/9376	1.3391416125116	PIK3R1/RPS6KA3/BRAF/MAPK1/AKT3/STK10/KRAS/HSP90AA1/MAP2K1/PIK3CB/HSP90AB1/CPEB2/RAF1/ANAPC16/PIK3CA/GNAI3/MAPK8/SPDYA/AKT2/MAPK14	1.41810437212779
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	26/1273	150/9376	1.27664833726106	TGFB1/BCL2/PIK3R1/BRAF/SMAD3/MAPK1/AKT3/CDKN1A/SOS1/KRAS/MAP2K1/PIK3CB/GSK3B/CDKN1B/RAF1/PIK3CA/SMAD2/RPS6KB1/DDB2/GRB2/BAX/SOS2/ABCB1/CSNK1A1/AKT2/MAP2K2	1.35376689383041
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	18/1273	99/9376	1.3391416125116	PRKCH/PIK3R1/CALM1/PRKCQ/ITPR1/PIK3CB/MAP2K3/PRKCB/PLCG2/PRKCE/PTGER4/GNAS/PPP1CC/PIK3CA/MAPK8/PTGER2/ITPR3/MAPK14	1.34453409718746
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	30/1273	178/9376	1.24133913519334	CCDC88C/SMAD3/NFATC2/RAC2/NFATC1/GSK3B/CREBBP/CUL1/CCND3/PPP3CC/PRKCB/CACYBP/SENP2/NKD1/EP300/FOSL1/CHD8/CCND2/TBL1X/TBL1XR1/TLE3/PSEN1/PPP3CB/NFATC3/MAPK8/SIRT1/PPP3CA/RHOA/CSNK1A1/FBXW11	1.28845119094204
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	5/1273	20/9376	1.84131971720346	SC5D/CYP51A1/EBP/SOAT1/LBR	1.49282149225309
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	12/1273	62/9376	1.42553784557687	ATXN1/KAT2B/SPEN/CREBBP/SNW1/ITCH/EP300/TLE3/PSEN1/MAML1/NOTCH1/NCOR2	1.33242520356248
Human Diseases	Immune disease	hsa05310	Asthma	7/1273	32/9376	1.61115475255302	HLA-DPB1/TNF/HLA-DRB5/HLA-DPA1/CD40LG/HLA-DRB1/HLA-DQA2	1.37257690820611
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	8/1273	38/9376	1.55058502501344	PIK3R1/MAPK1/KRAS/PIK3CB/PRKCB/ATP1A1/ATP1B3/PIK3CA	1.34792639966398
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	51/1273	323/9376	1.16293876876008	CD44/EZR/BCL2/PIK3R1/MCL1/GLS/VIM/EZH2/DDIT4/MAPK1/CDKN1A/SOCS1/SOS1/ABCC1/ZEB1/NFKB1/SLC7A1/ITGA5/KRAS/HDAC4/MAP2K1/PIK3CB/PDCD4/RPS6KA5/CREBBP/CDKN1B/STAT3/PRKCB/PLCG2/TNC/RAF1/PRKCE/BCL2L11/PIM1/EP300/CCND2/ROCK1/PIK3CA/NOTCH1/SIRT1/CRK/MDM2/GRB2/DNMT1/CASP3/SOS2/RHOA/ABCB1/CDK6/UBE2I/MAP2K2	1.18115352887372
NA	NA	hsa04518	Integrin signaling	26/1273	154/9376	1.24348864018935	TGFB1/PIK3R1/ACTN4/ITGAL/AKT3/FLNA/RAC2/NCK2/ITGA5/PIK3CB/GSK3B/ITGB1/CCND3/ITGA1/TNC/ICAM3/TLN1/CCND2/PIK3CA/ITGAE/ITGB7/ITGA4/ITGB2/VWF/PARVG/AKT2	1.20754528451291
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	25/1273	148/9376	1.24413494405639	PIK3R1/BRAF/MAPK1/AKT3/CDKN1A/SOS1/KRAS/MAP2K1/ESR2/NFKB2/PIK3CB/GSK3B/NCOA3/RAF1/PIK3CA/NOTCH1/RPS6KB1/DDB2/GRB2/BAX/SOS2/CDK6/CSNK1A1/AKT2/MAP2K2	1.18654422957698
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	26/1273	155/9376	1.23546613283329	HLA-B/HLA-A/HLA-C/TUBA4A/HLA-DPB1/HLA-F/HLA-E/DYNC1H1/ITGA5/TUBB4B/HLA-DRB5/ITGB1/TAP1/CORO1A/HLA-DPA1/RAB5A/DYNC1LI1/PIK3C3/HLA-DRB1/TAP2/TUBA1A/STX12/DYNC1LI2/ITGB2/STX18/HLA-DQA2	1.17160768009033
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	15/1273	83/9376	1.33107449436394	CCL5/CASP8/NFKB1/RIPK1/ADAR/POLR3E/CGAS/RELA/ZBP1/POLR2K/IRF3/NFKBIA/CASP3/POLR3GL/G3BP1	1.20078076552899
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	24/1273	144/9376	1.22754647813564	SKIL/PIK3R1/JAK1/JARID2/SMAD3/MAPK1/AKT3/KAT6A/KRAS/MAP2K1/PIK3CB/GSK3B/PCGF5/STAT3/RAF1/RIF1/ID2/PIK3CA/SMAD2/JAK3/GRB2/AKT2/MAPK14/MAP2K2	1.09063740103616
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/1273	34/9376	1.51638094357932	POLR2A/POLR3E/POLR2B/POLR2K/CRCP/POLR3GL/POLR2J3	1.19554700104594
