category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	60/1105	169/9376	3.01245013253367	PIK3R1/AKT3/IGF1R/PTEN/CTSB/LAMP2/NBR1/WIPI2/MAP1LC3B/RAF1/VPS41/SQSTM1/TBK1/RHEB/PIK3C3/PRKAA1/MAP1LC3C/OPTN/BCL2L1/MAPK8/WIPI1/CFLAR/ATG2B/MTMR14/ATG9A/PDPK1/DAPK1/UBC/RPS6KB1/RAB1A/C9orf72/RPTOR/EPG5/IRS2/BCL2/SUPT20H/GABARAPL1/WDR45/CALCOCO2/ATG12/ATG5/AKT1S1/RRAGB/BNIP3/STK11/PLEKHM1/EIF2AK3/WDFY3/DEPTOR/RRAGC/VPS39/ATG4D/DAPK3/BECN1/ATG13/MTMR3/RUBCN/CAMKK2/SMCR8/MTOR	9.64933035332482
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	44/1105	142/9376	2.62917596074183	CUL3/PIAS1/UBE2D2/UBE3A/UBA2/HERC2/UBE2K/RCHY1/SMURF2/UBE2R2/UBE2B/NEDD4L/HERC1/CUL4A/BTRC/SIAH1/ITCH/NEDD4/DDB1/UBA1/MDM2/HERC4/UBE2G1/UBE4A/UBC/UBE3C/HERC3/UBE2Q2/TRIP12/CUL1/HUWE1/ANAPC4/UBE2Q1/SYVN1/KEAP1/WWP2/UBE2D1/UBE2Z/SMURF1/SAE1/UBE2G2/UBR5/SOCS1/PPIL2	7.14998280098737
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	31/1105	83/9376	3.16912173581203	USP16/UBE2D2/SUZ12/PCGF3/EZH1/PHC3/USP7/JARID2/YAF2/RBBP4/KDM2A/SCMH1/AEBP2/CREBBP/L3MBTL4/MGA/ASXL2/RYBP/EP300/FOXK2/CBX4/SCML1/MBD6/ASXL1/FOXK1/PHC2/WDR5/FBRSL1/UBE2D1/SFMBT2/AUTS2	7.25492238583951
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	33/1105	105/9376	2.66673561732385	FOXO3/NBR1/FKBP8/USP8/MAP1LC3B/BCL2L13/SQSTM1/TBK1/SMURF2/MAP1LC3C/ATF4/OPTN/CSNK2A2/BCL2L1/MAPK8/SIAH1/PINK1/ATG9A/UBC/GABARAPL1/CALCOCO2/BNIP3/AMFR/TBC1D17/HUWE1/RAB5B/EIF2AK3/TOMM40/BECN1/BNIP3L/SMURF1/RELA/TBC1D15	6.27748728857454
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	37/1105	133/9376	2.36050760385126	FOXO1/FBXO32/INSR/FOXO3/PIK3R1/AKT3/IGF1R/PTEN/RAF1/BRAF/SMAD4/PRKAG2/PRKAA1/SETD7/TGFB2/DEPP1/MAPK8/USP7/STK4/SIRT1/MDM2/CREBBP/SGK1/PDPK1/CSNK1E/IRS2/GABARAPL1/ATG12/GADD45G/EP300/TGFBR1/IKBKB/BNIP3/STK11/ARAF/TGFB1/HOMER1	5.77574597522949
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	28/1105	93/9376	2.55464409088698	INSR/IGF1R/PTPN1/SNAI2/SMAD4/CTNND1/RAP1A/RAP1B/TJP1/NECTIN2/CTNNB1/SSX2IP/SMURF2/TCF7L2/CSNK2A2/FER/FGFR1/CREBBP/WASF3/EP300/TGFBR1/MYL9/YES1/SMURF1/ERBB2/CTNNA1/IQGAP1/BAIAP2	5.50701229781178
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	55/1105	250/9376	1.8667149321267	HLA-G/ASAP1/IGF1R/RAB11FIP3/RAB11B/PDCD6IP/WASHC4/PDGFRA/USP8/PIP5K1A/HSPA1A/SPART/TSG101/AP2A1/IST1/CYTH1/STAM/ARFGAP3/ARFGEF2/ARFGEF1/EPN2/CLTCL1/CLTB/CYTH3/SMURF2/RAB11FIP1/NEDD4L/RUFY2/LDLR/ARF1/ITCH/NEDD4/HGS/SMAD2/MDM2/PRKCI/STAM2/TGFBR1/GBF1/ZFYVE9/RAB31/CHMP4B/HLA-E/WASHC2A/RAB5B/CAV1/WIPF2/IQSEC1/GRK5/CHMP1A/SMURF1/RAB35/ARFGAP1/VPS37C/IQSEC3	5.07684398870292
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	27/1105	90/9376	2.54552036199095	FOXO1/INSR/FOXO3/PIK3R1/SESN1/AKT3/IGF1R/EIF4EBP1/ADIPOR1/EHMT1/PRKAG2/CREB3L1/RHEB/PRKAA1/ATF4/SIRT1/RPS6KB1/RPTOR/IRS2/ATG5/AKT1S1/STK11/RELA/ATG13/CREB3/CAMKK2/MTOR	5.38479796040919
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	33/1105	122/9376	2.29514130999184	FOXO1/INSR/FOXO3/PIK3R1/AKT3/IGF1R/EIF4EBP1/RAB11B/ADIPOR1/PPP2R5E/PRKAG2/RAB2A/CREB3L1/RHEB/PRKAA1/PPP2R2D/SIRT1/PDPK1/FASN/RPS6KB1/PPP2R3C/RPTOR/IRS2/PPP2R2A/AKT1S1/EEF2/STK11/HMGCR/PPP2R5A/MLYCD/CREB3/CAMKK2/MTOR	5.26283907409884
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	42/1105	174/9376	2.04811983148697	GANAB/RPN1/OS9/SELENOS/ATXN3/XBP1/UBE2D2/CANX/HSPA1A/SEC31A/SEL1L/UBQLN1/SAR1A/ATF4/SSR3/MAGT1/MAPK8/NFE2L2/DERL1/DNAJA1/STT3B/UBE2G1/RNF5/SEC24A/BCL2/ERO1B/RAD23B/SEC23A/BCAP29/AMFR/MAP2K7/ATF6/CUL1/NGLY1/DNAJB2/EIF2AK3/SYVN1/RNF185/UGGT1/UBE2D1/UBE2G2/UBQLN2	5.10072858424626
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	53/1105	253/9376	1.77750433709513	FOXO1/FOXO3/PIK3R1/AKT3/CASP4/WIPI2/MAP1LC3B/UBE2D2/CD44/TAB2/CYTH1/DOCK1/SQSTM1/TBK1/PIK3C3/CYTH3/MAP1LC3C/BCL2L1/MAPK8/ARF1/BTRC/WIPI1/HK1/MDM2/UBC/RPS6KB1/GSK3A/RPTOR/ITGA5/BCL2/MALT1/CALCOCO2/BCL10/ATG12/ATG5/AKT1S1/CAST/RRAGB/IKBKB/BNIP3/NOD1/PXN/CUL1/MYL9/RRAGC/NFKBIB/IL18/NFKBIA/BECN1/UBE2D1/RELA/PLCE1/MTOR	4.58228408374346
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	13/1105	32/9376	3.44705882352941	WIPI2/PIK3C3/WIPI1/ATG2B/ATG9A/RPTOR/GABARAPL1/ATG12/ATG5/ATG4D/BECN1/ATG13/MTOR	5.06804835993434
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	27/1105	103/9376	2.2242410930018	PAPOLA/PPP2R5E/WDR82/FUS/RNPS1/CPSF6/DAZAP1/TARDBP/UPF2/PCF11/SMG6/PPP2R2D/CASC3/SMG1/PPP2R3C/HBS1L/PPP2R2A/NXF1/ACIN1/GSPT1/PELO/SMG5/PPP2R5A/DDX19A/PABPC4/DDX19B/PAPOLG	4.56628697872509
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	37/1105	163/9376	1.92605835160869	PIK3R1/JAK2/AKT3/YWHAQ/RAF1/BRAF/TAB2/SMAD4/IFNAR1/CREB3L1/TBK1/ATF4/TGFB2/MAPK8/MAVS/FOS/NFATC4/DDB1/CREBBP/BCL2/MYC/EP300/TGFBR1/IKBKB/STAT6/ARAF/MAP2K4/MAP2K7/NFATC2/TGFB1/HSPG2/DDX3X/NFKBIA/RELA/STAT1/TICAM1/CREB3	4.35932638587864
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	13/1105	34/9376	3.24429065743945	CSNK1D/RORA/PRKAG2/PRKAA1/BTRC/FBXL3/CRY1/CSNK1E/CRY2/RORB/NFIL3/CUL1/PER1	4.7916644245113
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	27/1105	106/9376	2.16129087338854	FOXO1/PDGFD/PIK3R1/AKT3/IGF1R/PTEN/PDGFRA/RAF1/BRAF/CTNNB1/CREB3L1/ATF4/TCF7L2/FGFR1/MDM2/CREBBP/PDPK1/BCL2/EP300/IKBKB/ARAF/NFKBIA/RELA/ERBB2/AR/CREB3/MTOR	4.39482762034312
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	50/1105	248/9376	1.71069916800467	AKT3/SNX18/CASP4/PIK3C2A/RAF1/ARHGEF26/GCC2/TAB2/CYTH1/KPNA4/VPS41/CTNNB1/PLEKHM2/PIK3C3/CYTH3/TUBA1C/TCF7L2/ARL8A/MAPK8/FOS/ARF1/TUBB4B/ARL8B/FLNA/WASF3/BCL2/MYC/KPNA1/IKBKB/EXOC5/NOD1/PLEKHM1/MAP2K4/MAP2K7/DYNC2H1/TUBB6/RAB5B/MYL9/RHOB/NCKAP1/ANXA2/VPS39/DCTN5/IL18/DYNC1I2/NFKBIA/FYCO1/RELA/ABI1/TUBB2A	4.14583103747103
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	15/1105	44/9376	2.89263677498972	GTF2F2/TAF15/CCNH/GTF2H1/TAF13/TAF3/TAF2/TAF5L/GTF2E2/GTF2A1/TAF1/TAF8/GTF2F1/CDK7/TAF4	4.5993241039583
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	22/1105	80/9376	2.33339366515837	VEGFA/PDGFD/FOXO3/PIK3R1/JAK2/AKT3/IGF1R/PTEN/EIF4EBP1/PDGFRA/RAF1/IL6R/BRAF/BCL2L1/RPS6KB1/NRG2/BCL2/ARAF/GAB1/FGF2/ERBB2/MTOR	4.37767070595172
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	35/1105	157/9376	1.89157564054529	SERPINE1/IGFBP3/FOXO1/FOXO3/PIK3R1/HIPK3/HLA-G/AKT3/PTEN/EIF4EBP1/RAF1/TRPM7/RAD50/SQSTM1/RHEB/TGFB2/GATA4/BTRC/NFATC4/SMAD2/RBBP4/LIN52/SIRT1/MDM2/MCU/PPP3CC/MYC/GADD45G/TGFBR1/NFATC2/TGFB1/HLA-E/RAD9A/RELA/MTOR	4.11769220054753
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	35/1105	158/9376	1.87960364282032	INSR/PIK3R1/AKT3/IGF1R/PTEN/EIF4EBP1/ATP6V1E1/RAF1/BRAF/SLC3A2/LPIN2/LPIN1/RHEB/PRKAA1/FZD6/RICTOR/SLC38A9/SGK1/PDPK1/RPS6KB1/RPTOR/AKT1S1/FNIP1/RRAGB/WDR59/IKBKB/STK11/DEPTOR/RRAGC/RNF152/FLCN/FNIP2/TTI1/CASTOR2/MTOR	4.07553828954752
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	21/1105	77/9376	2.31410941999177	VEGFA/PIK3R1/AKT3/RAF1/BRAF/POLK/SMAD4/TGFB2/BCL2L1/MAPK8/SMAD2/RPS6KB1/GADD45G/TGFBR1/IKBKB/ARAF/TGFB1/RELA/STAT1/ERBB2/MTOR	4.23200852630683
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	21/1105	78/9376	2.2844413505047	PTEN/PIK3C2A/INPP5K/IP6K2/PIP5K1A/PIK3C3/PI4KA/IP6K1/CDIPT/IP6K3/MTMR14/PIP4K2A/ALDH6A1/MTM1/MTMR2/ITPK1/ITPKC/INPP1/PLCE1/MTMR3/INPP5A	4.16346171764104
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	26/1105	108/9376	2.04270152505447	TPR/KPNA6/RANBP2/KPNA4/RNPS1/NUP58/NUP98/AHCTF1/UPF2/IPO7/SENP2/CASC3/NUP50/NXF1/NUP153/NUP93/KPNA1/ACIN1/NUP155/NUP85/DDX19A/DDX19B/IPO11/NUP88/XPOT/RANGAP1	3.98351668656072
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	31/1105	138/9376	1.90606597153912	FOXO1/INSR/PIK3R1/AKT3/PRKAR2B/EIF4EBP1/PTPN1/RAF1/BRAF/SOCS2/PRKAG2/PRKAR2A/RHEB/PRKAA1/MAPK8/TRIP10/HK1/RAPGEF1/PRKCI/MKNK2/PDPK1/FASN/RPS6KB1/RPTOR/IRS2/RHOQ/IKBKB/ARAF/SOCS1/INPP5A/MTOR	3.91920654102714
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	22/1105	86/9376	2.17059875828686	PIK3R1/AKT3/EIF4EBP1/RAF1/BRAF/NCK1/ABL1/PAK2/CAMK2D/MAPK8/RPS6KB1/NRG2/MYC/EREG/ARAF/MAP2K4/MAP2K7/GAB1/ABL2/ERBB2/HBEGF/MTOR	3.98599908364501
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	26/1105	110/9376	2.0055614973262	TF/THBS1/FBN1/INHBA/SMAD4/SMURF2/BMPR2/TGFB2/SMAD2/CREBBP/SKIL/RPS6KB1/TGIF1/MYC/EP300/TGFBR1/ID4/ZFYVE9/BMP2/CUL1/TGFB1/SIN3A/ACVR1B/LEMD3/SMURF1/LEFTY2	3.8774534923418
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	41/1105	204/9376	1.70533226865407	FN1/VEGFA/PIK3R1/THBS1/TIMP3/AKT3/IGF1R/RAF1/BRAF/CD44/FRS2/ARHGEF12/CTNNB1/CAMK2D/TGFB2/FZD6/FGFR1/SMAD2/MDM2/VAV2/PDPK1/FLNA/RPS6KB1/SDC1/ITGA5/MYC/ARAF/PXN/TGFB1/HSPG2/GPC1/GAB1/CAV1/ARHGEF1/ITGAV/FGF2/ERBB2/PLCE1/IQGAP1/HBEGF/MTOR	3.72275607125722
