ID Description GeneRatio BgRatio RichFactor FoldEnrichment pvalue p.adjust GO:0003712 transcription coregulator activity 166/2813 495/18639 0.335353535353535 2.22205991662088 2.58798432936822e-25 3.23756839603964e-22 GO:0106310 protein serine kinase activity 115/2813 361/18639 0.318559556786704 2.11078264448893 5.05914153312536e-16 3.16449302896991e-13 GO:0004674 protein serine/threonine kinase activity 130/2813 433/18639 0.300230946882217 1.9893368712896 1.19273067149608e-15 4.97368690013864e-13 GO:0141003 histone H2AX kinase activity 108/2813 354/18639 0.305084745762712 2.02149824965204 1.00015207273995e-13 3.1279756074942e-11 GO:0045296 cadherin binding 103/2813 334/18639 0.308383233532934 2.04335410231794 1.76343661841687e-13 3.84565279778028e-11 GO:0140996 histone H3 kinase activity 108/2813 357/18639 0.302521008403361 2.00451086940286 1.84443779270038e-13 3.84565279778028e-11 GO:0035173 histone kinase activity 108/2813 360/18639 0.3 1.98780661215784 3.36448462403334e-13 5.64039610183593e-11 GO:0140297 DNA-binding transcription factor binding 135/2813 488/18639 0.276639344262295 1.83301839235866 3.60696793083033e-13 5.64039610183593e-11 GO:0003725 double-stranded RNA binding 38/2813 75/18639 0.506666666666667 3.35718450053324 5.2073936985491e-13 7.23827724098325e-11 GO:0140857 histone H3T45 kinase activity 81/2813 246/18639 0.329268292682927 2.18173896456348 1.58098544083757e-12 1.40326406815412e-10 GO:0035402 histone H3T11 kinase activity 81/2813 247/18639 0.327935222672065 2.17290601328994 2.00949723508656e-12 1.40326406815412e-10 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity 80/2813 243/18639 0.329218106995885 2.18140643309502 2.18792843642532e-12 1.40326406815412e-10 GO:0004679 AMP-activated protein kinase activity 81/2813 248/18639 0.326612903225806 2.16414429549442 2.54913963050154e-12 1.40326406815412e-10 GO:0031625 ubiquitin protein ligase binding 93/2813 302/18639 0.30794701986755 2.04046374095672 2.88686942385833e-12 1.40326406815412e-10 GO:0004676 3-phosphoinositide-dependent protein kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0004711 ribosomal protein S6 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0035175 histone H3S10 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0035979 histone H2AXS139 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0044022 histone H3S28 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0044023 histone H4S1 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0044024 histone H2AS1 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0044025 histone H2BS14 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0072354 histone H3T3 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0072371 histone H2AS121 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0072518 Rho-dependent protein serine/threonine kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0140823 histone H2BS36 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0140855 histone H3S57 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0140995 histone H2A kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0140997 histone H4 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0140998 histone H2B kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:1990244 histone H2AT120 kinase activity 80/2813 245/18639 0.326530612244898 2.16359903364118 3.52701171657187e-12 1.40326406815412e-10 GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 103/2813 349/18639 0.29512893982808 1.95553086009797 3.589484426933e-12 1.40326406815412e-10 GO:0019787 ubiquitin-like protein transferase activity 130/2813 479/18639 0.271398747390397 1.79829408197995 4.33708053902293e-12 1.64280426082402e-10 GO:0004677 DNA-dependent protein kinase activity 80/2813 246/18639 0.32520325203252 2.15480391561825 4.46485570487742e-12 1.64280426082402e-10 GO:0035403 histone H3T6 kinase activity 80/2813 247/18639 0.323886639676113 2.14608001312587 5.64107533112468e-12 2.01628149692485e-10 GO:0044389 ubiquitin-like protein ligase binding 96/2813 322/18639 0.298136645962733 1.9754599872376 1.02923939002937e-11 3.57660688035207e-10 GO:0016755 aminoacyltransferase activity 132/2813 496/18639 0.266129032258065 1.76337683336582 1.31947250517857e-11 4.46124352426593e-10 GO:0003713 transcription coactivator activity 81/2813 256/18639 0.31640625 2.09651478626022 1.5963260228665e-11 5.25527330159471e-10 GO:0003714 transcription corepressor activity 69/2813 204/18639 0.338235294117647 2.24115451370737 1.76795687597563e-11 5.67106167139876e-10 GO:0004842 ubiquitin-protein transferase activity 120/2813 449/18639 0.267260579064588 1.77087448744574 8.48694270788287e-11 2.65429133189037e-09 GO:0042393 histone binding 76/2813 247/18639 0.307692307692308 2.03877601246958 2.90917918640403e-10 8.87654429802789e-09 GO:0019902 phosphatase binding 62/2813 190/18639 0.326315789473684 2.16217561322432 9.54470120359465e-10 2.84295742992783e-08 GO:0001221 transcription coregulator binding 44/2813 115/18639 0.382608695652174 2.53517365028826 1.02068948213821e-09 2.96949428408118e-08 GO:0019207 kinase regulator activity 82/2813 287/18639 0.285714285714286 1.89314915443604 3.06708593277198e-09 8.72028295885852e-08 GO:0001222 transcription corepressor binding 25/2813 49/18639 0.510204081632653 3.38062349006435 4.10747143079274e-09 1.14187705776038e-07 GO:0032182 ubiquitin-like protein binding 44/2813 120/18639 0.366666666666667 2.42954141485958 4.81211375219391e-09 1.30868571825969e-07 GO:0031490 chromatin DNA binding 44/2813 128/18639 0.34375 2.27769507643086 4.51302116668308e-08 1.2012318041533e-06 GO:0016922 nuclear receptor binding 46/2813 137/18639 0.335766423357664 2.22479572163651 5.09180483139408e-08 1.32705163418208e-06 GO:0004386 helicase activity 50/2813 155/18639 0.32258064516129 2.13742646468585 5.88694596825107e-08 1.50297334822083e-06 GO:0019783 ubiquitin-like protein peptidase activity 43/2813 127/18639 0.338582677165354 2.24345628143798 1.04796458482677e-07 2.62200739123658e-06 GO:0043130 ubiquitin binding 36/2813 100/18639 0.36 2.38536793458941 1.99854727408421e-07 4.9023189017242e-06 GO:0019887 protein kinase regulator activity 70/2813 255/18639 0.274509803921569 1.81890801112482 2.35581645140194e-07 5.66755073212274e-06 GO:0051219 phosphoprotein binding 34/2813 93/18639 0.365591397849462 2.42241665997729 2.8325862335069e-07 6.68597241154177e-06 GO:0061659 ubiquitin-like protein ligase activity 93/2813 372/18639 0.25 1.65650551013153 3.31102571212011e-07 7.67054289974493e-06 GO:0043021 ribonucleoprotein complex binding 53/2813 177/18639 0.299435028248588 1.98406309688071 3.61935226832526e-07 8.23238125031801e-06 GO:0101005 deubiquitinase activity 39/2813 115/18639 0.339130434782609 2.24708573548277 3.84809435114075e-07 8.59636791656621e-06 GO:0035591 signaling adaptor activity 42/2813 129/18639 0.325581395348837 2.15730950156665 4.94942217781115e-07 1.0862679200775e-05 GO:0004843 cysteine-type deubiquitinase activity 37/2813 108/18639 0.342592592592593 2.27002606943951 5.69597949672207e-07 1.22856385351712e-05 GO:0001098 basal transcription machinery binding 25/2813 60/18639 0.416666666666667 2.76084251688589 6.17964286911614e-07 1.27613124958966e-05 GO:0001099 basal RNA polymerase II transcription machinery binding 25/2813 60/18639 0.416666666666667 2.76084251688589 6.17964286911614e-07 1.27613124958966e-05 GO:0043175 RNA polymerase core enzyme binding 20/2813 42/18639 0.476190476190476 3.15524859072673 6.22254246402632e-07 1.27613124958966e-05 GO:0019903 protein phosphatase binding 45/2813 144/18639 0.3125 2.07063188766442 7.2701834752068e-07 1.46693540765866e-05 GO:0000993 RNA polymerase II complex binding 18/2813 36/18639 0.5 3.31301102026306 9.1433227078094e-07 1.8156026519793e-05 GO:0140030 modification-dependent protein binding 51/2813 173/18639 0.294797687861272 1.95333597726493 1.00539838599225e-06 1.96523965761923e-05 GO:0061630 ubiquitin protein ligase activity 87/2813 353/18639 0.246458923512748 1.63304225927981 1.48460671986594e-06 2.85729693315736e-05 GO:0045309 protein phosphorylated amino acid binding 24/2813 59/18639 0.406779661016949 2.69533099953605 1.73590306779683e-06 3.24121602658782e-05 GO:0070063 RNA polymerase binding 24/2813 59/18639 0.406779661016949 2.69533099953605 1.73590306779683e-06 3.24121602658782e-05 GO:0140658 ATP-dependent chromatin remodeler activity 47/2813 158/18639 0.29746835443038 1.97103187281473 1.99025392070366e-06 3.66148184529453e-05 GO:0140597 protein carrier chaperone 53/2813 188/18639 0.281914893617021 1.86797429865896 2.78501196068741e-06 5.04934777220283e-05 GO:0016887 ATP hydrolysis activity 98/2813 417/18639 0.235011990407674 1.55719462822916 