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	18/1273	105/9376	1.2626192346538	TGFB1/DES/LMNA/SNTB1/ITGA5/TNF/ITGB1/TPM2/ITGA1/ATP2A3/TPM4/EMD/GNAS/TPM3/ATP2A2/ITGB7/ITGA4/SNTB2	1.07259263592734
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	12/1273	67/9376	1.31915442426516	GALM/LDHA/PFKP/GAPDH/PKM/ENO1/PGK1/TPI1/HK1/ENO2/GPI/PGAM1	1.03911514811392
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	17/1273	100/9376	1.25209740769835	CCL5/CXCR4/IL2RG/TNFRSF1B/CXCR3/TNFSF14/TNF/CCL21/XCL2/IL2RB/IL10RA/CCL20/XCL1/IL18R1/TNFRSF10A/IL18RAP/CCL14	1.00453467024197
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1273	23/9376	1.60114758017692	GLS/GLUD1/ATP1A1/SLC4A4/ATP1B3	1.1440538703576
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	9/1273	48/9376	1.38098978790259	PIK3R1/AKT3/PIK3CB/PRKCB/ATP1A1/ATP1B3/PIK3CA/HK1/AKT2	1.04885778369563
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	8/1273	42/9376	1.40291026072644	MAP1LC3B/SLC39A8/SLC3A2/ACSL5/ATG5/ACSL4/LPCAT3/PRNP	1.03723221047856
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	7/1273	36/9376	1.43213755782491	GALNT10/ST3GAL1/B4GALT5/GALNT11/GALNT7/C1GALT1/GALNT2	1.02961946915021
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/1273	142/9376	1.19296770410365	BCL2/PIK3R1/CALM1/IFNG/MAP3K5/AKT3/RAC2/NFKB1/HSP90AA1/NFE2L2/PIK3CB/TNF/HSP90AB1/TXN/RELA/PRKAA1/PIK3CA/SQSTM1/MAPK8/MAP2K4/RHOA/AKT2/MAPK14	0.918355407088389
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	6/1273	30/9376	1.47305577376277	OGDH/IDH2/SDHA/DLST/CS/ACLY	1.02857746958673
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	6/1273	30/9376	1.47305577376277	ABCC1/NFKB1/TNF/RELA/ABCC4/MTR	1.02857746958673
Organismal Systems	Endocrine system	hsa04924	Renin secretion	12/1273	69/9376	1.28091806414153	CALM1/ITPR1/PPP3CC/ORAI1/PTGER4/GNAS/GNAI3/PPP3CB/PPP3CA/CREB1/PTGER2/ITPR3	0.928274191202122
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	41/1273	268/9376	1.12677773739316	TUBA4A/UBC/CALM1/ITPR1/MAP3K5/KLC1/ERN1/UBE2G1/NFE2L2/TUBB4B/SLC39A10/PSMA6/SOD1/SLC39A8/PSMD12/SDHA/EIF2AK3/CYCS/TXN/GNAS/HSPA5/VDAC1/DDIT3/PSMD7/PSMA5/PSMA7/MCU/GNAI3/MAPK8/TUBA1A/NDUFA10/KIF5B/UBE2L3/PSMD14/BAX/CASP3/NDUFS5/ATF4/ITPR3/SLC39A9/NDUFA6	0.834595047459159
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	6/1273	31/9376	1.42553784557687	SRP54/HSPA5/SPCS3/SRPRA/SRP19/SRP72	0.940602882086559
Human Diseases	Substance dependence	hsa05032	Morphine addiction	15/1273	91/9376	1.21405695639788	PDE7A/GNB1/GNG2/GRK5/PDE4B/PDE4A/PRKCB/PDE8A/GNAS/GNB5/GNAI3/GRK2/GRK6/GABBR1/GNAO1	0.813272352874643
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	12/1273	71/9376	1.24483586515163	CCL5/NFKB1/PLCG2/RELA/PTPN11/MAPK8/MAP2K4/PAK1/NFKBIA/CASP3/MAP3K14/MAPK14	0.820772775264825
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	3/1273	13/9376	1.69967973895704	XRCC6/XRCC5/PRKDC	1.00055365553298
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1273	45/9376	1.30938291001135	ABCC1/ABCA5/TAP1/ABCC4/TAP2/ABCG1/ABCB1/ABCA7	0.824546975119604
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	46/1273	308/9376	1.10000918170596	CASP8/TUBA4A/ITPR1/MAP3K5/POLR2A/KLC1/ERN1/RCOR1/SIN3A/TUBB4B/CREBBP/NRF1/HIP1/PSMA6/SOD1/PSMD12/SDHA/POLR2B/CYCS/EP300/VDAC1/CLTB/PSMD7/RB1CC1/AP2B1/PSMA5/PSMA7/PIK3C3/POLR2K/MAPK8/TUBA1A/NDUFA10/CREB1/KIF5B/ATG2A/ATG101/PSMD14/BAX/CASP3/NDUFS5/ATG13/ATG2B/BECN1/NDUFA6/TBPL1/POLR2J3	0.707353321064537