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	19/1105	73/9376	2.2084423231885	ELL2/PDCD6IP/AFF4/TSG101/RANBP2/CCNT2/SERINC3/CPSF6/HGS/FURIN/SAMHD1/ELL/NELFE/CREBBP/NUP153/EP300/CHMP4B/SUPT5H/NELFB	3.78846791503241
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	17/1105	62/9376	2.32655086848635	FOXO1/INSR/FOXO3/PIK3R1/AKT3/IGF1R/EIF4EBP2/HSPA1A/PRKAG2/PRKAA1/SIRT1/RPS6KB1/RPTOR/IRS2/ATG5/AKT1S1/MTOR	3.83035832040823
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	33/1105	157/9376	1.7834856039427	SERPINE1/TEAD1/LLGL2/CSNK1D/NKD1/YWHAQ/SNAI2/SMAD4/LATS2/CTNNB1/BMPR2/TGFB2/TCF7L2/FZD6/BTRC/SMAD2/PPP2R2D/YWHAG/PRKCI/CSNK1E/YAP1/PPP2R2A/MYC/TEAD3/TGFBR1/DLG5/TP53BP2/BMP2/SAV1/TGFB1/WTIP/AJUBA/CTNNA1	3.61848441554887
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	39/1105	196/9376	1.68835534213685	VEGFA/PIK3R1/JAK2/HLA-G/AKT3/PTGS2/MAP1LC3B/IL6ST/RAF1/IFNGR1/IFNAR1/ZFP36/CTNNB1/TBK1/PIK3C3/MAP1LC3C/TCF7L2/MAPK8/FOS/NFATC4/RCAN1/CREBBP/PPP3CC/UBC/MYC/EP300/IKBKB/MAP2K4/MAP2K7/NFATC2/HLA-E/NFKBIA/BECN1/FGF2/RELA/STAT1/TICAM1/GNG12/MTOR	3.55964877624842
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	15/1105	52/9376	2.44761573268361	APOA2/APOC3/APOB/APOA1/APOC2/APOH/NPC1/STARD3/VAPA/LDLR/ABCA1/SOAT1/APOC1/LCAT/SCARB1	3.82597035438343
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	23/1105	98/9376	1.99139348046911	PIK3R1/PTEN/PIK3C2A/IP6K2/PIP5K1A/PIK3C3/PI4KA/IP6K1/CDIPT/IP6K3/MTMR14/PIP4K2A/DGKD/MTM1/CDS2/MTMR2/ITPK1/PIP4P1/ITPKC/INPP1/PLCE1/MTMR3/INPP5A	3.60594982266109
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	25/1105	110/9376	1.92842451665981	SERPINE1/VEGFA/TF/FLT1/INSR/PIK3R1/AKT3/ALDOB/IGF1R/EIF4EBP1/IFNGR2/IFNGR1/IL6R/PGK1/CAMK2D/HK1/MKNK2/CREBBP/RPS6KB1/BCL2/EP300/EGLN3/RELA/ERBB2/MTOR	3.58001265369702
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	21/1105	87/9376	2.04811983148697	PIK3R1/AKT3/RAF1/BRAF/POLK/SMAD4/CTNNB1/TGFB2/TCF7L2/MAPK8/FOS/SMAD2/RPS6KB1/BCL2/MYC/GADD45G/TGFBR1/EREG/ARAF/TGFB1/MTOR	3.58982973057752
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	19/1105	77/9376	2.09371804665922	PIK3R1/AKT3/RAF1/BRAF/POLK/SMAD4/ABL1/TGFB2/BCL2L1/MDM2/MYC/GADD45G/TGFBR1/IKBKB/ARAF/TGFB1/NFKBIA/GAB2/RELA	3.52225166977835
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	24/1105	109/9376	1.86827182531446	FOXO1/INSR/PIK3R1/AKT3/PTEN/PTPN1/PRKAG2/CREB3L1/PRKAA1/SLC2A2/PPARA/NR1H2/MAPK8/PDPK1/RPS6KB1/IRS2/IKBKB/OGA/TRIB3/GFPT1/NFKBIA/RELA/CREB3/MTOR	3.33263033414901
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	26/1105	122/9376	1.8082931533269	FOXO1/PIK3R1/AKT3/NCOA1/RAF1/MED13/CTNNB1/RHEB/DIO3/GATA4/MED13L/MDM2/RCAN1/CREBBP/PDPK1/NOTCH2/MYC/EP300/ATP1A1/SIN3A/ITGAV/MED17/STAT1/PLCE1/NCOA2/MTOR	3.2845194248975
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	23/1105	104/9376	1.87650539505743	PLA2G5/PLA2G2A/PLA2G4A/LPGAT1/CHPT1/LPIN2/LPIN1/CDIPT/AGPAT4/CRLS1/CHKA/GPAT4/PLPP1/DGKD/GPAT3/CDS2/PISD/SELENOI/MBOAT7/PLA2G6/PNPLA7/GPD2/LCAT	3.28527946112684
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	33/1105	168/9376	1.66670976082741	PRLR/PIK3R1/JAK2/AKT3/IL15RA/IFNGR2/PIAS1/PDGFRA/IL6ST/RAF1/IFNGR1/IL6R/SOCS2/OSMR/STAM/IFNAR1/CISH/BCL2L1/PIM1/CREBBP/IL13RA1/STAM2/BCL2/MYC/EP300/STAT6/MCL1/CSF2RB/STAT1/CSH2/IL20RB/SOCS1/MTOR	3.18710642417998
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	61/1105	362/9376	1.42980425489363	FN1/VEGFA/FLT1/PRLR/PDGFD/INSR/FOXO3/PIK3R1/THBS1/JAK2/AKT3/LPAR1/LAMB1/IGF1R/PTEN/EIF4EBP1/TNC/PDGFRA/PHLPP1/YWHAQ/PPP2R5E/RAF1/IL6R/OSMR/IFNAR1/CREB3L1/RHEB/PRKAA1/ATF4/BCL2L1/FGFR1/LAMC3/PPP2R2D/MDM2/YWHAG/SGK1/PDPK1/RPS6KB1/PPP2R3C/RPTOR/ITGA5/BCL2/PPP2R2A/MYC/IKBKB/THBS2/EREG/STK11/F2R/ITGAV/MCL1/COL6A3/PPP2R5A/FGF2/RELA/ERBB2/CSH2/CREB3/GNG12/MTOR/COL4A1	3.04827388697886
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	38/1105	203/9376	1.5883378285001	FN1/VEGFA/FLT1/PDGFD/PIK3R1/THBS1/AKT3/LAMB1/IGF1R/PTEN/TNC/PDGFRA/RAF1/BRAF/PIP5K1A/DOCK1/RAP1A/RAP1B/CTNNB1/PAK2/MAPK8/LAMC3/EMP2/RAPGEF1/VAV2/PDPK1/FLNA/ITGA5/BCL2/ARHGAP35/THBS2/PXN/CAV1/MYL9/ITGAV/COL6A3/ERBB2/COL4A1	3.09746824147125
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	24/1105	112/9376	1.81822882999354	JAK2/AKT3/LAMB1/IFNGR2/IFNGR1/HSPA1A/TAB2/TGFB2/LDLR/BCL2L1/MAPK8/LAMC3/PPIF/PDPK1/BCL2/GNAI1/IKBKB/TGFB1/HLA-DRB5/NFKBIB/NFKBIA/RELA/STAT1/SOCS1	3.18399430725648
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	17/1105	70/9376	2.06065934065934	JAK2/AKT3/ADIPOR1/PRKAG2/PRKAA1/PPARA/MAPK8/ACSL3/ACSL1/IRS2/IKBKB/STK11/NFKBIB/NFKBIA/RELA/CAMKK2/MTOR	3.25560107806247
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	17/1105	70/9376	2.06065934065934	VEGFA/PIK3R1/AKT3/RAF1/BRAF/RAP1A/RAP1B/PAK2/TGFB2/RAPGEF1/CREBBP/EP300/ARAF/TGFB1/GAB1/FLCN/EGLN3	3.25560107806247
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	15/1105	59/9376	2.15722064575504	FOXO3/PIK3R1/AKT3/PTEN/RAF1/BRAF/POLK/CTNNB1/TCF7L2/PDPK1/MYC/GADD45G/ARAF/ERBB2/CTNNA1	3.25905656373293
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	20/1105	90/9376	1.88557063851182	PIK3R1/JAK2/AKT3/PTEN/IFNGR2/RAF1/IFNGR1/CSNK2A2/FOS/PPP3CC/RPS6KB1/MAP3K3/IKBKB/NFATC2/NFKBIB/NFKBIA/RELA/STAT1/TICAM1/MTOR	3.0854455789335
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	23/1105	109/9376	1.79042716592636	JAK2/IFNGR2/RORA/IL6ST/IFNGR1/IL6R/SMAD4/MAPK8/FOS/SMAD2/PPP3CC/TGFBR1/IKBKB/STAT6/NFATC2/TGFB1/HLA-DRB5/NFKBIB/NFKBIA/AHR/RELA/STAT1/MTOR	3.03384432536158
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	22/1105	103/9376	1.81234459429776	SERPINE1/PIK3R1/AKT3/IFNGR2/IFNGR1/KNG1/TGFB2/MAPK8/FOS/SMAD2/PPP2R2D/CFLAR/GNA11/PPP2R2A/TGFBR1/GNAI1/IKBKB/MAP2K4/TGFB1/NFKBIA/RELA/TICAM1	3.02995755034187
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	16/1105	68/9376	1.99648655842427	ZBTB16/PIK3R1/AKT3/EIF4EBP1/PPARD/RAF1/BRAF/TCF7L2/PIM1/RPS6KB1/JUP/MYC/IKBKB/ARAF/RELA/MTOR	3.01429310922021
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	15/1105	63/9376	2.02025425554837	ERCC1/CCNH/XPC/CUL4A/GTF2H1/DDB1/ERCC5/RAD23B/RPA1/POLR2M/RPA2/ERCC6/CDK7/POLE3/POLD3	2.96976206218593
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	36/1105	200/9376	1.52731221719457	LPAR1/CASP4/NCL/TMED10/NCK1/TAB2/CYTH1/ABL1/ARHGEF12/TJP1/PAK2/CYTH3/TUBA1C/MAPK8/FOS/ARF1/MYH11/TUBB4B/WASF3/RAB1A/SEC24A/IKBKB/TUBB6/F2R/WIPF2/NCKAP1/ARHGEF1/CLDN11/NFKBIB/IL18/NFKBIA/RELA/MYO1E/BAIAP2/ABI1/TUBB2A	2.75514141899919
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	11/1105	41/9376	2.27648162454475	VEGFA/THBS1/RAF1/BRAF/MDM2/DAPK1/MYC/ARAF/DAPK3/ERBB2/HBEGF	2.99389869770475
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	50/1105	300/9376	1.41417797888386	VEGFA/FLT1/PDGFD/INSR/AKT3/DUSP1/IGF1R/MAP3K2/HSPB1/PDGFRA/RAF1/BRAF/PLA2G4A/HSPA1A/TAB2/TAOK3/RAP1A/RAP1B/PAK2/ATF4/TGFB2/MAPK8/FOS/PPP5C/STK4/FGFR1/MKNK2/PPP3CC/PPM1A/FLNA/PPM1B/CACNA1C/MYC/GADD45G/TGFBR1/MAP3K3/IKBKB/EREG/ARAF/MAP2K4/MAP2K7/TGFB1/RASA1/MAP3K12/FGF2/RELA/ERBB2/SRF/GNG12/ELK4	2.66494441522949
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	39/1105	224/9376	1.47731092436975	PIK3R1/HLA-G/AKT3/PTEN/IL15RA/CRTC1/CANX/SMAD4/ZFP36/CREB3L1/ATF4/TGFB2/BCL2L1/MAPK8/FOS/NFATC4/SMAD2/GPS2/TRRAP/CREBBP/PPP3CC/ETS2/MYC/EP300/TGFBR1/MAP3K3/IKBKB/MAP2K4/NFATC2/TGFB1/HLA-E/ANAPC4/HLA-DRB5/NFKBIA/RELA/SRF/FOSL1/CREB3/ELK4	2.64274429857945
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	31/1105	170/9376	1.54727708277881	PIK3R1/AKT3/IGF1R/PTEN/RAF1/SMARCD2/BRAF/POLK/SMAD4/CTNNB1/TGFB2/TCF7L2/FZD6/BCL2L1/NFE2L2/SMARCC1/SMAD2/RPS6KB1/MYC/GADD45G/TGFBR1/MGST1/ARAF/TGFB1/GAB1/GSTM3/ARID1B/KEAP1/PHF10/CSNK1A1/MTOR	2.63198860472638
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	54/1105	333/9376	1.37595695242754	FN1/FOXO1/VEGFA/PIK3R1/THBS1/HLA-G/AKT3/LAMB1/PTEN/EIF4EBP1/PTGS2/TNC/LLGL2/JAG1/UBE3A/ATP6V1E1/PPP2R5E/RAF1/IFNAR1/CTNNB1/CREB3L1/CHD4/TBK1/RHEB/TCF7L2/FZD6/HEYL/LAMC3/NFX1/PPP2R2D/MDM2/PRKCI/CREBBP/RPS6KB1/PPP2R3C/ITGA5/NOTCH2/PPP2R2A/EP300/IKBKB/THBS2/PXN/HLA-E/MAML1/ITGAV/COL6A3/PPP2R5A/RELA/STAT1/TICAM1/CREB3/CSNK1A1/MTOR/COL4A1	2.55324058190038
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	23/1105	117/9376	1.66800479560661	BAZ2B/SMARCD2/SS18/SMARCA5/CHD4/BAZ1B/SMARCA1/SMARCC1/RBBP4/TRRAP/INO80/BAZ1A/EP400/ACTR6/CHRAC1/GATAD2A/BCL7B/MBD2/ARID1B/GATAD2B/PHF10/BCL7A/POLE3	2.65753036761392
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	32/1105	180/9376	1.50845651080945	PIK3R1/JAK2/HLA-G/AKT3/EIF4EBP1/IFNGR2/SRSF4/IFNGR1/TAB2/IFNAR1/NECTIN2/TBK1/RHEB/PILRB/BCL2L1/MAVS/SRPK1/ITGA5/BCL2/NXF1/HCFC2/IKBKB/HLA-E/EIF2B4/HLA-DRB5/NFKBIA/EIF2B5/RELA/STAT1/TICAM1/ZC3HAV1/MTOR	2.51755142757756
