category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	104/1711	205/9376	2.78001454006358	NFKBIA/TNFAIP3/NFKB1/CD44/MAP2K3/CDKN1A/HLA-DRB5/HLA-B/TRAF3/HLA-A/TAB2/NCOR2/VIM/JAK1/TLR2/HLA-DQA1/BID/TBK1/CD58/PIK3R1/EIF2AK2/STAT1/HLA-DPB1/LYN/RELB/PLCG2/HLA-DRB1/PIK3CB/HLA-DQA2/HLA-DQB1/BCL2/HLA-F/ICAM1/IRAK1/NFKB2/HLA-DRA/BCL2L11/OAS2/IRF7/NFKBIE/STAT3/GADD45B/MAPK13/OAS3/MYD88/E2F3/HLA-DMB/HLA-E/HLA-DMA/HLA-DPA1/PSMD7/PSMD12/TAP1/IFNAR2/MAPK14/RIPK1/HLA-DOA/PSMD14/SIN3A/TAPBP/BTK/ISG15/TNF/PSMD1/IFNAR1/GADD45A/SYK/MAPK8/RELA/CYCS/NFKBIB/SAP30/USP7/AKT3/TYK2/SNW1/IRF9/STAT2/RUNX3/HLA-C/CDKN1B/PSMD11/TAP2/HES1/IL6/HLA-DQB2/MDM2/OAS1/CHUK/MAP2K4/IKBKE/ENTPD1/PIK3CD/TRAF6/RAC1/CASP9/PDIA3/CCND3/CASP8/JAK3/CASP3/IKBKG/APAF1/FAS	12.1743756196651
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	91/1711	180/9376	2.77036171179947	NFKBIA/NFKB1/ITGA5/HLA-DRB5/HLA-B/TRAF3/HLA-A/TAB2/JAK1/TLR2/HLA-DQA1/BID/IFIH1/TBK1/PIK3R1/C3/EIF2AK2/STAT1/HLA-DPB1/HLA-DRB1/BIRC2/PIK3CB/PILRA/TNFSF14/IL1B/HLA-DQA2/HLA-DQB1/BCL2/HLA-F/ZC3HAV1/SRPK1/IRAK1/IFNGR2/SRC/NXF1/TICAM1/HLA-DRA/SP100/OAS2/RHEB/IRF7/IFNGR1/OAS3/CGAS/MYD88/CD74/HLA-DMB/HLA-E/HLA-DMA/HLA-DPA1/TAP1/IFNAR2/HLA-DOA/BIRC3/PILRB/TAPBP/TNF/IFNAR1/SYK/SRSF5/RELA/SRSF2/CYCS/AKT3/TYK2/IRF9/STAT2/SRSF4/PPP1CB/POU2F1/HLA-C/TAP2/IL6/HLA-DQB2/TNFRSF14/PTPN11/OAS1/SRSF3/CHUK/PML/IKBKE/PIK3CD/TRAF6/CASP9/PDIA3/CASP8/CASP3/IKBKG/APAF1/FAS/DAXX	11.330611347407
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	90/1711	181/9376	2.72478050702151	RAB7A/IRAK2/NFKB1/ITGAX/HLA-DRB5/SPHK1/JAK1/ATP6V1H/TLR2/HLA-DQA1/BID/C3/STAT1/HLA-DPB1/VDR/IL1A/TGFB1/HLA-DRB1/CREBBP/PLK3/IL1B/HLA-DQA2/EP300/HLA-DQB1/CIITA/BCL2/ATP6V0D1/RAB5A/IL10/IL18/IRAK1/IFNGR2/SRC/RAF1/HLA-DRA/CLEC4E/HSPA9/IFNGR1/MAPK13/MYD88/CD74/HLA-DMB/HLA-DMA/HLA-DPA1/MALT1/LAMP2/IL10RA/MAPK1/CTSD/MAPK14/LSP1/HLA-DOA/FCGR3B/CAMP/TCIRG1/CEBPB/TNF/RIPK2/SYK/NOD2/MAPK8/RELA/FCGR2B/CYCS/IL10RB/PPP3R1/AKT3/CTSS/TLR1/BCL10/CLEC7A/RHOA/IL6/HLA-DQB2/NFYC/CASP10/ITGB2/ATP6V0B/PPP3CA/TRAF6/RFX5/ITGAM/CASP9/PPP3CC/ATP6V0C/TLR6/CASP8/CASP3/TLR4/APAF1	11.0701070162726
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	85/1711	173/9376	2.69240514454245	CXCL8/NFKBIA/NFKB1/HLA-DRB5/TRAF3/MX1/JAK1/MAP2K1/MX2/HLA-DQA1/BID/IFIH1/TBK1/DNAJC3/PIK3R1/EIF2AK2/STAT1/HLA-DPB1/IL1A/HLA-DRB1/CREBBP/TRIM25/PIK3CB/NUP98/IL1B/HLA-DQA2/HNRNPUL1/EP300/HLA-DQB1/CIITA/ADAR/ICAM1/IL18/IFNGR2/RAF1/NXF1/RSAD2/TICAM1/HLA-DRA/OAS2/IRF7/PRKCB/IFNGR1/OAS3/MYD88/HLA-DMB/HLA-DMA/HLA-DPA1/DNAJB1/MAPK1/IFNAR2/HLA-DOA/KPNA1/TNFRSF10B/TNF/IFNAR1/NLRP3/RELA/CYCS/NFKBIB/KPNA2/AKT3/TYK2/IRF9/STAT2/NXT1/IL6/HLA-DQB2/TNFRSF10A/OAS1/CHUK/PML/IKBKE/PIK3CD/CALCOCO2/KPNA6/CASP9/CCND3/CASP8/CASP3/TLR4/IKBKG/APAF1/NXT2/FAS	10.6149325953561
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	92/1711	196/9376	2.57216808406589	CXCL8/PIK3R5/NFKBIA/NFKB1/PTGS2/CXCL2/VEGFA/CDKN1A/HIF1A/MAPKAPK2/HLA-B/TRAF3/HLA-A/CXCL3/JAK1/MAP2K1/BID/TBK1/PIK3R1/C3/EIF2AK2/STAT1/MAP1LC3B/LYN/PLCG2/CREBBP/PIK3CB/PREX1/EP300/GNB1/CLEC2B/HLA-F/ATG3/ICAM1/SRC/HCK/RAF1/TICAM1/UBC/IRF7/STAT3/IFNGR1/MAPK13/CXCL1/E2F3/HLA-E/PIK3CG/MAPK1/IFNAR2/MAPK14/KRAS/ITPR1/NFATC1/IFNAR1/SYK/GNG7/MAPK8/TCF7L2/RELA/GSK3B/PIK3R6/CYCS/PPP3R1/AKT3/TYK2/IRF9/BECN1/STAT2/CCR5/ZFP36/HLA-C/IL6/TCF7/NRAS/PPP3CA/CHUK/CTNNB1/MAP2K4/IKBKE/PIK3CD/MAP1LC3A/RAC1/CASP9/PPP3CC/CASP8/GNG5/CASP3/MAP1LC3B2/CSF2/IKBKG/GNGT2/FAS	10.5089719791981
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	64/1711	112/9376	3.13133505886282	PIK3R5/NFKBIA/NFKB1/MAP2K3/PPIF/HLA-DRB5/TAB2/JAK1/TLR2/HLA-DQA1/STAT1/HLA-DPB1/TGFB1/HLA-DRB1/BIRC2/HLA-DQA2/HLA-DQB1/CIITA/BCL2/IL10/IRAK1/IFNGR2/HLA-DRA/STAT3/LAMB3/IFNGR1/MAPK13/MYD88/HLA-DMB/HLA-DMA/PIK3CG/HLA-DPA1/IL10RA/MAPK1/GNAI3/MAPK14/HLA-DOA/BIRC3/PDPK1/HSPA6/TNF/MAPK8/RELA/PIK3R6/CYCS/NFKBIB/IL10RB/ALOX5/AKT3/TYK2/SOCS1/CCR5/LDLR/HLA-DQB2/HSPA8/CHUK/TRAF6/ITGB1/CASP9/CASP8/CASP3/XIAP/TLR4/IKBKG	10.7205244178722
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	95/1711	216/9376	2.41011321081456	SOD2/CXCL8/NFKBIA/NFKB1/CXCL2/OLR1/MAP2K3/NFE2L2/ERN1/ABCG1/EIF2AK3/TRAF3/CXCL3/TAB2/TLR2/BID/TBK1/PIK3R1/LYN/VAV1/ABCA1/PIK3CB/IL1B/TANK/NCF2/BCL2/ICAM1/IL18/IRAK1/DDIT3/SRC/MMP9/TICAM1/IRF7/STAT3/MAPK13/CXCL1/ERO1A/MYD88/PPARG/ATF4/HSPA5/MAPK1/MAPK14/KRAS/RXRA/TNFRSF10B/RAP1A/PDPK1/HSPA6/ITPR1/RAP1B/TNF/NFATC1/NLRP3/MAPK8/RELA/GSK3B/CYCS/PPP3R1/AKT3/LDLR/POU2F1/RHOA/IL6/XBP1/PLCB2/TNFRSF10A/NCF1/NRAS/VAV2/HSPA8/CDC42/PPP3CA/CHUK/MAP2K4/IKBKE/ATF6/CCL3L1/PIK3CD/TRAF6/APOA1/RAC1/APOB/CASP9/PPP3CC/TLR6/CASP8/CASP3/TLR4/VAV3/IKBKG/MAP3K5/APAF1/FAS	9.90575730675688
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	78/1711	163/9376	2.62225297874095	CXCL8/NFKBIA/NFKB1/PTK2B/MAP2K3/CDKN1A/TRAF3/TAB2/BRAF/JAK1/MAP2K1/TLR2/BID/IFIH1/TBK1/GRB2/PIK3R1/STAT1/TGFB1/CREBBP/PIK3CB/EP300/STAT4/BCL2/YWHAZ/IRAK1/SRC/RAF1/MMP9/TICAM1/SMAD3/IRF7/STAT3/PRKCB/MAPK13/STAT5B/MYD88/E2F3/EGR3/ATF4/SOS2/MAPK1/MAPK14/KRAS/CREB5/DDX3X/TNF/NFATC1/IFNAR1/STAT5A/MAPK8/RELA/CYCS/AKT3/TYK2/STAT2/STAT6/IL6/YWHAQ/TGFBR1/CASP10/NRAS/ATF2/CHUK/MAP2K4/IKBKE/PIK3CD/TRAF6/ARAF/CASP9/CASP8/JAK3/CASP3/TLR4/IKBKG/APAF1/FAS/SLC10A1	9.87111951703251
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	69/1711	142/9376	2.6627373828006	NFKBIA/NFKB1/GAB2/LCP2/TAB2/JAK1/SQSTM1/MAP2K1/GRB2/PIK3R1/STAT1/FOSL2/CYLD/RELB/IL1A/TGFB1/PLCG2/PIK3CB/IL1B/FOSL1/NCF2/SIRPA/TREM2/IFNGR2/NFKB2/ACP5/LILRB1/ATP2A2/IL1R1/IFNGR1/MAPK13/ATP2A3/PPARG/MAPK1/IFNAR2/MAPK14/FCGR3B/ITPR1/BTK/SPI1/TNF/NFATC1/IFNAR1/SYK/MAPK8/RELA/FCGR2B/PPP3R1/AKT3/TYK2/LILRB2/IRF9/STAT2/SOCS1/TGFBR1/NCF1/LILRB3/PPP3CA/CHUK/LILRA6/LILRA1/TEC1/PIK3CD/TRAF6/RAC1/PPP3CC/IKBKG/FOSB/LILRA2	9.43251406504788
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	82/1711	187/9376	2.40292289276371	CXCL8/NAMPT/NFKBIA/TNFAIP3/NFKB1/CXCL2/TRAF3/CXCL3/TAB2/JAK1/GABARAPL1/TBK1/ERBIN/GBP2/STAT1/MAP1LC3B/BIRC2/IL1B/TANK/GBP5/BCL2/IL18/TICAM1/OAS2/IRF7/GBP1/MAPK13/CXCL1/OAS3/MYD88/TXN/MAPK1/MCU/IFNAR2/MAPK14/RIPK1/BIRC3/ITPR1/CAMP/P2RX7/TNF/IFNAR1/RIPK2/NLRP3/NOD2/GBP4/MAPK8/GPSM3/RELA/NFKBIB/ATG16L1/TYK2/TRPM2/IRF9/STAT2/PRKCD/RHOA/IL6/DNM1L/ATG12/PLCB2/MFN2/NLRC4/MFN1/MEFV/OAS1/PANX1/CHUK/TRPM7/IKBKE/DEFA4/TAB3/MAP1LC3A/TRAF6/NEK7/CASP8/MAP1LC3B2/DEFA3/XIAP/TLR4/IKBKG/GBP3	9.15535192537069
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	55/1711	105/9376	2.87039047062425	NFKBIA/NFKB1/PTGS2/MAPKAPK2/PAK1/PIK3R1/STAT1/CYLD/RELB/PLCG2/PIK3CB/PLK3/IL1B/IL10/BCL3/SRC/NFKB2/RAF1/MRAS/CLEC4E/IRF1/MAPK13/EGR3/MALT1/MAPK1/MAPK14/LSP1/KRAS/ITPR1/TNF/NFATC1/SYK/NLRP3/MAPK8/RELA/PPP3R1/AKT3/IRF9/STAT2/PRKCD/BCL10/CLEC7A/RHOA/IL6/MDM2/PTPN11/NRAS/PPP3CA/CHUK/IKBKE/PIK3CD/CLEC4D/PPP3CC/CASP8/IKBKG	9.10580201917934
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	45/1711	78/9376	3.16144404981342	NFKBIA/NFKB1/PTGS2/HLA-DRB5/TAB2/JAK1/TLR2/HLA-DQA1/C3/STAT1/HLA-DPB1/IL1A/TGFB1/HLA-DRB1/IL1B/HLA-DQA2/NCF2/HLA-DQB1/IL10/IRAK1/IFNGR2/HLA-DRA/PRKCB/IFNGR1/MAPK13/MYD88/HLA-DMB/HLA-DMA/HLA-DPA1/MAPK1/MARCKSL1/MAPK14/HLA-DOA/FCGR3B/TNF/RELA/NFKBIB/ITGA4/HLA-DQB2/NCF1/ITGB2/TRAF6/ITGAM/ITGB1/TLR4	9.05630607418338
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	49/1711	91/9376	2.9506811131592	NFKBIA/NFKB1/MAP2K1/PIK3AP1/GRB2/PIK3R1/LYN/PLCG2/VAV1/PIK3CB/RASGRP3/CD22/RAF1/CD72/LILRB1/NFKBIE/PRKCB/MALT1/SOS2/MAPK1/KRAS/BTK/NFATC1/SYK/RELA/GSK3B/IFITM1/FCGR2B/NFKBIB/PPP3R1/AKT3/INPP5D/LILRB2/RAC2/BCL10/LILRB3/NRAS/VAV2/PPP3CA/CHUK/LILRA6/LILRA1/PIK3CD/RAC1/PPP3CC/VAV3/IKBKG/LILRA2/DAPP1	8.83426829522693
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	57/1711	119/9376	2.62479556404678	NFKBIA/TNFAIP3/NFKB1/PTGS2/CXCL2/MAP2K3/TRAF3/CXCL3/TAB2/TRAF1/CFLAR/CCL20/MAP2K1/MAP3K8/PIK3R1/CYLD/BIRC2/PIK3CB/IL1B/TNFRSF1B/ADAM17/ICAM1/BCL3/MMP9/IRF1/MAPK13/CXCL1/ATF4/MAPK1/MAPK14/RIPK1/CREB5/BIRC3/CEBPB/TNF/RHBDF2/NOD2/MAPK8/RELA/AKT3/IL6/DNM1L/FRMD8/CASP10/ATF2/CHUK/MAP2K4/TAB3/PIK3CD/MLKL/CASP8/CASP3/CSF2/XIAP/IKBKG/MAP3K5/FAS	8.42736175419441
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	72/1711	169/9376	2.3346048367853	RAB7A/HIF1A/ERN1/C9orf72/EIF2AK3/IRS2/CFLAR/SQSTM1/MAP2K1/GABARAPL1/TBK1/PIK3R1/MAP1LC3B/RAB1A/RB1CC1/PIK3CB/MTMR3/CAMKK2/TANK/BCL2/PPP2CA/ATG3/RAF1/MRAS/UBC/RHEB/ATG7/WDR45B/EPG5/ATG4B/RPTOR/PTEN/TP53INP2/RRAGD/LAMP2/MAPK1/ATG2A/CTSD/TAX1BP1/KRAS/RAB8A/DDIT4/PDPK1/ITPR1/PLEKHM1/RRAGC/MAPK8/BIRC6/AKT3/ATG16L1/VMP1/BECN1/NRBF2/PRKCD/WDFY3/RAB7B/ATG12/MTMR14/NRAS/SH3GLB1/IGF1R/PIK3CD/MAP1LC3A/WIPI1/CALCOCO2/TRAF6/ZFYVE1/MAP1LC3B2/ATG13/VPS18/SMCR8/UVRAG	8.27163835929833
Human Diseases	Infectious disease: viral	hsa05162	Measles	62/1711	136/9376	2.49816069034276	NFKBIA/TNFAIP3/NFKB1/TRAF3/TAB2/MX1/JAK1/MX2/TLR2/BID/IFIH1/TBK1/PIK3R1/EIF2AK2/STAT1/IL1A/PIK3CB/IL1B/ADAR/BCL2/IRAK1/OAS2/IRF7/STAT3/STAT5B/OAS3/MYD88/IFNAR2/IL2RG/HSPA6/MSN/IFNAR1/STAT5A/MAPK8/RELA/GSK3B/FCGR2B/CYCS/NFKBIB/AKT3/TYK2/IRF9/STAT2/CDKN1B/CD46/IL6/OAS1/HSPA8/CHUK/IKBKE/PIK3CD/TRAF6/CASP9/CCND3/RCHY1/CASP8/JAK3/CASP3/TLR4/IKBKG/APAF1/FAS	8.31469703919386
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	88/1711	227/9376	2.12434184610077	CXCL8/NFKBIA/NFKB1/PTGS2/PTK2B/VEGFA/CDKN1A/HLA-B/CXCR4/IL6R/HLA-A/ITGAV/JAK1/MAP2K1/GNA13/BID/TBK1/GRB2/AKAP13/PIK3R1/PIK3CB/IL1B/GNA12/GNB1/HLA-F/SRC/RAF1/PTGER4/RHEB/IL1R1/STAT3/PRKCB/MAPK13/CGAS/E2F3/HLA-E/ROCK1/ADCY3/ATF4/TAP1/SOS2/IL10RA/MAPK1/GNAI3/MAPK14/KRAS/RIPK1/CRK/CREB5/TAPBP/ITPR1/TNF/NFATC1/GNG7/GNAQ/RELA/GSK3B/CYCS/IL10RB/PPP3R1/AKT3/CCR5/PTGER2/RAC2/RHOA/HLA-C/TAP2/IL6/MDM2/PLCB2/NRAS/CXCR2/PPP3CA/ATF2/CHUK/CTNNB1/CCL3L1/PIK3CD/RAC1/CASP9/PDIA3/PPP3CC/CASP8/GNG5/CASP3/IKBKG/GNGT2/FAS	8.1017540116753
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	35/1711	56/9376	3.42489772063121	CXCL8/NFKBIA/NFKB1/CXCL2/CXCL3/TLR2/C3/RAB1A/IL1B/CLK1/IL18/NFKB2/CXCL1/MYD88/HBS1L/SEC22B/HSPA6/TNF/RELA/CYCS/BCL2L13/IL6/SAR1B/SAR1A/NLRC4/ITGB2/ARF1/HSPA8/ITGAM/CASP9/CASP8/CASP3/TLR4/APAF1/CLK4	8.5987247267871
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	62/1711	138/9376	2.46195546294649	CXCL8/NFKBIA/NFKB1/PTK2B/MAP2K3/LCP2/ITGA5/TAB2/MAP2K1/TBK1/PIK3R1/ACTR3/VAV1/PIK3CB/IL1B/IL10/IL18/IRAK1/SRC/TICAM1/MAPK13/RPS6KA3/MYD88/ROCK1/MAPK1/MAPK14/CRK/WIPF1/TNF/NFATC1/WIPF2/NLRP3/GNAQ/MAPK8/RELA/GSK3B/ITGA4/RPS6KA1/AKT3/PIP5K1A/RAC2/ARHGEF7/RHOA/SKAP2/IL6/FYB1/NLRC4/ACTR2/MEFV/VAV2/CDC42/CHUK/MAP2K4/PIK3CD/TRAF6/ITGB1/RAC1/TLR4/VAV3/IKBKG/ARPC2/ARPC5	8.17408726949327
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	67/1711	155/9376	2.3687034558172	RAB7A/OLR1/ITGA5/HLA-DRB5/HLA-B/HLA-A/ITGAV/ATP6V1H/TLR2/HLA-DQA1/C3/HLA-DPB1/HLA-DRB1/HLA-DQA2/NCF2/HLA-DQB1/DYNC1H1/HLA-F/ATP6V0D1/RAB5A/HLA-DRA/TUBA1C/ATP6V1B2/TUBB4B/HLA-DMB/HLA-E/HLA-DMA/DYNC1LI1/HLA-DPA1/TUBA4A/TAP1/LAMP2/M6PR/FCAR/SEC22B/HLA-DOA/FCGR3B/TCIRG1/MSR1/ATP6V1E1/FCGR2B/TUBB6/ATP6V1F/ATP6V1A/CTSS/CLEC7A/ATP6V1C1/HLA-C/TAP2/RAB7B/HLA-DQB2/CANX/STX18/ATP6V1D/NCF1/HGS/ITGB2/ATP6V0B/TFRC/THBS1/ITGAM/ITGB1/MPO/RAC1/ATP6V0C/TLR6/TLR4	8.11784519615074
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	53/1711	109/9376	2.66450758449107	NFKBIA/NFKB1/HIF1A/HLA-DRB5/IL6R/JAK1/HLA-DQA1/STAT1/HLA-DPB1/TGFB1/HLA-DRB1/IL1B/HLA-DQA2/HLA-DQB1/RARA/IL4R/IFNGR2/SMAD3/HLA-DRA/IL1R1/NFKBIE/STAT3/IFNGR1/MAPK13/STAT5B/RUNX1/HLA-DMB/HLA-DMA/HLA-DPA1/MAPK1/MAPK14/RXRA/HLA-DOA/IL2RG/IL1RAP/NFATC1/AHR/STAT5A/MAPK8/RELA/NFKBIB/PPP3R1/TYK2/IRF4/STAT6/IL6/HLA-DQB2/TGFBR1/PPP3CA/CHUK/PPP3CC/JAK3/IKBKG	8.25817361975607
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	94/1711	253/9376	2.03598662918156	CXCL8/NFKBIA/NFKB1/CD44/ITGA5/FOXO3/TAB2/TNIP1/SQSTM1/TBK1/PIK3R1/C3/MAP1LC3B/ACTR3/CYTH1/ARHGEF2/PLCG2/PIK3CB/ACTN1/IL1B/BCL2/UBE2D1/UBE2D3/IL18/FNBP1/HK2/DIAPH1/SRC/UBC/SEPTIN6/FOXO1/IL1R1/CUL1/CAPN2/PRKCE/MAPK13/RPTOR/CGAS/UBE2N/MYD88/CAST/ROCK1/RRAGD/MALT1/MAPK1/HCLS1/MAPK14/RIPK1/CRK/TLN1/ITPR1/HK1/TNF/FBXW11/SEPTIN9/RIPK2/NLRP3/RRAGC/MAPK8/CBX3/RELA/GSK3B/CYCS/NFKBIB/AKT3/ATG16L1/BECN1/PPID/PRKCD/BCL10/RHOA/ATG12/MDM2/PLCB2/NLRC4/ACTR2/ARF1/CDC42/CHUK/CYTH3/TAB3/PIK3CD/MAP1LC3A/WIPI1/CALCOCO2/TRAF6/ITGB1/RAC1/MAP1LC3B2/CSF2/TLR4/IKBKG/ARPC2/ARPC5	7.89223733417357