3.20947327614686e-06 5.73578724065675e-05 GO:0002039 p53 binding 26/2813 69/18639 0.376811594202899 2.49676192831419 3.61553180896922e-06 6.37046520143731e-05 GO:0140104 molecular carrier activity 65/2813 249/18639 0.261044176706827 1.72968446841044 4.09612518822148e-06 7.11701751453482e-05 GO:0008094 ATP-dependent activity, acting on DNA 57/2813 210/18639 0.271428571428571 1.79849169671423 4.37433703761554e-06 7.49629538911923e-05 GO:0061775 cohesin loader activity 45/2813 153/18639 0.294117647058824 1.94883001191945 4.54281788075357e-06 7.67981779570637e-05 GO:0140713 histone chaperone activity 47/2813 164/18639 0.286585365853659 1.89892095063859 6.14223261573319e-06 0.00010245244003043 GO:0044183 protein folding chaperone 27/2813 75/18639 0.36 2.38536793458941 6.47556137785005e-06 0.000106591148469611 GO:0030695 GTPase regulator activity 110/2813 489/18639 0.224948875255624 1.49051620543533 7.14045477929128e-06 0.000116009206868745 GO:0000510 H3-H4 histone complex chaperone activity 44/2813 151/18639 0.291390728476821 1.93076138929238 7.51784921953284e-06 0.000116109004612785 GO:0140584 chromatin extrusion motor activity 44/2813 151/18639 0.291390728476821 1.93076138929238 7.51784921953284e-06 0.000116109004612785 GO:0140665 ATP-dependent H3-H4 histone complex chaperone activity 44/2813 151/18639 0.291390728476821 1.93076138929238 7.51784921953284e-06 0.000116109004612785 GO:0140849 ATP-dependent H2AZ histone chaperone activity 44/2813 151/18639 0.291390728476821 1.93076138929238 7.51784921953284e-06 0.000116109004612785 GO:0060589 nucleoside-triphosphatase regulator activity 110/2813 490/18639 0.224489795918367 1.48747433562831 7.86554589045557e-06 0.000119997535475121 GO:0140693 molecular condensate scaffold activity 20/2813 48/18639 0.416666666666667 2.76084251688589 8.11662848749118e-06 0.000122336171540379 GO:0015616 DNA translocase activity 44/2813 152/18639 0.289473684210526 1.91805901173125 9.05365013686043e-06 0.000133248427308381 GO:0140674 ATP-dependent histone chaperone activity 44/2813 152/18639 0.289473684210526 1.91805901173125 9.05365013686043e-06 0.000133248427308381 GO:1990841 promoter-specific chromatin binding 25/2813 68/18639 0.367647058823529 2.43603751489931 9.20504829864169e-06 0.000133901342111637 GO:0001727 lipid kinase activity 18/2813 41/18639 0.439024390243902 2.90898528608464 9.53376675915414e-06 0.000137088990985078 GO:0003724 RNA helicase activity 27/2813 77/18639 0.350649350649351 2.32341032589877 1.13683861074413e-05 0.00016161194341374 GO:0008234 cysteine-type peptidase activity 51/2813 187/18639 0.272727272727273 1.80709692014349 1.18005446682612e-05 0.000164558384820091 GO:0051082 unfolded protein binding 37/2813 121/18639 0.305785123966942 2.02613897106997 1.18387327208699e-05 0.000164558384820091 GO:0019208 phosphatase regulator activity 36/2813 117/18639 0.307692307692308 2.03877601246958 1.32546313983155e-05 0.000182214767904315 GO:0031491 nucleosome binding 26/2813 74/18639 0.351351351351351 2.32806179802269 1.57660488664205e-05 0.000212631926004148 GO:0042826 histone deacetylase binding 38/2813 127/18639 0.299212598425197 1.98258927196845 1.58071695590614e-05 0.000212631926004148 GO:0008186 ATP-dependent activity, acting on RNA 27/2813 79/18639 0.341772151898734 2.26458981131906 1.94191016450181e-05 0.000258439320828911 GO:0051059 NF-kappaB binding 15/2813 32/18639 0.46875 3.10594783149662 2.02085096528917e-05 0.000266114163955448 GO:0001784 phosphotyrosine residue binding 19/2813 47/18639 0.404255319148936 2.67860465468077 2.28341285915169e-05 0.000294489637814306 GO:0140938 histone H3 methyltransferase activity 19/2813 47/18639 0.404255319148936 2.67860465468077 2.28341285915169e-05 0.000294489637814306 GO:0019209 kinase activator activity 42/2813 148/18639 0.283783783783784 1.88035760609525 2.42228384803895e-05 0.000309211948356809 GO:0030295 protein kinase activator activity 40/2813 139/18639 0.287769784172662 1.9067689325255 2.63258286677935e-05 0.000332662744074845 GO:0019888 protein phosphatase regulator activity 33/2813 107/18639 0.308411214953271 2.04353950782582 2.82957669922973e-05 0.000353980045073639 GO:0031072 heat shock protein binding 38/2813 131/18639 0.290076335877863 1.92205219496178 3.40963262549008e-05 0.000422321823216643 GO:0003689 DNA clamp loader activity 44/2813 160/18639 0.275 1.82215606114469 3.65585827909337e-05 0.000448380265406452 GO:0023023 MHC protein complex binding 16/2813 37/18639 0.432432432432432 2.86530682833562 3.73976375862003e-05 0.000454217908935307 GO:0005085 guanyl-nucleotide exchange factor activity 58/2813 230/18639 0.252173913043478 1.67090990587181 3.91508560631666e-05 0.000470939624375206 GO:0032452 histone demethylase activity 14/2813 30/18639 0.466666666666667 3.09214361891219 4.0673587730689e-05 0.000484596745248494 GO:0061650 ubiquitin-like protein conjugating enzyme activity 17/2813 41/18639 0.414634146341463 2.74737499241327 4.14951477292449e-05 0.000489721035936655 GO:0001217 DNA-binding transcription repressor activity 67/2813 278/18639 0.241007194244604 1.59691898099011 4.82930250579974e-05 0.000564622190164063 GO:0015631 tubulin binding 87/2813 385/18639 0.225974025974026 1.49730887669032 5.24987064778997e-05 0.000608110016702338 GO:0140033 acetylation-dependent protein binding 12/2813 24/18639 0.5 3.31301102026306 6.22377048928886e-05 0.00071430613597251 GO:0140457 protein demethylase activity 14/2813 31/18639 0.451612903225806 2.99239705056019 6.38973020284893e-05 0.000726686589433092 GO:0061631 ubiquitin conjugating enzyme activity 15/2813 35/18639 0.428571428571429 2.83972373165405 7.40344601034873e-05 0.000832025066640868 GO:0035259 nuclear glucocorticoid receptor binding 8/2813 12/18639 0.666666666666667 4.41734802701742 7.44898540877515e-05 0.000832025066640868 GO:0003727 single-stranded RNA binding 28/2813 89/18639 0.314606741573034 2.08459120376103 7.52389450360847e-05 0.000832955046372938 GO:0046966 nuclear thyroid hormone receptor binding 13/2813 28/18639 0.464285714285714 3.07636737595856 8.19852553327348e-05 0.000884168572596994 GO:0051019 mitogen-activated protein kinase binding 13/2813 28/18639 0.464285714285714 3.07636737595856 8.19852553327348e-05 0.000884168572596994 GO:0141052 histone H3 demethylase activity 13/2813 28/18639 0.464285714285714 3.07636737595856 8.19852553327348e-05 0.000884168572596994 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 64/2813 268/18639 0.238805970149254 1.58233362161818 9.38484438383762e-05 0.00100345643796418 GO:0008139 nuclear localization sequence binding 12/2813 25/18639 0.48 3.18049057945254 0.000103278417782701 0.00108572521551394 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding 12/2813 25/18639 0.48 3.18049057945254 0.000103278417782701 0.00108572521551394 GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity 36/2813 128/18639 0.28125 1.86356869889797 0.000109214946845141 0.00113856582086059 GO:0043539 protein serine/threonine kinase activator activity 24/2813 73/18639 0.328767123287671 2.17841820510448 0.000111325928990046 0.00115098129889709 GO:0140662 ATP-dependent protein folding chaperone 16/2813 40/18639 0.4 2.65040881621045 0.000116365554310507 0.00119322383969216 GO:0051087 protein-folding chaperone binding 37/2813 134/18639 0.276119402985075 1.82957324999602 0.000133938713799533 0.00136225472327818 GO:0099122 RNA polymerase II C-terminal domain binding 7/2813 10/18639 0.7 4.63821542836829 0.000139322835214083 0.00140558763590982 GO:0000287 magnesium ion binding 56/2813 230/18639 0.243478260869565 1.61329232291071 0.000145327065917123 0.00144327418824452 GO:0140311 protein sequestering activity 14/2813 33/18639 0.424242424242424 2.81103965355654 0.000146498320615189 0.00144327418824452 GO:0140097 catalytic activity, acting on DNA 76/2813 336/18639 0.226190476190476 1.4987430805952 0.000146519441972065 0.00144327418824452 GO:1990380 K48-linked deubiquitinase activity 10/2813 19/18639 0.526315789473684 3.48738002132954 0.000149803871323892 0.0014640987736421 GO:0004713 protein tyrosine kinase activity 38/2813 140/18639 0.271428571428571 1.79849169671423 0.000161636480988636 0.00156749796679677 GO:0004715 non-membrane spanning protein tyrosine kinase activity 17/2813 45/18639 0.377777777777778 2.50316388197654 0.000165392267315662 0.00157943302604499 GO:0042605 peptide antigen binding 17/2813 45/18639 0.377777777777778 2.50316388197654 0.000165392267315662 0.00157943302604499 GO:0046975 histone H3K36 methyltransferase activity 8/2813 13/18639 0.615384615384615 4.07755202493916 0.000167957564101409 0.00159177964159744 GO:0051721 protein phosphatase 2A binding 13/2813 30/18639 0.433333333333333 2.87127621756132 0.000195020051790606 