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	13/1105	56/9376	1.96974789915966	CUL3/MOSMO/CSNK1D/SPOP/SMURF2/BTRC/CSNK1E/BCL2/SPOPL/CSNK1G3/CUL1/SMURF1/CSNK1A1	2.66031260094095
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	23/1105	120/9376	1.62630467571644	FOXO3/PIK3R1/AKT3/ARHGDIA/RAF1/BRAF/FRS2/ABL1/RAP1A/RAP1B/CAMK2D/ATF4/MAPK8/RAPGEF1/PDPK1/BCL2/MAP3K3/IKBKB/MAP2K7/GAB1/NFKBIB/NFKBIA/RELA	2.52378509298223
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	22/1105	115/9376	1.62323037576235	AKAP13/RAF1/BRAF/RUNX2/CREB3L1/ATF4/FOS/FGFR1/MEF2D/MAFB/GNA11/SGK1/BCL2/GNAI1/STK39/ARAF/OXSR1/ARHGEF1/WNK3/CREB3/HBEGF/VDR	2.45785555983483
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	23/1105	122/9376	1.59964394332765	PIK3R1/AKT3/PPP2R5E/RAF1/NCK1/PAK2/MAPK8/FOS/PPP2R2D/VAV2/PDPK1/PPP3CC/PPP2R3C/PPP2R2A/MALT1/BCL10/IKBKB/MAP2K7/NFATC2/NFKBIB/NFKBIA/PPP2R5A/RELA	2.43666814666836
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	8/1105	29/9376	2.34070837884225	TEAD1/LATS2/CSNK1E/YAP1/TEAD3/SAV1/WTIP/AJUBA	2.64292578437977
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	15/1105	71/9376	1.79261997323306	PRLR/FOXO3/PIK3R1/JAK2/AKT3/RAF1/SOCS2/CISH/SLC2A2/MAPK8/FOS/ESR2/RELA/STAT1/SOCS1	2.45032541363012
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	26/1105	144/9376	1.53202614379085	PIK3R1/JAK2/AKT3/INHBA/IGF1R/IL6ST/RAF1/KAT6A/SMAD4/PCGF3/CTNNB1/BMPR2/FZD6/ZFHX3/JARID2/FGFR1/SMARCAD1/SMAD2/SKIL/RIF1/MYC/ID4/SETDB1/FGF2/ACVR1B/LEFTY2	2.35154930483227
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	16/1105	78/9376	1.74052674324168	CNOT4/DDX6/XRN1/PAN3/CNOT1/CNOT6L/MPHOSPH6/PARN/TOB2/TOB1/ZCCHC7/EXOSC10/MTREX/CNOT10/PABPC4/DIS3	2.40038577484651
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	25/1105	138/9376	1.53714997704768	FN1/PIK3R1/AKT3/PIP5K1A/TAB2/DOCK1/ARHGEF12/TBK1/MAPK8/FOS/VAV2/ITGA5/IKBKB/MAP2K4/MAP2K7/PXN/NFATC2/WIPF2/ARHGEF1/ARHGEF7/IL18/NFKBIA/RELA/TICAM1/BAIAP2	2.32345300417999
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	11/1105	47/9376	1.98586694907095	INSR/PIK3R1/SOCS2/SLC2A2/MAPK8/HK1/IRS2/CACNA1C/IKBKB/SOCS1/MTOR	2.47649500565399
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	39/1105	238/9376	1.39041028175976	VEGFA/FLT1/PDGFD/INSR/PIK3R1/AKT3/PLA2G5/IGF1R/PLA2G2A/PDGFRA/RAF1/PLA2G4A/RALGAPA1/ABL1/RAP1A/RAP1B/TBK1/PAK2/RASAL2/SHOC2/BCL2L1/MAPK8/RALGAPB/STK4/FGFR1/ETS2/IKBKB/GAB1/RAB5B/ABL2/RALGAPA2/RASA1/FGF2/GAB2/RELA/PLA2G6/PLCE1/GNG12/BRAP	2.22983082643299
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	22/1105	119/9376	1.5686680101905	PIK3R1/AKT3/PTGS2/JAG1/TAB2/CREB3L1/ATF4/MAPK8/FOS/ITCH/CFLAR/ADAM17/BAG4/IKBKB/MAP2K4/MAP2K7/RHBDF2/NFKBIA/RELA/RHBDF1/IL18R1/CREB3	2.28183855447594
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	19/1105	99/9376	1.62844736962384	PDGFD/PIK3R1/AKT3/EIF4EBP1/PDGFRA/RAF1/PIP5K1A/PLA2G4A/CHPT1/RHEB/MAPK8/FOS/CHKA/PDPK1/WASF3/RPS6KB1/PLPP1/DGKD/MTOR	2.29757924081875
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	10/1105	42/9376	2.02025425554837	TF/SAT1/PCBP1/MAP1LC3B/SLC3A2/MAP1LC3C/ACSL3/ACSL1/CP/ATG5	2.42207132818539
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	19/1105	101/9376	1.59620088705703	SERPINE1/FN1/FOXO1/VEGFA/PIK3R1/JAK2/AKT3/SMAD4/TGFB2/MAPK8/SMAD2/PIM1/BCL2/TGFBR1/TGFB1/RELA/STAT1/PLCE1/COL4A1	2.2018316614293
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	13/1105	62/9376	1.77912713472486	JAG1/NCSTN/HEYL/ITCH/CREBBP/SPEN/ADAM17/NOTCH2/EP300/ATXN1L/TLE1/MAML1/NCOR2	2.2496959400844
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	30/1105	178/9376	1.43006761909604	DKK1/APCDD1/PPARD/NKD1/SMAD4/TBL1XR1/CTNNB1/CAMK2D/TCF7L2/FZD6/CSNK2A2/MAPK8/BTRC/SIAH1/SENP2/NFATC4/SIRT1/CREBBP/PPP3CC/CSNK1E/MYC/EP300/TLE1/NFATC2/CUL1/ROR1/DAAM2/FOSL1/CCN4/CSNK1A1	2.11732638726923
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	22/1105	122/9376	1.53009420666123	IGFBP3/PIK3R1/JAK2/AKT3/RAF1/SOCS2/CREB3L1/ATF4/MAPK8/FOS/GNA11/CREBBP/IRS2/CACNA1C/EP300/GNAI1/MAP2K4/STAT1/CSH2/CREB3/SOCS1/MTOR	2.15405105392531
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	12/1105	56/9376	1.81822882999354	HSPA1A/BCL2L13/SAR1A/ARF1/RAB1A/HBS1L/BNIP3/IL18/NFKBIA/HSF1/SEC22B/RELA	2.24464984020201
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	25/1105	144/9376	1.47310206133736	FOXO1/FOXO3/AKT3/ADIPOR1/TAB2/PRKAG2/CTNNB1/LPIN2/LPIN1/TBK1/PRKAA1/TCF7L2/PPARA/MAPK8/SIRT1/FASN/TRA2A/IKBKB/MAP2K4/MAP2K7/NFKBIA/RELA/MLYCD/TICAM1/CAMKK2	2.09110555268113
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	22/1105	125/9376	1.49337194570136	PIK3R1/AKT3/PTEN/PPP2R5E/RAF1/S1PR2/CERS6/KNG1/MAPK8/PPP2R2D/CERS5/PDPK1/PPP2R3C/BCL2/PPP2R2A/SGPL1/GNAI1/S1PR3/SPTSSA/PPP2R5A/GAB2/RELA	2.02965808772041
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	55/1105	368/9376	1.26814873106433	GPX3/MT-ATP8/MT-ND4L/TPR/ATXN2/WIPI2/XBP1/MAP1LC3B/RANBP2/FUS/UBQLN1/NUP58/SQSTM1/NUP98/TBK1/PIK3C3/TUBA1C/MAP1LC3C/ATF4/OPTN/TARDBP/BCL2L1/DERL1/WIPI1/PINK1/TUBB4B/ATG2B/MCU/NUP50/PPP3CC/RAB1A/C9orf72/NRG2/BCL2/NXF1/NUP153/NUP93/ATF6/NUP155/TUBB6/EIF2AK3/TOMM40/PSMD14/NUP85/MT-ND6/DCTN5/BECN1/NUP88/ALS2/ATG13/UBQLN2/HDAC6/SMCR8/TUBB2A/MTOR	1.91810878098241
NA	NA	hsa04518	Integrin signaling	26/1105	154/9376	1.43254392666157	FN1/VEGFA/FLT1/PDGFD/PIK3R1/THBS1/AKT3/FBN1/LAMB1/IGF1R/TNC/PDGFRA/CTNNB1/FERMT2/LIMS2/LAMC3/FLNA/ITGA5/THBS2/PXN/TGFB1/ITGAV/COL6A3/ERBB2/MTOR/COL4A1	1.97817990914094
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	36/1105	227/9376	1.3456495305679	VEGFA/PIK3R1/HLA-G/AKT3/AKAP13/EIF4EBP1/PTGS2/PDGFRA/RAF1/IL6R/ARHGEF12/CTNNB1/CREB3L1/TBK1/RHEB/ATF4/NFATC4/MDM2/GNA11/PTGER2/PPP3CC/RPS6KB1/MYC/GNAI1/IKBKB/PXN/NFATC2/HLA-E/ARHGEF1/PTGER3/ITGAV/NFKBIA/RELA/CREB3/GNG12/MTOR	1.92685863239587
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/1105	99/9376	1.54273961332785	PIK3R1/AKT3/IGF1R/JAG1/RAF1/BRAF/MAPK8/FOS/MDM2/RPS6KB1/NOTCH2/BCL2/ESR2/ARAF/CARM1/ERBB2/HBEGF/MTOR	1.98423500363833
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	25/1105	148/9376	1.43328849211202	PIK3R1/AKT3/NCOA1/IGF1R/PTEN/JAG1/RAF1/BRAF/POLK/CTNNB1/TCF7L2/FZD6/FOS/HEYL/FGFR1/RPS6KB1/NOTCH2/MYC/ESR2/GADD45G/ARAF/FGF2/ERBB2/CSNK1A1/MTOR	1.94196762833167
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	30/1105	184/9376	1.38343497934291	PIK3R1/RAF1/NCK1/ABL1/PLXNB2/ARHGEF12/SEMA6D/PAK2/CAMK2D/BMPR2/SEMA4B/SSH2/NFATC4/CFL2/ABLIM2/ABLIM1/PDPK1/PPP3CC/SRGAP1/EPHB4/SLIT2/DPYSL2/GNAI1/NFATC2/MYL9/RASA1/PLXNA2/SEMA4C/PLXNA3/SRGAP2	1.91992118102992
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	26/1105	156/9376	1.41417797888386	PIK3R1/AKT3/PIAS1/YWHAQ/RAF1/BRAF/IFNAR1/CTNNB1/TBK1/PPARA/LDLR/MAVS/PPP2R2D/CFLAR/YWHAG/PPP2R2A/MYC/IKBKB/ARAF/CLDN11/NFKBIA/RELA/STAT1/PSME3/TICAM1/SCARB1	1.90665277536006
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	17/1105	93/9376	1.55103391232423	JAK2/IFNGR2/JAG1/IFNGR1/MAPK8/FOS/PPP3CC/NOTCH2/IKBKB/STAT6/NFATC2/MAML1/HLA-DRB5/NFKBIB/NFKBIA/RELA/STAT1	1.95192619935897
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	17/1105	93/9376	1.55103391232423	FN1/PIK3R1/AKT3/LAMB1/PTEN/PTGS2/POLK/BCL2L1/LAMC3/BCL2/MYC/GADD45G/IKBKB/ITGAV/NFKBIA/RELA/COL4A1	1.95192619935897
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/1105	73/9376	1.62727329077047	PDGFD/PIK3R1/AKT3/IGF1R/PTEN/PDGFRA/RAF1/BRAF/POLK/FGFR1/MDM2/GADD45G/ARAF/FGF2	1.96650240598206
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	25/1105	150/9376	1.41417797888386	PIK3R1/AKT3/RAF1/BRAF/POLK/SMAD4/CTNNB1/TGFB2/TCF7L2/FZD6/SMAD2/RPS6KB1/JUP/BCL2/MYC/GADD45G/TGFBR1/ARAF/TGFB1/GAB1/FGF2/ERBB2/CTNNA1/CSNK1A1/MTOR	1.8690188250611
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	34/1105	216/9376	1.33561253561254	APOB/APOA1/PIK3R1/JAK2/AKT3/XBP1/HSPA1A/TAB2/RAP1A/RAP1B/TBK1/CAMK2D/ATF4/LDLR/BCL2L1/MAPK8/NFE2L2/FOS/VAV2/PDPK1/PPP3CC/BCL2/IKBKB/MAP2K4/MAP2K7/ATF6/NFATC2/EIF2AK3/ARHGEF1/IL18/NFKBIA/ABCA1/RELA/TICAM1	1.82391703479683
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	26/1105	158/9376	1.39627699180938	RAD21/YWHAQ/PPP2R5E/SMAD4/ABL1/STAG2/MCM6/CCNH/TGFB2/SMAD2/MDM2/WAPL/YWHAG/CREBBP/SMC1A/TFDP2/MYC/PDS5A/GADD45G/EP300/CUL1/TGFB1/ANAPC4/PPP2R5A/CDK7/CDC14A	1.83610205183717
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	23/1105	137/9376	1.42450044588301	PIK3R1/AKT3/CTSB/CTSS/RAF1/TUBA1C/ATF4/BCL2L1/MAPK8/FOS/CFLAR/PDPK1/LMNA/BCL2/NOL3/GADD45G/IKBKB/EIF2AK3/MCL1/NFKBIA/CSF2RB/RELA/PARP4	1.82942124225409
