ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 126/2155 495/18639 0.254545454545455 2.2016114743725 2.91824627807724e-18 3.59819766086924e-15 GO:0045296 cadherin binding 88/2155 334/18639 0.263473053892216 2.27882795893133 4.68750300695704e-14 2.88984560378902e-11 GO:0140297 DNA-binding transcription factor binding 109/2155 488/18639 0.223360655737705 1.93188828876802 6.02295056516181e-12 2.4754326822815e-09 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 85/2155 349/18639 0.243553008595989 2.10653574348985 1.24988650022721e-11 3.85277513695038e-09 GO:0003713 transcription coactivator activity 66/2155 256/18639 0.2578125 2.22986876450116 1.90006905861759e-10 4.68557029855098e-08 GO:0032182 ubiquitin-like protein binding 40/2155 120/18639 0.333333333333333 2.8830626450116 2.29356313774011e-10 4.71327224805594e-08 GO:0019787 ubiquitin-like protein transferase activity 101/2155 479/18639 0.210855949895616 1.82373273786746 1.08658956988227e-09 1.91394991380692e-07 GO:0016755 aminoacyltransferase activity 103/2155 496/18639 0.207661290322581 1.79610152683182 1.7854308256338e-09 2.7517952600081e-07 GO:0044389 ubiquitin-like protein ligase binding 74/2155 322/18639 0.229813664596273 1.98770157513222 4.17355960839912e-09 5.71777666350679e-07 GO:0031625 ubiquitin protein ligase binding 70/2155 302/18639 0.231788079470199 2.00477866043853 7.49478578356852e-09 9.24107087113999e-07 GO:0043130 ubiquitin binding 33/2155 100/18639 0.33 2.85423201856148 1.12177532683671e-08 1.1903102531906e-06 GO:0141003 histone H2AX kinase activity 78/2155 354/18639 0.220338983050847 1.90575327382123 1.17571138998078e-08 1.1903102531906e-06 GO:0004842 ubiquitin-protein transferase activity 93/2155 449/18639 0.207126948775056 1.79147990636578 1.25499053458863e-08 1.1903102531906e-06 GO:0001098 basal transcription machinery binding 24/2155 60/18639 0.4 3.45967517401392 1.60569373533445e-08 1.24523679645765e-06 GO:0001099 basal RNA polymerase II transcription machinery binding 24/2155 60/18639 0.4 3.45967517401392 1.60569373533445e-08 1.24523679645765e-06 GO:0060589 nucleoside-triphosphatase regulator activity 99/2155 490/18639 0.202040816326531 1.74748899095601 1.61587905460847e-08 1.24523679645765e-06 GO:0140996 histone H3 kinase activity 78/2155 357/18639 0.218487394957983 1.88973854042777 1.7344418688835e-08 1.25798048490197e-06 GO:0003714 transcription corepressor activity 52/2155 204/18639 0.254901960784314 2.2046949638324 2.36006348427303e-08 1.61664348672703e-06 GO:0035173 histone kinase activity 78/2155 360/18639 0.216666666666667 1.87399071925754 2.54080521930216e-08 1.64884886073661e-06 GO:0030695 GTPase regulator activity 98/2155 489/18639 0.20040899795501 1.73337508718489 2.90972588247162e-08 1.79384600654375e-06 GO:0004674 protein serine/threonine kinase activity 88/2155 433/18639 0.203233256351039 1.75780262882924 7.652172484887e-08 4.49291841612651e-06 GO:0061659 ubiquitin-like protein ligase activity 78/2155 372/18639 0.209677419354839 1.8135394057331 1.09365410660122e-07 6.12943415199683e-06 GO:0106310 protein serine kinase activity 76/2155 361/18639 0.210526315789474 1.82088167053364 1.33567900750222e-07 7.1604009402184e-06 GO:0019207 kinase regulator activity 64/2155 287/18639 0.222996515679443 1.92873877296943 1.49394877787085e-07 7.67516184631147e-06 GO:0042393 histone binding 57/2155 247/18639 0.230769230769231 1.99596644654649 2.11883261142809e-07 1.04500824395633e-05 GO:0070063 RNA polymerase binding 22/2155 59/18639 0.372881355932203 3.22512092492823 2.75465200774249e-07 1.30634074059481e-05 GO:0043175 RNA polymerase core enzyme binding 18/2155 42/18639 0.428571428571429 3.70679482930063 2.88857527395868e-07 1.31911604177446e-05 GO:0140857 histone H3T45 kinase activity 56/2155 246/18639 0.227642276422764 1.96892083073963 4.33818957614736e-07 1.91035276692489e-05 GO:0004679 AMP-activated protein kinase activity 56/2155 248/18639 0.225806451612903 1.95304243694334 5.73045681172277e-07 2.16100275403114e-05 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 55/2155 243/18639 0.226337448559671 1.95763512932886 6.65604395502211e-07 2.16100275403114e-05 GO:0000993 RNA polymerase II complex binding 16/2155 36/18639 0.444444444444444 3.84408352668213 7.26241689255032e-07 2.16100275403114e-05 GO:0140296 general transcription initiation factor binding 20/2155 53/18639 0.377358490566038 3.26384450378672 7.631105671294e-07 2.16100275403114e-05 GO:0140030 modification-dependent protein binding 43/2155 173/18639 0.248554913294798 2.14979815726299 7.86876184107351e-07 2.16100275403114e-05 GO:0004676 3-phosphoinositide-dependent protein kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0004711 ribosomal protein S6 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0035175 histone H3S10 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0035979 histone H2AXS139 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0044022 histone H3S28 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0044023 histone H4S1 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0044024 histone H2AS1 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0044025 histone H2BS14 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0072354 histone H3T3 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0072371 histone H2AS121 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0072518 Rho-dependent protein serine/threonine kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0140823 histone H2BS36 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0140855 histone H3S57 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0140995 histone H2A kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0140997 histone H4 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0140998 histone H2B kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:1990244 histone H2AT120 kinase activity 55/2155 245/18639 0.224489795918367 1.94165443439557 8.76319040564127e-07 2.16100275403114e-05 GO:0004677 DNA-dependent protein kinase activity 55/2155 246/18639 0.223577235772358 1.93376153019071 1.00374053041867e-06 2.42669034118866e-05 GO:0035402 histone H3T11 kinase activity 55/2155 247/18639 0.222672064777328 1.92593253614135 1.14835942704748e-06 2.67156070481046e-05 GO:0035403 histone H3T6 kinase activity 55/2155 247/18639 0.222672064777328 1.92593253614135 1.14835942704748e-06 2.67156070481046e-05 GO:0001221 transcription coregulator binding 32/2155 115/18639 0.278260869565217 2.40673055583577 1.47141249989328e-06 3.35972520808965e-05 GO:0019887 protein kinase regulator activity 55/2155 255/18639 0.215686274509804 1.8655111232428 3.23726311435197e-06 7.2573553090836e-05 GO:0061630 ubiquitin protein ligase activity 70/2155 353/18639 0.198300283286119 1.71513641771228 3.98819960732499e-06 8.78116092112806e-05 GO:0141052 histone H3 demethylase activity 13/2155 28/18639 0.464285714285714 4.01569439840902 4.42959821948713e-06 9.58192035899584e-05 GO:0005096 GTPase activator activity 57/2155 271/18639 0.210332103321033 1.81920189039477 4.90424606126264e-06 0.000104257506785118 GO:0046332 SMAD binding 24/2155 79/18639 0.30379746835443 2.62760139798526 5.65269707957932e-06 0.0001181317881207 GO:0032452 histone demethylase activity 13/2155 30/18639 0.433333333333333 3.74798143851508 1.13302614196173e-05 0.000232836872173136 GO:0001223 transcription coactivator binding 16/2155 44/18639 0.363636363636364 3.14515924910356 1.67480262061801e-05 0.000338529775610165 GO:0140457 protein demethylase activity 13/2155 31/18639 0.419354838709677 3.62707881146621 1.74520892281708e-05 0.000347071387392493 GO:0032451 demethylase activity 15/2155 40/18639 0.375 3.24344547563805 2.00004679724349e-05 0.000391437730317654 GO:0002020 protease binding 33/2155 136/18639 0.242647058823529 2.09870001364815 2.46357839037965e-05 0.00047462377427158 GO:0019209 kinase activator activity 35/2155 148/18639 0.236486486486486 2.04541606571769 2.55538561051059e-05 0.000484736993501471 GO:0016922 nuclear receptor binding 33/2155 137/18639 0.240875912408759 2.08338103544634 2.89017493992259e-05 0.000539937227412812 GO:0031490 chromatin DNA binding 31/2155 128/18639 0.2421875 2.09472520301624 4.45341544873077e-05 0.00081956138034105 GO:0019838 growth factor binding 32/2155 136/18639 0.235294117647059 2.0351030435376 6.18157931180827e-05 0.00112086577815582 GO:0030295 protein kinase activator activity 32/2155 139/18639 0.23021582733813 1.99117995626701 9.64271285850999e-05 0.00172311086297722 GO:0019902 phosphatase binding 40/2155 190/18639 0.210526315789474 1.82088167053364 0.000117467148991132 0.00206909992437236 GO:0031369 translation initiation factor binding 12/2155 32/18639 0.375 3.24344547563805 0.000134942429323427 0.00234343683599698 GO:0005085 guanyl-nucleotide exchange factor activity 46/2155 230/18639 0.2 1.72983758700696 0.000137743601751277 0.00235885917999062 GO:0036408 histone H3K14 acetyltransferase activity 11/2155 28/18639 0.392857142857143 3.39789526019224 0.000157787376116593 0.00266509362673642 GO:0004402 histone acetyltransferase activity 14/2155 42/18639 0.333333333333333 2.8830626450116 0.000165985111589695 0.00276567084581208 GO:0030275 LRR domain binding 8/2155 16/18639 0.5 4.3245939675174 0.000171908419718635 0.00278898791464576 GO:0034450 ubiquitin-ubiquitin ligase activity 8/2155 16/18639 0.5 4.3245939675174 0.000171908419718635 0.00278898791464576 GO:0019210 kinase inhibitor activity 23/2155 90/18639 0.255555555555556 2.21034802784223 0.000175654001239442 0.00279206365892639 GO:0140033 acetylation-dependent protein binding 10/2155 24/18639 0.416666666666667 3.6038283062645 0.000176626898131596 0.00279206365892639 GO:1990841 promoter-specific chromatin binding 19/2155 68/18639 0.279411764705882 2.4166848642009 0.000180487895594882 0.00281698196542391 GO:0140416 transcription regulator inhibitor activity 12/2155 33/18639 0.363636363636364 3.14515924910356 0.000189878565910739 0.00292650339709927 GO:0019903 protein phosphatase binding 32/2155 144/18639 0.222222222222222 1.92204176334107 0.000194057799487501 0.00295399094775418 GO:0140693 molecular condensate scaffold activity 15/2155 48/18639 0.3125 2.70287122969838 0.000221549265709527 0.00330389382560048 GO:0002039 p53 binding 19/2155 69/18639 0.27536231884058 2.38166044587915 0.000222403234002303 0.00330389382560048 GO:0010484 histone H3 acetyltransferase activity 11/2155 29/18639 0.379310344827586 3.28072645811665 0.000227797080746705 0.00333899233053767 GO:0019783 ubiquitin-like protein peptidase activity 29/2155 127/18639 0.228346456692913 1.97501141823629 0.000232476077456309 0.00333899233053767 GO:0101005 deubiquitinase activity 27/2155 115/18639 0.234782608695652 2.03067890648643 0.000232889976014793 0.00333899233053767 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 45/2155 229/18639 0.196506550218341 1.69962208330378 0.000245367868853338 0.00347745496892145 GO:0031994 insulin-like growth factor I binding 7/2155 13/18639 0.538461538461538 4.65725504194182 0.000248979873179394 0.00348854754125219 GO:0032183 SUMO binding 8/2155 17/18639 0.470588235294118 4.0702060870752 0.000291845952792449 0.00404321415497853 GO:0043995 histone H4K5 acetyltransferase activity 11/2155 30/18639 0.366666666666667 3.17136890951276 0.000322343346468992 0.00432010158908986 GO:0043996 histone H4K8 acetyltransferase activity 11/2155 30/18639 0.366666666666667 3.17136890951276 0.000322343346468992 0.00432010158908986 GO:0043997 histone H4K12 acetyltransferase activity 11/2155 30/18639 0.366666666666667 3.17136890951276 0.000322343346468992 0.00432010158908986 GO:0099122 RNA polymerase II C-terminal domain binding 6/2155 10/18639 0.6 5.18951276102088 0.000329241946999944 0.0043651109747412 GO:0010485 histone H4 acetyltransferase activity 12/2155 35/18639 0.342857142857143 2.9654358634405 0.000358161090899138 0.00466193727962406 GO:0004386 helicase activity 33/2155 155/18639 0.212903225806452 1.84144001197515 0.000359192247821805 0.00466193727962406 GO:0070325 lipoprotein particle receptor binding 11/2155 31/18639 0.354838709677419 3.06906668662525 0.000447823296905671 0.00569820156342416 GO:0032454 histone H3K9 demethylase activity 7/2155 14/18639 0.5 4.3245939675174 0.000448277008639208 0.00569820156342416 GO:0004860 protein kinase inhibitor activity 21/2155 84/18639 0.25 2.1622969837587 0.000455304975710676 0.00572847994950268 GO:0004843 cysteine-type deubiquitinase activity 25/2155 108/18639 0.231481481481481 2.00212683681361 0.00048952410868712 0.00609680026273958 GO:0140658 ATP-dependent chromatin remodeler activity 33/2155 158/18639 0.208860759493671 1.80647596111486 0.000515802450590245 0.00635984421577772 GO:0004713 protein tyrosine kinase activity 30/2155 140/18639 0.214285714285714 1.85339741465031 0.00058025742533281 0.00708373668747876 GO:0008201 heparin binding 35/2155 172/18639 0.203488372093023 1.76000917282685 0.000589987325704261 0.00713190561366033 GO:0061733 protein-lysine-acetyltransferase activity 14/2155 47/18639 0.297872340425532 2.57635385298909 0.000614932601091441 0.00729049901101679 GO:0140938 histone H3 methyltransferase activity 14/2155 47/18639 0.297872340425532 2.57635385298909 0.000614932601091441 0.00729049901101679 GO:0043394 proteoglycan binding 12/2155 37/18639 0.324324324324324 2.80514203298426 0.000638013368078899 0.00749209983658364 GO:0070577 lysine-acetylated histone binding 9/2155 23/18639 0.391304347826087 3.38446484414405 0.000650374268832199 0.00752923281172433 GO:0043522 leucine zipper domain binding 6/2155 11/18639 0.545454545454545 4.71773887365535 0.000653388411074212 0.00752923281172433 GO:0051020 GTPase binding 56/2155 315/18639 0.177777777777778 1.53763341067285 0.000679598600122775 0.00775875068473501 GO:0005520 insulin-like growth factor binding 8/2155 19/18639 0.421052631578947 3.64176334106729 0.000733375456658901 0.0082958893400039 GO:0061578 K63-linked deubiquitinase activity 7/2155 15/18639 0.466666666666667 4.03628770301624 0.000756823751012357 0.00848330622725669 GO:0031593 polyubiquitin modification-dependent protein binding 16/2155 59/18639 0.271186440677966 2.3455424908569 0.000817115639599744 0.00907660886149986 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 12/2155 38/18639 0.315789473684211 2.73132250580046 0.000835436275639069 0.00917973450869845 GO:0031267 small GTPase binding 51/2155 283/18639 0.180212014134276 1.5586875783985 0.000841289537293532 0.00917973450869845 GO:0005543 phospholipid binding 81/2155 497/18639 0.162977867203219 1.40962620269179 0.000864034093773223 0.0093452108563367 GO:0035091 phosphatidylinositol binding 51/2155 284/18639 0.179577464788732 1.55319924185484 0.000912753128597161 0.00978630093530695 GO:0001091 RNA polymerase II general transcription initiation factor binding 9/2155 24/18639 0.375 3.24344547563805 0.00093462269125256 0.00984948528473852 GO:0048027 mRNA 5'-UTR binding 9/2155 24/18639 0.375 3.24344547563805 0.00093462269125256 0.00984948528473852 GO:0003724 RNA helicase activity 19/2155 77/18639 0.246753246753247 2.13421520474885 0.000988846945050098 0.0100467294552178 GO:0008094 ATP-dependent activity, acting on DNA 40/2155 210/18639 0.19047619047619 1.64746436857806 0.000994056942848545 0.0100467294552178 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 16/2155 60/18639 0.266666666666667 2.30645011600928 0.000996414438694452 0.0100467294552178 GO:0000510 H3-H4 histone complex chaperone activity 31/2155 151/18639 0.205298013245033 1.77566109924556 0.00101098596375667 0.0100467294552178 GO:0140584 chromatin extrusion motor activity 31/2155 151/18639 0.205298013245033 1.77566109924556 0.00101098596375667 0.0100467294552178 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 31/2155 151/18639 0.205298013245033 1.77566109924556 0.00101098596375667 0.0100467294552178 GO:0140849 ATP-dependent H2AZ histone chaperone activity 31/2155 151/18639 0.205298013245033 1.77566109924556 0.00101098596375667 0.0100467294552178 GO:0140713 histone chaperone activity 33/2155 164/18639 0.201219512195122 1.74038537717164 0.00101852488394341 0.0100467294552178 GO:0140767 enzyme-substrate adaptor activity 29/2155 139/18639 0.20863309352518 1.80450683536697 0.00111012939966222 0.0108214730305942 GO:0003779 actin binding 73/2155 443/18639 0.164785553047404 1.42526121728564 0.00111681489082287 0.0108214730305942 GO:0015616 DNA translocase activity 31/2155 152/18639 0.203947368421053 1.76397911832947 0.0011321735774101 0.0108214730305942 GO:0140674 ATP-dependent histone chaperone activity 31/2155 152/18639 0.203947368421053 1.76397911832947 0.0011321735774101 0.0108214730305942 GO:0016407 acetyltransferase activity 22/2155 96/18639 0.229166666666667 1.98210556844548 0.00119440467055133 0.0113284689137676 GO:0055102 lipase inhibitor activity 7/2155 16/18639 0.4375 3.78401972157773 0.00121175789757414 0.0114053243336558 GO:0061775 cohesin loader activity 31/2155 153/18639 0.202614379084967 1.75244984304627 0.00126581419690439 0.011823855339266 GO:0003689 DNA clamp loader activity 32/2155 160/18639 0.2 1.72983758700696 0.00133653395924357 0.0123905742236641 GO:0008186 ATP-dependent activity, acting on RNA 19/2155 79/18639 0.240506329113924 2.08018444007166 0.00137403585441908 0.0126428295098965 GO:0004532 RNA exonuclease activity 12/2155 40/18639 0.3 2.59475638051044 0.00138425140619305 0.0126428295098965 GO:0051721 protein phosphatase 2A binding 10/2155 30/18639 0.333333333333333 2.8830626450116 0.00141094772767001 0.0127408206057988 GO:0000175 3'-5'-RNA exonuclease activity 11/2155 35/18639 0.314285714285714 2.71831620815379 0.0014259799218169 0.0127408206057988 GO:0061631 ubiquitin conjugating enzyme activity 11/2155 35/18639 0.314285714285714 2.71831620815379 0.0014259799218169 0.0127408206057988 GO:0005539 glycosaminoglycan binding 44/2155 242/18639 0.181818181818182 1.57257962455178 0.00153341869071887 0.0136021960119163 GO:0140597 protein carrier chaperone 36/2155 188/18639 0.191489361702128 1.65622747692156 0.00156931241805836 0.0138211586533283 GO:0031491 nucleosome binding 18/2155 74/18639 0.243243243243243 2.1038565247382 0.00158306028666852 0.0138433569749098 GO:0035613 RNA stem-loop binding 8/2155 21/18639 0.380952380952381 3.29492873715612 0.00159705183900207 0.01386735857387 GO:0140318 protein transporter activity 12/2155 41/18639 0.292682926829268 2.53146963952238 0.00175399369024335 0.0151235959445458 GO:0043548 phosphatidylinositol 3-kinase binding 9/2155 26/18639 0.346153846153846 2.99394966981974 0.00180262039583854 0.0154349371393675 GO:0019003 