0.00183243704302675 GO:0061980 regulatory RNA binding 20/2813 58/18639 0.344827586206897 2.28483518638832 0.000196280226831003 0.00183243704302675 GO:0140463 chromatin-protein adaptor activity 19/2813 54/18639 0.351851851851852 2.3313781253703 0.000208478869426006 0.00193099746969332 GO:0070577 lysine-acetylated histone binding 11/2813 23/18639 0.478260869565217 3.16896706286032 0.000209924585034606 0.00193099746969332 GO:0035198 miRNA binding 16/2813 42/18639 0.380952380952381 2.52419887258138 0.000228480245791399 0.00208634151448935 GO:0051020 GTPase binding 71/2813 315/18639 0.225396825396825 1.49348433294398 0.000265160789618467 0.00240374020154132 GO:0140313 molecular sequestering activity 19/2813 55/18639 0.345454545454545 2.28898943218175 0.00027389126808435 0.00246502141275915 GO:0140098 catalytic activity, acting on RNA 84/2813 387/18639 0.217054263565891 1.43820633437776 0.00028997795315801 0.00259116013857621 GO:0032183 SUMO binding 9/2813 17/18639 0.529411764705882 3.50789402145501 0.000306997476111773 0.00272378611784276 GO:0097718 disordered domain specific binding 12/2813 28/18639 0.428571428571429 2.83972373165405 0.000388633730309224 0.00342380842687915 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 17/2813 48/18639 0.354166666666667 2.346716139353 0.00040571146320012 0.00354884829446921 GO:0004197 cysteine-type endopeptidase activity 26/2813 88/18639 0.295454545454545 1.95768833015545 0.00040850052310437 0.00354884829446921 GO:0001046 core promoter sequence-specific DNA binding 16/2813 44/18639 0.363636363636364 2.40946256019132 0.000424021631746278 0.00365828318147995 GO:0032451 demethylase activity 15/2813 40/18639 0.375 2.4847582651973 0.0004348821386147 0.00372628462607527 GO:0140296 general transcription initiation factor binding 18/2813 53/18639 0.339622641509434 2.25034710810321 0.000498446532888215 0.00424188171866093 GO:0042974 nuclear retinoic acid receptor binding 11/2813 25/18639 0.44 2.9154496978315 0.000516871255122491 0.00436895905512322 GO:0071889 14-3-3 protein binding 13/2813 33/18639 0.393939393939394 2.61025110687393 0.000599393693924445 0.00503249336308376 GO:0042054 histone methyltransferase activity 21/2813 67/18639 0.313432835820896 2.07681287837386 0.000604316872738359 0.00504000271863791 GO:0061578 K63-linked deubiquitinase activity 8/2813 15/18639 0.533333333333333 3.53387842161393 0.000632192095623788 0.00523756497765138 GO:0140035 ubiquitin-like protein reader activity 10/2813 22/18639 0.454545454545455 3.01182820023915 0.000679029559020559 0.00550245404920801 GO:0005095 GTPase inhibitor activity 7/2813 12/18639 0.583333333333333 3.86517952364024 0.000694954228437142 0.00550245404920801 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity 7/2813 12/18639 0.583333333333333 3.86517952364024 0.000694954228437142 0.00550245404920801 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity 7/2813 12/18639 0.583333333333333 3.86517952364024 0.000694954228437142 0.00550245404920801 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity 7/2813 12/18639 0.583333333333333 3.86517952364024 0.000694954228437142 0.00550245404920801 GO:0140844 NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity 7/2813 12/18639 0.583333333333333 3.86517952364024 0.000694954228437142 0.00550245404920801 GO:0140867 NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity 7/2813 12/18639 0.583333333333333 3.86517952364024 0.000694954228437142 0.00550245404920801 GO:0035401 histone H3Y41 kinase activity 31/2813 115/18639 0.269565217391304 1.786145071794 0.000704382753580266 0.0055073926545557 GO:0140801 histone H2AXY142 kinase activity 31/2813 115/18639 0.269565217391304 1.786145071794 0.000704382753580266 0.0055073926545557 GO:0030291 protein serine/threonine kinase inhibitor activity 16/2813 46/18639 0.347826086956522 2.30470331844387 0.000748555137388469 0.00581641289983214 GO:0052742 phosphatidylinositol kinase activity 11/2813 26/18639 0.423076923076923 2.80331701714567 0.000774516143859228 0.00598098577757959 GO:0004402 histone acetyltransferase activity 15/2813 42/18639 0.357142857142857 2.36643644304505 0.000792395583599256 0.00608151457105932 GO:0016779 nucleotidyltransferase activity 35/2813 136/18639 0.257352941176471 1.70522626042952 0.000835980367032969 0.00637689901925758 GO:0140036 ubiquitin-modified protein reader activity 9/2813 19/18639 0.473684210526316 3.13864201919659 0.000875851572725083 0.00664054737866108 GO:0003743 translation initiation factor activity 17/2813 51/18639 0.333333333333333 2.20867401350871 0.0009011681384561 0.00679133338077459 GO:0008135 translation factor activity, RNA binding 24/2813 83/18639 0.289156626506024 1.9159581803931 0.000940035897457562 0.00704182579472701 GO:0061733 protein-lysine-acetyltransferase activity 16/2813 47/18639 0.340425531914894 2.25566707762592 0.000977793164168292 0.00728106695461032 GO:0004712 protein serine/threonine/tyrosine kinase activity 15/2813 43/18639 0.348837209302326 2.31140303739284 0.00104904119527702 0.00776538778279023 GO:0046332 SMAD binding 23/2813 79/18639 0.291139240506329 1.92909502445697 0.00107331460337476 0.00789833275777546 GO:0023026 MHC class II protein complex binding 11/2813 27/18639 0.407407407407407 2.69949046095509 0.00113016208598042 0.00822385021757123 GO:0180051 translation factor activity 24/2813 84/18639 0.285714285714286 1.89314915443604 0.00113069723215208 0.00822385021757123 GO:0010485 histone H4 acetyltransferase activity 13/2813 35/18639 0.371428571428571 2.46109390076685 0.00115025434302435 0.00826993208691648 GO:0140566 histone reader activity 13/2813 35/18639 0.371428571428571 2.46109390076685 0.00115025434302435 0.00826993208691648 GO:0140767 enzyme-substrate adaptor activity 35/2813 139/18639 0.251798561151079 1.66842281595982 0.00126751184894596 0.00906089898875083 GO:0031267 small GTPase binding 62/2813 283/18639 0.219081272084806 1.45163733750042 0.00132928304411238 0.00944848345559427 GO:0043024 ribosomal small subunit binding 9/2813 20/18639 0.45 2.98170991823676 0.00138043381082805 0.00975662540873387 GO:0019210 kinase inhibitor activity 25/2813 90/18639 0.277777777777778 1.84056167792392 0.00140189066297807 0.00985261359205376 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity 6/2813 10/18639 0.6 3.97561322431568 0.00142479578628714 0.00990233071469562 GO:0051864 histone H3K36 demethylase activity 6/2813 10/18639 0.6 3.97561322431568 0.00142479578628714 0.00990233071469562 GO:0008276 protein methyltransferase activity 26/2813 95/18639 0.273684210526316 1.81343761109136 0.00143972675689875 0.00995081863469802 GO:0036408 histone H3K14 acetyltransferase activity 11/2813 28/18639 0.392857142857143 2.60308008734955 0.00160997455141473 0.0110663635374716 GO:1990226 histone methyltransferase binding 8/2813 17/18639 0.470588235294118 3.11812801907112 0.00180032097918131 0.0123071122675182 GO:0017069 snRNA binding 17/2813 54/18639 0.314814814814815 2.08596990164711 0.00183839918072576 0.0124991161689561 GO:0008017 microtubule binding 60/2813 276/18639 0.217391304347826 1.44043957402742 0.00190542696869714 0.0128848061504871 GO:1990782 protein tyrosine kinase binding 30/2813 117/18639 0.256410256410256 1.69898001039131 0.00201062419413868 0.0135230691767069 GO:0031593 polyubiquitin modification-dependent protein binding 18/2813 59/18639 0.305084745762712 2.02149824965204 0.00203286123717504 0.0135271777005637 GO:0036002 pre-mRNA binding 18/2813 59/18639 0.305084745762712 2.02149824965204 0.00203286123717504 0.0135271777005637 GO:0035613 RNA stem-loop binding 9/2813 21/18639 0.428571428571429 2.83972373165405 0.00209475503248322 0.013792308134929 GO:0051010 microtubule plus-end binding 9/2813 21/18639 0.428571428571429 2.83972373165405 0.00209475503248322 0.013792308134929 GO:0010484 histone H3 acetyltransferase activity 11/2813 29/18639 0.379310344827586 2.51331870502715 0.00224397817964363 0.014697469647823 GO:0044548 S100 protein binding 7/2813 14/18639 0.5 3.31301102026306 0.00227959409633424 0.0148529802839278 GO:0016279 protein-lysine N-methyltransferase activity 20/2813 69/18639 0.289855072463768 1.92058609870323 0.00234003369943792 0.0151677832020561 GO:0016706 2-oxoglutarate-dependent dioxygenase activity 18/2813 60/18639 0.3 1.98780661215784 0.00250116880145998 0.0161286709826105 GO:0004860 protein kinase inhibitor activity 23/2813 84/18639 0.273809523809524 1.81426793966787 0.00261434018787615 0.0167719978206824 GO:0070990 snRNP binding 6/2813 11/18639 0.545454545454545 3.61419384028698 0.0027349307177517 0.0174561139178948 GO:0016278 lysine N-methyltransferase activity 20/2813 70/18639 0.285714285714286 1.89314915443604 0.00281954052353093 