NA	NA	hsa03272	Virion - Hepatitis viruses	10/1105	48/9376	1.76772247360483	LAMP2/PDCD6IP/TSG101/IST1/LDLR/CHMP4B/HSPG2/CLDN11/CHMP1A/SCARB1	1.94902931229816
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	36/1105	232/9376	1.31664846309877	FN1/PDGFD/C7/PIK3R1/AKT3/LPAR1/GSN/PDGFRA/RAF1/BRAF/PIP5K1A/DOCK1/ARHGEF12/PAK2/KNG1/SSH2/MYH11/FGFR1/CFL2/VAV2/PIP4K2A/ITGA5/ARHGAP35/ARAF/PXN/F2R/MYL9/NCKAP1/ARHGEF1/ARHGEF7/ITGAV/FGF2/IQGAP1/GNG12/BAIAP2/RGCC	1.78501156818385
Human Diseases	Cancer: specific types	hsa05214	Glioma	14/1105	76/9376	1.56303881876637	PIK3R1/AKT3/IGF1R/PTEN/PDGFRA/RAF1/BRAF/POLK/CAMK2D/MDM2/GADD45G/ARAF/CAMK1D/MTOR	1.80132230618807
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1105	37/9376	1.83460926990339	TPR/BRAF/POLK/CTNNB1/TCF7L2/MYC/GADD45G/CCDC6	1.85918088335048
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	25/1105	155/9376	1.36855933440374	THBS1/HLA-G/LAMP2/CTSS/ATP6V1E1/STX12/CANX/PIK3C3/TUBA1C/HGS/TUBB4B/ITGA5/THBS2/DYNC2H1/TUBB6/HLA-E/RAB5B/HLA-DRB5/ITGAV/DYNC1I2/FCGR2B/STX18/SEC22B/TUBB2A/SCARB1	1.6911106314251
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	25/1105	155/9376	1.36855933440374	CRH/USP8/BRAF/RAP1A/RAP1B/CYP11A1/CTNNB1/CREB3L1/CAMK2D/ATF4/TCF7L2/FZD6/LDLR/GNA11/KMT2A/RASD1/CACNA1C/GNAI1/WDR5/AHR/PDE8A/KCNK3/CREB3/SCARB1/RBBP5	1.6911106314251
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	27/1105	170/9376	1.34762842693639	LLGL2/AMOTL2/ARHGAP17/PRKAG2/RAP1A/TJP1/WHAMM/TUBA1C/PRKAA1/NEDD4L/GATA4/MAPK8/MYH11/NEDD4/PPP2R2D/PRKCI/F11R/PPP2R2A/RAP2C/RAB8B/STK11/MAP2K7/MYL9/CLDN11/SYNPO/EPB41L4B/ERBB2	1.67182965844252
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/1105	44/9376	1.73558206499383	RPN1/MGAT4B/MGAT1/MAGT1/STT3B/ST3GAL3/B4GALT3/MGAT4A/ALG12	1.78754865522674
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	23/1105	142/9376	1.37434197947868	PIK3R1/AKT3/IFNGR2/IFNGR1/TAB2/IFNAR1/SQSTM1/TGFB2/MAPK8/FOS/PPP3CC/TGFBR1/IKBKB/MAP2K7/NFATC2/TGFB1/NFKBIA/FCGR2B/GAB2/RELA/STAT1/FOSL1/SOCS1	1.64287884148586
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	23/1105	142/9376	1.37434197947868	VEGFA/PIK3R1/AKT3/DUSP1/CTNNB1/SQSTM1/BMPR2/PRKAA1/MAPK8/NFE2L2/FOS/SDC1/BCL2/IKBKB/MGST1/MAP2K4/MAP2K7/GPC1/CAV1/GSTM3/KEAP1/ITGAV/RELA	1.64287884148586
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	14/1105	78/9376	1.52296090033647	FN1/PIK3R1/ARHGEF26/DOCK1/CTNNB1/CLTCL1/CLTB/ITGA5/PXN/GAB1/CAV1/ARHGAP10/CD2AP/CTNNA1	1.69515539772869
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	25/1105	157/9376	1.35112545753235	THBS1/JAK2/PTGS2/MERTK/PPARD/DOCK1/VPS41/CAMK2D/NR1H2/NFATC4/SIRT1/ATP11B/SGK1/PTGER2/ADAM17/NFATC2/MFGE8/TGFB1/RAB5B/VPS39/ITGAV/ABCA1/PLA2G6/GULP1/ATP11A	1.62165327555424
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	4/1105	14/9376	2.42430510665805	ST3GAL1/ST3GAL3/B4GALT3/CHST2	1.94926326186929
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	27/1105	173/9376	1.32425914785656	PIK3R1/JAK2/AKT3/RAB11B/IFNGR2/RAF1/IFNGR1/KPNA6/IFNAR1/NUP98/TBK1/MAVS/PLG/HNRNPUL1/CREBBP/NXF1/CALCOCO2/EP300/KPNA1/IKBKB/HLA-DRB5/NFKBIB/IL18/NFKBIA/RELA/STAT1/TICAM1	1.57339709651104
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	12/1105	66/9376	1.54273961332785	IFNGR2/RORA/IFNGR1/TGFB2/SMAD2/STAT6/TGFB1/HLA-DRB5/IL18/RELA/IL18R1/STAT1	1.6172472263501
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	37/1105	250/9376	1.25579004524887	TPCN1/CTSB/LAMP2/CTSS/LITAF/AP5B1/ATP6V1E1/CTSA/GALNS/AP2A1/VPS41/CLTCL1/CLTB/MCOLN1/ABCA5/NPC1/ARL8A/SLC38A9/ARL8B/RPTOR/SLC36A4/AKT1S1/RRAGB/GM2A/GGA2/ARSG/PLEKHM1/AP3S1/OSTM1/DEPTOR/RRAGC/VPS39/AP5Z1/TTI1/ZFYVE26/OSBP/MTOR	1.49830827352348
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	7/1105	33/9376	1.79986288221582	VTI1A/BET1L/SNAP23/STX3/STX18/STX11/SEC22B	1.68235291910709
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/1105	15/9376	2.26268476621418	ST3GAL1/ST6GALNAC5/ST6GALNAC6/SLC33A1	1.78882235901598
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/1105	10/9376	2.54552036199095	MPST/PAPSS1/SQOR	1.78725047546466
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	32/1105	217/9376	1.2512542485977	VEGFA/PIK3R1/JAK2/AKT3/EIF4EBP1/UGT2B7/JAG1/RAF1/KPNA6/KPNA4/CREB3L1/ATF4/PPARA/FOS/UGT2B4/RPS6KB1/NOTCH2/BCL2/CACNA1C/MYC/ESR2/KPNA1/GNAI1/MGST1/GSTM3/FGF2/AHR/RELA/AR/CREB3/MTOR/VDR	1.36869606427146
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	16/1105	98/9376	1.3853172038046	PIK3R1/AKT3/ASAP1/GSN/RAF1/PIP5K1A/PLA2G4A/DOCK1/CFL2/VAV2/WASF3/RPS6KB1/PLPP1/FCGR2B/GAB2/PLA2G6	1.40149650981163
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	11/1105	63/9376	1.48151978740214	DLST/EHMT1/SETD2/NSD3/SETD7/EZH1/PRDM2/KMT2A/SETDB1/KMT2E/SETD1B	1.40161061719866
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	10/1105	56/9376	1.51519069166128	GANAB/RPN1/MGAT4B/MGAT1/MAGT1/STT3B/B4GALT3/MGAT4A/DHRSX/ALG12	1.41332431872413
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	13/1105	78/9376	1.41417797888386	JAK2/PTGS2/IFNGR2/IFNGR1/TAB2/TGFB2/FOS/TGFB1/HLA-DRB5/NFKBIB/NFKBIA/RELA/STAT1	1.34254020916978
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	12/1105	71/9376	1.43409597858645	PIK3R1/AKT3/PTEN/PDGFRA/RAF1/SLC1A5/SLC2A2/FGFR1/HK1/MYC/ERBB2/MTOR	1.34197527718905
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	31/1105	214/9376	1.2291453461327	PIK3R1/HLA-G/AKT3/RAF1/TAB2/TBK1/PAK2/CUL4A/BCL2L1/MAPK8/FOS/BTRC/NFATC4/DDB1/SAMHD1/CFL2/GNA11/PPP3CC/RPS6KB1/BCL2/GNAI1/IKBKB/MAP2K7/PXN/NFATC2/CUL1/HLA-E/NFKBIA/RELA/GNG12/MTOR	1.23939731520984
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	12/1105	72/9376	1.41417797888386	TBK1/AZI2/MAPK8/MAVS/ATG12/ATG5/IKBKB/DDX3X/NFKBIB/NFKBIA/RELA/OTUD5	1.28945493504077
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	8/1105	44/9376	1.54273961332785	RAB11B/ARHGDIA/CREB3L1/DYNC2H1/RAB5B/DCTN5/DYNC1I2/CREB3	1.31891941377148
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/1105	51/9376	1.49736491881821	PLA2G5/PLA2G2A/PLA2G4A/CHPT1/PAFAH1B1/PAFAH1B2/PLPP1/SELENOI/PLA2G6	1.30173800362122
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	6/1105	31/9376	1.64227120128448	GLUL/AGXT/ACSS2/MMUT/ACO1/SHMT1	1.30917411556259
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	7/1105	38/9376	1.56303881876637	INSR/PIK3R1/NEDD4L/SGK1/PDPK1/ATP1A1/SCNN1A	1.27113292695082
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	27/1105	187/9376	1.22511675176035	TXNIP/CTSB/CASP4/MAP1LC3B/TRPM7/TAB2/IFNAR1/ERBIN/TBK1/MAP1LC3C/BCL2L1/MAPK8/MAVS/MCU/BCL2/GABARAPL1/ATG12/ATG5/IKBKB/NOD1/NFKBIB/IL18/NFKBIA/DHX33/RELA/STAT1/TICAM1	1.13653354346317
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	4/1105	18/9376	1.88557063851182	MTR/MMUT/MTRR/ZNF143	1.37453469924859
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	64/1105	480/9376	1.13134238310709	GPX3/MT-ATP8/MT-ND4L/DKK1/PTGS2/ATXN2/WIPI2/ATXN3/XBP1/MAP1LC3B/RAF1/BRAF/FUS/CTNNB1/SQSTM1/TBK1/CAMK2D/PIK3C3/TUBA1C/MAP1LC3C/ATF4/IFT57/FZD6/OPTN/CSNK2A2/TARDBP/BCL2L1/MAPK8/DERL1/WIPI1/UBA1/PINK1/TUBB4B/PPIF/APP/ATG2B/MCU/PPP3CC/UBE2G1/UBC/CSNK1E/RAB1A/C9orf72/BCL2/CACNA1C/ATXN1L/ARAF/MAP2K7/ATF6/TUBB6/EIF2AK3/TOMM40/PSMD14/MT-ND6/DCTN5/BECN1/RELA/ALS2/ATG13/UBE2G2/SMCR8/CSNK1A1/TUBB2A/MTOR	1.0797317951116
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	11/1105	67/9376	1.39307084487067	RAF1/BRAF/RAP1A/RAP1B/CAMK2D/ATF4/CREBBP/PPP3CC/CACNA1C/EP300/ARAF	1.18016976783296
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	3/1105	12/9376	2.12126696832579	CD46/NPC1/FCGR2B	1.4205506253957
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	10/1105	60/9376	1.41417797888386	VEGFA/PIK3R1/AKT3/PTGS2/HSPB1/RAF1/PLA2G4A/PPP3CC/PXN/NFATC2	1.17634756150183
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	26/1105	181/9376	1.21884952876178	JAK2/AKT3/LAMP2/CTSS/IFNGR2/RAF1/IFNGR1/ARHGEF12/CAMK2D/PIK3C3/TGFB2/MAPK8/CREBBP/PPP3CC/BCL2/MALT1/BCL10/EP300/TGFB1/RAB5B/HLA-DRB5/IL18/FCGR2B/RELA/STAT1/VDR	1.08666781240232
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	12/1105	75/9376	1.35761085972851	PIK3R1/AKT3/ERCC1/TOP2B/BCL2L1/MDM2/PDPK1/BCL2/MGST1/GSTM3/SLC31A1/ERBB2	1.13648648381107
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	12/1105	75/9376	1.35761085972851	SERPINE1/IGFBP3/THBS1/SESN1/PTEN/RCHY1/BCL2L1/SIAH1/MDM2/BCL2/GADD45G/PPM1D	1.13648648381107
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/1105	32/9376	1.59095022624434	SUCLG2/ACSS2/MMUT/ALDH6A1/DBT/MLYCD	1.22390369047231