GDP binding 18/2155 75/18639 0.24 2.07580510440835 0.00186192409669885 0.0158327752498599 GO:0008408 3'-5' exonuclease activity 15/2155 58/18639 0.258620689655172 2.2368589487159 0.00197805619271163 0.0167050909973524 GO:0034212 protein N-acetyltransferase activity 14/2155 53/18639 0.264150943396226 2.2846911526507 0.00222597148112111 0.0173987404462434 GO:0032931 histone H3K56 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0043992 histone H3K9 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0043993 histone H3K18 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0043994 histone H3K23 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0043999 histone H2AK5 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0044012 histone H2AK9 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0044014 histone H2BK5 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0044015 histone H2BK12 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0044016 histone H3K4 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0044017 histone H3K27 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0044018 histone H3K36 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0046972 histone H4K16 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0140908 histone H3K122 acetyltransferase activity 8/2155 22/18639 0.363636363636364 3.14515924910356 0.00225774409683613 0.0173987404462434 GO:0008320 protein transmembrane transporter activity 9/2155 27/18639 0.333333333333333 2.8830626450116 0.00242978956111345 0.0184672785895721 GO:0022884 macromolecule transmembrane transporter activity 10/2155 32/18639 0.3125 2.70287122969838 0.00244133528799696 0.0184672785895721 GO:0051059 NF-kappaB binding 10/2155 32/18639 0.3125 2.70287122969838 0.00244133528799696 0.0184672785895721 GO:0003727 single-stranded RNA binding 20/2155 89/18639 0.224719101123595 1.94363773821007 0.00250085530734275 0.0188021621582537 GO:0008234 cysteine-type peptidase activity 35/2155 187/18639 0.18716577540107 1.61883196645036 0.00268990063157719 0.0200904696514348 GO:0003697 single-stranded DNA binding 25/2155 121/18639 0.206611570247934 1.78702230062703 0.00270479964488092 0.0200904696514348 GO:0000900 mRNA regulatory element binding translation repressor activity 7/2155 18/18639 0.388888888888889 3.36357308584687 0.0027360825547111 0.0202011364668191 GO:0098531 ligand-modulated transcription factor activity 15/2155 60/18639 0.25 2.1622969837587 0.00283297036213185 0.0205594419373422 GO:0035401 histone H3Y41 kinase activity 24/2155 115/18639 0.208695652173913 1.80504791687683 0.0028346351414016 0.0205594419373422 GO:0140801 histone H2AXY142 kinase activity 24/2155 115/18639 0.208695652173913 1.80504791687683 0.0028346351414016 0.0205594419373422 GO:0044013 histone H2B acetyltransferase activity 8/2155 23/18639 0.347826086956522 3.00841319479471 0.00311500800510488 0.0222355108855969 GO:0061665 SUMO ligase activity 6/2155 14/18639 0.428571428571429 3.70679482930063 0.00312239663483739 0.0222355108855969 GO:0008190 eukaryotic initiation factor 4E binding 5/2155 10/18639 0.5 4.3245939675174 0.00313785798385553 0.0222355108855969 GO:0051864 histone H3K36 demethylase activity 5/2155 10/18639 0.5 4.3245939675174 0.00313785798385553 0.0222355108855969 GO:0001046 core promoter sequence-specific DNA binding 12/2155 44/18639 0.272727272727273 2.35886943682767 0.003374181375378 0.0237735179190918 GO:1990380 K48-linked deubiquitinase activity 7/2155 19/18639 0.368421052631579 3.18654292343387 0.00390432836190822 0.0273524822172321 GO:0043998 histone H2A acetyltransferase activity 8/2155 24/18639 0.333333333333333 2.8830626450116 0.00420520066203105 0.0292938554592332 GO:0016504 peptidase activator activity 14/2155 57/18639 0.245614035087719 2.12436194895592 0.00458376369533352 0.0317515766086867 GO:0140104 molecular carrier activity 43/2155 249/18639 0.172690763052209 1.49363486428312 0.00461852396064933 0.0318136315278247 GO:0008080 N-acetyltransferase activity 16/2155 69/18639 0.231884057971014 2.00560879652981 0.00467785369208428 0.0320432977907773 GO:0016410 N-acyltransferase activity 20/2155 94/18639 0.212765957446809 1.84025275213506 0.00485759463227134 0.0330906860861357 GO:0140566 histone reader activity 10/2155 35/18639 0.285714285714286 2.47119655286709 0.00503137437451565 0.0340861791416363 GO:0180030 inositol phosphate kinase activity 5/2155 11/18639 0.454545454545455 3.93144906137946 0.00520824929450663 0.0350916468859381 GO:0008187 poly-pyrimidine tract binding 9/2155 30/18639 0.3 2.59475638051044 0.00538795534585078 0.0361051572904023 GO:0008139 nuclear localization sequence binding 8/2155 25/18639 0.32 2.76774013921114 0.00556678137392449 0.0365097948619622 GO:0017056 structural constituent of nuclear pore 8/2155 25/18639 0.32 2.76774013921114 0.00556678137392449 0.0365097948619622 GO:0042974 nuclear retinoic acid receptor binding 8/2155 25/18639 0.32 2.76774013921114 0.00556678137392449 0.0365097948619622 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 8/2155 25/18639 0.32 2.76774013921114 0.00556678137392449 0.0365097948619622 GO:0005496 steroid binding 22/2155 108/18639 0.203703703703704 1.76187161639598 0.005610980547322 0.036550240775675 GO:0061650 ubiquitin-like protein conjugating enzyme activity 11/2155 41/18639 0.268292682926829 2.32051383622885 0.00563223499381853 0.036550240775675 GO:0008135 translation factor activity, RNA binding 18/2155 83/18639 0.216867469879518 1.87572750398345 0.00594713355602339 0.0383917051024966 GO:0004879 nuclear receptor activity 14/2155 59/18639 0.23728813559322 2.05234967949978 0.00635832566635738 0.0408323726386388 GO:0180051 translation factor activity 18/2155 84/18639 0.214285714285714 1.85339741465031 0.00677067690657151 0.0429467027968643 GO:0043021 ribonucleoprotein complex binding 32/2155 177/18639 0.180790960451977 1.5636949939046 0.00678164649560709 0.0429467027968643 GO:0070411 I-SMAD binding 6/2155 16/18639 0.375 3.24344547563805 0.00679205761994204 0.0429467027968643 GO:0005160 transforming growth factor beta receptor binding 8/2155 26/18639 0.307692307692308 2.66128859539532 0.00723974180862936 0.0448572947238191 GO:0008143 poly(A) binding 8/2155 26/18639 0.307692307692308 2.66128859539532 0.00723974180862936 0.0448572947238191 GO:0050750 low-density lipoprotein particle receptor binding 8/2155 26/18639 0.307692307692308 2.66128859539532 0.00723974180862936 0.0448572947238191 GO:0070412 R-SMAD binding 8/2155 26/18639 0.307692307692308 2.66128859539532 0.00723974180862936 0.0448572947238191 GO:0140463 chromatin-protein adaptor activity 13/2155 54/18639 0.240740740740741 2.08221191028616 0.00739169570123367 0.0455698039981056 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 14/2155 60/18639 0.233333333333333 2.01814385150812 0.00743125988938254 0.0455857882766601 GO:0035014 phosphatidylinositol 3-kinase regulator activity 5/2155 12/18639 0.416666666666667 3.6038283062645 0.00808621325188262 0.0491147829535531 GO:0070410 co-SMAD binding 5/2155 12/18639 0.416666666666667 3.6038283062645 0.00808621325188262 0.0491147829535531 GO:0048156 tau protein binding 11/2155 43/18639 0.255813953488372 2.21258296012518 0.0082634907754837 0.0497810719405842 GO:0043539 protein serine/threonine kinase activator activity 16/2155 73/18639 0.219178082191781 1.89571242411722 0.00827665835184085 0.0497810719405842 GO:0050840 extracellular matrix binding 15/2155 67/18639 0.223880597014925 1.93638535858988 0.00849904495223642 0.0507930875673031 GO:0070717 poly-purine tract binding 9/2155 32/18639 0.28125 2.43258410672854 0.0085435350479694 0.0507930875673031 GO:0001222 transcription corepressor binding 12/2155 49/18639 0.244897959183673 2.11816847388607 0.00856850139010466 0.0507930875673031 GO:0000287 magnesium ion binding 39/2155 230/18639 0.169565217391304 1.46660143246242 0.00910431996245164 0.0537111316445113 GO:0042162 telomeric DNA binding 10/2155 38/18639 0.263157894736842 2.27610208816705 0.00939709905340206 0.0551743958706892 GO:0035064 methylated histone binding 16/2155 74/18639 0.216216216216216 1.87009468865617 0.00945517595193443 0.0552522841172282 GO:0008093 cytoskeletal anchor activity 7/2155 22/18639 0.318181818181818 2.75201434296562 0.00968776373381912 0.0560798717549248 GO:0070034 telomerase RNA binding 7/2155 22/18639 0.318181818181818 2.75201434296562 0.00968776373381912 0.0560798717549248 GO:0032934 sterol binding 15/2155 68/18639 0.220588235294118 1.9079091033165 0.00976814662388591 0.0562809569497726 GO:0016248 channel inhibitor activity 11/2155 44/18639 0.25 2.1622969837587 0.00989326057551894 0.0567366990214644 GO:0003725 double-stranded RNA binding 16/2155 75/18639 0.213333333333333 1.84516009280742 0.0107630100185316 0.0614388488557846 GO:0004197 cysteine-type endopeptidase activity 18/2155 88/18639 0.204545454545455 1.76915207762076 0.0110344973298325 0.0626983189294171 GO:0019789 SUMO transferase activity 8/2155 28/18639 0.285714285714286 2.47119655286709 0.0116836715268754 0.0655299905302227 GO:0051019 mitogen-activated protein kinase binding 8/2155 28/18639 0.285714285714286 2.47119655286709 0.0116836715268754 0.0655299905302227 GO:0141110 transporter inhibitor activity 11/2155 45/18639 0.244444444444444 2.11424593967517 0.0117591940034434 0.0655299905302227 GO:0015932 nucleobase-containing compound transmembrane transporter activity 13/2155 57/18639 0.228070175438596 1.97262180974478 0.0117761666682568 0.0655299905302227 GO:0004535 poly(A)-specific ribonuclease activity 5/2155 13/18639 0.384615384615385 3.32661074424416 0.0119048806802675 0.0655299905302227 GO:0043560 insulin receptor substrate binding 5/2155 13/18639 0.384615384615385 3.32661074424416 0.0119048806802675 0.0655299905302227 GO:0140852 histone ubiquitin ligase activity 5/2155 13/18639 0.384615384615385 3.32661074424416 0.0119048806802675 0.0655299905302227 GO:0140034 methylation-dependent protein binding 16/2155 76/18639 0.210526315789474 1.82088167053364 0.0122094368758804 0.0669077140798244 GO:0035591 signaling adaptor activity 24/2155 129/18639 0.186046511627907 1.60915124372741 0.0123839974654066 0.0675640215701167 GO:0042171 lysophosphatidic acid acyltransferase activity 7/2155 23/18639 0.304347826086957 2.63236154544538 0.0125633443651316 0.0679412438693303 GO:0071617 lysophospholipid acyltransferase activity 7/2155 23/18639 0.304347826086957 2.63236154544538 0.0125633443651316 0.0679412438693303 GO:0070064 proline-rich region binding 6/2155 18/18639 0.333333333333333 2.8830626450116 0.0128588862661199 0.0686363929269518 GO:0098641 cadherin binding involved in cell-cell adhesion 6/2155 18/18639 0.333333333333333 2.8830626450116 0.0128588862661199 0.0686363929269518 GO:1990381 ubiquitin-specific protease binding 6/2155 18/18639 0.333333333333333 2.8830626450116 0.0128588862661199 0.0686363929269518 GO:0051015 actin filament binding 35/2155 209/18639 0.167464114832536 1.44842860156085 0.0155090213405317 0.0824251004865329 GO:0016251 RNA polymerase II general transcription initiation factor activity 12/2155 53/18639 0.226415094339623 1.95830670227203 0.0160749195995133 0.0847024609666661 GO:0051018 protein kinase A binding 12/2155 53/18639 0.226415094339623 1.95830670227203 0.0160749195995133 0.0847024609666661 GO:0043495 protein-membrane adaptor activity 11/2155 47/18639 0.234042553191489 2.02427802734857 0.0162808951465703 0.085422739215835 GO:0004065 arylsulfatase activity 5/2155 14/18639 0.357142857142857 3.08899569108386 0.0167840384832843 0.0873194913497447 GO:0098847 sequence-specific single stranded DNA binding 5/2155 14/18639 0.357142857142857 3.08899569108386 0.0167840384832843 0.0873194913497447 GO:0042800 histone H3K4 methyltransferase activity 6/2155 19/18639 0.315789473684211 2.73132250580046 0.0169917591449868 0.0880287354023898 GO:0140097 catalytic activity, acting on DNA 52/2155 336/18639 0.154761904761905 1.33856479946967 0.0174457400443689 0.0900024998941712 GO:0000149 SNARE binding 20/2155 106/18639 0.188679245283019 1.63192225189336 0.0182834967780045 0.093541707582073 GO:0008013 beta-catenin binding 20/2155 106/18639 0.188679245283019 1.63192225189336 0.0182834967780045 0.093541707582073 GO:0003925 G protein activity 12/2155 54/18639 0.222222222222222 1.92204176334107 0.0185558407133075 0.0945427752045789 GO:0005484 SNAP receptor activity 9/2155 36/18639 0.25 2.1622969837587 0.0188029501151742 0.0950165470984009 GO:0044390 ubiquitin-like protein conjugating enzyme binding 9/2155 36/18639 0.25 2.1622969837587 0.0188029501151742 0.0950165470984009 GO:0051219 phosphoprotein binding 18/2155 93/18639 0.193548387096774 1.67403637452287 0.0190893961423607 0.0960703079327784 GO:0042054 histone methyltransferase activity 14/2155 67/18639 0.208955223880597 1.80729300135056 0.0195078054594171 0.0977769273636639 GO:0017025 TBP-class protein binding 7/2155 25/18639 0.28 2.42177262180974 0.0200642141167534 0.0997547419595039 GO:0019211 phosphatase activator activity 7/2155 25/18639 0.28 2.42177262180974 0.0200642141167534 0.0997547419595039 GO:0008140 cAMP response element binding protein binding 4/2155 10/18639 0.4 3.45967517401392 0.0210687365176163 0.102274614670161 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 4/2155 10/18639 0.4 3.45967517401392 0.0210687365176163 0.102274614670161 GO:0015658 branched-chain amino acid transmembrane transporter activity 4/2155 10/18639 0.4 3.45967517401392 0.0210687365176163 0.102274614670161 GO:0031434 mitogen-activated protein kinase kinase binding 4/2155 10/18639 0.4 3.45967517401392 0.0210687365176163 0.102274614670161 GO:0042975 peroxisome proliferator activated receptor binding 4/2155 10/18639 0.4 3.45967517401392 0.0210687365176163 0.102274614670161 GO:0070513 death domain binding 4/2155 10/18639 0.4 3.45967517401392 0.0210687365176163 0.102274614670161 GO:0098632 cell-cell adhesion mediator activity 12/2155 55/18639 0.218181818181818 1.88709554946214 0.0213121651653377 0.10305058685828 GO:0004857 enzyme inhibitor activity 62/2155 416/18639 0.149038461538462 1.28906166339461 0.0215344157817646 0.103686078258583 GO:0005525 GTP binding 57/2155 378/18639 0.150793650793651 1.3042426251243 0.0216117778689828 0.103686078258583 GO:0015095 magnesium ion transmembrane transporter activity 6/2155 20/18639 0.3 2.59475638051044 0.0219533152082388 0.104511342284782 GO:0043024 ribosomal small subunit binding 6/2155 20/18639 0.3 2.59475638051044 0.0219533152082388 0.104511342284782 GO:0008200 ion channel inhibitor activity 10/2155 43/18639 0.232558139534884 2.01143905465926 0.0223927211724325 0.106193173867728 GO:0016887 ATP hydrolysis activity 62/2155 417/18639 0.148681055155875 1.28597038842244 0.0225284343583194 0.10627810632067 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 22/2155 122/18639 0.180327868852459 1.55968962762923 0.0225830201589746 0.10627810632067 GO:0140098 catalytic activity, acting on RNA 58/2155 387/18639 0.149870801033592 1.29626072411374 0.0230789572256759 0.108199065624557 GO:0008276 protein methyltransferase activity 18/2155 95/18639 0.189473684210526 1.63879350348028 0.0233534200425123 0.109071086789461 GO:0140272 exogenous protein binding 16/2155 82/18639 0.195121951219512 1.68764642634825 0.0243316010736758 0.113070270424368 GO:1901681 sulfur compound binding 43/2155 275/18639 0.156363636363636 1.35241847711453 0.0243930997022561 0.113070270424368 GO:0016279 protein-lysine N-methyltransferase activity 14/2155 69/18639 0.202898550724638 1.75490769696358 0.024794920273931 0.114502384635794 GO:0015605 organophosphate ester transmembrane transporter activity 11/2155 50/18639 0.22 1.90282134570766 0.0253391972640814 0.116579217263479 GO:0120015 sterol transfer activity 8/2155 32/18639 0.25 2.1622969837587 0.0260880699074664 0.119578402215264 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 6/2155 21/18639 0.285714285714286 2.47119655286709 0.0278051746608954 0.12558423068316 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 6/2155 21/18639 0.285714285714286 2.47119655286709 0.0278051746608954 0.12558423068316 GO:0010314 phosphatidylinositol-5-phosphate binding 6/2155 21/18639 0.285714285714286 2.47119655286709 0.0278051746608954 0.12558423068316 GO:0016278 lysine N-methyltransferase activity 14/2155 70/18639 0.2 1.72983758700696 0.0278057542388504 0.12558423068316 GO:0046982 protein heterodimerization activity 55/2155 369/18639 0.149051490514905 1.28917435346047 0.0289122559521556 0.129744774683727 GO:0003924 GTPase activity 50/2155 331/18639 0.151057401812689 1.30652385725601 0.028997564223306 0.129744774683727 GO:0005010 insulin-like growth factor receptor activity 11/2155 51/18639 0.215686274509804 1.8655111232428 0.0290426259632674 0.129744774683727 GO:0004527 exonuclease activity 16/2155 84/18639 0.19047619047619 1.64746436857806 0.0299128128299017 0.132142760751049 GO:0005159 insulin-like growth factor receptor binding 5/2155 16/18639 0.3125 2.70287122969838 0.0301146430642436 0.132142760751049 GO:0005114 type II transforming growth factor beta receptor binding 4/2155 11/18639 0.363636363636364 3.14515924910356 0.030131872073679 0.132142760751049 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4/2155 11/18639 0.363636363636364 3.14515924910356 0.030131872073679 0.132142760751049 GO:0046915 transition metal ion transmembrane transporter activity 10/2155 45/18639 0.222222222222222 1.92204176334107 0.0301575585724892 0.132142760751049 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 7/2155 27/18639 0.259259259259259 2.24238205723125 0.0302224318992666 0.132142760751049 GO:0000217 DNA secondary structure binding 9/2155 39/18639 0.230769230769231 1.99596644654649 0.0309074889768902 0.134359711510087 GO:0140311 protein sequestering activity 8/2155 33/18639 0.242424242424242 2.09677283273571 0.0310545112473891 0.134359711510087 GO:0008170 N-methyltransferase activity 18/2155 98/18639 0.183673469387755 1.58862635541456 0.0310563810059811 0.134359711510087 GO:0061980 regulatory RNA binding 12/2155 58/18639 0.206896551724138 1.78948715897272 0.0313946964336735 0.135348463995522 GO:0019199 transmembrane receptor protein kinase activity 15/2155 78/18639 0.192307692307692 1.66330537212208 0.0322016798704842 0.138343802370408 GO:0030021 extracellular matrix structural constituent conferring compression resistance 6/2155 22/18639 0.272727272727273 2.35886943682767 0.034599203758549 0.146434167066181 GO:0050321 tau-protein kinase activity 6/2155 22/18639 0.272727272727273 2.35886943682767 0.034599203758549 0.146434167066181 GO:0005518 collagen binding 