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	24/1273	155/9376	1.1404302764615	BRAF/ITPR1/MAPK1/RAP1A/NR4A1/CDKN1A/KMT2A/RAP1B/MAP2K1/LDLR/GSK3B/CDKN1B/ORAI1/PDE8A/GNAS/USP8/RBBP5/GNAI3/CREB1/AHR/CDK6/ATF4/ITPR3/MAP2K2	0.698738236534363
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	6/1273	33/9376	1.3391416125116	VAMP2/STX5/VTI1A/STX11/STX16/STX18	0.773520444622981
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1273	53/9376	1.25070773244008	ATP2B4/PRKCB/DNM2/GNAS/CLTB/ATP1A1/AP2B1/ATP1B3/RAB11A	0.725445418232654
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	3/1273	14/9376	1.57827404331725	ST3GAL1/FUT8/B3GNT2	0.858203573968885
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	34/1273	227/9376	1.10316952220119	PIK3R1/BRAF/MAP3K5/MAPK1/AKT3/SOS1/NFKB1/KRAS/MAP2K1/NFE2L2/PIK3CB/RAF1/SOD1/SDHA/PTPRJ/RELA/PRKD2/VDAC1/PTPN1/PTPN11/PIK3CA/MAPK8/MAP2K4/NDUFA10/AHR/NFKBIA/GRB2/SOS2/NDUFS5/AKT2/MAP3K14/NDUFA6/MAPK14/MAP2K2	0.623669426512811
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	16/1273	102/9376	1.15533786177472	ATP2B4/ITPR1/RAP1A/RAP1B/SLC12A2/ATP2A3/PRKCB/GNAS/ATP1A1/SLC9A1/ATP2A2/SLC4A4/ATP1B3/RAB11A/RHOA/ITPR3	0.625202611575561
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/1273	75/9376	1.17844461901021	PFKP/IDH2/GAPDH/PKM/ENO1/PGK1/MAT2A/MTR/TPI1/ENO2/CS/PGAM1	0.614959034825744
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	12/1273	75/9376	1.17844461901021	ITPR1/PRKCB/TG/GNAS/HSPA5/ATP1A1/ALB/ATP1B3/CREB1/TTF2/ATF4/ITPR3	0.614959034825744
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1273	69/9376	1.17417489212974	CALM1/PPP3CC/PRKCB/GNAS/PPP1CC/PPP3CB/SIRT1/PPP3CA/CREB1/ATF4/CAMK4	0.575548808559322
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	15/1273	97/9376	1.13896064981657	CALM1/GNB1/GNG2/ITPR1/MAPK1/PER1/RPS6KA5/PRKCB/GNAS/GNB5/GNAI3/CREB1/PER2/ITPR3/GNAO1	0.54526049898142
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	16/1273	104/9376	1.13311982597136	LPIN1/AGPAT3/LPIN2/GPCPD1/SELENOI/CDS2/PCYT1A/SAMD8/LPGAT1/DGKZ/DGKD/GPAT4/LPCAT3/AGPAT4/PTDSS1/PISD	0.541065222264389
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/1273	35/9376	1.2626192346538	PFKFB3/PFKP/TPI1/TIGAR/HK1/GMDS	0.61693695848464
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	8/1273	50/9376	1.17844461901021	TGFB1/IFNG/ITGAL/KLRK1/TNF/KLRB1/CD40LG/ITGB2	0.501438497569617
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	4/1273	23/9376	1.28091806414153	IDI1/HMGCS1/NUS1/MVD	0.534619799084783
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	6/1273	37/9376	1.19436954629413	GFPT1/UAP1/UGP2/HK1/GMDS/GPI	0.469521858774171
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	17/1273	116/9376	1.07939431698134	SLC38A1/GNB1/GNG2/GLS/ITPR1/MAPK1/HOMER1/PPP3CC/PRKCB/GNAS/GNB5/GNAI3/PPP3CB/GRK2/PPP3CA/ITPR3/GNAO1	0.341027843468306
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	8/1273	52/9376	1.13311982597136	LDLR/NPC1/VDAC1/LRPAP1/SOAT1/VAPB/TSPO/APOA2	0.38152254034263
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/1273	18/9376	1.22754647813564	LMBRD1/MTR/ZNF143	0.382993824000153
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	2/1273	12/9376	1.22754647813564	SLAMF1/NPC1	0.312612946000275
