category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	37/937	82/9376	4.51508446781373	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/CD74/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/HLA-DOA/IFI30/HLA-DMA/CIITA/CTSB/HSP90AA1/HSPA6/HLA-DQB2/HSPA1A/HSPA1B/B2M/HSP90AB1/HLA-E/HLA-DMB/CTSS/HSPA1L/HLA-C/HSPA8/HLA-G/TAP1/HLA-F/HSPA5/TAPBP/TAP2/HSPA4/KLRD1	10.6524939922434
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	56/937	180/9376	3.11310328471481	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/CD74/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/NFKBIA/HLA-DOA/ITGA5/HLA-DMA/IL1B/AKT3/HLA-DQB2/BCL2/C3/SRC/BIRC3/OAS2/B2M/PILRA/HLA-E/IL6/HLA-DMB/NFKB1/STAT1/TRAF3/ZC3HAV1/TICAM1/NXF1/IRF7/CGAS/TNFSF14/HLA-C/HLA-G/OAS3/EIF2AK2/TAP1/HLA-F/ITGB3/IFIH1/NECTIN2/JAK2/PIK3CB/TAPBP/CASP8/RHEB/TAP2/JAK1/BID/CFP/IRAK1	9.53822222491874
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	58/937	205/9376	2.83107999062915	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/VIM/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/NFKBIA/HLA-DOA/HLA-DMA/TNFAIP3/CD44/CDKN1A/HES1/AKT3/HLA-DQB2/BCL2/OAS2/B2M/HLA-E/IL6/HLA-DMB/NFKB1/STAT1/ISG15/TRAF3/CD58/RUNX3/JUN/IRF7/RELB/GADD45G/HLA-C/NCOR2/GADD45B/HLA-G/MAP2K3/OAS3/EIF2AK2/GADD45A/NFKBIE/TAP1/HLA-F/NFKB2/PIK3CB/TAPBP/CASP8/MDM2/NEDD4/TAP2/JAK1/BID/IRAK1/CCND3	8.83254463594599
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	39/937	112/9376	3.4843726177771	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/NFKBIA/HLA-DOA/HLA-DMA/CIITA/HSPA6/AKT3/HLA-DQB2/BCL2/HSPA1A/HSPA1B/LDLR/BIRC3/HLA-DMB/NFKB1/STAT1/LAMB3/PPIF/LAMB1/HSPA1L/HSPA8/MAP2K3/LAMA3/IL10/CCR5/JAK2/CASP8/PIK3R5/JAK1/SOCS1/PIK3R6/IRAK1	8.81325654629589
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	23/937	45/9376	5.11438396774576	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/HLA-DOA/HLA-DMA/IL1B/CD80/HLA-DQB2/HLA-E/IL6/IL1A/HLA-DMB/HLA-C/HLA-G/HLA-F/KLRD1	9.21842913351577
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	35/937	100/9376	3.50224119530416	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/HLA-DOA/ITGA5/HLA-DMA/CD44/IL3RA/IL1B/CD22/HLA-DQB2/CSF3/IL1R2/IL6/IL1A/HLA-DMB/CD38/TFRC/CSF3R/IL1R1/CD9/ANPEP/IL7/IL7R/IL6R/ITGB3/IL2RA/CSF2RA/ITGA4/MME	8.38221391692099
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	50/937	181/9376	2.76419983844054	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/CD74/HLA-DPB1/HLA-DPA1/ITGAX/HLA-DQA2/FCGR2B/HLA-DOA/HLA-DMA/CIITA/SPHK1/IL1B/AKT3/HLA-DQB2/BCL2/C3/SRC/VDR/PLK3/IL6/IL1A/CTSD/HLA-DMB/NFKB1/RAB7A/STAT1/IL18/CTSS/CEBPB/CLEC4E/LSP1/HSPD1/NOD2/MALT1/IRAK2/IL10/BCL10/IL23A/JAK2/RIPK2/CASP8/MRC2/JAK1/BID/ATP6V1H/IRAK1	7.98584982227124
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	22/937	44/9376	5.00320170757737	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/HLA-DOA/HLA-DMA/IL1B/CD80/HLA-DQB2/HLA-E/IL1A/HLA-DMB/HSPD1/HLA-C/HLA-G/HLA-F	8.86862694043124
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	27/937	66/9376	4.09352866983603	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/HLA-DOA/STAT4/HLA-DMA/IL1B/HLA-DQB2/IL6/IL1A/HLA-DMB/NFKB1/STAT1/IL18/NFATC1/JUN/NOD2/IL10/IL23A/IL2RG/SMAD3/RORA	8.4035195113974
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	33/937	95/9376	3.47590855473797	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/VEGFA/HLA-DOA/HLA-DMA/CXCL2/CXCL3/IL1B/CD80/HLA-DQB2/CCL20/IL15/IL6/IL1A/HLA-DMB/IL18/CXCL12/ACP5/JUN/TNFSF13/CCL3L1/TNFSF13B/FLT1/CXCL1/IL23A/ATP6V1A/ATP6V1H	8.08181596919938
Human Diseases	Immune disease	hsa05330	Allograft rejection	20/937	39/9376	5.13148893084859	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/HLA-DOA/HLA-DMA/CD80/HLA-DQB2/HLA-E/HLA-DMB/HLA-C/HLA-G/IL10/HLA-F	8.61479917591469
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	35/937	109/9376	3.21306531679281	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/NFKBIA/HLA-DOA/HLA-DMA/HSP90AA1/IL1B/AHR/HLA-DQB2/HSP90AB1/IL6/IL1RAP/HLA-DMB/IRF4/NFKB1/STAT1/NFATC1/RARA/JUN/IL1R1/NFKBIE/IL6R/IL2RA/IL23A/JAK2/IL2RG/SMAD3/RORA/JAK1	7.74368787650263
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	22/937	50/9376	4.40281750266809	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/CXCR4/HLA-DQA2/HLA-DOA/HLA-DMA/CD80/HLA-DQB2/IL15/IL6/HLA-DMB/CXCL12/TNFSF13/TNFSF13B/IL10/ICOSLG/ITGA4	8.03870135957244
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	42/937	155/9376	2.7114125383	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/FCGR2B/HLA-DOA/ITGA5/HLA-DMA/THBS1/OLR1/TUBB6/MSR1/HLA-DQB2/C3/RAB7B/HLA-E/HLA-DMB/TUBB4B/RAB7A/CTSS/TFRC/DYNC1H1/TUBB3/HLA-C/HLA-G/TAP1/HLA-F/ITGB3/THBS2/TUBA4A/TUBA1C/MRC2/ITGAV/ATP6V1A/TAP2/ATP6V1H	7.15882074125318
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	26/937	78/9376	3.33546780505158	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/NFKBIA/HLA-DOA/HLA-DMA/IL1B/PTGS2/HLA-DQB2/C3/IL1A/HLA-DMB/NFKB1/STAT1/MARCKSL1/JUN/IL10/JAK2/ITGA4/JAK1/IRAK1	6.90138658670471
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	24/937	70/9376	3.43076688519591	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/HLA-DOA/HLA-DMA/CD80/HLA-DQB2/HLA-E/HLA-DMB/ABL2/HLA-C/SNTB1/HLA-G/HLA-F/CASP8/FYN/BID	6.80175128517774
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	42/937	173/9376	2.42930025107803	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/NFKBIA/HLA-DOA/HLA-DMA/CIITA/DNAJB1/IL1B/MX2/AKT3/HLA-DQB2/OAS2/MX1/IL6/IL1A/HLA-DMB/NFKB1/STAT1/IL18/TRAF3/TICAM1/NXF1/MAP2K1/IRF7/TNFRSF10A/OAS3/EIF2AK2/IFIH1/JAK2/PIK3CB/CASP8/ADAR/JAK1/BID/CCND3/NUP98	6.32254240404302
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	30/937	105/9376	2.85897240432993	CCL21/NFKBIA/TRAF1/TNFAIP3/CXCL2/CXCL3/IL1B/PTGS2/BCL2/BIRC3/PLAU/NFKB1/TRAF3/TICAM1/CXCL12/RELB/IL1R1/GADD45G/TNFSF14/GADD45B/MALT1/TNFSF13B/CXCL1/GADD45A/BCL10/NFKB2/PPP1R13L/CARD11/CFLAR/IRAK1	6.38284417517464
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	39/937	160/9376	2.43906083244397	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/CADM1/HLA-DOA/HLA-DMA/CD80/CD22/HLA-DQB2/SDC4/ALCAM/SDC2/HLA-E/JAML/HLA-DMB/ITGB8/CD58/VSIR/HLA-C/CLDN1/HLA-G/CD274/HLA-F/ICOSLG/NECTIN2/SDC3/CD226/ITGA4/SELL/ITGAV/NRXN3/F11R	6.11755456158595
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	20/937	54/9376	3.7060753389462	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/HLA-DOA/HLA-DMA/CD80/HLA-DQB2/HLA-E/HLA-DMB/HLA-C/HLA-G/IL10/HLA-F	6.64495668414175
Human Diseases	Infectious disease: viral	hsa05162	Measles	35/937	136/9376	2.57517734948835	FCGR2B/NFKBIA/TNFAIP3/HSPA6/IL1B/MX2/AKT3/BCL2/HSPA1A/HSPA1B/OAS2/MX1/IL6/IL1A/NFKB1/STAT1/TRAF3/JUN/IRF7/HSPA1L/HSPA8/OAS3/EIF2AK2/IL2RA/IFIH1/MSN/IL2RG/PIK3CB/CASP8/SLAMF1/ADAR/JAK1/BID/IRAK1/CCND3	6.16556480572222
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	32/937	119/9376	2.6907975570164	NFKBIA/TRAF1/TNFAIP3/CXCL2/CXCL3/IL1B/PTGS2/AKT3/CCL20/CREB5/BIRC3/IL15/IL6/NFKB1/IRF1/TRAF3/ADAM17/CEBPB/JUN/MAP2K1/NOD2/MMP9/JUNB/MAP2K3/CXCL1/LIF/PIK3CB/CASP8/BCL3/MLKL/FRMD8/CFLAR	6.185002801671
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	47/937	216/9376	2.17731926163089	SOD2/NFKBIA/OLR1/CXCL2/CXCL3/ERN1/HSP90AA1/HSPA6/IL1B/APOA1/AKT3/BCL2/HSPA1A/SRC/APOB/HSPA1B/LDLR/HSP90AB1/IL6/ITPR1/NFKB1/EIF2AK3/IL18/NFATC1/TRAF3/TICAM1/DDIT3/JUN/IRF7/HSPA1L/HSPD1/TNFRSF10A/HSPA8/ERO1A/CCL3L1/MMP9/MAP2K3/CXCL1/NFE2L2/HSPA5/JAK2/PIK3CB/CASP8/TANK/HSPA4/BID/IRAK1	5.83288384872117
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	45/937	203/9376	2.21816824473874	VEGFA/ITGA5/THBS1/FLNA/EMP1/MYL9/DIAPH1/AKT3/ACTN1/VWF/BCL2/EMP2/SRC/CAPN2/BIRC3/TNC/RAPGEF1/LAMB3/PDGFD/ITGB8/PRKCG/SHC3/PDGFB/LAMB1/PAK1/JUN/MAP2K1/FLT1/LAMA3/FLT4/ITGB3/THBS2/ITGA11/RELN/VCL/PARVB/RASGRF1/PIK3CB/ITGA4/FLNB/FYN/ITGAV/FN1/PDGFA/CCND3	5.84668285124138
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	29/937	105/9376	2.7636733241856	NFKBIA/MRAS/IL1B/PTGS2/AKT3/SRC/PLK3/IL6/ITPR1/NFKB1/STAT1/NFATC1/IRF1/CLEC4E/PAK1/JUN/RELB/LSP1/MALT1/IL10/BCL10/IL23A/NFKB2/MAPKAPK2/PIK3CB/CASP8/BCL3/MDM2/EGR3	6.05563158332447
NA	NA	hsa04518	Integrin signaling	37/937	154/9376	2.40413588545926	ITGAX/VEGFA/ITGA5/THBS1/FLNA/ITGAD/AKT3/ACTN1/VWF/C3/SRC/LIMS1/TNC/LAMB3/PDGFD/ITGB8/PDGFB/LAMB1/FLT1/LAMA3/FLT4/ITGB3/THBS2/ITGA11/RELN/VCL/FBN1/PARVB/FERMT2/PIK3CB/ITGA4/FLNB/ITGAV/FN1/PDGFA/LIMS2/CCND3	5.85419090175273
