category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	77/1174	233/9376	2.63927294528811	MYH11/DMD/THBS1/ACTG2/DES/TPM1/SGCD/LMOD1/SYNPO2/PDLIM3/CSRP1/ITGA7/ITGA5/MYL9/FLNC/PDLIM7/THBS2/TMOD1/MYH9/TPM2/SYNE1/PDLIM1/SDC4/PDLIM5/TPM4/DTNA/LMNA/VCL/HSPG2/DAAM1/THBS3/FHL1/ANK2/SSPN/LDB3/PDLIM2/PDLIM4/ITGA11/DIAPH3/ZYX/ITGB3/ITGAV/COMP/ITGB1/DAAM2/TLN2/COL4A2/COL6A3/ITGA8/FHL3/FHL2/FMN2/COL6A2/COL4A1/NID1/ITGB8/SNTA1/ENO2/TMOD2/SPTBN4/SNTB2/CSRP2/THBS4/ATP1A1/CAPN3/XIRP1/COL5A2/ATP1B2/COL5A1/INF2/PLEC/BGN/DIAPH1/COL4A6/TLN1/COL24A1/AMPD3	9.58616005968653
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	60/1174	203/9376	2.36050385612742	TNC/THBS1/LAMA3/ACTN1/ITGA7/ITGA5/AKT3/MYL9/THBS2/FLNA/PPP1R12B/MYLK/VCL/PARVA/BCL2/THBS3/EMP1/CAPN2/PPP1R12C/EGFR/LAMB1/ITGA11/MAPK10/ZYX/ITGB3/PDGFD/ITGAV/COMP/ITGB1/VEGFA/TLN2/PDGFA/PIP5K1A/COL4A2/COL6A3/ITGA8/ACTN4/LAMA4/PAK3/COL6A2/PIP5K1C/IGF1R/PTK2/FLNB/COL4A1/ITGB8/PPP1R12A/RAP1B/MAP2K1/RELN/EMP2/MAPK1/THBS4/PIK3CB/PDGFRB/DIAPH1/LAMB3/COL4A6/TLN1/ELK1	7.41398842125215
NA	NA	hsa04518	Integrin signaling	46/1174	154/9376	2.38553950308635	TNC/THBS1/LAMA3/ACTN1/ITGA7/ITGA5/AKT3/THBS2/FLNA/VCL/PARVA/THBS3/EGFR/LAMB1/ITGA11/ITGB3/PDGFD/ITGAV/COMP/ITGB1/VEGFA/TLN2/NPNT/PDGFA/COL4A2/LIMS1/COL6A3/ITGA8/FERMT2/LIMS2/ACTN4/LAMA4/COL6A2/IGF1R/ITGAE/PTK2/FLNB/COL4A1/ITGB8/RELN/THBS4/PIK3CB/PDGFRB/LAMB3/COL4A6/TLN1	6.55883216950157
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	44/1174	166/9376	2.11686952238255	CACNA1C/CREB5/ATP2B4/KCNMA1/AKT3/MYL9/ADRA2C/MYLK/PLN/EDNRA/NFATC1/INSR/KCNMB1/CREB3L2/ADCY5/ADCY1/MEF2D/KCNJ8/IRS2/NFATC4/PRKG1/ADCY6/SLC8A2/PPP1R12A/ADRA2A/ITPR1/MAP2K1/NPPA/PPP3CC/MAPK1/ATP1A1/ATP1B2/PRKCE/MEF2B/GNA12/SLC25A4/ADRA1B/ADRA2B/SRF/PPIF/PPP3CB/BDKRB2/ADCY2/KNG1	5.49270750738276
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	33/1174	109/9376	2.4178922526296	FOXO1/CREB5/AKT3/INSR/CREB3L2/GFPT2/MAPK10/PYGB/PRKAB2/GYS1/PTPN1/PRKAG2/STAT3/IRS2/PTPN11/ACACB/PYGM/SLC2A4/PPARGC1A/PPP1R3B/MLXIP/SREBF1/PPARGC1B/AGT/RELA/PRKAG1/PIK3CB/NR1H2/PRKCE/SLC27A5/RPS6KA6/PRKAA2/SLC27A1	5.63309014459085
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	16/1174	34/9376	3.75829241406955	RORA/BHLHE40/RORB/PER2/PRKAB2/NFIL3/NPAS2/PRKAG2/CRY1/PER1/CRY2/NR1D1/NR1D2/PRKAG1/PER3/PRKAA2	6.09564457538016
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	35/1174	122/9376	2.29117211718379	FOXO1/CREB5/AKT3/TBC1D1/INSR/CREB3L2/PFKFB3/PPP2R3A/CAB39L/PRKAB2/PPP2R1B/PFKP/GYS1/PRKAG2/CPT1C/IRS2/ACACB/SLC2A4/IGF1R/PPARGC1A/RPTOR/PPP2R2C/SREBF1/ULK1/ADIPOR2/PPP2R2D/PPP2CA/PFKM/PRKAG1/CAMKK2/PIK3CB/FOXO3/PRKAA2/PPP2R5B/CAB39	5.43074124627702
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	28/1174	89/9376	2.51256627682178	TNC/THBS1/LAMA3/CD44/ITGA7/ITGA5/THBS2/SDC4/HSPG2/THBS3/LAMB1/ITGA11/ITGB3/ITGAV/COMP/ITGB1/NPNT/COL4A2/COL6A3/ITGA8/LAMA4/COL6A2/COL4A1/ITGB8/RELN/THBS4/LAMB3/COL4A6	5.42414759081844
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	30/1174	99/9376	2.42011253936297	CACNB2/DMD/DES/TPM1/SGCD/ITGA7/CACNA1C/ITGA5/TPM2/TPM4/DTNA/LMNA/SSPN/ITGA11/ITGB3/ITGAV/ITGB1/PRKAB2/ITGA8/PRKAG2/CACNA2D1/CACNG4/SLC8A2/ITGB8/SNTA1/SNTB2/AGT/PRKAG1/PRKAA2/TGFB2	5.37398420169927
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	41/1174	157/9376	2.08561290812617	SERPINE1/BMP8A/BMPR1A/TCF7L2/TGFBR1/BMP8B/YAP1/PARD3/MYC/FRMD6/CCN2/DLG2/TCF7L1/PPP2R1B/SMAD3/TEAD4/DLG5/YWHAG/TEAD3/RASSF1/STK3/TEAD1/FZD3/WTIP/BMPR1B/WNT5A/CTNNA1/SMAD7/PPP2R2C/WNT5B/FZD8/TEAD2/BBC3/FZD10/PPP2R2D/PPP2CA/NKD1/GLI2/BMP2/LATS2/TGFB2	5.18970559271593
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	31/1174	105/9376	2.35788107406506	CACNB2/DMD/DES/TPM1/SGCD/ITGA7/CACNA1C/ITGA5/TPM2/PLN/TPM4/DTNA/LMNA/SSPN/ITGA11/ADCY5/ITGB3/ADCY1/ITGAV/ITGB1/ITGA8/CACNA2D1/ADCY6/CACNG4/SLC8A2/ITGB8/SNTA1/SNTB2/AGT/TGFB2/ADCY2	5.29362165707431
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	49/1174	204/9376	1.918295086348	THBS1/CD44/TIMP3/ITGA5/AKT3/FLNA/PPP1R12B/ESR1/PLCE1/SDC4/HOXD10/HSPG2/ANK2/PPP1R12C/CDKN1A/EGFR/MRAS/ITGB3/TWIST2/ITGAV/ITGB1/VEGFA/PLCG2/MYC/RRAS2/CAMK2D/CTTN/GPC1/STAT3/HSPB2/PTPN11/IGF1R/CAMK2G/PTK2/FZD3/PPP1R12A/ITPR1/WNT5A/MAP2K1/WNT5B/FGF2/MAPK1/FZD8/FZD10/PIK3CB/CBL/TGFB2/SLC9A1/ELK1	5.01678079639571
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	75/1174	362/9376	1.65463495439871	TNC/THBS1/LAMA3/ITGA7/ITGA5/CREB5/AKT3/THBS2/NR4A1/NGF/IL6R/BCL2/INSR/THBS3/F2R/CREB3L2/MAGI2/CDKN1A/EGFR/OSMR/LAMB1/ITGA11/PPP2R3A/ITGB3/NTRK2/PDGFD/CSF3/ITGAV/COMP/ITGB1/VEGFA/PDGFA/MYC/GNB5/COL4A2/PPP2R1B/COL6A3/GNG12/GYS1/ITGA8/YWHAG/FGF7/LAMA4/PHLPP2/COL6A2/IGF1R/ANGPT2/PTK2/ANGPT4/COL4A1/ITGB8/IL4R/RPTOR/MAP2K1/RELN/MCL1/PPP2R2C/DDIT4/FLT3LG/FGF2/MAPK1/THBS4/NTRK1/PPP2R2D/RELA/PPP2CA/GNG4/PIK3CB/JAK1/PDGFRB/FOXO3/LAMB3/COL4A6/PRKAA2/PPP2R5B	4.80567617961972
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	31/1174	110/9376	2.25070466160756	SERPINE1/AKT3/IL6R/BCL2/INSR/CDKN1A/PFKFB3/EGFR/TF/VEGFA/PLCG2/PFKP/CAMK2D/STAT3/HK1/IGF1R/CAMK2G/ANGPT2/ANGPT4/HK2/ENO2/MAP2K1/ALDOA/NPPA/MAPK1/ALDOB/TIMP1/RELA/PFKM/PIK3CB/LDHA	4.99188724818092
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	27/1174	90/9376	2.39591141396934	FOXO1/CREB5/AKT3/INSR/CREB3L2/ADCY5/ADCY1/PRKAB2/PRKAG2/IRS2/SOD2/IGF1R/ADCY6/ATG101/PPARGC1A/RPTOR/ULK1/ADIPOR2/RELA/PRKAG1/CAMKK2/PIK3CB/FOXO3/SESN2/EHMT1/PRKAA2/ADCY2	5.03413175199533
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	30/1174	110/9376	2.17810128542667	THBS1/INHBA/LTBP1/BMP8A/BMPR1A/NBL1/TGFBR1/TF/BMP8B/MYC/THSD4/PPP2R1B/RGMA/ID4/ACVR1/SMAD3/NEO1/SMURF1/SKI/CHRD/BMPR1B/SMAD7/LRRC32/ACVR1B/MAPK1/ZFYVE9/PPP2CA/BMP2/TGFB2/LEMD3	4.70210831086855
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	38/1174	154/9376	1.97066306776699	CACNB2/CACNA1C/OXTR/MYL9/PPP1R12B/MYLK/NFATC1/GNAO1/PPP1R12C/CDKN1A/EGFR/ADCY5/RYR3/ADCY1/PRKAB2/CAMK2D/PRKAG2/PLA2G4C/NFATC4/CACNA2D1/ADCY6/CAMK2G/CACNG4/CAMK1/CAMK1D/PPP1R12A/ITPR1/MAP2K1/NPPA/PPP3CC/RCAN1/MAPK1/PRKAG1/CAMKK2/PPP3CB/PRKAA2/ADCY2/ELK1	4.59490049936195
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	55/1174	254/9376	1.72933238541094	PTGER3/CACNA1C/OXTR/ATP2B4/PDE1A/CACNA1H/MYLK/PLN/PLCE1/AVPR1A/EDNRA/NFATC1/NGF/ITPKC/F2R/STIM1/SPHK1/EGFR/RYR3/NTRK2/PDGFD/ADCY1/VEGFA/NTRK3/PDGFA/PLCG2/CAMK2D/HRC/FGF7/MCU/CASQ2/NFATC4/CAMK2G/HTR2A/CAMK1/SLC8A2/CAMK1D/ITPR1/GRIN2A/PDE1B/ASPH/ITPKB/PPP3CC/FGF2/NTRK1/TPCN2/LHCGR/PDGFRB/SLC25A4/ADRA1B/GNAL/PPIF/PPP3CB/BDKRB2/ADCY2	4.45817515258612
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	25/1174	86/9376	2.32161958717959	CACNB2/DMD/DES/SGCD/ITGA7/CACNA1C/ITGA5/DTNA/LMNA/TCF7L2/SSPN/ITGA11/ITGB3/ITGAV/ITGB1/TCF7L1/ITGA8/CACNA2D1/CACNG4/SLC8A2/ITGB8/SNTA1/CTNNA1/SNTB2/CDH2	4.65808746818877
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	35/1174	140/9376	1.99659284497445	SERPINE1/ACTA2/AKT3/MYLK/HDAC4/SPHK1/TGFBR1/MRAS/ADCY5/RYR3/ADCY1/PRKAB2/MAP1LC3A/GNB5/CCN2/RRAS2/GNG12/SMAD3/PRKAG2/MEF2D/ADCY6/PPARGC1A/SLC8A2/ITPR1/MAP2K1/NOTCH3/MAPK1/BECN1/PRKAG1/GNG4/PRKCE/MEF2B/PRKAA2/ADCY2/SLC9A1	4.49468876881662
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	67/1174	333/9376	1.60686751487433	TNC/THBS1/LAMA3/FOXO1/ITGA7/ITGA5/CREB5/AKT3/THBS2/THBS3/TCF7L2/CREB3L2/CDKN1A/EGFR/LAMB1/ITGA11/PPP2R3A/ITGB3/ITGAV/COMP/ITGB1/VEGFA/PARD3/COL4A2/DLG2/TCF7L1/PPP2R1B/COL6A3/ITGA8/LAMA4/COL6A2/TRAF3/PTK2/FZD3/COL4A1/ITGB8/HES4/WNT5A/PKM/MAP2K1/RELN/HES6/TUBG2/PPP2R2C/NOTCH3/WNT5B/MAPK1/CSNK1A1/FZD8/THBS4/UBR4/IRF1/FZD10/PPP2R2D/RELA/PPP2CA/PIK3CB/HLA-F/ATP6V0A1/JAK1/PDGFRB/TICAM1/LAMB3/COL4A6/PPP2R5B/HEYL/ATP6V0A2	4.26598718201955
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	50/1174	232/9376	1.72120072842625	MYH11/ACTN1/ITGA7/ITGA5/AKT3/MYL9/ENAH/PPP1R12B/MYH9/MYLK/VCL/GSN/F2R/PPP1R12C/EGFR/ARHGEF7/MRAS/ITGA11/DIAPH3/ITGB3/PDGFD/ITGAV/ITGB1/PDGFA/PIP5K1A/RRAS2/GNG12/CXCL12/ITGA8/FGF7/ACTN4/PAK3/PIP5K1C/WASF1/ITGAE/PTK2/ITGB8/PPP1R12A/SSH1/MAP2K1/FGF2/MAPK1/PIK3CB/PDGFRB/GNA12/DIAPH1/BDKRB2/NCKAP1/SLC9A1/KNG1	4.2081561309066
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	61/1174	300/9376	1.62389551391255	CACNB2/CACNA1C/AKT3/NR4A1/FLNA/CACNA1H/NFATC1/NGF/HSPB1/INSR/RELB/EGFR/MAPKAPK2/TGFBR1/MRAS/DUSP16/MAPK10/MAP3K5/DUSP5/NTRK2/PDGFD/VEGFA/PDGFA/MYC/RASGRP2/RRAS2/GNG12/IL1RAP/DDIT3/PLA2G4C/FGF7/CACNA2D1/IGF1R/MAP2K3/STK3/CACNG4/MAP3K10/ANGPT2/ANGPT4/MAP3K13/HSPA1B/DUSP8/MAP3K14/RAP1B/MAP2K1/ECSIT/PPP3CC/MAP3K4/FLT3LG/FGF2/MAPK1/NTRK1/RELA/PDGFRB/GNA12/RPS6KA6/SRF/IL1R1/PPP3CB/TGFB2/ELK1	4.15513416055883
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	19/1174	62/9376	2.44743639061384	FOXO1/AKT3/INSR/CRYAB/ADCY5/ADCY1/PRKAB2/PRKAG2/IRS2/SOD2/IGF1R/ADCY6/HSPA1B/RPTOR/PRKAG1/PIK3CB/FOXO3/PRKAA2/ADCY2	4.32600502270109
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	33/1174	138/9376	1.90978446041034	SORBS1/FOXO1/AKT3/RHOQ/INSR/MAPK10/PYGB/PRKAB2/GYS1/PTPN1/CBLB/PRKAG2/IRS2/HK1/ACACB/PYGM/SLC2A4/PPARGC1A/PPP1R3B/HK2/RPTOR/MAP2K1/PRKAR1B/MAPK1/SREBF1/PRKAR2A/PRKAG1/PIK3CB/PRKAR2B/PRKAA2/CBL/PPP1R3F/ELK1	4.07332331468562