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	7/1273	49/9376	1.05218269554483	OGT/GALNT10/GALNT11/GALNT7/C1GALT1/GALNT2/GXYLT1	0.145154492410587
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	12/1273	86/9376	1.02771333053216	DES/LMNA/SNTB1/ITGA5/ITGB1/ITGA1/ATP2A3/EMD/ATP2A2/ITGB7/ITGA4/SNTB2	0.102330951128154
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	14/1273	101/9376	1.02092974419202	CALM1/MAPK1/KRAS/MAP2K1/GSK3B/CREBBP/PRKCB/RAF1/GNAS/EP300/GNAI3/CREB1/GNAO1/MAP2K2	0.0838194040388936
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	16/1273	116/9376	1.01590053362949	OGDH/GLUD1/PFKP/IDH2/SDHA/GAPDH/PKM/ENO1/PGK1/TPI1/HK1/ENO2/DLST/GPI/CS/PGAM1	0.0682986503295447
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	3/1273	20/9376	1.10479183032207	UAP1/UGP2/GMDS	0.185940604170459
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	9/1273	65/9376	1.01980784337422	ITPR1/NR4A1/LDLR/ORAI1/PDE8A/GNAS/CREB1/ATF4/ITPR3	0.0635144627459536
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	14/1273	103/9376	1.00110586566402	TGFB1/PIK3R1/IFNG/ACTN4/NFKB1/PIK3CB/TNF/PRKCB/GNAS/RELA/RAB5A/PIK3CA/ITGB2/CASP3	0.00447288545843605
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	32/1273	238/9376	0.990289595806901	TRAF3/PIK3R1/JAK1/STAT1/RPS26/MAPK1/MX1/NFKB1/PIK3CB/TNF/MX2/STAT3/ADAR/PRKCB/PLCG2/TAB2/CGAS/RPS4Y1/RPL36AL/RELA/IRF9/PIK3CA/MAPK8/ISG15/IRF3/RSL24D1/NFKBIA/VWF/RPL28/IFIH1/EIF2AK2/MAPK14	-0.0601418980240558
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	11/1273	83/9376	0.976121295866893	GSTK1/FAR2/SOD1/IDH2/ACSL5/ACSL4/PEX14/HACL1/FAR1/PHYH/ECI2	-0.0866061539529923
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	10/1273	76/9376	0.969115640633398	EZR/CALM1/ITPR1/PRKCB/GNAS/ATP1A1/SLC9A1/ATP1B3/GNAI3/ITPR3	-0.107147203262024
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1273	38/9376	0.969115640633398	GFPT1/UAP1/UGP2/HK1/GPI	-0.0756101990349921
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	15/1273	115/9376	0.960688548106151	GNB1/GNG2/BRAF/ITPR1/MAPK1/KRAS/MAP2K1/PRKCB/RAF1/GNAS/GNB5/GNAI3/CASP3/ITPR3/GNAO1	-0.168118684322353
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	2/1273	15/9376	0.98203718250851	ST8SIA1/ST3GAL1	-0.0275953486079018
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	4/1273	32/9376	0.920659858601728	GALM/PFKP/UGP2/HK1	-0.178188004792824
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	12/1273	95/9376	0.930351015008062	CCL5/TGFB1/IFNG/HLA-DPB1/ITGAL/TNF/HLA-DRB5/HLA-DPA1/HLA-DRB1/CCL20/ITGB2/HLA-DQA2	-0.270430784883525
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1273	16/9376	0.920659858601728	ST8SIA1/ST3GAL1	-0.12589020990155
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1273	49/9376	0.901870881895571	NFKB1/GNAS/RELA/GNAI3/CREB1/ATF4	-0.272961796634471
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1273	33/9376	0.892761075007736	OGDH/IDH2/DLST/CS	-0.244592517935462
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/1273	89/9376	0.91031536580845	SLC38A1/GNB1/GNG2/GLS/GABARAPL1/PRKCB/GNB5/GNAI3/GABBR1/TRAK2/GNAO1	-0.336939744487081
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/1273	17/9376	0.866503396331038	MTR/TXNRD1	-0.21835184928392
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1273	17/9376	0.866503396331038	GLUD1/CA5B	-0.21835184928392