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	92/1711	248/9376	2.03284251805207	CXCL8/NFKBIA/RAB7A/NFKB1/MAP2K3/ARL8B/TAB2/PAK1/MAP2K1/TLR2/ACTR3/CYTH1/BIRC2/PIK3CB/ABI1/DNM2/IL1B/RHOH/BCL2/DYNC1H1/RAB5A/KPNA4/PLEKHM2/IL18/IRAK1/RALA/RAF1/ACBD3/SNX9/TUBA1C/MAPK13/PTPRC/TUBB4B/MYD88/DYNC1LI1/PIK3CG/TXN/TUBA4A/MAPK1/M6PR/MAPK14/RIPK1/KPNA1/BIRC3/TNFRSF10B/PLEKHM1/FLNA/CYFIP2/TNF/RIPK2/NLRP3/MAPK8/TCF7L2/RELA/TUBB6/CYCS/AKT3/GCC2/DCTN4/KPNA3/ARL8A/SNX18/GAPDH/ACTR1A/RHOA/IL6/RAB7B/TNFRSF10A/NLRC4/TCF7/ACTR2/ARF1/RHOB/CDC42/CHUK/CTNNB1/ANXA2/MAP2K4/CYTH3/TAB3/PIK3CD/TRAF6/MLKL/RAC1/TLR6/CASP8/CASP3/VPS18/TLR4/IKBKG/ARPC2/ARPC5	7.78801350414539
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	59/1711	137/9376	2.35992952428895	BCL2A1/NFKBIA/NFKB1/ERN1/EIF2AK3/IL3RA/TRAF1/CFLAR/MAP2K1/BID/PIK3R1/BIRC2/PIK3CB/MCL1/PMAIP1/BCL2/DDIT3/RAF1/BCL2L11/CTSH/TUBA1C/CAPN2/GADD45B/ATF4/TUBA4A/MAPK1/CTSD/KRAS/RIPK1/BIRC3/TNFRSF10B/PDPK1/ITPR1/TNF/GADD45A/MAPK8/RELA/LMNA/CYCS/LMNB1/AKT3/CTSS/PARP4/TNFRSF10A/CASP10/NRAS/CHUK/CSF2RB/AIFM1/PIK3CD/CASP9/CASP8/CASP3/XIAP/IKBKG/MAP3K5/APAF1/FAS/DAXX	7.5756301861077
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	49/1711	105/9376	2.55725696473797	CXCL8/BCL2A1/NFKBIA/TNFAIP3/NFKB1/PTGS2/CXCL2/TRAF3/CXCL3/TAB2/TRAF1/CFLAR/CYLD/LYN/RELB/PLCG2/BIRC2/TRIM25/TNFSF14/IL1B/BCL2/ICAM1/IRAK1/NFKB2/PLAU/TICAM1/IL1R1/PRKCB/GADD45B/CXCL1/MYD88/MALT1/RIPK1/BIRC3/BTK/TNF/TNFSF13B/GADD45A/SYK/ERC1/RELA/CCL21/BCL10/CHUK/TAB3/TRAF6/XIAP/TLR4/IKBKG	7.58134402233103
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	64/1711	156/9376	2.24813799097844	NFKBIA/NFKB1/CDKN1A/TRAF3/BRAF/MX1/CFLAR/JAK1/MAP2K1/MX2/BID/TBK1/GRB2/PIK3R1/EIF2AK2/STAT1/PIK3CB/PPP2R2A/PIAS1/YWHAZ/PPP2CA/RAF1/RSAD2/TICAM1/OAS2/IRF7/STAT3/YWHAG/OAS3/E2F3/SOS2/MAPK1/IFNAR2/PPP2R2D/KRAS/RIPK1/RXRA/YWHAH/TNF/IFNAR1/RELA/GSK3B/CYCS/AKT3/TYK2/IRF9/STAT2/LDLR/IFIT1/YWHAQ/NRAS/OAS1/CHUK/CTNNB1/IKBKE/PIK3CD/TRAF6/ARAF/CASP9/CASP8/CASP3/IKBKG/APAF1/FAS	7.42700992919154
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	45/1711	93/9376	2.65153371919836	NFKBIA/NFKB1/HLA-DRB5/JAK1/HLA-DQA1/STAT1/HLA-DPB1/HLA-DRB1/HLA-DQA2/HLA-DQB1/STAT4/NOTCH2/IL4R/IFNGR2/HLA-DRA/NFKBIE/MAML3/IFNGR1/MAPK13/STAT5B/HLA-DMB/HLA-DMA/HLA-DPA1/MAPK1/MAPK14/HLA-DOA/IL2RG/NOTCH1/NFATC1/STAT5A/MAPK8/RELA/NFKBIB/MAML1/PPP3R1/TYK2/RUNX3/STAT6/HLA-DQB2/PPP3CA/CHUK/MAML2/PPP3CC/JAK3/IKBKG	7.5620458718152
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	45/1711	95/9376	2.59571195668892	CXCL8/CXCL2/VEGFA/HLA-DRB5/CXCL3/ATP6V1H/CCL20/TLR2/HLA-DQA1/HLA-DPB1/IL1A/TGFB1/HLA-DRB1/IL1B/HLA-DQA2/HLA-DQB1/ATP6V0D1/ICAM1/IL18/ACP5/HLA-DRA/ATP6V1B2/CXCL1/HLA-DMB/HLA-DMA/HLA-DPA1/CD80/HLA-DOA/TCIRG1/TNF/TNFSF13B/ATP6V1E1/ATP6V1F/ATP6V1A/ATP6V1C1/TNFSF13/IL6/HLA-DQB2/ATP6V1D/ITGB2/ATP6V0B/CCL3L1/ATP6V0C/CSF2/TLR4	7.385390763287
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	88/1711	250/9376	1.9289023962595	RAB7A/CHMP4B/HLA-B/CXCR4/EHD1/ARFGAP3/AGAP3/HLA-A/IGF2R/ZFYVE16/VPS37B/RAB31/ACTR3/CYTH1/SH3KBP1/DNM2/CHMP1B/ARFGEF1/HLA-F/RAB5A/SRC/PDCD6IP/SMAD3/IQSEC1/SMURF1/HLA-E/ACAP2/CBL/ARF4/ASAP1/ARAP1/CHMP2B/VPS4B/RAB8A/IL2RG/IST1/WIPF1/HSPA6/WASHC2C/SMURF2/RAB10/WIPF2/EPS15L1/SPART/WASHC2A/GBF1/WASHC5/SH3GL1/TSG101/STAM/RAB35/SMAP1/USP8/SPG21/CCR5/PIP5K1A/LDLR/RHOA/HLA-C/RUFY1/CAPZA1/VPS26A/MDM2/TGFBR1/RAB11FIP1/ACTR2/HGS/ARF1/SMAP2/HSPA8/CXCR2/EHD4/CDC42/ZFYVE27/TFRC/PML/ARFGEF2/SH3GLB1/IGF1R/CYTH3/VPS37C/TRAF6/PSD/SNX32/PRKCI/ARPC2/ARPC5/RAB11FIP2	7.03322350284152
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	37/1711	71/9376	2.85568936706152	CXCL8/NFKBIA/NFKB1/CXCL2/CXCL3/ATP6V1H/PAK1/LYN/HBEGF/PLCG2/ATP6V0D1/ADAM17/SRC/ATP6V1B2/MAPK13/CXCL1/MAPK14/TCIRG1/MAPK8/ATP6V1E1/RELA/ATP6V1F/ATP6V1A/ATP6V1C1/ATP6V1D/PTPN11/CXCR2/ATP6V0B/CDC42/CHUK/MAP2K4/RAC1/F11R/ATP6V0C/CASP3/IKBKG/MET	7.41533589655385
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	35/1711	66/9376	2.90597382356587	NFKB1/HLA-DRB5/TLR2/HLA-DQA1/STAT1/HLA-DPB1/IL1A/TGFB1/HLA-DRB1/IL1B/HLA-DQA2/HLA-DQB1/STAT4/IL10/IL18/IL4R/IFNGR2/SMAD3/HLA-DRA/STAT3/IFNGR1/HLA-DMB/HLA-DMA/HLA-DPA1/HLA-DOA/IL2RG/TNF/NFATC1/NOD2/RELA/STAT6/IL6/HLA-DQB2/IL18RAP/TLR4	7.34122647993685
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	72/1711	193/9376	2.04429128195189	CXCL8/PIK3R5/NFKBIA/NFKB1/CXCL2/PTK2B/FOXO3/CXCR4/CXCL3/BRAF/CCL20/PAK1/MAP2K1/GRB2/PIK3R1/STAT1/LYN/PLCG2/VAV1/PIK3CB/PREX1/GNB1/CXCL16/SRC/FGR/HCK/RAF1/STAT3/PRKCB/CXCL1/STAT5B/ROCK1/PIK3CG/ADCY3/SOS2/MAPK1/GNAI3/KRAS/CRK/RAP1A/DOCK2/RAP1B/GNG7/GNAQ/RELA/GSK3B/PIK3R6/NFKBIB/AKT3/CCL21/STAT2/CCR5/PRKCD/RAC2/RHOA/PLCB2/NCF1/NRAS/VAV2/CXCR2/CDC42/CHUK/CCL3L1/PIK3CD/RAC1/GNG5/JAK3/VAV3/RASGRP2/IKBKG/GNGT2/CCR7	6.92568250298502
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	76/1711	214/9376	1.94611010667643	NFKBIA/NFKB1/PTK2B/MAP2K3/HLA-B/CXCR4/HLA-A/TAB2/PAK1/MAP2K1/TLR2/BID/TBK1/PIK3R1/LIMK2/PLCG2/PIK3CB/GNB1/TNFRSF1B/AP1G1/BCL2/HLA-F/APOBEC3A/IRAK1/RAF1/CUL1/PRKCB/MAPK13/CGAS/MYD88/HLA-E/TAP1/MAPK1/GNAI3/MAPK14/KRAS/RIPK1/CRK/TAPBP/ITPR1/TNF/NFATC1/RNF7/CUL4A/FBXW11/AP1S3/GNG7/GNAQ/MAPK8/ELOC/RELA/CYCS/PPP3R1/AKT3/CCR5/RAC2/HLA-C/TAP2/NRAS/SAMHD1/PPP3CA/DCAF1/CHUK/PIK3CD/TRAF6/RAC1/CASP9/PDIA3/PPP3CC/CASP8/GNG5/CASP3/TLR4/IKBKG/GNGT2/FAS	6.61466703947999
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	57/1711	144/9376	2.1691018897331	CXCL8/NFKBIA/NFKB1/CXCL2/MAP2K3/FOXO3/TRAF3/CXCL3/TAB2/C5AR1/TBK1/C3/ADIPOR2/IL1B/CAMKK2/IRAK1/TICAM1/PRKAG2/FOXO1/MAPK13/CXCL1/MYD88/MAPK14/RIPK1/LPIN2/CPT1A/SIRT1/TNF/MAPK8/ACADVL/TCF7L2/RELA/LPIN1/GSK3B/TRA2A/AKT3/ACOX3/IL6/SREBF1/ALDH2/TCF7/IL17RA/CHUK/CTNNB1/MAP2K4/IKBKE/ALDH3A2/TAB3/TRAF6/ACOX1/CASP8/CASP3/TLR4/IKBKG/MAP3K5/SCD/FAS	6.6794433988781
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	73/1711	205/9376	1.95135635985232	NFKBIA/NFKB1/CDKN1A/MAPKAPK2/HLA-B/TRAF3/HLA-A/TRAF1/JAK1/REL/GRB2/PIK3R1/C3/EIF2AK2/LYN/CREBBP/PIK3CB/ACTN1/EP300/PMAIP1/HLA-F/ATP6V0D1/YWHAZ/SRC/NFKB2/MAD1L1/PKM/SP100/UBR4/IRF7/STAT3/CHD4/YWHAG/STAT5B/HLA-E/EGR3/ATF4/MAPK1/KRAS/CREB5/DDX3X/YWHAH/SYK/GTF2B/HDAC4/STAT5A/RELA/KAT2B/UBE3A/USP7/SNW1/GTF2A1/IRF9/CCR5/HDAC5/GTF2H1/RHOA/HLA-C/CDKN1B/YWHAQ/MDM2/NRAS/CDC42/ATF2/PIK3CD/RAC1/RASA2/CCND3/POLB/CASP8/JAK3/CASP3/IKBKG	6.50678374379218
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	60/1711	157/9376	2.09420497567259	RAB7A/PTGS2/HIF1A/MAPKAPK2/ITGAV/SPHK1/ATP11B/DUSP16/DUSP2/PPARD/GPR132/MAP2K1/SGK1/TGFB1/ABCA1/SIRPA/RAB5A/ADAM17/PLA2G6/IL10/PTGER4/ATP2A2/DUSP5/AXL/MAPK13/ATP2A3/PPARG/MAPK1/HAVCR2/MAPK14/RXRA/CRK/CPT1A/LIPA/HAVCR1/VPS8/SIRT1/CEBPB/NFATC1/ARG1/SLC16A1/TMEM30A/ATP11A/ALOX5/ATP11C/PTGER2/SCARF1/RAB7B/DUSP4/PTPN11/PANX1/CD24/ODC1/ATP8A1/THBS1/RAC1/CASP3/P2RY6/VPS18/SIGLEC10	6.53222548090098
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	84/1711	250/9376	1.84122501461134	LITAF/RAB7A/ARL8B/LAPTM5/IGF2R/MANBA/ATP6V1H/DMXL2/PSAP/SLC17A5/SLC11A1/BORCS5/AP1G1/BLOC1S6/ATP6V0D1/SLC36A4/GALC/CLN8/ARSG/AP5Z1/NPC1/GM2A/AP5B1/ACP5/CTSH/IDS/GGA2/BLOC1S2/ATP6V1B2/GNS/RPTOR/GLA/RRAGD/LAMP2/SLC15A3/M6PR/CTSD/AP3B1/SLC11A2/LAMTOR3/CTSA/ARSB/PLEKHM1/LIPA/AP3D1/TFE3/TCIRG1/ASAH1/AP1S3/HGSNAT/GGA1/TPCN2/RRAGC/DTNBP1/ATP6V1E1/AP3S1/GNPTAB/CLCN7/PPT1/TPP1/DNASE2/ATP6V1F/ATP6V1A/CTSS/HEXB/ARL8A/SLC15A4/ATP6V1C1/OSBP/HEXA/SORT1/VPS26A/OSTM1/ATP6V1D/ATP6V0B/TFEB/VPS13A/ENTPD4/CLN3/NCOA7/CTBS/ATP6V0C/VPS18/OSBPL2	6.3693705256519
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	96/1711	300/9376	1.75354763296318	NFKB1/MAP2K3/VEGFA/EREG/MAP3K2/MAPKAPK2/TAB2/BRAF/DUSP16/DUSP2/PAK1/MAP2K1/MAP3K8/GRB2/NR4A1/RELB/IL1A/TGFB1/IL1B/MAP4K4/GNA12/RASGRP3/DUSP10/IRAK1/DDIT3/NFKB2/RAF1/RAPGEF2/MRAS/DUSP5/IL1R1/PRKCB/GADD45B/MAPK13/RPS6KA3/MYD88/PTPN7/ATF4/SOS2/MAPK1/PPM1B/MAPK14/KRAS/CRK/LAMTOR3/RAP1A/STK4/HSPA6/FLNA/RAP1B/IL1RAP/TNF/NFATC1/MAP3K20/GADD45A/AREG/MAPK8/RELA/TAOK3/MAX/PPP3R1/RPS6KA1/AKT3/TAOK1/MKNK2/PLA2G4A/DUSP1/RAC2/MAPKAPK3/PPM1A/TGFBR1/DUSP4/NRAS/HSPA8/CDC42/PPP3CA/ATF2/CHUK/IGF1R/MAP2K4/TRAF6/ARAF/RAC1/RASA2/CACNA1G/PPP3CC/CASP3/MAP3K11/RASGRP2/IKBKG/MAP3K5/INSR/FAS/MAP3K12/MET/DAXX	6.26727363914911
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	34/1711	69/9376	2.70020921742519	GAB2/MAP2K3/LCP2/MAP2K1/ALOX5AP/GRB2/PIK3R1/LYN/PLCG2/VAV1/PIK3CB/RAF1/MAPK13/SOS2/MAPK1/MAPK14/KRAS/PDPK1/BTK/TNF/SYK/MAPK8/ALOX5/AKT3/INPP5D/PLA2G4A/RAC2/NRAS/VAV2/MAP2K4/PIK3CD/RAC1/CSF2/VAV3	6.69694324017692
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	46/1711	109/9376	2.31259148842621	CXCL8/NFKBIA/NFKB1/MAP2K3/TRAF3/TAB2/JAK1/MAP2K1/TLR2/MAP3K8/TBK1/PIK3R1/STAT1/PIK3CB/IL1B/IRAK1/TICAM1/IRF7/MAPK13/MYD88/MAPK1/IFNAR2/CD80/MAPK14/RIPK1/TNF/IFNAR1/MAPK8/RELA/AKT3/TYK2/IRF9/STAT2/TLR1/IL6/CHUK/MAP2K4/IKBKE/CCL3L1/PIK3CD/TRAF6/RAC1/TLR6/CASP8/TLR4/IKBKG	6.51220126855231
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	49/1711	120/9376	2.23759984414572	NFKBIA/IRAK2/NFKB1/FOXO3/RAPGEF1/MAPKAPK2/BRAF/MAP2K1/IRAK3/GRB2/PIK3R1/PLCG2/PSEN1/PIK3CB/BCL2/IRAK1/RAF1/SH2B3/NFKBIE/MAPK13/RPS6KA3/ATF4/SOS2/MAPK1/MAPK14/KRAS/CRK/RAP1A/PDPK1/RAP1B/RIPK2/MAPK8/RELA/GSK3B/NFKBIB/RPS6KA1/AKT3/PRKCD/RHOA/SH2B2/SORT1/PTPN11/NRAS/CDC42/ZNF274/PIK3CD/TRAF6/RAC1/MAP3K5	6.44634818762796
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	46/1711	110/9376	2.29156792944052	NFKB1/VEGFA/CDKN1A/HIF1A/PFKFB3/EIF4E/IL6R/MAP2K1/PIK3R1/PLCG2/CREBBP/PIK3CB/EP300/BCL2/HK2/IFNGR2/STAT3/PRKCB/IFNGR1/PGK1/MAPK1/LDHA/HK1/ELOC/RELA/VHL/ENO1/AKT3/MKNK2/HMOX1/EGLN1/GAPDH/CDKN1B/IL6/PDK1/PFKP/TFRC/TF/IGF1R/PIK3CD/ENO3/TIMP1/ALDOA/TLR4/INSR/ALDOC	6.43757068492611
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	39/1711	87/9376	2.45647836514238	CDKN1A/EREG/BRAF/RALGDS/MAP2K1/GRB2/PIK3R1/TGFB1/PIK3CB/PMAIP1/BCL2/RALA/RAF1/SMAD3/BCL2L11/GADD45B/SOS2/MAPK1/KRAS/GADD45A/AREG/MAPK8/TCF7L2/GSK3B/CYCS/AKT3/RAC2/RHOA/TGFBR1/TCF7/NRAS/CTNNB1/AXIN1/PIK3CD/RALB/ARAF/RAC1/CASP9/CASP3	6.44812942841877
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	71/1711	204/9376	1.90719794639071	PLAUR/CD44/VEGFA/CDKN1A/HIF1A/ITGA5/BRAF/ITGAV/PAK1/MAP2K1/TLR2/GRB2/PIK3R1/HBEGF/TGFB1/PLCG2/VAV1/PIK3CB/SLC9A1/DDX5/SRC/RAF1/PLAU/PPP1R12A/MMP9/MRAS/STAT3/PRKCB/MAPK13/HPSE/ROCK1/CBL/SOS2/MAPK1/EZR/SDC4/HCLS1/MAPK14/KRAS/PDPK1/ITPR1/FLNA/IQGAP1/TNF/MSN/AKT3/SDC2/PPP1CB/RDX/RHOA/MDM2/PPP1R12C/PDCD4/PTPN11/NRAS/VAV2/CDC42/WNT2B/CTNNB1/IGF1R/PIK3CD/THBS1/ARAF/ITGB1/RAC1/PPP1R12B/CASP3/TLR4/VAV3/FAS/MET	6.18927361677799
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	49/1711	122/9376	2.2009178794876	NFKBIA/NFKB1/LCP2/PAK1/MAP2K1/MAP3K8/GRB2/PIK3R1/VAV1/PIK3CB/PPP2R2A/PPP2CA/IL10/RAF1/NFKBIE/MAPK13/PTPRC/MALT1/SOS2/MAPK1/PPP2R2D/MAPK14/KRAS/PDPK1/TNF/NFATC1/PPP2R5C/MAPK8/RELA/GSK3B/NFKBIB/PPP3R1/AKT3/BCL10/RHOA/PPP2R5A/PPP2R3C/PTPN11/NRAS/VAV2/CDC42/PPP3CA/CHUK/TEC1/PIK3CD/PPP3CC/CSF2/VAV3/IKBKG	6.30787446716149
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	63/1711	174/9376	1.98407867953808	PPP1R15A/NFE2L2/ERN1/EIF2AK3/EDEM1/DNAJC3/STT3B/SEC24A/BCL2/UBE2D1/UBE2D3/ERO1B/DNAJC5/DDIT3/CUL1/CAPN2/ERO1A/ATF4/DNAJB1/HSPA5/MAGT1/UBQLN1/UBE2G1/SEC24D/HSPA6/PLAA/SSR1/OS9/UBE2J1/SEC63/MAPK8/NGLY1/SEL1L/HERPUD1/NPLOC4/SEC13/UBXN4/UFD1/HYOU1/RAD23B/DERL1/SEC31A/RNF185/HSPH1/SVIP/XBP1/SAR1B/CKAP4/DNAJA2/CANX/SAR1A/DNAJB11/SEC24C/DNAJC1/HSPA8/DNAJA1/ATF6/DNAJB2/PDIA3/SEC24B/EDEM3/SEC23B/MAP3K5	6.19038836052143
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	43/1711	103/9376	2.28769867164492	CXCL8/NFKBIA/NFKB1/CFLAR/TLR2/PIK3R1/C3/TGFB1/PIK3CB/IL1B/PPP2R2A/PPP2CA/IL10/IRAK1/IFNGR2/TICAM1/GNA15/IFNGR1/MAPK13/MYD88/MAPK1/GNAI3/PPP2R2D/MAPK14/GNAL/TNF/GNAQ/MAPK8/RELA/AKT3/IL6/PLCB2/TGFBR1/CHUK/MAP2K4/CCL3L1/PIK3CD/TRAF6/TLR6/CASP8/TLR4/IKBKG/FAS	6.20836573815428
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	75/1711	224/9376	1.83476663605243	NFKBIA/NFKB1/ETS2/CDKN1A/HLA-DRB5/HLA-B/HLA-A/JAK1/MAP2K1/HLA-DQA1/PIK3R1/HLA-DPB1/RELB/TGFB1/HLA-DRB1/CREBBP/PIK3CB/FOSL1/HLA-DQA2/EP300/HLA-DQB1/HLA-F/ICAM1/NFKB2/MAD1L1/SMAD3/HLA-DRA/IL1R1/IL1R2/STAT5B/PTEN/E2F3/HLA-DMB/HLA-E/HLA-DMA/ADCY3/ATF4/HLA-DPA1/MAPK1/KRAS/HLA-DOA/CREB5/TLN1/IL2RG/SPI1/TNF/NFATC1/STAT5A/MAPK8/RELA/KAT2B/PPP3R1/AKT3/ZFP36/HLA-C/IL6/HLA-DQB2/CANX/TGFBR1/NRAS/ITGB2/PPP3CA/ATF2/CHUK/MAP2K4/PTTG1/PIK3CD/PPP3CC/CCND3/POLB/JAK3/CRTC2/CSF2/XIAP/IKBKG	5.97428105381303