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	58/937	298/9376	1.94755502711066	CXCR4/CCL21/IL1RL1/CXCL2/CXCL3/IL3RA/IL1B/INHBA/CSF3/CCL20/CCL14/CCL18/IL1R2/IL15/IL6/IL1RAP/IL1A/IL18/TNFRSF10D/CLCF1/CXCL12/CCR7/CSF3R/TNFRSF12A/IL1R1/TNFSF13/TNFSF14/TNFRSF10A/CCL3L1/TNFSF13B/TNFRSF9/IL1RL2/CXCL1/IL7/CXCL16/IL7R/IL1RN/IL10/IL6R/CCR5/IL2RA/IL23A/OSM/IL19/CSH2/LIF/CSF2RA/IL2RG/PRLR/BMP8A/RELT/CRLF2/BMP2/IL32/BMP6/CXCL13/ACVR1B/CD70	5.53894972298767
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	37/937	157/9376	2.35819698318934	SERPINE1/HLA-B/HLA-A/CDKN1A/FOXO1/MRAS/AKT3/ZFP36L2/CAPN2/HLA-E/IL6/ITPR1/IL1A/NFKB1/NFATC1/HIPK2/RASSF5/MAP2K1/IGFBP3/GADD45G/HLA-C/HIPK4/GADD45B/HLA-G/MAP2K3/GADD45A/HLA-F/MAPKAPK2/SMAD3/PIK3CB/SQSTM1/MDM2/LIN54/RHEB/FOXO3/NBN/CCND3	5.71848018261494
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	48/937	233/9376	2.06140499539669	VIM/LMNA/ITGA5/ACTG2/DES/THBS1/AMPD3/MYL9/DIAPH1/MYH11/CSRP1/SDC4/TPM2/TTN/SDC2/FLNC/PLEC/ITGB8/PDLIM1/PDLIM4/JUP/PDLIM3/SNTB1/INF2/SUN2/NID1/MYH9/FMNL2/ITGB3/THBS2/ITGA11/SYNPO2/FBN2/COL11A1/VCL/FBN1/SDC3/FMNL3/ENO2/ITGA4/ATP1A1/AMPD2/ENO1/ITGAV/EMD/SYNE2/FN1/LMOD1	5.46669278275087
Human Diseases	Immune disease	hsa05310	Asthma	14/937	32/9376	4.3778014941302	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/HLA-DOA/HLA-DMA/HLA-DQB2/HLA-DMB/IL10/PRG2	6.37753187566278
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	47/937	227/9376	2.07181039873248	HLA-B/HLA-A/CXCR4/VEGFA/NFKBIA/CDKN1A/IL1B/PTGS2/AKT3/SRC/CREB5/B2M/PTK2B/HLA-E/IL6/ITPR1/NFKB1/NFATC1/PRKCG/CXCL12/AKAP13/MAP2K1/CGAS/IL1R1/HLA-C/CCL3L1/HLA-G/ADCY3/GNG4/TAP1/HLA-F/IL6R/ITGB3/CCR5/PTGER2/GNGT2/PIK3CB/TAPBP/CASP8/PTGER3/MDM2/ITGAV/RHEB/TAP2/JAK1/GNA12/BID	5.44695793358456
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	16/937	42/9376	3.81196320577324	FTH1/SAT1/TF/SLC7A11/HMOX1/TFRC/ACSL4/SLC39A14/ACSL5/ACSL1/STEAP3/CP/GCLC/GCLM/MAP1LC3B/FTL	6.08569693397536
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	42/937	196/9376	2.14422930324745	HLA-B/HLA-A/VEGFA/NFKBIA/CDKN1A/UBC/CXCL2/CXCL3/ZFP36/PTGS2/AKT3/C3/SRC/HLA-E/IL6/ITPR1/NFKB1/STAT1/NFATC1/TRAF3/TICAM1/PDGFB/JUN/MAP2K1/IRF7/HLA-C/HLA-G/CXCL1/GNG4/EIF2AK2/HLA-F/CCR5/MAPKAPK2/GNGT2/JAK2/PIK3CB/CASP8/PIK3R5/MAP1LC3B/JAK1/BID/PIK3R6	5.39423299251753
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	65/937	362/9376	1.79672989498635	VEGFA/ITGA5/THBS1/CDKN1A/NR4A1/EREG/IL3RA/HSP90AA1/AKT3/SGK1/VWF/BCL2/CSF3/MCL1/CREB5/TNC/HSP90AB1/IL6/DDIT4/NFKB1/LAMB3/PDGFD/ITGB8/CSF3R/PDGFB/LAMB1/MAP2K1/GYS1/FLT1/GNG4/LAMA3/IL7/IL7R/FLT4/IL6R/ITGB3/IL2RA/IGF2/OSM/CSH2/THBS2/ITGA11/RELN/GNGT2/JAK2/IL2RG/INSR/LPAR1/PIK3CB/YWHAH/ITGA4/YWHAG/EIF4E/PIK3R5/PRLR/MDM2/ITGAV/EFNA2/RHEB/FOXO3/JAK1/FN1/PDGFA/PIK3R6/CCND3	5.1512966643233
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	56/937	300/9376	1.86786197082889	VEGFA/FLNA/MRAS/NR4A1/EREG/DUSP2/HSPA6/IL1B/AKT3/HSPA1A/HSPA1B/DUSP1/JUND/PLA2G4C/DUSP5/IL1RAP/IL1A/NFKB1/PTPN7/PDGFD/NFATC1/PRKCG/DUSP16/DDIT3/DUSP8/PDGFB/DUSP10/HSPB1/PAK1/JUN/MAP2K1/HSPA1L/RELB/IL1R1/GADD45G/HSPA8/GADD45B/MAP2K3/FLT1/DUSP4/GADD45A/MAP3K21/FLT4/IGF2/NFKB2/MAPKAPK2/RASGRF1/INSR/RPS6KA3/TAOK3/EFNA2/CACNB2/PDGFA/GNA12/RASGRP2/IRAK1	5.09065871420277
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	33/937	142/9376	2.32543177957822	FCGR2B/NFKBIA/FOSL1/TREM2/FOSB/IL1B/AKT3/JUND/ITPR1/IL1A/NFKB1/STAT1/NFATC1/ACP5/JUN/MAP2K1/RELB/IL1R1/LILRA6/LILRB4/OSCAR/JUNB/LILRB2/LILRA5/ITGB3/NFKB2/ATP2A2/PIK3CB/SQSTM1/FYN/LILRB1/JAK1/SOCS1	5.30293808680303
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	45/937	224/9376	2.01021497179448	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-B/HLA-A/HLA-DQA2/NFKBIA/HLA-DOA/HLA-DMA/CDKN1A/FOSL1/ZFP36/AKT3/HLA-DQB2/CREB5/B2M/HLA-E/IL1R2/IL15/IL6/HLA-DMB/NFKB1/NFATC1/ETS2/JUN/MAP2K1/RELB/IL1R1/HLA-C/HLA-G/ADCY3/HLA-F/IL2RA/NFKB2/EGR1/IL2RG/SMAD3/PIK3CB/ESPL1/JAK1/CCND3	5.09905556191494
Organismal Systems	Digestive system	hsa04978	Mineral absorption	19/937	61/9376	3.11674860472033	MT1M/MT1G/FTH1/MT1H/MT1X/MT2A/MT1A/MT1E/SLC30A1/TF/MT1F/VDR/HMOX1/SLC8A2/SLC31A1/ATP1A1/SLC8A1/FTL/ATP2B1	5.52653227009153
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	18/937	56/9376	3.21634395487117	NFKBIA/CXCL2/CXCL3/HSPA6/IL1B/C3/HSPA1A/HSPA1B/IL6/NFKB1/IL18/HSPA1L/HSPD1/HSPA8/CXCL1/BCL2L13/NFKB2/CASP8	5.54285039745888
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	27/937	110/9376	2.45611720190162	SERPINE1/VEGFA/CDKN1A/TIMP1/TF/AKT3/HK2/BCL2/PFKFB3/IL6/NFKB1/ALDOB/PRKCG/HMOX1/TFRC/GAPDH/MAP2K1/EGLN3/FLT1/IL6R/ALDOC/LDHA/INSR/ENO2/PIK3CB/EIF4E/ENO1	5.11866217116604
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	24/937	93/9376	2.58229765552381	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/NFKBIA/HLA-DOA/STAT4/HLA-DMA/HLA-DQB2/HLA-DMB/NFKB1/STAT1/NFATC1/RUNX3/JUN/NFKBIE/IL2RA/JAK2/IL2RG/JAK1	5.10970024941346
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	31/937	137/9376	2.26422267058246	LMNA/NFKBIA/TRAF1/CTSB/IL3RA/ERN1/AKT3/BCL2/MCL1/CAPN2/BIRC3/CTSH/ITPR1/CTSD/NFKB1/EIF2AK3/CTSS/DDIT3/JUN/MAP2K1/GADD45G/TNFRSF10A/GADD45B/CTSZ/GADD45A/TUBA4A/PIK3CB/TUBA1C/CASP8/CFLAR/BID	4.96685308605239
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	23/937	88/9376	2.61530998350635	SERPINE1/ITGAX/C1QB/VWF/C3/SERPING1/C5AR1/THBD/CFH/PLAU/CLU/SERPINB2/PLAUR/SERPINA1/C1QA/SERPINC1/TFPI/C1S/PLAT/C1QC/KNG1/SERPINE2/C7	5.07278025981626
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	38/937	187/9376	2.03338679024535	NFKBIA/TNFAIP3/CTSB/CXCL2/CXCL3/HSP90AA1/IL1B/BCL2/GBP4/BIRC3/OAS2/GBP1/HSP90AB1/GBP2/IL6/ITPR1/GBP5/NFKB1/STAT1/IL18/TRAF3/TICAM1/TXNIP/JUN/IRF7/NAMPT/GABARAPL1/NOD2/OAS3/CXCL1/AIM2/RIPK2/TRIP6/CASP8/TANK/MAP1LC3B/JAK1/P2RX7	4.75619359115689
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	33/937	157/9376	2.10325676879049	THBS1/AXL/SPHK1/MFGE8/C1QB/DUSP2/PTGS2/SGK1/RAB7B/GPR132/DUSP5/RAB7A/NFATC1/SIGLEC10/DUSP16/ADAM17/DUSP8/CEBPB/SLC16A1/MAP2K1/C1QA/PPARD/DUSP4/IL10/ITGB3/MAPKAPK2/HAVCR1/PTGER2/C1QC/ATP2A2/JAK2/XKR6/ITGAV	4.6450934928816
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	23/937	94/9376	2.44837530370808	NFKBIA/TNFAIP3/FOSL1/CXCL2/CXCL3/FOSB/HSP90AA1/IL1B/PTGS2/CSF3/CCL20/HSP90AB1/JUND/IL6/NFKB1/MAPK6/TRAF3/CEBPB/JUN/MMP9/CXCL1/S100A8/CASP8	4.7025583820167
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	30/937	142/9376	2.11402889052565	VEGFA/HSP90AA1/IL1B/AKT3/BCL2/SDC4/SRC/DUSP1/THBD/HSP90AB1/SDC2/IL1R2/IL1A/NFKB1/HMOX1/GSTO2/PDGFB/JUN/IL1R1/MGST1/MMP9/ITGB3/NFE2L2/PLAT/PIK3CB/SQSTM1/NQO1/ITGAV/GSTM3/PDGFA	4.45713338429786
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	23/937	99/9376	2.32471998533898	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/FPR3/FCGR2B/HLA-DOA/HLA-DMA/C1QB/HLA-DQB2/C3/C5AR1/CFH/HLA-DMB/C1QA/C1S/IL10/DEFB1/C1QC	4.41517424330776
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	23/937	100/9376	2.30147278548559	CXCR4/CCL21/CXCL2/CXCL3/CCL20/CCL14/CCL18/IL6/IL18/TNFRSF10D/CXCL12/CCR7/TNFSF14/TNFRSF10A/CCL3L1/CXCL1/IL10/IL6R/CCR5/IL2RA/IL19/IL2RG/CXCL13	4.35978086983145
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	33/937	168/9376	1.96554352797683	STAT4/CDKN1A/IL3RA/AKT3/BCL2/CSF3/MCL1/IL15/IL6/STAT1/CLCF1/CSF3R/PDGFB/IL7/IL7R/IL10/IL6R/IL2RA/IL23A/OSM/IL19/CSH2/LIF/CSF2RA/JAK2/IL2RG/PIK3CB/PRLR/CRLF2/JAK1/SOCS1/PDGFA/CCND3	4.20778734251152
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	41/937	232/9376	1.76837301733338	ITGAX/CXCR4/ITGA5/MRAS/RGCC/ITGAD/MYL9/DIAPH1/MYH11/AKT3/ACTN1/SRC/TIAM1/EZR/IQGAP2/PDGFD/ITGB8/CXCL12/PDGFB/PAK1/MAP2K1/MYH9/ITGB3/SLC9A1/ITGA11/SSH1/KNG1/MSN/VCL/LPAR1/PIK3CB/ITGA4/C7/GSN/ITGAV/SPATA13/ACTR3C/FN1/PDGFA/GNA12/APC2	3.94873445706227
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	19/937	80/9376	2.37652081109925	VEGFA/AXL/AKT3/BCL2/SRC/IL6/PDGFD/PRKCG/SHC3/PDGFB/MAP2K1/IL6R/JAK2/PIK3CB/EIF4E/NRG2/FOXO3/JAK1/PDGFA	4.11992829913935
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	53/937	333/9376	1.59261075376337	HLA-B/HLA-A/VEGFA/ITGA5/THBS1/CDKN1A/HES4/FOXO1/PTGS2/HES1/MX2/AKT3/VWF/CREB5/TNC/MX1/OASL/HLA-E/PKM/NFKB1/STAT1/ISG15/LAMB3/IRF1/ITGB8/TRAF3/TICAM1/LAMB1/MAP2K1/HLA-C/HLA-G/EIF2AK2/LAMA3/LFNG/HLA-F/ITGB3/PSEN1/THBS2/ITGA11/RELN/WNT2B/PIK3CB/ITGA4/CASP8/MDM2/ITGAV/ATP6V1A/RHEB/JAK1/FN1/ATP6V1H/APC2/CCND3	3.66897979101249
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	22/937	103/9376	2.13729004983888	CXCL2/CXCL3/IL1B/ACTN1/RAB7B/IL1R2/IL6/NFKB1/RAB7A/LAMB3/PRKCG/LAMB1/HSPB1/IL1R1/CXCL1/LAMA3/IL10/SERPINB9/GNAL/VCL/PIK3CB/FN1	3.86713792785626