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	2/1273	17/9376	0.866503396331038	MYH9/MYH11	-0.21835184928392
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	3/1273	26/9376	0.849839869478518	ABCC1/LMBRD1/BTD	-0.303887213040822
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1273	59/9376	0.873846645452488	PIK3R1/AKT3/PIK3CB/GNAS/PIK3CA/GNAI3/AKT2	-0.38526865963678
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1273	76/9376	0.872204076570058	UBC/SLC27A4/HMGCS1/PLIN2/SORBS1/ACSL5/ACSL4/CPT1A/APOA2	-0.443362791543395
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1273	18/9376	0.818364318757092	ACSL5/ACSL4	-0.305719274163528
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	5/1273	44/9376	0.836963507819753	MAN2A1/STT3B/ALG13/FUT8/MAN1A2	-0.429636051318247
Organismal Systems	Digestive system	hsa04970	Salivary secretion	11/1273	93/9376	0.87116201674142	ATP2B4/CALM1/ITPR1/VAMP2/SLC12A2/PRKCB/GNAS/ATP1A1/SLC9A1/ATP1B3/ITPR3	-0.494900779298796
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1273	36/9376	0.818364318757092	GYG1/UGP2/HK1/GPI	-0.432768756877721
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	29/1273	235/9376	0.908906754023834	RPS6KA3/MAP3K5/SMARCA2/SOS1/PRKAG2/KRAS/MAP2K3/SMARCC1/KDM3A/SDHA/ARID1A/GNAS/ACSL5/COX19/ARID1B/ACSL4/PRKAA1/RPS6KB1/RHEB/NDUFA10/CREB1/CPT1A/COX20/GRB2/SMARCA4/SOS2/NDUFS5/NDUFA6/MAPK14	-0.560531695572
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	25/1273	205/9376	0.898204740099247	TGFB1/PIK3R1/SMAD3/AKT3/RAC2/NFKB1/PIK3CB/GSK3B/ATP2A3/PRKCB/GFPT1/SDHA/GAPDH/RELA/VDAC1/ATP2A2/PPP1CC/PIK3CA/SMAD2/MAPK8/NDUFA10/NDUFS5/AKT2/NDUFA6/MAPK14	-0.584080974351921
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	2/1273	19/9376	0.775292512506718	IDS/HGSNAT	-0.388600137674464
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1273	19/9376	0.775292512506718	OGDH/DLST	-0.388600137674464
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1273	37/9376	0.796246364196089	IFNG/TNF/PRKCB/FAS	-0.492190199743934
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	3/1273	29/9376	0.76192540022212	RASSF2/PAK1/LATS1	-0.508923916967725
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1273	29/9376	0.76192540022212	CALM1/GNB1/SLC24A1	-0.508923916967725
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	3/1273	30/9376	0.736527886881383	PGAP1/PIGB/PIGA	-0.572874266521733
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	7/1273	65/9376	0.793183878179951	LPIN1/AGPAT3/LPIN2/DGKZ/DGKD/GPAT4/AGPAT4	-0.6631622946745
NA	NA	hsa03272	Virion - Hepatitis viruses	5/1273	48/9376	0.767216548834774	LDLR/IST1/SLC10A1/CHMP4A/VPS4B	-0.640848501515749
NA	NA	hsa04981	Folate transport and metabolism	3/1273	31/9376	0.712768922788435	ABCC1/ABCC4/MTR	-0.634891542217064
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1273	23/9376	0.640459032070767	GLS/GLUD1	-0.684248343460853
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	4/1273	43/9376	0.685142220354774	ACSL5/ACSL4/CPT1A/ECI2	-0.820190895220084
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	22/1273	195/9376	0.830954539045662	PIK3R1/ITGAL/MAPK1/AKT3/RAC2/NFKB1/HDAC4/MAP2K1/PIK3CB/PRKCB/PLCG2/RAF1/RELA/VDAC1/PIK3CA/HMGB1/ITGB2/VWF/AKT2/CASP4/MAPK14/MAP2K2	-0.945480870892443