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	32/1174	134/9376	1.90719316534872	MYH11/ACTG2/CALD1/CACNA1C/ACTA2/KCNMA1/MYL9/PPP1R12B/MYH9/RAMP1/MYLK/AVPR1A/EDNRA/KCNMB1/PPP1R12C/ADCY5/ADCY1/PTGIR/PLA2G4C/PRKG1/ADCY6/PPP1R12A/ITPR1/MAP2K1/NPPA/MAPK1/AGT/PLA2G6/PRKCE/GNA12/ADRA1B/ADCY2	4.00155684670917
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	26/1174	101/9376	2.05589758294398	SERPINE1/FOXO1/AKT3/PLCE1/NFATC1/BCL2/TGFBR1/MAPK10/CCL2/VEGFA/PLCG2/COL4A2/SMAD3/STAT3/PIM1/STAT5B/COL4A1/MAPK1/AGT/RELA/PIK3CB/PRKCE/DIAPH1/STAT5A/COL4A6/TGFB2	4.03631756320054
Cellular Processes	Cell motility	hsa04814	Motor proteins	41/1174	194/9376	1.68784137410211	MYH11/ACTG2/TPM1/ACTA2/MYL9/MYO1D/MYH9/TPM2/TPM4/DYNC1I1/MYO9B/MYO1E/TUBB6/KLC1/TUBB3/KIF21A/KIF13A/DNAH7/HOOK3/DYNC2LI1/KIF5C/KIF9/KIF16B/MYO6/KIFC2/DYNC1H1/DCTN2/TUBG2/KIF13B/KIFC3/DYNLRB2/DNAL1/KIFAP3/DYNC2H1/DYNC1LI1/KLC2/TUBA4A/DNALI1/KIF3A/DYNC1I2/DYNLT3	3.66252265955867
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	39/1174	184/9376	1.69276349900007	TRPC4/MYL9/ENAH/SLIT3/EPHB6/SEMA3C/BOC/ITGB1/PARD3/PLCG2/PLXNA4/NTN4/RGMA/CAMK2D/CXCL12/ABLIM2/NEO1/SEMA5A/SEMA4A/NFATC4/PAK3/PTPN11/CAMK2G/PTK2/FZD3/NTN1/SSH1/ABL1/BMPR1B/WNT5A/PPP3CC/WNT5B/MAPK1/TRPC1/PLXNB1/PIK3CB/EPHB1/PPP3CB/SRGAP1	3.59044852619473
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	24/1174	97/9376	1.97600941358296	CACNA1C/CACNA1H/GNAO1/ADCY5/PER2/RYR3/ADCY1/GNB5/GNG12/CAMK2D/RASD1/GRIA1/PRKG1/ADCY6/CAMK2G/PER1/ITPR1/GRIN2A/GRIA3/MAPK1/GNG4/PER3/ADCY2/NOS1AP	3.65551937752838
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	12/1174	36/9376	2.66212379329926	GBE1/PYGB/GPI/GYS1/HK1/PYGM/PGM2L1/HK2/GYG1/UGP2/PGM2/GANC	3.78007992825752
Organismal Systems	Digestive system	hsa04978	Mineral absorption	17/1174	61/9376	2.22571005669283	ATP2B4/MT1G/MT1M/MT1A/MT1X/MT1F/MT2A/HEPH/SLC30A1/MT1E/TF/MT1H/CYBRD1/SLC8A2/STEAP2/ATP1A1/ATP1B2	3.63346550487593
NA	NA	hsa04517	IgSF CAM signaling	56/1174	299/9376	1.49577524171999	MYH11/SORBS1/FOXO1/ACTN1/ITGA5/AKT3/MYL9/TRIO/SLIT3/NLGN1/MYH9/MYLK/VCL/NCAM1/TUBB6/ANK2/MAGI2/NFASC/PPFIA2/SCN8A/MAPK10/ITGB3/TUBB3/PTPRS/ITGB1/NTRK3/PARD3/PLCG2/TJP2/PLXNA4/PVR/KCNQ3/IL1RAP/ACTN4/PAK3/SLITRK4/PTPN11/MAP2/CNTNAP1/PTK2/NTN1/ABL1/NLGN2/RAP1B/SPTBN4/MAP2K1/MAPK1/SLITRK2/CDH2/PPFIA1/PIK3CB/ERC1/MTSS2/TUBA4A/CADM4/SRGAP1	3.29616592604121
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	33/1174	154/9376	1.71136529569238	CACNB2/TPM1/CACNA1C/CREB5/ATP2B4/AKT3/TPM2/PLN/TPM4/BCL2/CREB3L2/ADCY5/PPP2R3A/ADCY1/PPP2R1B/CAMK2D/CACNA2D1/ADCY6/CAMK2G/CACNG4/SLC8A2/PPP2R2C/MAPK1/AGT/SCN4B/ATP1A1/ATP1B2/PPP2R2D/PPP2CA/ADRA1B/PPP2R5B/ADCY2/SLC9A1	3.36744320552469
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	25/1174	107/9376	1.86597462147145	FOXO1/CREB5/AKT3/CREB3L2/PYGB/PRKAB2/PFKP/SIK2/GYS1/CAMK2D/PRKAG2/CPT1C/ACACB/PYGM/CAMK2G/PPARGC1A/ITPR1/PKM/PPP3CC/PFKM/PRKAG1/LDHA/PPP3CB/PRKAA2/ADCY2	3.4083204204107
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	33/1174	157/9376	1.67866404800399	SERPINE1/FOXO1/AKT3/NFATC1/CAPN2/CDKN1A/MAPKAPK2/TGFBR1/MRAS/MYC/RAD9A/RRAS2/SMAD3/HIPK2/MCU/NFATC4/MAP2K3/HIPK3/TRAF3IP2/ITPR1/MAP2K1/PPP3CC/E2F3/MAPK1/ZFP36L2/RELA/NBN/PIK3CB/HLA-F/SLC25A4/FOXO3/PPP3CB/TGFB2	3.24431165025555
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	23/1174	98/9376	1.8743524667107	CACNA1C/CREB5/ATP2B4/NR4A1/CACNA1H/CREB3L2/ADCY5/ADCY1/LDLR/PRKD1/CAMK2D/ADCY6/CAMK2G/CAMK1/CAMK1D/DAGLB/ITPR1/NPPA/AGT/ATP1A1/ATP1B2/PRKCE/ADCY2	3.29179057577502
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	10/1174	29/9376	2.753921165482	YAP1/FRMD6/TEAD4/TEAD3/RASSF1/STK3/TEAD1/WTIP/TEAD2/LATS2	3.57876145196716
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	43/1174	224/9376	1.53309807739109	CREB5/FOSL1/AKT3/NFATC1/RELB/CREB3L2/IL15/CDKN1A/TGFBR1/ADCY5/MAPK10/ADCY1/TLN2/MYC/SMAD3/CDKN2C/NFATC4/ADCY6/CRTC3/STAT5B/HLA-DRB1/MAP3K14/MAP2K1/PPP3CC/E2F3/MAPK1/CRTC1/RELA/PIK3CB/HLA-F/JAK1/ANAPC7/SLC25A4/SRF/STAT5A/TLN1/IL1R1/PPP3CB/ZFP36/TGFB2/ADCY2/MMP7/ELK1	3.05515271563564
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	32/1174	155/9376	1.64879925262406	PBX1/CACNA1C/CREB5/NR4A1/CACNA1H/TCF7L2/CREB3L2/CDKN1A/EGFR/ADCY5/ADCY1/LDLR/TCF7L1/CAMK2D/PDE8A/CDKN2C/RASD1/ADCY6/CAMK2G/FZD3/RAP1B/ITPR1/WNT5A/MAP2K1/E2F3/WNT5B/MAPK1/AGT/FZD8/FZD10/CRH/ADCY2	3.08139223039667
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	34/1174	169/9376	1.60672560305636	AKT3/BCL2/VMP1/MRAS/MAPK10/ERN1/MAP1LC3A/RRAS2/DEPTOR/IRS2/DAPK3/EIF2AK3/IGF1R/ATG101/ZFYVE1/RUBCN/RPTOR/ITPR1/MAP2K1/GABARAPL1/DDIT4/MAPK1/BECN1/ULK1/WDR45/PPP2CA/CAMKK2/AMBRA1/PIK3CB/WDR41/CALCOCO2/TP53INP2/PRKAA2/PLEKHM1	3.01117784861975
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	32/1174	157/9376	1.62779544048872	THBS1/PBX1/MFGE8/NFATC1/SLC16A1/AXL/SPHK1/MAPKAPK2/DUSP16/DUSP5/ITGB3/ITGAV/PANX1/ANO6/CAMK2D/CPT1C/NFATC4/XKR6/PTPN11/CAMK2G/PTK2/ATP11C/DUSP8/ANO4/ANO3/MAP2K1/ADAM17/MAPK1/PLA2G6/NR1H2/TMEM30A/ODC1	3.00113740744801
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	28/1174	133/9376	1.68134134313638	CACNA1C/MAOB/CREB5/AKT3/GNAO1/CREB3L2/ADCY5/MAPK10/PPP2R3A/GNB5/PPP2R1B/GNG12/CAMK2D/GRIA1/KIF5C/CAMK2G/ITPR1/GRIN2A/GRIA3/PPP3CC/PPP2R2C/PPP2R2D/PPP2CA/GNG4/GNAL/PPP3CB/PPP2R5B/LRTOMT	2.99394550009615
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	20/1174	86/9376	1.85729566974367	AKT3/CDKN1A/ABL2/EGFR/MAPK10/PLCG2/MYC/CAMK2D/CBLB/PAK3/CAMK2G/PTK2/STAT5B/ABL1/MAP2K1/MAPK1/PIK3CB/STAT5A/CBL/ELK1	3.02156403741529
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	35/1174	178/9376	1.57035392301361	FOSL1/TLE2/NFATC1/ROR2/DAAM1/TCF7L2/MAPK10/DAAM2/MYC/CCN4/TCF7L1/CAMK2D/SMAD3/PRICKLE2/TBL1X/ROR1/NFATC4/CTBP2/DKK1/CAMK2G/TLE1/FZD3/MCC/CELSR2/WNT5A/TLE6/APCDD1/PPP3CC/WNT5B/CSNK1A1/FZD8/FZD10/NKD1/PPP3CB/MMP7	2.90648131794652
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	21/1174	93/9376	1.80337418255756	LAMA3/AKT3/BCL2/CDKN1A/LAMB1/ITGAV/ITGB1/MYC/TRAF5/COL4A2/LAMA4/TRAF3/PTK2/COL4A1/TRAF1/E2F3/RELA/ZBTB17/PIK3CB/LAMB3/COL4A6	2.94560815995862
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	23/1174	105/9376	1.74939563559666	AKT3/NFATC1/RELB/MAPKAPK2/MRAS/MAPK10/PLCG2/PLK3/RRAS2/CBLB/BCL3/NFATC4/PTPN11/EGR3/MAP3K14/ITPR1/IL17D/PPP3CC/MAPK1/IRF1/RELA/PIK3CB/PPP3CB	2.92147599821497
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	17/1174	70/9376	1.93954733511803	AKT3/MAPK10/ACSL4/PRKAB2/PRKAG2/STAT3/CPT1C/IRS2/PTPN11/ACACB/SLC2A4/PPARGC1A/ADIPOR2/RELA/PRKAG1/CAMKK2/PRKAA2	2.98501120130965
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	17/1174	71/9376	1.91222976701778	AKT3/SLC7A5/EGFR/GLS/NTRK3/MYC/PFKP/HK1/HK2/PKM/MAP2K1/MAPK1/NTRK1/PFKM/PIK3CB/LDHA/PDGFRB	2.91900628061061
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	29/1174	144/9376	1.60836645845164	FOXO1/AKT3/TCF7L2/MAPK10/MAP3K5/ADH1B/PRKAB2/TCF7L1/PRKAG2/CPT1C/ACACB/MAP2K3/TRAF3/PPARGC1A/ALDH1B1/MAP3K14/LPIN1/SREBF1/ADIPOR2/RELA/PRKAG1/CAMKK2/LPIN3/ALDH2/FOXO3/ADH5/TICAM1/C5AR1/PRKAA2	2.78328971046366
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	27/1174	133/9376	1.62129343802436	FOXO1/AKT3/BCL6/FBXO32/HOMER1/INSR/CDKN1A/EGFR/TGFBR1/MAPK10/PRKAB2/PLK3/SMAD3/PRKAG2/STAT3/IRS2/SOD2/SLC2A4/IGF1R/MAP2K1/GABARAPL1/MAPK1/PRKAG1/PIK3CB/FOXO3/PRKAA2/TGFB2	2.73008340349602
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	18/1174	80/9376	1.796933560477	AKT3/IL6R/BCL2/AXL/EGFR/PDGFD/VEGFA/PDGFA/PLCG2/STAT3/IGF1R/MAP2K1/FGF2/MAPK1/PIK3CB/JAK1/PDGFRB/FOXO3	2.70818829297451
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	21/1174	99/9376	1.69407877755408	NGF/ADCY5/MAPK10/ADCY1/PLCG2/CAMK2D/IL1RAP/PLA2G4C/MAP2K3/ADCY6/CAMK2G/HTR2A/ITPR1/NTRK1/PLA2G6/PIK3CB/PRKCE/IL1R1/BDKRB2/ADCY2/KNG1	2.62653013893078
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	20/1174	93/9376	1.71749922148339	SORBS1/ACTN1/MYL9/VCL/INSR/TCF7L2/EGFR/TGFBR1/PARD3/TCF7L1/SMAD3/WASF3/PTPN1/ACTN4/SMURF1/WASF1/IGF1R/RAP1B/CTNNA1/MAPK1	2.63074369011604
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	28/1174	144/9376	1.55290554609124	RORA/AKT3/KCND3/MAPK10/MAP3K5/ERN1/MCU/GRIA1/ATG101/ITPR1/GRIN2A/RELN/DAB1/GRIA3/BECN1/PSMD2/ULK1/ATXN1/AFG3L2/AMBRA1/PIK3CB/FGF14/PSMD1/SLC25A4/ATXN2/PPIF/PSMD11/BEAN1	2.52955483642326
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	7/1174	21/9376	2.66212379329926	XYLT1/CHSY3/CHST15/CHST7/UST/CHST3/DSEL	2.88476820066053
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	25/1174	125/9376	1.59727427597956	AKT3/SGMS2/BCL2/CERS6/SPHK1/MAPK10/MAP3K5/PPP2R3A/CERS4/PPP2R1B/S1PR3/ABCC1/MAP2K1/PPP2R2C/MAPK1/PPP2R2D/RELA/PPP2CA/CERS5/PIK3CB/PRKCE/GNA12/PPP2R5B/BDKRB2/KNG1	2.54328061295421
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	44/1174	250/9376	1.40560136286201	WIPF3/EGFR/RAB31/TGFBR1/ASAP2/PARD3/PIP5K1A/LDLR/EHD2/SMAD3/CBLB/ARFGAP3/AMPH/EHD1/SMURF1/SPART/CLTCL1/PIP5K1C/KIF5C/IGF1R/PSD/EEA1/GRK4/RAB11FIP5/ASAP1/EPN2/CLTB/HSPA1B/AGAP1/ITCH/RUFY2/ACAP3/ZFYVE9/HLA-F/AP2A1/VPS37C/RAB11FIP3/SNX1/DNM3/IGF2R/VPS45/CBL/ASAP3/ARFGAP1	2.45917243356818