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	34/937	193/9376	1.76278609386146	CXCR4/CCL21/NFKBIA/CXCL2/CXCL3/AKT3/SRC/TIAM1/CCL20/FGR/CCL14/CCL18/PTK2B/NFKB1/STAT1/SHC3/CXCL12/CCR7/PAK1/MAP2K1/CCL3L1/ADCY3/CXCL1/GNG4/CXCL16/CCR5/GNGT2/JAK2/PIK3CB/PIK3R5/FOXO3/RASGRP2/PIK3R6/CXCL13	3.56778823863113
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	41/937	248/9376	1.65428443556994	NFKBIA/FLNA/AHNAK/RHOB/TUBB6/MYL9/HSP90AA1/IL1B/AKT3/ANXA2/BCL2/RAB7B/BIRC3/HSP90AB1/IL6/TUBB4B/NFKB1/RAB7A/IL18/S100A10/RHOH/DYNC1H1/TUBB3/GAPDH/PAK1/JUN/MAP2K1/TNFRSF10A/RHOJ/MAP2K3/TUBA4A/RIPK2/PIK3CB/TUBA1C/CASP8/MLKL/ARL8B/PLEKHM1/ACTR3C/SNX9/IRAK1	3.47948167932582
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	21/937	101/9376	2.08053932394307	SERPINE1/VEGFA/FOXO1/DIAPH1/IL1B/AKT3/BCL2/THBD/IL6/IL1A/NFKB1/STAT1/NFATC1/JUN/EGR1/JAK2/PLCD4/SMAD3/PIK3CB/FN1/PRKCE	3.63792921633431
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	15/937	62/9376	2.42090405205357	SOD2/CRYAB/FOXO1/HSPA6/AKT3/HSPA1A/HSPA1B/PRKAG2/HSPA1L/HSPA8/ADCY3/IRS2/INSR/PIK3CB/FOXO3	3.74026540989145
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	27/937	144/9376	1.87620064034152	NFKBIA/FOXO1/CXCL2/CXCL3/C1QB/IL1B/AKT3/C3/C5AR1/IL6/LPIN1/NFKB1/SCD/ALDH2/TRAF3/TICAM1/PRKAG2/C1QA/MAP2K3/CXCL1/C1QC/ADIPOR2/CASP8/CAMKK2/FOXO3/SREBF1/IRAK1	3.53058648635269
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	17/937	75/9376	2.26811810743508	SERPINE1/THBS1/CDKN1A/BCL2/ZNF385A/IGFBP3/GADD45G/TNFRSF10A/GADD45B/GADD45A/STEAP3/CD82/CASP8/PPP1R13L/MDM2/BID/CCND3	3.67396871292144
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	21/937	103/9376	2.04014050211893	SERPINE1/NFKBIA/C1QB/IL1B/AKT3/C3/IL6/NFKB1/TICAM1/JUN/C1QA/CCL3L1/IL10/C1QC/KNG1/GNAL/PIK3CB/CASP8/ACE/CFLAR/IRAK1	3.53679941771531
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	19/937	91/9376	2.08924906470264	FCGR2B/NFKBIA/CD22/AKT3/CD72/NFKB1/NFATC1/JUN/MAP2K1/LILRA6/MALT1/LILRB4/LILRB2/LILRA5/NFKBIE/BCL10/PIK3CB/LILRB1/CARD11	3.47909972873172
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	29/937	163/9376	1.78028036220545	NFKBIA/STAT4/CDKN1A/AKT3/BCL2/SRC/CREB5/PTK2B/IL6/NFKB1/STAT1/NFATC1/TRAF3/PRKCG/TICAM1/JUN/MAP2K1/IRF7/MMP9/MAP2K3/IFIH1/JAK2/SMAD3/PIK3CB/CASP8/JAK1/EGR3/BID/IRAK1	3.34852760609974
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	17/937	78/9376	2.18088279561065	ITGA5/C1QB/IL1B/C3/SERPING1/IL6/IL1A/NFKB1/IRF1/TICAM1/JUN/C1QA/C1S/IL10/IL23A/C1QC/IRAK1	3.48954871844945
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	19/937	93/9376	2.04431897728968	NFKBIA/TRAF1/CDKN1A/PTGS2/AKT3/BCL2/BIRC3/NFKB1/LAMB3/TRAF3/LAMB1/GADD45G/GADD45B/GADD45A/LAMA3/PIK3CB/CKS2/ITGAV/FN1	3.372410317424
NA	NA	hsa04517	IgSF CAM signaling	46/937	299/9376	1.53944667925458	ITGAX/CADM1/ITGA5/FOXO1/TUBB6/MYL9/CD80/MYH11/AKT3/ACTN1/SRC/KCNQ3/CRTAM/SLAMF7/EZR/TJP2/IL1RAP/JAML/TUBB4B/PRKCG/TUBB3/UNC5B/CD48/PAK1/NPHS1/MAP2K1/SORBS1/MYH9/ITGB3/LY9/NECTIN2/ROBO3/MSN/VCL/TUBA4A/CADM4/CD226/TRIO/PIK3CB/ITGA4/TUBA1C/SLAMF1/FYN/GLDN/ACTR3C/F11R	3.15880553721757
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	30/937	174/9376	1.72524196813013	DNAJB1/CRYAB/ERN1/HSP90AA1/HSPA6/PPP1R15A/BCL2/HSPA1A/HSPA1B/CAPN2/HSP90AB1/HSPH1/EIF2AK3/SEC24A/DDIT3/HSPA4L/HSPA1L/HSPA8/ERO1A/UBE2D1/DNAJA1/EDEM1/NFE2L2/HSPA5/HERPUD1/SVIP/DNAJC5B/RNF185/CUL1/P4HB	3.2175579510966
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	40/937	253/9376	1.58204006563711	NFKBIA/ITGA5/CD44/FOXO1/UBC/MYL9/DIAPH1/IL1B/AKT3/ACTN1/HK2/BCL2/C3/SRC/CAPN2/ITPR1/NFKB1/IL18/JUN/CGAS/IL1R1/MALT1/TNIP1/UBE2D1/BCL10/FNBP1/VCL/PLCD4/RIPK2/PIK3CB/RRAGD/SQSTM1/CAST/MDM2/MAP1LC3B/FOXO3/ACTR3C/PRKCE/SEPTIN6/CUL1	3.12718982515436
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	35/937	214/9376	1.6365613062169	HLA-B/HLA-A/CXCR4/NFKBIA/AKT3/BCL2/B2M/PTK2B/HLA-E/ITPR1/NFKB1/NFATC1/PRKCG/PAK1/JUN/MAP2K1/CGAS/HLA-C/AP1S3/HLA-G/MAP2K3/GNG4/TAP1/HLA-F/CCR5/GNGT2/WEE1/PIK3CB/TAPBP/CASP8/TAP2/APOBEC3A/BID/CUL1/IRAK1	3.13878753602051
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	25/937	139/9376	1.79971284445229	HSP90AA1/HSPA6/AKT3/BCL2/HSPA1A/SRC/HSPA1B/CREB5/HSP90AB1/ITPR1/FKBP4/CTSD/FKBP5/RARA/SHC3/JUN/MAP2K1/HSPA1L/HSPA8/ADCY3/MMP9/GREB1/ESR1/PIK3CB/HBEGF	3.16508909742077
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	18/937	89/9376	2.02376698284029	ITGA5/THBS1/CD44/VWF/SDC4/TNC/LAMB3/GP6/ITGB8/LAMB1/LAMA3/ITGB3/THBS2/ITGA11/RELN/ITGA4/ITGAV/FN1	3.23346630689736
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	24/937	133/9376	1.80566678168206	SOD2/CDKN1A/FOXO1/AKT3/SGK1/FBXO32/PLK3/IL6/HOMER1/PRKAG2/MAP2K1/GADD45G/GABARAPL1/GADD45B/GADD45A/IL7R/IL10/IRS2/INSR/PLK2/SMAD3/PIK3CB/MDM2/FOXO3	3.11806196654327
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	16/937	76/9376	2.10661124529574	APOA2/APOC3/OLR1/UBC/PLIN2/APOA1/SCD/ACSL4/HMGCS1/LPL/PPARD/ACSL5/SORBS1/ACSL1/FABP3/FABP4	3.22753039753723
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/937	21/9376	3.33546780505158	XYLT1/UST/CHST15/DSE/CHST11/CHST13/CSGALNACT2	3.57002762300317
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	33/937	204/9376	1.61868290539268	VEGFA/ITGA5/THBS1/CD44/CDKN1A/FLNA/MRAS/AKT3/SDC4/SRC/TIAM1/EZR/PLAU/SDC2/TIMP3/ITPR1/PRKCG/HPSE/PLAUR/PAK1/MAP2K1/MMP9/ESR1/ITGB3/IGF2/SLC9A1/WNT2B/MSN/PIK3CB/MDM2/ITGAV/HBEGF/FN1	2.97687855323566
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/937	106/9376	1.88800064436882	NFKBIA/CDKN1A/FOXO1/HSP90AA1/AKT3/BCL2/CREB5/HSP90AB1/PLAU/IL1R2/NFKB1/PDGFD/ZEB1/PDGFB/MAP2K1/MMP9/PLAT/PIK3CB/MDM2/PDGFA	3.06362980999213
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	28/937	166/9376	1.6878270820743	KCNMA1/MYL9/AKT3/CREB5/ITPR1/PPIF/NFATC1/KCNMB1/PDE2A/MAP2K1/ADRA2C/ADCY3/SLC8A2/ATP2A2/KNG1/IRS2/ADORA3/EDNRB/INSR/RGS2/PIK3R5/ATP1A1/ADRA2B/SLC8A1/GNA12/PIK3R6/PRKCE/ATP2B1	2.97929453920128
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	19/937	99/9376	1.92042085745394	LMNA/ITGA5/DES/TPM2/TTN/IL6/ITGB8/PRKAG2/SNTB1/SLC8A2/ITGB3/ITGA11/ATP2A2/ITGA4/ITGAV/EMD/SLC8A1/ACE/CACNB2	3.06768110076787
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	32/937	205/9376	1.56197516724367	HLA-B/HLA-A/NFKBIA/TRAF1/CDKN1A/ACTN1/C3/SRC/CREB5/HLA-E/PKM/NFKB1/TRAF3/JUN/IRF7/HLA-C/HLA-G/EIF2AK2/HLA-F/CCR5/NFKB2/MAPKAPK2/GTF2A1/PIK3CB/YWHAH/CASP8/YWHAG/GSN/MDM2/JAK1/EGR3/CCND3	2.71078859163734
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	12/937	55/9376	2.18321529057922	PSAP/SPHK1/SGMS2/SGPP2/B4GALT5/HEXB/GM2A/SGPL1/SAMD8/CERK/NEU4/UGCG	2.93240400736547
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	27/937	168/9376	1.60817197743558	STAT4/FTH1/GLUL/TNFAIP3/HSP90AA1/IL1B/BCL2/CAPN2/BIRC3/HSP90AB1/PLA2G4C/IL1A/STAT1/TICAM1/TNFRSF10A/EIF2AK2/CHMP1B/JAK2/GLUD1/CASP8/SQSTM1/MLKL/JAK1/CFLAR/BID/FTL/CHMP4B	2.65038113205092
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	19/937	110/9376	1.72837877170855	THBS1/TF/INHBA/EMP3/SKIL/HAMP/SMAD7/TFRC/ID2/FBN1/SKI/SMAD3/BMP8A/LRRC32/BMP2/BMP6/CUL1/ACVR1B/LEFTY2	2.56045657599259
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	11/937	52/9376	2.11673918397504	APOA2/APOC3/APOA1/APOB/LDLR/APOC2/APOC1/LPL/SOAT1/APOE/APOH	2.69068113905546
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	22/937	134/9376	1.64284235174182	KCNMA1/ACTG2/ADM/MYL9/MYH11/PRKCH/ACTA2/PLA2G4C/ITPR1/PRKCG/KCNMB1/RAMP1/CALCRL/MAP2K1/ADCY3/RAMP3/MYH9/ADORA2A/PLA2G5/GNA12/PRKCE/ADORA2B	2.49737545211623
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	20/937	120/9376	1.66773390252579	NFKBIA/AKT3/BCL2/RAPGEF1/NFKB1/ZNF274/SHC3/JUN/MAP2K1/IRAK3/IRAK2/NFKBIE/PSEN1/MAPKAPK2/PRDM4/RIPK2/PIK3CB/RPS6KA3/FOXO3/IRAK1	2.45297045457158
Human Diseases	Cancer: specific types	hsa05214	Glioma	14/937	76/9376	1.84328483963377	CDKN1A/AKT3/CAMK1D/PRKCG/SHC3/CAMK1/PDGFB/MAP2K1/GADD45G/GADD45B/GADD45A/PIK3CB/MDM2/PDGFA	2.45951544887195
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	9/937	41/9376	2.19652757893641	VEGFA/THBS1/CDKN1A/SRC/TYMP/MAP2K1/MMP9/MDM2/HBEGF	2.55839395707171
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	22/937	138/9376	1.59522373285076	NFKBIA/ITGA5/IL1B/AKT3/SRC/PTK2B/IL6/NFKB1/IL18/NFATC1/TICAM1/JUN/MAP2K1/MAP2K3/IL10/PIK3CB/RPS6KA3/ITGA4/ACTR3C/WIPF3/FN1/IRAK1	2.34714945152508
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	14/937	77/9376	1.81934607548268	NFKBIA/CDKN1A/AKT3/NFKB1/SHC3/MAP2K1/GADD45G/GADD45B/GADD45A/SMAD3/PIK3CB/CTBP2/MDM2/BCR	2.40549554428448