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	16/1105	105/9376	1.29296272355096	PIK3R1/AKT3/PTGS2/RAF1/ARHGEF12/MAPK8/NFATC4/MDM2/PPP3CC/MALT1/BCL10/IKBKB/NFATC2/NFKBIA/RELA/STAT1	1.10339621593386
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	29/1105	205/9376	1.20032667475996	PIK3R1/HLA-G/AKT3/POLK/CD44/TAB2/IFNAR1/TBK1/MAPK8/MAVS/USP7/NEDD4/MDM2/BCL2/MYC/GADD45G/IKBKB/MAP2K4/MAP2K7/HLA-E/PSMD14/SIN3A/NCOR2/HLA-DRB5/NFKBIB/NFKBIA/SAP30/RELA/STAT1	1.0599738051548
Human Diseases	Infectious disease: viral	hsa05162	Measles	20/1105	136/9376	1.24780409901517	PIK3R1/AKT3/HSPA1A/CD46/TAB2/IFNAR1/TBK1/RCHY1/CSNK2A2/BCL2L1/MAPK8/MAVS/FOS/BCL2/IKBKB/NFKBIB/NFKBIA/FCGR2B/RELA/STAT1	1.06397082965147
Organismal Systems	Digestive system	hsa04978	Mineral absorption	10/1105	61/9376	1.39099473332839	TF/HMOX2/TRPM7/SLC26A6/CYBRD1/SLC30A1/ATP1A1/SLC31A1/MT2A/VDR	1.1197785967388
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	14/1105	91/9376	1.30539505743126	PIK3R1/AKT3/RAF1/FOS/VAV2/PPP3CC/MALT1/BCL10/IKBKB/NFATC2/NFKBIB/NFKBIA/FCGR2B/RELA	1.06998949285843
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1105	26/9376	1.63174382178907	APOB/APOA1/SLC19A3/SCARB1/BTD	1.17898868941571
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	19/1105	130/9376	1.24012530455969	VEGFA/PIK3R1/AKT3/RAF1/CREB3L1/ATF4/MAPK8/FOS/SMAD2/TGFBR1/GNAI1/MAP2K4/MAP2K7/TGFB1/NFKBIA/RELA/CREB3/GNG12/COL4A1	1.00767486791533
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	11/1105	70/9376	1.33336780866193	HLA-G/EIF4G1/EIF4G2/ABL1/DMD/SNTB2/HLA-E/ABL2/CAV1/HLA-DRB5/CD55	1.02324333145119
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	4/1105	20/9376	1.69701357466063	CYP51A1/MSMO1/SOAT1/LSS	1.14050946637278
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	11/1105	71/9376	1.31458798037091	ATP6V1E1/TJP1/MAPK8/F11R/ADAM17/IKBKB/NOD1/MAP2K4/NFKBIA/RELA/HBEGF	0.972525231708692
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	20/1105	140/9376	1.21215255332902	SERPINE1/AKT3/JAG1/MAP1LC3B/RAF1/SMAD4/PRKAG2/PIK3C3/PRKAA1/MAP1LC3C/SMAD2/MEF2D/NRF1/RPS6KB1/HDAC5/TGFBR1/GNAI1/BECN1/GNG12/MTOR	0.924396059551486
NA	NA	hsa04517	IgSF CAM signaling	40/1105	299/9376	1.13512613689674	FOXO1/PIK3R1/AKT3/NCK1/PPFIA1/ABL1/RAP1A/RAP1B/TJP1/NECTIN2/CTNNB1/SSX2IP/PAK2/TUBA1C/MAPK8/NFASC/MYH11/FGFR1/TUBB4B/PRKCI/APP/VAV2/PDPK1/F11R/ITGA5/CLMP/SRGAP1/SLIT2/PXN/TUBB6/MYL9/RASA1/PLXNA2/PLXNA3/PVR/CD2AP/SRGAP2/IQGAP1/BAIAP2/TUBB2A	0.867943698061568
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	28/1105	205/9376	1.15893609976824	PIK3R1/HLA-G/GSN/UBE3A/IL6ST/YWHAQ/SND1/CREB3L1/CHD4/ATF4/USP7/GTF2H1/DDB1/MDM2/YWHAG/CREBBP/HDAC5/EP300/PXN/GTF2E2/GTF2A1/HLA-E/DDX3X/NFKBIA/RELA/SRF/CREB3/HDAC6	0.840966898939781
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	10/1105	65/9376	1.30539505743126	CYP11A1/CREB3L1/ATF4/LDLR/GNA11/CACNA1C/PDE8A/KCNK3/CREB3/SCARB1	0.903042699247846
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	13/1105	88/9376	1.25347593582888	SERPINE1/C7/CFH/SERPINC1/CD59/SERPINE2/C1S/CD46/KNG1/PLG/CLU/F2R/CD55	0.873181919928299
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	11/1105	73/9376	1.27857187131966	FOXO3/PIK3R1/AKT3/RAF1/BRAF/POLK/STK4/PDPK1/GADD45G/ARAF/ERBB2	0.873323100551845
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	7/1105	43/9376	1.38129011890982	APOB/APOA1/PLA2G5/PLA2G2A/PLPP1/ABCA1/SCARB1	0.915939761471446
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	13/1105	89/9376	1.2393919365499	FN1/THBS1/LAMB1/TNC/CD44/LAMC3/SDC1/ITGA5/THBS2/HSPG2/ITGAV/COL6A3/COL4A1	0.829381922891658
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	13/1105	89/9376	1.2393919365499	PDGFD/LPAR1/MAP3K2/PDGFRA/CSNK1D/RAF1/TJP1/TUBA1C/TUBB4B/GNA11/GNAI1/TUBB6/TUBB2A	0.829381922891658
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	20/1105	144/9376	1.17848164906988	PIK3R1/AKT3/ATXN2/WIPI2/ATXN3/XBP1/RORA/AFG3L2/PIK3C3/MAPK8/PUM1/WIPI1/PPIF/ATG2B/MCU/ATXN1L/PSMD14/BECN1/ATG13/MTOR	0.788886791925398
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	31/1105	233/9376	1.12891460975278	FN1/SYNE2/THBS1/NID1/FBN1/SYNE3/FBN2/PDLIM3/TNNT2/MYH11/ACTG2/PLEC/DMD/TMEM43/SDC1/LMNA/JUP/ITGA5/SNTB2/THBS2/TPM2/ATP1A1/HSPG2/MYL9/DAAM2/PDLIM5/ITGAV/COL6A3/TPM4/BGN/COL4A1	0.728322129227603
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	11/1105	75/9376	1.2444766214178	GLUL/ALDOB/PGK1/MAT2B/MTR/ACO1/ASL/CTH/BCAT2/SHMT1/ALDH18A1	0.77694613653528
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	15/1105	107/9376	1.18949549625745	FOXO1/AKT3/PPP4R3A/PRKAG2/CREB3L1/CAMK2D/PRKAA1/ATF4/SLC2A2/PPARA/SIRT1/CREBBP/PPP3CC/EP300/CREB3	0.720546656184927
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	30/1105	227/9376	1.12137460880659	MT-ATP8/VEGFA/MT-ND4L/FOXO3/PIK3R1/AKT3/PTEN/PTPN1/RAF1/BRAF/ABL1/SLC26A6/MAPK8/NFE2L2/FOS/PPIF/PDPK1/PRKD1/IKBKB/MGST1/ARAF/MAP2K4/MAP2K7/ABL2/GSTM3/MT-ND6/KEAP1/NFKBIA/AHR/RELA	0.676615160878101
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	10/1105	69/9376	1.22971998163814	PIK3R1/AKT3/RAF1/PLA2G4A/MAPK8/VAV2/PDPK1/MAP2K4/MAP2K7/GAB2	0.700013197767796
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	15/1105	109/9376	1.16766989082154	PIK3R1/AKT3/TAB2/IFNAR1/TBK1/MAPK8/FOS/TOLLIP/IKBKB/MAP2K4/MAP2K7/NFKBIA/RELA/STAT1/TICAM1	0.643556255062099
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	8/1105	54/9376	1.25704709234121	ERCC1/POLK/FANCC/RPA1/WDR48/RPA2/TOP3A/POLI	0.692377255624762
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	20/1105	149/9376	1.13893528500714	PDGFD/INSR/PIK3R1/AKT3/LPAR1/PDGFRA/RAF1/PIP5K1A/PLA2G4A/CYTH1/RHEB/CYTH3/AGPAT4/ARF1/PLPP1/DGKD/GAB1/F2R/GAB2/MTOR	0.624831904624445
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	22/1105	166/9376	1.1245270675462	INSR/AKT3/KCNMA1/RAF1/CREB3L1/KNG1/ATF4/GATA4/NFATC4/PPIF/MEF2D/GNA11/PPP3CC/ADRA2C/IRS2/CACNA1C/GNAI1/ATP1A1/NFATC2/MYL9/SRF/CREB3	0.591664833180749
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1105	55/9376	1.23419169066228	CERS6/CERS5/B4GALT5/SGPL1/GM2A/PLPP1/KDSR/SMPD4	0.636662601327927
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	49/1105	388/9376	1.07156784997901	MT-ATP8/MT-ND4L/INSR/PIK3R1/AKT3/DKK1/PTGS2/WIPI2/SLC39A1/XBP1/RAF1/BRAF/CTNNB1/PIK3C3/TUBA1C/NCSTN/ATF4/FZD6/CSNK2A2/MAPK8/RTN3/WIPI1/TUBB4B/PPIF/APP/ATG2B/MCU/PPP3CC/SLC39A9/CSNK1E/ADAM17/IRS2/CACNA1C/IKBKB/ARAF/MAP2K7/ATF6/TUBB6/EIF2AK3/PSMD14/MT-ND6/SLC39A11/BECN1/RELA/ATG13/RTN4/CSNK1A1/TUBB2A/MTOR	0.526247527261211
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1105	17/9376	1.49736491881821	MTR/PAPSS1/CTH	0.750192388222837
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	3/1105	17/9376	1.49736491881821	LAMP2/MYH11/PCDH7	0.750192388222837
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	7/1105	48/9376	1.23740573152338	ACAA2/AACS/MMUT/ALDH6A1/MCCC2/DBT/BCAT2	0.602705724470982
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	5/1105	33/9376	1.28561634443987	DLST/AGXT/ACO1/DBT/BCAT2	0.600737328230546
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	6/1105	41/9376	1.24171724975168	RAD50/RPA1/UIMC1/RPA2/TOP3A/POLD3	0.566930965028526
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	14/1105	105/9376	1.13134238310709	CCL21/PTGS2/TAB2/CSNK2A2/BCL2L1/CFLAR/BCL2/MALT1/BCL10/GADD45G/IKBKB/NFKBIA/RELA/TICAM1	0.494679619152601
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	3/1105	18/9376	1.41417797888386	ACSL3/ACSL1/FASN	0.64286458796468
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	27/1105	212/9376	1.08064543669427	VEGFA/FLT1/PDGFD/INSR/PIK3R1/THBS1/AKT3/LPAR1/IGF1R/PDGFRA/RAF1/BRAF/CTNND1/RAP1A/RAP1B/CTNNB1/CNR1/FGFR1/RAPGEF1/PRKCI/VAV2/PRKD1/GNAI1/F2R/FGF2/PLCE1/SIPA1L1	0.434103167711893
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	4/1105	26/9376	1.30539505743126	PLA2G5/PLA2G2A/PLA2G4A/PLA2G6	0.569941970299361
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	13/1105	98/9376	1.12557022809124	CYP11A1/CREB3L1/CAMK2D/ATF4/LDLR/GNA11/PRKD1/CACNA1C/ATP1A1/CAMK1D/KCNK3/CREB3/SCARB1	0.456730804304715
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	13/1105	99/9376	1.11420083184789	PRKAG2/PRKAA1/TNNT2/TGFB2/DMD/LMNA/ITGA5/CACNA1C/SNTB2/TPM2/TGFB1/ITGAV/TPM4	0.417513817736239
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	11/1105	83/9376	1.1245270675462	PCBP1/POLR3D/TBK1/MAVS/SAMHD1/IKBKB/NFKBIB/IL18/NFKBIA/ZCCHC3/RELA	0.416497698155096
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	5/1105	35/9376	1.21215255332902	ALDOB/ENOSF1/PMM2/HK1/HSD17B14	0.459592958268657