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	24/1174	119/9376	1.61069674888695	CREB5/AKT3/DAB2IP/CREB3L2/IL15/MAPK10/MAP3K5/CCL2/TRAF5/BCL3/LIF/MAP2K3/TRAF3/TNFAIP3/TRAF1/MAP3K14/MAP2K1/ADAM17/ITCH/MAPK1/IRF1/RELA/PIK3CB/DNM1L	2.53643513816956
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	42/1174	238/9376	1.40935965527608	AKT3/RASAL2/PLCE1/NGF/INSR/ABL2/EGFR/MRAS/MAPK10/NTRK2/PDGFD/VEGFA/PDGFA/PLCG2/RASGRP2/GNB5/RRAS2/GNG12/SYNGAP1/PLA2G4C/FGF7/PAK3/PTPN11/IGF1R/RASSF1/ANGPT2/ANGPT4/RALGAPA1/ABL1/RAP1B/GRIN2A/MAP2K1/FLT3LG/FGF2/MAPK1/NTRK1/PLA2G6/RELA/GNG4/PIK3CB/PDGFRB/ELK1	2.42006897498236
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	18/1174	83/9376	1.73198415467663	AUTS2/PHC2/PHF1/ASXL1/CBX7/PHC3/SFMBT2/CBX6/L3MBTL1/ASXL3/FOXK1/FOXK2/RING1/EZH2/YAF2/E2F6/EZH1/TEX10	2.53409307296041
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	17/1174	77/9376	1.7632248501073	AKT3/CDKN1A/TGFBR1/MYC/SMAD3/PTPN11/CTBP2/STAT5B/ABL1/MAP2K1/E2F3/MAPK1/RELA/PIK3CB/STAT5A/CBL/TGFB2	2.54413144139977
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	10/1174	37/9376	2.15847875132373	UAP1/GFPT2/GPI/HK1/PMM2/HK2/UGP2/UGDH/PGM2/GNE	2.6711516862755
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	38/1174	212/9376	1.43151939828357	THBS1/CNR1/AKT3/ENAH/PLCE1/NGF/INSR/GNAO1/F2R/MAGI2/EGFR/MRAS/ADCY5/ITGB3/PDGFD/ADCY1/ITGB1/VEGFA/TLN2/PARD3/PDGFA/RASGRP2/PRKD1/FGF7/IGF1R/MAP2K3/ADCY6/ANGPT2/ANGPT4/RAP1B/GRIN2A/MAP2K1/FGF2/MAPK1/PIK3CB/PDGFRB/TLN1/ADCY2	2.40428262486731
NA	NA	hsa04081	Hormone signaling	39/1174	219/9376	1.42223051970782	OXTR/RAMP1/ADRA2C/ESR1/AVPR1A/BMPR1A/INSR/HEPH/GNAO1/SSTR2/ADCY5/ITGB3/ADCY1/ITGAV/GNB5/GNG12/ACVR1/STAT3/IRS2/PRKG1/IGF1R/ADCY6/STAT5B/ADRA2A/BMPR1B/DIO2/NPPA/AGT/ADIPOR2/PTHLH/GNG4/PIK3CB/LHCGR/GNA12/CRH/ADRA1B/ADRA2B/STAT5A/ADCY2	2.39196530679346
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	40/1174	226/9376	1.41351705838899	PTGER3/CACNA1C/OXTR/CREB5/ATP2B4/AKT3/MYL9/PDE10A/PLN/PLCE1/EDNRA/NFATC1/F2R/CREB3L2/SSTR2/ADCY5/MAPK10/ADCY1/GABBR1/RRAS2/CAMK2D/GRIA1/ADCY6/CAMK2G/PPP1R12A/RAP1B/GRIN2A/MAP2K1/GRIA3/NPPA/MAPK1/ATP1A1/ATP1B2/RELA/PIK3CB/NPY1R/LHCGR/CRH/ADCY2/SLC9A1	2.38065743190392
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	14/1174	60/9376	1.86348665530948	AKT3/HSPB1/SPHK1/MAPKAPK2/VEGFA/PLCG2/PLA2G4C/PTK2/MAP2K1/PPP3CC/MAPK1/PIK3CB/SH2D2A/PPP3CB	2.53849504266739
Organismal Systems	Nervous system	hsa04730	Long-term depression	14/1174	60/9376	1.86348665530948	GNAO1/PPP2R1B/PLA2G4C/GRIA1/PRKG1/IGF1R/ITPR1/MAP2K1/GNAZ/GRIA3/MAPK1/PPP2CA/GNA12/CRH	2.53849504266739
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	40/1174	227/9376	1.4072901109952	PTGER3/CREB5/AKT3/AKAP13/NFATC1/IL6R/GNAO1/CREB3L2/CDKN1A/EGFR/ADCY5/ITGB3/ADCY1/CCL2/ITGAV/VEGFA/MYC/TRAF5/GNB5/GNG12/CXCL12/STAT3/NFATC4/ADCY6/PTK2/ITPR1/MAP2K1/PPP3CC/E2F3/MAPK1/RELA/GNG4/PIK3CB/HLA-F/JAK1/GNA12/IL1R1/PPP3CB/ADCY2/ELK1	2.35011862593433
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	24/1174	122/9376	1.57108945178317	FOXO1/AKT3/ESR1/PLN/PLCE1/RCAN2/ITGB3/ITGAV/PLCG2/MYC/PFKP/MED13L/DIO2/MAP2K1/NOTCH3/RCAN1/MAPK1/MED27/ATP1A1/ATP1B2/PFKM/PIK3CB/MED13/SLC9A1	2.40203377987842
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	10/1174	38/9376	2.10167667892047	UAP1/GFPT2/GPI/HK1/PMM2/HK2/UGP2/UGDH/PGM2/GNE	2.57441658009591
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	23/1174	116/9376	1.58350467015215	CACNA1C/HOMER1/GNAO1/ADCY5/ADCY1/GLS/GNB5/GNG12/PLA2G4C/GRIA1/ADCY6/GRIK2/ITPR1/GRIK5/GRIN2A/GRIA3/PPP3CC/MAPK1/TRPC1/GNG4/NCDN/PPP3CB/ADCY2	2.39236611089619
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	15/1174	67/9376	1.78799359251443	ADH1B/GPI/PFKP/HK1/ALDH1B1/HK2/ENO2/PKM/ALDOA/ALDOB/PFKM/PGM2/LDHA/ALDH2/ADH5	2.44888491763157
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/1174	44/9376	1.99659284497445	CREB5/DYNC1I1/CREB3L2/DYNC2LI1/ADCY6/DYNC1H1/DCTN2/DYNC2H1/DYNC1LI1/DYNC1I2/NSF	2.50678185349383
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	28/1174	149/9376	1.50079462172576	AKT3/PLPP1/AVPR1A/INSR/F2R/SPHK1/EGFR/DGKI/MRAS/ADCY5/PDGFD/ADCY1/PDGFA/PLCG2/PIP5K1A/RRAS2/PLA2G4C/PTPN11/PIP5K1C/ADCY6/MAP2K1/MAPK1/AGT/PIK3CB/PDGFRB/GNA12/DNM3/ADCY2	2.3312150286947
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	13/1174	56/9376	1.85397907033341	GPR161/BCL2/BOC/SMURF1/PTCH2/EVC/EVC2/CSNK1A1/CDON/GLI2/MGRN1/KIF3A/IQCE	2.42489583993998
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	10/1174	39/9376	2.04778753330712	MTHFD2/MTHFD1L/BHMT2/DMGDH/ALDH1L2/MAT2A/AMT/FTCD/AHCY/ATIC	2.48062807810102
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	15/1174	68/9376	1.7616995690951	ZBTB16/AKT3/TCF7L2/PER2/MYC/TCF7L1/STAT3/PIM1/STAT5B/MAP2K1/MAPK1/RELA/RARA/PIK3CB/STAT5A	2.38489785587073
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	20/1174	99/9376	1.61340835957531	AKT3/PLPP1/EGFR/DGKI/MAPK10/PDGFD/PDGFA/PIP5K1A/WASF3/PLA2G4C/PIP5K1C/WASF1/MAP2K1/MAPK1/SLC22A4/PCYT1A/PIK3CB/PDGFRB/SLC44A3/CHKA	2.32125746528983
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	16/1174	75/9376	1.70375922771153	AKT3/REV3L/BCL2/CDKN1A/MGST1/MAP3K5/GSTM5/MAPK1/ERCC1/BBC3/GSTM2/PIK3CB/GSTM4/GSTT2B/MLH1/POLH	2.31499318079083
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	14/1174	63/9376	1.77474919553284	PLOD2/HADH/PRDM2/PLOD1/ALDH1B1/CAMKMT/DOT1L/KMT2C/EZH2/ACAT1/ALDH2/EHMT1/EZH1/SETMAR	2.33424486119735
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	42/1174	248/9376	1.35253063691817	AKT3/MYL9/FLNA/BCL2/DYNC1I1/TUBB6/TCF7L2/MAPK10/KLC1/TUBB3/MYC/TCF7L1/RAB9B/WASF3/AHNAK2/DYNC2LI1/PAK3/KIF5C/MAP2K3/FYCO1/MYO6/PLEKHM2/DYNC1H1/DCTN2/MAP2K1/MAPK1/SNX33/FHOD1/RELA/DYNLRB2/KPNA1/PIK3CB/STX10/DYNC2H1/AHNAK/DYNC1LI1/KLC2/TUBA4A/DYNC1I2/PLEKHM1/DYNLT3/NCKAP1	2.12860312065877
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	9/1174	35/9376	2.05363835483086	PFKFB3/PFKP/HK1/PMM2/HK2/ALDOA/ALDOB/PFKM/SORD	2.36259190644481
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	10/1174	41/9376	1.94789545851166	THBS1/CDKN1A/EGFR/VEGFA/MYC/DAPK3/RASSF1/MAP2K1/E2F3/MAPK1	2.30120343651117
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	22/1174	115/9376	1.52782756832827	CACNA1C/CREB5/AKT3/BCL2/GNAO1/CREB3L2/ADCY5/ADCY1/GNB5/GNG12/CAMK2D/KCNQ3/ADCY6/CAMK2G/ACHE/ITPR1/MAP2K1/KCNQ4/MAPK1/GNG4/PIK3CB/ADCY2	2.15462577995802
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	11/1174	47/9376	1.86915074848672	CACNA1C/INSR/MAPK10/IRS2/HK1/SLC2A4/HK2/PKM/MAPK1/PIK3CB/PRKCE	2.25988476889081
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	14/1174	65/9376	1.72014152797798	PBX1/CACNA1C/CREB5/NR4A1/CACNA1H/CREB3L2/ADCY5/ADCY1/LDLR/PDE8A/ADCY6/ITPR1/AGT/ADCY2	2.20412476910093
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	28/1174	155/9376	1.44269934604605	THBS1/ITGA5/THBS2/C1R/DYNC1I1/THBS3/TUBB6/PLA2R1/ITGB3/TUBB3/ITGAV/COMP/ITGB1/STX18/EEA1/HLA-DRB1/STX12/DYNC1H1/THBS4/SEC61A2/HLA-F/ATP6V0A1/DYNC2H1/DYNC1LI1/TUBA4A/DYNC1I2/MRC2/ATP6V0A2	2.10254607999437
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	13/1174	59/9376	1.75970894811307	PTGER3/AKT3/INSR/ADCY5/ADCY1/IRS2/PRKG1/ADCY6/MGLL/NPPA/PIK3CB/NPY1R/ADCY2	2.2145985129479
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	13/1174	59/9376	1.75970894811307	AKT3/TCF7L2/CDKN1A/EGFR/MYC/TCF7L1/CTNNA1/MAP2K1/MAPK1/PIK3CB/FOXO3/MLH1/ELK1	2.2145985129479
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	24/1174	130/9376	1.47440702398113	CREB5/ACTA2/AKT3/GNAO1/CREB3L2/EGFR/TGFBR1/ADCY5/MAPK10/ADCY1/RXFP1/VEGFA/GNB5/COL4A2/GNG12/ADCY6/COL4A1/MAP2K1/MAPK1/RELA/GNG4/PIK3CB/COL4A6/ADCY2	2.06065670372192
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	19/1174	98/9376	1.54837812467406	AKT3/PLPP1/GSN/SPHK1/ASAP2/PLCG2/PIP5K1A/WASF3/PLA2G4C/AMPH/PIP5K1C/WASF1/ASAP1/MAP2K1/MAPK1/PLA2G6/PIK3CB/PRKCE/ASAP3	2.06455178145053
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	20/1174	106/9376	1.50686252450902	FOXO1/CREB5/AKT3/AR/BCL2/TCF7L2/CREB3L2/CDKN1A/EGFR/PDGFD/PDGFA/TCF7L1/ZEB1/IGF1R/MAP2K1/E2F3/MAPK1/RELA/PIK3CB/PDGFRB	1.9854687322936
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	8/1174	32/9376	1.99659284497445	PFKP/HK1/HK2/UGP2/B4GALT2/PFKM/PGM2/GANC	2.13641758141263
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	13/1174	62/9376	1.67456174094631	TLE2/CTBP2/TLE1/NUMBL/DTX3/SPEN/ADAM17/ITCH/TLE6/NOTCH3/ATXN1/NCOR2/HEYL	2.01608685423349
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	22/1174	120/9376	1.46416808631459	AKT3/NGF/BCL2/MAPKAPK2/MAPK10/MAP3K5/NTRK2/NTRK3/PLCG2/CAMK2D/PTPN11/CAMK2G/ABL1/RAP1B/MAP2K1/MAPK1/NTRK1/RELA/PIK3CB/SH2B1/FOXO3/RPS6KA6	1.93603868819316
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	15/1174	75/9376	1.59727427597956	PFKP/ACO1/ASS1/MAT2A/PRPS2/ENO2/PKM/ALDOA/ALDOB/PFKM/IDH3A/ASL/PSPH/BCAT2/ACO2	1.96471438172207
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	7/1174	27/9376	2.07054072812165	ELOVL5/HACD1/BAAT/ELOVL4/TECR/ELOVL7/ELOVL6	2.10747436581247
Organismal Systems	Endocrine system	hsa04924	Renin secretion	14/1174	69/9376	1.62042317852999	CACNA1C/KCNMA1/PDE1A/EDNRA/ADCY5/REN/ADCY6/ITPR1/PDE1B/NPPA/PPP3CC/AGT/AQP1/PPP3CB	1.95689492498131