0.0178143696714 GO:0097110 scaffold protein binding 20/2813 70/18639 0.285714285714286 1.89314915443604 0.00281954052353093 0.0178143696714 GO:1990518 single-stranded 3'-5' DNA helicase activity 15/2813 47/18639 0.319148936170213 2.1146878852743 0.0028784620320025 0.0180952562916338 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 39/2813 167/18639 0.233532934131737 1.54739436874562 0.00306215000158455 0.018764222963974 GO:0043995 histone H4K5 acetyltransferase activity 11/2813 30/18639 0.366666666666667 2.42954141485958 0.00306596848280897 0.018764222963974 GO:0043996 histone H4K8 acetyltransferase activity 11/2813 30/18639 0.366666666666667 2.42954141485958 0.00306596848280897 0.018764222963974 GO:0043997 histone H4K12 acetyltransferase activity 11/2813 30/18639 0.366666666666667 2.42954141485958 0.00306596848280897 0.018764222963974 GO:0050321 tau-protein kinase activity 9/2813 22/18639 0.409090909090909 2.71064538021523 0.00307487266795737 0.018764222963974 GO:0070034 telomerase RNA binding 9/2813 22/18639 0.409090909090909 2.71064538021523 0.00307487266795737 0.018764222963974 GO:0050681 nuclear androgen receptor binding 10/2813 26/18639 0.384615384615385 2.54847001558697 0.00313614223044569 0.0190452132538231 GO:0048156 tau protein binding 14/2813 43/18639 0.325581395348837 2.15730950156665 0.00319688903565431 0.0193203293893891 GO:0005096 GTPase activator activity 58/2813 271/18639 0.214022140221402 1.41811541826758 0.00323142341571188 0.0194351475627671 GO:0140789 histone phosphatase activity 33/2813 136/18639 0.242647058823529 1.60778475983355 0.0032551895891516 0.019484412325496 GO:0036121 double-stranded DNA helicase activity 15/2813 48/18639 0.3125 2.07063188766442 0.00361238385807076 0.0213344869301208 GO:0043138 3'-5' DNA helicase activity 15/2813 48/18639 0.3125 2.07063188766442 0.00361238385807076 0.0213344869301208 GO:0003779 actin binding 88/2813 443/18639 0.198645598194131 1.31623011188781 0.00361543663404126 0.0213344869301208 GO:0042809 nuclear vitamin D receptor binding 7/2813 15/18639 0.466666666666667 3.09214361891219 0.00372107084695589 0.0218547400447973 GO:1990756 ubiquitin-like ligase-substrate adaptor activity 30/2813 122/18639 0.245901639344262 1.62934968209659 0.00395271223543199 0.0230533403012501 GO:0034212 protein N-acetyltransferase activity 16/2813 53/18639 0.30188679245283 2.00030854053619 0.00396200492787272 0.0230533403012501 GO:0043022 ribosome binding 28/2813 112/18639 0.25 1.65650551013153 0.00409981759664968 0.0237447769139294 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 22/2813 82/18639 0.268292682926829 1.77771323038506 0.00419307585736617 0.0241365439302761 GO:0005520 insulin-like growth factor binding 8/2813 19/18639 0.421052631578947 2.78990401706363 0.00422534222280613 0.0241365439302761 GO:0042800 histone H3K4 methyltransferase activity 8/2813 19/18639 0.421052631578947 2.78990401706363 0.00422534222280613 0.0241365439302761 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity 9/2813 23/18639 0.391304347826087 2.59279123324935 0.00438308253656656 0.0248110237703383 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity 9/2813 23/18639 0.391304347826087 2.59279123324935 0.00438308253656656 0.0248110237703383 GO:0005078 MAP-kinase scaffold activity 6/2813 12/18639 0.5 3.31301102026306 0.00477490720706628 0.0269072473695492 GO:0008170 N-methyltransferase activity 25/2813 98/18639 0.255102040816327 1.69031174503218 0.00488342932019287 0.0273953815226963 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 22/2813 83/18639 0.265060240963855 1.75629499869367 0.00490896712450397 0.0274157047890824 GO:0032813 tumor necrosis factor receptor superfamily binding 15/2813 50/18639 0.3 1.98780661215784 0.00553935948999288 0.0307988387643604 GO:0003678 DNA helicase activity 20/2813 74/18639 0.27027027027027 1.79081676770976 0.0056356588476025 0.0310581903892102 GO:0003684 damaged DNA binding 20/2813 74/18639 0.27027027027027 1.79081676770976 0.0056356588476025 0.0310581903892102 GO:0016410 N-acyltransferase activity 24/2813 94/18639 0.25531914893617 1.69175030821944 0.00567746932679242 0.0311513777535847 GO:0042287 MHC protein binding 13/2813 41/18639 0.317073170731707 2.1009338177278 0.0057045727463659 0.0311634083218504 GO:0004708 MAP kinase kinase activity 7/2813 16/18639 0.4375 2.89888464273018 0.00576156333347269 0.0313378944790188 GO:0017124 SH3 domain binding 28/2813 115/18639 0.243478260869565 1.61329232291071 0.00605655015552197 0.0327997586344501 GO:0042288 MHC class I protein binding 8/2813 20/18639 0.4 2.65040881621045 0.00612194783079153 0.0330110204151733 GO:0120013 lipid transfer activity 18/2813 65/18639 0.276923076923077 1.83489841122262 0.00639599917770768 0.0343407509498382 GO:0005516 calmodulin binding 45/2813 207/18639 0.217391304347826 1.44043957402742 0.00650380666031781 0.034770350991699 GO:0003924 GTPase activity 67/2813 331/18639 0.202416918429003 1.34121896288595 0.00657342431335832 0.03499299496175 GO:0005048 signal sequence binding 15/2813 51/18639 0.294117647058824 1.94883001191945 0.00677439913601674 0.0359100564371057 GO:0140416 transcription regulator inhibitor activity 11/2813 33/18639 0.333333333333333 2.20867401350871 0.00704909199347652 0.037208498244047 GO:0033192 calmodulin-dependent protein phosphatase activity 21/2813 81/18639 0.259259259259259 1.71785756606233 0.00773268575717059 0.0384903113953856 GO:0140791 histone H2AXS140 phosphatase activity 21/2813 81/18639 0.259259259259259 1.71785756606233 0.00773268575717059 0.0384903113953856 GO:0180004 RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity 21/2813 81/18639 0.259259259259259 1.71785756606233 0.00773268575717059 0.0384903113953856 GO:0180005 RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity 21/2813 81/18639 0.259259259259259 1.71785756606233 0.00773268575717059 0.0384903113953856 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity 21/2813 81/18639 0.259259259259259 1.71785756606233 0.00773268575717059 0.0384903113953856 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity 21/2813 81/18639 0.259259259259259 1.71785756606233 0.00773268575717059 0.0384903113953856 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity 21/2813 81/18639 0.259259259259259 1.71785756606233 0.00773268575717059 0.0384903113953856 GO:1990439 MAP kinase serine/threonine phosphatase activity 21/2813 81/18639 0.259259259259259 1.71785756606233 0.00773268575717059 0.0384903113953856 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 6/2813 13/18639 0.461538461538462 3.05816401870437 0.00774501309584125 0.0384903113953856 GO:0031994 insulin-like growth factor I binding 6/2813 13/18639 0.461538461538462 3.05816401870437 0.00774501309584125 0.0384903113953856 GO:0140666 annealing activity 6/2813 13/18639 0.461538461538462 3.05816401870437 0.00774501309584125 0.0384903113953856 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity 6/2813 13/18639 0.461538461538462 3.05816401870437 0.00774501309584125 0.0384903113953856 GO:0140852 histone ubiquitin ligase activity 6/2813 13/18639 0.461538461538462 3.05816401870437 0.00774501309584125 0.0384903113953856 GO:0043495 protein-membrane adaptor activity 14/2813 47/18639 0.297872340425532 1.97370869292268 0.00775344402209206 0.0384903113953856 GO:0061749 forked DNA-dependent helicase activity 14/2813 47/18639 0.297872340425532 1.97370869292268 0.00775344402209206 0.0384903113953856 GO:0030159 signaling receptor complex adaptor activity 15/2813 52/18639 0.288461538461538 1.91135251169023 0.00822050077169357 0.0406476144877022 GO:0019211 phosphatase activator activity 9/2813 25/18639 0.36 2.38536793458941 0.0082575770528055 0.040670192492361 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 8/2813 21/18639 0.380952380952381 2.52419887258138 0.00860022032205818 0.0418633292719641 GO:0009931 calcium-dependent protein serine/threonine kinase activity 8/2813 21/18639 0.380952380952381 2.52419887258138 0.00860022032205818 0.0418633292719641 GO:0072542 protein phosphatase activator activity 8/2813 21/18639 0.380952380952381 2.52419887258138 0.00860022032205818 0.0418633292719641 GO:0033549 MAP kinase phosphatase activity 21/2813 82/18639 0.25609756097561 1.69690808354937 0.00895123998497208 0.0432355259505794 GO:0140272 exogenous protein binding 21/2813 82/18639 0.25609756097561 1.69690808354937 0.00895123998497208 0.0432355259505794 GO:0030332 cyclin binding 11/2813 34/18639 0.323529411764706 2.14371301311139 0.00902649230559699 0.0434313149011609 GO:0009378 four-way junction helicase activity 14/2813 48/18639 0.291666666666667 1.93258976182012 0.00945858644257145 0.0453359832937045 GO:0004722 protein serine/threonine