14/2155 72/18639 0.194444444444444 1.68178654292343 0.0346196087127288 0.146434167066181 GO:0030276 clathrin binding 10/2155 46/18639 0.217391304347826 1.8802582467467 0.0346786510813665 0.146434167066181 GO:0030291 protein serine/threonine kinase inhibitor activity 10/2155 46/18639 0.217391304347826 1.8802582467467 0.0346786510813665 0.146434167066181 GO:1901981 phosphatidylinositol phosphate binding 30/2155 185/18639 0.162162162162162 1.40257101649213 0.0348934179147051 0.146838171634237 GO:0051213 dioxygenase activity 17/2155 93/18639 0.182795698924731 1.58103435371604 0.0368712463245336 0.154633492238605 GO:0004540 RNA nuclease activity 21/2155 121/18639 0.173553719008264 1.5010987325267 0.0370563127631752 0.154882825888119 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 41/2155 268/18639 0.152985074626866 1.32319666170309 0.0373499373015342 0.155582678016188 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 69/2155 484/18639 0.142561983471074 1.23304538743265 0.0382856939302731 0.158046457247772 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 5/2155 17/18639 0.294117647058824 2.543878804422 0.0387104866900464 0.158046457247772 GO:0008484 sulfuric ester hydrolase activity 5/2155 17/18639 0.294117647058824 2.543878804422 0.0387104866900464 0.158046457247772 GO:0038191 neuropilin binding 5/2155 17/18639 0.294117647058824 2.543878804422 0.0387104866900464 0.158046457247772 GO:0046965 nuclear retinoid X receptor binding 5/2155 17/18639 0.294117647058824 2.543878804422 0.0387104866900464 0.158046457247772 GO:0051787 misfolded protein binding 5/2155 17/18639 0.294117647058824 2.543878804422 0.0387104866900464 0.158046457247772 GO:0005095 GTPase inhibitor activity 4/2155 12/18639 0.333333333333333 2.8830626450116 0.0411547014845771 0.163689506227367 GO:0017166 vinculin binding 4/2155 12/18639 0.333333333333333 2.8830626450116 0.0411547014845771 0.163689506227367 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 4/2155 12/18639 0.333333333333333 2.8830626450116 0.0411547014845771 0.163689506227367 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 4/2155 12/18639 0.333333333333333 2.8830626450116 0.0411547014845771 0.163689506227367 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 4/2155 12/18639 0.333333333333333 2.8830626450116 0.0411547014845771 0.163689506227367 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 4/2155 12/18639 0.333333333333333 2.8830626450116 0.0411547014845771 0.163689506227367 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 4/2155 12/18639 0.333333333333333 2.8830626450116 0.0411547014845771 0.163689506227367 GO:1990247 N6-methyladenosine-containing RNA reader activity 4/2155 12/18639 0.333333333333333 2.8830626450116 0.0411547014845771 0.163689506227367 GO:0015175 neutral L-amino acid transmembrane transporter activity 9/2155 41/18639 0.219512195121951 1.89860222964179 0.0414800417577965 0.163925934254369 GO:0016877 ligase activity, forming carbon-sulfur bonds 9/2155 41/18639 0.219512195121951 1.89860222964179 0.0414800417577965 0.163925934254369 GO:0003887 DNA-directed DNA polymerase activity 6/2155 23/18639 0.260869565217391 2.25630989609604 0.0423765658974022 0.165545322767775 GO:0005158 insulin receptor binding 6/2155 23/18639 0.260869565217391 2.25630989609604 0.0423765658974022 0.165545322767775 GO:0015485 cholesterol binding 11/2155 54/18639 0.203703703703704 1.76187161639598 0.0424486998275712 0.165545322767775 GO:0017069 snRNA binding 11/2155 54/18639 0.203703703703704 1.76187161639598 0.0424486998275712 0.165545322767775 GO:0003684 damaged DNA binding 14/2155 74/18639 0.189189189189189 1.63633285257415 0.0425611251560297 0.165545322767775 GO:0001618 virus receptor activity 15/2155 81/18639 0.185185185185185 1.60170146945089 0.0433442902522623 0.168061351827168 GO:0061134 peptidase regulator activity 35/2155 226/18639 0.154867256637168 1.33947600763813 0.0440236752134653 0.170160475041388 GO:0019905 syntaxin binding 12/2155 61/18639 0.19672131147541 1.70147959377734 0.0445084295270835 0.171496542521544 GO:0032266 phosphatidylinositol-3-phosphate binding 10/2155 48/18639 0.208333333333333 1.80191415313225 0.0450915069963559 0.173201956780395 GO:0140223 general transcription initiation factor activity 13/2155 68/18639 0.191176470588235 1.6535212228743 0.0459794184186891 0.176064046305105 GO:0019208 phosphatase regulator activity 20/2155 117/18639 0.170940170940171 1.47849366410851 0.0471436392188658 0.179963180052203 GO:0035198 miRNA binding 9/2155 42/18639 0.214285714285714 1.85339741465031 0.0475818203358522 0.181075260722549 GO:0008525 phosphatidylcholine transporter activity 5/2155 18/18639 0.277777777777778 2.40255220417633 0.0486534099300181 0.182895287938147 GO:0034185 apolipoprotein binding 5/2155 18/18639 0.277777777777778 2.40255220417633 0.0486534099300181 0.182895287938147 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 5/2155 18/18639 0.277777777777778 2.40255220417633 0.0486534099300181 0.182895287938147 GO:0070628 proteasome binding 5/2155 18/18639 0.277777777777778 2.40255220417633 0.0486534099300181 0.182895287938147 GO:0001216 DNA-binding transcription activator activity 69/2155 491/18639 0.140529531568228 1.21546632895601 0.0495005763864566 0.184470897349089 GO:0005004 GPI-linked ephrin receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0005008 hepatocyte growth factor receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0005009 insulin receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0005011 macrophage colony-stimulating factor receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0005018 platelet-derived growth factor alpha-receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0005020 stem cell factor receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0008288 boss receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0036332 placental growth factor receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0038062 protein tyrosine kinase collagen receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0060175 brain-derived neurotrophic factor receptor activity 10/2155 49/18639 0.204081632653061 1.76514039490506 0.0510149216796216 0.184470897349089 GO:0001968 fibronectin binding 7/2155 30/18639 0.233333333333333 2.01814385150812 0.0511188315490095 0.184470897349089 GO:0004622 lysophospholipase activity 6/2155 24/18639 0.25 2.1622969837587 0.0511671102136159 0.184470897349089 GO:0050431 transforming growth factor beta binding 6/2155 24/18639 0.25 2.1622969837587 0.0511671102136159 0.184470897349089 GO:0030165 PDZ domain binding 15/2155 83/18639 0.180722891566265 1.56310625331954 0.0521418569454291 0.187437054267388 GO:0008035 high-density lipoprotein particle binding 4/2155 13/18639 0.307692307692308 2.66128859539532 0.0541546218420481 0.191875427388636 GO:0070123 transforming growth factor beta receptor activity, type III 4/2155 13/18639 0.307692307692308 2.66128859539532 0.0541546218420481 0.191875427388636 GO:0097157 pre-mRNA intronic binding 4/2155 13/18639 0.307692307692308 2.66128859539532 0.0541546218420481 0.191875427388636 GO:0140666 annealing activity 4/2155 13/18639 0.307692307692308 2.66128859539532 0.0541546218420481 0.191875427388636 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 4/2155 13/18639 0.307692307692308 2.66128859539532 0.0541546218420481 0.191875427388636 GO:0043022 ribosome binding 19/2155 112/18639 0.169642857142857 1.46727295326483 0.0554850224288938 0.19535650304594 GO:0019001 guanyl nucleotide binding 57/2155 400/18639 0.1425 1.23250928074246 0.0556124351736617 0.19535650304594 GO:0032561 guanyl ribonucleotide binding 57/2155 400/18639 0.1425 1.23250928074246 0.0556124351736617 0.19535650304594 GO:0051117 ATPase binding 15/2155 84/18639 0.178571428571429 1.54449784554193 0.056974257840109 0.198921181129392 GO:0005006 epidermal growth factor receptor activity 10/2155 50/18639 0.2 1.72983758700696 0.0574338527835066 0.198921181129392 GO:0005007 fibroblast growth factor receptor activity 10/2155 50/18639 0.2 1.72983758700696 0.0574338527835066 0.198921181129392 GO:0005017 platelet-derived growth factor receptor activity 10/2155 50/18639 0.2 1.72983758700696 0.0574338527835066 0.198921181129392 GO:0005019 platelet-derived growth factor beta-receptor activity 10/2155 50/18639 0.2 1.72983758700696 0.0574338527835066 0.198921181129392 GO:0001217 DNA-binding transcription repressor activity 41/2155 278/18639 0.147482014388489 1.27559965948355 0.0606807204911312 0.208887590102189 GO:0015297 antiporter activity 22/2155 135/18639 0.162962962962963 1.40949729311678 0.0607159193055513 0.208887590102189 GO:0047617 fatty acyl-CoA hydrolase activity 6/2155 25/18639 0.24 2.07580510440835 0.0609890774020989 0.208887590102189 GO:0120020 cholesterol transfer activity 6/2155 25/18639 0.24 2.07580510440835 0.0609890774020989 0.208887590102189 GO:0043014 alpha-tubulin binding 9/2155 44/18639 0.204545454545455 1.76915207762076 0.0614959347551787 0.210040131726137 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 21/2155 128/18639 0.1640625 1.41900739559165 0.0619621444045292 0.21104785649388 GO:0003743 translation initiation factor activity 10/2155 51/18639 0.196078431372549 1.695919202948 0.0643585422518577 0.217408445469974 GO:0005021 vascular endothelial growth factor receptor activity 10/2155 51/18639 0.196078431372549 1.695919202948 0.0643585422518577 0.217408445469974 GO:0005030 neurotrophin receptor activity 10/2155 51/18639 0.196078431372549 1.695919202948 0.0643585422518577 0.217408445469974 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 28/2155 181/18639 0.154696132596685 1.33799592365179 0.0665482215047476 0.224191139659436 GO:0120013 lipid transfer activity 12/2155 65/18639 0.184615384615385 1.59677315723719 0.067276206089666 0.226026054791712 GO:0016209 antioxidant activity 15/2155 86/18639 0.174418604651163 1.50857929099444 0.0675376114705778 0.226287703650061 GO:0005161 platelet-derived growth factor receptor binding 4/2155 14/18639 0.285714285714286 2.47119655286709 0.0691028551855536 0.228451272706491 GO:0005545 1-phosphatidylinositol binding 4/2155 14/18639 0.285714285714286 2.47119655286709 0.0691028551855536 0.228451272706491 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 4/2155 14/18639 0.285714285714286 2.47119655286709 0.0691028551855536 0.228451272706491 GO:0071813 lipoprotein particle binding 7/2155 32/18639 0.21875 1.89200986078886 0.0691097524083706 0.228451272706491 GO:0071814 protein-lipid complex binding 7/2155 32/18639 0.21875 1.89200986078886 0.0691097524083706 0.228451272706491 GO:0005080 protein kinase C binding 10/2155 52/18639 0.192307692307692 1.66330537212208 0.0717967718768756 0.234364904178123 GO:0016289 acyl-CoA hydrolase activity 6/2155 26/18639 0.230769230769231 1.99596644654649 0.0718490947115414 0.234364904178123 GO:0034237 protein kinase A regulatory subunit binding 6/2155 26/18639 0.230769230769231 1.99596644654649 0.0718490947115414 0.234364904178123 GO:0050681 nuclear androgen receptor binding 6/2155 26/18639 0.230769230769231 1.99596644654649 0.0718490947115414 0.234364904178123 GO:0052742 phosphatidylinositol kinase activity 6/2155 26/18639 0.230769230769231 1.99596644654649 0.0718490947115414 0.234364904178123 GO:0004721 phosphoprotein phosphatase activity 27/2155 175/18639 0.154285714285714 1.33444613854823 0.0723946602686984 0.235521414541702 GO:0036002 pre-mRNA binding 11/2155 59/18639 0.186440677966102 1.61256046246412 0.0732558423830741 0.237695930679817 GO:0005201 extracellular matrix structural constituent 26/2155 168/18639 0.154761904761905 1.33856479946967 0.0745030448120549 0.241108278879957 GO:0030296 protein tyrosine kinase activator activity 7/2155 33/18639 0.212121212121212 1.83467622864375 0.0793553942594041 0.251106034021452 GO:0071889 14-3-3 protein binding 7/2155 33/18639 0.212121212121212 1.83467622864375 0.0793553942594041 0.251106034021452 GO:0005003 ephrin receptor activity 10/2155 53/18639 0.188679245283019 1.63192225189336 0.0797537802357013 0.251106034021452 GO:0005005 transmembrane-ephrin receptor activity 10/2155 53/18639 0.188679245283019 1.63192225189336 0.0797537802357013 0.251106034021452 GO:0038064 collagen receptor activity 10/2155 53/18639 0.188679245283019 1.63192225189336 0.0797537802357013 0.251106034021452 GO:0033192 calmodulin-dependent protein phosphatase activity 14/2155 81/18639 0.172839506172839 1.4949213714875 0.0802398843507315 0.251106034021452 GO:0140791 histone H2AXS140 phosphatase activity 14/2155 81/18639 0.172839506172839 1.4949213714875 0.0802398843507315 0.251106034021452 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 14/2155 81/18639 0.172839506172839 1.4949213714875 0.0802398843507315 0.251106034021452 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 14/2155 81/18639 0.172839506172839 1.4949213714875 0.0802398843507315 0.251106034021452 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 14/2155 81/18639 0.172839506172839 1.4949213714875 0.0802398843507315 0.251106034021452 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 14/2155 81/18639 0.172839506172839 1.4949213714875 0.0802398843507315 0.251106034021452 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 14/2155 81/18639 0.172839506172839 1.4949213714875 0.0802398843507315 0.251106034021452 GO:1990439 MAP kinase serine/threonine phosphatase activity 14/2155 81/18639 0.172839506172839 1.4949213714875 0.0802398843507315 0.251106034021452 GO:0004714 transmembrane receptor protein tyrosine kinase activity 11/2155 60/18639 0.183333333333333 1.58568445475638 0.0807713176782408 0.252129201765243 GO:0008266 poly(U) RNA binding 6/2155 27/18639 0.222222222222222 1.92204176334107 0.0837424269436199 0.260743465710816 GO:0005319 lipid transporter activity 27/2155 178/18639 0.151685393258427 1.3119554732918 0.0851741713883242 0.262909501890366 GO:0042809 nuclear vitamin D receptor binding 4/2155 15/18639 0.266666666666667 2.30645011600928 0.0859306806665187 0.262909501890366 GO:0050700 CARD domain binding 4/2155 15/18639 0.266666666666667 2.30645011600928 0.0859306806665187 0.262909501890366 GO:0051371 muscle alpha-actinin binding 4/2155 15/18639 0.266666666666667 2.30645011600928 0.0859306806665187 0.262909501890366 GO:0120283 protein serine/threonine kinase binding 4/2155 15/18639 0.266666666666667 2.30645011600928 0.0859306806665187 0.262909501890366 GO:0141050 histone H3K deacetylase activity 4/2155 15/18639 0.266666666666667 2.30645011600928 0.0859306806665187 0.262909501890366 GO:0141051 histone H4K deacetylase activity 4/2155 15/18639 0.266666666666667 2.30645011600928 0.0859306806665187 0.262909501890366 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 14/2155 82/18639 0.170731707317073 1.47669062305472 0.08695968297603 0.264743923727025 GO:0033549 MAP kinase phosphatase activity 14/2155 82/18639 0.170731707317073 1.47669062305472 0.08695968297603 0.264743923727025 GO:0030332 cyclin binding 7/2155 34/18639 0.205882352941176 1.7807151630954 0.0904321706244202 0.273962816658256 GO:0052866 phosphatidylinositol phosphate phosphatase activity 7/2155 34/18639 0.205882352941176 1.7807151630954 0.0904321706244202 0.273962816658256 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 14/2155 83/18639 0.168674698795181 1.45889916976491 0.0940241694170218 0.284146570811735 GO:0042169 SH2 domain binding 8/2155 41/18639 0.195121951219512 1.68764642634825 0.094335597414379 0.284390688537724 GO:0017022 myosin binding 13/2155 76/18639 0.171052631578947 1.47946635730858 0.0954370471503081 0.286625494987069 GO:0016791 phosphatase activity 39/2155 273/18639 0.142857142857143 1.23559827643354 0.0955418316623562 0.286625494987069 GO:0046875 ephrin receptor binding 6/2155 28/18639 0.214285714285714 1.85339741465031 0.0966534473764079 0.287859180229736 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 6/2155 28/18639 0.214285714285714 1.85339741465031 0.0966534473764079 0.287859180229736 GO:0097718 disordered domain specific binding 6/2155 28/18639 0.214285714285714 1.85339741465031 0.0966534473764079 0.287859180229736 GO:0015179 L-amino acid transmembrane transporter activity 11/2155 62/18639 0.17741935483871 1.53453334331263 0.0971900588846303 0.288190241533339 GO:0008374 O-acyltransferase activity 10/2155 55/18639 0.181818181818182 1.57257962455178 0.0972320685140867 0.288190241533339 GO:0000182 rDNA binding 3/2155 10/18639 0.3 2.59475638051044 0.0995246622954467 0.28873860849479 GO:0001094 TFIID-class transcription factor complex binding 3/2155 10/18639 0.3 2.59475638051044 0.0995246622954467 0.28873860849479 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/2155 10/18639 0.3 2.59475638051044 0.0995246622954467 0.28873860849479 GO:0005131 growth hormone receptor binding 3/2155 10/18639 0.3 2.59475638051044 0.0995246622954467 0.28873860849479 GO:0008641 ubiquitin-like modifier activating enzyme activity 3/2155 10/18639 0.3 2.59475638051044 0.0995246622954467 0.28873860849479 GO:0015643 toxic substance binding 3/2155 10/18639 0.3 2.59475638051044 0.0995246622954467 0.28873860849479 GO:0045322 unmethylated CpG binding 3/2155 10/18639 0.3 2.59475638051044 0.0995246622954467 0.28873860849479 GO:0050815 phosphoserine residue binding 3/2155 10/18639 0.3 2.59475638051044 0.0995246622954467 0.28873860849479 GO:0051880 G-quadruplex DNA binding 3/2155 10/18639 0.3 2.59475638051044 0.0995246622954467 0.28873860849479 GO:0017018 myosin phosphatase activity 14/2155 84/18639 0.166666666666667 1.4415313225058 0.101434151732404 0.292999672913265 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 5/2155 22/18639 0.227272727272727 1.96572453068973 0.10194392512554 0.292999672913265 GO:0140035 ubiquitin-like protein reader activity 5/2155 22/18639 0.227272727272727 1.96572453068973 0.10194392512554 0.292999672913265 GO:0140517 protein-RNA adaptor activity 5/2155 22/18639 0.227272727272727 1.96572453068973 0.10194392512554 0.292999672913265 GO:0016779 nucleotidyltransferase activity 21/2155 136/18639 0.154411764705882 1.33553637232155 0.102429171629043 0.293028233453853 GO:0140789 histone phosphatase activity 21/2155 136/18639 0.154411764705882 1.33553637232155 0.102429171629043 0.293028233453853 GO:0005024 transforming growth factor beta receptor activity 4/2155 16/18639 0.25 2.1622969837587 0.104536026533944 0.296305564865178 GO:0022858 alanine transmembrane transporter activity 4/2155 16/18639 0.25 2.1622969837587 0.104536026533944 0.296305564865178 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 4/2155 16/18639 0.25 