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	22/937	140/9376	1.57243482238146	SERPINE1/SPHK1/MRAS/AKT3/ACTA2/ITPR1/PRKAG2/MAP2K1/ADCY3/SLC8A2/GNG4/SLC9A1/PLAT/EGR1/GNGT2/ADCY10/SMAD3/PIK3R5/MAP1LC3B/SLC8A1/PIK3R6/PRKCE	2.27383025518092
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	18/937	109/9376	1.65243359149344	NFKBIA/IL1B/CD80/AKT3/IL6/NFKB1/STAT1/TRAF3/TICAM1/JUN/MAP2K1/IRF7/CCL3L1/MAP2K3/PIK3CB/CASP8/JAK1/IRAK1	2.28291594212529
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	13/937	71/9376	1.8321583717889	AKT3/SRC/NFKB1/STAT1/IRF1/SHC3/MAP2K1/ESR1/JAK2/PIK3CB/PRLR/FOXO3/SOCS1	2.34523794626817
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	13/937	71/9376	1.8321583717889	NFKBIA/CXCL2/CXCL3/SRC/NFKB1/ADAM17/PAK1/JUN/CXCL1/ATP6V1A/HBEGF/ATP6V1H/F11R	2.34523794626817
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	15/937	86/9376	1.74530292124792	LMNA/ITGA5/DES/ITGB8/JUP/SNTB1/SLC8A2/ITGB3/ITGA11/ATP2A2/ITGA4/ITGAV/EMD/SLC8A1/CACNB2	2.31357792756927
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	35/937	250/9376	1.40089647812167	HLA-B/HLA-A/CXCR4/HSPA6/HSPA1A/SRC/HSPA1B/LDLR/IGF2R/HLA-E/RAB7A/TFRC/HSPA1L/ARFGAP3/HLA-C/HSPA8/HLA-G/RAB31/HLA-F/CCR5/IL2RA/AGAP3/CHMP1B/SPART/IL2RG/PSD/SMAD3/MDM2/RAB11FIP3/NEDD4/EHD1/ACTR3C/WIPF3/CHMP4B/SNX32	2.14077957877757
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	29/937	200/9376	1.45092849519744	NFKBIA/TUBB6/IL1B/MYH11/SRC/EZR/IL6/TUBB4B/NFKB1/IL18/SEC24A/TUBB3/GAPDH/MYO1G/PAK1/JUN/IL1R1/TNFRSF10A/CLDN1/MYH9/TUBA4A/LPAR1/TUBA1C/CASP8/FYN/ACTR3C/WIPF3/GNA12/IRAK1	2.14785973137088
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	32/937	226/9376	1.41683588179182	NFKBIA/MYL9/AKT3/TIAM1/CREB5/HCAR3/NFKB1/NFATC1/PDE4A/OXTR/HCAR2/PAK1/JUN/MAP2K1/ADCY3/CRH/SLC9A1/SUCNR1/PTGER2/ADORA2A/ATP2A2/ADCY10/PDE4C/PIK3CB/SSTR2/PTGER3/GIPR/ATP1A1/FFAR2/POPDC2/RAPGEF4/ATP2B1	2.11358009035913
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	29/937	201/9376	1.44370994547009	CDK14/TRAF1/CDKN1A/FOXO1/BIRC3/PLAU/ZBTB16/IL1R2/IL6/DOT1L/NFKB1/RUNX2/RARA/ZEB1/DDIT3/JUP/CEBPB/IGFBP3/ID2/GADD45G/GADD45B/MMP9/FLT1/GADD45A/PLAT/NUPR1/MDM2/PDGFA/AFF1	2.11886894442338
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	25/937	169/9376	1.48023719159094	CTSB/UBC/MRAS/ERN1/AKT3/BCL2/RAB7B/ITPR1/DDIT4/CTSD/EIF2AK3/RAB7A/MAP2K1/GABARAPL1/IRS2/VMP1/PIK3CB/RRAGD/CAMKK2/SQSTM1/TANK/MAP1LC3B/PLEKHM1/RHEB/CFLAR	2.0991816027456
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	15/937	89/9376	1.68647248570024	TUBB6/SRC/ITPR1/TUBB4B/PDGFD/PRKCG/PDGFB/TUBB3/MAP2K1/ADCY3/TUBA4A/LPAR1/TUBA1C/HTR2B/PDGFA	2.16815514695114
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	35/937	254/9376	1.37883511626148	CXCR4/VEGFA/SPHK1/CAMK1D/PTK2B/ITPR1/PDGFD/PPIF/NFATC1/CD38/PRKCG/CAMK1/OXTR/PDGFB/ADCY3/FLT1/SLC8A2/ORAI2/FLT4/ITPKC/ADORA2A/ATP2A2/GNAL/PLCD4/EDNRB/P2RX1/CYSLTR2/PTGER3/HTR7/SLC8A1/HTR2B/PDGFA/P2RX7/ATP2B1/ADORA2B	2.03953890394434
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	17/937	105/9376	1.62008436245363	LMNA/ITGA5/DES/TPM2/TTN/ITGB8/SNTB1/ADCY3/SLC8A2/ITGB3/ITGA11/ATP2A2/ITGA4/ITGAV/EMD/SLC8A1/CACNB2	2.12908048112239
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	30/937	212/9376	1.41600048327662	VEGFA/SIPA1L1/THBS1/DOCK4/MRAS/AKT3/SRC/TIAM1/RAPGEF1/PDGFD/RALGDS/PRKCG/RASSF5/PDGFB/MAP2K1/CNR1/ADCY3/MAP2K3/FLT1/FLT4/ITGB3/ADORA2A/INSR/LPAR1/PIK3CB/EFNA2/PDGFA/RASGRP2/RAPGEF4/ADORA2B	2.0414049596336
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	33/937	238/9376	1.38744249033658	NFKBIA/C1QB/IL1B/MX2/VWF/C3/CSF3/C5AR1/OAS2/MX1/IL6/NFKB1/STAT1/ISG15/TRAF3/PRKCG/ADAM17/JUN/CGAS/C1QA/OAS3/EIF2AK2/C1S/IL6R/IFIH1/C1QC/PIK3CB/C7/ADAR/ACE/HBEGF/JAK1/IRAK1	2.0173445966172
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	15/937	90/9376	1.66773390252579	SOD2/FOXO1/AKT3/CREB5/NFKB1/PRKAG2/ADCY3/IRS2/INSR/PIK3CB/ADIPOR2/CAMKK2/EIF4E/RHEB/FOXO3	2.12090044033186
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/937	90/9376	1.66773390252579	NFKBIA/AKT3/NFKB1/STAT1/NFATC1/TICAM1/JUN/MAP2K1/MAP2K3/NFKBIE/CD274/JAK2/PIK3CB/BATF3/JAK1	2.12090044033186
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	21/937	138/9376	1.52271356317572	FOXO1/AKT3/HK2/RAPGEF1/SHC3/PRKAG2/INPP5A/MAP2K1/GYS1/SORBS1/PTPN1/RHOQ/IRS2/INSR/PIK3CB/PPP1R3B/EIF4E/FBP1/RHEB/SREBF1/SOCS1	2.06121964800795
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	13/937	75/9376	1.73444325862682	CDKN1A/AKT3/BCL2/BIRC3/GSTO2/MGST1/SLC31A1/PIK3CB/CASP8/POLH/MDM2/GSTM3/BID	2.12781564886625
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	11/937	60/9376	1.83450729277837	VEGFA/SPHK1/PTGS2/AKT3/SRC/PLA2G4C/PRKCG/HSPB1/MAP2K1/MAPKAPK2/PIK3CB	2.16073228861817
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	18/937	115/9376	1.56621966498074	CDKN1A/SGK1/BCL2/CREB5/JUND/VDR/ITPR1/PDE4A/RUNX2/PRKCG/MAFB/AKAP13/MAP2K1/ADCY3/EGR1/PDE4C/HBEGF/GNA12	2.03570510975044
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	23/937	156/9376	1.47530306761897	NFKBIA/CDKN1A/MX2/AKT3/LDLR/OAS2/MX1/NFKB1/STAT1/TRAF3/TICAM1/MAP2K1/IRF7/CLDN1/OAS3/EIF2AK2/PIK3CB/YWHAH/CASP8/YWHAG/JAK1/CFLAR/BID	1.99469912013911
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	22/937	149/9376	1.47745553780808	SPHK1/MRAS/AKT3/PTK2B/PLA2G4C/PDGFD/RALGDS/SHC3/PDGFB/DGKA/MAP2K1/ADCY3/INSR/LPAR1/PIK3CB/PIK3R5/FYN/RHEB/PDGFA/GNA12/PIK3R6/RAPGEF4	1.95751793141898
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	13/937	77/9376	1.68939278437678	VEGFA/CDKN1A/AKT3/NFKB1/STAT1/RALGDS/MAP2K1/GADD45G/GADD45B/GADD45A/SMAD3/PIK3CB/JAK1	2.02396926122246
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	17/937	109/9376	1.56063172529936	NFKBIA/FOXO1/AKT3/CREB5/IL6/NFKB1/PRKAG2/GFPT2/GYS1/PTPN1/IRS2/INSR/PIK3CB/RPS6KA3/PPP1R3B/SREBF1/PRKCE	1.9616940636325
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	12/937	70/9376	1.71538344259796	NFKBIA/AKT3/NFKB1/PRKAG2/ACSL4/NFKBIE/ACSL5/ACSL1/JAK2/IRS2/ADIPOR2/CAMKK2	2.00177988260415
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	21/937	143/9376	1.46947183019755	HLA-DQB1/HLA-DRB5/HLA-DQA1/HLA-DRB1/HLA-DRA/HLA-DPB1/HLA-DPA1/HLA-DQA2/HLA-DOA/HLA-DMA/C1QB/CD80/ACTN1/HLA-DQB2/C3/HLA-DMB/C1QA/C1S/IL10/C1QC/C7	1.8850205081389
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	7/937	34/9376	2.06014187959068	BHLHE40/NFIL3/RORB/PRKAG2/RORA/NR1D1/CUL1	2.06344766486344
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/937	50/9376	1.80115261472785	THBS1/IL1B/CSF3/SDC2/ACKR1/IL6/IL18/IL10/THBS2	1.89261593023668
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	18/937	122/9376	1.47635460223595	AKT3/CREB5/ITPR1/STAT1/PRKCG/SHC3/MAP2K1/IGFBP3/ADCY3/JUNB/MAP2K3/CSH2/JAK2/ADCY10/IRS2/PIK3CB/SSTR2/SOCS1	1.76463737527618
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	15/937	99/9376	1.5161217295689	IL1B/SRC/PRKCH/PLA2G4C/ITPR1/IL1RAP/PRKCG/IL1R1/ADCY3/MAP2K3/PTGER2/KNG1/PIK3CB/HTR2B/PRKCE	1.72018795822798
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	15/937	99/9376	1.5161217295689	AKT3/PLA2G4C/GPCPD1/PDGFD/RALGDS/SLC22A4/PRKCG/PDGFB/JUN/DGKA/MAP2K1/SLC22A1/PIK3CB/RHEB/PDGFA	1.72018795822798
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	11/937	67/9376	1.64284235174182	HK2/PKM/ALDH2/ALDOB/GAPDH/ALDOC/LDHA/ENO2/FBP1/ENO1/TPI1	1.75954471363654
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	12/937	75/9376	1.60102454642476	GLUL/SDS/PKM/SDSL/ALDOB/GAPDH/MAT2A/ALDOC/ENO2/ENO1/TKTL1/TPI1	1.74127738285246
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	17/937	116/9376	1.46645567291061	CXCR4/MYL9/ACTN1/PTK2B/EZR/PRKCG/RHOH/CXCL12/RASSF5/CLDN1/MMP9/MSN/VCL/PIK3CB/ITGA4/RAPGEF4/F11R	1.68439452338688
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	7/937	37/9376	1.89310334881306	IL1B/APOA1/IL6/IL18/PRKCG/IL10/KNG1	1.81368696759111
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	18/937	125/9376	1.44092209178228	SPHK1/SGMS2/AKT3/BCL2/SGPP2/CTSD/NFKB1/PRKCG/MAP2K1/KNG1/ADORA3/NSMAF/PIK3CB/SGPL1/FYN/GNA12/BID/PRKCE	1.65360762157973
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	5/937	23/9376	2.17530509025103	CTSA/ANPEP/REN/ACE/MME	1.88039465536366
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	5/937	23/9376	2.17530509025103	CA2/GLS/GLUD1/AQP1/ATP1A1	1.88039465536366
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	31/937	238/9376	1.30335506667982	VEGFA/MRAS/AKT3/TIAM1/PLA2G4C/NFKB1/PDGFD/RALGDS/PRKCG/SHC3/ETS2/RASSF5/ABL2/PDGFB/PAK1/MAP2K1/FLT1/GNG4/PLA1A/FLT4/IGF2/GNGT2/PLA2G5/RASGRF1/INSR/PIK3CB/HTR7/EFNA2/PDGFA/RASA3/RASGRP2	1.57951623760044