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	51/1711	133/9376	2.10129063160531	SOD2/CDKN1A/FOXO3/BRAF/BCL6/IRS2/MAP2K1/SGK1/GABARAPL1/GRB2/PIK3R1/TGFB1/CREBBP/PIK3CB/PLK3/EP300/IL10/RAF1/SMAD3/PRKAG2/BCL2L11/FOXO1/HOMER1/STAT3/GADD45B/MAPK13/PTEN/SOS2/MAPK1/PLK2/MAPK14/KRAS/PDPK1/STK4/SIRT1/GADD45A/MAPK8/USP7/AKT3/CDKN1B/IL6/ATG12/MDM2/TGFBR1/FBXO32/NRAS/CHUK/IGF1R/PIK3CD/ARAF/INSR	6.04332363122728
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	35/1711	77/9376	2.49083470591361	NFKBIA/NFKB1/GAB2/CDKN1A/BRAF/MAP2K1/GRB2/PIK3R1/TGFB1/PIK3CB/RAF1/SMAD3/GADD45B/STAT5B/RUNX1/E2F3/CBL/SOS2/MAPK1/KRAS/CRK/CTBP2/GADD45A/STAT5A/RELA/AKT3/CDKN1B/MDM2/TGFBR1/PTPN11/NRAS/CHUK/PIK3CD/ARAF/IKBKG	6.20599321551822
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	101/1711	333/9376	1.66205246742944	NFKB1/PTGS2/VEGFA/CDKN1A/ITGA5/HLA-B/TRAF3/HLA-A/MX1/ITGAV/JAK1/ATP6V1H/MAP2K1/MX2/TBK1/GRB2/PIK3R1/EIF2AK2/STAT1/CREBBP/PSEN1/PIK3CB/EP300/PPP2R2A/CSNK1A1/NOTCH2/HLA-F/ATP6V0D1/PPP2CA/RAF1/PKM/TICAM1/PTGER4/ITGB8/OASL/FOXO1/IRF1/UBR4/RHEB/LAMB3/ATP6V1B2/MAML3/CHD4/PTEN/HLA-E/SOS2/MAPK1/IFNAR2/PPP2R2D/KRAS/CREB5/NOTCH1/ISG15/TCIRG1/TNF/LFNG/IFNAR1/PPP2R5C/TCF7L2/ATP6V1E1/RELA/GSK3B/MAML1/UBE3A/ITGA4/AKT3/TYK2/ATP6V1F/IRF9/ATP6V1A/STAT2/ATP6V1C1/HLA-C/CDKN1B/PPP2R5A/HES1/HES4/MDM2/PPP2R3C/ATP6V1D/TCF7/NRAS/ATP6V0B/CDC42/WNT2B/CHUK/CTNNB1/AXIN1/IKBKE/PIK3CD/THBS1/ITGB1/MAML2/CCND3/ATP6V0C/CASP8/CASP3/NFX1/IKBKG/PRKCI/FAS	5.81182894009731
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	40/1711	94/9376	2.33184525659997	CXCL8/NFKBIA/TNFAIP3/NFKB1/PTGS2/CXCL2/MAPK6/TRAF3/CXCL3/TAB2/CCL20/TBK1/IL1B/FOSL1/MMP9/LCN2/MAPK13/CXCL1/MAPK1/MAPK14/CEBPB/TNF/MAPK8/RELA/GSK3B/CSF3/IL6/USP25/S100A9/IL17RA/CHUK/IKBKE/TAB3/TRAF6/TRAF3IP2/CASP8/CASP3/CSF2/IKBKG/FOSB	6.1312846126049
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	41/1711	98/9376	2.29258459666742	GAB2/SPHK1/PAK1/MAP2K1/PIK3R1/LIMK2/ACTR3/LYN/PLCG2/VAV1/PIK3CB/DNM2/VASP/PLA2G6/HCK/RAF1/PRKCB/PRKCE/PTPRC/MAPK1/ASAP1/MARCKSL1/CRK/FCGR3B/SYK/FCGR2B/AKT3/INPP5D/PLA2G4A/PIP5K1A/PRKCD/RAC2/ACTR2/NCF1/VAV2/CDC42/PIK3CD/RAC1/VAV3/ARPC2/ARPC5	6.07714212728246
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	32/1711	68/9376	2.5787465190635	BCL2A1/NFKB1/BRAF/PPARD/MAP2K1/GRB2/PIK3R1/PIK3CB/RARA/RAF1/STAT3/STAT5B/RUNX1/SOS2/MAPK1/KRAS/SPI1/STAT5A/TCF7L2/RELA/AKT3/TCF7/NRAS/CHUK/PML/PIK3CD/ZBTB16/ARAF/ITGAM/MPO/CSF2/IKBKG	6.17295681068903
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	57/1711	157/9376	1.98949472688896	CXCL8/NFKB1/MAP2K3/CDKN1A/RASSF5/FOXO3/MAPKAPK2/HLA-B/HLA-A/SQSTM1/MAP2K1/PIK3R1/IL1A/TGFB1/PIK3CB/HIPK2/HLA-F/NBN/RAF1/SMAD3/MRAS/FOXO1/RHEB/CAPN2/GADD45B/MAPK13/PTEN/E2F3/HLA-E/MAPK1/LIN54/MCU/MAPK14/KRAS/ITPR1/HUS1/SIRT1/NFATC1/FBXW11/GADD45A/RELA/PPP3R1/AKT3/PPID/PPP1CB/HLA-C/IL6/MDM2/TGFBR1/NRAS/PPP3CA/TRPM7/PIK3CD/PPP3CC/TRAF3IP2/CCND3/HIPK3	5.90712235084487
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	68/1711	200/9376	1.86314436002338	CXCL8/NFKBIA/NFKB1/TAB2/PAK1/GNA13/MYH9/ACTR3/CYTH1/RAB1A/ARHGEF2/ABI1/IL1B/GNA12/SEC24A/IL18/IRAK1/SRC/IL1R1/TUBA1C/MAPK13/TUBB4B/MYD88/ROCK1/TUBA4A/MAPK1/EZR/HCLS1/MAPK14/RIPK1/TNFRSF10B/SEC24D/WIPF1/MYO1F/CYFIP2/TNF/MYO1G/WIPF2/NLRP3/MAPK8/RELA/TUBB6/CYCS/NFKBIB/GAPDH/RHOA/IL6/TNFRSF10A/ACTR2/PTPN11/SEC24C/ARF1/CDC42/CHUK/CYTH3/TAB3/TRAF6/ITGB1/RAC1/CASP9/CASP8/CASP3/SEC24B/TLR4/IKBKG/ARPC2/FAS/ARPC5	5.82943274119507
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	48/1711	125/9376	2.10425715955582	NFKB1/GAB2/SPHK1/MAP2K1/GNA13/BID/PIK3R1/NSMAF/PIK3CB/GNA12/PPP2R2A/BCL2/PPP2CA/RAF1/PRKCB/PRKCE/SGMS2/MAPK13/PTEN/SGPP2/ROCK1/MAPK1/GNAI3/CTSD/PPP2R2D/MAPK14/KRAS/PDPK1/ASAH1/TNF/PPP2R5C/GNAQ/MAPK8/RELA/ABCC1/SGPL1/AKT3/RAC2/RHOA/PPP2R5A/PPP2R3C/PLCB2/S1PR3/NRAS/CERS6/PIK3CD/RAC1/MAP3K5	5.87199197166553
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	36/1711	83/9376	2.37679649046214	JARID2/RYBP/EZH2/CREBBP/FOXK2/TFDP1/EP300/UBE2D1/UBE2D3/LCOR/PHF19/PCGF5/YAF2/PHC2/ASXL1/SFMBT2/CBX3/MAX/KDM2A/USP7/USP16/FBRS/L3MBTL4/CBX4/BCOR/FBRSL1/ASXL2/RNF2/SCML1/AEBP2/TEX10/OGT/E2F6/MBD6/MTF2/PHF1	5.95230794158416
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	50/1711	133/9376	2.06008885451501	PTK2B/LCP2/HLA-B/HLA-A/BRAF/PAK1/MAP2K1/BID/GRB2/PIK3R1/PLCG2/VAV1/PIK3CB/ICAM1/IFNGR2/RAF1/PRKCB/IFNGR1/HLA-E/SOS2/MAPK1/IFNAR2/KRAS/TNFRSF10B/FCGR3B/TNF/NFATC1/IFNAR1/SYK/PPP3R1/RAC2/HLA-C/CD48/SH3BP2/LAT2/TNFRSF10A/PTPN11/NRAS/ITGB2/VAV2/KLRD1/PPP3CA/PIK3CD/ARAF/RAC1/PPP3CC/CASP3/CSF2/VAV3/FAS	5.81722920529412
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	38/1711	90/9376	2.31370868238197	NFKBIA/NFKB1/MAP2K3/HIF1A/JAK1/MAP2K1/TLR2/PIK3R1/STAT1/PIK3CB/IFNGR2/RAF1/TICAM1/EML4/NFKBIE/STAT3/IFNGR1/MAPK13/PTEN/MYD88/MAPK1/MAPK14/KRAS/NFATC1/RELA/NFKBIB/PPP3R1/AKT3/PTPN11/NRAS/PPP3CA/CHUK/PIK3CD/CD274/TRAF6/PPP3CC/TLR4/IKBKG	5.91644114485711
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	32/1711	70/9376	2.50506804709026	VEGFA/CDKN1A/HIF1A/RAPGEF1/BRAF/PAK1/MAP2K1/GRB2/PIK3R1/TGFB1/CREBBP/PIK3CB/EP300/RAF1/SOS2/MAPK1/KRAS/CRK/RAP1A/TFE3/RAP1B/ELOC/VHL/AKT3/EGLN1/PTPN11/NRAS/CDC42/PIK3CD/ARAF/RAC1/MET	5.97142792801677
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	32/1711	70/9376	2.50506804709026	HLA-DRB5/HLA-B/HLA-A/CD55/HLA-DQA1/BID/HLA-DPB1/HLA-DRB1/HLA-DQA2/HLA-DQB1/HLA-F/ABL2/ICAM1/HLA-DRA/HLA-DMB/HLA-E/HLA-DMA/HLA-DPA1/CD80/HLA-DOA/EIF4G2/CYCS/SNTB1/RAC2/HLA-C/HLA-DQB2/EIF4G3/ITGB2/RAC1/CASP9/CASP8/CASP3	5.97142792801677
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	24/1711	45/9376	2.92257938827197	HLA-DRB5/HLA-B/HLA-A/HLA-DQA1/HLA-DPB1/IL1A/HLA-DRB1/IL1B/HLA-DQA2/HLA-DQB1/HLA-F/HLA-DRA/HLA-DMB/HLA-E/HLA-DMA/HLA-DPA1/CD80/HLA-DOA/TNF/HLA-C/IL6/HLA-DQB2/KLRD1/FAS	6.10774655660183
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	34/1711	77/9376	2.41966800003036	NFKB1/VEGFA/CDKN1A/BRAF/RALGDS/JAK1/MAP2K1/PIK3R1/STAT1/TGFB1/PIK3CB/RALA/RAF1/SMAD3/STAT3/GADD45B/E2F3/MAPK1/KRAS/BRCA2/GADD45A/MAPK8/RELA/AKT3/RAC2/TGFBR1/CDC42/CHUK/PIK3CD/RALB/ARAF/RAC1/CASP9/IKBKG	5.90974300606825
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	35/1711	82/9376	2.33895454091888	HLA-DRB5/HLA-B/HLA-A/HLA-DQA1/IFI30/HLA-DPB1/HLA-DRB1/HLA-DQA2/HLA-DQB1/CIITA/HLA-F/HLA-DRA/CD74/HLA-DMB/HLA-E/HLA-DMA/HLA-DPA1/TAP1/HSPA5/HLA-DOA/HSPA6/TAPBP/TNF/CTSS/HLA-C/TAP2/HLA-DQB2/CANX/NFYC/PSME1/PSME2/HSPA8/KLRD1/RFX5/PDIA3	5.75341879768896
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	40/1711	101/9376	2.17023221901384	CXCL8/NFKB1/VEGFA/THBD/PIK3R1/STAT1/IL1A/TGFB1/PLCG2/PIK3CB/IL1B/BCL2/ICAM1/DIAPH1/SMAD3/FOXO1/STAT3/PRKCB/PRKCE/MAPK13/STAT5B/MAPK1/MAPK14/KRAS/TNF/NFATC1/STAT5A/MAPK8/RELA/AKT3/PRKCD/CDKN1B/IL6/PLCB2/TGFBR1/NRAS/CDC42/PIK3CD/RAC1/CASP3	5.586378301072
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	55/1711	158/9376	1.90753797098447	FNIP2/SLC7A5/EIF4E/BRAF/TBC1D7/FNIP1/ATP6V1H/MAP2K1/SGK1/GRB2/PIK3R1/PIK3CB/SLC3A2/RAF1/SESN2/RHEB/ATP6V1B2/PRKCB/RPS6KA3/RPTOR/MAPKAP1/PTEN/RRAGD/SOS2/MAPK1/CLIP1/KRAS/LAMTOR3/DDIT4/LPIN2/PDPK1/TNF/RRAGC/ATP6V1E1/LPIN1/GSK3B/CAB39/SEC13/RPS6KA1/AKT3/ATP6V1F/ATP6V1A/ATP6V1C1/RHOA/ATP6V1D/RICTOR/NRAS/WNT2B/WDR59/CHUK/IGF1R/PIK3CD/CAB39L/STRADA/INSR	5.43537559103927
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	41/1711	106/9376	2.11955934408875	NFKBIA/NFKB1/CDKN1A/BRAF/MAP2K1/GRB2/PIK3R1/CREBBP/PIK3CB/EP300/BCL2/RAF1/PLAU/MMP9/FOXO1/IL1R2/PTEN/E2F3/ATF4/SOS2/MAPK1/KRAS/CREB5/PDPK1/TCF7L2/RELA/GSK3B/AKT3/CDKN1B/ZEB1/MDM2/TCF7/NRAS/CHUK/CTNNB1/IGF1R/SLC19A1/PIK3CD/ARAF/CASP9/IKBKG	5.476646984754
Human Diseases	Immune disease	hsa05330	Allograft rejection	21/1711	39/9376	2.9506811131592	HLA-DRB5/HLA-B/HLA-A/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DQA2/HLA-DQB1/HLA-F/IL10/HLA-DRA/HLA-DMB/HLA-E/HLA-DMA/HLA-DPA1/CD80/HLA-DOA/TNF/HLA-C/HLA-DQB2/FAS	5.76725914764064
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	22/1711	42/9376	2.87039047062425	SAT1/FTH1/ACSL1/ACSL5/ACSL3/MAP1LC3B/SLC7A11/SLC39A8/SLC3A2/ACSL4/ATG7/PRNP/GCLC/SLC11A2/PCBP1/HMOX1/TFRC/TF/LPCAT3/MAP1LC3A/MAP1LC3B2/GCLM	5.73954666786602
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	31/1711	72/9376	2.35937398532372	CXCL8/NFKBIA/NFKB1/TRAF3/IFIH1/TBK1/CYLD/TRIM25/ZNFX1/TANK/ADAR/IRF7/MAPK13/AZI2/MAPK14/RIPK1/DDX3X/ISG15/TNF/MAPK8/RELA/NFKBIB/ATG12/CASP10/OTUD5/CHUK/IKBKE/TRAF6/CASP8/TKFC/IKBKG	5.47047345748626
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	50/1711	142/9376	1.92951984260913	UBE2R2/UBE2H/UBE2E1/UBR5/BIRC2/PIAS1/UBE2D1/UBE2D3/FBXW7/CUL3/UBC/CUL1/UBE2S/SMURF1/SIAH1/UBE2L6/UBE2N/COP1/TRIP12/CBL/UBE2G1/BIRC3/UBE2Z/SMURF2/RNF7/CUL4A/FBXW11/SAE1/UBA1/WWP2/UBE2J1/ELOC/VHL/BIRC6/UBE3A/UBE2Q2/SOCS1/UBE2B/MGRN1/UBE2O/MDM2/UBA6/FZR1/PML/ERCC8/UBE4A/TRAF6/RCHY1/XIAP/UBE2W	5.27305699615895
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	31/1711	73/9376	2.32705379374395	CDKN1A/RASSF5/FOXO3/BRAF/MAP2K1/GRB2/PIK3R1/PLCG2/PIK3CB/RAF1/EML4/STAT3/PRKCB/GADD45B/STAT5B/E2F3/SOS2/MAPK1/KRAS/RXRA/PDPK1/STK4/GADD45A/STAT5A/AKT3/NRAS/PIK3CD/ARAF/CASP9/JAK3/MET	5.37765591552632
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	27/1711	60/9376	2.46592635885447	PTGS2/VEGFA/MAPKAPK2/SPHK1/MAP2K1/PIK3R1/PLCG2/PIK3CB/SRC/RAF1/PRKCB/MAPK13/MAPK1/MAPK14/KRAS/PPP3R1/AKT3/PLA2G4A/RAC2/MAPKAPK3/NRAS/CDC42/PPP3CA/PIK3CD/RAC1/CASP9/PPP3CC	5.38180059798061
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	22/1711	44/9376	2.73991817650497	HLA-DRB5/HLA-B/HLA-A/HLA-DQA1/HLA-DPB1/IL1A/HLA-DRB1/IL1B/HLA-DQA2/HLA-DQB1/HLA-F/HLA-DRA/HLA-DMB/HLA-E/HLA-DMA/HLA-DPA1/CD80/HLA-DOA/TNF/HLA-C/HLA-DQB2/FAS	5.46540514965433
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	44/1711	122/9376	1.97633442239703	HIF1A/ITGAV/MAP2K1/PIK3R1/STAT1/MED13/PLCG2/CREBBP/PIK3CB/SLC9A1/EP300/NOTCH2/SRC/RAF1/ATP2A2/FOXO1/RHEB/PRKCB/MED13L/ATP1B3/ATP2A3/MAPK1/ATP1A1/KRAS/RXRA/SIN3A/PDPK1/NOTCH1/GSK3B/KAT2B/AKT3/NCOA3/MDM2/PLCB2/MED14/MED1/NRAS/PFKP/MED17/CTNNB1/PIK3CD/CASP9/MED12L/PFKFB2	5.1282398902053
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	39/1711	105/9376	2.03536778826083	RAB7A/RABGEF1/HIF1A/FOXO3/EIF2AK3/SQSTM1/GABARAPL1/TBK1/MAP1LC3B/ARIH1/RAB5A/SRC/USP15/MRAS/UBC/SMURF1/SIAH1/ATF4/TBC1D15/TAX1BP1/KRAS/SMURF2/TFE3/MAPK8/BNIP3L/RELA/TOMM40L/USP8/BECN1/BCL2L13/RAB7B/MFN2/MFN1/RHOT1/NRAS/TFEB/MAP1LC3A/CALCOCO2/MAP1LC3B2	5.04058069425052
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	47/1711	138/9376	1.86632107674976	RAPGEF1/EIF4E/BRAF/INPP5A/IRS2/MAP2K1/GRB2/PIK3R1/PIK3CB/PTPN1/FLOT1/HK2/RAF1/PRKAG2/FOXO1/RHEB/RHOQ/RPTOR/CBL/SOS2/MAPK1/KRAS/CRK/PDPK1/FBP1/HK1/PPP1R3B/MAPK8/GSK3B/AKT3/MKNK2/SOCS4/SOCS1/PPP1CB/SH2B2/PDE3B/SREBF1/GYS1/NRAS/FLOT2/PIK3CD/ARAF/PYGM/PRKCI/INSR/PHKA2/SORBS1	4.84377552137038
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	37/1711	100/9376	2.02753945061368	CD44/ITGA5/HLA-DRB5/IL6R/IL3RA/CD55/HLA-DQA1/ANPEP/HLA-DPB1/IL1A/HLA-DRB1/IL1B/HLA-DQA2/CSF2RA/HLA-DQB1/CSF3R/IL4R/CD22/HLA-DRA/IL1R1/IL1R2/HLA-DMB/HLA-DMA/HLA-DPA1/HLA-DOA/TNF/ITGA4/CD38/CSF3/IL6/HLA-DQB2/CD37/TFRC/CD24/ITGAM/MME/CSF2	4.8805941862372
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	42/1711	122/9376	1.8865010395608	FOXO3/PFKFB3/IRS2/PIK3R1/PIK3CB/ADIPOR2/CAMKK2/PPP2R2A/PPP2CA/PRKAG2/FOXO1/RHEB/RPTOR/PPARG/PPP2R2D/RAB8A/CREB5/PDPK1/FBP1/CPT1A/RAB2A/SIRT1/RAB10/TBC1D1/PPP2R5C/CAB39/AKT3/PPP2R5A/PPP2R3C/SREBF1/GYS1/PFKP/PFKFB4/IGF1R/HMGCR/PIK3CD/CAB39L/CRTC2/STRADA/INSR/PFKFB2/SCD	4.65638605942283
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	25/1711	59/9376	2.32196455636014	CDKN1A/FOXO3/BRAF/MAP2K1/GRB2/PIK3R1/PIK3CB/RAF1/GADD45B/PTEN/SOS2/MAPK1/KRAS/PDPK1/GADD45A/TCF7L2/GSK3B/AKT3/TCF7/NRAS/CTNNB1/AXIN1/PIK3CD/ARAF/CASP9	4.8124068105748
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	61/1711	201/9376	1.66303491310252	CXCL8/BCL2A1/NFKB1/CDK14/CDKN1A/BCL6/TRAF1/DOT1L/REL/KDM6A/BIRC2/NR4A3/RARA/ETV6/ID2/DDIT3/DDX5/PLAU/MMP9/JMJD1C/FOXO1/FUS/GADD45B/IL1R2/RUNX1/PBX3/EWSR1/PPARG/NFKBIZ/RXRA/BIRC3/SIN3A/ZBTB17/TFE3/SPI1/CEBPB/RUNX2/ATF1/GADD45A/RELA/MAX/CCNT2/CCNT1/CDKN1B/AFF1/ZEB1/IL6/MDM2/SS18L1/PML/IGF1R/DEFA4/ZBTB16/HMGA2/ITGAM/MPO/DEFA3/CSF2/ETV7/LDB1/MET	4.48937571619346