2.1622969837587 0.104536026533944 0.296305564865178 GO:0140328 floppase activity 4/2155 16/18639 0.25 2.1622969837587 0.104536026533944 0.296305564865178 GO:0008307 structural constituent of muscle 8/2155 42/18639 0.19047619047619 1.64746436857806 0.105336486138738 0.297207980341108 GO:0048487 beta-tubulin binding 8/2155 42/18639 0.19047619047619 1.64746436857806 0.105336486138738 0.297207980341108 GO:0060590 ATPase regulator activity 9/2155 49/18639 0.183673469387755 1.58862635541456 0.106619734923435 0.300141856531039 GO:0019888 protein phosphatase regulator activity 17/2155 107/18639 0.158878504672897 1.37417004575319 0.108359567261908 0.304344752696885 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 6/2155 29/18639 0.206896551724138 1.78948715897272 0.11055629144994 0.308407030221212 GO:0016417 S-acyltransferase activity 6/2155 29/18639 0.206896551724138 1.78948715897272 0.11055629144994 0.308407030221212 GO:0097472 cyclin-dependent protein kinase activity 6/2155 29/18639 0.206896551724138 1.78948715897272 0.11055629144994 0.308407030221212 GO:0004712 protein serine/threonine/tyrosine kinase activity 8/2155 43/18639 0.186046511627907 1.60915124372741 0.117013506272031 0.325683190143148 GO:0000295 adenine nucleotide transmembrane transporter activity 5/2155 23/18639 0.217391304347826 1.8802582467467 0.118490413800023 0.327575516178089 GO:0004602 glutathione peroxidase activity 5/2155 23/18639 0.217391304347826 1.8802582467467 0.118490413800023 0.327575516178089 GO:0017134 fibroblast growth factor binding 5/2155 23/18639 0.217391304347826 1.8802582467467 0.118490413800023 0.327575516178089 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/2155 17/18639 0.235294117647059 2.0351030435376 0.124790038793605 0.332187553624626 GO:0005092 GDP-dissociation inhibitor activity 4/2155 17/18639 0.235294117647059 2.0351030435376 0.124790038793605 0.332187553624626 GO:0030169 low-density lipoprotein particle binding 4/2155 17/18639 0.235294117647059 2.0351030435376 0.124790038793605 0.332187553624626 GO:0048038 quinone binding 4/2155 17/18639 0.235294117647059 2.0351030435376 0.124790038793605 0.332187553624626 GO:0160215 deacylase activity 11/2155 65/18639 0.169230769230769 1.46370872746743 0.125267611892982 0.332187553624626 GO:0015215 nucleotide transmembrane transporter activity 6/2155 30/18639 0.2 1.72983758700696 0.125415656425173 0.332187553624626 GO:0031210 phosphatidylcholine binding 6/2155 30/18639 0.2 1.72983758700696 0.125415656425173 0.332187553624626 GO:0031624 ubiquitin conjugating enzyme binding 6/2155 30/18639 0.2 1.72983758700696 0.125415656425173 0.332187553624626 GO:0035925 mRNA 3'-UTR AU-rich region binding 6/2155 30/18639 0.2 1.72983758700696 0.125415656425173 0.332187553624626 GO:0008526 phosphatidylinositol transfer activity 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0015173 aromatic amino acid transmembrane transporter activity 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0032050 clathrin heavy chain binding 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0034056 estrogen response element binding 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0034713 type I transforming growth factor beta receptor binding 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0045294 alpha-catenin binding 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0048185 activin binding 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0097493 structural molecule activity conferring elasticity 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0140537 transcription regulator activator activity 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/2155 11/18639 0.272727272727273 2.35886943682767 0.12554695862861 0.332187553624626 GO:0042277 peptide binding 35/2155 249/18639 0.140562248995984 1.21574930813742 0.12846613743537 0.338578717165946 GO:0005048 signal sequence binding 9/2155 51/18639 0.176470588235294 1.5263272826532 0.128786227372935 0.338578717165946 GO:0016597 amino acid binding 9/2155 51/18639 0.176470588235294 1.5263272826532 0.128786227372935 0.338578717165946 GO:0016790 thiolester hydrolase activity 8/2155 44/18639 0.181818181818182 1.57257962455178 0.129350744386887 0.339339293253259 GO:0004867 serine-type endopeptidase inhibitor activity 15/2155 95/18639 0.157894736842105 1.36566125290023 0.130570449944273 0.341811814822269 GO:0004722 protein serine/threonine phosphatase activity 16/2155 103/18639 0.155339805825243 1.34356317437434 0.134778564508537 0.352080444997936 GO:0060229 lipase activator activity 5/2155 24/18639 0.208333333333333 1.80191415313225 0.13620707263855 0.355059874341084 GO:0045309 protein phosphorylated amino acid binding 10/2155 59/18639 0.169491525423729 1.46596405678556 0.138354924426989 0.358656169743978 GO:0015101 organic cation transmembrane transporter activity 13/2155 81/18639 0.160493827160494 1.3881412735241 0.138459316137983 0.358656169743978 GO:0030971 receptor tyrosine kinase binding 13/2155 81/18639 0.160493827160494 1.3881412735241 0.138459316137983 0.358656169743978 GO:0051087 protein-folding chaperone binding 20/2155 134/18639 0.149253731343284 1.29092357239325 0.139460101763284 0.360491206444716 GO:0016411 acylglycerol O-acyltransferase activity 6/2155 31/18639 0.193548387096774 1.67403637452287 0.141187711720502 0.362675934482041 GO:0016878 acid-thiol ligase activity 6/2155 31/18639 0.193548387096774 1.67403637452287 0.141187711720502 0.362675934482041 GO:0047499 calcium-independent phospholipase A2 activity 6/2155 31/18639 0.193548387096774 1.67403637452287 0.141187711720502 0.362675934482041 GO:0004715 non-membrane spanning protein tyrosine kinase activity 8/2155 45/18639 0.177777777777778 1.53763341067285 0.142328088297382 0.364845182683309 GO:0043531 ADP binding 7/2155 38/18639 0.184210526315789 1.59327146171694 0.142745182795758 0.365155208272136 GO:0042826 histone deacetylase binding 19/2155 127/18639 0.149606299212598 1.29397299815481 0.144454060419304 0.368761607654248 GO:0016500 protein-hormone receptor activity 11/2155 67/18639 0.164179104477612 1.42001592963258 0.146222838935274 0.370262222366863 GO:0000400 four-way junction DNA binding 4/2155 18/18639 0.222222222222222 1.92204176334107 0.146543361326058 0.370262222366863 GO:0003746 translation elongation factor activity 4/2155 18/18639 0.222222222222222 1.92204176334107 0.146543361326058 0.370262222366863 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4/2155 18/18639 0.222222222222222 1.92204176334107 0.146543361326058 0.370262222366863 GO:0017075 syntaxin-1 binding 4/2155 18/18639 0.222222222222222 1.92204176334107 0.146543361326058 0.370262222366863 GO:0000340 RNA 7-methylguanosine cap binding 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0004859 phospholipase inhibitor activity 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0005025 transforming growth factor beta receptor activity, type I 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0005026 transforming growth factor beta receptor activity, type II 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0016208 AMP binding 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0016273 arginine N-methyltransferase activity 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0016274 protein-arginine N-methyltransferase activity 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0016361 activin receptor activity, type I 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0016362 activin receptor activity, type II 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0017002 activin receptor activity 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0035197 siRNA binding 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0035497 cAMP response element binding 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0043047 single-stranded telomeric DNA binding 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0070008 serine-type exopeptidase activity 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:1990817 poly(A) RNA polymerase activity 3/2155 12/18639 0.25 2.1622969837587 0.153677711009954 0.375217064703511 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 24/2155 167/18639 0.143712574850299 1.242997068508 0.15402800021327 0.375329099333918 GO:0003707 nuclear steroid receptor activity 5/2155 25/18639 0.2 1.72983758700696 0.155011571447663 0.376238715738128 GO:0004709 MAP kinase kinase kinase activity 5/2155 25/18639 0.2 1.72983758700696 0.155011571447663 0.376238715738128 GO:0019955 cytokine binding 21/2155 144/18639 0.145833333333333 1.26133990719258 0.156567773334205 0.379269281966748 GO:0030145 manganese ion binding 11/2155 68/18639 0.161764705882353 1.3991333424321 0.157343656092972 0.380065234775167 GO:0043425 bHLH transcription factor binding 6/2155 32/18639 0.1875 1.62172273781903 0.157821086946379 0.380065234775167 GO:0047498 calcium-dependent phospholipase A2 activity 6/2155 32/18639 0.1875 1.62172273781903 0.157821086946379 0.380065234775167 GO:0098631 cell adhesion mediator activity 12/2155 76/18639 0.157894736842105 1.36566125290023 0.163500765099238 0.392975523133257 GO:0005178 integrin binding 23/2155 161/18639 0.142857142857143 1.23559827643354 0.167186215540547 0.401051758290845 GO:0005346 purine ribonucleotide transmembrane transporter activity 4/2155 19/18639 0.210526315789474 1.82088167053364 0.169631953052142 0.404118353345228 GO:0042577 lipid phosphatase activity 4/2155 19/18639 0.210526315789474 1.82088167053364 0.169631953052142 0.404118353345228 GO:0140036 ubiquitin-modified protein reader activity 4/2155 19/18639 0.210526315789474 1.82088167053364 0.169631953052142 0.404118353345228 GO:0061749 forked DNA-dependent helicase activity 8/2155 47/18639 0.170212765957447 1.47220220170805 0.170103345811982 0.404118353345228 GO:1990518 single-stranded 3'-5' DNA helicase activity 8/2155 47/18639 0.170212765957447 1.47220220170805 0.170103345811982 0.404118353345228 GO:0004518 nuclease activity 29/2155 209/18639 0.138755980861244 1.20012655557899 0.171799706135761 0.407363533971911 GO:0017124 SH3 domain binding 17/2155 115/18639 0.147826086956522 1.27857560778775 0.172780965787781 0.408616784980277 GO:0030331 nuclear estrogen receptor binding 7/2155 40/18639 0.175 1.51360788863109 0.17332244813032 0.408616784980277 GO:0071949 FAD binding 7/2155 40/18639 0.175 1.51360788863109 0.17332244813032 0.408616784980277 GO:0005112 Notch binding 5/2155 26/18639 0.192307692307692 1.66330537212208 0.17481216114674 0.410558847036058 GO:0015216 purine nucleotide transmembrane transporter activity 5/2155 26/18639 0.192307692307692 1.66330537212208 0.17481216114674 0.410558847036058 GO:0070851 growth factor receptor binding 20/2155 139/18639 0.143884892086331 1.24448747266688 0.178871286305099 0.419293338430014 GO:0140313 molecular sequestering activity 9/2155 55/18639 0.163636363636364 1.4153216620966 0.179662264683858 0.420348334639842 GO:0005338 nucleotide-sugar transmembrane transporter activity 3/2155 13/18639 0.230769230769231 1.99596644654649 0.183534637760326 0.423779416401651 GO:0017154 semaphorin receptor activity 3/2155 13/18639 0.230769230769231 1.99596644654649 0.183534637760326 0.423779416401651 GO:0019855 calcium channel inhibitor activity 3/2155 13/18639 0.230769230769231 1.99596644654649 0.183534637760326 0.423779416401651 GO:0046974 histone H3K9 methyltransferase activity 3/2155 13/18639 0.230769230769231 1.99596644654649 0.183534637760326 0.423779416401651 GO:0046975 histone H3K36 methyltransferase activity 3/2155 13/18639 0.230769230769231 1.99596644654649 0.183534637760326 0.423779416401651 GO:0089720 caspase binding 3/2155 13/18639 0.230769230769231 1.99596644654649 0.183534637760326 0.423779416401651 GO:0140333 glycerophospholipid flippase activity 3/2155 13/18639 0.230769230769231 1.99596644654649 0.183534637760326 0.423779416401651 GO:0009378 four-way junction helicase activity 8/2155 48/18639 0.166666666666667 1.4415313225058 0.184842693782321 0.424415347176166 GO:0036121 double-stranded DNA helicase activity 8/2155 48/18639 0.166666666666667 1.4415313225058 0.184842693782321 0.424415347176166 GO:0043138 3'-5' DNA helicase activity 8/2155 48/18639 0.166666666666667 1.4415313225058 0.184842693782321 0.424415347176166 GO:0001727 lipid kinase activity 7/2155 41/18639 0.170731707317073 1.47669062305472 0.189584446807132 0.434493722886976 GO:1990782 protein tyrosine kinase binding 17/2155 117/18639 0.145299145299145 1.25671961449224 0.19145135318317 0.437958290305843 GO:0016004 phospholipase activator activity 4/2155 20/18639 0.2 1.72983758700696 0.193882336798115 0.439095843238012 GO:0042288 MHC class I protein binding 4/2155 20/18639 0.2 1.72983758700696 0.193882336798115 0.439095843238012 GO:0052745 inositol phosphate phosphatase activity 4/2155 20/18639 0.2 1.72983758700696 0.193882336798115 0.439095843238012 GO:0061608 nuclear import signal receptor activity 4/2155 20/18639 0.2 1.72983758700696 0.193882336798115 0.439095843238012 GO:0042562 hormone binding 14/2155 94/18639 0.148936170212766 1.28817692649455 0.193922076089557 0.439095843238012 GO:0001671 ATPase activator activity 5/2155 27/18639 0.185185185185185 1.60170146945089 0.195509828011086 0.439095843238012 GO:0004683 calcium/calmodulin-dependent protein kinase activity 5/2155 27/18639 0.185185185185185 1.60170146945089 0.195509828011086 0.439095843238012 GO:0005385 zinc ion transmembrane transporter activity 5/2155 27/18639 0.185185185185185 1.60170146945089 0.195509828011086 0.439095843238012 GO:0016405 CoA-ligase activity 5/2155 27/18639 0.185185185185185 1.60170146945089 0.195509828011086 0.439095843238012 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 5/2155 27/18639 0.185185185185185 1.60170146945089 0.195509828011086 0.439095843238012 GO:0019894 kinesin binding 7/2155 42/18639 0.166666666666667 1.4415313225058 0.20643403894081 0.461947676976441 GO:0031492 nucleosomal DNA binding 7/2155 42/18639 0.166666666666667 1.4415313225058 0.20643403894081 0.461947676976441 GO:0015631 tubulin binding 50/2155 385/18639 0.12987012987013 1.12327116039413 0.208860946316135 0.46653178769528 GO:1902936 phosphatidylinositol bisphosphate binding 16/2155 111/18639 0.144144144144144 1.24672979243745 0.209427503008567 0.466951376509155 GO:0004623 phospholipase A2 activity 6/2155 35/18639 0.171428571428571 1.48271793172025 0.212284201392334 0.468634506144389 GO:0005154 epidermal growth factor receptor binding 6/2155 35/18639 0.171428571428571 1.48271793172025 0.212284201392334 0.468634506144389 GO:0034061 DNA polymerase activity 6/2155 35/18639 0.171428571428571 1.48271793172025 0.212284201392334 0.468634506144389 GO:0005347 ATP transmembrane transporter activity 3/2155 14/18639 0.214285714285714 1.85339741465031 0.214743305735263 0.468634506144389 GO:0008195 phosphatidate phosphatase activity 3/2155 14/18639 0.214285714285714 1.85339741465031 0.214743305735263 0.468634506144389 GO:0008494 translation activator activity 3/2155 14/18639 0.214285714285714 1.85339741465031 0.214743305735263 0.468634506144389 GO:0034236 protein kinase A catalytic subunit binding 3/2155 14/18639 0.214285714285714 1.85339741465031 0.214743305735263 0.468634506144389 GO:0044548 S100 protein binding 3/2155 14/18639 0.214285714285714 1.85339741465031 0.214743305735263 0.468634506144389 GO:0046030 inositol trisphosphate phosphatase activity 3/2155 14/18639 0.214285714285714 1.85339741465031 0.214743305735263 0.468634506144389 GO:0070742 C2H2 zinc finger domain binding 3/2155 14/18639 0.214285714285714 1.85339741465031 0.214743305735263 0.468634506144389 GO:0071933 Arp2/3 complex binding 3/2155 14/18639 0.214285714285714 1.85339741465031 0.214743305735263 0.468634506144389 GO:0098821 BMP receptor activity 3/2155 14/18639 0.214285714285714 1.85339741465031 0.214743305735263 0.468634506144389 GO:0004896 cytokine receptor activity 14/2155 96/18639 0.145833333333333 1.26133990719258 0.216092709914346 0.470746133081959 GO:0046966 nuclear thyroid hormone receptor binding 5/2155 28/18639 0.178571428571429 1.54449784554193 0.217000345540363 0.47105884868181 GO:0051393 alpha-actinin binding 5/2155 28/18639 0.178571428571429 1.54449784554193 0.217000345540363 0.47105884868181 GO:0008373 sialyltransferase activity 4/2155 21/18639 0.19047619047619 1.64746436857806 0.219116226248721 0.473982994674865 GO:0072542 protein phosphatase activator activity 4/2155 21/18639 0.19047619047619 1.64746436857806 0.219116226248721 0.473982994674865 GO:0005200 structural constituent of cytoskeleton 16/2155 112/18639 0.142857142857143 1.23559827643354 0.21989192285724 0.474827917483323 GO:0051082 unfolded protein binding 17/2155 121/18639 0.140495867768595 1.21517516442638 0.231529926786584 0.498473629783985 GO:0055106 ubiquitin-protein transferase regulator activity 6/2155 36/18639 0.166666666666667 1.4415313225058 0.231734878715086 0.498473629783985 GO:0016830 carbon-carbon lyase activity 8/2155 51/18639 0.156862745098039 1.3567353623584 0.232055039331717 0.498473629783985 GO:0015459 potassium channel regulator activity 9/2155 59/18639 0.152542372881356 1.319367651107 0.238066332944392 0.509333752065191 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 9/2155 59/18639 0.152542372881356 1.319367651107 0.238066332944392 0.509333752065191 GO:0003785 actin monomer binding 5/2155 29/18639 0.172413793103448 1.49123929914393 0.239176190142535 0.509333752065191 GO:0043236 laminin binding 5/2155 29/18639 0.172413793103448 1.49123929914393 0.239176190142535 0.509333752065191 GO:0106222 lncRNA binding 5/2155 29/18639 0.172413793103448 1.49123929914393 0.239176190142535 0.509333752065191 GO:0004407 histone deacetylase activity 4/2155 22/18639 0.181818181818182 1.57257962455178 0.245154515387206 0.519373741361554 GO:0033558 protein lysine deacetylase activity 4/2155 22/18639 0.181818181818182 1.57257962455178 0.245154515387206 0.519373741361554 GO:0061133 endopeptidase activator activity 4/2155 22/18639 0.181818181818182 1.57257962455178 0.245154515387206 0.519373741361554 GO:0010181 FMN binding 3/2155 15/18639 0.2 1.72983758700696 0.24694646200245 0.521378403508597 GO:0047372 monoacylglycerol lipase activity 3/2155 15/18639 0.2 1.72983758700696 0.24694646200245 0.521378403508597 GO:0001540 amyloid-beta binding 12/2155 83/18639 0.144578313253012 1.25048500265563 0.248240553537499 0.523214705148268 GO:0042805 actinin binding 6/2155 37/18639 0.162162162162162 1.40257101649213 0.251713432309578 0.529629116105306 GO:0031072 heat shock protein binding 18/2155 131/18639 0.137404580152672 1.18843803687501 