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	4/937	17/9376	2.35444786238935	GLUL/CA2/GLUD1/CA13	1.86243862287221
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/937	17/9376	2.35444786238935	MYH11/TFRC/MYH9/PCDH7	1.86243862287221
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	13/937	86/9376	1.51259586508153	CDKN1A/EREG/AKT3/SRC/PRKCG/SHC3/ABL2/PAK1/JUN/MAP2K1/PIK3CB/NRG2/HBEGF	1.5912059988041
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	9/937	54/9376	1.66773390252579	SDS/IL4I1/SDSL/MAT2A/LDHA/GCLC/LACC1/GCLM/AHCYL1	1.63966715743572
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	10/937	62/9376	1.61393603470238	HES1/ADAM17/NRARP/NCOR2/LFNG/PSEN1/TLE3/SPEN/CTBP2/TLE2	1.6160723246334
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	21/937	154/9376	1.36450955661201	CDKN1A/MYL9/PTGS2/SRC/CAMK1D/PLA2G4C/ITPR1/NFATC1/CD38/PRKCG/PRKAG2/CAMK1/OXTR/JUN/MAP2K1/ADCY3/CAMKK2/RGS2/PIK3R5/CACNB2/PIK3R6	1.5197307839063
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	13/937	87/9376	1.49520970571278	CDKN1A/EREG/AKT3/BCL2/RALGDS/JUN/MAP2K1/GADD45G/GADD45B/GADD45A/SMAD3/PIK3CB/APC2	1.5462304905398
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	17/937	122/9376	1.39433490211173	FOXO1/AKT3/CREB5/PFKFB3/SCD/PRKAG2/GYS1/IRS2/TBC1D1/INSR/PIK3CB/ADIPOR2/CAMKK2/FBP1/RHEB/FOXO3/SREBF1	1.46079853826532
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	17/937	122/9376	1.39433490211173	THRB/FOXO1/AKT3/SRC/STAT1/PRKCG/MAP2K1/ESR1/ITGB3/SLC9A1/ATP2A2/PLCD4/PIK3CB/ATP1A1/MDM2/ITGAV/RHEB	1.46079853826532
NA	NA	hsa04081	Hormone signaling	28/937	219/9376	1.27935751426636	THRB/SRC/HAMP/OXTR/RAMP1/ADRA2C/ADCY3/GNG4/RAMP3/CRH/ESR1/ITGB3/IGF2/CSH2/GNGT2/JAK2/IRS2/INSR/PIK3CB/ADIPOR2/SSTR2/GIPR/PRLR/ADRA2B/ITGAV/GNA12/RAPGEF4/MC1R	1.39384906535937
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	11/937	73/9376	1.5078142132425	CXCR4/MX2/MX1/ELL2/SUPT5H/ELL/CCR5/MAP1B/MDFIC/APOBEC3A/CHMP4B	1.45132511916603
Human Diseases	Cancer: specific types	hsa05218	Melanoma	11/937	73/9376	1.5078142132425	CDKN1A/AKT3/PDGFD/PDGFB/MAP2K1/GADD45G/GADD45B/GADD45A/PIK3CB/MDM2/PDGFA	1.45132511916603
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/937	12/9376	2.50160085378869	FCGR2B/SLAMF1/ASGR1	1.73430057171156
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	9/937	57/9376	1.5799584339718	ELOVL5/ELOVL7/SCD/ACSL4/ACSL5/ACSL1/ACAT2/PPT1/FADS1	1.46338830739373
Organismal Systems	Digestive system	hsa04976	Bile secretion	13/937	90/9376	1.44536938218902	ABCC3/LDLR/CA2/AQP9/ABCB4/BAAT/ADCY3/ABCB1/SLC22A1/SLC9A1/UGT2B7/AQP1/ATP1A1	1.41461159186617
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	4/937	19/9376	2.10661124529574	IDS/HEXB/HPSE/GNS	1.6088424067294
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/937	42/9376	1.66773390252579	KMO/IL4I1/ALDH2/KYNU/ACAT2/MAOB/AFMID	1.44512067404352
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	31/937	250/9376	1.24079402347919	PSAP/CTSB/CTSA/IGF2R/CTSH/IDS/LITAF/CTSD/RAB7A/CTSS/HEXB/SLC11A1/ACP5/GM2A/AP1S3/CTSZ/LAPTM5/ARSG/CLN8/LAMP3/RRAGD/SLC36A3/PPT1/SLC2A6/ARL8B/ATP6V1A/PLEKHM1/SLC36A4/AP4B1/GNS/ATP6V1H	1.28583551187869
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	5/937	27/9376	1.8530376694731	ELOVL5/ELOVL7/SCD/BAAT/FADS1	1.47903159708134
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	9/937	59/9376	1.52640052095581	PTGS2/AKT3/MGLL/ADCY3/FABP4/IRS2/INSR/PIK3CB/PTGER3	1.35149426983999
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	9/937	59/9376	1.52640052095581	CDKN1A/AKT3/MAP2K1/GADD45G/GADD45B/GADD45A/PIK3CB/FOXO3/APC2	1.35149426983999
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	6/937	35/9376	1.71538344259796	HK2/PFKFB3/ALDOB/ALDOC/FBP1/TPI1	1.41281780876337
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	17/937	128/9376	1.32897545357524	AMPD3/PNP/ADA/PAPSS2/ADA2/PDE4A/PDE2A/ADCY3/LACC1/ADCY10/AK4/PDE4C/PDE8A/NT5E/ENPP4/AMPD2/ADK	1.24868964099051
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	12/937	85/9376	1.41266871743361	UPP1/AMPD3/PNP/ADA/TYMP/ADA2/LACC1/AK4/NT5E/AMPD2/ADK/UCK2	1.27347294042072
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	6/937	36/9376	1.66773390252579	GALNT15/B4GALT5/GALNT18/ST6GALNAC2/GALNT6/GALNT2	1.33749195826276
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	10/937	70/9376	1.42948620216496	VEGFA/CDKN1A/AKT3/RAPGEF1/PDGFB/PAK1/JUN/MAP2K1/EGLN3/PIK3CB	1.20178464884188
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	7/937	45/9376	1.55655164235741	ABCC3/ABCB4/ABCB1/ABCA6/DEFB1/TAP1/TAP2	1.24697449592303
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	5/937	29/9376	1.72524196813013	TEAD1/LATS2/RASSF2/PAK1/SAV1	1.3033340623765
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	10/937	71/9376	1.40935259368377	SLC7A5/AKT3/HK2/SLC16A3/PKM/MAP2K1/GLS/SCO2/LDHA/PIK3CB	1.15366169308215
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	15/937	115/9376	1.30518305415062	AKT3/BCL2/KCNQ3/CREB5/ITPR1/PRKCG/MAP2K1/ADCY3/GNG4/GNGT2/JAK2/PIK3CB/PIK3R5/FYN/PIK3R6	1.09721145549544
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	17/937	133/9376	1.27901397035813	HLA-B/HLA-A/PTK2B/HLA-E/NFATC1/PRKCG/SHC3/CD48/PAK1/MAP2K1/TNFRSF10A/HLA-C/HLA-G/PIK3CB/FYN/BID/KLRD1	1.07982961304618
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	6/937	38/9376	1.5799584339718	CIITA/ADA/IL7R/TAP1/IL2RG/TAP2	1.19363535019813
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/937	98/9376	1.32738004486747	NR4A1/CAMK1D/LDLR/CREB5/ITPR1/PRKCG/CAMK1/PDE2A/ADCY3/ATP1A1/PRKCE/DAGLA/ATP2B1	1.08554541619343
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	10/937	72/9376	1.38977825210483	NFKBIA/NFKB1/ISG15/TRAF3/ZNFX1/IRF7/IFIH1/CASP8/TANK/ADAR	1.10626441134303
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	15/937	116/9376	1.2939314760976	SDS/HK2/PKM/SDSL/ALDOB/GAPDH/ACAT2/ALDOC/GLUD1/ENO2/FBP1/ENO1/TKTL1/TPI1/OGDH	1.06140110913539
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	7/937	47/9376	1.49031540225709	HK2/PKM/IRS2/INSR/PIK3CB/SOCS1/PRKCE	1.1228373707236
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	13/937	99/9376	1.31397216562638	CDKN1A/AKT3/BCL2/SRC/SHC3/JUN/MAP2K1/ADCY3/MMP9/ESR1/PIK3CB/MDM2/HBEGF	1.04644138695804
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	10/937	73/9376	1.37074019385681	CDKN1A/AKT3/PRKCG/RASSF5/MAP2K1/GADD45G/GADD45B/GADD45A/PIK3CB/FOXO3	1.05956970482025
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/937	83/9376	1.32614985020123	NFKBIA/IL1B/IL6/NFKB1/IL18/IRF7/CGAS/AIM2/CASP8/MLKL/ADAR	0.994462019510278
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	3/937	16/9376	1.87620064034152	IL4I1/MAOB/AOC3	1.1687875407791
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	10/937	75/9376	1.33418712202063	ALB/GPX3/CREB5/ITPR1/PRKCG/TTR/ADCY3/HSPA5/ATP1A1/ASGR1	0.96820085082487
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/937	24/9376	1.66773390252579	XYLT1/HS3ST2/NDST1/HS3ST3B1	1.09135675027664
Organismal Systems	Digestive system	hsa04970	Salivary secretion	12/937	93/9376	1.2911488277619	KCNMA1/ITPR1/LYZ/CD38/PRKCG/CST3/ADCY3/SLC12A2/SLC9A1/ATP1A1/KCNN4/ATP2B1	0.940204412638751
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	19/937	157/9376	1.21096601839452	ERN1/IL1B/AKT3/IL6/IL1A/NFKB1/EIF2AK3/PRKAG2/DDIT3/JUN/IL6R/IRS2/INSR/PIK3CB/ADIPOR2/CASP8/COX7A1/SREBF1/BID	0.888240078814907
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	16/937	130/9376	1.23155734340366	VEGFA/NFKBIA/AKT3/SRC/CREB5/ACTA2/NFKB1/SHC3/JUN/MAP2K1/ADCY3/MMP9/GNG4/GNGT2/EDNRB/PIK3CB	0.885856202218202
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	19/937	158/9376	1.20330167650595	SLC7A5/AKT3/SGK1/LPIN1/FNIP2/DDIT4/PRKCG/MAP2K1/WNT2B/INSR/TBC1D7/PIK3CB/RPS6KA3/RRAGD/EIF4E/ATP6V1A/RHEB/GRB10/ATP6V1H	0.858738811727978
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/937	33/9376	1.5161217295689	STX11/STX3/VAMP5/STX4/SNAP23	0.989636898809035
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	3/937	17/9376	1.76583589679201	BAAT/CYP7B1/HSD3B7	1.05306552771347
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	20/937	170/9376	1.17722393119468	MYL9/MYH11/ACTN1/SRC/TIAM1/EZR/TJP2/PRKAG2/JUN/CLDN1/YBX3/MYH9/MSN/TUBA4A/TUBA1C/NEDD4/ACTR3C/HSPA4/PRKCE/F11R	0.777000469983675