phosphatase activity 25/2813 103/18639 0.242718446601942 1.60825777682673 0.00952396641522894 0.0454751220818756 GO:0030957 Tat protein binding 5/2813 10/18639 0.5 3.31301102026306 0.010116570586235 0.0477578483146413 GO:0045322 unmethylated CpG binding 5/2813 10/18639 0.5 3.31301102026306 0.010116570586235 0.0477578483146413 GO:0140999 histone H3K4 trimethyltransferase activity 5/2813 10/18639 0.5 3.31301102026306 0.010116570586235 0.0477578483146413 GO:0032934 sterol binding 18/2813 68/18639 0.264705882352941 1.7539470107275 0.0104803806814636 0.0492893091447783 GO:0043548 phosphatidylinositol 3-kinase binding 9/2813 26/18639 0.346153846153846 2.29362301402828 0.0109689248999372 0.0513937267783572 GO:0005154 epidermal growth factor receptor binding 11/2813 35/18639 0.314285714285714 2.08246406987964 0.0114059179584299 0.052158545603538 GO:0016763 pentosyltransferase activity 14/2813 49/18639 0.285714285714286 1.89314915443604 0.011444993439816 0.052158545603538 GO:0060590 ATPase regulator activity 14/2813 49/18639 0.285714285714286 1.89314915443604 0.011444993439816 0.052158545603538 GO:0032931 histone H3K56 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0043992 histone H3K9 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0043993 histone H3K18 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0043994 histone H3K23 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0043999 histone H2AK5 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0044012 histone H2AK9 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0044014 histone H2BK5 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0044015 histone H2BK12 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0044016 histone H3K4 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0044017 histone H3K27 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0044018 histone H3K36 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0140908 histone H3K122 acetyltransferase activity 8/2813 22/18639 0.363636363636364 2.40946256019132 0.0117575618386872 0.052158545603538 GO:0017018 myosin phosphatase activity 21/2813 84/18639 0.25 1.65650551013153 0.0118527993668137 0.052256279548531 GO:0004721 phosphoprotein phosphatase activity 38/2813 175/18639 0.217142857142857 1.43879335737139 0.0118631362044627 0.052256279548531 GO:0003697 single-stranded DNA binding 28/2813 121/18639 0.231404958677686 1.53329435648539 0.0123128139234004 0.054046772695347 GO:0004532 RNA exonuclease activity 12/2813 40/18639 0.3 1.98780661215784 0.0124562129243016 0.0544850432458086 GO:0019003 GDP binding 19/2813 75/18639 0.253333333333333 1.67859225026662 0.0140475333464995 0.0612315826357871 GO:0140326 ATPase-coupled intramembrane lipid transporter activity 9/2813 27/18639 0.333333333333333 2.20867401350871 0.0142953220745461 0.0620953052613096 GO:0005525 GTP binding 73/2813 378/18639 0.193121693121693 1.27962859512806 0.0144261744406096 0.0624468658311507 GO:0044013 histone H2B acetyltransferase activity 8/2813 23/18639 0.347826086956522 2.30470331844387 0.0156906174664849 0.0676860774157677 GO:0001618 virus receptor activity 20/2813 81/18639 0.246913580246914 1.63605482482127 0.0158293307122513 0.0678167558939258 GO:0030971 receptor tyrosine kinase binding 20/2813 81/18639 0.246913580246914 1.63605482482127 0.0158293307122513 0.0678167558939258 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 47/2813 229/18639 0.205240174672489 1.35992592098135 0.0158897119222772 0.0678430592111068 GO:0030276 clathrin binding 13/2813 46/18639 0.282608695652174 1.87257144623564 0.0159439323805479 0.0678430592111068 GO:0140142 nucleocytoplasmic carrier activity 10/2813 32/18639 0.3125 2.07063188766442 0.0161973501883565 0.0680641784825208 GO:0004143 ATP-dependent diacylglycerol kinase activity 5/2813 11/18639 0.454545454545455 3.01182820023915 0.0162679371433043 0.0680641784825208 GO:0008526 phosphatidylinositol transfer activity 5/2813 11/18639 0.454545454545455 3.01182820023915 0.0162679371433043 0.0680641784825208 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding 5/2813 11/18639 0.454545454545455 3.01182820023915 0.0162679371433043 0.0680641784825208 GO:0042608 T cell receptor binding 5/2813 11/18639 0.454545454545455 3.01182820023915 0.0162679371433043 0.0680641784825208 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 7/2813 19/18639 0.368421052631579 2.44116601493068 0.0168108006763656 0.0701010388204446 GO:0019789 SUMO transferase activity 9/2813 28/18639 0.321428571428571 2.12979279874054 0.0183101612175943 0.0758477208053328 GO:0046875 ephrin receptor binding 9/2813 28/18639 0.321428571428571 2.12979279874054 0.0183101612175943 0.0758477208053328 GO:0048487 beta-tubulin binding 12/2813 42/18639 0.285714285714286 1.89314915443604 0.0184931187661624 0.0761016170278593 GO:0051879 Hsp90 protein binding 12/2813 42/18639 0.285714285714286 1.89314915443604 0.0184931187661624 0.0761016170278593 GO:0042277 peptide binding 50/2813 249/18639 0.200803212851406 1.33052651416187 0.019533682893946 0.0801201222961521 GO:0035091 phosphatidylinositol binding 56/2813 284/18639 0.197183098591549 1.30653955728684 0.0199634348179059 0.0816152188143802 GO:0001091 RNA polymerase II general transcription initiation factor binding 8/2813 24/18639 0.333333333333333 2.20867401350871 0.0204924931319591 0.0829647537478346 GO:0043998 histone H2A acetyltransferase activity 8/2813 24/18639 0.333333333333333 2.20867401350871 0.0204924931319591 0.0829647537478346 GO:0048027 mRNA 5'-UTR binding 8/2813 24/18639 0.333333333333333 2.20867401350871 0.0204924931319591 0.0829647537478346 GO:0016791 phosphatase activity 54/2813 273/18639 0.197802197802198 1.31064172230187 0.0207666599856192 0.0838035214258375 GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters 11/2813 38/18639 0.289473684210526 1.91805901173125 0.0214362545172962 0.0859511359010818 GO:0042162 telomeric DNA binding 11/2813 38/18639 0.289473684210526 1.91805901173125 0.0214362545172962 0.0859511359010818 GO:0016004 phospholipase activator activity 7/2813 20/18639 0.35 2.31910771418414 0.0225663368239825 0.0899060107222997 GO:0061608 nuclear import signal receptor activity 7/2813 20/18639 0.35 2.31910771418414 0.0225663368239825 0.0899060107222997 GO:0017116 single-stranded DNA helicase activity 15/2813 58/18639 0.258620689655172 1.71362638979124 0.0227085598978622 0.0901854235943671 GO:0004697 diacylglycerol-dependent serine/threonine kinase activity 6/2813 16/18639 0.375 2.4847582651973 0.024158126017754 0.0945093597068277 GO:0022858 alanine transmembrane transporter activity 6/2813 16/18639 0.375 2.4847582651973 0.024158126017754 0.0945093597068277 GO:0140327 flippase activity 6/2813 16/18639 0.375 2.4847582651973 0.024158126017754 0.0945093597068277 GO:0140328 floppase activity 6/2813 16/18639 0.375 2.4847582651973 0.024158126017754 0.0945093597068277 GO:0035014 phosphatidylinositol 3-kinase regulator activity 5/2813 12/18639 0.416666666666667 2.76084251688589 0.0244772442406172 0.0945093597068277 GO:0035197 siRNA binding 5/2813 12/18639 0.416666666666667 2.76084251688589 0.0244772442406172 0.0945093597068277 GO:0070410 co-SMAD binding 5/2813 12/18639 0.416666666666667 2.76084251688589 0.0244772442406172 0.0945093597068277 GO:1990247 N6-methyladenosine-containing RNA reader activity 5/2813 12/18639 0.416666666666667 2.76084251688589 0.0244772442406172 0.0945093597068277 GO:1990817 poly(A) RNA polymerase activity 5/2813 12/18639 0.416666666666667 2.76084251688589 0.0244772442406172 0.0945093597068277 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 10/2813 34/18639 0.294117647058824 1.94883001191945 0.024820004353744 0.0955379244508732 GO:0008080 N-acetyltransferase activity 17/2813 69/18639 0.246376811594203 1.63249818389774 0.0253168327256486 0.0971514041097741 GO:0004709 MAP kinase kinase kinase activity 8/2813 25/18639 0.32 2.12032705296836 0.0262501006986197 0.100424697168114 GO:0001223 transcription coactivator binding 12/2813 44/18639 0.272727272727273 1.80709692014349 0.0264848865584493 0.100706969862067 GO:0043014 alpha-tubulin binding 12/2813 44/18639 0.272727272727273 1.80709692014349 0.0264848865584493 0.100706969862067 GO:0015485 cholesterol binding 14/2813 54/18639 0.259259259259259 1.71785756606233 0.0266176555307305 0.100905112330133 GO:0005543 phospholipid binding 91/2813 497/18639 0.183098591549296 1.21321530319493 0.0267125591820467 0.100958947240908 GO:0016407 acetyltransferase activity 22/2813 96/18639 0.229166666666667 1.51846338428724 0.0271290277349382 0.102224137639782 GO:1901981 phosphatidylinositol phosphate binding 38/2813 185/18639 0.205405405405405 1.36102074345942 0.0274788756361095 0.103231451714033 