0.252798037399234 0.531005076853927 GO:0008168 methyltransferase activity 27/2155 204/18639 0.132352941176471 1.1447454619899 0.25534541661321 0.535443705245048 GO:0140303 intramembrane lipid transporter activity 7/2155 45/18639 0.155555555555556 1.34542923433875 0.259998465739255 0.544275226241938 GO:0001965 G-protein alpha-subunit binding 5/2155 30/18639 0.166666666666667 1.4415313225058 0.261928296886007 0.546459543249487 GO:0070566 adenylyltransferase activity 5/2155 30/18639 0.166666666666667 1.4415313225058 0.261928296886007 0.546459543249487 GO:0043178 alcohol binding 13/2155 92/18639 0.141304347826087 1.22216786038535 0.262701404197588 0.547146674620991 GO:1901505 carbohydrate derivative transmembrane transporter activity 8/2155 53/18639 0.150943396226415 1.30553780151469 0.265636502060844 0.552326824689748 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 4/2155 23/18639 0.173913043478261 1.50420659739736 0.271820642037139 0.562068273403997 GO:0043274 phospholipase binding 4/2155 23/18639 0.173913043478261 1.50420659739736 0.271820642037139 0.562068273403997 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 4/2155 23/18639 0.173913043478261 1.50420659739736 0.271820642037139 0.562068273403997 GO:0042887 amide transmembrane transporter activity 6/2155 38/18639 0.157894736842105 1.36566125290023 0.272144979093419 0.562068273403997 GO:0016741 transferase activity, transferring one-carbon groups 28/2155 215/18639 0.130232558139535 1.12640587060918 0.279301976713848 0.567444463592519 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0004707 MAP kinase activity 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0004708 MAP kinase kinase activity 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0008142 oxysterol binding 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0008296 3'-5'-DNA exonuclease activity 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0015562 efflux transmembrane transporter activity 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0016722 oxidoreductase activity, acting on metal ions 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0017070 U6 snRNA binding 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0043023 ribosomal large subunit binding 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0140327 flippase activity 3/2155 16/18639 0.1875 1.62172273781903 0.279810408649028 0.567444463592519 GO:0005516 calmodulin binding 27/2155 207/18639 0.130434782608696 1.12815494804802 0.281037100678531 0.568996297432887 GO:0008327 methyl-CpG binding 5/2155 31/18639 0.161290322580645 1.39503031210239 0.285147640187066 0.575428871277663 GO:0070273 phosphatidylinositol-4-phosphate binding 5/2155 31/18639 0.161290322580645 1.39503031210239 0.285147640187066 0.575428871277663 GO:0061135 endopeptidase regulator activity 24/2155 184/18639 0.130434782608696 1.12815494804802 0.295626085021217 0.595599612469217 GO:0005315 phosphate transmembrane transporter activity 4/2155 24/18639 0.166666666666667 1.4415313225058 0.298943355916857 0.599344972106479 GO:0050699 WW domain binding 4/2155 24/18639 0.166666666666667 1.4415313225058 0.298943355916857 0.599344972106479 GO:0070840 dynein complex binding 4/2155 24/18639 0.166666666666667 1.4415313225058 0.298943355916857 0.599344972106479 GO:0140299 molecular sensor activity 10/2155 71/18639 0.140845070422535 1.21819548380772 0.302842810402283 0.606177248743531 GO:0046906 tetrapyrrole binding 20/2155 152/18639 0.131578947368421 1.13805104408353 0.30336241231457 0.606233151351483 GO:0044325 transmembrane transporter binding 18/2155 136/18639 0.132352941176471 1.1447454619899 0.307128741032544 0.612766565846484 GO:0008429 phosphatidylethanolamine binding 3/2155 17/18639 0.176470588235294 1.5263272826532 0.313029059332333 0.616850722597574 GO:0009881 photoreceptor activity 3/2155 17/18639 0.176470588235294 1.5263272826532 0.313029059332333 0.616850722597574 GO:0015278 intracellularly gated calcium channel activity 3/2155 17/18639 0.176470588235294 1.5263272826532 0.313029059332333 0.616850722597574 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/2155 17/18639 0.176470588235294 1.5263272826532 0.313029059332333 0.616850722597574 GO:0045125 bioactive lipid receptor activity 3/2155 17/18639 0.176470588235294 1.5263272826532 0.313029059332333 0.616850722597574 GO:0070402 NADPH binding 3/2155 17/18639 0.176470588235294 1.5263272826532 0.313029059332333 0.616850722597574 GO:0004177 aminopeptidase activity 6/2155 40/18639 0.15 1.29737819025522 0.314065544170346 0.616850722597574 GO:0050997 quaternary ammonium group binding 6/2155 40/18639 0.15 1.29737819025522 0.314065544170346 0.616850722597574 GO:0003680 minor groove of adenine-thymine-rich DNA binding 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0004445 inositol-polyphosphate 5-phosphatase activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0004955 prostaglandin receptor activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0005381 iron ion transmembrane transporter activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0015187 glycine transmembrane transporter activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0016303 1-phosphatidylinositol-3-kinase activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0016868 intramolecular phosphotransferase activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0030957 Tat protein binding 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0031419 cobalamin binding 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0031720 haptoglobin binding 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0043121 neurotrophin binding 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0043422 protein kinase B binding 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0098505 G-rich strand telomeric DNA binding 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0140940 histone H2A methyltransferase activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0140999 histone H3K4 trimethyltransferase activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:1990259 histone H2AQ104 methyltransferase activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:1990757 ubiquitin ligase activator activity 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:1990763 arrestin family protein binding 2/2155 10/18639 0.2 1.72983758700696 0.3246846058117 0.616850722597574 GO:0008483 transaminase activity 4/2155 25/18639 0.16 1.38387006960557 0.326358933910989 0.617178781460505 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/2155 25/18639 0.16 1.38387006960557 0.326358933910989 0.617178781460505 GO:0019707 protein-cysteine S-acyltransferase activity 4/2155 25/18639 0.16 1.38387006960557 0.326358933910989 0.617178781460505 GO:0042578 phosphoric ester hydrolase activity 45/2155 363/18639 0.12396694214876 1.07221338037622 0.33134568404194 0.625649660679497 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 6/2155 41/18639 0.146341463414634 1.26573481976119 0.335405160861182 0.63070317314138 GO:0140828 metal cation:monoatomic cation antiporter activity 6/2155 41/18639 0.146341463414634 1.26573481976119 0.335405160861182 0.63070317314138 GO:0038024 cargo receptor activity 9/2155 65/18639 0.138461538461538 1.1975798679279 0.335556594955998 0.63070317314138 GO:0004601 peroxidase activity 8/2155 57/18639 0.140350877192982 1.2139211136891 0.336334830277397 0.631203722575389 GO:0004725 protein tyrosine phosphatase activity 13/2155 98/18639 0.13265306122449 1.14734125668829 0.342807572494592 0.642373460312815 GO:0015172 acidic amino acid transmembrane transporter activity 3/2155 18/18639 0.166666666666667 1.4415313225058 0.346326198933588 0.645045624297756 GO:0015280 ligand-gated sodium channel activity 3/2155 18/18639 0.166666666666667 1.4415313225058 0.346326198933588 0.645045624297756 GO:0030228 lipoprotein particle receptor activity 3/2155 18/18639 0.166666666666667 1.4415313225058 0.346326198933588 0.645045624297756 GO:0050811 GABA receptor binding 3/2155 18/18639 0.166666666666667 1.4415313225058 0.346326198933588 0.645045624297756 GO:0003678 DNA helicase activity 10/2155 74/18639 0.135135135135135 1.16880918041011 0.350280599675424 0.651426816590946 GO:0008157 protein phosphatase 1 binding 4/2155 26/18639 0.153846153846154 1.33064429769766 0.353912892595398 0.656202400857332 GO:0070006 metalloaminopeptidase activity 4/2155 26/18639 0.153846153846154 1.33064429769766 0.353912892595398 0.656202400857332 GO:0017116 single-stranded DNA helicase activity 8/2155 58/18639 0.137931034482759 1.19299143931515 0.354491424228052 0.656288177287069 GO:0019825 oxygen binding 5/2155 34/18639 0.147058823529412 1.271939402211 0.35654748414814 0.658321033710554 GO:0051879 Hsp90 protein binding 6/2155 42/18639 0.142857142857143 1.23559827643354 0.356900347847912 0.658321033710554 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0002162 dystroglycan binding 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0003953 NAD+ nucleosidase activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0004954 prostanoid receptor activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0005225 volume-sensitive anion channel activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0005536 D-glucose binding 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0008172 S-methyltransferase activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0010854 adenylate cyclase regulator activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0016176 superoxide-generating NADPH oxidase activator activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0019107 myristoyltransferase activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0019215 intermediate filament binding 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0047676 arachidonate-CoA ligase activity 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0048407 platelet-derived growth factor binding 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0050786 RAGE receptor binding 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0050998 nitric-oxide synthase binding 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0070697 activin receptor binding 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0140031 phosphorylation-dependent protein binding 2/2155 11/18639 0.181818181818182 1.57257962455178 0.368937416296831 0.658321033710554 GO:0070888 E-box binding 8/2155 59/18639 0.135593220338983 1.17277124542845 0.372754183645097 0.664170387910989 GO:0005272 sodium channel activity 7/2155 51/18639 0.137254901960784 1.1871434420636 0.375769491457529 0.668364750543936 GO:0020037 heme binding 18/2155 142/18639 0.126760563380282 1.09637593542695 0.376192325123675 0.668364750543936 GO:0042834 peptidoglycan binding 3/2155 19/18639 0.157894736842105 1.36566125290023 0.379456370036359 0.672226586573033 GO:0043395 heparan sulfate proteoglycan binding 3/2155 19/18639 0.157894736842105 1.36566125290023 0.379456370036359 0.672226586573033 GO:0005548 phospholipid transporter activity 9/2155 68/18639 0.132352941176471 1.1447454619899 0.386732215567097 0.684133173305927 GO:0015291 secondary active transmembrane transporter activity 35/2155 287/18639 0.121951219512195 1.05477901646766 0.394826952590753 0.697185775944517 GO:0030159 signaling receptor complex adaptor activity 7/2155 52/18639 0.134615384615385 1.16431376048545 0.39554169712264 0.697185775944517 GO:0030414 peptidase inhibitor activity 21/2155 169/18639 0.124260355029586 1.07475116352503 0.397124253639335 0.697185775944517 GO:0015171 amino acid transmembrane transporter activity 13/2155 102/18639 0.127450980392157 1.1023474819162 0.398625200616921 0.697185775944517 GO:0004866 endopeptidase inhibitor activity 20/2155 161/18639 0.124223602484472 1.07443328385525 0.401763596632521 0.697185775944517 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/2155 36/18639 0.138888888888889 1.20127610208817 0.40460047523524 0.697185775944517 GO:0016409 palmitoyltransferase activity 5/2155 36/18639 0.138888888888889 1.20127610208817 0.40460047523524 0.697185775944517 GO:0016866 intramolecular transferase activity 4/2155 28/18639 0.142857142857143 1.23559827643354 0.408871402672402 0.697185775944517 GO:0045499 chemorepellent activity 4/2155 28/18639 0.142857142857143 1.23559827643354 0.408871402672402 0.697185775944517 GO:0015026 coreceptor activity 8/2155 61/18639 0.131147540983607 1.13431972918489 0.409430695783268 0.697185775944517 GO:0004300 enoyl-CoA hydratase activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0005078 MAP-kinase scaffold activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0005165 neurotrophin receptor binding 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0005527 macrolide binding 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0008179 adenylate cyclase binding 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0015132 prostaglandin transmembrane transporter activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0015368 calcium:monoatomic cation antiporter activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0016423 tRNA (guanine) methyltransferase activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0016840 carbon-nitrogen lyase activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0031543 peptidyl-proline dioxygenase activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0034452 dynactin binding 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0035259 nuclear glucocorticoid receptor binding 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0036009 protein-glutamine N-methyltransferase activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0045295 gamma-catenin binding 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0097371 MDM2/MDM4 family protein binding 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0097677 STAT family protein binding 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0140829 bicarbonate:monoatomic anion antiporter activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0140900 chloride:bicarbonate antiporter activity 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:1990459 transferrin receptor binding 2/2155 12/18639 0.166666666666667 1.4415313225058 0.411989357354206 0.697185775944517 GO:0000339 RNA cap binding 3/2155 20/18639 0.15 1.29737819025522 0.412204728843109 0.697185775944517 GO:0031418 L-ascorbic acid binding 3/2155 20/18639 0.15 1.29737819025522 0.412204728843109 0.697185775944517 GO:0017046 peptide hormone binding 7/2155 53/18639 0.132075471698113 1.14234557632535 0.41530987897987 0.701475453126273 GO:0019213 deacetylase activity 5/2155 37/18639 0.135135135135135 1.16880918041011 0.428489075692375 0.722745595524894 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 7/2155 54/18639 0.12962962962963 1.12119102861562 0.435025378393252 0.732768157867321 GO:0005126 cytokine receptor binding 33/2155 275/18639 0.12 1.03790255220418 0.437564871040986 0.736040226457756 GO:0001846 opsonin binding 3/2155 21/18639 0.142857142857143 1.23559827643354 0.444386145942173 0.740443402630675 GO:0005123 death receptor binding 3/2155 21/18639 0.142857142857143 1.23559827643354 0.444386145942173 0.740443402630675 GO:0005248 voltage-gated sodium channel activity 3/2155 21/18639 0.142857142857143 1.23559827643354 0.444386145942173 0.740443402630675 GO:0009931 calcium-dependent protein serine/threonine kinase activity 3/2155 21/18639 0.142857142857143 1.23559827643354 0.444386145942173 0.740443402630675 GO:0015174 basic amino acid transmembrane transporter activity 3/2155 21/18639 0.142857142857143 1.23559827643354 0.444386145942173 0.740443402630675 GO:0036122 BMP binding 3/2155 21/18639 0.142857142857143 1.23559827643354 0.444386145942173 0.740443402630675 GO:0061891 calcium ion sensor activity 3/2155 21/18639 0.142857142857143 1.23559827643354 0.444386145942173 0.740443402630675 GO:1901682 sulfur compound transmembrane transporter activity 8/2155 63/18639 0.126984126984127 1.09830957905204 0.446041289863479 0.741583843315578 GO:0008017 microtubule binding 33/2155 276/18639 0.119565217391304 1.03414203571068 0.446273488840356 0.741583843315578 GO:0000049 tRNA binding 10/2155 80/18639 0.125 1.08114849187935 0.447371082318257 0.742407193133796 GO:0000146 microfilament motor activity 5/2155 38/18639 0.131578947368421 1.13805104408353 0.452177575177065 0.743614723442167 GO:0005172 vascular endothelial growth factor receptor binding 2/2155 13/18639 0.153846153846154 1.33064429769766 0.453526579098548 0.743614723442167 GO:0008253 5'-nucleotidase activity 2/2155 13/18639 0.153846153846154 1.33064429769766 0.453526579098548 0.743614723442167 GO:0008417 fucosyltransferase activity 2/2155 13/18639 0.153846153846154 1.33064429769766 0.453526579098548 0.743614723442167 GO:0030955 potassium ion binding 2/2155 13/18639 0.153846153846154 1.33064429769766 0.453526579098548 0.743614723442167 GO:0039706 co-receptor binding 2/2155 13/18639 0.153846153846154 1.33064429769766 0.453526579098548 0.743614723442167 GO:0045159 myosin II binding 2/2155 13/18639 0.153846153846154 1.33064429769766 0.453526579098548 0.743614723442167 GO:0061459 L-arginine transmembrane transporter activity 2/2155 13/18639 0.153846153846154 1.33064429769766 0.453526579098548 0.743614723442167 GO:0071714 icosanoid transmembrane transporter activity 2/2155 13/18639 0.153846153846154 1.33064429769766 0.453526579098548 0.743614723442167 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 11/2155 89/18639 0.123595505617978 1.06900075601554 0.455381104836315 0.744674936688562 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 11/2155 89/18639 0.123595505617978 1.06900075601554 0.455381104836315 0.744674936688562 GO:0016769 transferase activity, transferring nitrogenous groups 4/2155 30/18639 0.133333333333333 1.15322505800464 0.462806381260438 0.754815169436666 GO:0033612 receptor serine/threonine kinase binding 4/2155 30/18639 0.133333333333333 1.15322505800464 0.462806381260438 0.754815169436666 GO:0001784 phosphotyrosine residue binding 6/2155 47/18639 0.127659574468085 1.10415165128104 0.464348872519774 0.75533266466607 GO:0140359 ABC-type transporter activity 6/2155 47/18639 0.127659574468085 1.10415165128104 0.464348872519774 0.75533266466607 GO:0016874 ligase activity 20/2155 167/18639 0.119760479041916 1.03583089042333 0.469196253110678 0.762212094974263 GO:0140793 histone H2AXY142 phosphatase activity 11/2155 90/18639 0.122222222222222 1.05712296983759 0.470698555198395 0.763646471788975 GO:0016776 