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	33/1174	196/9376	1.34464416090116	AKT3/NFATC1/TCF7L2/CDKN1A/MAPKAPK2/MAPK10/VEGFA/MAP1LC3A/PLCG2/MYC/GNB5/TCF7L1/GNG12/STAT3/NFATC4/TRAF3/ANGPT2/ITPR1/MAP2K1/PPP3CC/E2F3/RCAN1/FGF2/MAPK1/BECN1/RELA/GNG4/PIK3CB/HLA-F/JAK1/TICAM1/PPP3CB/ZFP36	1.84474959707556
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	23/1174	128/9376	1.43505110732538	PDE10A/PDE1A/PDE7B/ADCY5/ADCY1/PDE8A/ADA/ADCY6/NME1/ENTPD4/PRPS2/AK4/PDE1B/NT5E/ENTPD1/ENTPD2/PRUNE1/PGM2/PDE7A/AMPD3/GMPS/ADCY2/ATIC	1.87491315768934
Human Diseases	Cancer: specific types	hsa05214	Glioma	15/1174	76/9376	1.57625750919035	AKT3/CDKN1A/EGFR/PDGFA/PLCG2/CAMK2D/IGF1R/CAMK2G/CAMK1/CAMK1D/MAP2K1/E2F3/MAPK1/PIK3CB/PDGFRB	1.90827835277946
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	25/1174	142/9376	1.40605129927778	AKT3/SDC4/BCL2/BMPR1A/MGST1/MAPK10/MAP3K5/ITGB3/CCL2/ITGAV/VEGFA/PDGFA/ACVR1/GPC1/ASS1/PTK2/BMPR1B/GSTM5/GSTM2/RELA/PIK3CB/GSTM4/GSTT2B/IL1R1/PRKAA2	1.84454793436106
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	17/1174	89/9376	1.52548666807036	CACNA1C/PLCL1/GNAO1/ADCY5/ADCY1/GABBR1/GLS/GNB5/GNG12/ADCY6/SLC6A1/GPHN/GABARAPL1/GNG4/SLC38A5/NSF/ADCY2	1.88442469483731
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	28/1174	163/9376	1.37189201617876	CREB5/AKT3/NFATC1/BCL2/HSPG2/CREB3L2/CDKN1A/TGFBR1/MAPK10/MYC/SMAD3/STAT3/NFATC4/EGR3/MAP2K3/TRAF3/STAT5B/MAP2K1/E2F3/MAPK1/RELA/PIK3CB/JAK1/TICAM1/MAVS/STAT5A/TGFB2/ELK1	1.81204895171071
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	29/1174	170/9376	1.36238100010021	AKT3/TXNRD1/TCF7L2/CDKN1A/MGST1/EGFR/TGFBR1/PLCG2/MYC/TCF7L1/SMAD3/SMARCD3/IGF1R/FZD3/WNT5A/MAP2K1/E2F3/GSTM5/WNT5B/MAPK1/CSNK1A1/FZD8/FZD10/GSTM2/PIK3CB/GSTM4/GSTT2B/TGFB2/ELK1	1.80390722837727
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	19/1174	103/9376	1.4732141380394	SERPINE1/AKT3/GNAO1/TGFBR1/MAPK10/ADCY1/CCL2/PPP2R1B/PPP2R2C/MAPK1/PPP2R2D/RELA/PPP2CA/PIK3CB/TICAM1/GNAL/BDKRB2/TGFB2/KNG1	1.82694720803647
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	7/1174	28/9376	1.99659284497445	ELOVL5/HACD1/HADH/ELOVL4/TECR/ELOVL7/ELOVL6	1.99800804610796
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	15/1174	77/9376	1.55578663244762	AKT3/CDKN1A/EGFR/TGFBR1/MAPK10/VEGFA/SMAD3/STAT3/MAP2K1/E2F3/MAPK1/RELA/PIK3CB/JAK1/TGFB2	1.85265750469327
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	24/1174	137/9376	1.39907235852224	AKT3/LMNA/NGF/BCL2/DAB2IP/CAPN2/MAPK10/MAP3K5/ERN1/CTSK/DDIT3/EIF2AK3/PTPN13/TRAF1/MAP3K14/ITPR1/MAP2K1/MCL1/MAPK1/NTRK1/BBC3/RELA/PIK3CB/TUBA4A	1.78016087576218
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	14/1174	71/9376	1.57477745519111	AKT3/ESR1/MAPK10/STAT3/STAT5B/MAP2K1/MAPK1/SOCS5/IRF1/RELA/PIK3CB/LHCGR/FOXO3/STAT5A	1.83920659280958
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	27/1174	158/9376	1.36475966618506	AKT3/CLIP1/INSR/SLC7A5/CAB39L/RNF152/DEPTOR/IGF1R/FZD3/FLCN/RPTOR/WNT5A/MAP2K1/LPIN1/DDIT4/WNT5B/MAPK1/FZD8/ULK1/FZD10/FNIP1/PIK3CB/LPIN3/RPS6KA6/SESN2/PRKAA2/CAB39	1.74935038671652
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	15/1174	78/9376	1.53584064998034	ITGA5/ARHGAP10/VCL/ITGB1/CTTN/SEPTIN1/CLTCL1/WASF1/PTK2/CLTB/CTNNA1/SEPTIN9/PIK3CB/DNM3/CBL	1.79782738569094
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	11/1174	53/9376	1.65754877695992	ATP2B4/ESR1/CLTCL1/ADCY6/SLC8A2/CLTB/ATP1A1/ATP1B2/AP2A1/DNM3/BDKRB2	1.81613392566648
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/1174	47/9376	1.69922795316974	ADH1B/ME3/ACACB/ACYP2/ALDH1B1/PKM/LDHA/ACAT1/ALDH2/ADH5	1.81806735379593
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	29/1174	174/9376	1.33106189664963	BCL2/CAPN2/CRYAB/UBE2G1/DNAJB1/MAPK10/MAP3K5/ERN1/HSPH1/BAG2/UBE2G2/NPLOC4/DDIT3/EIF2AK3/PRKN/SSR3/SEC24D/PPP1R15A/SIL1/HSPA4L/HSPA1B/SEC24A/RNF185/UBQLN1/SEL1L2/SEC23A/SEC61A2/WFS1/UGGT2	1.66764080286348
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	18/1174	99/9376	1.45206752361778	AKT3/ESR1/BCL2/CDKN1A/EGFR/ADCY5/MAPK10/ADCY1/CDKN2C/IGF1R/ADCY6/PTK2/MAP2K1/NOTCH3/E2F3/MAPK1/PIK3CB/ADCY2	1.71071211800794
Organismal Systems	Immune system	hsa04611	Platelet activation	22/1174	126/9376	1.39444579649009	AKT3/MYLK/F2R/STIM1/ADCY5/ITGB3/ADCY1/ITGB1/TLN2/PLCG2/RASGRP2/PTGIR/PLA2G4C/PRKG1/ADCY6/PPP1R12A/RAP1B/ITPR1/MAPK1/PIK3CB/TLN1/ADCY2	1.68640368539767
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	16/1174	86/9376	1.48583653579494	CACNA1C/CREB5/KCNMA1/KCNMB1/CREB3L2/KCNN2/ADCY5/ADCY1/CAMK2D/ADCY6/CAMK2G/ATP1A1/ATP1B2/TRPM4/KCNN3/ADCY2	1.71234529279651
Human Diseases	Cancer: specific types	hsa05218	Melanoma	14/1174	73/9376	1.53163286737766	AKT3/MITF/CDKN1A/EGFR/PDGFD/PDGFA/FGF7/IGF1R/MAP2K1/E2F3/FGF2/MAPK1/PIK3CB/PDGFRB	1.72512888312039
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	14/1174	73/9376	1.53163286737766	AKT3/CDKN1A/EGFR/PLCG2/STAT3/KIF5C/RASSF1/STAT5B/MAP2K1/E2F3/MAPK1/PIK3CB/FOXO3/STAT5A	1.72512888312039
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	35/1174	217/9376	1.28812441611255	CACNA1C/CREB5/AKT3/BCL6/AR/ESR1/PGR/BCL2/CREB3L2/MGST1/EGFR/EPHX1/ADCY5/ADCY1/VEGFA/MYC/STAT3/FGF7/ADCY6/STAT5B/MAP2K1/GSTM5/FGF2/MAPK1/UGT2B7/GSTM2/RELA/KPNA1/PIK3CB/GSTM4/GSTT2B/KPNA6/RPS6KA6/STAT5A/ADCY2	1.62459721435054
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	13/1174	67/9376	1.54959444684584	CACNA1C/ADCY1/CAMK2D/GRIA1/CAMK2G/RAP1B/ITPR1/GRIN2A/MAP2K1/PPP3CC/MAPK1/RPS6KA6/PPP3CB	1.70800062904089
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	16/1174	87/9376	1.46875795492373	AKT3/BCL2/TCF7L2/CDKN1A/EGFR/TGFBR1/MAPK10/MYC/TCF7L1/SMAD3/MAP2K1/MAPK1/BBC3/PIK3CB/MLH1/TGFB2	1.66181854028182
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	8/1174	36/9376	1.77474919553284	GALNT17/GALNT16/GALNT18/GALNT2/GALNT13/GCNT4/B4GALT5/GALNT7	1.76197097669491
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	18/1174	101/9376	1.42331371126891	MITF/GNAO1/TCF7L2/CREB3L2/ADCY5/ADCY1/TCF7L1/CAMK2D/ADCY6/CAMK2G/FZD3/WNT5A/MAP2K1/WNT5B/MAPK1/FZD8/FZD10/ADCY2	1.61817641704835
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	24/1174	142/9376	1.34980924730667	FOSL1/AKT3/MITF/NFATC1/RELB/FOSL2/TGFBR1/MAPK10/ITGB3/PLCG2/CTSK/FHL2/MAP3K14/ITPR1/MAP2K1/PPP3CC/MAPK1/TNFRSF11B/RELA/PIK3CB/JAK1/IL1R1/PPP3CB/TGFB2	1.5890601155262
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	20/1174	115/9376	1.3889341530257	CREB5/AKAP13/BCL2/CREB3L2/CDKN1A/EGFR/STK39/ADCY5/ADCY1/MEF2D/ADCY6/ITPR1/MAP2K1/MAPK1/MMP24/PTHLH/OXSR1/GNA12/MMP17/ADCY2	1.58765400501804
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	21/1174	122/9376	1.37470327031027	CACNA1C/CREB5/AKT3/CREB3L2/SSTR2/ADCY5/MAPK10/ADCY1/PLCG2/STAT3/IRS2/MAP2K3/ADCY6/PTK2/STAT5B/ITPR1/MAP2K1/MAPK1/PIK3CB/STAT5A/ADCY2	1.5760226526788
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	14/1174	75/9376	1.49078932424759	CREB5/ALB/GPX3/CREB3L2/ADCY5/ADCY1/ADCY6/ITPR1/TTF2/ATP1A1/ATP1B2/DUOX1/TTR/ADCY2	1.61443558265331
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	9/1174	43/9376	1.6715661027693	ADH1B/ACSL4/HADH/CPT1C/ALDH1B1/ACAT1/CYP2U1/ALDH2/ADH5	1.66982964175168
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	19/1174	109/9376	1.39211978181705	RORA/NFATC1/IL6R/TGFBR1/MAPK10/SMAD3/IL1RAP/STAT3/STAT5B/HLA-DRB1/IL4R/PPP3CC/MAPK1/RELA/RARA/JAK1/STAT5A/IL1R1/PPP3CB	1.55783775132152
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	8/1174	37/9376	1.72678300105898	CCDC6/TCF7L2/CDKN1A/MYC/TCF7L1/MAP2K1/MAPK1/NTRK1	1.67577319533638
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/1174	31/9376	1.80337418255756	GPI/PFKP/PRPS2/ALDOA/ALDOB/PFKM/PGM2	1.69499674780836
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	13/1174	69/9376	1.50467866577784	CACNA1C/MAOB/CREB5/CREB3L2/ADCY5/CAMK2D/ARC/GRIA1/CAMK2G/GRIN2A/GRIA3/PPP3CC/PPP3CB	1.5918217661484
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	16/1174	89/9376	1.43575215818387	TUBB6/EGFR/ADCY5/TUBB3/PDGFD/ADCY1/PDGFA/PRKG1/ADCY6/HTR2A/ITPR1/MAP2K1/MAPK1/PDGFRB/TUBA4A/ADCY2	1.56263170429357
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	10/1174	50/9376	1.59727427597956	MAOB/CKB/CKMT2/P4HA3/ALDH1B1/P4HA1/ALDH2/L3HYPDH/P4HA2/ODC1	1.6020309840692
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	18/1174	103/9376	1.3956765518268	PPP2R3A/PPP2R1B/SMG6/SMG1/NXT1/ACIN1/PPP2R2C/DDX19A/ETF1/PPP2R2D/PPP2CA/SYMPK/PABPC4/GSPT1/CPSF4/PPP2R5B/CASC3/DDX19B	1.52759631113406
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	18/1174	103/9376	1.3956765518268	LAMA3/ACTN1/VCL/HSPB1/LAMB1/ADCY1/COL4A2/ACTN4/LAMA4/PTK2/COL4A1/RELA/PIK3CB/GNAL/LAMB3/COL4A6/IL1R1/TGFB2	1.52759631113406
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	5/1174	20/9376	1.99659284497445	UAP1/CYB5R3/UGP2/UGDH/GNE	1.68790290361804
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	39/1174	253/9376	1.23110072654551	FOXO1/CD44/ACTN1/ITGA5/AKT3/MYL9/PLCE1/VCL/BCL2/FNBP1/CAPN2/EGFR/MAPK10/ITGB1/TLN2/MAP1LC3A/PLCG2/TRAF5/CTTN/ACTN4/HK1/WASF1/PTK2/HK2/RPTOR/ITPR1/TNIP1/MAPK1/BECN1/SEPTIN9/RELA/PIK3CB/PRKCE/FOXO3/CALCOCO2/DIAPH1/TLN1/IL1R1/CAST	1.40978387285663