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	9/1273	89/9376	0.744803481116005	CD44/ITGA5/ITGB1/ITGA1/TNC/CD47/ITGB7/ITGA4/VWF	-0.958757881345831
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	5/1273	54/9376	0.68197026563091	LDHA/MAT2A/MTR/AMD1/DNMT1	-0.928938532132406
Organismal Systems	Digestive system	hsa04976	Bile secretion	9/1273	90/9376	0.736527886881383	LDLR/GNAS/SLC10A1/ATP1A1/ABCC4/SLC9A1/SLC4A4/ATP1B3/ABCB1	-0.995447797998229
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1273	36/9376	0.613773239067819	MCM6/RFC1/POLE4	-0.920231498887033
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	5/1273	55/9376	0.669570806255802	CERK/B4GALT5/SAMD8/CERS5/SMPD4	-0.974104213780394
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	34/1273	298/9376	0.840333830670034	IL32/CCL5/CXCR4/TGFB1/IL2RG/IFNG/TNFRSF1B/CXCR3/TNFSF14/TNF/CCL21/IL4R/XCL2/IL21R/IL2RB/IL10RA/RELL1/FAS/IL1RL1/CD40LG/TNFRSF18/TNFRSF4/CCL20/XCL1/TNFSF8/IL18R1/IL27RA/TNFRSF10A/CXCR6/CD70/IL18RAP/IFNGR1/CCL14/TNFRSF9	-1.11020420861009
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	5/1273	56/9376	0.65761418471552	MAN2A1/STT3B/ALG13/FUT8/MAN1A2	-1.01854153060651
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	3/1273	37/9376	0.597184773147067	GLS/GLUD1/GFPT1	-0.973046229002986
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/1273	27/9376	0.545576212504728	OXCT1/HMGCS1	-0.937210789828876
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	2/1273	27/9376	0.545576212504728	ELOVL5/ACOT7	-0.937210789828876
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	3/1273	38/9376	0.581469384380039	SIRT2/PNP/SIRT1	-1.02463459816764
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	28/1273	254/9376	0.811920505223571	CXCR4/ATP2B4/CAMK1D/CALM1/ITPKB/STIM2/ITPR1/NFATC2/PTK2B/MCOLN2/NFATC1/STIM1/PPP3CC/ATP2A3/PRKCB/PLCG2/ORAI1/GNAS/F2R/VDAC1/ORAI2/ATP2A2/MCU/PPP3CB/NFATC3/PPP3CA/CAMK4/ITPR3	-1.20445393393289
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	2/1273	28/9376	0.526091347772416	ELOVL5/ACOT7	-0.995385298652564
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/1273	28/9376	0.526091347772416	ST8SIA1/B3GNT2	-0.995385298652564
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	8/1273	86/9376	0.685142220354774	VAMP2/PRKCB/GNAS/ATP1A1/ATP1B3/CREB1/ATF4/ITPR3	-1.16260642234261
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	3/1273	39/9376	0.566559912985679	MTHFD2/MAT2A/MTR	-1.07506474362932
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	8/1273	87/9376	0.677267022419662	TPM2/ATP2A3/TPM4/TPM3/ATP1A1/SLC9A1/ATP2A2/ATP1B3	-1.19865833680389
Human Diseases	Substance dependence	hsa05034	Alcoholism	20/1273	191/9376	0.771233389404589	CALM1/GNB1/GNG2/BRAF/MAPK1/SOS1/KRAS/HDAC4/MAP2K1/RAF1/GNAS/GNB5/PPP1CC/GNAI3/CREB1/GRB2/SOS2/ATF4/CAMK4/GNAO1	-1.26603776800991
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	4/1273	51/9376	0.577668930887359	SLC12A2/PLCG2/GNAS/ERO1A	-1.19864511611864
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	2/1273	31/9376	0.475179281858956	PFKP/GPI	-1.16005635031827
NA	NA	hsa04519	Cadherin signaling	45/1273	404/9376	0.820389973011441	ACTN4/DES/EVL/YWHAZ/VIM/MYO1D/MAPK1/PTK2B/MYO1F/RAC2/YWHAQ/CYFIP2/NFKB1/KRAS/MAP2K1/GSK3B/CREBBP/MAP2K3/ARPC5L/ARHGAP35/RAF1/RRAS2/RELA/EP300/MYO1G/ARPC2/CDH13/PSEN1/ROCK1/TMC8/PPP1CC/TMC6/MAPK8/YWHAB/ACTR3/NFKBIA/RHOA/LATS1/VAV1/SHOC2/CSNK1A1/YWHAG/TAOK1/MAPK14/MAP2K2	-1.46269423200384