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	17/1105	133/9376	1.08455754771544	AKT3/PPP2R5E/CREB3L1/CAMK2D/ATF4/MAPK8/FOS/PPP2R2D/PPP3CC/PPP2R3C/GSK3A/PPP2R2A/CACNA1C/GNAI1/PPP2R5A/CREB3/GNG12	0.358971103513315
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	17/1105	134/9376	1.07646383467279	PLA2G5/CALD1/KCNMA1/PLA2G2A/RAF1/BRAF/PLA2G4A/ARHGEF12/MYH11/ACTG2/GNA11/CACNA1C/RAMP1/ARAF/MYL9/ARHGEF1/PLA2G6	0.325846648228735
Organismal Systems	Nervous system	hsa04730	Long-term depression	8/1105	60/9376	1.13134238310709	IGF1R/CRH/RAF1/BRAF/PLA2G4A/GNA11/GNAI1/ARAF	0.373038403698395
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	7/1105	52/9376	1.14222067525235	INSR/IGF1R/PTGS2/PLA2G4A/CYP11A1/LDLR/SCARB1	0.375881578937501
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	12/1105	93/9376	1.09484746752299	MAP3K2/RAF1/PLA2G4A/CAMK2D/ATF4/MAPK8/GNA11/CACNA1C/MAP3K3/MAP2K4/MAP2K7/HBEGF	0.335977972789516
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	5/1105	36/9376	1.17848164906988	MCM6/RPA1/RPA2/POLE3/POLD3	0.392156257238769
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1105	12/9376	1.41417797888386	VKORC1/VKORC1L1	0.524728546857223
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1105	45/9376	1.13134238310709	ABCA8/ABCA5/ABCD3/ABCA1/ABCA9/ABCC9	0.322800962456832
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	5/1105	37/9376	1.14663079368962	UGP2/PMM2/PGM3/HK1/GFPT1	0.326635682550953
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	3/1105	21/9376	1.21215255332902	CHSY1/XYLT1/CHST11	0.355732693949027
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	5/1105	38/9376	1.11645629911884	UGP2/PMM2/PGM3/HK1/GFPT1	0.262915151543419
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	5/1105	38/9376	1.11645629911884	NNMT/NT5C2/SIRT1/NADK/SIRT7	0.262915151543419
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	4/1105	30/9376	1.13134238310709	PLA2G5/PLA2G2A/PLA2G4A/PLA2G6	0.263354290265423
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1105	30/9376	1.13134238310709	MTR/IKBKB/RELA/SHMT1	0.263354290265423
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	19/1105	157/9376	1.02685534772459	INSR/PIK3R1/AKT3/XBP1/ADIPOR1/IL6R/PRKAG2/PRKAA1/ATF4/PPARA/MAPK8/FOS/ITCH/GSK3A/IRS2/IKBKB/TGFB1/EIF2AK3/RELA	0.124029920558273
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	5/1105	39/9376	1.08782921452605	AHCYL1/MAT2B/MTR/CTH/SHMT1	0.20088864511608
Genetic Information Processing	Transcription	hsa03040	Spliceosome	29/1105	243/9376	1.01262126883042	PCBP1/SNRNP70/CDC5L/SRSF4/U2SURP/SNRNP200/SLU7/WBP11/SF3B1/HSPA1A/RBMX/FUS/RBM25/PRPF8/U2AF2/CASC3/SF3B3/CTNNBL1/TRA2A/CRNKL1/HNRNPM/ACIN1/DDX23/RBMXL1/HNRNPU/SNIP1/DHX8/PRPF3/DHX38	0.0728596686764668
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1105	65/9376	1.04431604594501	LPIN2/LPIN1/AGPAT4/GPAT4/ABHD16A/PLPP1/DGKD/GPAT3	0.131041026291584
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	24/1105	201/9376	1.01314243263321	IGFBP3/FOXO1/ZBTB16/FLT1/IGF1R/AFF1/POLK/SS18/CCNT2/RUNX2/FUS/TAF15/BCL2L1/MDM2/KMT2A/JUP/MYC/SUPT3H/GADD45G/ASPSCR1/SIN3A/RELA/KDM6A/ELK4	0.0688427988571994
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	3/1105	23/9376	1.10674798347433	RPA1/RPA2/POLD3	0.187342321395965
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	3/1105	23/9376	1.10674798347433	CTSA/LNPEP/ENPEP	0.187342321395965
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	10/1105	83/9376	1.02229733413291	BAAT/AGXT/ACSL3/PEX14/ACSL1/ABCD3/PEX13/MLYCD/SLC25A17/DECR2	0.0745764637708756
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	6/1105	49/9376	1.03898790285345	GALNT15/ST3GAL3/B4GALT3/POFUT2/GALNT2/FUT11	0.100010291631657
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1105	49/9376	1.03898790285345	CREB3L1/ATF4/GNAI1/GPSM1/RELA/CREB3	0.100010291631657
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1105	32/9376	1.0606334841629	BCL2L1/MAPK8/BCL2/BECN1	0.125576642054586
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	6/1105	50/9376	1.01820814479638	THBS1/TGFB2/SDC1/THBS2/TGFB1/IL18	0.0471835661341737
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	9/1105	76/9376	1.00481066920695	APOA2/APOC3/APOA1/PPARD/PPARA/ACSL3/PDPK1/ACSL1/UBC	0.0153907074634124
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7/1105	59/9376	1.00670296801902	INSR/PIK3R1/AKT3/PTGS2/IRS2/GNAI1/PTGER3	0.0188774301590735
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	18/1105	154/9376	0.991761179996474	AKT3/PPP2R5E/CREB3L1/CAMK2D/TNNT2/ATF4/PPP2R2D/PPP2R3C/BCL2/PPP2R2A/CACNA1C/SCN7A/GNAI1/TPM2/ATP1A1/PPP2R5A/TPM4/CREB3	-0.03767910540738
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	11/1105	94/9376	0.992933474535477	PTGS2/TAB2/TBK1/MAPK8/FOS/USP25/IKBKB/NFKBIA/RELA/FOSL1/MAPK6	-0.0251673123905036
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	10/1105	86/9376	0.986635799221299	CTNNB1/TCF7L2/DMD/LMNA/JUP/ITGA5/CACNA1C/SNTB2/ITGAV/CTNNA1	-0.0455063630304125
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	8/1105	69/9376	0.983775985310512	CREB3L1/CAMK2D/ATF4/FOS/SIRT1/PPP3CC/CACNA1C/CREB3	-0.0494385569876542
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1105	16/9376	1.0606334841629	ST3GAL1/A4GALT	0.0887201685958843
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	9/1105	78/9376	0.979046293073442	C1S/MAPK8/FOS/CFL2/ITGA5/GNAI1/NOD1/RELA/TICAM1	-0.0679205450658475
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	16/1105	139/9376	0.976698460236336	PIK3R1/AKT3/NCOA1/FKBP5/RAF1/HSPA1A/CREB3L1/KRT18/ATF4/FOS/BCL2/ESR2/GNAI1/CREB3/HBEGF/NCOA2	-0.101161279852265
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	26/1105	226/9376	0.976158250910984	PIK3R1/AKT3/CRH/RAF1/BRAF/RAP1A/RAP1B/CREB3L1/CAMK2D/PPARA/MAPK8/FOS/VAV2/CREBBP/PTGER2/CACNA1C/EP300/GNAI1/ATP1A1/F2R/MYL9/PTGER3/NFKBIA/RELA/PLCE1/CREB3	-0.132607947305231
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	13/1105	115/9376	0.959181585677749	PIK3R1/JAK2/AKT3/CREB3L1/CAMK2D/ATF4/FOS/GNA11/BCL2/CACNA1C/GNAI1/CREB3/GNG12	-0.160977016665572
Cellular Processes	Cell motility	hsa04814	Motor proteins	22/1105	194/9376	0.962224191817885	HOOK3/MYO9A/TUBA1C/TNNT2/MYH11/ACTG2/TUBB4B/TPM2/DYNC2H1/TUBB6/MYL9/TUBE1/DCTN5/KIF2A/DYNC1I2/TPM4/MYO9B/STARD9/KIF3B/KIF21A/MYO1E/TUBB2A	-0.194327271112698
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	2/1105	17/9376	0.998243279212137	BAAT/GGT5	-0.00264972158956995
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	2/1105	17/9376	0.998243279212137	GLUL/CA8	-0.00264972158956995
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	13/1105	116/9376	0.950912778904665	PIK3R1/CTNND1/RAP1A/RAP1B/CTNNB1/VAV2/F11R/ARHGAP35/GNAI1/PXN/MYL9/CLDN11/CTNNA1	-0.194437359563013
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	6/1105	54/9376	0.942785319255908	AHCYL1/MPST/MAT2B/MTR/CTH/BCAT2	-0.154112397359691
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/1105	36/9376	0.942785319255908	UGP2/UGT2B7/FGGY/UGT2B4	-0.125710935419076
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	4/1105	36/9376	0.942785319255908	UGP2/GBE1/HK1/TREH	-0.125710935419076
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	4/1105	36/9376	0.942785319255908	GALNT15/ST3GAL1/B4GALT5/GALNT2	-0.125710935419076
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	3/1105	27/9376	0.942785319255908	BAAT/ELOVL5/HACD2	-0.108816448604994
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	9/1105	82/9376	0.931287937313762	HLA-G/CTSB/CTSS/CANX/HSPA1A/HLA-E/HLA-DRB5/IFI30/PSME3	-0.228415906865412
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	5/1105	46/9376	0.922289986228605	UGT2B7/HMOX2/UGT2B4/CP/COX10	-0.193109147532628
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	4/1105	37/9376	0.917304634951694	GLUL/AGXT/GFPT1/ASL	-0.184212717715558
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	17/1105	154/9376	0.936663336663337	PTGS2/RAF1/PLA2G4A/PRKAG2/CAMK2D/PRKAA1/FOS/NFATC4/RCAN1/PPP3CC/CACNA1C/GNAI1/EEF2/NFATC2/MYL9/CAMK1D/CAMKK2	-0.28966148222592
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	3/1105	28/9376	0.909114414996768	ACAA2/ELOVL5/HACD2	-0.176036383409821
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1105	28/9376	0.909114414996768	A4GALT/ST3GAL3/B4GALT3	-0.176036383409821
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	15/1105	138/9376	0.922289986228605	IGF1R/YWHAQ/PPP2R5E/CAMK2D/BTRC/YWHAG/PPP3CC/SLK/CPEB2/SMC1A/CPEB3/CUL1/ANAPC4/PPP2R5A/AR	-0.336136223898583