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	20/937	170/9376	1.17722393119468	CDKN1A/AKT3/PRKCG/HMOX1/SHC3/GSTO2/MAP2K1/GADD45G/MGST1/TXNRD1/GADD45B/GADD45A/IGF2/NFE2L2/WNT2B/SMAD3/PIK3CB/NQO1/GSTM3/APC2	0.777000469983675
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	4/937	26/9376	1.53944667925458	APOA1/APOB/TCN2/CUBN	0.917781570805286
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/937	52/9376	1.34701584434775	PTGS2/LDLR/PLA2G4C/ADCY3/INSR/BMP6/HSD17B7	0.836103004836243
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	2/937	10/9376	2.00128068303095	PAPSS2/SQOR	1.05557404057513
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/937	18/9376	1.66773390252579	ACSL4/ACSL5/ACSL1	0.944839626662744
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	36/937	323/9376	1.11526477692127	VIM/VEGFA/ITGA5/THBS1/CD44/CDKN1A/PTGS2/SLC7A1/BCL2/MCL1/TNC/EZR/PLAU/TIMP3/EZH2/DDIT4/NFKB1/PRKCG/HMOX1/ZEB1/PDGFB/MAP2K1/ST14/GLS/MMP9/ABCB1/SOX4/ITGB3/IRS2/PIK3CB/MDM2/EFNA2/SOCS1/PDGFA/PRKCE/APC2	0.702443754144335
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	12/937	98/9376	1.22527388756997	FCGR2B/SPHK1/AKT3/PLA2G4C/PRKCG/MARCKSL1/PAK1/MAP2K1/PIK3CB/GSN/ACTR3C/PRKCE	0.746975998914822
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	11/937	89/9376	1.23674648951351	GLUL/SRC/PRKCG/GABARAPL1/GABRB2/GLS/ADCY3/SLC38A2/GNG4/GNGT2/SLC38A1	0.747740267022836
Organismal Systems	Immune system	hsa04611	Platelet activation	15/937	126/9376	1.19123850180414	AKT3/VWF/SRC/PLA2G4C/ITPR1/GP6/ADCY3/ITGB3/PIK3CB/P2RX1/PIK3R5/FYN/RASGRP2/SNAP23/PIK3R6	0.720111388140984
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	7/937	53/9376	1.32160045105817	VDR/PRKCG/SLC8A2/ESR1/ATP1A1/SLC8A1/ATP2B1	0.782324051200731
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	8/937	63/9376	1.27065440192441	CDKN1A/GADD45G/GADD45B/GADD45A/WNT2B/PTCH2/BMP2/APC2	0.718208446428014
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	21/937	184/9376	1.14203517238179	CXCR4/SEMA4A/PLXNC1/MYL9/EPHB2/SRC/SEMA6B/CXCL12/UNC5B/SEMA3C/PAK1/DPYSL2/SSH1/ROBO3/BOC/EPHB6/PIK3CB/TRPC4/FYN/EFNA2/SEMA4B	0.64835034541816
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/937	37/9376	1.35221667772361	GLUL/IL4I1/GFPT2/GLS/GLUD1	0.715270857515583
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	5/937	37/9376	1.35221667772361	CDKN1A/MAP2K1/GADD45G/GADD45B/GADD45A	0.715270857515583
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	10/937	83/9376	1.20559077291021	L3MBTL4/JARID2/EZH2/PCGF5/PHF19/RYBP/PHC2/SFMBT2/UBE2D1/TEX10	0.626865887244227
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	12/937	102/9376	1.17722393119468	KCNMA1/ITPR1/CA2/CD38/PRKCG/ADCY3/SLC12A2/SLC9A1/ATP2A2/PLA2G5/ATP1A1/ATP2B1	0.599651392022664
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/937	65/9376	1.23155734340366	MGLL/LPIN1/GPAT3/ALDH2/DGKA/LPL/GPAT4/MOGAT1	0.624204670073841
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	8/937	65/9376	1.23155734340366	AKT3/ITPR1/PRKCG/MAP2K1/PIK3CB/TRPC4/KCNN4/KCNN1	0.624204670073841
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	20/937	178/9376	1.12431499046683	FOSL1/NFATC1/PRKCG/DKK1/JUN/CCN4/PPARD/PSEN1/TLE3/CACYBP/WNT2B/SMAD3/CTBP2/CELSR1/PRICKLE2/TBL1X/TLE2/APC2/CUL1/CCND3	0.557951872906615
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	11/937	93/9376	1.18355309211508	MYL9/ACTN1/SRC/SNAI1/SORBS1/PTPN1/NECTIN2/VCL/INSR/SMAD3/FYN	0.592746426240859
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/937	38/9376	1.31663202830984	UAP1/HK2/HEXB/GFPT2/UGDH	0.651672878359985
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/937	38/9376	1.31663202830984	SGK1/PRKCG/INSR/PIK3CB/ATP1A1	0.651672878359985
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	12/937	103/9376	1.16579457263939	COL18A1/COL23A1/SLC8A2/SLC38A2/COL12A1/COL11A1/SLC36A3/ATP1A1/SLC8A1/KCNN4/SLC36A4/MME	0.563752826446807
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	14/937	122/9376	1.14827580173907	NFKBIA/AKT3/NFKB1/NFATC1/PAK1/JUN/MAP2K1/MALT1/NFKBIE/IL10/BCL10/PIK3CB/FYN/CARD11	0.549282027232734
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	12/937	104/9376	1.15458500944093	SGMS2/PLA2G4C/LPIN1/GPCPD1/GPAT3/DGKA/PLA1A/MBOAT7/PLA2G5/SAMD8/GPAT4/PLD3	0.528210798154063
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/937	48/9376	1.25080042689434	AKT3/HK2/SLC2A5/MGAM/PIK3CB/ATP1A1	0.580449660565809
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	3/937	21/9376	1.42948620216496	DPYD/ALDH2/UPB1	0.65651840805135
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/937	30/9376	1.33418712202063	IL1B/ABCC3/IL6/NFKB1	0.610868019717015
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	12/937	105/9376	1.14358896173197	UBC/MRAS/RAB7B/SRC/EIF2AK3/RAB7A/JUN/GABARAPL1/BCL2L13/SQSTM1/MAP1LC3B/FOXO3	0.493017521871523
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	13/937	115/9376	1.13115864693054	PTGS2/DUSP1/PLA2G4C/ITPR1/PRKCG/MAP2K1/GABRB2/GNG4/MAOB/GNGT2/HTR7/ALOX15B/HTR2B	0.471549019325438
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/937	49/9376	1.22527388756997	GALNT15/LFNG/B4GALT1/GALNT18/GALNT6/GALNT2	0.526802522215486
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	16/937	144/9376	1.11182260168386	AKT3/INHBA/SKIL/JARID2/PCGF5/MAP2K1/ID2/LIF/JAK2/WNT2B/SMAD3/PIK3CB/JAK1/APC2/ACVR1B/LEFTY2	0.450581006446147
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	8/937	68/9376	1.17722393119468	AKT3/ZBTB16/NFKB1/RARA/JUP/MAP2K1/PPARD/PIK3CB	0.488718270391689
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	17/937	154/9376	1.1046029744002	AKT3/BCL2/TPM2/CREB5/KCNE1/ADCY3/SLC8A2/SLC9A1/ATP2A2/PIK3R5/ATP1A1/POPDC2/SLC8A1/CACNB2/PIK3R6/RAPGEF4/ATP2B1	0.436115754444687
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	4/937	31/9376	1.2911488277619	ALDOB/ALDOC/FBP1/TKTL1	0.541023562930427
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	4/937	31/9376	1.2911488277619	DPYD/ALDH2/AOC3/UPB1	0.541023562930427
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	7/937	59/9376	1.18720040518785	GPX3/GSTO2/MGST1/ANPEP/GCLC/GCLM/GSTM3	0.480623146921895
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	9/937	78/9376	1.15458500944093	SYNJ2/INPP5A/INPP1/ITPK1/ITPKC/PLCD4/PIK3CB/TPI1/MTMR8	0.456803946666998
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/937	78/9376	1.15458500944093	BTG1/BTG3/PABPC4/HSPD1/PABPC1/PNLDC1/ENO2/ENO1/TOB1	0.456803946666998
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	9/937	78/9376	1.15458500944093	ITGA5/ARHGAP10/SRC/SHC3/VCL/PIK3CB/ACTR3C/FN1/SEPTIN6	0.456803946666998
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	11/937	98/9376	1.12316773027247	ITPR1/SYNJ2/PRKCG/INPP5A/DGKA/INPP1/ITPK1/ITPKC/PLCD4/PIK3CB/MTMR8	0.40840658163621
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/937	41/9376	1.22029309940912	SDS/SDSL/MAOB/AOC3/DMGDH	0.47102678135832
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/937	32/9376	1.25080042689434	BCL2/BIRC3/CASP8/BID	0.473529222995498
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	17/937	157/9376	1.0834959111951	SERPINE1/BIRC3/SMAD7/TEAD1/LATS2/ID2/TP53BP2/WNT2B/SMAD3/YWHAH/YWHAG/BMP8A/SAV1/BMP2/BMP6/APC2/CCND3	0.351546733948236
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	6/937	51/9376	1.17722393119468	TJP2/ERO1A/ADCY3/SLC12A2/ATP6V1A/ATP6V1H	0.422856464063673
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/937	23/9376	1.30518305415062	GLUL/GLS/GLUD1	0.488268611012152
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	29/937	275/9376	1.05522072377996	MT-ATP8/C1QB/TUBB6/HSPA6/IL1B/HSPA1A/HSPA1B/CREB5/IL6/ITPR1/IL1A/TUBB4B/EIF2AK3/PPIF/STIP1/DDIT3/TUBB3/HSPA1L/HSPA8/C1QA/EGR1/C1QC/HSPA5/TUBA4A/PIK3CB/TUBA1C/C7/FYN/COX7A1	0.309694736739004
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	23/937	217/9376	1.06058653709013	VEGFA/HSP90AA1/AHR/AKT3/BCL2/SRC/CREB5/HSP90AB1/VDR/NFKB1/PRKCG/GSTO2/JUN/MAP2K1/MGST1/ADCY3/ESR1/UGT2B7/JAK2/PIK3CB/RPS6KA3/GSTM3/CCND3	0.300879021549284
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/937	14/9376	1.42948620216496	B3GNT7/B4GALT1	0.535844596646013
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	5/937	43/9376	1.16353528083195	ALDH2/ACSL4/ACSL5/ACSL1/ACAT2	0.358133540494365
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	9/937	82/9376	1.0982637894682	UPP1/TYMP/DPYD/GSTO2/MGST1/UGT2B7/UPB1/GSTM3/UCK2	0.297789266957834