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	4/1273	54/9376	0.545576212504728	REV3L/WDR48/USP1/FANCI	-1.32733427256208
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	14/1273	149/9376	0.692039625257675	GNB1/GNG2/ITPR1/MAPK1/PRKCB/GNB5/GNAI3/MAPK8/NDUFA10/NDUFS5/ITPR3/NDUFA6/MAPK14/GNAO1	-1.50187792478932
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1273	21/9376	0.350727565181611	PANK2	-1.18056971220279
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	7/1273	85/9376	0.606552377431727	UPP1/NT5C3A/GUK1/RRM1/ASMTL/PNP/ADK	-1.44424901093148
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1273	22/9376	0.334785403127901	CARNMT1	-1.23808752773969
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	4/1273	57/9376	0.516861675004479	ELOVL5/ACSL5/ACSL4/CPT1A	-1.45011078261265
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1273	23/9376	0.320229516035384	B3GALNT2	-1.29368241473367
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1273	23/9376	0.320229516035384	RFC1	-1.29368241473367
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	1/1273	23/9376	0.320229516035384	LNPEP	-1.29368241473367
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	25/1273	250/9376	0.736527886881383	IDS/OSBPL3/IGF2R/GGA2/MCOLN2/BORCS5/ABCA5/AP3M2/LITAF/NPC1/VPS13C/VPS13A/ARSG/CLTB/AP1G1/PLEKHM1/CTSW/GNPTAB/AP2B1/OSBP/HGSNAT/AP3D1/VPS26A/NCOA7/AP5Z1	-1.67356023171706
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	8/1273	99/9376	0.595174050005158	HLA-DPB1/ITGAL/HLA-DRB5/HLA-DPA1/HLA-DRB1/CFH/ITGB2/HLA-DQA2	-1.60494104266178
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	4/1273	59/9376	0.499340940258564	UPP1/NT5C3A/RRM1/ASMTL	-1.5289981433585
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	4/1273	59/9376	0.499340940258564	ODC1/GSTK1/IDH2/RRM1	-1.5289981433585
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1273	24/9376	0.306886619533909	XYLT1	-1.34751800038398
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	17/1273	183/9376	0.684206233714946	NOP58/XRN1/XPO1/SBDS/GNL3/NXT1/MDN1/GTPBP4/NOP56/GNL2/HEATR1/NAT10/NXF1/FCF1/RAN/LSG1/WDR43	-1.70992628459554
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	3/1273	50/9376	0.441916732128829	ODC1/OAT/AMD1	-1.56824249961859
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/1273	51/9376	0.433251698165519	PAFAH1B1/SELENOI/PAFAH1B2	-1.60852500264726
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	4/1273	63/9376	0.467636753575481	CDKN1A/GSK3B/DDB2/BAX	-1.68039143247263
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	12/1273	143/9376	0.618065359620741	IFNG/HLA-DPB1/ACTN4/TNF/HLA-DRB5/HLA-DPA1/CD40LG/HLA-DRB1/SSB/RO60/SNRPB/HLA-DQA2	-1.82415849891727
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/1273	41/9376	0.359281896039699	BABAM2/TOPBP1	-1.62959124694887
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/1273	28/9376	0.263045673886208	GCH1	-1.54787953025134
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	6/1273	88/9376	0.502178104691852	SERPINE1/CLU/F2R/CFH/ITGB2/VWF	-1.85964971207597
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	5/1273	79/9376	0.466156890431255	VAMP2/NAPA/DNM2/CLTB/AP2B1	-1.88856828525273
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	1/1273	31/9376	0.237589640929478	CS	-1.68522115841948