phosphotransferase activity, phosphate group as acceptor 5/2155 39/18639 0.128205128205128 1.10887024808138 0.475592795090701 0.769967678022524 GO:0140784 metal ion sensor activity 3/2155 22/18639 0.136363636363636 1.17943471841384 0.475843771819273 0.769967678022524 GO:0017147 Wnt-protein binding 4/2155 31/18639 0.129032258064516 1.11602424968191 0.489126194752789 0.786892929760239 GO:0072349 modified amino acid transmembrane transporter activity 4/2155 31/18639 0.129032258064516 1.11602424968191 0.489126194752789 0.786892929760239 GO:0004705 JUN kinase activity 2/2155 14/18639 0.142857142857143 1.23559827643354 0.493323791325762 0.786892929760239 GO:0005344 oxygen carrier activity 2/2155 14/18639 0.142857142857143 1.23559827643354 0.493323791325762 0.786892929760239 GO:0008174 mRNA methyltransferase activity 2/2155 14/18639 0.142857142857143 1.23559827643354 0.493323791325762 0.786892929760239 GO:0008191 metalloendopeptidase inhibitor activity 2/2155 14/18639 0.142857142857143 1.23559827643354 0.493323791325762 0.786892929760239 GO:0008474 palmitoyl-(protein) hydrolase activity 2/2155 14/18639 0.142857142857143 1.23559827643354 0.493323791325762 0.786892929760239 GO:0019992 diacylglycerol binding 2/2155 14/18639 0.142857142857143 1.23559827643354 0.493323791325762 0.786892929760239 GO:0042813 Wnt receptor activity 2/2155 14/18639 0.142857142857143 1.23559827643354 0.493323791325762 0.786892929760239 GO:0098599 palmitoyl hydrolase activity 2/2155 14/18639 0.142857142857143 1.23559827643354 0.493323791325762 0.786892929760239 GO:1990825 sequence-specific mRNA binding 2/2155 14/18639 0.142857142857143 1.23559827643354 0.493323791325762 0.786892929760239 GO:0015036 disulfide oxidoreductase activity 5/2155 40/18639 0.125 1.08114849187935 0.498668116650752 0.794389906757593 GO:0031681 G-protein beta-subunit binding 3/2155 23/18639 0.130434782608696 1.12815494804802 0.506447241286593 0.804702897559754 GO:0140103 catalytic activity, acting on a glycoprotein 3/2155 23/18639 0.130434782608696 1.12815494804802 0.506447241286593 0.804702897559754 GO:0140142 nucleocytoplasmic carrier activity 4/2155 32/18639 0.125 1.08114849187935 0.514897560927769 0.817076824483834 GO:0017080 sodium channel regulator activity 5/2155 41/18639 0.121951219512195 1.05477901646766 0.521343527177081 0.82624237661869 GO:0000774 adenyl-nucleotide exchange factor activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0004467 long-chain fatty acid-CoA ligase activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0004953 icosanoid receptor activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0005041 low-density lipoprotein particle receptor activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0005523 tropomyosin binding 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0008252 nucleotidase activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0015929 hexosaminidase activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0031386 protein tag activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0033130 acetylcholine receptor binding 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0050780 dopamine receptor binding 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0141047 molecular tag activity 2/2155 15/18639 0.133333333333333 1.15322505800464 0.531227995837041 0.828070946734604 GO:0030215 semaphorin receptor binding 3/2155 24/18639 0.125 1.08114849187935 0.536090653482269 0.833166777447502 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 3/2155 24/18639 0.125 1.08114849187935 0.536090653482269 0.833166777447502 GO:0008514 organic anion transmembrane transporter activity 31/2155 269/18639 0.115241635687732 0.996746565004011 0.536524267066761 0.833166777447502 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 10/2155 86/18639 0.116279069767442 1.00571952732963 0.542537916729077 0.841445599153399 GO:0042056 chemoattractant activity 5/2155 42/18639 0.119047619047619 1.02966523036129 0.54356557843778 0.841980349514802 GO:0051427 hormone receptor binding 4/2155 34/18639 0.117647058823529 1.0175515217688 0.564514195419779 0.865457340359322 GO:0090482 vitamin transmembrane transporter activity 4/2155 34/18639 0.117647058823529 1.0175515217688 0.564514195419779 0.865457340359322 GO:0000030 mannosyltransferase activity 3/2155 25/18639 0.12 1.03790255220418 0.564690433423808 0.865457340359322 GO:0001848 complement binding 3/2155 25/18639 0.12 1.03790255220418 0.564690433423808 0.865457340359322 GO:0015645 fatty acid ligase activity 3/2155 25/18639 0.12 1.03790255220418 0.564690433423808 0.865457340359322 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/2155 25/18639 0.12 1.03790255220418 0.564690433423808 0.865457340359322 GO:0120515 fatty acid-CoA ligase activity 3/2155 25/18639 0.12 1.03790255220418 0.564690433423808 0.865457340359322 GO:0005149 interleukin-1 receptor binding 2/2155 16/18639 0.125 1.08114849187935 0.567144794006758 0.865457340359322 GO:0005521 lamin binding 2/2155 16/18639 0.125 1.08114849187935 0.567144794006758 0.865457340359322 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/2155 16/18639 0.125 1.08114849187935 0.567144794006758 0.865457340359322 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 2/2155 16/18639 0.125 1.08114849187935 0.567144794006758 0.865457340359322 GO:0097027 ubiquitin-protein transferase activator activity 2/2155 16/18639 0.125 1.08114849187935 0.567144794006758 0.865457340359322 GO:0016836 hydro-lyase activity 7/2155 61/18639 0.114754098360656 0.992529763036781 0.567991367777743 0.865677820111195 GO:0033218 amide binding 28/2155 247/18639 0.11336032388664 0.980474745671962 0.574434548322565 0.874417034668793 GO:0005544 calcium-dependent phospholipid binding 6/2155 53/18639 0.113207547169811 0.979153351136015 0.585822802245165 0.890535569302871 GO:0030020 extracellular matrix structural constituent conferring tensile strength 5/2155 44/18639 0.113636363636364 0.982862265344864 0.586467868835305 0.890535569302871 GO:0031406 carboxylic acid binding 21/2155 187/18639 0.112299465240642 0.971299179870218 0.591000628984574 0.892618375942918 GO:0004529 DNA exonuclease activity 3/2155 26/18639 0.115384615384615 0.997983223273247 0.592183156140557 0.892618375942918 GO:0008198 ferrous iron binding 3/2155 26/18639 0.115384615384615 0.997983223273247 0.592183156140557 0.892618375942918 GO:0019865 immunoglobulin binding 3/2155 26/18639 0.115384615384615 0.997983223273247 0.592183156140557 0.892618375942918 GO:0097602 cullin family protein binding 3/2155 26/18639 0.115384615384615 0.997983223273247 0.592183156140557 0.892618375942918 GO:0120014 phospholipid transfer activity 3/2155 26/18639 0.115384615384615 0.997983223273247 0.592183156140557 0.892618375942918 GO:0004659 prenyltransferase activity 2/2155 17/18639 0.117647058823529 1.0175515217688 0.601026891963347 0.900444906185671 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 2/2155 17/18639 0.117647058823529 1.0175515217688 0.601026891963347 0.900444906185671 GO:0015347 sodium-independent organic anion transmembrane transporter activity 2/2155 17/18639 0.117647058823529 1.0175515217688 0.601026891963347 0.900444906185671 GO:0036041 long-chain fatty acid binding 2/2155 17/18639 0.117647058823529 1.0175515217688 0.601026891963347 0.900444906185671 GO:0070403 NAD+ binding 2/2155 17/18639 0.117647058823529 1.0175515217688 0.601026891963347 0.900444906185671 GO:0005507 copper ion binding 7/2155 63/18639 0.111111111111111 0.961020881670534 0.603313197127068 0.902773267060285 GO:0042605 peptide antigen binding 5/2155 45/18639 0.111111111111111 0.961020881670534 0.607072678990029 0.907297712963279 GO:0045505 dynein intermediate chain binding 4/2155 36/18639 0.111111111111111 0.961020881670534 0.611201885883347 0.911337529431379 GO:0043177 organic acid binding 21/2155 189/18639 0.111111111111111 0.961020881670534 0.611253963373682 0.911337529431379 GO:0004620 phospholipase activity 12/2155 109/18639 0.110091743119266 0.952204176334107 0.616481665432299 0.918021610480706 GO:0005104 fibroblast growth factor receptor binding 3/2155 27/18639 0.111111111111111 0.961020881670534 0.618523394201435 0.91995095904749 GO:0052689 carboxylic ester hydrolase activity 10/2155 92/18639 0.108695652173913 0.940129123373348 0.631000936991119 0.93676098691959 GO:0004706 JUN kinase kinase kinase activity 2/2155 18/18639 0.111111111111111 0.961020881670534 0.632864478592067 0.93676098691959 GO:0017128 phospholipid scramblase activity 2/2155 18/18639 0.111111111111111 0.961020881670534 0.632864478592067 0.93676098691959 GO:0031690 adrenergic receptor binding 2/2155 18/18639 0.111111111111111 0.961020881670534 0.632864478592067 0.93676098691959 GO:0030170 pyridoxal phosphate binding 6/2155 56/18639 0.107142857142857 0.926698707325157 0.6409149730418 0.947539762302805 GO:0008238 exopeptidase activity 11/2155 102/18639 0.107843137254902 0.9327555616214 0.643298597088194 0.949353413537087 GO:0051959 dynein light intermediate chain binding 3/2155 28/18639 0.107142857142857 0.926698707325157 0.643681633184919 0.949353413537087 GO:0005504 fatty acid binding 5/2155 47/18639 0.106382978723404 0.920126376067532 0.646444659674943 0.952289444897497 GO:0008237 metallopeptidase activity 20/2155 184/18639 0.108695652173913 0.940129123373348 0.650321395641454 0.956857137023762 GO:0016298 lipase activity 14/2155 130/18639 0.107692307692308 0.931451008388363 0.652369274197488 0.958726239672828 GO:0070279 vitamin B6 binding 6/2155 57/18639 0.105263157894737 0.910440835266821 0.658269136579257 0.964676486663427 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 2/2155 19/18639 0.105263157894737 0.910440835266821 0.66267719724568 0.964676486663427 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 2/2155 19/18639 0.105263157894737 0.910440835266821 0.66267719724568 0.964676486663427 GO:0008574 plus-end-directed microtubule motor activity 2/2155 19/18639 0.105263157894737 0.910440835266821 0.66267719724568 0.964676486663427 GO:0022821 solute:potassium antiporter activity 2/2155 19/18639 0.105263157894737 0.910440835266821 0.66267719724568 0.964676486663427 GO:0031420 alkali metal ion binding 2/2155 19/18639 0.105263157894737 0.910440835266821 0.66267719724568 0.964676486663427 GO:0046624 sphingolipid transporter activity 2/2155 19/18639 0.105263157894737 0.910440835266821 0.66267719724568 0.964676486663427 GO:0097001 ceramide binding 2/2155 19/18639 0.105263157894737 0.910440835266821 0.66267719724568 0.964676486663427 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 5/2155 48/18639 0.104166666666667 0.900957076566125 0.665170011241542 0.967163471533987 GO:0035250 UDP-galactosyltransferase activity 3/2155 29/18639 0.103448275862069 0.894743579486359 0.667642286628119 0.967336004009954 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/2155 29/18639 0.103448275862069 0.894743579486359 0.667642286628119 0.967336004009954 GO:0099604 ligand-gated calcium channel activity 3/2155 29/18639 0.103448275862069 0.894743579486359 0.667642286628119 0.967336004009954 GO:0016757 glycosyltransferase activity 29/2155 267/18639 0.108614232209738 0.939424906801533 0.669130000236253 0.968353627102464 GO:0016247 channel regulator activity 18/2155 168/18639 0.107142857142857 0.926698707325157 0.670672409966345 0.969447926715714 GO:0019842 vitamin binding 16/2155 150/18639 0.106666666666667 0.922580046403712 0.672411823318123 0.970824096195838 GO:0050660 flavin adenine dinucleotide binding 9/2155 86/18639 0.104651162790698 0.905147574596666 0.674954831326769 0.971307048315769 GO:0099106 ion channel regulator activity 17/2155 160/18639 0.10625 0.918976218097448 0.681570129448952 0.971307048315769 GO:0016763 pentosyltransferase activity 5/2155 49/18639 0.102040816326531 0.882570197452531 0.683235263055847 0.971307048315769 GO:0003777 microtubule motor activity 7/2155 68/18639 0.102941176470588 0.8903575815477 0.68444403805163 0.971307048315769 GO:0141108 transporter regulator activity 18/2155 170/18639 0.105882352941176 0.91579636959192 0.690239536741359 0.971307048315769 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 3/2155 30/18639 0.1 0.86491879350348 0.690401831668972 0.971307048315769 GO:0048019 receptor antagonist activity 3/2155 30/18639 0.1 0.86491879350348 0.690401831668972 0.971307048315769 GO:0010851 cyclase regulator activity 2/2155 20/18639 0.1 0.86491879350348 0.690507471512631 0.971307048315769 GO:0016408 C-acyltransferase activity 2/2155 20/18639 0.1 0.86491879350348 0.690507471512631 0.971307048315769 GO:0016505 peptidase activator activity involved in apoptotic process 2/2155 20/18639 0.1 0.86491879350348 0.690507471512631 0.971307048315769 GO:0140939 histone H4 methyltransferase activity 2/2155 20/18639 0.1 0.86491879350348 0.690507471512631 0.971307048315769 GO:0001786 phosphatidylserine binding 6/2155 59/18639 0.101694915254237 0.879578434071336 0.691372687175975 0.971307048315769 GO:0003730 mRNA 3'-UTR binding 28/2155 262/18639 0.106870229007634 0.924340695347231 0.70049177513919 0.971307048315769 GO:0008083 growth factor activity 17/2155 162/18639 0.104938271604938 0.907630832688837 0.70127696487731 0.971307048315769 GO:0016835 carbon-oxygen lyase activity 8/2155 79/18639 0.10126582278481 0.875867132661752 0.707019439398947 0.971307048315769 GO:0033293 monocarboxylic acid binding 8/2155 79/18639 0.10126582278481 0.875867132661752 0.707019439398947 0.971307048315769 GO:0003796 lysozyme activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0004935 adrenergic receptor activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0005337 nucleoside transmembrane transporter activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0005522 profilin binding 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0005528 FK506 binding 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0008401 retinoic acid 4-hydroxylase activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0015279 store-operated calcium channel activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0016427 tRNA (cytidine) methyltransferase activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0016783 sulfurtransferase activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0019531 oxalate transmembrane transporter activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0032052 bile acid binding 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0032356 oxidized DNA binding 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0035256 G protein-coupled glutamate receptor binding 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0035374 chondroitin sulfate binding 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0043295 glutathione binding 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0070097 delta-catenin binding 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0141109 transporter activator activity 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:1905394 retromer complex binding 1/2155 10/18639 0.1 0.86491879350348 0.70740772861927 0.971307048315769 GO:0005452 solute:inorganic anion antiporter activity 3/2155 31/18639 0.0967741935483871 0.837018187261433 0.711967078481421 0.97606593335174 GO:0042287 MHC protein binding 4/2155 41/18639 0.0975609756097561 0.843823213174127 0.713480072665911 0.97606593335174 GO:0019200 carbohydrate kinase activity 2/2155 21/18639 0.0952380952380952 0.823732184289029 0.716414979467417 0.97606593335174 GO:0051010 microtubule plus-end binding 2/2155 21/18639 0.0952380952380952 0.823732184289029 0.716414979467417 0.97606593335174 GO:0051428 peptide hormone receptor binding 2/2155 21/18639 0.0952380952380952 0.823732184289029 0.716414979467417 0.97606593335174 GO:0070182 DNA polymerase binding 2/2155 21/18639 0.0952380952380952 0.823732184289029 0.716414979467417 0.97606593335174 GO:0140312 cargo adaptor activity 2/2155 21/18639 0.0952380952380952 0.823732184289029 0.716414979467417 0.97606593335174 GO:0030544 Hsp70 protein binding 5/2155 51/18639 0.0980392156862745 0.847959601474 0.717353030720554 0.976265217305125 GO:0048306 calcium-dependent protein binding 8/2155 80/18639 0.1 0.86491879350348 0.720358767378005 0.979274928530408 GO:0008378 galactosyltransferase activity 3/2155 32/18639 0.09375 0.810861368909513 0.732353580297316 0.982760342899911 GO:0030515 snoRNA binding 3/2155 32/18639 0.09375 0.810861368909513 0.732353580297316 0.982760342899911 GO:0042910 xenobiotic transmembrane transporter activity 3/2155 32/18639 0.09375 0.810861368909513 0.732353580297316 0.982760342899911 GO:0072341 modified amino acid binding 9/2155 91/18639 0.0989010989010989 0.855414191377068 0.738933629287717 0.982760342899911 GO:0031683 G-protein beta/gamma-subunit complex binding 2/2155 22/18639 0.0909090909090909 0.786289812275891 0.740472100232231 0.982760342899911 GO:0000099 sulfur amino acid transmembrane transporter activity 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0001851 complement component C3b binding 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0004143 ATP-dependent diacylglycerol kinase activity 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0008199 ferric iron binding 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0008271 secondary active sulfate transmembrane transporter activity 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0015217 ADP transmembrane transporter activity 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0019206 nucleoside kinase activity 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0019864 IgG binding 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0032404 mismatch repair complex binding 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0035252 UDP-xylosyltransferase activity 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0042285 xylosyltransferase activity 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0042608 T cell receptor binding 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0070990 snRNP binding 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:1900750 oligopeptide binding 1/2155 11/18639 0.0909090909090909 0.786289812275891 0.741254759851514 0.982760342899911 GO:0005246 calcium channel regulator activity 5/2155 53/18639 0.0943396226415094 0.815961125946679 0.748771692926074 0.991660040148066 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/2155 33/18639 0.0909090909090909 0.786289812275891 0.751584185976501 0.993251126804957 GO:0019956 chemokine binding 3/2155 33/18639 0.0909090909090909 0.786289812275891 0.751584185976501 0.993251126804957 