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	34/1711	93/9376	2.0033810322832	NFKBIA/NFKB1/PTGS2/CDKN1A/TRAF3/ITGAV/TRAF1/PIK3R1/BIRC2/PIK3CB/BCL2/CKS2/LAMB3/GADD45B/PTEN/E2F3/RXRA/BIRC3/ZBTB17/GADD45A/RELA/MAX/CYCS/AKT3/CDKN1B/CHUK/PIK3CD/TRAF6/ITGB1/CASP9/CASP3/XIAP/IKBKG/APAF1	4.59428306236329
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	30/1711	80/9376	2.05493863237873	VEGFA/FOXO3/EIF4E/IL6R/BRAF/JAK1/MAP2K1/GRB2/PIK3R1/PLCG2/PIK3CB/BCL2/SRC/RAF1/BCL2L11/AXL/STAT3/PRKCB/PTEN/SOS2/MAPK1/KRAS/GSK3B/AKT3/IL6/NRAS/IGF1R/PIK3CD/ARAF/MET	4.47691342514609
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	52/1711	168/9376	1.69613982355069	TNFAIP3/FTH1/CHMP4B/CFLAR/JAK1/SQSTM1/BID/EIF2AK2/STAT1/CYLD/IL1A/BIRC2/IL1B/GLUL/CHMP1B/STAT4/BCL2/IFNGR2/TICAM1/STAT3/CAPN2/IFNGR1/STAT5B/IFNAR2/CHMP2B/VPS4B/RIPK1/BIRC3/TNFRSF10B/TNF/IFNAR1/NLRP3/STAT5A/MAPK8/TYK2/IRF9/PLA2G4A/STAT2/PPID/STAT6/GLUD1/DNM1L/TNFRSF10A/TRPM7/AIFM1/MLKL/CASP8/JAK3/PYGM/XIAP/TLR4/FAS	4.30153070944519
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	52/1711	168/9376	1.69613982355069	CDKN1A/IL6R/IL3RA/JAK1/GRB2/PIK3R1/STAT1/CREBBP/PIK3CB/MCL1/EP300/CSF2RA/STAT4/BCL2/OSM/PIAS1/CSF3R/IL10/IL4R/IFNGR2/RAF1/STAT3/IFNGR1/STAT5B/SOS2/IL10RA/IFNAR2/IL13RA1/IL2RG/IFNAR1/STAT5A/IL10RB/STAM/AKT3/CLCF1/TYK2/PTPN2/IRF9/SOCS4/STAT2/SOCS1/STAT6/CSF3/IL6/IL19/PTPN11/CRLF2/CSF2RB/PIK3CD/CCND3/JAK3/CSF2	4.30153070944519
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	21/1711	50/9376	2.30153126826417	HLA-DRB5/CXCR4/HLA-DQA1/HLA-DPB1/TGFB1/HLA-DRB1/HLA-DQA2/HLA-DQB1/IL10/HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/CD80/HLA-DOA/TNFSF13B/ITGA4/TNFSF13/IL6/HLA-DQB2/ICOSLG	4.35959821545586
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	35/1711	103/9376	1.86208031412959	CXCL8/RAB7A/NFKB1/CXCL2/CXCL3/TLR2/PIK3R1/TGFB1/PIK3CB/ACTN1/IL1B/RAB5A/IL10/SERPINB9/IL1R1/LAMB3/PRKCB/GNA15/IL1R2/CXCL1/GNAL/SERPINB10/TNF/ARG1/GNAQ/RELA/IL6/RAB7B/PLCB2/ITGB2/PIK3CD/ITGAM/CASP3/CSF2/TLR4	4.15633719567526
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	59/1711	203/9376	1.59266179718023	VEGFA/ITGA5/RAPGEF1/BRAF/ITGAV/PAK1/MAP2K1/GRB2/PIK3R1/VAV1/BIRC2/PIK3CB/ACTN1/VASP/BCL2/DIAPH1/SRC/RAF1/PPP1R12A/ITGB8/LAMB3/CAPN2/PRKCB/PTEN/ROCK1/SOS2/MAPK1/ZYX/CRK/BIRC3/RAP1A/TLN1/PDPK1/FLNA/RAP1B/PARVB/MAPK8/GSK3B/ITGA4/AKT3/PIP5K1A/PARVG/PPP1CB/RAC2/RHOA/PPP1R12C/VAV2/CDC42/CTNNB1/IGF1R/PIK3CD/THBS1/ITGB1/RAC1/CCND3/PPP1R12B/XIAP/VAV3/MET	4.03323771100003
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	61/1711	212/9376	1.57674536572456	DOCK4/SIPA1L1/MAP2K3/LCP2/VEGFA/RASSF5/RAPGEF1/BRAF/RALGDS/MAP2K1/PIK3R1/FPR1/VAV1/PIK3CB/RASGRP3/VASP/RALA/SRC/RAF1/RAPGEF2/MRAS/PRKCB/MAPK13/ADORA2A/ADCY3/MAPK1/GNAI3/MAPK14/KRAS/APBB1IP/CRK/RAP1A/TLN1/RAPGEF6/RAP1B/GNAQ/SIPA1L2/AKT3/ADORA2B/RAC2/RHOA/FYB1/PRKD3/PLCB2/NRAS/ITGB2/VAV2/CDC42/CTNNB1/IGF1R/PIK3CD/RALB/THBS1/ITGAM/ITGB1/RAC1/VAV3/RASGRP2/PRKCI/INSR/MET	4.0129529432832
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	27/1711	73/9376	2.02678878809956	ELL2/CHMP4B/CXCR4/MX1/MX2/RANBP2/AFF4/CREBBP/ELL/EP300/APOBEC3A/PDCD6IP/SUPT5H/TNPO3/NUP153/VPS4B/SERINC3/CCNT2/KAT2B/TSG101/CCR5/CCNT1/CPSF6/HGS/SAMHD1/CPSF7/SERINC5	4.16088392674845
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	28/1711	78/9376	1.96712074210613	BTG1/PABPC4/BTG3/TENT4A/PABPC1/DCP1A/HSPA9/PATL1/CNOT2/CNOT1/DCP2/DDX6/TOB1/CNOT4/TENT4B/TOB2/ENO1/PNPT1/DHX36/CNOT6L/CNOT6/XRN2/PFKP/BTG2/ENO3/PAN3/ZCCHC7/PAN2	4.05217125650813
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	28/1711	78/9376	1.96712074210613	CXCL8/NFKB1/ITGA5/C3/IL1A/IL1B/IL10/IRAK1/TICAM1/IRF1/MAPK13/MYD88/MAPK1/GNAI3/MAPK14/TNF/NLRP3/MAPK8/RELA/IRF8/RHOA/IL6/ITGB2/TRAF6/ITGAM/ITGB1/CASP3/TLR4	4.05217125650813
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	30/1711	86/9376	1.91157082081742	CDKN1A/EREG/BRAF/PAK1/MAP2K1/GRB2/PIK3R1/HBEGF/PLCG2/PIK3CB/ABL2/SRC/RAF1/PRKCB/STAT5B/CBL/SOS2/MAPK1/KRAS/CRK/AREG/STAT5A/MAPK8/GSK3B/AKT3/CDKN1B/NRAS/MAP2K4/PIK3CD/ARAF	4.01223486115355
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	26/1711	71/9376	2.0067006363135	NFKB1/FOXO3/MAP2K1/GRB2/PIK3R1/STAT1/PIK3CB/SRC/RAF1/IRF1/STAT3/MAPK13/STAT5B/SOS2/MAPK1/MAPK14/KRAS/STAT5A/MAPK8/RELA/GSK3B/AKT3/SOCS4/SOCS1/NRAS/PIK3CD	4.02277638598531
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	15/1711	32/9376	2.56867329047341	BID/BIRC2/PMAIP1/BCL2/BCL2L11/BIRC3/MAPK8/BIRC6/CYCS/BECN1/CASP9/CASP8/CASP3/XIAP/APAF1	4.19948118289794
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	27/1711	75/9376	1.97274108708358	CDKN1A/BID/PIK3R1/BIRC2/PIK3CB/PMAIP1/BCL2/REV3L/GSTO1/ERCC1/MAPK1/BIRC3/PDPK1/TOP2B/CYCS/AKT3/GSTO2/MDM2/SLC31A1/PIK3CD/CASP9/CASP8/CASP3/XIAP/MAP3K5/APAF1/FAS	3.99592780418657
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	37/1711	116/9376	1.74787883673593	PTK2B/RASSF5/CXCR4/PIK3R1/PLCG2/VAV1/PIK3CB/ACTN1/VASP/NCF2/RHOH/ICAM1/MMP9/PRKCB/MAPK13/ROCK1/EZR/GNAI3/MAPK14/RAP1A/RAP1B/MSN/ITGA4/RAC2/RHOA/NCF1/PTPN11/ITGB2/VAV2/CDC42/CTNNB1/PIK3CD/ITGAM/ITGB1/RAC1/F11R/VAV3	3.82921109418023
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	21/1711	54/9376	2.13104747061498	HLA-DRB5/HLA-B/HLA-A/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DQA2/HLA-DQB1/HLA-F/IL10/HLA-DRA/HLA-DMB/HLA-E/HLA-DMA/HLA-DPA1/CD80/HLA-DOA/HLA-C/HLA-DQB2/TG/FAS	3.93801827163259
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	35/1711	109/9376	1.75958048032429	NFKBIA/NFKB1/IRS2/PIK3R1/PIK3CB/PTPN1/PRKAG2/FOXO1/STAT3/PRKCB/PRKCE/RPS6KA3/PTEN/CREB5/PDPK1/CPT1A/TNF/PPP1R3B/MAPK8/RELA/GSK3B/RPS6KA1/AKT3/PRKCD/PPP1CB/IL6/SREBF1/GYS1/PTPN11/OGT/PIK3CD/PYGM/CRTC2/GFPT1/INSR	3.76853043094641
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	23/1711	62/9376	2.03284251805207	NCOR2/NUMB/CREBBP/PSEN1/ATXN1/EP300/NOTCH2/ADAM17/TLE3/MAML3/SPEN/TLE4/CTBP2/NOTCH1/NRARP/LFNG/DTX3L/MAML1/KAT2B/SNW1/HES1/APH1B/MAML2	3.85492913766097
Organismal Systems	Immune system	hsa04611	Platelet activation	39/1711	126/9376	1.69613982355069	PIK3R5/LCP2/GNA13/PIK3R1/LYN/PLCG2/PIK3CB/VASP/SRC/PPP1R12A/MAPK13/ROCK1/PIK3CG/ADCY3/MAPK1/GNAI3/MAPK14/APBB1IP/STIM1/RAP1A/TLN1/ITPR1/BTK/RAP1B/FERMT3/SYK/P2RX1/GNAQ/PIK3R6/AKT3/PLA2G4A/PPP1CB/RHOA/PLCB2/PIK3CD/ITGB1/TBXAS1/RASGRP2/PRKCI	3.71676795754033
NA	NA	hsa04517	IgSF CAM signaling	78/1711	299/9376	1.42952252687216	ITGAX/LCP2/ITGA5/MBP/PAK1/MAP2K1/MYH9/GRB2/PIK3R1/ACTR3/LYN/PLCG2/VAV1/PIK3CB/ACTN1/PPFIA1/NPHS1/TJP2/SLAMF7/ICAM1/SRC/RAPGEF2/FOXO1/TUBA1C/PRKCB/MAPK13/EPB41L3/TUBB4B/CD84/TUBA4A/TRIO/MAPK1/EZR/CD80/MAPK14/RAP1A/PDPK1/RAPGEF6/IQGAP1/RAP1B/IL1RAP/MSN/ERC1/APP/MAPK8/GSK3B/TUBB6/ITGA4/AKT3/INPP5D/RDX/RHOA/CD48/CD226/ACTR2/PTPN11/ITGB2/VAV2/CDC42/CTNNB1/SRGAP1/PIK3CD/CADM1/TRAF6/ITGAM/ITGB1/CRTAM/RAC1/F11R/CADM4/VAV3/JAML/PRKCI/KIRREL2/ARPC2/ICAM3/ARPC5/SORBS1	3.56619375971
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	27/1711	78/9376	1.89686642988805	INPP5A/SYNJ2/PLCG2/PIK3CB/MTMR3/PTEN/PIK3CG/SYNJ1/IPMK/ITPK1/PI4K2A/PI4KB/PI4K2B/INPP5D/MTMR6/ITPKB/PIP5K1A/IP6K1/INPP4A/PIP4K2A/ITPKC/PLCB2/INPP5K/MTMR14/IP6K2/PIK3CD/IPPK	3.75781038488018
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	17/1711	41/9376	2.27212726832119	CXCL8/VEGFA/CDKN1A/BRAF/MAP2K1/HBEGF/SRC/RAF1/MMP9/E2F3/MAPK1/KRAS/TYMP/MDM2/NRAS/THBS1/ARAF	3.85673582952162
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	26/1711	75/9376	1.89967660237678	CDKN1A/BID/PMAIP1/BCL2/CD82/SESN2/ZNF385A/GADD45B/SIAH1/PTEN/COP1/TNFRSF10B/GADD45A/CYCS/MDM2/TNFRSF10A/PPM1D/THBS1/MDM4/CASP9/CCND3/RCHY1/CASP8/CASP3/APAF1/FAS	3.69578585499246
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	42/1711	142/9376	1.62079666779167	NFKB1/VEGFA/NFE2L2/ITGAV/SQSTM1/THBD/PIK3R1/ARHGEF2/IL1A/PIK3CB/IL1B/NCF2/BCL2/ICAM1/SRC/MMP9/IL1R1/IL1R2/MAPK13/GSTO1/TXN/SDC4/MAPK14/TNF/MAPK8/RELA/AKT3/DUSP1/SDC2/HMOX1/RAC2/RHOA/GSTO2/ACVR1/NCF1/CHUK/CTNNB1/MAP2K4/PIK3CD/RAC1/IKBKG/MAP3K5	3.52170665136361
Human Diseases	Immune disease	hsa05310	Asthma	14/1711	32/9376	2.39742840444185	HLA-DRB5/HLA-DQA1/HLA-DPB1/HLA-DRB1/HLA-DQA2/HLA-DQB1/IL10/HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/HLA-DOA/TNF/HLA-DQB2	3.74104303588263
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	37/1711	122/9376	1.66191758247023	MAP2K3/IRS2/MAP2K1/GRB2/PIK3R1/STAT1/PLCG2/CREBBP/PIK3CB/EP300/RAF1/STAT3/PRKCB/MAPK13/STAT5B/ADCY3/ATF4/SOS2/MAPK1/GNAI3/MAPK14/KRAS/CRK/CREB5/ITPR1/GNAQ/STAT5A/MAPK8/GSK3B/AKT3/SOCS1/PLCB2/NRAS/ATF2/MAP2K4/PIK3CD/SSTR2	3.47675148246664
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	29/1711	90/9376	1.76572504708098	SOD2/NFKB1/FOXO3/EIF4E/IRS2/PIK3R1/RB1CC1/PIK3CB/ADIPOR2/CAMKK2/SESN2/PRKAG2/FOXO1/RHEB/RPTOR/ADCY3/PPARG/ATF4/KRAS/CREB5/SIRT1/RELA/AKT3/NRAS/ATF2/IGF1R/PIK3CD/ATG13/INSR	3.44853256658336
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	33/1711	108/9376	1.67439444119748	RANBP2/NUP98/KPNA4/NXF1/IPO7/TNPO3/NUP58/NUP153/XPO6/AHCTF1/KPNA1/KPNB1/IPO5/EIF4A3/RBM8A/KPNA2/SEC13/NUP62/KPNA3/NXT1/SENP2/POM121C/POM121/NUP93/IPO11/NUP188/KPNA6/NUP210L/NUP88/NUP50/UPF3B/NXT2/CASC3	3.3303310803551
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	61/1711	232/9376	1.44081904109313	ITGAX/ITGA5/CXCR4/BRAF/ITGAV/RGCC/PAK1/MAP2K1/GNA13/MYH9/PIK3R1/LIMK2/ACTR3/VAV1/SSH1/PIK3CB/ACTN1/SLC9A1/GNA12/DIAPH1/SRC/RAF1/PPP1R12A/MRAS/ITGB8/SPATA13/ROCK1/SOS2/MAPK1/EZR/KRAS/CRK/IQGAP1/CYFIP2/MSN/ITGAD/SSH2/ITGA4/AKT3/PIP5K1A/PPP1CB/RAC2/ARHGEF7/RDX/RHOA/PIP4K2A/PPP1R12C/ACTR2/NRAS/ITGB2/VAV2/CDC42/PIK3CD/ARAF/ITGAM/ITGB1/RAC1/PPP1R12B/VAV3/ARPC2/ARPC5	3.21211283414449
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	42/1711	149/9376	1.54465185789542	CXCL8/PIK3R5/GAB2/PTK2B/RALGDS/SPHK1/MAP2K1/GNA13/GRB2/PIK3R1/CYTH1/PLCG2/PIK3CB/DNM2/GNA12/RALA/RAF1/MRAS/RHEB/PIK3CG/ADCY3/SOS2/MAPK1/KRAS/DGKD/SYK/PIK3R6/AKT3/PLA2G4A/PIP5K1A/RHOA/PLCB2/PTPN11/NRAS/ARF1/CXCR2/AGPAT4/CYTH3/PIK3CD/RALB/INSR/DGKA	3.16618601793949
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	88/1711	362/9376	1.33211491454385	PIK3R5/NFKB1/VEGFA/CDKN1A/EREG/ITGA5/FOXO3/EIF4E/IL6R/IL3RA/ITGAV/JAK1/MAP2K1/TLR2/PIK3AP1/SGK1/GRB2/PIK3R1/NR4A1/PIK3CB/MCL1/GNB1/PPP2R2A/BCL2/OSM/YWHAZ/PPP2CA/CSF3R/PHLPP1/IL4R/RAF1/ITGB8/BCL2L11/RHEB/LAMB3/YWHAG/RPTOR/PTEN/PIK3CG/ATF4/SOS2/MAPK1/IFNAR2/PPP2R2D/KRAS/RXRA/CDC37/CREB5/DDIT4/IL2RG/PDPK1/YWHAH/IFNAR1/SYK/AREG/GNG7/PPP2R5C/RELA/GSK3B/PIK3R6/ITGA4/AKT3/CDKN1B/PPP2R5A/CSF3/IL6/YWHAQ/MDM2/PPP2R3C/GYS1/NRAS/ATF2/CHUK/IGF1R/PIK3CD/THBS1/ITGB1/RAC1/CASP9/CCND3/GNG5/JAK3/CRTC2/TLR4/IKBKG/GNGT2/INSR/MET	3.04465754210447
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	30/1711	98/9376	1.6775009243908	INPP5A/PIK3R1/SYNJ2/PLCG2/PIK3CB/MTMR3/PRKCB/PTEN/SYNJ1/IPMK/ITPK1/PI4K2A/ITPR1/DGKD/PI4KB/PI4K2B/INPP5D/MTMR6/ITPKB/PIP5K1A/IP6K1/INPP4A/PIP4K2A/ITPKC/PLCB2/MTMR14/IP6K2/PIK3CD/IPPK/DGKA	3.18529976258682
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	23/1711	70/9376	1.80051765884612	NFKBIA/NFKB1/ACSL1/IRS2/ACSL5/ACSL3/ADIPOR2/TNFRSF1B/CAMKK2/PRKAG2/ACSL4/NFKBIE/STAT3/RXRA/CPT1A/TNF/MAPK8/RELA/NFKBIB/AKT3/PTPN11/CHUK/IKBKG	3.1760912831456
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	30/1711	99/9376	1.66055647060907	CDKN1A/BRAF/MAP2K1/GRB2/PIK3R1/HBEGF/PIK3CB/BCL2/NOTCH2/SRC/RAF1/MMP9/MAPK13/E2F3/ADCY3/SOS2/MAPK1/MAPK14/KRAS/NOTCH1/MAPK8/AKT3/NCOA3/CDKN1B/MDM2/MED1/NRAS/IGF1R/PIK3CD/ARAF	3.12160777326386
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	26/1711	83/9376	1.71657524311155	NFKBIA/NFKB1/TBK1/IL1B/ADAR/IL18/IRF7/CGAS/RIPK1/NLRP3/RELA/NFKBIB/G3BP1/PCBP1/DNASE2/IL6/MEFV/SAMHD1/CHUK/GSDME/IKBKE/POLR3E/MLKL/CASP8/CASP3/IKBKG	3.097971660927
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	23/1711	71/9376	1.7751582552004	HIF1A/SLC7A5/GLS/MAP2K1/SLC16A3/PIK3R1/PIK3CB/HK2/RAF1/PKM/SCO2/PTEN/MAPK1/KRAS/LDHA/HK1/AKT3/PDK1/NRAS/PFKP/PIK3CD/G6PD/MET	3.09753288310298
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	22/1711	67/9376	1.79934925024207	BRAF/MAP2K1/CREBBP/EP300/RAF1/PRKCB/RPS6KA3/ATF4/MAPK1/KRAS/RAP1A/ITPR1/RAP1B/GNAQ/PPP3R1/RPS6KA1/PPP1CB/PLCB2/NRAS/PPP3CA/ARAF/PPP3CC	3.10225163068545