GO:0008187 poly-pyrimidine tract binding 9/2813 30/18639 0.3 1.98780661215784 0.0286833448100623 0.106794239158893 GO:0031210 phosphatidylcholine binding 9/2813 30/18639 0.3 1.98780661215784 0.0286833448100623 0.106794239158893 GO:0035925 mRNA 3'-UTR AU-rich region binding 9/2813 30/18639 0.3 1.98780661215784 0.0286833448100623 0.106794239158893 GO:0005123 death receptor binding 7/2813 21/18639 0.333333333333333 2.20867401350871 0.0295493950749446 0.109367731475608 GO:0070182 DNA polymerase binding 7/2813 21/18639 0.333333333333333 2.20867401350871 0.0295493950749446 0.109367731475608 GO:0000175 3'-5'-RNA exonuclease activity 10/2813 35/18639 0.285714285714286 1.89314915443604 0.0301856389118697 0.111393021471236 GO:0050997 quaternary ammonium group binding 11/2813 40/18639 0.275 1.82215606114469 0.0310006647694505 0.113397168498779 GO:0061791 GTPase motor activity 11/2813 40/18639 0.275 1.82215606114469 0.0310006647694505 0.113397168498779 GO:1990606 membrane scission GTPase motor activity 11/2813 40/18639 0.275 1.82215606114469 0.0310006647694505 0.113397168498779 GO:0008168 methyltransferase activity 41/2813 204/18639 0.200980392156863 1.33170050814496 0.0314967424673965 0.114875874130359 GO:0140034 methylation-dependent protein binding 18/2813 76/18639 0.236842105263158 1.56932100959829 0.0317031883676725 0.115292699558018 GO:0046965 nuclear retinoid X receptor binding 6/2813 17/18639 0.352941176470588 2.33859601430334 0.0326801404011781 0.118158542317554 GO:0051787 misfolded protein binding 6/2813 17/18639 0.352941176470588 2.33859601430334 0.0326801404011781 0.118158542317554 GO:0070412 R-SMAD binding 8/2813 26/18639 0.307692307692308 2.03877601246958 0.0330417343869231 0.119121641838734 GO:0004535 poly(A)-specific ribonuclease activity 5/2813 13/18639 0.384615384615385 2.54847001558697 0.0349348887061023 0.124867273632383 GO:0097157 pre-mRNA intronic binding 5/2813 13/18639 0.384615384615385 2.54847001558697 0.0349348887061023 0.124867273632383 GO:0140333 glycerophospholipid flippase activity 5/2813 13/18639 0.384615384615385 2.54847001558697 0.0349348887061023 0.124867273632383 GO:0005164 tumor necrosis factor receptor binding 9/2813 31/18639 0.290322580645161 1.92368381821726 0.0351681998932571 0.125068025042578 GO:0051213 dioxygenase activity 21/2813 93/18639 0.225806451612903 1.49619852528009 0.0351910030495504 0.125068025042578 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 7/2813 22/18639 0.318181818181818 2.1082797401674 0.037852250585198 0.133766004186674 GO:0046972 histone H4K16 acetyltransferase activity 7/2813 22/18639 0.318181818181818 2.1082797401674 0.037852250585198 0.133766004186674 GO:0001671 ATPase activator activity 8/2813 27/18639 0.296296296296296 1.96326578978552 0.0409349606237134 0.143563643828247 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity 20/2813 89/18639 0.224719101123595 1.48899371697216 0.0409690014761664 0.143563643828247 GO:0030946 protein tyrosine phosphatase activity, metal-dependent 20/2813 89/18639 0.224719101123595 1.48899371697216 0.0409690014761664 0.143563643828247 GO:0070717 poly-purine tract binding 9/2813 32/18639 0.28125 1.86356869889797 0.04259157586474 0.148368545361158 GO:0120015 sterol transfer activity 9/2813 32/18639 0.28125 1.86356869889797 0.04259157586474 0.148368545361158 GO:0000900 mRNA regulatory element binding translation repressor activity 6/2813 18/18639 0.333333333333333 2.20867401350871 0.04293318418924 0.148368545361158 GO:0004706 JUN kinase kinase kinase activity 6/2813 18/18639 0.333333333333333 2.20867401350871 0.04293318418924 0.148368545361158 GO:0008525 phosphatidylcholine transporter activity 6/2813 18/18639 0.333333333333333 2.20867401350871 0.04293318418924 0.148368545361158 GO:0031492 nucleosomal DNA binding 11/2813 42/18639 0.261904761904762 1.7353867248997 0.0432633524938219 0.149097669338213 GO:0042578 phosphoric ester hydrolase activity 67/2813 363/18639 0.184573002754821 1.22298478433953 0.0440921444387883 0.151536463442099 GO:0051015 actin filament binding 41/2813 209/18639 0.196172248803828 1.29984164431374 0.0443835623079935 0.152120099855616 GO:0140793 histone H2AXY142 phosphatase activity 20/2813 90/18639 0.222222222222222 1.47244934233914 0.0454691952602067 0.155415200192674 GO:0019001 guanyl nucleotide binding 73/2813 400/18639 0.1825 1.20924902239602 0.0459286841705111 0.156132564938341 GO:0032561 guanyl ribonucleotide binding 73/2813 400/18639 0.1825 1.20924902239602 0.0459286841705111 0.156132564938341 GO:0035064 methylated histone binding 17/2813 74/18639 0.22972972972973 1.5221942525533 0.0469321883858691 0.159111565503312 GO:0005158 insulin receptor binding 7/2813 23/18639 0.304347826086957 2.01661540363839 0.0475479650746351 0.160622741040248 GO:0005161 platelet-derived growth factor receptor binding 5/2813 14/18639 0.357142857142857 2.36643644304505 0.047763117239786 0.160622741040248 GO:0032454 histone H3K9 demethylase activity 5/2813 14/18639 0.357142857142857 2.36643644304505 0.047763117239786 0.160622741040248 GO:0051018 protein kinase A binding 13/2813 53/18639 0.245283018867925 1.62525068918565 0.0482147416285755 0.161706814416483 GO:0051959 dynein light intermediate chain binding 8/2813 28/18639 0.285714285714286 1.89314915443604 0.049984880386161 0.167195415409325 GO:0016303 1-phosphatidylinositol-3-kinase activity 4/2813 10/18639 0.4 2.65040881621045 0.0509118029079315 0.167952034911125 GO:0031996 thioesterase binding 4/2813 10/18639 0.4 2.65040881621045 0.0509118029079315 0.167952034911125 GO:0032395 MHC class II receptor activity 4/2813 10/18639 0.4 2.65040881621045 0.0509118029079315 0.167952034911125 GO:0042975 peroxisome proliferator activated receptor binding 4/2813 10/18639 0.4 2.65040881621045 0.0509118029079315 0.167952034911125 GO:0050815 phosphoserine residue binding 4/2813 10/18639 0.4 2.65040881621045 0.0509118029079315 0.167952034911125 GO:0044325 transmembrane transporter binding 28/2813 136/18639 0.205882352941176 1.36418100834361 0.0510166053287189 0.167952034911125 GO:0004879 nuclear receptor activity 14/2813 59/18639 0.23728813559322 1.57227641639603 0.0530957800062747 0.174338112304067 GO:0003925 G protein activity 13/2813 54/18639 0.240740740740741 1.59515345420073 0.055062598196185 0.180322801946145 GO:0004725 protein tyrosine phosphatase activity 21/2813 98/18639 0.214285714285714 1.41986186582703 0.0578818633155368 0.189060603153359 GO:0035035 histone acetyltransferase binding 7/2813 24/18639 0.291666666666667 1.93258976182012 0.0586884535216193 0.190699364559859 GO:0060229 lipase activator activity 7/2813 24/18639 0.291666666666667 1.93258976182012 0.0586884535216193 0.190699364559859 GO:0098531 ligand-modulated transcription factor activity 14/2813 60/18639 0.233333333333333 1.5460718094561 0.0600148996367092 0.194504247268195 GO:0106222 lncRNA binding 8/2813 29/18639 0.275862068965517 1.82786814911066 0.0602328005599111 0.194706029716922 GO:0000774 adenyl-nucleotide exchange factor activity 5/2813 15/18639 0.333333333333333 2.20867401350871 0.0630149683541048 0.201101340334146 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity 5/2813 15/18639 0.333333333333333 2.20867401350871 0.0630149683541048 0.201101340334146 GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity 5/2813 15/18639 0.333333333333333 2.20867401350871 0.0630149683541048 0.201101340334146 GO:0047372 monoacylglycerol lipase activity 5/2813 15/18639 0.333333333333333 2.20867401350871 0.0630149683541048 0.201101340334146 GO:0120283 protein serine/threonine kinase binding 5/2813 15/18639 0.333333333333333 2.20867401350871 0.0630149683541048 0.201101340334146 GO:0016741 transferase activity, transferring one-carbon groups 41/2813 215/18639 0.190697674418605 1.26356699377475 0.0646478724235121 0.205787502294691 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding 4/2813 11/18639 0.363636363636364 2.40946256019132 0.0707082976305756 0.221140200839625 GO:0003953 NAD+ nucleosidase activity 4/2813 11/18639 0.363636363636364 2.40946256019132 0.0707082976305756 0.221140200839625 GO:0008432 JUN kinase binding 4/2813 11/18639 0.363636363636364 2.40946256019132 0.0707082976305756 0.221140200839625 GO:0015173 aromatic amino acid transmembrane transporter activity 4/2813 11/18639 0.363636363636364 2.40946256019132 0.0707082976305756 0.221140200839625 GO:0043522 leucine zipper domain binding 4/2813 11/18639 0.363636363636364 2.40946256019132 0.0707082976305756 0.221140200839625 GO:0140537 transcription regulator activator activity 4/2813 11/18639 0.363636363636364 2.40946256019132 0.0707082976305756 0.221140200839625 GO:0180030 inositol phosphate kinase activity 4/2813 11/18639 