Human Diseases	Substance dependence	hsa05032	Morphine addiction	16/1174	91/9376	1.40419716569631	PDE10A/PDE1A/PDE7B/GNAO1/ADCY5/ADCY1/GABBR1/GNB5/GNG12/PDE8A/ADCY6/GRK4/PDE1B/GNG4/PDE7A/ADCY2	1.46582731444617
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	19/1174	112/9376	1.3548308590898	LAMA3/AKT3/BCL2/GNAO1/LAMB1/MAPK10/ITGB1/LDLR/STAT3/LAMA4/MAP2K3/HLA-DRB1/HSPA1B/MAPK1/RELA/JAK1/LAMB3/PPIF/TGFB2	1.42919314685459
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	14/1174	78/9376	1.43345127331499	INPP4B/PLCE1/ITPKC/PLCG2/PIP5K1A/ITPK1/SYNJ2/INPP5B/PIP5K1C/PI4KA/ITPKB/PIK3CB/IPPK/INPP5F	1.45429535731729
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	12/1174	65/9376	1.47440702398113	TRPC4/CACNA1C/AKT3/CACNA1H/KCNN2/GABBR1/ITPR1/MAP2K1/MAPK1/TRPC1/PIK3CB/KCNN3	1.45200940588477
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	5/1174	21/9376	1.90151699521376	DPYD/ALDH1B1/ALDH2/CSAD/BCAT2	1.56466538210457
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	11/1174	59/9376	1.48898449455721	CTPS1/UCK2/DPYD/NME1/ENTPD4/NT5E/ENTPD1/UPP1/CDADC1/CMPK1/NT5C3B	1.42542000747872
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	27/1174	170/9376	1.26842368974847	MYH11/ACTN1/MYL9/MYH9/MAPK10/MAP3K5/ITGB1/PRKAB2/MICALL2/PARD3/TJP2/DLG2/PPP2R1B/CTTN/PRKAG2/HSPA4/ACTN4/ARHGAP17/PPP2R2C/PPP2R2D/PPP2CA/PRKAG1/PRKCE/SYMPK/TUBA4A/PRKAA2/CLDN12	1.33619432053851
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	16/1174	93/9376	1.37399937718672	CACNA1C/EGFR/ADCY5/MAPK10/ADCY1/CAMK2D/PLA2G4C/MAP2K3/ADCY6/CAMK2G/ITPR1/MAP2K1/MAP3K4/MAPK1/ADCY2/ELK1	1.37128581074572
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	24/1174	150/9376	1.27781942078365	AKT3/BCL2/TCF7L2/CDKN1A/EGFR/TGFBR1/MYC/TCF7L1/SMAD3/FGF7/FZD3/WNT5A/CTNNA1/MAP2K1/E2F3/WNT5B/FGF2/MAPK1/CSNK1A1/FZD8/FZD10/PIK3CB/MLH1/TGFB2	1.29766117208424
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	15/1174	87/9376	1.376960582741	CACNB2/TPM1/CACNA1C/TPM2/TPM4/HRC/COX7A1/CASQ2/CACNA2D1/CACNG4/SLC8A2/ASPH/ATP1A1/ATP1B2/SLC9A1	1.33638283633257
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	23/1174	144/9376	1.27560098428923	AKT3/INHBA/BMPR1A/MYC/ID4/ACVR1/SMAD3/STAT3/LIF/IGF1R/FZD3/BMPR1B/WNT5A/MAP2K1/ACVR1B/MEIS1/WNT5B/FGF2/MAPK1/FZD8/FZD10/PIK3CB/JAK1	1.26088046622125
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	15/1174	88/9376	1.36131330339167	SERPINE1/C1S/C1R/F2R/CLU/CFH/SERPING1/MASP1/F10/CFB/PROCR/SERPINF2/C5AR1/BDKRB2/KNG1	1.28832071315397
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	22/1174	138/9376	1.27318964027356	AR/PGR/ADCY5/ADCY1/CPEB2/PPP2R1B/CAMK2D/YWHAG/IGF1R/ADCY6/CAMK2G/ITPR1/MAP2K1/PPP3CC/MAPK1/PPP2CA/ANAPC7/CPEB1/RPS6KA6/PPP3CB/PPP2R5B/ADCY2	1.22313556614824
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/1174	48/9376	1.49744463373083	HADH/OXCT1/AOX1/ALDH1B1/MCCC1/ACAT1/ALDH2/OXCT2/BCAT2	1.30716648527619
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	17/1174	103/9376	1.3181389656142	COL12A1/COL18A1/ACE2/COL7A1/COL8A1/COL4A2/COL6A3/COL6A2/COL4A1/SLC8A2/ATP1A1/COL5A2/ATP1B2/COL5A1/SLC7A8/COL4A6/COL24A1	1.22824541423164
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	15/1174	90/9376	1.33106189664963	AKT3/NFATC1/EGFR/STAT3/BATF3/PTPN11/MAP2K3/MAP2K1/PPP3CC/MAPK1/RELA/PIK3CB/JAK1/TICAM1/PPP3CB	1.19392189871177
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	5/1174	23/9376	1.73616769128213	LARGE1/B3GALNT2/CRPPA/B4GALT2/POMGNT2	1.33728818727844
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	4/1174	17/9376	1.87914620703477	CYP7B1/BAAT/SLC27A5/HSD3B7	1.37255781836955
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	4/1174	17/9376	1.87914620703477	FMO2/GGT5/BAAT/CSAD	1.37255781836955
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	4/1174	17/9376	1.87914620703477	MYH11/PCDH7/MYH9/PCDH9	1.37255781836955
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	11/1174	63/9376	1.39444579649009	TCF7L2/CDKN1A/TCF7L1/FZD3/PTCH2/WNT5A/WNT5B/FZD8/FZD10/GLI2/BMP2	1.18842727270552
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	17/1174	105/9376	1.29303155674536	MITF/RABGEF1/MRAS/MAPK10/MAP1LC3A/RRAS2/SMURF1/EIF2AK3/PRKN/GABARAPL1/BECN1/ULK1/TFE3/RELA/AMBRA1/FOXO3/CALCOCO2	1.14236675407046
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	23/1174	148/9376	1.24112528201114	AKT3/ESR1/PGR/TCF7L2/CDKN1A/EGFR/MYC/TCF7L1/FGF7/IGF1R/FZD3/WNT5A/MAP2K1/NOTCH3/E2F3/WNT5B/FGF2/MAPK1/CSNK1A1/FZD8/FZD10/PIK3CB/HEYL	1.11861236985411
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	12/1174	70/9376	1.36909223655391	AKT3/CDKN1A/VEGFA/PAK3/PTPN11/FLCN/RAP1B/MAP2K1/MAPK1/TFE3/PIK3CB/TGFB2	1.17263326630737
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	16/1174	98/9376	1.30389736814658	INPP4B/PLCE1/ITPKC/DGKI/PLCG2/PIP5K1A/ITPK1/SYNJ2/INPP5B/PIP5K1C/PI4KA/ITPR1/ITPKB/PIK3CB/IPPK/INPP5F	1.14412268570716
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	9/1174	50/9376	1.4375468483816	THBS1/THBS2/THBS3/CSF3/CCL2/COMP/ACKR1/THBS4/TGFB2	1.17360421548298
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	10/1174	57/9376	1.40111778594698	ELOVL5/HACD1/ACSL4/HADH/CPT1C/ELOVL4/TECR/ACAT1/ELOVL7/ELOVL6	1.14917057082883
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	14/1174	85/9376	1.31540234492434	CTPS1/UCK2/ADA/NME1/ENTPD4/AK4/NT5E/ENTPD1/ENTPD2/UPP1/CMPK1/AMPD3/GMPS/NT5C3B	1.10510350121837
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	30/1174	201/9376	1.19199572834295	ZBTB16/FOXO1/PBX1/BCL6/MITF/WT1/CDKN1A/PER2/PDGFA/MYC/MLF1/DDIT3/ETV6/ZEB1/CDKN2C/IGF1R/PTK2/TRAF1/AFF1/GRIA3/MEIS1/DOT1L/NTRK1/TFE3/RELA/RARA/ZBTB17/JMJD1C/SLC45A3/FUT8	1.04098953296107
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	19/1174	122/9376	1.24377914932834	AKT3/NFATC1/MAPK10/PPP2R3A/PPP2R1B/CBLB/PAK3/PTPN11/MAP3K14/MAP2K1/PPP3CC/PPP2R2C/MAPK1/PPP2R2D/RELA/PPP2CA/PIK3CB/PPP3CB/PPP2R5B	1.02534856787905
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	9/1174	52/9376	1.38225658498231	INSR/ADCY5/ADCY1/LDLR/PLA2G4C/IGF1R/ADCY6/LHCGR/ADCY2	1.04571977103383
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	18/1174	116/9376	1.2392645244669	GPI/PFKP/ME3/ACO1/HK1/HK2/PRPS2/ENO2/PKM/ALDOA/AMT/ALDOB/PFKM/IDH3A/ACAT1/ADH5/PSPH/ACO2	0.980983305112271
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	24/1174	160/9376	1.19795570698467	NRXN3/NLGN1/SDC4/NCAM1/NFASC/PTPRS/ITGAV/ITGB1/PVR/ITGA8/NEO1/NEGR1/SLITRK4/NRXN2/CD276/CNTNAP1/HLA-DRB1/ITGB8/NLGN2/ALCAM/SLITRK2/CDH2/HLA-F/CLDN12	0.955468974155486
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	25/1174	168/9376	1.1884481220086	AKT3/IL6R/BCL2/FHL1/IL15/CDKN1A/EGFR/OSMR/CSF3/PDGFA/MYC/STAT3/PIM1/CLCF1/PTPN11/LIF/STAT5B/AOX1/IL4R/MCL1/SOCS5/PIK3CB/JAK1/PDGFRB/STAT5A	0.932445813832623
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	21/1174	139/9376	1.20657409336585	CREB5/AKT3/FKBP5/GREB1/ESR1/PGR/BCL2/GNAO1/CREB3L2/EGFR/ADCY5/ADCY1/GABBR1/ADCY6/HSPA1B/ITPR1/MAP2K1/MAPK1/RARA/PIK3CB/ADCY2	0.928276995332673
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	5/1174	26/9376	1.53584064998034	APOA1/APOB/ABCC1/SLC19A2/BTD	1.03508575005664
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/1174	82/9376	1.26613204803258	MGST1/UCK2/DPYD/NME1/GSTM5/UGT2B7/GSTM2/UPP1/GSTM4/CDADC1/CMPK1/GSTT2B/GMPS	0.915719731820462
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	28/1174	193/9376	1.15864455252403	CCL21/AKT3/CCL14/ADCY5/ADCY1/CCL2/PARD3/PLCG2/RASGRP2/GNB5/GNG12/CXCL12/STAT3/CCL26/CXCL13/ADCY6/GRK4/PTK2/STAT5B/RAP1B/MAP2K1/CCL19/MAPK1/RELA/GNG4/PIK3CB/FOXO3/ADCY2	0.842502756713105
Organismal Systems	Digestive system	hsa04976	Bile secretion	14/1174	90/9376	1.24232443687299	KCNN2/EPHX1/ADCY5/ADCY1/LDLR/ADCY6/BAAT/ATP1A1/ATP1B2/UGT2B7/SLC27A5/AQP1/ADCY2/SLC9A1	0.873904410938142
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	12/1174	76/9376	1.26100600735228	SORBS1/APOA2/APOC3/ACSL4/APOA1/ME3/FABP3/CPT1C/PLIN4/PLIN2/SLC27A5/SLC27A1	0.86432212306535
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	12/1174	76/9376	1.26100600735228	MYLK/SSTR2/ADCY5/ADCY1/CAMK2D/ADCY6/CAMK2G/ITPR1/ATP1A1/ATP1B2/ADCY2/SLC9A1	0.86432212306535
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	5/1174	27/9376	1.47895766294403	HADH/OXCT1/ACAT1/OXCT2/L2HGDH	0.942879584539544
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	65/1174	480/9376	1.08148779102782	CACNA1C/MT-ATP8/GPX3/BCL2/TUBB6/CAPN2/UBE2G1/MAPK10/MAP3K5/KLC1/RYR3/TUBB3/ERN1/MAP1LC3A/UBE2G2/CAMK2D/UCHL1/COX7A1/DNAH7/DDIT3/MCU/GRIA1/EIF2AK3/DKK1/PRKN/KIF5C/MAP2K3/CAMK2G/ATG101/MAP3K10/FZD3/ZFYVE1/IFT57/ITPR1/WNT5A/GRIN2A/DCTN2/MAP2K1/GRIA3/PPP3CC/NDUFA10/WNT5B/MAPK1/BECN1/CSNK1A1/PSMD2/FZD8/ULK1/FZD10/RELA/ATXN1/AMBRA1/DNAL1/PSMD1/SLC25A4/KLC2/WDR41/ATXN2/TUBA4A/DNALI1/NDUFS2/PPIF/LRRK2/PSMD11/PPP3CB	0.693386817743829
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	33/1174	235/9376	1.12149044909203	CNR1/CREB5/MT-ATP8/ZNF516/BMP8A/CREB3L2/ADCY5/MAP3K5/ADCY1/BMP8B/ACSL4/PRKAB2/SMARCD3/COX7A1/PRKAG2/CPT1C/PRKG1/NDUFAF2/MAP2K3/ADCY6/PPARGC1A/MGLL/RPTOR/NPPA/COX20/NDUFA10/PRKAG1/NDUFAF7/RPS6KA6/NDUFS2/PRKAA2/NDUFAF5/ADCY2	0.713574001179394