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	8/1105	75/9376	0.905073906485671	GPX3/ALB/TTR/CANX/CREB3L1/ATF4/ATP1A1/CREB3	-0.301674905292091
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	2/1105	19/9376	0.89316503929507	DLST/DBT	-0.170376482245418
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	6/1105	57/9376	0.89316503929507	ACAA2/ELOVL5/ACSL3/ACSL1/FASN/HACD2	-0.295701776304612
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	11/1105	103/9376	0.906172297148882	SLC38A2/SLC1A5/SLC3A2/COL12A1/SLC36A4/COL18A1/ATP1A1/COL8A1/COL6A3/SLC7A8/COL4A1	-0.349967192101202
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	11/1105	103/9376	0.906172297148882	FN1/PIK3R1/LAMB1/HSPB1/TGFB2/LAMC3/GNA11/TGFB1/RAB5B/RELA/COL4A1	-0.349967192101202
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	5/1105	48/9376	0.883861236802413	PIK3R1/AKT3/SLC2A2/HK1/ATP1A1	-0.294843334080468
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	9/1105	86/9376	0.887972219299169	KCNMA1/CREB3L1/CAMK2D/ATF4/SLC2A2/GNA11/CACNA1C/ATP1A1/CREB3	-0.381465150253364
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	2/1105	20/9376	0.848506787330317	UGP2/CYB5R3	-0.247885334550511
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	3/1105	30/9376	0.848506787330317	DLST/SUCLG2/ACO1	-0.30375866920371
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	11/1105	105/9376	0.888911872441284	TNNT2/TGFB2/DMD/LMNA/ITGA5/CACNA1C/SNTB2/TPM2/TGFB1/ITGAV/TPM4	-0.418395276019284
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	6/1105	59/9376	0.862888258302017	GPX3/PRDX6/PGD/GGT5/MGST1/GSTM3	-0.386144961537658
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	5/1105	50/9376	0.848506787330317	SAT1/P4HA1/CKB/AOC1/ALDH18A1	-0.392571022408583
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	29/1105	268/9376	0.91816032957385	MT-ATP8/MT-ND4L/DUSP1/SLC39A1/XBP1/CAMK2D/TUBA1C/ATF4/BCL2L1/MAPK8/NFE2L2/UBA1/PINK1/TUBB4B/PPIF/MCU/UBE2G1/SLC39A9/UBC/GNAI1/ATF6/TUBB6/EIF2AK3/PSMD14/MT-ND6/KEAP1/SLC39A11/UBE2G2/TUBB2A	-0.496829671360821
Organismal Systems	Endocrine system	hsa04924	Renin secretion	7/1105	69/9376	0.860803987146698	KCNMA1/CTSB/PTGER2/PPP3CC/CACNA1C/PDE1C/GNAI1	-0.424164434365379
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	3/1105	31/9376	0.821135600642242	ALDOB/PGD/DERA	-0.364588418983318
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/1105	31/9376	0.821135600642242	UGT2B7/UGT2B4/HSD17B14	-0.364588418983318
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	3/1105	31/9376	0.821135600642242	SRP54/BAG6/SGTA	-0.364588418983318
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	12/1105	116/9376	0.877765642065845	ALDOB/DLST/PGD/PGK1/SUCLG2/AGXT/HK1/ACSS2/MMUT/ALDH6A1/ACO1/SHMT1	-0.484177455440763
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	25/1105	235/9376	0.902666795032252	MT-ATP8/MT-ND4L/SMARCD2/FRS2/PRKAG2/CREB3L1/KDM3B/RHEB/PRKAA1/CNR1/SMARCC1/FGFR1/ACSL3/NDUFAF2/ACSL1/RPS6KB1/RPTOR/AKT1S1/NDUFAF7/ARID1B/MT-ND6/COX10/KDM1A/CREB3/MTOR	-0.552313765510123
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	33/1105	308/9376	0.909114414996768	GPX3/MT-ATP8/MT-ND4L/WIPI2/AP2A1/CREB3L1/CLTCL1/CLTB/PIK3C3/TUBA1C/IFT57/RCOR1/MAPK8/WIPI1/TUBB4B/PPIF/ATG2B/NRF1/CREBBP/EP300/MAP2K7/TUBB6/PSMD14/SIN3A/MT-ND6/DCTN5/BECN1/SLC1A3/ATG13/TAF4/CREB3/TUBB2A/MTOR	-0.592792057734286
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	11/1105	110/9376	0.848506787330317	PIK3R1/AKT3/IGF1R/RAF1/BRAF/MAPK8/CPEB2/GNAI1/ARAF/CPEB3/ANAPC4	-0.58415908732988
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	20/1105	193/9376	0.879281644901883	FOXO3/PIK3R1/JAK2/AKT3/CCL21/RAF1/BRAF/RAP1A/RAP1B/VAV2/GSK3A/GNAI1/IKBKB/PXN/NFKBIB/NFKBIA/GRK5/RELA/STAT1/GNG12	-0.619366109998739
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	5/1105	53/9376	0.800478101255016	AP2A1/CLTCL1/CLTB/ATP1A1/VDR	-0.532400468036856
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	10/1105	101/9376	0.840105730030017	RAF1/CTNNB1/CREB3L1/CAMK2D/TCF7L2/FZD6/CREBBP/EP300/GNAI1/CREB3	-0.590506109172152
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	6/1105	63/9376	0.808101702219349	PLA2G5/PTGS2/PLA2G2A/PLA2G4A/GGT5/PLA2G6	-0.558578689035436
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	6/1105	63/9376	0.808101702219349	POLK/CTNNB1/TCF7L2/FZD6/GADD45G/BMP2	-0.558578689035436
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	2/1105	23/9376	0.737831988982884	GLUL/ASL	-0.46010390249219
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	2/1105	23/9376	0.737831988982884	ST3GAL3/B4GALT3	-0.46010390249219
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1105	23/9376	0.737831988982884	RCE1/HMGCR	-0.46010390249219
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	4/1105	44/9376	0.771369806663924	POLG/PARP4/POLE3/POLD3	-0.55559755204956
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	3/1105	34/9376	0.748682459409103	POLR3D/CRCP/POLR2M	-0.536574580709169
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	17/1105	168/9376	0.858608058608059	GLUL/JAK2/IFNGR2/IFNGR1/PLA2G4A/TRPM7/IFNAR1/SQSTM1/CAMK2D/MAPK8/CFLAR/BCL2/STAT6/CHMP4B/CHMP1A/STAT1/TICAM1	-0.675903055893898
NA	NA	hsa04519	Cadherin signaling	43/1105	404/9376	0.903113659782268	TEAD1/IGF1R/PDGFRA/AMOTL2/YWHAQ/RAF1/TAOK3/CTNND1/TJP1/LATS2/CTNNB1/ERBIN/KRT18/LIMA1/SHOC2/NCSTN/TCF7L2/FZD6/MAPK8/FGFR1/ATN1/CDH13/YWHAG/VAV2/CREBBP/YAP1/JUP/TEAD3/EP300/ARHGAP35/IKBKB/SAV1/NCKAP1/DAAM2/NFKBIA/WTIP/RELA/ERBB2/MYO1E/AJUBA/CTNNA1/CSNK1A1/PCDH7	-0.727606161488698
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	6/1105	65/9376	0.783237034458754	PIK3R1/AKT3/RAF1/GNA11/CACNA1C/ESR2	-0.640960646664678
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	1/1105	13/9376	0.652697528715628	RAD50	-0.457994017242877
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1105	66/9376	0.771369806663924	UGT2B7/CYP3A5/HSD17B11/CYP11A1/UGT2B4/STS	-0.681268764897214
Organismal Systems	Immune system	hsa04611	Platelet activation	12/1105	126/9376	0.808101702219349	PIK3R1/AKT3/PLA2G4A/ARHGEF12/RAP1A/RAP1B/PRKCI/ARHGAP35/GNAI1/SNAP23/F2R/ARHGEF1	-0.792635091274429
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	3/1105	37/9376	0.68797847621377	APOA1/KNG1/IL18	-0.695061117982068
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	7/1105	79/9376	0.751841457128129	ATP6V1E1/AP2A1/CLTCL1/CLTB/STXBP1/STX3/SLC1A3	-0.809578800662088
Organismal Systems	Digestive system	hsa04976	Bile secretion	8/1105	90/9376	0.754228255404726	UGT2B7/BAAT/SLC4A2/LDLR/UGT2B4/ATP1A1/HMGCR/SCARB1	-0.856301360739102
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1105	15/9376	0.565671191553544	AK2	-0.615305660211002
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	6/1105	70/9376	0.727291531997414	PTGS2/UGT2B7/CYP3A5/UGT2B4/MGST1/GSTM3	-0.837054790724869
Human Diseases	Immune disease	hsa05330	Allograft rejection	3/1105	39/9376	0.652697528715628	HLA-G/HLA-E/HLA-DRB5	-0.794372615971564
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	12/1105	133/9376	0.765570033681489	PIK3R1/HLA-G/IFNGR2/RAF1/IFNGR1/BRAF/IFNAR1/VAV2/PPP3CC/ARAF/NFATC2/HLA-E	-0.995222614415729
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	3/1105	41/9376	0.620858624875841	AGXT/CTH/SHMT1	-0.889249674577207
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	32/1105	323/9376	0.840625919336537	VEGFA/PIK3R1/THBS1/TIMP3/PTEN/PTGS2/TNC/FOXP1/PDGFRA/RAF1/CD44/ABL1/BMPR2/TGFB2/PIM1/SIRT1/MDM2/CREBBP/RPTOR/HDAC5/ITGA5/NOTCH2/IRS2/BCL2/MYC/EP300/IKBKB/MCL1/ERBB2/ZFPM2/SOCS1/MTOR	-1.06539452433743
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	1/1105	17/9376	0.499121639606069	BAAT	-0.755491831401976
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1105	30/9376	0.565671191553544	PIGN/PGAP1	-0.870871628672844
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	10/1105	115/9376	0.737831988982884	DUSP1/PTGS2/RAF1/BRAF/PLA2G4A/APP/CACNA1C/GNAI1/ARAF/GNG12	-1.03392120883237
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	8/1105	95/9376	0.714532031436056	VEGFA/FLT1/ATP6V1E1/TGFB2/FOS/TGFB1/HLA-DRB5/IL18	-1.02213807837718
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	2/1105	31/9376	0.547423733761495	ALDH6A1/MLYCD	-0.922509263831955
NA	NA	hsa04981	Folate transport and metabolism	2/1105	31/9376	0.547423733761495	MTR/SHMT1	-0.922509263831955
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	19/1105	205/9376	0.786420924842733	PDK4/MT-ATP8/MT-ND4L/INSR/PIK3R1/AKT3/PTEN/CAMK2D/TGFB2/PPARA/MAPK8/SMAD2/PPIF/TGFBR1/TGFB1/GFPT1/MT-ND6/RELA/MTOR	-1.1300952569954