0.363636363636364 2.40946256019132 0.0707082976305756 0.221140200839625 GO:0043015 gamma-tubulin binding 9/2813 35/18639 0.257142857142857 1.70383423899243 0.0708882575316027 0.22115015005495 GO:0017025 TBP-class protein binding 7/2813 25/18639 0.28 1.85528617134732 0.0713033685083413 0.221341225816216 GO:0017056 structural constituent of nuclear pore 7/2813 25/18639 0.28 1.85528617134732 0.0713033685083413 0.221341225816216 GO:0001968 fibronectin binding 8/2813 30/18639 0.266666666666667 1.76693921080697 0.0717053299234925 0.221489796874788 GO:0031624 ubiquitin conjugating enzyme binding 8/2813 30/18639 0.266666666666667 1.76693921080697 0.0717053299234925 0.221489796874788 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 85/2813 484/18639 0.175619834710744 1.16366089554694 0.0723336076803065 0.222880155684885 GO:0005548 phospholipid transporter activity 15/2813 68/18639 0.220588235294118 1.46162250893959 0.0799410530831153 0.243197925155468 GO:0030145 manganese ion binding 15/2813 68/18639 0.220588235294118 1.46162250893959 0.0799410530831153 0.243197925155468 GO:0004707 MAP kinase activity 5/2813 16/18639 0.3125 2.07063188766442 0.0806771694160825 0.243197925155468 GO:0005159 insulin-like growth factor receptor binding 5/2813 16/18639 0.3125 2.07063188766442 0.0806771694160825 0.243197925155468 GO:0005521 lamin binding 5/2813 16/18639 0.3125 2.07063188766442 0.0806771694160825 0.243197925155468 GO:0008142 oxysterol binding 5/2813 16/18639 0.3125 2.07063188766442 0.0806771694160825 0.243197925155468 GO:0017070 U6 snRNA binding 5/2813 16/18639 0.3125 2.07063188766442 0.0806771694160825 0.243197925155468 GO:0034450 ubiquitin-ubiquitin ligase activity 5/2813 16/18639 0.3125 2.07063188766442 0.0806771694160825 0.243197925155468 GO:0070411 I-SMAD binding 5/2813 16/18639 0.3125 2.07063188766442 0.0806771694160825 0.243197925155468 GO:0005484 SNAP receptor activity 9/2813 36/18639 0.25 1.65650551013153 0.0824108937781409 0.247232681334423 GO:0044390 ubiquitin-like protein conjugating enzyme binding 9/2813 36/18639 0.25 1.65650551013153 0.0824108937781409 0.247232681334423 GO:0005080 protein kinase C binding 12/2813 52/18639 0.230769230769231 1.52908200935218 0.0833655620821138 0.24949836881513 GO:0005496 steroid binding 22/2813 108/18639 0.203703703703704 1.34974523047754 0.0841676076795841 0.250851520950037 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity 6/2813 21/18639 0.285714285714286 1.89314915443604 0.0846197776506121 0.250851520950037 GO:0008373 sialyltransferase activity 6/2813 21/18639 0.285714285714286 1.89314915443604 0.0846197776506121 0.250851520950037 GO:0140312 cargo adaptor activity 6/2813 21/18639 0.285714285714286 1.89314915443604 0.0846197776506121 0.250851520950037 GO:0008143 poly(A) binding 7/2813 26/18639 0.269230769230769 1.78392901091088 0.0853997600267585 0.251376705396412 GO:0034237 protein kinase A regulatory subunit binding 7/2813 26/18639 0.269230769230769 1.78392901091088 0.0853997600267585 0.251376705396412 GO:0120014 phospholipid transfer activity 7/2813 26/18639 0.269230769230769 1.78392901091088 0.0853997600267585 0.251376705396412 GO:0005126 cytokine receptor binding 50/2813 275/18639 0.181818181818182 1.20473128009566 0.0896322321237313 0.263215780250676 GO:0043178 alcohol binding 19/2813 92/18639 0.206521739130435 1.36841759532605 0.092482559597458 0.270950075073583 GO:0001216 DNA-binding transcription activator activity 85/2813 491/18639 0.173116089613035 1.14707102534566 0.0936245915329412 0.271070679517942 GO:0016251 RNA polymerase II general transcription initiation factor activity 12/2813 53/18639 0.226415094339623 1.50023140540214 0.0936536070929053 0.271070679517942 GO:0004126 cytidine deaminase activity 4/2813 12/18639 0.333333333333333 2.20867401350871 0.0938238243255546 0.271070679517942 GO:0005527 macrolide binding 4/2813 12/18639 0.333333333333333 2.20867401350871 0.0938238243255546 0.271070679517942 GO:0016273 arginine N-methyltransferase activity 4/2813 12/18639 0.333333333333333 2.20867401350871 0.0938238243255546 0.271070679517942 GO:0016274 protein-arginine N-methyltransferase activity 4/2813 12/18639 0.333333333333333 2.20867401350871 0.0938238243255546 0.271070679517942 GO:0030515 snoRNA binding 8/2813 32/18639 0.25 1.65650551013153 0.0983546705657945 0.283506204787578 GO:0008429 phosphatidylethanolamine binding 5/2813 17/18639 0.294117647058824 1.94883001191945 0.100675931505626 0.2895300926748 GO:0008266 poly(U) RNA binding 7/2813 27/18639 0.259259259259259 1.71785756606233 0.100962439817824 0.289688101403895 GO:0034062 5'-3' RNA polymerase activity 6/2813 22/18639 0.272727272727273 1.80709692014349 0.102157600300142 0.291114255069426 GO:0061133 endopeptidase activator activity 6/2813 22/18639 0.272727272727273 1.80709692014349 0.102157600300142 0.291114255069426 GO:0097747 RNA polymerase activity 6/2813 22/18639 0.272727272727273 1.80709692014349 0.102157600300142 0.291114255069426 GO:0043531 ADP binding 9/2813 38/18639 0.236842105263158 1.56932100959829 0.108625625985796 0.308842404791434 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 13/2813 60/18639 0.216666666666667 1.43563810878066 0.109794705610078 0.31145845060818 GO:0019239 deaminase activity 8/2813 33/18639 0.242424242424242 1.60630837346088 0.113508854216525 0.321266010463513 GO:0002020 protease binding 26/2813 136/18639 0.191176470588235 1.26673950774764 0.117686942504972 0.332339424545643 GO:0005319 lipid transporter activity 33/2813 178/18639 0.185393258426966 1.22841981650204 0.119425742990941 0.335080027758224 GO:0019855 calcium channel inhibitor activity 4/2813 13/18639 0.307692307692308 2.03877601246958 0.119996684600867 0.335080027758224 GO:0043560 insulin receptor substrate binding 4/2813 13/18639 0.307692307692308 2.03877601246958 0.119996684600867 0.335080027758224 GO:0046974 histone H3K9 methyltransferase activity 4/2813 13/18639 0.307692307692308 2.03877601246958 0.119996684600867 0.335080027758224 GO:0140410 monoatomic cation:bicarbonate symporter activity 4/2813 13/18639 0.307692307692308 2.03877601246958 0.119996684600867 0.335080027758224 GO:0042171 lysophosphatidic acid acyltransferase activity 6/2813 23/18639 0.260869565217391 1.7285274888329 0.121431589203263 0.33757981798507 GO:0071617 lysophospholipid acyltransferase activity 6/2813 23/18639 0.260869565217391 1.7285274888329 0.121431589203263 0.33757981798507 GO:0035615 clathrin adaptor activity 5/2813 18/18639 0.277777777777778 1.84056167792392 0.122884680473466 0.340107821398908 GO:0050811 GABA receptor binding 5/2813 18/18639 0.277777777777778 1.84056167792392 0.122884680473466 0.340107821398908 GO:0000217 DNA secondary structure binding 9/2813 39/18639 0.230769230769231 1.52908200935218 0.123290887012734 0.340478807180861 GO:0046982 protein heterodimerization activity 64/2813 369/18639 0.173441734417344 1.1492287549964 0.12655656593128 0.34872745370051 GO:0008376 acetylgalactosaminyltransferase activity 8/2813 34/18639 0.235294117647059 1.55906400953556 0.129843310933447 0.356997762588444 GO:0140303 intramembrane lipid transporter activity 10/2813 45/18639 0.222222222222222 1.47244934233914 0.131015562768916 0.359430853122617 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 7/2813 29/18639 0.241379310344828 1.59938463047182 0.136321101150164 0.371541824703388 GO:0035250 UDP-galactosyltransferase activity 7/2813 29/18639 0.241379310344828 1.59938463047182 0.136321101150164 0.371541824703388 GO:0097472 cyclin-dependent protein kinase activity 7/2813 29/18639 0.241379310344828 1.59938463047182 0.136321101150164 0.371541824703388 GO:0140223 general transcription initiation factor activity 14/2813 68/18639 0.205882352941176 1.36418100834361 0.136979798490418 0.372245808219555 GO:0030544 Hsp70 protein binding 11/2813 51/18639 0.215686274509804 1.42914200874093 0.137174514459804 0.372245808219555 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 9/2813 40/18639 0.225 1.49085495911838 0.138959367873085 0.37627309352647 GO:0016504 peptidase activator activity 12/2813 57/18639 0.210526315789474 1.39495200853182 0.14211759106448 0.382956571338767 GO:0050699 WW domain binding 6/2813 24/18639 0.25 1.65650551013153 0.14234596776381 0.382956571338767 GO:0070300 phosphatidic acid binding 6/2813 24/18639 0.25 1.65650551013153 0.14234596776381 0.382956571338767 GO:0015355 secondary active monocarboxylate transmembrane transporter activity 5/2813 19/18639 0.263157894736842 1.74369001066477 0.14713289889703 0.392129535880356 GO:0046624 sphingolipid transporter activity 5/2813 19/18639 0.263157894736842 1.74369001066477 0.14713289889703 0.392129535880356 GO:0004705 JUN kinase activity 4/2813 14/18639 0.285714285714286 