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	8/1174	49/9376	1.30389736814658	GALNT17/EOGT/GALNT16/GALNT18/GALNT2/GALNT13/B4GALT2/GALNT7	0.806888999686882
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	53/1174	388/9376	1.09092186374892	CACNA1C/AKT3/MT-ATP8/INSR/BACE2/TUBB6/CAPN2/MAPK10/MAP3K5/KLC1/RYR3/TUBB3/SLC39A14/ERN1/COX7A1/DDIT3/MCU/IRS2/SLC39A11/EIF2AK3/DKK1/KIF5C/ATG101/FZD3/ITPR1/WNT5A/GRIN2A/MAP2K1/ADAM17/IDE/PPP3CC/NDUFA10/WNT5B/MAPK1/BECN1/CSNK1A1/PSMD2/FZD8/ULK1/FZD10/RELA/AMBRA1/PIK3CB/SLC39A10/PSMD1/SLC25A4/KLC2/TUBA4A/BACE1/NDUFS2/PPIF/PSMD11/PPP3CB	0.692010150144458
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	7/1174	42/9376	1.33106189664963	MAOB/HADH/KYAT1/AOX1/ALDH1B1/ACAT1/ALDH2	0.813504107129005
NA	NA	hsa04519	Cadherin signaling	55/1174	404/9376	1.08725352944153	DES/CDH13/PCDH7/ACTN1/MYO1D/ENAH/VCL/DAAM1/LHFPL2/MYO1E/CDH6/TCF7L2/LIMA1/EGFR/MRAS/MAPK10/FAT3/DAAM2/YAP1/TCF7L1/RRAS2/PRICKLE2/TEAD4/YWHAG/ACTN4/TEAD3/WASF1/IGF1R/MAP2K3/STK3/TEAD1/PTK2/FZD3/WTIP/LHFPL3/CELSR2/WNT5A/CTNNA1/MAP2K1/WNT5B/MAPK1/CSNK1A1/SCN3B/FZD8/SCN4B/TEAD2/PCDHB4/FZD10/CDH2/RELA/CDH26/PDGFRB/LATS2/PCDH9/NCKAP1	0.67824852451967
Organismal Systems	Digestive system	hsa04970	Salivary secretion	14/1174	93/9376	1.20224945503838	ATP2B4/KCNMA1/ADCY5/RYR3/ADCY1/PRKG1/ADCY6/ITPR1/ATP1A1/ATP1B2/SLC12A2/ADRA1B/ADCY2/SLC9A1	0.741556871060563
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	12/1174	79/9376	1.21311970327561	UNC13B/CLTCL1/CLTB/SLC6A1/STXBP1/SLC6A9/AP2A1/ATP6V0A1/NAPA/DNM3/NSF/ATP6V0A2	0.719656972001122
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	3/1174	15/9376	1.59727427597956	ST6GALNAC6/ST6GALNAC5/ST8SIA1	0.875826580737558
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	4/1174	22/9376	1.45206752361778	MAOB/ALDH1B1/FTCD/ALDH2	0.803111362490913
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	42/1174	308/9376	1.08905064271333	CREB5/MT-ATP8/GPX3/TUBB6/CREB3L2/MAPK10/MAP3K5/KLC1/TUBB3/ERN1/COX7A1/DNAH7/GRIA1/SOD2/CLTCL1/KIF5C/ATG101/TAF4B/MAP3K10/PPARGC1A/TGM2/IFT57/CLTB/ITPR1/DCTN2/GRIA3/NDUFA10/BECN1/PSMD2/ULK1/BBC3/AMBRA1/DNAL1/AP2A1/PSMD1/SLC25A4/KLC2/TUBA4A/DNALI1/NDUFS2/PPIF/PSMD11	0.601196529633879
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	30/1174	216/9376	1.10921824720803	AKT3/NFATC1/BCL2/MAPK10/MAP3K5/CCL2/ERN1/LDLR/APOA1/CAMK2D/APOB/DDIT3/STAT3/HSPA4/SOD2/EIF2AK3/MAP2K3/TRAF3/CAMK2G/PTK2/HSPA1B/RAP1B/ITPR1/HSPD1/PPP3CC/MAPK1/RELA/PIK3CB/TICAM1/PPP3CB	0.61437586324037
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	11/1174	73/9376	1.20342582436816	MAOB/MGST1/ADH1B/FMO2/AOX1/GSTM5/UGT2B7/GSTM2/GSTM4/GSTT2B/ADH5	0.660109234632389
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	6/1174	37/9376	1.29508725079424	MAOB/AOC3/ADH1B/AOX1/ADH5/LRTOMT	0.680394704397268
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	9/1174	59/9376	1.21826004100136	GPX3/MGST1/GCLC/GGT5/GSTM5/GSTM2/GSTM4/GSTT2B/ODC1	0.636241502009546
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	22/1174	157/9376	1.119109365336	AKT3/IL6R/INSR/MAPK10/MAP3K5/ERN1/PRKAB2/COX7A1/DDIT3/PRKAG2/IRS2/EIF2AK3/MLXIP/ITCH/NDUFA10/SREBF1/ADIPOR2/RELA/PRKAG1/PIK3CB/NDUFS2/PRKAA2	0.569394979372535
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	4/1174	23/9376	1.3889341530257	ACE2/REN/ENPEP/AGT	0.706519797907141
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	4/1174	23/9376	1.3889341530257	GLS/ATP1A1/ATP1B2/AQP1	0.706519797907141
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	15/1174	105/9376	1.14091019712825	CCL21/BCL2/RELB/PLCG2/TRAF5/CXCL12/TRAF3/TNFAIP3/TRAF1/MAP3K14/CCL19/RELA/ERC1/TICAM1/IL1R1	0.549330339355626
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	10/1174	68/9376	1.17446637939673	ALDH1A2/ALDH1A3/ADH1B/RDH5/ALDH1A1/AOX1/HSD17B6/UGT2B7/RDH13/ADH5	0.546258014349551
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	5/1174	31/9376	1.28812441611255	AOC3/DPYD/ALDH1B1/ALDH2/CSAD	0.60789848476361
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/1174	31/9376	1.28812441611255	ACO1/AMT/ACAT1/HYI/ACO2	0.60789848476361
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	36/1174	268/9376	1.07279615550866	MAOB/MT-ATP8/TUBB6/UBE2G1/ADCY5/MAPK10/MAP3K5/KLC1/RYR3/TUBB3/SLC39A14/ERN1/UBE2G2/CAMK2D/UCHL1/COX7A1/DDIT3/MCU/SLC39A11/EIF2AK3/PRKN/KIF5C/CAMK2G/ITPR1/NDUFA10/PSMD2/SLC39A10/PSMD1/SLC25A4/KLC2/TUBA4A/GNAL/NDUFS2/PPIF/LRRK2/PSMD11	0.457429463259986
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	4/1174	24/9376	1.33106189664963	XYLT1/EXT1/NDST1/HS6ST3	0.614359212098759
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	43/1174	323/9376	1.06320114345388	TNC/THBS1/TPM1/CD44/TIMP3/ITGA5/SLC7A1/HOXD10/BCL2/HDAC4/CDKN1A/EGFR/ITGB3/VEGFA/GLS/PDGFA/PLCG2/MYC/STAT3/ZEB1/ABCC1/IRS2/PIM1/RASSF1/FOXP1/FZD3/ABL1/RPTOR/MAP2K1/MCL1/NOTCH3/DDIT4/E2F3/SOX4/MAPK1/PIK3CB/PRKCE/EZH2/PDGFRB/SLC45A3/SPRY2/RECK/TGFB2	0.437310334704434
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	3/1174	17/9376	1.40935965527608	TXNRD1/KYAT1/SCLY	0.639108479202055
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	3/1174	17/9376	1.40935965527608	CA12/CA5B/CA13	0.639108479202055
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	19/1174	138/9376	1.09957287114535	ITGA5/AKT3/WIPF3/NFATC1/ARHGEF7/MAPK10/ARHGEF28/CCL2/ITGB1/PIP5K1A/PIP5K1C/MAP2K3/PTK2/MAP2K1/MAPK1/RELA/PIK3CB/TICAM1/RPS6KA6	0.445811634728951
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	16/1174	115/9376	1.11114732242056	CACNA1C/MAOB/GNAO1/KCNN2/KCND2/ADCY5/GNB5/GNG12/CYP4X1/PLA2G4C/HTR2A/ITPR1/MAP2K1/MAPK1/TRPC1/GNG4	0.453710455138082
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	5/1174	32/9376	1.24787052810903	ATG101/RPTOR/GABARAPL1/BECN1/PPP2CA	0.531365398453912
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	21/1174	154/9376	1.08905064271333	MTHFD2/MTHFD1L/CTPS1/GCLC/NME1/MAT2A/ALDH1B1/PMM2/VKORC1/AK4/GPHN/HSD17B6/UGP2/UGDH/UGT2B7/RDH13/FPGS/CMPK1/ALDH2/COQ4/BCAT2	0.42154570031527
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	10/1174	70/9376	1.14091019712825	DMD/SGCD/DTNA/SSPN/ABL2/HLA-DRB1/SNTA1/ABL1/SNTB2/HLA-F	0.447682092306452
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	8/1174	55/9376	1.16165401889422	PLPP1/SGMS2/CERS6/SPHK1/CERS4/UGCG/B4GALT5/CERS5	0.454879537789968
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	13/1174	94/9376	1.10449816956033	FOSL1/MAPK10/CSF3/CCL2/MAPK6/TRAF5/TRAF3/TNFAIP3/TRAF3IP2/IL17D/MAPK1/RELA/IL17RE	0.38522248825884
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	21/1174	156/9376	1.07508845498624	AKT3/CDKN1A/EGFR/MYC/LDLR/PPP2R1B/STAT3/YWHAG/TRAF3/MAP2K1/PPP2R2C/E2F3/MAPK1/PPP2R2D/RELA/PPP2CA/PIK3CB/JAK1/TICAM1/MAVS/CLDN12	0.357791328936351
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	5/1174	33/9376	1.21005626968148	STX18/STX5/STX8/STX16/VTI1A	0.457308473389894
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	14/1174	102/9376	1.09616862077028	ATP2B4/KCNMA1/ADCY5/ADCY1/ADCY6/RAP1B/ITPR1/ATP1A1/ATP1B2/TRPC1/TPCN2/SLC12A2/ADCY2/SLC9A1	0.369453454599382
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	15/1174	110/9376	1.08905064271333	AKT3/PGR/ADCY5/MAPK10/ADCY1/CPEB2/IGF1R/ADCY6/MAP2K1/MAPK1/PIK3CB/ANAPC7/CPEB1/RPS6KA6/ADCY2	0.355424251183044
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	30/1174	227/9376	1.0554675832464	AKT3/MT-ATP8/ABL2/MGST1/EGFR/EPHX1/MAPK10/MAP3K5/VEGFA/PRKD1/COX7A1/PTPN1/PTPN11/SOD2/PTK2/ABL1/MAP3K14/MAP2K1/NDUFA10/GSTM5/MAPK1/GSTM2/RELA/PIK3CB/GSTM4/GSTT2B/SLC25A4/FOXO3/NDUFS2/PPIF	0.320055402780134
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	19/1174	142/9376	1.06859898745111	KLHL13/UBE2E2/UBE2H/UBE2G1/UBR5/UBE2G2/CBLB/UBE2R2/HERC4/SMURF1/PRKN/SAE1/ITCH/MID1/ANAPC7/MGRN1/CBL/UBE2F/UBE2Q2	0.311621021351904
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	26/1174	200/9376	1.03822827938671	MYH11/MYO1D/WIPF3/MYH9/MYO1E/TUBB6/F2R/MAPK10/TUBB3/ITGB1/CTTN/WASF3/PAK3/PTPN11/WASF1/SEC24D/MYO6/ABL1/SEC24A/MAPK1/RELA/GNA12/TUBA4A/IL1R1/CLDN12/NCKAP1	0.206743969689018
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	2/1174	12/9376	1.33106189664963	VKORC1/COQ4	0.434139121880988
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	7/1174	51/9376	1.09616862077028	PLCG2/TJP2/SEC61A2/SLC12A2/ATP6V0A1/KDELR3/ATP6V0A2	0.260527672454897
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	5/1174	36/9376	1.10921824720803	UGP2/UGDH/CRPPA/UGT2B7/SORD	0.248389263022957
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	7/1174	52/9376	1.07508845498624	APOA2/APOC3/OSBPL5/LDLR/APOA1/APOB/SOAT1	0.205415642373117
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	14/1174	108/9376	1.03527036406082	IPO5/NUP98/NUP153/NXT1/NUP188/ACIN1/THOC5/DDX19A/NMD3/KPNA1/KPNA6/IPO7/CASC3/DDX19B	0.139472508440369
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	5/1174	37/9376	1.07923937566186	GFPT2/GLS/ASS1/NIT2/ASL	0.182705458927711
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	6/1174	45/9376	1.0648495173197	ABCC9/ABCC1/ABCA6/ABCD2/ABCB8/ABCA9	0.164971420632978