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/1273	32/9376	0.230164964650432	LDHA	-1.72895291779176
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/1273	47/9376	0.313416122077184	LDHA/PKM	-1.87025965014963
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	2/1273	48/9376	0.306886619533909	OXCT1/HMGCS1	-1.90812821542428
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1/1273	36/9376	0.204591079689273	UGP2	-1.89515698290566
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	2/1273	52/9376	0.283279956492839	LDLR/GNAS	-2.05412566999725
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	1/1273	41/9376	0.179640948019849	PGAM1	-2.08648689993151
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	8/1273	128/9376	0.460329929300864	PDE7A/PDE4B/PDE4A/PDE8A/GUK1/RRM1/PNP/ADK	-2.43661171690208
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	1/1273	42/9376	0.175363782590805	DLST	-2.12290261628446
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	1/1273	43/9376	0.171285555088694	SLC27A4	-2.15876527878553
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	1/1273	46/9376	0.160114758017692	HMOX2	-2.26326269291345
NA	NA	hsa04081	Hormone signaling	16/1273	219/9376	0.538102565758088	PIK3R1/GNB1/GNG2/STAT5B/ESR2/PIK3CB/STAT3/ADIPOR2/STAT5A/GNAS/GNB5/PIK3CA/GNAI3/RHOA/GNA13/GNAO1	-2.74137167231331
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	4/1273	103/9376	0.286030247332576	SLC3A2/ATP1A1/COL18A1/ATP1B3	-2.8877873944241
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	1/1273	63/9376	0.11690918839387	PTGES3	-2.7874543253779
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2/1273	82/9376	0.179640948019849	UPP1/RRM1	-2.95723942353821
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1273	86/9376	0.171285555088694	GABBR1/ITPR3	-3.06001248254875
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1/1273	68/9376	0.10831292454138	DHRS3	-2.92493124266795
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	1/1273	70/9376	0.105218269554483	GSTK1	-2.97825256589897
NA	NA	hsa04382	Cornified envelope formation	12/1273	217/9376	0.407296527307677	PPP2R5C/S100A4/PPP2R2B/PPP2R2A/PPP2R5A/PPP2CA/PLEC/SLC27A4/PPP2R2D/PPP2R5E/PPP2R3C/S100A10	-3.50122668471127
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1/1273	73/9376	0.100894231079641	GSTK1	-3.05659307180155
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	5/1273	138/9376	0.266857930029486	SDHA/CYCS/NDUFA10/NDUFS5/NDUFA6	-3.43886895287686
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	6/1273	154/9376	0.286958916966772	GCH1/MTHFD2/PANK2/DHRS3/MAT2A/UGP2	-3.53621999289652
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1/1273	79/9376	0.093231378086251	GSTK1	-3.20786094399914
NA	NA	hsa04082	Neuroactive ligand signaling	8/1273	199/9376	0.296091612816636	GNB1/GNG2/PRKCB/GNAS/GNB5/GNAI3/GABBR1/GNAO1	-3.97804079799966
Genetic Information Processing	Translation	hsa03010	Ribosome	9/1273	222/9376	0.298592386573533	RPS26/RPS4Y1/RPL36AL/MRPS6/MRPL47/MRPL1/RSL24D1/MRPL10/RPL28	-4.19197254273128
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9/1273	370/9376	0.17915543194412	GZMA/NR3C1/P2RY10/PTGER4/F2R/P2RY8/PTGER2/GABBR1/TSPO	-6.38517404882356
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	3/1273	449/9376	0.0492112173862839	CALM1/GNB1/GRK2	-8.18335464907017