Human Diseases	Cancer: specific types	hsa05214	Glioma	24/1711	76/9376	1.73047463779261	CDKN1A/BRAF/MAP2K1/GRB2/PIK3R1/PLCG2/PIK3CB/CAMK1D/RAF1/PRKCB/GADD45B/PTEN/E2F3/SOS2/MAPK1/KRAS/GADD45A/AKT3/MDM2/NRAS/IGF1R/PIK3CD/ARAF/CAMK1	3.02082124521629
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	32/1711	110/9376	1.59413421178471	SKIL/ZFYVE16/SMAD7/TGIF1/SKI/TGFB1/CREBBP/TFDP1/EP300/PPP2CA/ID2/SMAD3/EMP3/INHBA/CUL1/SMURF1/TGIF2/ROCK1/MAPK1/SIN3A/SMURF2/TNF/LEMD3/HAMP/RHOA/ACVR1/TGFBR1/ACVR1B/TFRC/TF/THBS1/BMP6	2.96134713282463
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	33/1711	115/9376	1.57247477955937	CDKN1A/OXSR1/BRAF/PDE4B/MAP2K1/GNA13/SGK1/MEF2D/AKAP13/HBEGF/VDR/GNA12/BCL2/PDE4A/RAF1/NR4A2/PRKCB/ADCY3/ATF4/MAPK1/GNAI3/RXRA/CREB5/ITPR1/RUNX2/GNAQ/MAFB/WNK1/RHOA/PLCB2/ATF2/ARAF/PDE4C	2.9183064834586
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	14/1711	37/9376	2.07345159303079	CDKN1A/BRAF/MAP2K1/GADD45B/PPARG/MAPK1/KRAS/RXRA/TPM3/GADD45A/TCF7L2/TCF7/NRAS/CTNNB1	3.0909195577437
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	12/1711	30/9376	2.19193454120397	NFKB1/IL1B/FPGS/TNF/ABCC3/RELA/ABCC1/IL6/CHUK/SLC19A1/GART/IKBKG	3.08926175446139
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	30/1711	103/9376	1.59606884068251	ETF1/PPP2R2A/PPP2CA/PABPC4/PABPC1/PCF11/NXF1/FUS/SMG1/HBS1L/PPP2R2D/GSPT1/SMG7/WDR33/PPP2R5C/RNMT/PAPOLA/EIF4A3/RBM8A/PPP1CB/CPSF6/RNGTT/PPP2R5A/NXT1/PPP2R3C/CPSF7/UPF3B/NXT2/CASC3/SMG5	2.87381935662587
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	29/1711	99/9376	1.60520458825544	HLA-DRB5/C5AR1/HLA-DQA1/FPR3/C3/HLA-DPB1/FPR1/HLA-DRB1/HLA-DQA2/HLA-DQB1/IL10/ICAM1/HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/FCAR/HLA-DOA/FCGR3B/DEFB1/CAMP/FCGR2B/PTAFR/HLA-DQB2/ITGB2/DEFA4/ITGAM/DEFA3/FPR2	2.86003003705521
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	29/1711	99/9376	1.60520458825544	HIF1A/GPCPD1/RALGDS/CHKA/MAP2K1/GRB2/PIK3R1/SLC22A4/PIK3CB/RAF1/RHEB/PRKCB/SOS2/MAPK1/KRAS/PDPK1/DGKD/SLC44A1/MAPK8/SLC22A1/AKT3/PLA2G4A/PIP5K1A/RAC2/PCYT1A/NRAS/PIK3CD/RAC1/DGKA	2.86003003705521
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	44/1711	166/9376	1.45248674417131	PIK3R5/PPIF/ATP2B1/IRS2/MAP2K1/GNA13/MEF2D/GNA12/RGS2/VASP/RAF1/PDE2A/PPP1R12A/KCNMA1/ATP2A2/PRKCE/ATP1B3/ATP2A3/ROCK1/PIK3CG/ADCY3/ATF4/MAPK1/ATP1A1/GNAI3/CREB5/ITPR1/NFATC1/GNAQ/ADRA2B/PIK3R6/PPP3R1/AKT3/KCNMB1/PPP1CB/SLC8A1/RHOA/PLCB2/PDE3B/PPP3CA/ATF2/ADRB2/PPP3CC/INSR	2.77897508522445
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	42/1711	157/9376	1.46594348297081	CXCL8/NFKB1/ERN1/EIF2AK3/IL6R/IRS2/BID/PIK3R1/IL1A/TGFB1/PIK3CB/ADIPOR2/IL1B/DDIT3/PRKAG2/BCL2L11/MAPK13/PPARG/ATF4/MAPK14/RXRA/TNF/MAPK8/RELA/GSK3B/CYCS/NDUFB9/AKT3/IL6/XBP1/SREBF1/SDHA/CDC42/PIK3CD/RAC1/NDUFV2/CASP8/CASP3/MAP3K11/MAP3K5/INSR/FAS	2.78160670056432
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	86/1711	368/9376	1.28061393032297	MAP2K3/ERN1/C9orf72/EIF2AK3/SQSTM1/DNAH17/BID/TBK1/RANBP2/MAP1LC3B/RAB1A/RB1CC1/NUP98/TNFRSF1B/TANK/BCL2/RAB5A/DDIT3/NXF1/HNRNPA2B1/FUS/TUBA1C/MAPK13/PSMA6/TUBB4B/ATF4/NUP58/TUBA4A/PSMD7/PSMD12/NUP153/HSPA5/ATG2A/UBQLN1/MCU/MAPK14/CHMP2B/RAB8A/PSMD14/TNF/PSMD1/TUBB6/CYCS/TOMM40L/NDUFB9/SEC13/PPP3R1/DCTN4/NUP62/BECN1/NRBF2/DERL1/ACTR1A/VAPB/PSMD11/ANXA7/NXT1/DNAI2/XBP1/HNRNPA3/SETX/POM121C/POM121/SDHA/NUP93/SRSF3/PPP3CA/NUP188/ATF6/MAP1LC3A/WIPI1/RAC1/NDUFV2/NUP210L/CASP9/PPP3CC/NUP88/CASP3/MAP1LC3B2/NUP50/ATG13/SMCR8/MAP3K5/APAF1/NXT2/DAXX	2.59461850132359
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	18/1711	55/9376	1.7934009882578	B4GALT5/SPHK1/PSAP/GALC/GM2A/SAMD8/SGMS2/UGCG/SGPP2/GLA/CERK/ASAH1/KDSR/SGPL1/HEXB/HEXA/NEU3/CERS6	2.78802967032034
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	16/1711	47/9376	1.86547620527998	IRS2/PIK3R1/PIK3CB/HK2/PKM/PRKCE/MAPK1/HK1/TNF/MAPK8/SOCS4/SOCS1/PRKCD/PIK3CD/CACNA1G/INSR	2.81022490325361
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	17/1711	51/9376	1.82661211766998	ATP6V1H/PLCG2/TJP2/ATP6V0D1/ATP6V1B2/ERO1A/ADCY3/TCIRG1/ATP6V1E1/SLC12A2/ATP6V1F/ATP6V1A/ATP6V1C1/ATP6V1D/ARF1/ATP6V0B/ATP6V0C	2.79651400541356
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	27/1711	93/9376	1.59092023151901	PTPRJ/CREBBP/PTPN1/ACTN1/EP300/SRC/SMAD3/SMURF1/ROCK1/SNAI1/MAPK1/RAP1A/IQGAP1/SMURF2/RAP1B/TCF7L2/RAC2/RHOA/TGFBR1/TCF7/CDC42/CTNNB1/IGF1R/RAC1/INSR/SORBS1/MET	2.70570672907572
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	11/1711	28/9376	2.15279285296819	ATP6V0D1/ATP6V1B2/CA2/TCIRG1/ATP6V1E1/SLC12A7/ATP6V1F/ATP6V1A/ATP6V1C1/ATP6V1D/ATP6V0C	2.88619388680247
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	12/1711	32/9376	2.05493863237873	GABARAPL1/PPP2CA/ATG3/ATG7/ATG4B/RPTOR/ATG2A/ATG16L1/BECN1/ATG12/WIPI1/ATG13	2.82416674185201
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	108/1711	480/9376	1.23296317942724	NFKB1/PTGS2/MAP2K3/PPIF/ERN1/C9orf72/EIF2AK3/BRAF/SQSTM1/MAP2K1/DNAH17/BID/TBK1/MAP1LC3B/RAB1A/RB1CC1/IL1A/PSEN1/ATXN1/IL1B/TNFRSF1B/TANK/CSNK1A1/BCL2/RAB5A/DDIT3/RAF1/UBC/ATP2A2/FUS/TUBA1C/CAPN2/PRKCB/PRNP/MAPK13/UBE2L6/ATP2A3/PSMA6/TUBB4B/ATF4/TUBA4A/PSMD7/PSMD12/HSPA5/MAPK1/ATG2A/MCU/MAPK14/CHMP2B/KRAS/UBE2G1/RAB8A/PSMD14/ITPR1/TNF/PSMD1/UBA1/APP/GNAQ/UBE2J1/MAPK8/RELA/GSK3B/TUBB6/CYCS/TOMM40L/NDUFB9/PPP3R1/DCTN4/BECN1/NRBF2/PPID/DERL1/ACTR1A/VAPB/PSMD11/DNAI2/IL6/XBP1/PLCB2/MFN2/MFN1/SDHA/NRAS/PPP3CA/WNT2B/CTNNB1/AXIN1/ATF6/SLC6A3/MAP1LC3A/WIPI1/ARAF/RAC1/HIP1/NDUFV2/CASP9/PPP3CC/ZFYVE1/CASP8/CASP3/MAP1LC3B2/ATG13/SMCR8/MAP3K5/APAF1/FAS/DAXX	2.4755122500059
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	28/1711	100/9376	1.53435417884278	CXCL8/CXCL2/CXCR4/IL6R/CXCL3/CCL20/TNFSF14/TNFRSF1B/IL10/IL18/CXCL1/IL10RA/TNFRSF10B/IL2RG/TNF/IL10RB/TNFRSF10D/CCL21/CCR5/IL6/IL19/TNFRSF10A/TNFRSF14/CXCR2/CCL3L1/IL18RAP/CCR7/TNFRSF10C	2.53806887618191
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	41/1711	160/9376	1.4042080654588	HLA-DRB5/HLA-B/HLA-A/ITGAV/HLA-DQA1/CD58/HLA-DPB1/HLA-DRB1/HLA-DQA2/HLA-DQB1/HLA-F/ICAM1/ALCAM/CD22/ITGB8/HLA-DRA/PTPRC/HLA-DMB/HLA-E/HLA-DMA/HLA-DPA1/SDC4/CD80/HLA-DOA/ITGA4/SDC2/VSIR/HLA-C/HLA-DQB2/CD226/ITGB2/CD274/CADM1/ICOSLG/ITGAM/ITGB1/SPN/F11R/SELL/JAML/ICAM3	2.43639835006627
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	43/1711	170/9376	1.38607625399663	CDKN1A/NFE2L2/BRAF/MAP2K1/GRB2/PIK3R1/TGFB1/PLCG2/PIK3CB/TXNRD1/CSNK1A1/RAF1/SMAD3/PRKCB/GADD45B/GSTO1/PTEN/E2F3/SMARCA2/SOS2/MAPK1/ARID2/KRAS/GADD45A/TCF7L2/GSK3B/AKT3/HMOX1/SMARCC1/ARID1A/PHF10/GSTO2/TGFBR1/TCF7/NRAS/WNT2B/CTNNB1/AXIN1/IGF1R/PIK3CD/ARAF/SMARCD3/MET	2.40002977430045
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	16/1711	50/9376	1.75354763296318	CXCL8/TLR2/TGFB1/IL1B/IL10/ICAM1/IL18/MYD88/TNF/SDC2/CSF3/IL6/ITGB2/THBS1/TLR4/MET	2.52407682860253
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	22/1711	76/9376	1.58626841797656	OLR1/ACSL1/PLIN2/ACSL5/PPARD/GK/ACSL3/UBC/ACSL4/APOA2/PPARG/RXRA/PDPK1/CPT1A/HMGCS1/ACOX3/APOC3/FABP5/ACOX1/APOA1/SCD/SORBS1	2.42446760064755
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	57/1711	238/9376	1.31239778202339	NFKB1/ETS2/GAB2/VEGFA/RASSF5/RALGDS/REL/PAK1/MAP2K1/TBK1/GRB2/PIK3R1/PLCG2/PIK3CB/RASGRP3/GNB1/SHOC2/RAB5A/PLA2G6/ABL2/RALA/RAF1/MRAS/RASA3/PRKCB/SOS2/MAPK1/KRAS/RAP1A/STK4/RAP1B/GNG7/MAPK8/RELA/AKT3/RALGAPA1/PLA2G4A/RAC2/RHOA/RALGAPA2/PTPN11/NRAS/CDC42/CHUK/IGF1R/PIK3CD/RALB/RAC1/RASA2/HTR7/GNG5/RASGRP2/IKBKG/GNGT2/INSR/RASAL3/MET	2.30635102251451
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	57/1711	238/9376	1.31239778202339	CXCL8/NFKBIA/NFKB1/IL6R/TRAF3/TAB2/MX1/C5AR1/JAK1/MX2/TLR2/IFIH1/TBK1/PIK3R1/C3/EIF2AK2/STAT1/HBEGF/PLCG2/PIK3CB/IL1B/ADAR/ADAM17/IRAK1/OAS2/STAT3/PRKCB/MAPK13/OAS3/CGAS/MYD88/MAPK1/IFNAR2/MAPK14/ISG15/TNF/IFNAR1/SYK/NLRP3/MAPK8/RELA/NFKBIB/TYK2/IRF9/STAT2/CSF3/IL6/RPS26/RPS4Y1/OAS1/CHUK/IKBKE/PIK3CD/TRAF6/CSF2/TLR4/IKBKG	2.30635102251451
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	34/1711	130/9376	1.43318796924875	NFKBIA/NFKB1/VEGFA/MAP2K1/GRB2/PIK3R1/TGFB1/PIK3CB/GNB1/SRC/RAF1/MMP9/GNA15/MAPK13/ADCY3/ATF4/SOS2/MAPK1/GNAI3/MAPK14/KRAS/CREB5/GNG7/MAPK8/RELA/AKT3/PLCB2/TGFBR1/NRAS/ATF2/MAP2K4/PIK3CD/GNG5/GNGT2	2.34977176839548
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	36/1711	140/9376	1.40910077648827	PIK3R5/SPHK1/MAP2K1/GNA13/MEF2D/MAP1LC3B/SLC9A1/GNB1/RAF1/SMAD3/MRAS/PRKAG2/PRKCE/PIK3CG/ADCY3/MAPK1/GNAI3/KRAS/ITPR1/GNG7/NRF1/HDAC4/GNAQ/PIK3R6/AKT3/BECN1/HDAC5/SLC8A1/PLCB2/PDE3B/TGFBR1/NRAS/MAP1LC3A/GNG5/MAP1LC3B2/GNGT2	2.30412970488376
Organismal Systems	Nervous system	hsa04730	Long-term depression	18/1711	60/9376	1.64395090590298	BRAF/MAP2K1/GNA13/LYN/GNA12/PPP2CA/RAF1/PRKCB/MAPK1/GNAI3/KRAS/ITPR1/GNAQ/PLA2G4A/PLCB2/NRAS/IGF1R/ARAF	2.36411286933061
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	87/1711	388/9376	1.22872619255635	NFKB1/PTGS2/PPIF/ERN1/EIF2AK3/BRAF/IRS2/MAP2K1/BID/PIK3R1/EIF2AK2/RB1CC1/IL1A/PSEN1/PIK3CB/IL1B/CSNK1A1/ADAM17/SLC39A8/RTN3/DDIT3/RAF1/ATP2A2/TUBA1C/CAPN2/RTN4/ATP2A3/PSMA6/TUBB4B/ATF4/TUBA4A/PSMD7/PSMD12/MAPK1/ATG2A/MCU/KRAS/SLC11A2/PSMD14/ITPR1/TNF/PSMD1/APP/GNAQ/MAPK8/SLC39A11/RELA/GSK3B/TUBB6/CYCS/NDUFB9/PPP3R1/AKT3/SLC39A9/BECN1/NRBF2/PPID/GAPDH/PSMD11/IL6/XBP1/APH1B/PLCB2/SDHA/NRAS/PPP3CA/WNT2B/CHUK/CTNNB1/AXIN1/ATF6/PIK3CD/WIPI1/ARAF/NDUFV2/CASP9/PPP3CC/SLC39A6/MME/CASP8/CASP3/ATG13/IKBKG/MAP3K5/INSR/APAF1/FAS	2.1739762484694
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	22/1711	78/9376	1.54559486879767	ITGA5/PIK3R1/ACTR3/ARHGAP10/PIK3CB/DNM2/SRC/SEPTIN6/CBL/HCLS1/CRK/SEPTIN9/RHOA/ACTR2/CDC42/CTNNB1/PIK3CD/ITGB1/RAC1/ARPC2/ARPC5/MET	2.2860060267404
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	25/1711	93/9376	1.47307428844353	PTK2B/MAP2K3/MAP3K2/MAP2K1/GRB2/HBEGF/SRC/RAF1/PRKCB/MAPK13/ADCY3/ATF4/SOS2/MAPK1/MAPK14/KRAS/ITPR1/GNAQ/MAPK8/PLA2G4A/PRKCD/PLCB2/NRAS/CDC42/MAP2K4	2.16611349099355
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	18/1711	62/9376	1.59092023151901	SOD2/FOXO3/IRS2/PIK3R1/PIK3CB/PRKAG2/FOXO1/RPTOR/ADCY3/KRAS/HSPA6/SIRT1/AKT3/NRAS/HSPA8/IGF1R/PIK3CD/INSR	2.2055207630416
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	28/1711	107/9376	1.43397586807737	PPP4R3A/CREBBP/EP300/PKM/PRKAG2/FOXO1/ATF4/CREB5/FBP1/CPT1A/ITPR1/LDHA/SIRT1/GNAQ/PPP4R3B/PPP3R1/AKT3/PLCB2/PDE3B/SIK2/GYS1/PFKP/PPP3CA/ATF2/PPP3CC/PYGM/CRTC2/PHKA2	2.13302326172948
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/1711	37/9376	1.77724422259782	IL1B/IL10/ICAM1/IL18/PRKCB/MYD88/TNF/GNAQ/IL6/PLCB2/APOA1/FAS	2.2380136974672
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	27/1711	104/9376	1.42264982241604	GPCPD1/LPCAT1/CHKA/PGS1/PLA2G6/SAMD8/GPAT3/SGMS2/GPD2/PNPLA6/LPIN2/DGKD/PTDSS1/LPCAT2/LPIN1/GPAT4/PLA2G4A/PISD/LPGAT1/MBOAT7/PCYT1A/LPCAT3/AGPAT4/PLB1/MBOAT2/PLPP5/DGKA	2.04769472907501
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/1711	34/9376	1.77288823185616	BHLHE40/NFIL3/CSNK1D/PRKAG2/CUL1/CRY1/FBXW11/NR1D2/PER1/FBXL3/CRY2	2.13299965457323
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	16/1711	56/9376	1.56566752943141	CSNK1A1/BCL2/SPOPL/CSNK1D/CUL3/CUL1/SMURF1/SMURF2/PTCH2/FBXW11/GSK3B/CSNK1G2/MGRN1/IQCE/SCUBE2/CSNK1G1	2.00586578604079
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	18/1711	65/9376	1.51749314391044	GK/MGLL/GPAT3/GLA/LPIN2/DGKD/LPIN1/GPAT4/MOGAT1/ALDH2/PNPLA2/ALDH3A2/AGPAT4/TKFC/MBOAT2/PLPP5/DGKA/DGAT1	1.97796079267606
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	15/1711	52/9376	1.58072202490671	ABCA1/NPC1/SOAT1/VAPA/APOA2/LIPA/MYLIP/APOC2/NCEH1/LDLR/VAPB/APOC3/SORT1/APOA1/APOB	1.98391655062986
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	29/1711	116/9376	1.36995908825248	SDS/OGDH/HK2/SDSL/PKM/PGK1/FBP1/HK1/GPI/PGD/ACAT2/ENO1/MDH2/ADPGK/GAPDH/ACOX3/GLUD1/TKT/SDHA/DLST/PFKP/ACOX1/ENO3/G6PD/ACAT1/ALDOA/TKFC/PRPS2/ALDOC	1.8942258766301
NA	NA	hsa04518	Integrin signaling	37/1711	154/9376	1.31658405884005	LIMS1/ITGAX/VEGFA/ITGA5/ITGAV/PIK3R1/C3/TGFB1/PIK3CB/ACTN1/ICAM1/SRC/ITGB8/LAMB3/TLN1/FLNA/FERMT3/PARVB/ITGAD/GSK3B/ITGA4/AKT3/PARVG/RAC2/ICAM4/ITGB2/CDC42/CTNNB1/IGF1R/PIK3CD/THBS1/ITGAM/ITGB1/RAC1/CCND3/ICAM3/MET	1.87150679218245