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	12/1174	93/9376	1.03049953289004	NFATC1/MAPK10/STAT5B/HLA-DRB1/IL4R/PPP3CC/NOTCH3/MAPK1/RELA/JAK1/STAT5A/PPP3CB	0.111827931375404
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	19/1174	149/9376	1.01839635045676	CNR1/CACNA1C/GNAO1/ADCY5/MAPK10/ADCY1/GNB5/GNG12/GRIA1/ADCY6/DAGLB/MGLL/ITPR1/GRIA3/NDUFA10/MAPK1/GNG4/NDUFS2/ADCY2	0.0856356014969926
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	26/1174	205/9376	1.01290563842606	CD44/AKT3/BCL2/RELB/CDKN1A/MAPK10/PLCG2/MYC/TRAF5/STAT3/MAP2K3/TRAF3/HLA-DRB1/TNFAIP3/MAP3K14/E2F3/PSMD2/ENTPD1/RELA/NCOR2/PIK3CB/HLA-F/JAK1/PSMD1/MAVS/PSMD11	0.070681845665484
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	10/1174	78/9376	1.02389376665356	ITGA5/C1S/C1R/MAPK10/ITGB1/SERPING1/MAPK1/IRF1/RELA/TICAM1	0.0801672438226905
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	7/1174	54/9376	1.03527036406082	KYAT1/BHMT2/GCLC/MAT2A/LDHA/AHCY/BCAT2	0.0983358955485253
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	5/1174	38/9376	1.05083833946023	INSR/MAPK1/ATP1A1/ATP1B2/PIK3CB	0.118799886132854
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	4/1174	30/9376	1.0648495173197	ACO1/IDH3A/ACLY/ACO2	0.134590464242146
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	4/1174	30/9376	1.0648495173197	ABCC1/RELA/FPGS/ATIC	0.134590464242146
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	9/1174	71/9376	1.01235693548	EGFR/MAPK10/PLCG2/PTPN11/MAP3K14/ADAM17/RELA/ATP6V0A1/ATP6V0A2	0.039540446474512
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	2/1174	14/9376	1.14091019712825	B4GALT2/FUT8	0.199609830603815
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	13/1174	104/9376	0.998296422487223	PLPP1/SGMS2/DGKI/PLA2G4C/ACHE/GPAT2/GDPD5/LPIN1/PLA2G6/MBOAT7/PCYT1A/LPIN3/CHKA	-0.00660924210772802
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	37/1174	298/9376	0.991596446497376	CCL21/IL1RL1/INHBA/BMP8A/NGF/IL6R/BMPR1A/CCL14/TNFRSF12A/IL15/OSMR/TGFBR1/CSF3/BMP8B/CCL2/ACVR1/CXCL12/IL1RAP/RELL1/CCL26/CXCL13/CLCF1/LIF/IL34/IL4R/BMPR1B/IL17D/ACVR1B/CCL19/IL1RL2/GDF11/TNFRSF11B/TNFRSF8/BMP2/IL17RE/IL1R1/TGFB2	-0.0557745167945239
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	4/1174	31/9376	1.03049953289004	ALDH1B1/UGDH/UGT2B7/ALDH2	0.0643493532412366
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	3/1174	23/9376	1.04170061476928	GLS/ASS1/ASL	0.0757514085358446
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	6/1174	48/9376	0.998296422487223	AKT3/HK1/HK2/ATP1A1/ATP1B2/PIK3CB	-0.00447659755231567
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	8/1174	65/9376	0.98293801598742	PLPP1/DGKI/ALDH1B1/MGLL/GPAT2/LPIN1/LPIN3/ALDH2	-0.0522213205475381
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	4/1174	32/9376	0.998296422487223	BCL2/MAPK10/BECN1/BBC3	-0.00365199586566244
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	6/1174	49/9376	0.977923026109933	MAOB/CREB5/CREB3L2/ADCY5/GRIN2A/RELA	-0.058617379567689
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	25/1174	205/9376	0.973947729255828	ACTN1/CREB5/GSN/HDAC4/CREB3L2/CDKN1A/MAPKAPK2/TRAF5/STAT3/YWHAG/ACTN4/EGR3/TRAF3/STAT5B/TRAF1/PKM/MAPK1/UBR4/RELA/PIK3CB/HLA-F/JAK1/SND1/SRF/STAT5A	-0.142683571256467
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	8/1174	66/9376	0.968045015745186	RORA/NFATC1/SMAD3/STAT3/HLA-DRB1/IL4R/RELA/TGFB2	-0.0985588300112301
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	5/1174	41/9376	0.973947729255828	MAOB/AOC3/DMGDH/AMT/PSPH	-0.0632470325995048
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	11/1174	91/9376	0.965385551416216	AKT3/IFITM1/NFATC1/DAPP1/PLCG2/MAP2K1/PPP3CC/MAPK1/RELA/PIK3CB/PPP3CB	-0.125529836710248
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	14/1174	116/9376	0.963872407918698	ACTN1/MYL9/VCL/ITGB1/PLCG2/CXCL12/ACTN4/PTPN11/PTK2/THY1/RAP1B/CTNNA1/PIK3CB/CLDN12	-0.148122939514865
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	4/1174	33/9376	0.968045015745186	ACO1/IDH3A/BCAT2/ACO2	-0.0695684308253486
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	2/1174	16/9376	0.998296422487223	MAOB/AOC3	-0.00258014295980461
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	2/1174	16/9376	0.998296422487223	A4GALT/ST8SIA1	-0.00258014295980461
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	5/1174	42/9376	0.950758497606879	TF/SLC39A14/ACSL4/MAP1LC3A/GCLC	-0.120999018139501
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	5/1174	43/9376	0.928647834871835	PLPP1/APOA1/APOB/ACAT1/SLC27A1	-0.17741508965812
Human Diseases	Infectious disease: viral	hsa05162	Measles	16/1174	136/9376	0.939573103517386	AKT3/BCL2/MAPK10/RAB9B/CBLB/STAT3/TRAF3/STAT5B/TNFAIP3/HSPA1B/BBC3/RELA/PIK3CB/JAK1/MAVS/STAT5A	-0.268549014063729
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	8/1174	69/9376	0.925956102017135	AKT3/MAPK10/PLCG2/PLA2G4C/MAP2K3/MAP2K1/MAPK1/PIK3CB	-0.233544028016195
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	9/1174	78/9376	0.921504389988206	PFKP/HSPA9/ENO2/HSPD1/PFKM/ZCCHC7/PABPC4/DCP1B/BTG3	-0.263364784550959
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	5/1174	44/9376	0.907542202261112	CPE/PTPRN2/HLA-DRB1/HSPD1/HLA-F	-0.232563910883576
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	9/1174	79/9376	0.90983977745671	MGST1/EPHX1/ADH1B/GSTM5/UGT2B7/GSTM2/GSTM4/GSTT2B/ADH5	-0.304450652629434
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	2/1174	18/9376	0.887374597766421	ACSL4/ACACB	-0.180942627021463
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	21/1174	181/9376	0.926595574463279	AKT3/BCL2/SPHK1/PLA2R1/MAPK10/PLK3/CAMK2D/CAMK2G/EEA1/HLA-DRB1/HSPA9/HSPD1/PPP3CC/MAPK1/RELA/ATP6V0A1/JAK1/PPP3CB/MRC2/TGFB2/ATP6V0A2	-0.377264090294772
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	6/1174	54/9376	0.887374597766421	REV3L/ERCC1/TOP3A/MLH1/ATRIP/POLH	-0.314006392762286
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	7/1174	63/9376	0.887374597766421	PTGIS/PLA2G4C/GGT5/PTGR1/PLA2G6/CYP2U1/LTA4H	-0.339329511950262
NA	NA	hsa04082	Neuroactive ligand signaling	23/1174	199/9376	0.923047948430397	ADRA2C/GNAO1/ADCY5/ADCY1/GABBR1/GNB5/GNG12/GRIA1/ADCY6/HTR2A/GRIK2/ACHE/ADRA2A/SLC6A1/GRIK5/GRIN2A/GRIA3/GNG4/SLC6A9/ADRA1B/ADRA2B/GNAL/ADCY2	-0.415103293638138
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	4/1174	37/9376	0.86339150052949	APOA1/LAMA4/NPPA/KNG1	-0.314983786541847
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	3/1174	28/9376	0.855682647846191	A4GALT/B4GALT2/ST8SIA1	-0.289333033294754
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	32/1174	275/9376	0.929323215115379	CACNA1C/CREB5/MT-ATP8/NCAM1/TUBB6/CREB3L2/MAPK10/KLC1/RYR3/TUBB3/STIP1/COX7A1/DDIT3/MCU/EIF2AK3/KIF5C/HSPA1B/ITPR1/GRIN2A/PPP3CC/NDUFA10/MAPK1/PSMD2/PIK3CB/PSMD1/SLC25A4/KLC2/TUBA4A/NDUFS2/PPIF/PSMD11/PPP3CB	-0.450047526335181
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	43/1174	368/9376	0.933190134064144	MT-ATP8/GPX3/BCL2/TUBB6/MAP3K5/KLC1/TUBB3/ERN1/MAP1LC3A/COX7A1/DNAH7/DDIT3/NUP98/MCU/NUP153/GRIA1/EIF2AK3/PRKN/KIF5C/MAP2K3/ATG101/NXT1/NUP188/GRIN2A/DCTN2/PPP3CC/NDUFA10/BECN1/PSMD2/UBQLN1/ULK1/AMBRA1/DNAL1/ANG/PSMD1/KLC2/WDR41/ATXN2/TUBA4A/DNALI1/NDUFS2/PSMD11/PPP3CB	-0.494663795016457
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	4/1174	38/9376	0.840670671568188	NNMT/AOX1/NT5E/SIRT2	-0.372323452659757
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	2/1174	20/9376	0.798637137989779	SOAT1/LSS	-0.341042945654107
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	21/1174	187/9376	0.896865235175687	BCL2/GBP2/MAPK10/CCL2/MAP1LC3A/TRAF5/PANX1/MCU/TRAF3/TNFAIP3/TP53BP1/ITPR1/GABARAPL1/ANTXR1/MAPK1/RELA/DNM1L/JAK1/TICAM1/MAVS/GBP1	-0.538953832198252
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	24/1174	214/9376	0.895667818306294	AKT3/NFATC1/BCL2/GNAO1/MAPK10/PLCG2/TRAF5/GNB5/GNG12/NFATC4/PAK3/MAP2K3/PTK2/DCAF1/ITPR1/MAP2K1/PPP3CC/MAPK1/RELA/GNG4/PIK3CB/HLA-F/WEE1/PPP3CB	-0.584103537092671
NA	NA	hsa04981	Folate transport and metabolism	3/1174	31/9376	0.772874649667528	BHMT2/ABCC1/FPGS	-0.479199778281137
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	19/1174	173/9376	0.877115931896288	AKT3/DNAJB1/CCL2/NUP98/TRAF3/NXT1/HLA-DRB1/MAP2K1/MAPK1/RELA/KPNA1/PIK3CB/JAK1/SLC25A4/CALCOCO2/TICAM1/MAVS/KPNA6/CPSF4	-0.617182673057996
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	4/1174	41/9376	0.779158183404662	RBBP8/TOP3A/NBN/UIMC1	-0.536137126421641
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	17/1174	158/9376	0.859293123153559	CDKN1A/MYC/PPP2R1B/SMAD3/YWHAG/CDKN2C/CDC14B/ABL1/E2F3/PPP2CA/ZBTB17/CDK7/ANAPC7/WEE1/PPP2R5B/PDS5A/TGFB2	-0.674815919203388
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	7/1174	70/9376	0.798637137989779	MGST1/EPHX1/GSTM5/UGT2B7/GSTM2/GSTM4/GSTT2B	-0.63974466869492
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	18/1174	168/9376	0.855682647846191	BCL2/CAPN2/MAPK10/PYGB/TRAF5/CAMK2D/STAT3/PLA2G4C/PYGM/CAMK2G/STAT5B/TNFAIP3/SPATA2L/DNM1L/JAK1/SLC25A4/TICAM1/STAT5A	-0.714085709344913