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	10/937	93/9376	1.07595735646825	SRC/PTK2B/PLA2G4C/ITPR1/JUN/MAP2K1/ADCY3/MAP2K3/EGR1/HBEGF	0.245288439842966
Cellular Processes	Cell motility	hsa04814	Motor proteins	20/937	194/9376	1.03158798094379	ACTG2/TUBB6/MYL9/MYH11/TPM2/ACTA2/TUBB4B/DNAI2/DYNC1H1/TUBB3/MYO1G/DNAH11/KIF21B/MYH9/TUBA4A/KIF21A/KIF13B/TUBA1C/MYO9B/DNAH3	0.148137164755358
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/937	36/9376	1.11182260168386	HK2/GBE1/GYS1/MGAM	0.223984179833383
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/937	46/9376	1.08765254512552	FTH1/HMOX1/CP/UGT2B7/FTL	0.198569510485943
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	8/937	76/9376	1.05330562264787	EZR/ITPR1/CA2/PRKCG/ADCY3/SLC9A1/SSTR2/ATP1A1	0.15547060287614
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/937	86/9376	1.04718175274875	KCNMA1/CREB5/PRKCG/KCNMB1/ADCY3/ATP1A1/KCNN4/RAPGEF4/KCNN1	0.146462141273742
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	12/937	116/9376	1.03514518087808	GLUL/SLC1A3/PLA2G4C/ITPR1/PRKCG/HOMER1/GLS/ADCY3/SLC38A2/GNG4/GNGT2/SLC38A1	0.126910987758144
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	9/937	87/9376	1.03514518087808	TPM2/SLC9A7/SLC8A2/SLC9A1/ATP2A2/ATP1A1/SLC8A1/CACNB2/COX7A1	0.109736440223848
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	39/937	388/9376	1.00579828142019	MT-ATP8/TUBB6/ERN1/IL1B/PTGS2/AKT3/CAPN2/IL6/ITPR1/IL1A/TUBB4B/NFKB1/EIF2AK3/PPIF/ADAM17/SLC39A10/DDIT3/DKK1/TUBB3/GAPDH/MAP2K1/LPL/SLC39A14/EIF2AK2/APOE/PSEN1/ATP2A2/WNT2B/TUBA4A/RTN4/IRS2/INSR/PIK3CB/TUBA1C/CASP8/COX7A1/BID/MME/APC2	0.0388681223536665
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	4/937	37/9376	1.08177334217889	UAP1/HK2/GFPT2/UGDH	0.166062802477821
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	15/937	148/9376	1.01416250829271	CDKN1A/HES1/AKT3/SHC3/JUN/MAP2K1/GADD45G/GADD45B/GADD45A/ESR1/FLT4/NFKB2/WNT2B/PIK3CB/APC2	0.0578664955858926
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	2/937	17/9376	1.17722393119468	PAPSS2/TXNRD1	0.243692432554727
NA	NA	hsa03272	Virion - Hepatitis viruses	5/937	48/9376	1.04233368907862	LDLR/CD9/CLDN1/CHMP1B/CHMP4B	0.0979766093721011
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/937	38/9376	1.05330562264787	PNP/CD38/NAMPT/NT5E	0.109710406521843
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/937	28/9376	1.07211465162372	ELOVL5/ELOVL7/PPT1	0.127336560186746
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/937	69/9376	1.01514237545048	KCNMA1/CTSB/ITPR1/PTGER2/AQP1/REN/ACE	0.0420652659290189
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	6/937	59/9376	1.01760034730387	UPP1/TYMP/DPYD/UPB1/NT5E/UCK2	0.045187585462847
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	2/937	18/9376	1.11182260168386	HEXB/NEU4	0.158228337407737
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	5/937	49/9376	1.02106157297497	FOSB/CREB5/NFKB1/JUN/MAOB	0.0492524450335856
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	4/937	39/9376	1.02629778616972	MAT2A/MTHFD2/DMGDH/AHCYL1	0.0548349881641179
Organismal Systems	Nervous system	hsa04730	Long-term depression	6/937	60/9376	1.00064034151547	PLA2G4C/ITPR1/PRKCG/MAP2K1/CRH/GNA12	0.00165799220714161
Human Diseases	Substance dependence	hsa05032	Morphine addiction	9/937	91/9376	0.989644293806514	PDE4A/PRKCG/PDE2A/GABRB2/ADCY3/GNG4/GNGT2/PDE4C/PDE8A	-0.0330764889097419
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/937	50/9376	1.00064034151547	SAT1/P4HA1/ALDH2/MAOB/CKB	0.00151272121029218
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	22/937	227/9376	0.969783590896055	SOD2/VEGFA/NFKBIA/MT-ATP8/AHR/AKT3/SRC/NFKB1/PPIF/HMOX1/GSTO2/ABL2/JUN/MAP2K1/MGST1/NFE2L2/PTPN1/PIK3CB/NQO1/GSTM3/COX7A1/FOXO3	-0.15356028406499
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/937	20/9376	1.00064034151547	SOAT1/HSD17B7	0.000955193791417042
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/937	20/9376	1.00064034151547	UAP1/UGDH	0.000955193791417042
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/937	31/9376	0.968361620821427	ALDH2/UGT2B7/UGDH	-0.0587916110125413
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	3/937	31/9376	0.968361620821427	GLUL/ACAT2/AFMID	-0.0587916110125413
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	6/937	63/9376	0.952990801443309	EZH2/DOT1L/ALDH2/KMT2E/ACAT2/PLOD2	-0.124743596347107
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/937	63/9376	0.952990801443309	PTGS2/PLA2G4C/PLA2G5/PTGIS/LTA4H/ALOX15B	-0.124743596347107
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	3/937	32/9376	0.938100320170758	HK2/MGAM/B4GALT1	-0.116871042271229
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	4/937	43/9376	0.930828224665558	APOA1/APOB/ACAT2/PLA2G5	-0.151482497701896
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	6/937	65/9376	0.923668007552746	NR4A1/LDLR/CREB5/ITPR1/ADCY3/PDE8A	-0.205766681640309
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	14/937	150/9376	0.933930985414443	CDKN1A/AKT3/BCL2/SHC3/JUP/MAP2K1/GADD45G/GADD45B/ABCB1/GADD45A/WNT2B/SMAD3/PIK3CB/APC2	-0.271798261153935
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	4/937	44/9376	0.909673037741341	CREB5/DYNC1H1/ADCY3/STX4	-0.200108860220098
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	2/937	22/9376	0.909673037741341	ALDH2/MAOB	-0.141331836643071
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	5/937	56/9376	0.893428876353103	BCL2/BOC/GPR161/PTCH2/CUL1	-0.266523521209586
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/937	23/9376	0.870122036100413	HMGCS1/ACAT2	-0.207794411163602
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6/937	68/9376	0.882917948396007	ALDH1A2/DHRS9/CYP2S1/UGT2B7/ALDH1A3/RDH13	-0.322869137187567
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	14/937	154/9376	0.909673037741341	KMO/ALDH2/GCH1/MAT2A/MTHFD2/KYNU/UGT2B7/GCLC/AK4/GCLM/NQO1/RDH13/AFMID/UGDH	-0.37659551765152
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	6/937	69/9376	0.870122036100413	AKT3/PLA2G4C/MAP2K1/MAP2K3/PIK3CB/FYN	-0.360798813080667
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	6/937	69/9376	0.870122036100413	FOSB/CREB5/PRKCG/JUN/MAOB/ARC	-0.360798813080667
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	4/937	47/9376	0.851608801289766	PKM/ALDH2/ACAT2/LDHA	-0.339820414841787
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/937	12/9376	0.833866951262896	NQO1	-0.191878314851765
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	4/937	48/9376	0.833866951262896	IL4I1/ALDH2/HMGCS1/ACAT2	-0.384496441821606
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	3/937	37/9376	0.811330006634169	IL4I1/MAOB/AOC3	-0.38314525255994
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/937	26/9376	0.769723339627288	PLA2G4C/PLA2G5	-0.391778619100415
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	9/937	107/9376	0.841660100340119	FOXO1/AKT3/CREB5/ITPR1/PKM/PRKAG2/GYS1/LDHA/FBP1	-0.548877910918743
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	2/937	27/9376	0.741215067789241	HMGCS1/ACAT2	-0.448691898711437
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	33/937	370/9376	0.892463007297586	FPR3/ADM/THRB/C3/C5AR1/P2RY14/OXTR/CALCRL/CHRNA5/CNR1/GABRB2/ADRA2C/CRH/CHRNE/CSH2/PTGER2/ADORA2A/KNG1/ADORA3/EDNRB/LPAR1/SSTR2/P2RX1/CYSLTR2/PTGER3/GIPR/HTR7/PRLR/ADRA2B/HTR2B/P2RX7/MC1R/ADORA2B	-0.703238628196665
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	2/937	28/9376	0.714743101082482	ST3GAL6/B4GALT1	-0.503692820527277
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/937	28/9376	0.714743101082482	CA2/ATP6V1A	-0.503692820527277
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	13/937	155/9376	0.839246738045237	CDKN1A/NR4A1/AHR/LDLR/CREB5/ITPR1/MAP2K1/ADCY3/RASD1/CRH/WNT2B/PDE8A/APC2	-0.672429212800436
NA	NA	hsa04082	Neuroactive ligand signaling	17/937	199/9376	0.854818382199149	SLC1A3/PRKCG/P2RY14/GABRB2/ADRA2C/ADCY3/GNG4/ADORA2A/GNGT2/GNAL/ADORA3/P2RX1/HTR7/ADRA2B/SLC17A9/HTR2B/ADORA2B	-0.689759584848823
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	1/937	15/9376	0.667093561010317	HEXB	-0.429948702187385
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/937	15/9376	0.667093561010317	AK4	-0.429948702187385
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5/937	66/9376	0.758060864784451	DHRS9/UGT2B7/CYP7B1/SRD5A3/HSD17B7	-0.657223662796132
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	1/937	16/9376	0.625400213447172	HEXB	-0.499688705010308