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	11/1711	35/9376	1.72223428237455	PFKFB3/HK2/FBP1/HK1/GMDS/PFKP/PFKFB4/ALDOA/TKFC/ALDOC/PFKFB2	2.02241370109601
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	10/1711	31/9376	1.76768914613224	FBP1/GPI/PGD/RBKS/TKT/PFKP/G6PD/ALDOA/PRPS2/ALDOC	2.02269852549676
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	7/1711	19/9376	2.01888707742471	IDS/GNS/HPSE/ARSB/HGSNAT/HEXB/HEXA	2.10033758108224
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	13/1711	44/9376	1.61904255884384	TAF4B/CCNH/TAF7/GTF2B/GTF2A1/GTF2H1/TAF13/TAF5L/TAF2/TAF11/TAF9/GTF2F2/CDK7	1.94452729711493
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	25/1711	99/9376	1.38379705884089	MAP2K3/PRKCH/PIK3R1/PLCG2/PIK3CB/IL1B/PLA2G6/SRC/PTGER4/IL1R1/PRKCB/PRKCE/MAPK13/ADCY3/MAPK14/ITPR1/IL1RAP/GNAQ/MAPK8/PLA2G4A/PRKCD/PPP1CB/PTGER2/PLCB2/PIK3CD	1.81371909222062
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	11/1711	36/9376	1.67439444119748	B4GALT5/ST3GAL1/GALNT11/GALNT2/GALNT7/C1GALT1/ST6GALNAC3/GALNT3/ST3GAL2/GALNT1/GALNT4	1.91534211232567
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	51/1711	226/9376	1.23660023895357	NFKBIA/NFKB1/ATP2B1/BRAF/PDE4B/PAK1/MAP2K1/PIK3R1/VAV1/CREBBP/PIK3CB/SLC9A1/EP300/PDE4A/HCAR3/RAF1/PPP1R12A/ATP2A2/HCAR2/ADORA2A/ATP1B3/ATP2A3/ROCK1/ADCY3/MAPK1/ATP1A1/GNAI3/CREB5/RAP1A/RAP1B/NFATC1/MAPK8/RELA/AKT3/POPDC2/PPP1CB/PTGER2/RAC2/ACOX3/RHOA/FFAR2/PDE3B/VAV2/SUCNR1/ADRB2/PIK3CD/ACOX1/RAC1/VAV3/SSTR2/PDE4C	1.70103564705543
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	7/1711	20/9376	1.91794272355348	SOAT1/LIPA/CYP51A1/LBR/SC5D/SQLE/FDFT1	1.94151181696873
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	37/1711	158/9376	1.2832528168441	CDKN1A/TGFB1/CREBBP/TFDP1/EP300/YWHAZ/PPP2CA/MAD1L1/SMAD3/NIPBL/CUL1/GADD45B/YWHAG/DBF4/STAG2/E2F3/WAPL/CCNH/ZBTB17/PRKDC/YWHAH/GADD45A/PPP2R5C/GSK3B/RAD21/CDKN1B/PPP2R5A/YWHAQ/MDM2/STAG1/CDC14A/FZR1/PTTG1/ESCO1/CCND3/TFDP2/CDK7	1.69644190765642
Human Diseases	Cancer: specific types	hsa05218	Melanoma	19/1711	73/9376	1.42625877681081	CDKN1A/BRAF/MAP2K1/PIK3R1/PIK3CB/RAF1/GADD45B/PTEN/E2F3/MAPK1/KRAS/GADD45A/AKT3/MDM2/NRAS/IGF1R/PIK3CD/ARAF/MET	1.7273399491927
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	10/1711	33/9376	1.66055647060907	STX11/STX3/STX4/SEC22B/STX6/STX5/STX18/VTI1A/GOSR1/VAMP1	1.79588411908973
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	39/1711	170/9376	1.25713892804346	RAB8B/MYH9/ACTR3/ARHGEF2/ACTN1/VASP/PPP2R2A/TJP2/PPP2CA/SRC/RAPGEF2/PRKAG2/TUBA1C/PRKCE/RUNX1/ROCK1/TUBA4A/EZR/RAP2C/PPP2R2D/HCLS1/RAB8A/RAP1A/RAPGEF6/MSN/MAPK8/WHAMM/RDX/RHOA/MICALL2/ACTR2/CDC42/ITGB1/RAC1/F11R/PRKCI/MAP3K5/ARPC2/ARPC5	1.59849531549118
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	11/1711	38/9376	1.58626841797656	SGK1/PIK3R1/PIK3CB/PRKCB/ATP1B3/MAPK1/ATP1A1/KRAS/PDPK1/PIK3CD/INSR	1.71086572731687
Organismal Systems	Digestive system	hsa04978	Mineral absorption	16/1711	61/9376	1.43733412537966	ATP2B1/FTH1/VDR/ATP1B3/ATP1A1/SLC11A2/SLC30A1/HMOX1/SLC8A1/MT1F/SLC31A1/MT1M/TRPM7/TF/MT1A/MT1H	1.61897975537254
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/1711	43/9376	1.52925665665394	ACSL1/ACSL5/ACSL3/ACSL4/CPT1A/ACADVL/ACAT2/ACOX3/ALDH2/ALDH3A2/ACOX1/ACAT1	1.64340455836724
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	21/1711	85/9376	1.35384192250834	AMPD3/UPP1/PNP/ADA/NT5C2/ADK/ADA2/ASMTL/TYMP/CMPK2/RRM1/LACC1/AMPD2/UCK2/AK2/AK4/NT5C3A/CDA/ENTPD4/ENTPD1/CANT1	1.54825354183388
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	15/1711	57/9376	1.44206219816051	ACSL1/ACSL5/ELOVL5/ACSL3/ACSL4/ELOVL7/CPT1A/ACADVL/ACAT2/PPT1/ACOX3/OXSM/ACOX1/ACAT1/SCD	1.58157836050425
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	64/1711	298/9376	1.17687760601556	CXCL8/CXCL2/CXCR4/IL6R/IL3RA/CXCL3/CCL20/IL1A/TGFB1/TNFSF14/IL1B/IL1RN/RELT/TNFRSF1B/CSF2RA/OSM/CXCL16/CSF3R/IL10/IL18/IL4R/IFNGR2/INHBA/IL1R1/IFNGR1/IL1R2/CXCL1/IL10RA/IFNAR2/IL1RL2/IL13RA1/TNFRSF10B/IL2RG/IL1RAP/TNF/TNFSF13B/IFNAR1/IL10RB/TNFRSF10D/TNFSF8/CLCF1/CCL21/CCR5/TNFSF13/CSF3/IL6/ACVR1/IL19/TNFRSF10A/TGFBR1/TNFRSF14/CXCR2/ACVR1B/IL17RA/CRLF2/CSF2RB/CCL3L1/IL18RAP/CSF2/TNFSF9/BMP6/CCR7/TNFRSF10C/FAS	1.4660218992073
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	33/1711	144/9376	1.25579583089811	PPIF/ERN1/PIK3R1/RB1CC1/PIK3CB/ATXN1/ATP2A2/PRKCB/ATP2A3/PSMA6/PSMD7/PSMD12/ATG2A/MCU/PSMD14/ITPR1/PSMD1/GTF2B/GNAQ/MAPK8/CYCS/PUM1/AKT3/BECN1/NRBF2/PSMD11/XBP1/PLCB2/PIK3CD/WIPI1/PUM2/ATG13/MAP3K5	1.46144129023945
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	17/1711	67/9376	1.39040623882342	HK2/PKM/PGK1/FBP1/LDHA/HK1/GPI/ENO1/ADPGK/GAPDH/ALDH2/PFKP/ALDH3A2/ENO3/ALDH3B1/ALDOA/ALDOC	1.51515547259592
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	35/1711	154/9376	1.2454173529568	PIK3R5/ATP2B1/SLC9A1/PPP2R2A/BCL2/PPP2CA/ATP2A2/MAPK13/ATP1B3/ATP2A3/PIK3CG/ADCY3/ATF4/MAPK1/ATP1A1/GNAI3/PPP2R2D/MAPK14/CREB5/TPM3/CREM/TPM4/PPP2R5C/GNAQ/PIK3R6/AKT3/POPDC2/PPP1CB/SLC8A1/PPP2R5A/PPP2R3C/PLCB2/ATF2/ADRB2/KCNE1	1.45080028558909
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	35/1711	154/9376	1.2454173529568	PIK3R5/PTGS2/CDKN1A/MAP2K1/CAMK1D/RGS2/CAMKK2/SRC/RAF1/PPP1R12A/PRKAG2/PRKCB/ROCK1/PIK3CG/ADCY3/MAPK1/GNAI3/KRAS/ITPR1/NFATC1/GNAQ/PIK3R6/PPP3R1/CD38/TRPM2/PLA2G4A/PPP1CB/RHOA/PLCB2/PPP1R12C/NRAS/PPP3CA/PPP3CC/PPP1R12B/CAMK1	1.45080028558909
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	14/1711	54/9376	1.42069831374332	SDS/BCAT1/SDSL/IL4I1/MAT2A/GCLC/LDHA/SMS/LACC1/AHCYL1/MDH2/AMD1/AHCY/GCLM	1.46476402574457
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/1711	59/9376	1.39317873381609	UPP1/NT5C2/ASMTL/TYMP/CMPK2/RRM1/DPYD/UCK2/CDADC1/UPB1/NT5C3A/CDA/ENTPD4/ENTPD1/CANT1	1.43130616270035
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	7/1711	23/9376	1.66777628135085	IDI1/HMGCS1/NUS1/ACAT2/PDSS1/HMGCR/ACAT1	1.51486525098676
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	49/1711	227/9376	1.18287216430611	SOD2/NFKBIA/NFKB1/VEGFA/PPIF/HIF1A/FOXO3/NFE2L2/BRAF/MAP2K1/GRB2/PIK3R1/PTPRJ/PIK3CB/PTPN1/NCF2/ABL2/SRC/RAF1/MAPK13/GSTO1/PTEN/SOS2/MAPK1/MAPK14/KRAS/PDPK1/AHR/MAPK8/RELA/NDUFB9/AKT3/PRKCD/HMOX1/GSTO2/PRKD3/SDHA/NCF1/PTPN11/NRAS/CHUK/MAP2K4/PIK3CD/ARAF/RAC1/NDUFV2/IKBKG/MAP3K5/MET	1.31773561210847
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	5/1711	15/9376	1.82661211766998	ST3GAL1/HEXB/HEXA/ST6GALNAC3/ST3GAL2	1.51370357904694
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	30/1711	134/9376	1.22682903425596	BRAF/PRKCH/MAP2K1/GNA13/MYH9/GNA12/ADM/PLA2G6/RAF1/PPP1R12A/KCNMA1/PRKCB/PRKCE/ADORA2A/ROCK1/ADCY3/MAPK1/ITPR1/GNAQ/KCNMB1/PLA2G4A/PRKCD/ADORA2B/PPP1CB/RHOA/ACTG2/PLCB2/PPP1R12C/ARAF/PPP1R12B	1.24946076801459
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	32/1711	144/9376	1.21774141177999	SKIL/JARID2/JAK1/MAP2K1/GRB2/PIK3R1/PIK3CB/ID2/RAF1/SMAD3/INHBA/KAT6A/STAT3/PCGF5/MAPK13/MAPK1/MAPK14/KRAS/GSK3B/AKT3/ACVR1/RIF1/TCF7/NRAS/ACVR1B/WNT2B/CTNNB1/AXIN1/IGF1R/PIK3CD/JAK3/SETDB1	1.24402453571284
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/1711	24/9376	1.59828560296123	HS3ST1/XYLT1/HS3ST3B1/NDST1/NDST2/HS3ST2/EXTL3	1.38648918827778
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	25/1711	110/9376	1.2454173529568	BRAF/STK10/MAP2K1/PIK3R1/CPEB2/PIK3CB/RAF1/MAD1L1/CPEB4/MAPK13/RPS6KA3/ADCY3/MAPK1/GNAI3/MAPK14/KRAS/SPDYA/MAPK8/RPS6KA1/AKT3/PDE3B/FZR1/IGF1R/PIK3CD/ARAF	1.22323535677389
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/1711	38/9376	1.44206219816051	UAP1/HK2/GNPDA1/HK1/GPI/UGP2/HEXB/HEXA/UXS1/GFPT1	1.29003889853984
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	10/1711	38/9376	1.44206219816051	CIITA/ADA/PTPRC/TAP1/IL2RG/BTK/TAP2/RFX5/JAK3/IKBKG	1.29003889853984
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/1711	16/9376	1.7124488603156	ST3GAL1/GLA/HEXB/HEXA/ST3GAL2	1.34750481716558
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	15/1711	63/9376	1.30472294119284	DOT1L/KMT2E/EZH2/PRDM2/KMT2C/SETDB2/ACAT2/ALDH2/DLST/ALDH3A2/KMT2D/ACAT1/ASH1L/SETD1A/SETDB1	1.14652938011465
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	32/1711	148/9376	1.18482948173188	CDKN1A/BRAF/MAP2K1/GRB2/PIK3R1/PIK3CB/CSNK1A1/NOTCH2/NFKB2/RAF1/GADD45B/PTEN/E2F3/SOS2/MAPK1/KRAS/NOTCH1/BRCA2/GADD45A/TCF7L2/GSK3B/AKT3/NCOA3/HES1/TCF7/NRAS/WNT2B/CTNNB1/AXIN1/IGF1R/PIK3CD/ARAF	1.07078646727888
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	28/1711	128/9376	1.19871420222092	AMPD3/PDE4B/PNP/PDE7A/ADA/PDE4A/PDE2A/NT5C2/ADK/ADA2/ADCY3/RRM1/PDE8A/LACC1/PDE1B/AMPD2/AK2/AK4/ENPP4/PDE3B/ENTPD4/ENTPD1/PAPSS2/PDE6A/GART/PRPS2/CANT1/PDE4C	1.06945999866082
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	22/1711	98/9376	1.23016734455325	ATP2B1/NR4A1/CAMK1D/PDE2A/NR4A2/PRKCB/PRKCE/ATP1B3/ADCY3/ATF4/ATP1A1/CREB5/ITPR1/ATF1/GNAQ/LDLR/PRKD3/PLCB2/DAGLB/ATF2/CACNA1G/CAMK1	1.08214167917181
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	6/1711	21/9376	1.56566752943141	DSE/CHST15/CSGALNACT2/CHST11/CHSY1/XYLT1	1.22603696630418
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	6/1711	21/9376	1.56566752943141	PPCDC/BCAT1/DPYD/ALDH2/UPB1/ALDH3A2	1.22603696630418
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	14/1711	59/9376	1.30030015156168	PTGS2/IRS2/PIK3R1/PIK3CB/MGLL/ADCY3/GNAI3/ABHD5/AKT3/PDE3B/PNPLA2/ADRB2/PIK3CD/INSR	1.0931960979129
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	30/1711	139/9376	1.18269849345538	MAP2K1/GRB2/PIK3R1/HBEGF/PIK3CB/RARA/BCL2/SRC/RAF1/MMP9/FKBP5/ADCY3/ATF4/SOS2/MAPK1/GNAI3/CTSD/KRAS/CREB5/HSPA6/ITPR1/GNAQ/AKT3/PRKCD/NCOA3/PLCB2/NRAS/HSPA8/ATF2/PIK3CD	1.0252539657331
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	7/1711	26/9376	1.4753405565796	ABCC1/SLC19A2/SLC19A1/PLB1/BTD/APOA1/APOB	1.14667488972194
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	20/1711	89/9376	1.23142389955279	MAP3K2/MAP2K1/GRB2/CSNK1D/SRC/RAF1/TUBA1C/PRKCB/TUBB4B/ADCY3/TUBA4A/SOS2/MAPK1/GNAI3/KRAS/ITPR1/GNAQ/TUBB6/PLCB2/NRAS	1.03638245270713
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	45/1711	217/9376	1.13637159394215	NFKB1/VEGFA/BCL6/MAP2K1/GRB2/PIK3R1/VDR/PIK3CB/BCL2/NOTCH2/KPNA4/SRC/RAF1/STAT3/PRKCB/RPS6KA3/STAT5B/GSTO1/ADCY3/ATF4/SOS2/MAPK1/GNAI3/KRAS/RXRA/KPNA1/CREB5/AHR/KPNB1/KLF5/STAT5A/RELA/KPNA2/RPS6KA1/AKT3/KPNA3/GSTO2/NRAS/ATF2/ADRB2/IKBKE/PIK3CD/KPNA6/CCND3/XIAP	0.960250003572383
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	15/1711	65/9376	1.26457761992537	MAP2K1/PIK3R1/PIK3CB/RAF1/PRKCB/MAPK1/KRAS/ITPR1/KCNN4/GNAQ/AKT3/PLCB2/NRAS/PIK3CD/CACNA1G	1.01126781096542
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	17/1711	75/9376	1.24209624001559	SDS/GLUL/BCAT1/SDSL/PKM/PGK1/MAT2A/ARG1/ENO1/GAPDH/TKT/ASL/PFKP/ENO3/ALDOA/PRPS2/ALDOC	0.994508312245461
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	9/1711	36/9376	1.36995908825248	MGAM/GBE1/HK2/GYG1/HK1/GPI/UGP2/GYS1/PYGM	1.050717767349
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	5/1711	18/9376	1.52217676472498	ACSL1/ACSL5/ACSL3/ACSL4/OXSM	1.04765149878404
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	25/1711	117/9376	1.1709052036346	BAZ1A/GATAD2A/GATAD2B/CHD4/SMARCA2/ARID2/SMARCA5/EPC2/BICRAL/MBD2/CHD3/SMARCC1/SRCAP/EPC1/INO80D/ARID1A/PHF10/BPTF/INO80/SS18L1/BCL7B/ING3/RSF1/SMARCD3/BAZ2B	0.878862103872888
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	22/1711	102/9376	1.1819254879041	ATP2B1/SLC9A1/KCNMA1/ATP2A2/PRKCB/ATP1B3/ATP2A3/ADCY3/ATP1A1/RAB8A/RAP1A/CA2/ITPR1/RAP1B/TPCN2/GNAQ/SLC12A2/CD38/RHOA/PLCB2/BST1/RAC1	0.872799827610258
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	29/1711	138/9376	1.15155981331368	MAP2K1/CPEB2/YWHAZ/PPP2CA/MAD1L1/CUL1/CPEB4/YWHAG/MAPK13/RPS6KA3/ADCY3/MAPK1/MAPK14/ITPR1/YWHAH/FBXW11/PPP2R5C/SPDYA/PPP3R1/RPS6KA1/SLK/PPP1CB/PPP2R5A/YWHAQ/REC8/PPP3CA/IGF1R/PTTG1/PPP3CC	0.847401423622908
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	40/1711	195/9376	1.12406899548922	NFKB1/AQP9/PPIF/C5AR1/MAP2K1/TLR2/FPR3/PIK3R1/C3/FPR1/PLCG2/PIK3CB/NCF2/SRC/RAF1/ATG7/PRKCB/MAPK13/MAPK1/MAPK14/FCGR3B/CAMP/SYK/HDAC4/RELA/AKT3/RAC2/CLEC7A/HDAC5/PLCB2/NCF1/AZU1/ITGB2/PIK3CD/ITGAM/MPO/RAC1/TLR4/FPR2/PADI4	0.827161174845969