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	1/1174	12/9376	0.665530948324815	NCAM1	-0.438607105982679
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	2/1174	23/9376	0.694467076512851	PCYOX1/ACAT1	-0.555016980835451
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	22/1174	205/9376	0.857074001745128	AKT3/MT-ATP8/PLN/INSR/GFPT2/TGFBR1/MAPK10/REN/GYS1/CAMK2D/SMAD3/COX7A1/SLC2A4/CAMK2G/NDUFA10/AGT/RELA/PIK3CB/SLC25A4/NDUFS2/PPIF/TGFB2	-0.78277982202232
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	4/1174	44/9376	0.72603376180889	CHST8/MAN2A1/B4GALT2/FUT8	-0.68912153827981
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	11/1174	109/9376	0.805964084209868	AKT3/MAPK10/CTSK/MAP2K3/TRAF3/MAP2K1/MAPK1/RELA/PIK3CB/JAK1/TICAM1	-0.770877901975236
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	4/1174	46/9376	0.694467076512851	PSME4/PSMD2/PSMD1/PSMD11	-0.785879416041778
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	7/1174	75/9376	0.745394662123793	SERPINE1/THBS1/BCL2/CDKN1A/ZNF385A/BBC3/SESN2	-0.837516010828015
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	6/1174	66/9376	0.72603376180889	CYP7B1/RDH5/HSD17B6/UGT2B7/SULT1E1/LRTOMT	-0.844994686380613
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	2/1174	26/9376	0.614336259992137	PLA2G4C/PLA2G6	-0.744988349820664
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	9/1174	95/9376	0.756603604411369	IL15/CCL2/VEGFA/CTSK/CXCL12/HLA-DRB1/ATP6V0A1/TGFB2/ATP6V0A2	-0.902066101819695
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	1/1174	15/9376	0.532424758659852	AK4	-0.685639481440678
NA	NA	hsa03272	Virion - Hepatitis viruses	4/1174	48/9376	0.665530948324815	HSPG2/EGFR/LDLR/CLDN12	-0.878905319437983
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	26/1174	250/9376	0.83058262350937	MITF/OSBPL5/VPS13A/NCOA7/IDS/OSBPL1A/CTSK/LITAF/DEPTOR/CLTCL1/AP5Z1/ENTPD4/CLTB/RPTOR/TFE3/TPCN2/AP2A1/ATP6V0A1/SLC17A5/LAPTM4B/CLN5/IGF2R/AP3S1/PLEKHM1/OSBP/ATP6V0A2	-1.02718230307066
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	7/1174	78/9376	0.716725636657494	ITGB1/HLA-DRB1/MAPK1/RELA/JAK1/TGFB2/ELK1	-0.950428841298259
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	11/1174	117/9376	0.750855428879279	SMARCD3/CHD3/MORF4L2/GATAD2A/EP400/INO80D/GATAD2B/MBD2/BAZ1B/SMARCA1/CDK2AP2	-1.02594037468554
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	2/1174	28/9376	0.570455098564127	GPHN/FPGS	-0.861168303145432
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	2/1174	28/9376	0.570455098564127	ATP6V0A1/ATP6V0A2	-0.861168303145432
NA	NA	hsa04382	Cornified envelope formation	22/1174	217/9376	0.8096782044136	LAMA3/DST/PPP2R3A/COL7A1/COL4A2/PPP2R1B/UGCG/S100A3/COL4A1/TCHH/KAZN/PPP2R2C/S100A6/ELOVL4/PPP2R2D/PPP2CA/PLEC/LAMB3/COL4A6/PPP2R5B/CLDN12/SLC27A1	-1.07313452678401
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	4/1174	50/9376	0.638909710391823	IL15/CXCL12/HLA-DRB1/MAP3K14	-0.968529627448111
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	9/1174	100/9376	0.718773424190801	CCL21/IL6R/CCL14/CCL2/CXCL12/CCL26/CXCL13/IL34/CCL19	-1.06963546284895
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	9/1174	100/9376	0.718773424190801	CD44/ITGA5/IL6R/ITGB3/CSF3/HLA-DRB1/IL4R/FLT3LG/IL1R1	-1.06963546284895
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	4/1174	51/9376	0.626382069011591	PLPP1/PAFAH1B1/PLA2G4C/PLA2G6	-1.01215769934283
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/1174	41/9376	0.584368637553496	GRIA1/GRIN2A/GRIA3	-1.00902722024378
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/1174	30/9376	0.532424758659852	PGAP1/PIGT	-0.970418461094421
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	2/1174	30/9376	0.532424758659852	PLA2G4C/PLA2G6	-0.970418461094421
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	6/1174	73/9376	0.656414086018996	MAP1B/MAP1A/ELL2/ELL/AFF4/NUP153	-1.11492351284761
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	7/1174	83/9376	0.673549393485355	ACSL4/SOD2/BAAT/CRAT/SLC25A17/HACL1/ABCD2	-1.13015591300326
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	5/1174	63/9376	0.633838998404586	POLE4/CETN2/ERCC1/CDK7/XPC	-1.10320790427815
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	2/1174	31/9376	0.515249766445018	IMMP2L/SEC61A2	-1.02274890980351
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	1/1174	19/9376	0.420335335784094	IDS	-0.956852766659296
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	1/1174	19/9376	0.420335335784094	AMT	-0.956852766659296
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	2/1174	32/9376	0.499148211243612	ACACB/LDHA	-1.07368678450481
Organismal Systems	Sensory system	hsa04742	Taste transduction	7/1174	86/9376	0.650053484410285	CACNA1C/PDE1A/GABBR1/ADCY6/PDE1B/ENTPD2/SCN3A	-1.23339688259574
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	3/1174	44/9376	0.544525321356667	TAF4B/TAF1/CDK7	-1.14567916567604
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/1174	44/9376	0.544525321356667	APTX/POLE4/TDP1	-1.14567916567604
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	4/1174	56/9376	0.570455098564127	HSF1/HSPA1B/HSPD1/RELA	-1.21970394912911
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	2/1174	34/9376	0.469786551758693	POLR1E/CRCP	-1.17173680102948
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	2/1174	36/9376	0.44368729888321	POLE4/PRIM2	-1.265192450649
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	16/1174	180/9376	0.709899678213136	ITGA5/AKT3/BCL2/ITGB3/CCL2/TRAF5/PTPN11/TRAF3/HLA-DRB1/EIF2B3/RELA/PIK3CB/HLA-F/JAK1/TICAM1/MAVS	-1.48677341190027
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/1174	23/9376	0.347233538256425	MLH1	-1.18578537020675
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	5/1174	72/9376	0.554609123604013	MAPK10/TRAF3/ZNFX1/RELA/MAVS	-1.43526640004031
Human Diseases	Immune disease	hsa05330	Allograft rejection	2/1174	39/9376	0.409557506661425	HLA-DRB1/HLA-F	-1.39786758376168
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	7/1174	99/9376	0.564692925851359	C1S/C1R/CFH/MASP1/CFB/HLA-DRB1/C5AR1	-1.64728729204244
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	21/1174	238/9376	0.70467982763804	C1S/C1R/IL6R/EGFR/ACE2/MAPK10/CSF3/CCL2/PLCG2/RPL3/MASP1/STAT3/CFB/TRAF3/ADAM17/MAPK1/RELA/PIK3CB/JAK1/MAVS/C5AR1	-1.74588574523207
Human Diseases	Substance dependence	hsa05034	Alcoholism	16/1174	191/9376	0.669015403551647	MAOB/CREB5/HDAC4/GNAO1/CREB3L2/ADCY5/NTRK2/GNB5/GNG12/GRIN2A/MAP2K1/CAMKK1/MAPK1/GNG4/CAMKK2/CRH	-1.74841567050957
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	3/1174	56/9376	0.427841323923096	MAN2A1/B4GALT2/FUT8	-1.6246594812479
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	2/1174	45/9376	0.354949839106568	HLA-DRB1/HLA-F	-1.64095040056353
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	2/1174	46/9376	0.347233538256425	HEPH/UGT2B7	-1.67901946510938
Human Diseases	Immune disease	hsa05310	Asthma	1/1174	32/9376	0.249574105621806	HLA-DRB1	-1.60870417882438
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	2/1174	54/9376	0.295791532588807	HLA-DRB1/HLA-F	-1.96337554600553
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	1/1174	38/9376	0.210167667892047	ADA	-1.84569346903759
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	4/1174	82/9376	0.389579091702331	HSPA4/HLA-DRB1/HSPA1B/HLA-F	-2.10036511790389
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	8/1174	133/9376	0.480383240896107	NFATC1/PLCG2/PTPN11/MAP2K1/PPP3CC/MAPK1/PIK3CB/PPP3CB	-2.28329643190646
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	29/1174	370/9376	0.625958837883881	PTGER3/CNR1/OXTR/ADRA2C/AVPR1A/EDNRA/F2R/SSTR2/RXFP1/GABBR1/PTGIR/S1PR3/GRP/GRIA1/HTR2A/GRIK2/ADRA2A/GRIK5/GRIN2A/GRIA3/AGT/NPY1R/LHCGR/CRH/ADRA1B/ADRA2B/C5AR1/BDKRB2/KNG1	-2.77724435401298
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	3/1174	83/9376	0.288664025779438	RELA/MAVS/ZDHHC1	-2.46261008971733
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	11/1174	183/9376	0.48005511026708	REXO2/NOP58/NXT1/GNL2/WDR43/MDN1/FCF1/NMD3/GTPBP4/RMRP/UTP14A	-2.68728688799741
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	7/1174	138/9376	0.405105794632496	MT-ATP8/COX7A1/LHPP/NDUFA10/ATP6V0A1/NDUFS2/ATP6V0A2	-2.66348409094819
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	11/1174	195/9376	0.450513257327567	AKT3/HDAC4/ITGB3/PLCG2/MAP2K1/MAPK1/RELA/PIK3CB/SLC25A4/PPIF/C5AR1	-2.9335219012092
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	6/1174	143/9376	0.335092505450257	ACTN1/C1S/C1R/ACTN4/HLA-DRB1/GRIN2A	-3.03122122519164
Genetic Information Processing	Transcription	hsa03040	Spliceosome	8/1174	243/9376	0.262925806745606	RBM25/SNRNP70/HSPA1B/ACIN1/THOC5/PRPF18/SNIP1/CASC3	-4.40420390778433
Genetic Information Processing	Translation	hsa03010	Ribosome	3/1174	222/9376	0.107923937566186	RPL3/MRPL18/DAP3	-5.08900319135973
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	7/1174	449/9376	0.124509130644286	PDE1A/CAMK2D/PRKG1/CAMK2G/SLC8A2/PDE1B/GNAL	-7.19253242459682