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/2155 23/18639 0.0869565217391304 0.752103298698678 0.762760182036577 0.995680394968612 GO:0005283 amino acid:sodium symporter activity 2/2155 23/18639 0.0869565217391304 0.752103298698678 0.762760182036577 0.995680394968612 GO:0008171 O-methyltransferase activity 2/2155 23/18639 0.0869565217391304 0.752103298698678 0.762760182036577 0.995680394968612 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 2/2155 23/18639 0.0869565217391304 0.752103298698678 0.762760182036577 0.995680394968612 GO:0050661 NADP binding 5/2155 54/18639 0.0925925925925926 0.800850734725445 0.763475694221934 0.995680394968612 GO:0004536 DNA nuclease activity 6/2155 64/18639 0.09375 0.810861368909513 0.764466296807726 0.995680394968612 GO:0016758 hexosyltransferase activity 20/2155 197/18639 0.101522842639594 0.878090145688812 0.764511603091216 0.995680394968612 GO:0046943 carboxylic acid transmembrane transporter activity 19/2155 188/18639 0.101063829787234 0.874120057264156 0.766939482317553 0.995680394968612 GO:0008175 tRNA methyltransferase activity 3/2155 34/18639 0.0882352941176471 0.7631636413266 0.769687733449732 0.995680394968612 GO:0008376 acetylgalactosaminyltransferase activity 3/2155 34/18639 0.0882352941176471 0.7631636413266 0.769687733449732 0.995680394968612 GO:0015020 glucuronosyltransferase activity 3/2155 34/18639 0.0882352941176471 0.7631636413266 0.769687733449732 0.995680394968612 GO:0015035 protein-disulfide reductase activity 3/2155 34/18639 0.0882352941176471 0.7631636413266 0.769687733449732 0.995680394968612 GO:0016831 carboxy-lyase activity 3/2155 34/18639 0.0882352941176471 0.7631636413266 0.769687733449732 0.995680394968612 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2155 12/18639 0.0833333333333333 0.7207656612529 0.77118797826036 0.995680394968612 GO:0004000 adenosine deaminase activity 1/2155 12/18639 0.0833333333333333 0.7207656612529 0.77118797826036 0.995680394968612 GO:0004126 cytidine deaminase activity 1/2155 12/18639 0.0833333333333333 0.7207656612529 0.77118797826036 0.995680394968612 GO:0005436 sodium:phosphate symporter activity 1/2155 12/18639 0.0833333333333333 0.7207656612529 0.77118797826036 0.995680394968612 GO:0015269 calcium-activated potassium channel activity 1/2155 12/18639 0.0833333333333333 0.7207656612529 0.77118797826036 0.995680394968612 GO:0035251 UDP-glucosyltransferase activity 1/2155 12/18639 0.0833333333333333 0.7207656612529 0.77118797826036 0.995680394968612 GO:0042301 phosphate ion binding 1/2155 12/18639 0.0833333333333333 0.7207656612529 0.77118797826036 0.995680394968612 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 1/2155 12/18639 0.0833333333333333 0.7207656612529 0.77118797826036 0.995680394968612 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization 1/2155 12/18639 0.0833333333333333 0.7207656612529 0.77118797826036 0.995680394968612 GO:0005342 organic acid transmembrane transporter activity 19/2155 189/18639 0.100529100529101 0.869495083416197 0.774717066709487 0.99919052641506 GO:0051539 4 iron, 4 sulfur cluster binding 4/2155 45/18639 0.0888888888888889 0.768816705336427 0.779960472736462 0.999999999587607 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 2/2155 24/18639 0.0833333333333333 0.7207656612529 0.783366502814242 0.999999999587607 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 2/2155 24/18639 0.0833333333333333 0.7207656612529 0.783366502814242 0.999999999587607 GO:0005540 hyaluronic acid binding 2/2155 24/18639 0.0833333333333333 0.7207656612529 0.783366502814242 0.999999999587607 GO:0030552 cAMP binding 2/2155 24/18639 0.0833333333333333 0.7207656612529 0.783366502814242 0.999999999587607 GO:0035035 histone acetyltransferase binding 2/2155 24/18639 0.0833333333333333 0.7207656612529 0.783366502814242 0.999999999587607 GO:0070300 phosphatidic acid binding 2/2155 24/18639 0.0833333333333333 0.7207656612529 0.783366502814242 0.999999999587607 GO:0140612 DNA damage sensor activity 2/2155 24/18639 0.0833333333333333 0.7207656612529 0.783366502814242 0.999999999587607 GO:0005343 organic acid:sodium symporter activity 3/2155 35/18639 0.0857142857142857 0.741358965860126 0.786697879686665 0.999999999587607 GO:0043015 gamma-tubulin binding 3/2155 35/18639 0.0857142857142857 0.741358965860126 0.786697879686665 0.999999999587607 GO:0003774 cytoskeletal motor activity 15/2155 153/18639 0.0980392156862745 0.847959601474 0.787812475401916 0.999999999587607 GO:0008235 metalloexopeptidase activity 6/2155 66/18639 0.0909090909090909 0.786289812275891 0.789834743622773 0.999999999587607 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 4/2155 46/18639 0.0869565217391304 0.752103298698678 0.794521206575706 0.999999999587607 GO:0005506 iron ion binding 15/2155 154/18639 0.0974025974025974 0.842453370295598 0.795903340030408 0.999999999587607 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:0031432 titin binding 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:0035325 Toll-like receptor binding 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:0035673 oligopeptide transmembrane transporter activity 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:0051011 microtubule minus-end binding 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:0070700 BMP receptor binding 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:0086080 protein binding involved in heterotypic cell-cell adhesion 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:1901338 catecholamine binding 1/2155 13/18639 0.0769230769230769 0.665322148848831 0.797659761523845 0.999999999587607 GO:0015081 sodium ion transmembrane transporter activity 16/2155 164/18639 0.0975609756097561 0.843823213174127 0.799748066485904 0.999999999587607 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 6/2155 67/18639 0.0895522388059701 0.774554143435953 0.801710353110808 0.999999999587607 GO:0015271 outward rectifier potassium channel activity 2/2155 25/18639 0.08 0.691935034802784 0.802381813196019 0.999999999587607 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 3/2155 36/18639 0.0833333333333333 0.7207656612529 0.802652060941512 0.999999999587607 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 3/2155 36/18639 0.0833333333333333 0.7207656612529 0.802652060941512 0.999999999587607 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 3/2155 36/18639 0.0833333333333333 0.7207656612529 0.802652060941512 0.999999999587607 GO:0140375 immune receptor activity 15/2155 156/18639 0.0961538461538462 0.831652686061039 0.81142236014349 0.999999999587607 GO:0015085 calcium ion transmembrane transporter activity 14/2155 147/18639 0.0952380952380952 0.823732184289029 0.81597258953884 0.999999999587607 GO:0004112 cyclic-nucleotide phosphodiesterase activity 2/2155 26/18639 0.0769230769230769 0.665322148848831 0.81989836795064 0.999999999587607 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 2/2155 26/18639 0.0769230769230769 0.665322148848831 0.81989836795064 0.999999999587607 GO:0030507 spectrin binding 2/2155 26/18639 0.0769230769230769 0.665322148848831 0.81989836795064 0.999999999587607 GO:0051139 metal cation:proton antiporter activity 2/2155 26/18639 0.0769230769230769 0.665322148848831 0.81989836795064 0.999999999587607 GO:0005313 L-glutamate transmembrane transporter activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0008331 high voltage-gated calcium channel activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0008559 ABC-type xenobiotic transporter activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0015386 potassium:proton antiporter activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0015926 glucosidase activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0016530 metallochaperone activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0019763 immunoglobulin receptor activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0030983 mismatched DNA binding 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0032036 myosin heavy chain binding 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0042043 neurexin family protein binding 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0043176 amine binding 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0061783 peptidoglycan muralytic activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:1901474 azole transmembrane transporter activity 1/2155 14/18639 0.0714285714285714 0.617799138216772 0.821070220769851 0.999999999587607 GO:0004222 metalloendopeptidase activity 10/2155 110/18639 0.0909090909090909 0.786289812275891 0.831760438069711 0.999999999587607 GO:0097110 scaffold protein binding 6/2155 70/18639 0.0857142857142857 0.741358965860126 0.834216685855251 0.999999999587607 GO:0004364 glutathione transferase activity 2/2155 27/18639 0.0740740740740741 0.640680587780356 0.836008365850577 0.999999999587607 GO:0008395 steroid hydroxylase activity 2/2155 27/18639 0.0740740740740741 0.640680587780356 0.836008365850577 0.999999999587607 GO:0035255 ionotropic glutamate receptor binding 2/2155 27/18639 0.0740740740740741 0.640680587780356 0.836008365850577 0.999999999587607 GO:0005262 calcium channel activity 12/2155 131/18639 0.0916030534351145 0.792292024583341 0.841687172089722 0.999999999587607 GO:0004089 carbonate dehydratase activity 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0008020 G protein-coupled photoreceptor activity 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0008242 omega peptidase activity 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0015116 sulfate transmembrane transporter activity 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0015556 C4-dicarboxylate transmembrane transporter activity 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0016846 carbon-sulfur lyase activity 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0017081 chloride channel regulator activity 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0031005 filamin binding 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0045504 dynein heavy chain binding 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0140161 monocarboxylate:sodium symporter activity 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0140776 protein-containing complex destabilizing activity 1/2155 15/18639 0.0666666666666667 0.57661252900232 0.841773236836481 0.999999999587607 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3/2155 39/18639 0.0769230769230769 0.665322148848831 0.844591401568747 0.999999999587607 GO:0032813 tumor necrosis factor receptor superfamily binding 4/2155 50/18639 0.08 0.691935034802784 0.845141043275143 0.999999999587607 GO:0016829 lyase activity 19/2155 200/18639 0.095 0.821672853828306 0.848697947284196 0.999999999587607 GO:0046625 sphingolipid binding 2/2155 28/18639 0.0714285714285714 0.617799138216772 0.850802729901782 0.999999999587607 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/2155 40/18639 0.075 0.64868909512761 0.856741917060451 0.999999999587607 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 3/2155 40/18639 0.075 0.64868909512761 0.856741917060451 0.999999999587607 GO:0061791 GTPase motor activity 3/2155 40/18639 0.075 0.64868909512761 0.856741917060451 0.999999999587607 GO:1990606 membrane scission GTPase motor activity 3/2155 40/18639 0.075 0.64868909512761 0.856741917060451 0.999999999587607 GO:0000062 fatty-acyl-CoA binding 1/2155 16/18639 0.0625 0.540574245939675 0.860081799691795 0.999999999587607 GO:0003688 DNA replication origin binding 1/2155 16/18639 0.0625 0.540574245939675 0.860081799691795 0.999999999587607 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 1/2155 16/18639 0.0625 0.540574245939675 0.860081799691795 0.999999999587607 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/2155 16/18639 0.0625 0.540574245939675 0.860081799691795 0.999999999587607 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/2155 16/18639 0.0625 0.540574245939675 0.860081799691795 0.999999999587607 GO:0022841 potassium ion leak channel activity 1/2155 16/18639 0.0625 0.540574245939675 0.860081799691795 0.999999999587607 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/2155 16/18639 0.0625 0.540574245939675 0.860081799691795 0.999999999587607 GO:0022804 active transmembrane transporter activity 46/2155 457/18639 0.100656455142232 0.870596597399564 0.862316935793403 0.999999999587607 GO:0004181 metallocarboxypeptidase activity 2/2155 29/18639 0.0689655172413793 0.596495719657573 0.864370170144275 0.999999999587607 GO:0005416 amino acid:monoatomic cation symporter activity 2/2155 29/18639 0.0689655172413793 0.596495719657573 0.864370170144275 0.999999999587607 GO:0004812 aminoacyl-tRNA ligase activity 3/2155 41/18639 0.0731707317073171 0.632867409880595 0.868052062670546 0.999999999587607 GO:0016875 ligase activity, forming carbon-oxygen bonds 3/2155 41/18639 0.0731707317073171 0.632867409880595 0.868052062670546 0.999999999587607 GO:0008194 UDP-glycosyltransferase activity 13/2155 145/18639 0.0896551724137931 0.775444435554844 0.869169072679205 0.999999999587607 GO:0048029 monosaccharide binding 6/2155 74/18639 0.0810810810810811 0.701285508246065 0.870731721462186 0.999999999587607 GO:0004864 protein phosphatase inhibitor activity 4/2155 53/18639 0.0754716981132075 0.652768900757344 0.875823560933904 0.999999999587607 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:0008569 minus-end-directed microtubule motor activity 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:0016018 cyclosporin A binding 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:0019198 transmembrane receptor protein phosphatase activity 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:0030548 acetylcholine receptor regulator activity 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:0031489 myosin V binding 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:0032977 membrane insertase activity 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:0045236 CXCR chemokine receptor binding 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:1901567 fatty acid derivative binding 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:1990226 histone methyltransferase binding 1/2155 17/18639 0.0588235294117647 0.5087757608844 0.876272731424823 0.999999999587607 GO:0004175 endopeptidase activity 40/2155 405/18639 0.0987654320987654 0.854240783707141 0.876619155076093 0.999999999587607 GO:0004497 monooxygenase activity 9/2155 106/18639 0.0849056603773585 0.734365013352012 0.877061022813918 0.999999999587607 GO:0004520 DNA endonuclease activity 3/2155 42/18639 0.0714285714285714 0.617799138216772 0.878566389883631 0.999999999587607 GO:0016859 cis-trans isomerase activity 3/2155 42/18639 0.0714285714285714 0.617799138216772 0.878566389883631 0.999999999587607 GO:0044183 protein folding chaperone 6/2155 75/18639 0.08 0.691935034802784 0.878733650741579 0.999999999587607 GO:0019843 rRNA binding 5/2155 65/18639 0.0769230769230769 0.665322148848831 0.884651568120999 0.999999999587607 GO:0005310 dicarboxylic acid transmembrane transporter activity 2/2155 31/18639 0.0645161290322581 0.558012124840955 0.888164024970123 0.999999999587607 GO:0005245 voltage-gated calcium channel activity 3/2155 43/18639 0.0697674418604651 0.603431716397777 0.888328906234124 0.999999999587607 GO:0008375 acetylglucosaminyltransferase activity 3/2155 43/18639 0.0697674418604651 0.603431716397777 0.888328906234124 0.999999999587607 GO:0008409 5'-3' exonuclease activity 1/2155 18/18639 0.0555555555555556 0.480510440835267 0.890590863944397 0.999999999587607 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/2155 18/18639 0.0555555555555556 0.480510440835267 0.890590863944397 0.999999999587607 GO:0035615 clathrin adaptor activity 1/2155 18/18639 0.0555555555555556 0.480510440835267 0.890590863944397 0.999999999587607 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism 1/2155 18/18639 0.0555555555555556 0.480510440835267 0.890590863944397 0.999999999587607 GO:0099602 neurotransmitter receptor regulator activity 1/2155 18/18639 0.0555555555555556 0.480510440835267 0.890590863944397 0.999999999587607 GO:1901611 phosphatidylglycerol binding 1/2155 18/18639 0.0555555555555556 0.480510440835267 0.890590863944397 0.999999999587607 GO:0042626 ATPase-coupled transmembrane transporter activity 8/2155 98/18639 0.0816326530612245 0.706056157962025 0.892283601039141 0.999999999587607 GO:0016651 oxidoreductase activity, acting on NAD(P)H 7/2155 88/18639 0.0795454545454545 0.688003585741405 0.895642635194187 0.999999999587607 GO:0019205 nucleobase-containing compound kinase activity 3/2155 44/18639 0.0681818181818182 0.589717359206918 0.897382777262385 0.999999999587607 GO:0030547 signaling receptor inhibitor activity 3/2155 44/18639 0.0681818181818182 0.589717359206918 0.897382777262385 0.999999999587607 GO:0015106 bicarbonate transmembrane transporter activity 2/2155 32/18639 0.0625 0.540574245939675 0.89855138794831 0.999999999587607 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/2155 32/18639 0.0625 0.540574245939675 0.89855138794831 0.999999999587607 GO:0008173 RNA methyltransferase activity 5/2155 67/18639 0.0746268656716418 0.645461786196627 0.899739010422695 0.999999999587607 GO:0019212 phosphatase inhibitor activity 4/2155 56/18639 0.0714285714285714 0.617799138216772 0.901096874742332 0.999999999587607 GO:0170055 lipid transmembrane transporter activity 4/2155 56/18639 0.0714285714285714 0.617799138216772 0.901096874742332 0.999999999587607 GO:0008301 DNA binding, bending 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0015245 fatty acid transmembrane transporter activity 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0016918 retinal binding 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0022840 leak channel activity 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0022842 narrow pore channel activity 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0030506 ankyrin binding 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0034987 immunoglobulin receptor binding 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0046527 glucosyltransferase activity 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0050145 nucleoside monophosphate kinase activity 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0070003 threonine-type peptidase activity 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0120227 acyl-CoA binding 1/2155 19/18639 0.0526315789473684 0.455220417633411 