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	3/1105	43/9376	0.591981479532779	ACAA2/ACSL3/ACSL1	-0.980147052803827
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	24/1105	254/9376	0.801738696690063	VEGFA/FLT1/PDGFD/TPCN1/PDGFRA/ORAI3/CAMK2D/MCOLN1/FGFR1/NFATC4/PPIF/GNA11/MCU/PPP3CC/CACNA1C/PDE1C/NFATC2/F2R/PTGER3/CAMK1D/FGF2/ERBB2/ITPKC/PLCE1	-1.1708399916159
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	2/1105	32/9376	0.530316742081448	UGP2/HK1	-0.972750406363137
Human Diseases	Immune disease	hsa05310	Asthma	2/1105	32/9376	0.530316742081448	PRG2/HLA-DRB5	-0.972750406363137
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	3/1105	44/9376	0.578527354997943	HLA-G/HLA-E/HLA-DRB5	-1.02422679350482
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1105	19/9376	0.446582519647535	GALNS	-0.882569927422879
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	7/1105	89/9376	0.667364888911485	GLUL/SLC38A2/TRAK2/CACNA1C/GABARAPL1/GNAI1/GNG12	-1.15242623470054
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	3/1105	45/9376	0.565671191553544	HLA-G/HLA-E/HLA-DRB5	-1.06745251664067
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	13/1105	154/9376	0.716271963330787	UGP2/UGT2B7/MAT2B/PMM2/VKORC1/UGT2B4/NADK/DHRS3/AK2/VKORC1L1/COX10/BCAT2/SHMT1	-1.29759098950008
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	1/1105	21/9376	0.404050851109675	BCAT2	-0.999274309287242
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	1/1105	22/9376	0.385684903331962	AOC1	-1.05436653345852
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	9/1105	116/9376	0.658324231549384	GLUL/SLC38A2/PLA2G4A/PPP3CC/CACNA1C/GNAI1/HOMER1/SLC1A3/GNG12	-1.35339774307402
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	5/1105	73/9376	0.581169032418025	UGT2B7/CYP3A5/UGT2B4/MGST1/GSTM3	-1.31303551030858
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	1/1105	23/9376	0.368915994491442	ATP1A1	-1.10755012638035
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	3/1105	50/9376	0.50910407239819	IL15RA/TGFB1/HLA-DRB5	-1.2720801994941
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	27/1105	298/9376	0.768781317379817	IL1RL1/PRLR/INHBA/CCL21/IL15RA/IFNGR2/IL6ST/IFNGR1/IL6R/OSMR/IFNAR1/BMPR2/TGFB2/TNFRSF21/IL13RA1/TGFBR1/BMP2/TGFB1/RELL1/IL18/IL16/ACVR1B/TNFRSF12A/CSF2RB/IL18R1/CSH2/IL20RB	-1.48259909974387
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	7/1105	97/9376	0.61232448570229	CAMK2D/FOS/RASD1/CACNA1C/GNAI1/PER1/GNG12	-1.4027859850157
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	3/1105	51/9376	0.499121639606069	ATP6V1E1/TJP1/ARF1	-1.31093362689416
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	1/1105	24/9376	0.353544494720965	XYLT1	-1.15899023505272
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	7/1105	99/9376	0.599954294071941	PIK3R1/PLA2G4A/CAMK2D/KNG1/MAPK8/PTGER2/PLA2G6	-1.46255160534627
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	3/1105	54/9376	0.471392659627954	HLA-G/HLA-E/HLA-DRB5	-1.42384687683637
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	1/1105	26/9376	0.326348764357814	SLC2A2	-1.25719818704967
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	4/1105	67/9376	0.506571216316607	ALDOB/PGK1/HK1/ACSS2	-1.48148798284272
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/1105	79/9376	0.537029612234378	UGT2B7/CYP3A5/UGT2B4/MGST1/GSTM3	-1.5103691653399
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	7/1105	102/9376	0.582308579540413	PLA2G5/KCNMA1/PLA2G2A/RAP1A/RAP1B/SLC4A2/ATP1A1	-1.5502789912173
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	2/1105	42/9376	0.404050851109675	DLST/AOC1	-1.41477610971386
NA	NA	hsa04081	Hormone signaling	18/1105	219/9376	0.69740283890163	PRLR/INSR/PIK3R1/JAK2/IGF1R/CRH/ADIPOR1/SMAD4/GNA11/ADRA2C/IRS2/ESR2/RAMP1/GNAI1/STK11/ITGAV/CSH2/GNG12	-1.65614388875694
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	1/1105	27/9376	0.314261773085302	AACS	-1.30420370357912
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	4/1105	68/9376	0.499121639606069	UGT2B7/CYP3A5/UGT2B4/DHRS3	-1.51511746699358
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	1/1105	28/9376	0.303038138332256	ATP6V1E1	-1.34994614930632
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	5/1105	82/9376	0.517382187396535	UGT2B7/UGT2B4/MGST1/GSTM3/CDADC1	-1.60434108692973
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	12/1105	160/9376	0.636380090497737	HLA-G/NECTIN2/VSIR/NFASC/F11R/SDC1/HLA-E/HLA-DRB5/CLDN11/ITGAV/PVR/NRXN3	-1.69560301245819
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	3/1105	59/9376	0.431444129151008	NT5C2/NT5C3B/CDADC1	-1.60121213662785
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	2/1105	46/9376	0.368915994491442	PSMD14/PSME3	-1.56824183153206
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	2/1105	47/9376	0.361066718012901	ACYP2/ACSS2	-1.60499860886734
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	6/1105	99/9376	0.51424653777595	CFH/C1S/KRT18/PLG/HLA-DRB5/FCGR2B	-1.77589584252669
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	5/1105	87/9376	0.487647578925469	TNNT2/CACNA1C/TPM2/ATP1A1/TPM4	-1.75481648038026
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/1105	100/9376	0.50910407239819	CCL21/IL6ST/IL6R/IL18/IL18R1/IL20RB	-1.80383506959329
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	6/1105	100/9376	0.50910407239819	CD59/IL6R/CD44/ITGA5/HLA-DRB5/CD55	-1.80383506959329
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	4/1105	76/9376	0.446582519647535	SLC4A2/CAMK2D/GNAI1/ATP1A1	-1.77054089126125
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	22/1105	275/9376	0.678805429864253	MT-ATP8/MT-ND4L/C7/PIK3R1/HSPA1A/CREB3L1/TUBA1C/ATF4/CSNK2A2/MAPK8/TUBB4B/PPIF/MCU/PPP3CC/CACNA1C/TUBB6/EIF2AK3/CAV1/PSMD14/MT-ND6/CREB3/TUBB2A	-1.97595819180648
Human Diseases	Substance dependence	hsa05032	Morphine addiction	5/1105	91/9376	0.466212520511163	PDE1C/GNAI1/GRK5/PDE8A/GNG12	-1.87019069423219
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	18/1105	238/9376	0.64172782235066	C7/PIK3R1/C1S/IL6ST/IL6R/TAB2/IFNAR1/TBK1/MAPK8/MAVS/FOS/ADAM17/IKBKB/NFKBIB/NFKBIA/RELA/STAT1/HBEGF	-2.04627383883134
NA	NA	hsa04382	Cornified envelope formation	16/1105	217/9376	0.625627124298851	PCSK6/PPP2R5E/DST/TJP1/KRT18/PPP2R2D/FURIN/PLEC/PPP2R3C/JUP/PPP2R2A/CLDN11/PPP2R5A/KDSR/TCHH/COL4A1	-2.03937917230044
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	1/1105	37/9376	0.229326158737923	PNMT	-1.71675791851509
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	4/1105	85/9376	0.399297311684855	NT5C2/NT5C3B/AK2/ADK	-2.03341290355584
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	12/1105	183/9376	0.556397893331355	SBDS/GNL3/XRN1/CSNK2A2/WDR43/NOP58/NXF1/REXO2/GNL2/UTP4/MDN1/NAT10	-2.2150232112205
Human Diseases	Substance dependence	hsa05034	Alcoholism	12/1105	191/9376	0.533093269526901	CRH/RAF1/BRAF/CREB3L1/ATF4/HDAC5/GNAI1/ARAF/CREB3/CAMKK2/HDAC6/GNG12	-2.38284067260141
Organismal Systems	Digestive system	hsa04970	Salivary secretion	4/1105	93/9376	0.364949155840996	KCNMA1/SLC4A2/LYZ/ATP1A1	-2.24953918972162
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	8/1105	149/9376	0.455574114002855	MT-ND4L/PTGS2/CNR1/MAPK8/CACNA1C/GNAI1/MT-ND6/GNG12	-2.44843966928181
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	6/1105	128/9376	0.397737556561086	NT5C2/PDE1C/AK2/PAPSS1/ADK/PDE8A	-2.50757899271575
Organismal Systems	Sensory system	hsa04742	Taste transduction	3/1105	86/9376	0.29599073976639	CACNA1C/PDE1C/SCNN1A	-2.39721787359107
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	6/1105	138/9376	0.368915994491442	MT-ATP8/MT-ND4L/ATP6V1E1/MT-ND6/COX10/LHPP	-2.7297665291693
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	9/1105	195/9376	0.391618517229377	PIK3R1/AKT3/CASP4/RAF1/PPIF/HDAC5/RELA/HDAC6/MTOR	-3.13787808304316
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	3/1105	143/9376	0.178008416922444	C7/C1S/HLA-DRB5	-3.62035983651397
NA	NA	hsa04082	Neuroactive ligand signaling	6/1105	199/9376	0.255831192159894	TAC3/GNA11/ADRA2C/GNAI1/SLC1A3/GNG12	-3.87824643167315
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	16/1105	370/9376	0.366921853980678	PRLR/LPAR1/TAC3/CRH/PGRMC1/S1PR2/KNG1/CNR1/PLG/PTGER2/ADRA2C/PGRMC2/S1PR3/F2R/PTGER3/CSH2	-4.54129777126635
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	2/1105	449/9376	0.0377954025536889	CAMK2D/PDE1C	-7.63704936002374