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	28/1711	133/9376	1.15364975852841	GNB1/PPP2R2A/PPP2CA/PRKCB/MAPK13/ATF4/GNAI3/PPP2R2D/MAPK14/CREB5/ITPR1/GNAL/GNG7/PPP2R5C/GNAQ/MAPK8/GSK3B/AKT3/PPP1CB/PPP2R5A/PPP2R3C/PLCB2/PPP3CA/ATF2/SLC6A3/PPP3CC/GNG5/GNGT2	0.843151834764605
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	6/1711	23/9376	1.42952252687216	ANPEP/CTSA/ATP6AP2/PREP/MME/NLN	0.974381343941136
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1711	14/9376	1.56566752943141	ST3GAL1/B4GALT1/B3GNT2/ST3GAL2	1.00068067494458
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	9/1711	38/9376	1.29785597834446	NAMPT/PNP/NT5C2/SIRT1/NADK/CD38/SIRT2/BST1/SIRT7	0.869212069762802
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	31/1711	150/9376	1.13249951295539	CDKN1A/BRAF/MAP2K1/GRB2/PIK3R1/TGFB1/PIK3CB/CSNK1A1/BCL2/RAF1/SMAD3/GADD45B/E2F3/SOS2/MAPK1/KRAS/RXRA/GADD45A/TCF7L2/GSK3B/AKT3/CDKN1B/TGFBR1/TCF7/NRAS/WNT2B/CTNNB1/AXIN1/PIK3CD/ARAF/MET	0.772872313053782
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	14/1711	63/9376	1.21774141177999	ERCC1/CCNH/CUL4A/POLR2A/POLE4/RAD23B/ERCC6/GTF2H1/ERCC8/XPC/RPA2/ERCC5/CDK7/UVSSA	0.819258717102658
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	11/1711	48/9376	1.25579583089811	PIK3R1/MGAM/PIK3CB/HK2/PRKCB/ATP1B3/ATP1A1/HK1/AKT3/PLCB2/PIK3CD	0.839410457055488
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	24/1711	115/9376	1.14361802149773	PIK3R5/MAP2K1/PIK3R1/PIK3CB/GNB1/BCL2/PRKCB/PIK3CG/ADCY3/ATF4/MAPK1/GNAI3/KRAS/CREB5/ITPR1/GNG7/GNAQ/PIK3R6/AKT3/PLCB2/NRAS/PIK3CD/GNG5/GNGT2	0.732122039683394
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1711	10/9376	1.64395090590298	SQOR/ETHE1/PAPSS2	0.962565396689508
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	32/1711	157/9376	1.11690932035871	SMAD7/TP53BP2/TGFB1/BIRC2/LATS2/PPP2R2A/YWHAZ/PPP2CA/ID2/CSNK1D/SMAD3/YWHAG/PPP2R2D/BIRC3/YWHAH/FBXW11/AREG/SAV1/TCF7L2/MOB1A/GSK3B/PPP1CB/YWHAQ/TGFBR1/TCF7/ITGB2/WNT2B/CTNNB1/AXIN1/CCND3/BMP6/PRKCI	0.69792960037728
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	37/1711	184/9376	1.10192361446395	CXCR4/PAK1/PIK3R1/LIMK2/PLXNC1/SEMA4D/PLCG2/SEMA6B/SSH1/PIK3CB/SRC/SEMA4A/RAF1/ROCK1/MAPK1/GNAI3/KRAS/PDPK1/GSK3B/SSH2/EPHB2/PPP3R1/RAC2/RHOA/SEMA3C/EPHB1/PTPN11/NRAS/CDC42/PPP3CA/SRGAP1/PIK3CD/ITGB1/RAC1/PPP3CC/EPHB6/MET	0.659679948363484
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1711	20/9376	1.36995908825248	CYB5R4/UAP1/UGP2/GMDS/NPL	0.782488845117282
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	63/1711	323/9376	1.06882257040132	NFKB1/PTGS2/CD44/VEGFA/CDKN1A/ITGA5/IRS2/VIM/GLS/MAP2K1/EZH2/GRB2/PIK3R1/PLCG2/CREBBP/PIK3CB/ST14/SLC7A1/MCL1/EP300/BCL2/NOTCH2/RAF1/PLAU/MMP9/BCL2L11/STAT3/PRKCB/PRKCE/RPTOR/PTEN/E2F3/ROCK1/SOS2/MAPK1/EZR/KRAS/CRK/DDIT4/NOTCH1/SIRT1/HDAC4/ABCC1/FOXP1/ZEB2/SOCS1/HMOX1/RDX/HDAC5/RHOA/CDKN1B/ZEB1/MDM2/PDCD4/DICER1/NRAS/SOX4/PIK3CD/THBS1/HMGA2/MDM4/CASP3/MET	0.594689749941538
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	10/1711	46/9376	1.19126877239346	PSMA6/PSMB9/PSMD7/PSMD12/PSME4/PSMD14/PSMD1/PSMD11/PSME1/PSME2	0.614379516490089
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	7/1711	31/9376	1.23738240229257	DPYD/ACOX3/ALDH2/UPB1/ALDH3A2/ACOX1/ALDH3B1	0.625452421094075
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	23/1711	115/9376	1.09596727060199	PTGS2/BRAF/MAP2K1/GNB1/RAF1/PRKCB/MAPK1/GNAI3/KRAS/ITPR1/GNG7/APP/GNAQ/ALOX5/PLA2G4A/DUSP1/PLCB2/NRAS/ARAF/HTR7/GNG5/CASP3/GNGT2	0.489212657041705
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	8/1711	37/9376	1.18482948173188	UAP1/HK2/HK1/GPI/UGP2/GMDS/UXS1/GFPT1	0.53220197691421
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	7/1711	32/9376	1.19871420222092	MGAM/B4GALT1/HK2/GLA/HK1/UGP2/PFKP	0.531976006775448
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	16/1711	79/9376	1.10984027402733	ATP6V1H/NAPA/DNM2/STX3/ATP6V0D1/ATP6V1B2/TCIRG1/ATP6V1E1/SLC1A3/ATP6V1F/ATP6V1A/ATP6V1C1/ATP6V1D/ATP6V0B/SLC6A3/ATP6V0C	0.463189068471034
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/1711	17/9376	1.28937325953175	GLUL/CA2/GLUD1/CA13	0.56418650863816
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1711	12/9376	1.36995908825248	NPC1/FCGR2B/CD46	0.605854285711805
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	30/1711	155/9376	1.06061348767934	CDKN1A/BRAF/MAP2K1/NR4A1/E2F3/ADCY3/ATF4/MAPK1/GNAI3/CREB5/RAP1A/ITPR1/RAP1B/AHR/GNAQ/TCF7L2/GSK3B/PDE8A/NCEH1/USP8/LDLR/CDKN1B/PLCB2/TCF7/ATF2/WNT2B/CTNNB1/AXIN1/KMT2D/CACNA1G	0.359501473959461
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	15/1711	75/9376	1.09596727060199	ALB/PRKCB/ATP1B3/ADCY3/ATF4/HSPA5/ATP1A1/CREB5/ITPR1/GNAQ/CANX/PLCB2/ATF2/TG/TTF2	0.394224413857239
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	10/1711	49/9376	1.11833394959386	B4GALT1/GALNT11/GALNT2/LFNG/GALNT7/OGT/C1GALT1/GALNT3/GALNT1/GALNT4	0.392365645841055
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/1711	44/9376	1.12087561766112	B4GALT1/STT3B/MAN2A1/MAGT1/MGAT4A/MGAT1/HEXB/HEXA/ALG13	0.379692695986308
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	5/1711	23/9376	1.19126877239346	GLS/GLUL/ARG1/GLUD1/ASL	0.433897436895518
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/1711	23/9376	1.19126877239346	GLS/ATP1B3/ATP1A1/CA2/GLUD1	0.433897436895518
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	34/1711	178/9376	1.04671031461988	PPARD/CREBBP/PSEN1/FOSL1/EP300/CSNK1A1/TLE3/SMAD3/CUL1/PRKCB/SIAH1/TLE4/CTBP2/SIRT1/NFATC1/FBXW11/MAPK8/TCF7L2/GSK3B/TBL1X/PPP3R1/RAC2/RHOA/SENP2/PLCB2/TCF7/PPP3CA/WNT2B/CTNNB1/AXIN1/RAC1/PPP3CC/CCND3/TBL1XR1	0.29725601709319
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/1711	39/9376	1.12406899548922	MTHFD2/MAT2A/MTHFD2L/MTHFS/MTHFD1L/AHCYL1/GART/AHCY	0.366814465135686
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	4/1711	18/9376	1.21774141177999	MANBA/HEXB/HEXA/NEU3	0.436858036988297
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	22/1711	116/9376	1.03927930832947	GLS/GLUL/GNB1/SLC38A2/HOMER1/PRKCB/ADCY3/MAPK1/GNAI3/ITPR1/GNG7/GNAQ/SLC1A3/PPP3R1/PLA2G4A/PLCB2/SLC38A1/PPP3CA/PPP3CC/GNG5/GNGT2/DLGAP1	0.201113811273742
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	8/1711	41/9376	1.06923636156291	NBN/BRCA2/RBBP8/TOP3A/BARD1/UIMC1/BLM/RPA2	0.209905378962433
Organismal Systems	Endocrine system	hsa04924	Renin secretion	13/1711	69/9376	1.03243293607434	KCNMA1/PTGER4/GNAI3/ITPR1/GNAQ/PDE1B/PPP3R1/PTGER2/PLCB2/PDE3B/PPP3CA/ADRB2/PPP3CC	0.127749885000062
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	8/1711	42/9376	1.04377835295427	KMO/IL4I1/KYNU/ACAT2/ALDH2/DLST/ALDH3A2/ACAT1	0.134339809665252
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	49/1711	268/9376	1.0019103779757	PPIF/NFE2L2/ERN1/EIF2AK3/SLC39A8/DDIT3/UBC/TUBA1C/ADORA2A/UBE2L6/PSMA6/TUBB4B/ATF4/TXN/TUBA4A/PSMD7/PSMD12/HSPA5/GNAI3/MCU/UBE2G1/SLC11A2/PSMD14/ITPR1/GNAL/PSMD1/UBA1/UBE2J1/MAPK8/SLC39A11/TUBB6/CYCS/NDUFB9/SLC39A9/DUSP1/PSMD11/XBP1/MFN2/MFN1/SDHA/ATF6/SLC6A3/NDUFV2/CASP9/SLC39A6/CASP3/MAP3K5/APAF1/DAXX	0.014990970585609
NA	NA	hsa03272	Virion - Hepatitis viruses	9/1711	48/9376	1.02746931618936	CHMP4B/CHMP1B/PDCD6IP/LAMP2/VPS4B/IST1/TSG101/LDLR/SLC10A1	0.0901423263098432
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/1711	26/9376	1.05381468327114	PLA2G6/PLA2G4A/ACOX3/PLB1/ACOX1	0.129818390522762
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	12/1711	65/9376	1.0116620959403	NR4A1/ADCY3/ATF4/CREB5/ITPR1/GNAQ/PDE8A/NCEH1/LDLR/PLCB2/ATF2/CACNA1G	0.0445748292547889
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	3/1711	15/9376	1.09596727060199	AK2/AK4/ALPL	0.175736597463711
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	50/1711	275/9376	0.996333882365443	PPIF/EIF2AK3/PIK3R1/IL1A/PIK3CB/IL1B/NCF2/DDIT3/TUBA1C/PRNP/MAPK13/PSMA6/TUBB4B/ATF4/TUBA4A/PSMD7/PSMD12/HSPA5/MAPK1/MCU/MAPK14/CREB5/PSMD14/HSPA6/ITPR1/NOTCH1/TNF/PSMD1/MAPK8/GSK3B/TUBB6/CYCS/NDUFB9/PPP3R1/PRKCD/RAC2/PSMD11/IL6/SDHA/NCF1/HSPA8/PPP3CA/ATF2/PIK3CD/RAC1/NDUFV2/CASP9/PPP3CC/CASP3/APAF1	-0.0291529662027396
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/1711	27/9376	1.01478450981665	ELOVL5/ELOVL7/ACOX3/ACOX1/SCD	0.0363463492637053
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	9/1711	50/9376	0.986370543541788	SAT1/ARG1/SMS/P4HA1/P4HA2/AMD1/ALDH2/ALDH3A2/ODC1	-0.0456531129921283
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	8/1711	45/9376	0.974193129423989	ABCG1/ABCA1/TAP1/DEFB1/ABCC3/ABCC1/TAP2/ABCA13	-0.0819845598360308
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1711	91/9376	0.963487710419329	PDE4B/PDE7A/GNB1/PDE4A/PDE2A/PRKCB/ADCY3/GNAI3/GNG7/PDE8A/PDE1B/PDE3B/GNG5/GABRR2/GNGT2/PDE4C	-0.165357300100305
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	45/1711	254/9376	0.970837149155304	PTK2B/VEGFA/PPIF/ATP2B1/CXCR4/SPHK1/PLCG2/CAMK1D/P2RX4/ATP2A2/PRKCB/GNA15/ADORA2A/ATP2A3/ADCY3/MCU/ORAI2/STIM1/ITPR1/GNAL/P2RX7/NFATC1/TPCN2/P2RX1/GNAQ/PDE1B/PPP3R1/PTAFR/CD38/ITPKB/ADORA2B/SLC8A1/ITPKC/PLCB2/ASPH/TFEB/PPP3CA/ADRB2/CACNA1G/PPP3CC/HTR7/CAMK1/NTSR1/PHKA2/MET	-0.22261599454027
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/1711	86/9376	0.95578541040871	ITGA5/ITGAV/ITGB8/ATP2A2/ATP2A3/EMD/TCF7L2/LMNA/SNTB1/ITGA4/SLC8A1/TCF7/CTNNB1/ITGB1/DSC2	-0.194608376747618
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1711	17/9376	0.967029944648812	TXNRD1/SEPHS2/PAPSS2	-0.0642812001644284
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1711	17/9376	0.967029944648812	MYH9/LAMP2/TFRC	-0.0642812001644284
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	41/1711	233/9376	0.964263049242092	AMPD3/ITGA5/ITGAV/VIM/MYH9/DIAPH1/PLEC/ITGB8/FMNL1/ATP1B3/FMNL3/ATP1A1/SDC4/ZYX/EMD/TPM3/TLN1/TPM4/SUN2/LMNA/LBR/SNTB1/LMNB1/ENO1/PDLIM7/ITGA4/AMPD2/SDC2/CAPZA1/ACTG2/TMOD3/INF2/MYOM1/THBS1/ITGB1/AGRN/ENO3/DSC2/CSRP1/FHL3/TNNI2	-0.2609790571124
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/1711	29/9376	0.94479937120861	PAK1/LATS2/RASSF2/SAV1/MOB1A	-0.140657037394166
Organismal Systems	Digestive system	hsa04970	Salivary secretion	16/1711	93/9376	0.94276754460386	ATP2B1/SLC9A1/KCNMA1/PRKCB/ATP1B3/ADCY3/ATP1A1/ITPR1/CAMP/KCNN4/GNAQ/SLC12A2/CD38/PLCB2/BST1/ADRB2	-0.262056080376187
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	13/1711	76/9376	0.937340428804331	KCNJ15/SLC9A1/PRKCB/ATP1B3/ADCY3/EZR/ATP1A1/GNAI3/CA2/ITPR1/GNAQ/PLCB2/SSTR2	-0.259123799911803
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	9/1711	53/9376	0.930538248624329	ATP2B1/VDR/DNM2/PRKCB/ATP1B3/ATP1A1/GNAQ/SLC8A1/PLCB2	-0.239585419887196
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	17/1711	99/9376	0.940982000011807	ITGA5/ITGAV/TGFB1/ITGB8/PRKAG2/ATP2A2/ATP2A3/EMD/TPM3/TPM4/TNF/LMNA/SNTB1/ITGA4/SLC8A1/IL6/ITGB1	-0.278902797448578
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	10/1711	59/9376	0.928785822544057	ANPEP/GSTO1/GCLC/SMS/PGD/RRM1/GSTO2/ODC1/G6PD/GCLM	-0.259244161236875
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/1711	30/9376	0.913306058834989	OGDH/MDH2/ACLY/SDHA/DLST	-0.224693779336295
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1711	12/9376	0.913306058834989	COQ7/COQ2	-0.141972173323725
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	9/1711	54/9376	0.913306058834989	REV3L/ERCC1/BRCA2/HES1/TOP3A/WDR48/BLM/FANCD2/RPA2	-0.301846149889734
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	17/1711	101/9376	0.92234869308088	MAP2K1/CREBBP/EP300/RAF1/PRKCB/ADCY3/MAPK1/GNAI3/KRAS/GNAQ/TCF7L2/GSK3B/PLCB2/TCF7/NRAS/WNT2B/CTNNB1	-0.370686748300615
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	6/1711	37/9376	0.888622111298909	GLS/GLUL/IL4I1/GLUD1/ASL/GFPT1	-0.320703883362285
NA	NA	hsa04981	Folate transport and metabolism	5/1711	31/9376	0.883844573066119	FPGS/MTHFS/ABCC3/ABCC1/SLC19A1	-0.306044981841045
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	8/1711	49/9376	0.894667159675091	NFKB1/ATF4/GNAI3/CREB5/RELA/ATF2/SLC6A3/FOSB	-0.349257233990762
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	35/1711	205/9376	0.93558181636755	NFKB1/PPIF/PIK3R1/TGFB1/PIK3CB/NCF2/MMP9/SMAD3/ATP2A2/PRKCB/MAPK13/ATP2A3/PTEN/CTSD/MAPK14/MAPK8/RELA/GSK3B/NDUFB9/AKT3/PRKCD/PPP1CB/RAC2/GAPDH/PLCB2/TGFBR1/GYS1/SDHA/NCF1/PIK3CD/RAC1/NDUFV2/G6PD/GFPT1/INSR	-0.440586942761713