0.903252734316548 0.999999999587607 GO:0019239 deaminase activity 2/2155 33/18639 0.0606060606060606 0.524193208183927 0.908033142914233 0.999999999587607 GO:0004180 carboxypeptidase activity 3/2155 46/18639 0.0652173913043478 0.564077474024009 0.913531634367091 0.999999999587607 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/2155 46/18639 0.0652173913043478 0.564077474024009 0.913531634367091 0.999999999587607 GO:0001972 retinoic acid binding 1/2155 20/18639 0.05 0.43245939675174 0.914449853411491 0.999999999587607 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 1/2155 20/18639 0.05 0.43245939675174 0.914449853411491 0.999999999587607 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2155 20/18639 0.05 0.43245939675174 0.914449853411491 0.999999999587607 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 1/2155 20/18639 0.05 0.43245939675174 0.914449853411491 0.999999999587607 GO:0030627 pre-mRNA 5'-splice site binding 1/2155 20/18639 0.05 0.43245939675174 0.914449853411491 0.999999999587607 GO:0030742 GTP-dependent protein binding 1/2155 20/18639 0.05 0.43245939675174 0.914449853411491 0.999999999587607 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 2/2155 34/18639 0.0588235294117647 0.5087757608844 0.916679731005764 0.999999999587607 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2/2155 34/18639 0.0588235294117647 0.5087757608844 0.916679731005764 0.999999999587607 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 2/2155 34/18639 0.0588235294117647 0.5087757608844 0.916679731005764 0.999999999587607 GO:0015125 bile acid transmembrane transporter activity 1/2155 21/18639 0.0476190476190476 0.411866092144514 0.924351597108695 0.999999999587607 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 1/2155 21/18639 0.0476190476190476 0.411866092144514 0.924351597108695 0.999999999587607 GO:0016229 steroid dehydrogenase activity 2/2155 35/18639 0.0571428571428571 0.494239310573417 0.924557418964498 0.999999999587607 GO:0016879 ligase activity, forming carbon-nitrogen bonds 3/2155 48/18639 0.0625 0.540574245939675 0.92733344735988 0.999999999587607 GO:0004519 endonuclease activity 10/2155 127/18639 0.078740157480315 0.681038420081481 0.932132355140751 0.999999999587607 GO:0008649 rRNA methyltransferase activity 1/2155 22/18639 0.0454545454545455 0.393144906137946 0.933107763626622 0.999999999587607 GO:0008970 phospholipase A1 activity 1/2155 22/18639 0.0454545454545455 0.393144906137946 0.933107763626622 0.999999999587607 GO:0015377 chloride:monoatomic cation symporter activity 1/2155 22/18639 0.0454545454545455 0.393144906137946 0.933107763626622 0.999999999587607 GO:0034062 5'-3' RNA polymerase activity 1/2155 22/18639 0.0454545454545455 0.393144906137946 0.933107763626622 0.999999999587607 GO:0097747 RNA polymerase activity 1/2155 22/18639 0.0454545454545455 0.393144906137946 0.933107763626622 0.999999999587607 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 4/2155 61/18639 0.0655737704918033 0.567159864592446 0.933224750417338 0.999999999587607 GO:0035254 glutamate receptor binding 3/2155 49/18639 0.0612244897959184 0.529542118471519 0.933447785482477 0.999999999587607 GO:0004521 RNA endonuclease activity 5/2155 73/18639 0.0684931506849315 0.59241013253663 0.935158820003753 0.999999999587607 GO:0140101 catalytic activity, acting on a tRNA 11/2155 139/18639 0.079136690647482 0.684468109966783 0.937489567583129 0.999999999587607 GO:0030551 cyclic nucleotide binding 2/2155 37/18639 0.0540540540540541 0.467523672164043 0.938250479328103 0.999999999587607 GO:0048020 CCR chemokine receptor binding 3/2155 50/18639 0.06 0.518951276102088 0.939084386048902 0.999999999587607 GO:0005212 structural constituent of eye lens 1/2155 23/18639 0.0434782608695652 0.376051649349339 0.940850835517078 0.999999999587607 GO:0099186 structural constituent of postsynapse 1/2155 23/18639 0.0434782608695652 0.376051649349339 0.940850835517078 0.999999999587607 GO:0140102 catalytic activity, acting on a rRNA 1/2155 23/18639 0.0434782608695652 0.376051649349339 0.940850835517078 0.999999999587607 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 10/2155 130/18639 0.0769230769230769 0.665322148848831 0.943004161252383 0.999999999587607 GO:0005109 frizzled binding 2/2155 38/18639 0.0526315789473684 0.455220417633411 0.944177962496143 0.999999999587607 GO:0005501 retinoid binding 2/2155 38/18639 0.0526315789473684 0.455220417633411 0.944177962496143 0.999999999587607 GO:0019840 isoprenoid binding 2/2155 38/18639 0.0526315789473684 0.455220417633411 0.944177962496143 0.999999999587607 GO:0004806 triacylglycerol lipase activity 1/2155 24/18639 0.0416666666666667 0.36038283062645 0.947697980417202 0.999999999587607 GO:0015149 hexose transmembrane transporter activity 1/2155 24/18639 0.0416666666666667 0.36038283062645 0.947697980417202 0.999999999587607 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 1/2155 24/18639 0.0416666666666667 0.36038283062645 0.947697980417202 0.999999999587607 GO:0019957 C-C chemokine binding 1/2155 24/18639 0.0416666666666667 0.36038283062645 0.947697980417202 0.999999999587607 GO:0042625 ATPase-coupled ion transmembrane transporter activity 1/2155 24/18639 0.0416666666666667 0.36038283062645 0.947697980417202 0.999999999587607 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 1/2155 24/18639 0.0416666666666667 0.36038283062645 0.947697980417202 0.999999999587607 GO:0046961 proton-transporting ATPase activity, rotational mechanism 1/2155 24/18639 0.0416666666666667 0.36038283062645 0.947697980417202 0.999999999587607 GO:0055056 D-glucose transmembrane transporter activity 1/2155 24/18639 0.0416666666666667 0.36038283062645 0.947697980417202 0.999999999587607 GO:0051536 iron-sulfur cluster binding 5/2155 76/18639 0.0657894736842105 0.569025522041763 0.948267112111719 0.999999999587607 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 2/2155 39/18639 0.0512820512820513 0.443548099232554 0.94956101984357 0.999999999587607 GO:0051540 metal cluster binding 5/2155 77/18639 0.0649350649350649 0.561635580197065 0.952071070740255 0.999999999587607 GO:0005251 delayed rectifier potassium channel activity 1/2155 25/18639 0.04 0.345967517401392 0.953752820718084 0.999999999587607 GO:0015296 monoatomic anion:monoatomic cation symporter activity 1/2155 25/18639 0.04 0.345967517401392 0.953752820718084 0.999999999587607 GO:0015662 P-type ion transporter activity 1/2155 25/18639 0.04 0.345967517401392 0.953752820718084 0.999999999587607 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 1/2155 25/18639 0.04 0.345967517401392 0.953752820718084 0.999999999587607 GO:0140358 P-type transmembrane transporter activity 1/2155 25/18639 0.04 0.345967517401392 0.953752820718084 0.999999999587607 GO:0071855 neuropeptide receptor binding 2/2155 40/18639 0.05 0.43245939675174 0.954446235779523 0.999999999587607 GO:0140662 ATP-dependent protein folding chaperone 2/2155 40/18639 0.05 0.43245939675174 0.954446235779523 0.999999999587607 GO:0017171 serine hydrolase activity 16/2155 198/18639 0.0808080808080808 0.69892427757857 0.956439673375488 0.999999999587607 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3/2155 54/18639 0.0555555555555556 0.480510440835267 0.95748544919892 0.999999999587607 GO:0051287 NAD binding 3/2155 54/18639 0.0555555555555556 0.480510440835267 0.95748544919892 0.999999999587607 GO:0001530 lipopolysaccharide binding 2/2155 41/18639 0.0487804878048781 0.421911606587064 0.958876706195368 0.999999999587607 GO:0008137 NADH dehydrogenase (ubiquinone) activity 2/2155 41/18639 0.0487804878048781 0.421911606587064 0.958876706195368 0.999999999587607 GO:0004435 phosphatidylinositol phospholipase C activity 1/2155 26/18639 0.0384615384615385 0.332661074424416 0.959106998828782 0.999999999587607 GO:0005227 calcium-activated cation channel activity 1/2155 26/18639 0.0384615384615385 0.332661074424416 0.959106998828782 0.999999999587607 GO:0015145 monosaccharide transmembrane transporter activity 1/2155 26/18639 0.0384615384615385 0.332661074424416 0.959106998828782 0.999999999587607 GO:0030247 polysaccharide binding 1/2155 26/18639 0.0384615384615385 0.332661074424416 0.959106998828782 0.999999999587607 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 6/2155 91/18639 0.0659340659340659 0.570276127584712 0.959772786453065 0.999999999587607 GO:0046873 metal ion transmembrane transporter activity 41/2155 450/18639 0.0911111111111111 0.788037122969838 0.960876699979097 0.999999999587607 GO:0016853 isomerase activity 14/2155 180/18639 0.0777777777777778 0.672714617169374 0.962703145368111 0.999999999587607 GO:0005044 scavenger receptor activity 1/2155 27/18639 0.037037037037037 0.320340293890178 0.963841561635636 0.999999999587607 GO:0015252 proton channel activity 1/2155 27/18639 0.037037037037037 0.320340293890178 0.963841561635636 0.999999999587607 GO:0023026 MHC class II protein complex binding 1/2155 27/18639 0.037037037037037 0.320340293890178 0.963841561635636 0.999999999587607 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2/2155 43/18639 0.0465116279069767 0.402287810931851 0.966529456926898 0.999999999587607 GO:0005242 inward rectifier potassium channel activity 1/2155 28/18639 0.0357142857142857 0.308899569108386 0.968028185033186 0.999999999587607 GO:0050698 proteoglycan sulfotransferase activity 1/2155 28/18639 0.0357142857142857 0.308899569108386 0.968028185033186 0.999999999587607 GO:0051119 sugar transmembrane transporter activity 1/2155 28/18639 0.0357142857142857 0.308899569108386 0.968028185033186 0.999999999587607 GO:0051537 2 iron, 2 sulfur cluster binding 1/2155 28/18639 0.0357142857142857 0.308899569108386 0.968028185033186 0.999999999587607 GO:0016782 transferase activity, transferring sulphur-containing groups 4/2155 70/18639 0.0571428571428571 0.494239310573417 0.968261517784972 0.999999999587607 GO:0001664 G protein-coupled receptor binding 25/2155 297/18639 0.0841750841750842 0.728046122477677 0.968540315548649 0.999999999587607 GO:0008236 serine-type peptidase activity 15/2155 194/18639 0.077319587628866 0.668751644461454 0.96904097415642 0.999999999587607 GO:0003954 NADH dehydrogenase activity 2/2155 44/18639 0.0454545454545455 0.393144906137946 0.969822155958542 0.999999999587607 GO:0004629 phospholipase C activity 1/2155 29/18639 0.0344827586206897 0.298247859828786 0.971730256993505 0.999999999587607 GO:0042379 chemokine receptor binding 4/2155 72/18639 0.0555555555555556 0.480510440835267 0.973247301039102 0.999999999587607 GO:0005179 hormone activity 9/2155 132/18639 0.0681818181818182 0.589717359206918 0.974773688951697 0.999999999587607 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 9/2155 132/18639 0.0681818181818182 0.589717359206918 0.974773688951697 0.999999999587607 GO:0008106 alcohol dehydrogenase (NADP+) activity 1/2155 30/18639 0.0333333333333333 0.28830626450116 0.975003835509302 0.999999999587607 GO:0022839 monoatomic ion-gated channel activity 1/2155 30/18639 0.0333333333333333 0.28830626450116 0.975003835509302 0.999999999587607 GO:0098918 structural constituent of synapse 1/2155 30/18639 0.0333333333333333 0.28830626450116 0.975003835509302 0.999999999587607 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3/2155 60/18639 0.05 0.43245939675174 0.975584506257182 0.999999999587607 GO:0005249 voltage-gated potassium channel activity 6/2155 98/18639 0.0612244897959184 0.529542118471519 0.976183027909617 0.999999999587607 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 8/2155 122/18639 0.0655737704918033 0.567159864592446 0.977091076594645 0.999999999587607 GO:0005164 tumor necrosis factor receptor binding 1/2155 31/18639 0.032258064516129 0.279006062420477 0.977898495860609 0.999999999587607 GO:0005184 neuropeptide hormone activity 1/2155 31/18639 0.032258064516129 0.279006062420477 0.977898495860609 0.999999999587607 GO:0038187 pattern recognition receptor activity 2/2155 48/18639 0.0416666666666667 0.36038283062645 0.980130316861596 0.999999999587607 GO:0160041 neuropeptide activity 1/2155 32/18639 0.03125 0.270287122969838 0.980458079986812 0.999999999587607 GO:0015079 potassium ion transmembrane transporter activity 11/2155 160/18639 0.06875 0.594631670533643 0.98236280318944 0.999999999587607 GO:0015370 solute:sodium symporter activity 4/2155 79/18639 0.0506329113924051 0.437933566330876 0.985493716465902 0.999999999587607 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 2/2155 52/18639 0.0384615384615385 0.332661074424416 0.986986461793535 0.999999999587607 GO:0004252 serine-type endopeptidase activity 12/2155 176/18639 0.0681818181818182 0.589717359206918 0.986998206076071 0.999999999587607 GO:0016798 hydrolase activity, acting on glycosyl bonds 8/2155 130/18639 0.0615384615384615 0.532257719079065 0.987057327369983 0.999999999587607 GO:0004033 aldo-keto reductase (NADPH) activity 1/2155 36/18639 0.0277777777777778 0.240255220417633 0.98805686729402 0.999999999587607 GO:0004190 aspartic-type endopeptidase activity 1/2155 36/18639 0.0277777777777778 0.240255220417633 0.98805686729402 0.999999999587607 GO:0015399 primary active transmembrane transporter activity 11/2155 166/18639 0.0662650602409639 0.573138959550499 0.988066761368585 0.999999999587607 GO:0008146 sulfotransferase activity 2/2155 53/18639 0.0377358490566038 0.326384450378672 0.988301695531293 0.999999999587607 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 3/2155 68/18639 0.0441176470588235 0.3815818206633 0.988619748588035 0.999999999587607 GO:0022829 wide pore channel activity 1/2155 37/18639 0.027027027027027 0.233761836082022 0.989440378070851 0.999999999587607 GO:0023023 MHC protein complex binding 1/2155 37/18639 0.027027027027027 0.233761836082022 0.989440378070851 0.999999999587607 GO:0070001 aspartic-type peptidase activity 1/2155 37/18639 0.027027027027027 0.233761836082022 0.989440378070851 0.999999999587607 GO:0015293 symporter activity 9/2155 146/18639 0.0616438356164384 0.533169119282967 0.990420729366508 0.999999999587607 GO:0008028 monocarboxylic acid transmembrane transporter activity 3/2155 70/18639 0.0428571428571429 0.370679482930063 0.990631399348265 0.999999999587607 GO:0005267 potassium channel activity 7/2155 124/18639 0.0564516129032258 0.488260609235836 0.991824406498889 0.999999999587607 GO:0015144 carbohydrate transmembrane transporter activity 1/2155 40/18639 0.025 0.21622969837587 0.992701722903154 0.999999999587607 GO:0008081 phosphoric diester hydrolase activity 4/2155 87/18639 0.0459770114942529 0.397663813105048 0.992959705460257 0.999999999587607 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 2/2155 58/18639 0.0344827586206897 0.298247859828786 0.993160616910921 0.999999999587607 GO:0008227 G protein-coupled amine receptor activity 1/2155 41/18639 0.024390243902439 0.210955803293532 0.993547348320849 0.999999999587607 GO:0005253 monoatomic anion channel activity 5/2155 103/18639 0.0485436893203883 0.419863491991981 0.99438146647141 0.999999999587607 GO:0022843 voltage-gated monoatomic cation channel activity 8/2155 143/18639 0.0559440559440559 0.483870653708241 0.995121734296007 0.999999999587607 GO:0008009 chemokine activity 1/2155 45/18639 0.0222222222222222 0.192204176334107 0.996057432744378 0.999999999587607 GO:0099094 ligand-gated monoatomic cation channel activity 7/2155 136/18639 0.0514705882352941 0.44517879077385 0.996869068998153 0.999999999587607 GO:0022832 voltage-gated channel activity 10/2155 175/18639 0.0571428571428571 0.494239310573417 0.99723086387555 0.999999999587607 GO:0030246 carbohydrate binding 19/2155 280/18639 0.0678571428571429 0.586909181305933 0.997329499317806 0.999999999587607 GO:0015103 inorganic anion transmembrane transporter activity 9/2155 165/18639 0.0545454545454545 0.471773887365535 0.997675186443303 0.999999999587607 GO:0015294 solute:monoatomic cation symporter activity 5/2155 116/18639 0.0431034482758621 0.372809824785983 0.998241276205201 0.999999999587607 GO:0022853 active monoatomic ion transmembrane transporter activity 5/2155 118/18639 0.0423728813559322 0.36649101419639 0.998535201773864 0.999999999587607 GO:0005244 voltage-gated monoatomic ion channel activity 9/2155 173/18639 0.0520231213872832 0.449957753845741 0.998757245808022 0.999999999587607 GO:0008509 monoatomic anion transmembrane transporter activity 7/2155 149/18639 0.0469798657718121 0.406337688223112 0.998943844887394 0.999999999587607 GO:0008528 G protein-coupled peptide receptor activity 5/2155 122/18639 0.040983606557377 0.354474915370279 0.998986972940385 0.999999999587607 GO:0001653 peptide receptor activity 5/2155 128/18639 0.0390625 0.337858903712297 0.99942153268372 0.999999999587607 GO:0005254 chloride channel activity 2/2155 83/18639 0.0240963855421687 0.208414167109272 0.99956703458522 0.999999999587607 GO:0003823 antigen binding 8/2155 174/18639 0.0459770114942529 0.397663813105048 0.99960810572412 0.999999999587607 GO:0015108 chloride transmembrane transporter activity 4/2155 121/18639 0.0330578512396694 0.285923568100324 0.99973452997969 0.999999999587607 GO:0005261 monoatomic cation channel activity 21/2155 341/18639 0.06158357771261 0.532647937348184 0.999763919577868 0.999999999587607 GO:0022834 ligand-gated channel activity 8/2155 188/18639 0.0425531914893617 0.368050550427013 0.9998832973007 0.999999999587607 GO:0009055 electron transfer activity 3/2155 116/18639 0.0258620689655172 0.22368589487159 0.999918754482362 0.999999999587607 GO:0005125 cytokine activity 11/2155 234/18639 0.047008547008547 0.406585757629841 0.999927333159998 0.999999999587607 GO:0015276 ligand-gated monoatomic ion channel activity 7/2155 186/18639 0.0376344086021505 0.32550707282389 0.999961152082185 0.999999999587607 GO:0015078 proton transmembrane transporter activity 6/2155 185/18639 0.0324324324324324 0.280514203298426 0.999989772835027 0.999999999587607 GO:0005216 monoatomic ion channel activity 26/2155 448/18639 0.0580357142857143 0.501961799801127 0.999990807182645 0.999999999587607 GO:0022836 gated channel activity 15/2155 318/18639 0.0471698113207547 0.40798056297334 0.999994415495238 0.999999999587607 GO:0045182 translation regulator activity 17/2155 356/18639 0.047752808988764 0.413023019369639 0.999997858320361 0.999999999587607 GO:0030371 translation repressor activity 11/2155 329/18639 0.033434650455927 0.28918257533551 0.999999984730708 0.999999999587607 GO:0003735 structural constituent of ribosome 1/2155 175/18639 0.00571428571428571 0.0494239310573417 0.999999999587607 0.999999999587607