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/937	30/9376	0.667093561010317	PLA2G4C/PLA2G5	-0.608527030925253
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	17/937	205/9376	0.829799307598199	MT-ATP8/AKT3/CTSD/NFKB1/PPIF/PRKCG/GAPDH/GFPT2/MMP9/GYS1/ATP2A2/INSR/SMAD3/PIK3CB/REN/ACE/COX7A1	-0.820993741617642
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	3/937	44/9376	0.682254778306006	HEXB/MGAT1/B4GALT1	-0.703927515811839
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/937	44/9376	0.682254778306006	TAF4B/GTF2A1/TAF7	-0.703927515811839
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/937	31/9376	0.645574413880951	HSPA5/SGTA	-0.65860678495551
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	1/937	17/9376	0.588611965597338	BAAT	-0.565680662604013
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	5/937	70/9376	0.714743101082482	PTGS2/GSTO2/MGST1/UGT2B7/GSTM3	-0.798203435563779
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	6/937	83/9376	0.723354463746126	SOD2/ACSL4/BAAT/ACSL5/ACSL1/MPV17L2	-0.843518641819973
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	1/937	18/9376	0.555911300841931	TCN2	-0.62838295184727
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	11/937	142/9376	0.775143926526072	UBC/BIRC3/UBE2Q2/UBE2D1/UBE2Z/UBE2S/UBE2R2/MDM2/NEDD4/SOCS1/CUL1	-0.899629731568169
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/937	97/9376	0.722111586660652	ITPR1/PRKCG/ADCY3/GNG4/RASD1/GNGT2/ADCY10	-0.916675573765822
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/937	19/9376	0.526652811323934	OGDH	-0.688173948607109
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/937	73/9376	0.685370096928407	GSTO2/MGST1/MAOB/UGT2B7/GSTM3	-0.899207366908654
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	12/937	158/9376	0.759980006214285	CDKN1A/GADD45G/GADD45B/GADD45A/WEE1/SMAD3/YWHAH/YWHAG/MDM2/ESPL1/CUL1/CCND3	-1.01383563479108
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	2/937	36/9376	0.555911300841931	UGT2B7/UGDH	-0.88952359859599
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	3/937	51/9376	0.588611965597338	PLA2G4C/PLA2G5/PLD3	-0.981572231317481
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	21/937	268/9376	0.784083849694962	MT-ATP8/UBC/TUBB6/ERN1/DUSP1/ITPR1/TUBB4B/EIF2AK3/PPIF/SLC39A10/DDIT3/TUBB3/SLC39A14/MAOB/NFE2L2/ADORA2A/HSPA5/GNAL/TUBA4A/TUBA1C/COX7A1	-1.19495335951415
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/937	79/9376	0.633316671845237	GSTO2/MGST1/CYP2S1/UGT2B7/GSTM3	-1.09054410598065
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	1/937	23/9376	0.435061018050206	B4GALT1	-0.903857433339356
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	4/937	67/9376	0.597397218815209	ITPR1/PRKCG/MAP2K1/RPS6KA3	-1.10197716968961
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	10/937	144/9376	0.694889126052413	ERN1/AKT3/ITPR1/PPIF/PRKCG/KCNC3/RELN/ATP2A2/PIK3CB/RORA	-1.22942198259378
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	2/937	41/9376	0.488117239763646	RBBP8/NBN	-1.09449860042672
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/937	56/9376	0.536057325811862	MGAT1/B4GALT1/SRD5A3	-1.16027335485089
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	14/937	195/9376	0.718408450318803	FPR3/AKT3/VWF/C3/SRC/C5AR1/NFKB1/PPIF/PRKCG/AQP9/MAP2K1/ITGB3/PIK3CB/AZU1	-1.32404233064061
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	7/937	110/9376	0.636771126418939	HSP90AA1/AKT3/HSP90AB1/MAP2K1/ADCY3/PIK3CB/RPS6KA3	-1.2768518167676
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/937	26/9376	0.384861669813644	HES1	-1.04655871405327
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	10/937	149/9376	0.671570699003674	PTGS2/MGLL/ITPR1/PRKCG/CNR1/GABRB2/ADCY3/GNG4/GNGT2/DAGLA	-1.34652589611837
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	6/937	101/9376	0.594439806840876	PRKCG/MAP2K1/ADCY3/WNT2B/EDNRB/MC1R	-1.36542858087921
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	1/937	28/9376	0.357371550541241	GCH1	-1.1347222012413
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	38/937	480/9376	0.792173603699751	MT-ATP8/UBC/TUBB6/ERN1/IL1B/GPX3/PTGS2/BCL2/CAPN2/IL6/ITPR1/IL1A/TUBB4B/NFKB1/EIF2AK3/PPIF/PRKCG/DNAI2/DDIT3/DKK1/TUBB3/MAP2K1/DNAH11/MAP2K3/PSEN1/ATP2A2/HSPA5/WNT2B/TUBA4A/TUBA1C/CASP8/SQSTM1/TANK/MAP1LC3B/COX7A1/BID/DNAH3/APC2	-1.55752088470885
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	1/937	30/9376	0.333546780505158	OGDH	-1.21822455624639
NA	NA	hsa04981	Folate transport and metabolism	1/937	31/9376	0.322787206940476	ABCC3	-1.25842195889848
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	8/937	133/9376	0.601888927227353	AKT3/CREB5/ITPR1/PRKCG/GNG4/MAOB/GNGT2/GNAL	-1.54075484145007
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	4/937	79/9376	0.50665333747619	SLC1A3/STX3/ATP6V1A/ATP6V1H	-1.46725049575608
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	1/937	32/9376	0.312700106723586	LDHA	-1.29767157280468
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	1/937	32/9376	0.312700106723586	GABARAPL1	-1.29767157280468
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	16/937	235/9376	0.681287041031813	MT-ATP8/CREB5/MGLL/PRKAG2/ACSL4/CNR1/ADCY3/MAP2K3/ACSL5/ACSL1/ADCY10/RPS6KA3/ZNF516/BMP8A/COX7A1/RHEB	-1.64871936607204
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	1/937	33/9376	0.30322434591378	OGDH	-1.33603151731566
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	27/937	368/9376	0.734165467959724	MT-ATP8/TUBB6/ERN1/GPX3/BCL2/TUBB4B/EIF2AK3/DNAI2/NXF1/DDIT3/TUBB3/DNAH11/MAP2K3/MATR3/HSPA5/TUBA4A/TUBA1C/SQSTM1/ANG/TANK/NUP210L/NRG2/MAP1LC3B/COX7A1/BID/DNAH3/NUP98	-1.73352877972326
NA	NA	hsa04519	Cadherin signaling	30/937	404/9376	0.743049758551095	VIM/NFKBIA/DES/MRAS/ACTN1/PTK2B/LHFPL2/NFKB1/CDH13/TEAD1/LATS2/JUP/MYO1G/MAP2K1/GABRB2/MAP2K3/FLT4/PSEN1/WNT2B/VCL/YWHAH/YWHAG/CELSR1/PCDH7/CDH23/PRICKLE2/SAV1/TAOK3/ACTR3C/APC2	-1.75915869972885
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	8/937	138/9376	0.580081357400275	ITPR1/MAP2K1/ADCY3/RPS6KA3/YWHAH/YWHAG/ESPL1/CUL1	-1.65586779771469
NA	NA	hsa04382	Cornified envelope formation	14/937	217/9376	0.645574413880951	DST/PLEC/LAMB3/S100A10/JUP/ST14/CLDN1/LAMA3/S100A8/S100A16/TCHH/S100A4/PCSK6/UGCG	-1.7601141884852
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	2/937	54/9376	0.37060753389462	HES1/POLH	-1.54551708683176
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	1/937	41/9376	0.244058619881823	GABRB2	-1.61634039435507
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	5/937	108/9376	0.463259417368275	NXF1/EIF4A3/NUP210L/RANGAP1/NUP98	-1.86936126163876
Human Diseases	Substance dependence	hsa05034	Alcoholism	11/937	191/9376	0.576285013438232	FOSB/CREB5/SHC3/MAP2K1/GNG4/CRH/MAOB/ADORA2A/GNGT2/CAMKK2/ADORA2B	-1.97133697855261
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	20/937	308/9376	0.649766455529529	SOD2/MT-ATP8/SLC1A3/TUBB6/ERN1/GPX3/TAF4B/CREB5/TGM2/ITPR1/TUBB4B/PPIF/DNAI2/TUBB3/DNAH11/TUBA4A/TUBA1C/CASP8/COX7A1/DNAH3	-2.0825108945546
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	1/937	44/9376	0.227418259435335	APTX	-1.71156482699532
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	1/937	46/9376	0.217530509025103	PSMB9	-1.77261919286631
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	4/937	103/9376	0.388598190879796	NXF1/PABPC4/PABPC1/EIF4A3	-2.07895525468075
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	4/937	117/9376	0.342099262056573	BAZ1A/GATAD2A/RUVBL2/CHD3	-2.38605913352642
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	4/937	138/9376	0.290040678700138	MT-ATP8/ATP6V1A/COX7A1/ATP6V1H	-2.79958701178319
Organismal Systems	Sensory system	hsa04742	Taste transduction	1/937	86/9376	0.116353528083195	TAS1R1	-2.74302557378697
Genetic Information Processing	Transcription	hsa03040	Spliceosome	9/937	243/9376	0.37060753389462	HSPA6/HSPA1A/HSPA1B/HSPA1L/HSPA8/EIF4A3/HNRNPC/PRPF4/SNIP1	-3.31228645194755
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	5/937	183/9376	0.273399000414064	NXF1/NOP58/TCOF1/GTPBP4/GNL2	-3.30752279519854
Genetic Information Processing	Translation	hsa03010	Ribosome	1/937	222/9376	0.0450738892574538	MRPL18	-4.79789502775253
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	6/937	449/9376	0.133715858554406	PDE2A/ADCY3/SLC8A2/GNAL/RGS2/SLC8A1	-6.26816914687423