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	7/1711	44/9376	0.871792147069762	POLG2/POLE4/PARP4/POLG/TDP1/POLB/MBD4	-0.402724604578004
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	7/1711	44/9376	0.871792147069762	DYNC1H1/RAB5A/STX4/DYNC1LI1/ADCY3/CREB5/DCTN4	-0.402724604578004
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/1711	56/9376	0.880687985305168	B4GALT1/STT3B/MAN2A1/MAGT1/MGAT4A/MGAT1/DHRSX/ALG13/DPM1	-0.423082244760485
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	10/1711	63/9376	0.869815294128561	CDKN1A/GADD45B/PTCH2/GADD45A/TCF7L2/GSK3B/TCF7/WNT2B/CTNNB1/AXIN1	-0.489823934945319
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	11/1711	69/9376	0.873597099755207	PRKCB/ATF4/CREB5/SIRT1/PPP3R1/PPP1CB/PPP3CA/ATF2/SLC6A3/PPP3CC/FOSB	-0.497887577397734
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	8/1711	52/9376	0.843051746616913	PTGS2/ADCY3/ALOX5/PLA2G4A/LDLR/IGF1R/BMP6/INSR	-0.536181209123546
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	14/1711	89/9376	0.861996729686956	GLS/GABARAPL1/GLUL/GNB1/SLC38A2/SRC/PRKCB/ADCY3/GNAI3/GNG7/SLC38A1/GNG5/GABRR2/GNGT2	-0.618018139202642
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	25/1711	154/9376	0.889583823540574	KMO/GCH1/PPCDC/BCAT1/MTHFD2/PDXK/MAT2A/GCLC/KYNU/MTHFD2L/FPGS/MTHFD1L/CMPK2/UGP2/NADK/OXSM/AK2/AK4/ALDH2/COQ7/PTS/ALDH3A2/COQ2/ALPL/GCLM	-0.65273224737774
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	4/1711	28/9376	0.782833764715705	B3GNT5/B4GALT1/ST3GAL6/B3GNT2	-0.543709009891593
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	4/1711	28/9376	0.782833764715705	GCH1/FPGS/PTS/ALPL	-0.543709009891593
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	7/1711	47/9376	0.81614583980999	PKM/LDHA/ACAT2/MDH2/ALDH2/ALDH3A2/ACAT1	-0.596979485259913
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	3/1711	22/9376	0.747250411774082	ALDH2/ALDH3A2/ALDH3B1	-0.560735016720305
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1711	48/9376	0.799142801480616	BCAT1/IL4I1/HMGCS1/ACAT2/ALDH2/ALDH3A2/ACAT1	-0.659125804435802
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1711	16/9376	0.684979544126242	IL4I1/ALDH3B1	-0.595820423668785
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	6/1711	43/9376	0.764628328326968	ABCA1/ACAT2/APOA1/APOB/ACAT1/DGAT1	-0.730856897641066
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	16/1711	105/9376	0.835022682363419	ITGA5/ITGAV/TGFB1/ITGB8/ATP2A2/ATP2A3/ADCY3/EMD/TPM3/TPM4/TNF/LMNA/SNTB1/ITGA4/SLC8A1/ITGB1	-0.803174960334667
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	12/1711	82/9376	0.801927271172186	UPP1/GSTO1/TYMP/RRM1/DPYD/GSTO2/UCK2/CDADC1/UPB1/CDA/TPMT/MPO	-0.851108328566131
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	4/1711	31/9376	0.707075658452895	GLUL/ACAT2/MDH2/ACAT1	-0.771793683308605
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	4/1711	31/9376	0.707075658452895	SRP54/HSPA5/SEC63/BAG6	-0.771793683308605
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	7/1711	51/9376	0.752134401393521	LPCAT1/PAFAH1B1/PLA2G6/LPCAT2/PAFAH1B2/PLA2G4A/PLB1	-0.838554871318711
Organismal Systems	Digestive system	hsa04976	Bile secretion	13/1711	90/9376	0.791531917656991	AQP9/SLC9A1/ATP1B3/ADCY3/ATP1A1/RXRA/CA2/ABCC3/NCEH1/SLC22A1/LDLR/HMGCR/SLC10A1	-0.938860461458851
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	2/1711	18/9376	0.608870705889993	ZNF143/TCN1	-0.784728886603194
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	12/1711	86/9376	0.764628328326968	KCNMA1/PRKCB/ATP1B3/ADCY3/ATF4/ATP1A1/CREB5/KCNN4/GNAQ/KCNMB1/PLCB2/ATF2	-1.03597702432785
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1711	19/9376	0.576824879264204	OGDH/DLST	-0.872334755394995
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	3/1711	27/9376	0.608870705889993	HMGCS1/ACAT2/ACAT1	-0.961555175469822
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	36/1711	235/9376	0.83946429237599	MAP2K3/ACSL1/ACSL5/ACSL3/GRB2/MGLL/PRKAG2/ACSL4/RHEB/MAPK13/RPS6KA3/RPTOR/ZNF516/ADCY3/PPARG/SMARCA2/SOS2/MAPK14/KRAS/CREB5/CPT1A/NDUFB9/RPS6KA1/KDM3A/SMARCC1/ARID1A/KDM3B/SDHA/NRAS/PNPLA2/ATF2/NDUFAF2/SLC25A29/NDUFV2/SMARCD3/MAP3K5	-1.17750642834429
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	12/1711	88/9376	0.747250411774082	PLAUR/ITGAX/C5AR1/SERPINA1/CD55/THBD/C3/SERPINB2/PLAU/CD46/ITGB2/ITGAM	-1.12544753113308
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1711	28/9376	0.587125323536779	ELOVL5/ELOVL7/PPT1	-1.03369513799075
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	8/1711	63/9376	0.695852235302849	PTGS2/PLA2G6/CYP4F3/ALOX5/PLA2G4A/LTA4H/PLB1/TBXAS1	-1.14436526096931
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	13/1711	97/9376	0.734411057619888	GNB1/PRKCB/ADCY3/MAPK1/GNAI3/ITPR1/GNG7/GNAQ/PER1/PLCB2/CACNA1G/GNG5/GNGT2	-1.242223762635
Organismal Systems	Sensory system	hsa04744	Phototransduction	3/1711	29/9376	0.566879622725166	GNB1/SLC24A1/PDE6A	-1.10363650625703
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1711	13/9376	0.421525873308457	PRKDC	-0.986058467771388
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	21/1711	149/9376	0.772325928947709	PTGS2/GNB1/MGLL/PRKCB/MAPK13/ADCY3/MAPK1/GNAI3/MAPK14/ITPR1/GNG7/GNAQ/MAPK8/NDUFB9/PLCB2/DAGLB/ABHD6/NDUFV2/GNG5/GABRR2/GNGT2	-1.3235215302461
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	20/1711	143/9376	0.766410678742648	HLA-DRB5/HLA-DQA1/C3/HLA-DPB1/HLA-DRB1/ACTN1/HLA-DQA2/HLA-DQB1/IL10/HLA-DRA/HLA-DMB/HLA-DMA/HLA-DPA1/CD80/HLA-DOA/FCGR3B/TNF/RO60/SNRPB/HLA-DQB2	-1.32985456693764
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	47/1711	308/9376	0.83620879412814	SOD2/PPIF/ERN1/DNAH17/RCOR1/RB1CC1/CREBBP/EP300/TUBA1C/PSMA6/TUBB4B/PPARG/TUBA4A/PSMD7/PSMD12/ATG2A/TAF4B/CREB5/PSMD14/SIN3A/ITPR1/PSMD1/NRF1/GNAQ/MAPK8/SLC1A3/TUBB6/CYCS/POLR2A/NDUFB9/DCTN4/BECN1/NRBF2/ACTR1A/PSMD11/DNAI2/PLCB2/SDHA/WIPI1/HIP1/NDUFV2/CASP9/CASP8/CASP3/ATG13/MAP3K5/APAF1	-1.38090800187739
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/1711	30/9376	0.547983635300994	PLA2G6/PLA2G4A/PLB1	-1.1715382175642
NA	NA	hsa04519	Cadherin signaling	63/1711	404/9376	0.854528936236698	NFKBIA/NFKB1/PTK2B/MAP2K3/VIM/MAP2K1/LHFPL2/ERBIN/ACTR3/VAV1/CREBBP/PSEN1/LATS2/ACTN1/EP300/VASP/CSNK1A1/SHOC2/YWHAZ/RAF1/MRAS/YWHAG/MAPK13/ROCK1/MAPK1/MAPK14/KRAS/MYO1F/CYFIP2/YWHAH/CDH23/MYO1G/SAV1/MAPK8/TCF7L2/RELA/MOB1A/GSK3B/TAOK3/TAOK1/PPP1CB/RAC2/RHOA/YWHAQ/APH1B/TCF7/ACTR2/NRAS/VAV2/CDC42/WNT2B/CHUK/CTNNB1/AXIN1/IGF1R/RAC1/DSC2/GABRR2/VAV3/IKBKG/ARPC2/ARPC5/MET	-1.41213828700117
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	3/1711	32/9376	0.513734658094681	LDHA/ACOX3/ACOX1	-1.3017765812858
Genetic Information Processing	Transcription	hsa03040	Spliceosome	35/1711	243/9376	0.789276840968509	HNRNPC/DDX5/FUS/HNRNPM/RBM22/CTNNBL1/SNIP1/SF3B1/PRPF40A/PRPF38B/HSPA6/CWC25/SNRPB/SRSF5/SRSF2/TRA2A/EIF4A3/RBM8A/PRPF3/PCBP1/SNW1/HNRNPU/SRSF4/SLU7/HNRNPA3/SF1/DHX8/SRSF3/PRPF38A/HSPA8/SF3A1/BCAS2/RBM25/RBMXL1/CASC3	-1.57240074056767
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/1711	33/9376	0.498166941182721	BCAT1/OGDH/DLST	-1.36435575285968
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/1711	34/9376	0.483514972324406	POLR2A/CRCP/POLR3E	-1.42538382681614
Human Diseases	Substance dependence	hsa05034	Alcoholism	26/1711	191/9376	0.745946309833813	BRAF/MAP2K1/GRB2/GNB1/CAMKK2/RAF1/ADORA2A/ATF4/SOS2/MAPK1/GNAI3/CAMKK1/KRAS/CREB5/GNG7/HDAC4/ADORA2B/PPP1CB/HDAC5/NRAS/ATF2/SLC6A3/ARAF/GNG5/FOSB/GNGT2	-1.67593501294774
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	10/1711	87/9376	0.629866247472406	SLC9A1/ATP2A2/ATP1B3/ATP2A3/SLC9A7/ATP1A1/TPM3/TPM4/SLC8A1/ASPH	-1.63865828648332
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	3/1711	36/9376	0.456653029417495	POLE4/RPA2/RNASEH1	-1.54315526758102
Cellular Processes	Cell motility	hsa04814	Motor proteins	26/1711	194/9376	0.734411057619888	MYO9B/DNAH17/MYH9/DYNC1H1/KIF13B/TUBA1C/TUBB4B/DYNC1LI1/TUBA4A/KIF1B/TPM3/MYO1F/TPM4/MYO1G/KIFC3/TUBB6/DCTN4/ACTR1A/CAPZA1/HOOK3/DNAI2/ACTG2/KIF13A/KIF21B/CENPE/TNNI2	-1.76602470087256
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	10/1711	89/9376	0.615711949776397	CD44/ITGA5/ITGAV/ITGB8/LAMB3/SDC4/ITGA4/THBS1/ITGB1/AGRN	-1.72095186714249
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/1711	37/9376	0.444311055649454	IL4I1/ALDH3B1/FAH	-1.60006267377703
NA	NA	hsa04081	Hormone signaling	29/1711	219/9376	0.725640430307252	ITGAV/IRS2/GNA13/PIK3R1/PIK3CB/ADIPOR2/GNA12/GNB1/SRC/STAT3/GNA15/STAT5B/ADCY3/GNAI3/GNG7/GNAQ/STAT5A/ADRA2B/HAMP/RHOA/ACVR1/PLCB2/ADRB2/IGF1R/PIK3CD/GNG5/GNGT2/INSR/SSTR2	-1.94097582717714
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	2/1711	31/9376	0.353537829226447	ALDH2/ALDH3A2	-1.70329108624372
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	8/1711	83/9376	0.528176997880476	SOD2/ACSL1/ACSL5/ACSL3/ACSL4/ACOX3/ACOX1/PEX14	-2.0398336442559
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/1711	23/9376	0.238253754478693	B4GALT1	-1.72803819128696
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1711	23/9376	0.238253754478693	RPA2	-1.72803819128696
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/1711	36/9376	0.304435352944996	FGGY/UGP2	-1.97546744006936
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/1711	138/9376	0.595634386196732	ATP6V1H/ATP6V0D1/ATP6V1B2/TCIRG1/ATP6V1E1/CYCS/NDUFB9/ATP6V1F/ATP6V1A/ATP6V1C1/ATP6V1D/SDHA/ATP6V0B/NDUFV2/ATP6V0C	-2.26088954129179
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1711	26/9376	0.210762936654228	HES1	-1.90389460787559
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	2/1711	41/9376	0.267309090390729	SDS/SDSL	-2.22131492141036
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	9/1711	103/9376	0.478820652204752	SLC38A2/SLC36A4/SLC3A2/ATP1B3/ATP1A1/KCNN4/SLC8A1/COL23A1/MME	-2.51275556738155
NA	NA	hsa04082	Neuroactive ligand signaling	22/1711	199/9376	0.605811054101601	P2RX4/GNB1/PRKCB/ADORA2A/ADCY3/GNAI3/GNAL/P2RX1/GNG7/GNAQ/ADRA2B/SLC1A3/ADORA2B/OGFR/PLCB2/ADRB2/SLC6A3/HTR7/GNG5/P2RY6/GABRR2/GNGT2	-2.65543195439384
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/1711	46/9376	0.238253754478693	FTH1/HMOX1	-2.446825397346
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1711	68/9376	0.322343314882937	ALDH1A2/DHRS9/CYP2S1/DGAT1	-2.64966250071844
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/1711	41/9376	0.133654545195364	GABRR2	-2.62651830480582
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3/1711	66/9376	0.249083470591361	DHRS9/HSD17B11/SRD5A1	-2.89230011543569
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4/1711	79/9376	0.277460068506832	GSTO1/GSTO2/ALDH3B1/CYP2S1	-3.04690242959679
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	3/1711	70/9376	0.234850129414712	PTGS2/GSTO1/GSTO2	-3.03576792767923
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3/1711	73/9376	0.225198754233285	GSTO1/GSTO2/ALDH3B1	-3.1397480059188
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/1711	183/9376	0.359333531344914	NXF1/GTPBP4/TCOF1/NXT1/XRN2/GNL2/GAR1/EFL1/REXO1/RIOK1/GNL3L/NXT2	-4.13507577677916
Organismal Systems	Sensory system	hsa04742	Taste transduction	2/1711	86/9376	0.127438054721161	PDE1B/PLCB2	-3.84053918292863
NA	NA	hsa04382	Cornified envelope formation	15/1711	217/9376	0.378790531314051	ST14/PPP2R2A/PPP2CA/PLEC/LAMB3/UGCG/PPP2R2D/PPP2R5C/ABHD5/KDSR/PPP2R5A/PPP2R3C/TGM3/PADI2/S100A9	-4.37419830098867
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	27/1711	370/9376	0.399879950084509	C5AR1/FPR3/C3/NR3C1/FPR1/P2RX4/ADM/PTGER4/P2RY8/ADORA2A/P2RX7/P2RX1/ADRA2B/CHRNE/PTAFR/ADORA2B/PTGER2/OGFR/S1PR3/ADRB2/HTR7/P2RY6/GABRR2/NTSR1/GPR35/SSTR2/FPR2	-5.56451850244956
Genetic Information Processing	Translation	hsa03010	Ribosome	2/1711	222/9376	0.0493678950721616	RPS26/RPS4Y1	-6.77232940302607
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	8/1711	449/9376	0.0976362824589743	RGS2/GNB1/PDE2A/ADCY3/GNAL/GNG7/PDE1B/SLC8A1	-9.25777435485443