1.89314915443604 0.148890111545299 0.392129535880356 GO:0008174 mRNA methyltransferase activity 4/2813 14/18639 0.285714285714286 1.89314915443604 0.148890111545299 0.392129535880356 GO:0019992 diacylglycerol binding 4/2813 14/18639 0.285714285714286 1.89314915443604 0.148890111545299 0.392129535880356 GO:0030983 mismatched DNA binding 4/2813 14/18639 0.285714285714286 1.89314915443604 0.148890111545299 0.392129535880356 GO:0042043 neurexin family protein binding 4/2813 14/18639 0.285714285714286 1.89314915443604 0.148890111545299 0.392129535880356 GO:0046030 inositol trisphosphate phosphatase activity 4/2813 14/18639 0.285714285714286 1.89314915443604 0.148890111545299 0.392129535880356 GO:0071933 Arp2/3 complex binding 4/2813 14/18639 0.285714285714286 1.89314915443604 0.148890111545299 0.392129535880356 GO:1990825 sequence-specific mRNA binding 4/2813 14/18639 0.285714285714286 1.89314915443604 0.148890111545299 0.392129535880356 GO:0015101 organic cation transmembrane transporter activity 16/2813 81/18639 0.197530864197531 1.30884385985701 0.15396169259 0.40463461644977 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding 9/2813 41/18639 0.219512195121951 1.45449264304232 0.155592228187433 0.406540521016814 GO:0015175 neutral L-amino acid transmembrane transporter activity 9/2813 41/18639 0.219512195121951 1.45449264304232 0.155592228187433 0.406540521016814 GO:0001965 G-protein alpha-subunit binding 7/2813 30/18639 0.233333333333333 1.5460718094561 0.155986770653933 0.406540521016814 GO:0070566 adenylyltransferase activity 7/2813 30/18639 0.233333333333333 1.5460718094561 0.155986770653933 0.406540521016814 GO:0015662 P-type ion transporter activity 6/2813 25/18639 0.24 1.59024528972627 0.164780472791853 0.426045127519895 GO:0120020 cholesterol transfer activity 6/2813 25/18639 0.24 1.59024528972627 0.164780472791853 0.426045127519895 GO:0140358 P-type transmembrane transporter activity 6/2813 25/18639 0.24 1.59024528972627 0.164780472791853 0.426045127519895 GO:0055106 ubiquitin-protein transferase regulator activity 8/2813 36/18639 0.222222222222222 1.47244934233914 0.165854498083284 0.426045127519895 GO:0140838 RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity 8/2813 36/18639 0.222222222222222 1.47244934233914 0.165854498083284 0.426045127519895 GO:0140839 RNA polymerase II CTD heptapeptide repeat P3 isomerase activity 8/2813 36/18639 0.222222222222222 1.47244934233914 0.165854498083284 0.426045127519895 GO:0140840 RNA polymerase II CTD heptapeptide repeat P6 isomerase activity 8/2813 36/18639 0.222222222222222 1.47244934233914 0.165854498083284 0.426045127519895 GO:0003899 DNA-directed 5'-3' RNA polymerase activity 5/2813 20/18639 0.25 1.65650551013153 0.173215404319709 0.440761912770527 GO:0015095 magnesium ion transmembrane transporter activity 5/2813 20/18639 0.25 1.65650551013153 0.173215404319709 0.440761912770527 GO:0140939 histone H4 methyltransferase activity 5/2813 20/18639 0.25 1.65650551013153 0.173215404319709 0.440761912770527 GO:0016411 acylglycerol O-acyltransferase activity 7/2813 31/18639 0.225806451612903 1.49619852528009 0.176862192168259 0.440761912770527 GO:0070325 lipoprotein particle receptor binding 7/2813 31/18639 0.225806451612903 1.49619852528009 0.176862192168259 0.440761912770527 GO:0004953 icosanoid receptor activity 4/2813 15/18639 0.266666666666667 1.76693921080697 0.180117436342097 0.440761912770527 GO:0010181 FMN binding 4/2813 15/18639 0.266666666666667 1.76693921080697 0.180117436342097 0.440761912770527 GO:0051371 muscle alpha-actinin binding 4/2813 15/18639 0.266666666666667 1.76693921080697 0.180117436342097 0.440761912770527 GO:0140776 protein-containing complex destabilizing activity 4/2813 15/18639 0.266666666666667 1.76693921080697 0.180117436342097 0.440761912770527 GO:0141050 histone H3K deacetylase activity 4/2813 15/18639 0.266666666666667 1.76693921080697 0.180117436342097 0.440761912770527 GO:0141051 histone H4K deacetylase activity 4/2813 15/18639 0.266666666666667 1.76693921080697 0.180117436342097 0.440761912770527 GO:0001094 TFIID-class transcription factor complex binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0003680 minor groove of adenine-thymine-rich DNA binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0004445 inositol-polyphosphate 5-phosphatase activity 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0004862 cAMP-dependent protein kinase inhibitor activity 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0005031 tumor necrosis factor receptor activity 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0005131 growth hormone receptor binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0005522 profilin binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0005528 FK506 binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0008140 cAMP response element binding protein binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0015658 branched-chain amino acid transmembrane transporter activity 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0031078 histone H3K14 deacetylase activity, hydrolytic mechanism 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0034739 histone H4K16 deacetylase activity, hydrolytic mechanism 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0051880 G-quadruplex DNA binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0070513 death domain binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0180032 histone H4K5 deacetylase activity, hydrolytic mechanism 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0180033 histone H4K8 deacetylase activity, hydrolytic mechanism 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:1905394 retromer complex binding 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:1990162 histone H3K4 deacetylase activity, hydrolytic mechanism 3/2813 10/18639 0.3 1.98780661215784 0.182153404398371 0.440761912770527 GO:0016757 glycosyltransferase activity 46/2813 267/18639 0.172284644194757 1.14156184967866 0.183974719119818 0.444309601580872 GO:0042805 actinin binding 8/2813 37/18639 0.216216216216216 1.43265341416781 0.18540258077388 0.446295601479458 GO:0140375 immune receptor activity 28/2813 156/18639 0.179487179487179 1.18928600727392 0.185510561766042 0.446295601479458 GO:0004527 exonuclease activity 16/2813 84/18639 0.19047619047619 1.26209943629069 0.191554501068024 0.459951402756427 GO:0004896 cytokine receptor activity 18/2813 96/18639 0.1875 1.24237913259865 0.192113697163349 0.460410412167336 GO:0008378 galactosyltransferase activity 7/2813 32/18639 0.21875 1.44944232136509 0.19884429821695 0.474721788300389 GO:0031369 translation initiation factor binding 7/2813 32/18639 0.21875 1.44944232136509 0.19884429821695 0.474721788300389 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 5/2813 21/18639 0.238095238095238 1.57762429536336 0.200901537653801 0.478719664009343 GO:0004857 enzyme inhibitor activity 69/2813 416/18639 0.165865384615385 1.09902769422188 0.212507771345867 0.503303619113786 GO:0030275 LRR domain binding 4/2813 16/18639 0.25 1.65650551013153 0.213264191984102 0.503303619113786 GO:0055102 lipase inhibitor activity 4/2813 16/18639 0.25 1.65650551013153 0.213264191984102 0.503303619113786 GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating 4/2813 16/18639 0.25 1.65650551013153 0.213264191984102 0.503303619113786 GO:0097027 ubiquitin-protein transferase activator activity 4/2813 16/18639 0.25 1.65650551013153 0.213264191984102 0.503303619113786 GO:0004683 calcium/calmodulin-dependent protein kinase activity 6/2813 27/18639 0.222222222222222 1.47244934233914 0.213632471422398 0.503303619113786 GO:0015179 L-amino acid transmembrane transporter activity 12/2813 62/18639 0.193548387096774 1.28245587881151 0.217904468525373 0.512403176927145 GO:0030296 protein tyrosine kinase activator activity 7/2813 33/18639 0.212121212121212 1.40551982677827 0.221819225447833 0.516892240986725 GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding 3/2813 11/18639 0.272727272727273 1.80709692014349 0.223945319436295 0.516892240986725 GO:0008172 S-methyltransferase activity 3/2813 11/18639 0.272727272727273 1.80709692014349 0.223945319436295 0.516892240986725 GO:0010854 adenylate cyclase regulator activity 3/2813 11/18639 0.272727272727273 1.80709692014349 0.223945319436295 0.516892240986725 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor 3/2813 11/18639 0.272727272727273 1.80709692014349 0.223945319436295 0.516892240986725 GO:0019107 myristoyltransferase activity 3/2813 11/18639 0.272727272727273 1.80709692014349 0.223945319436295 0.516892240986725 GO:0032129 histone H3K9 deacetylase activity, hydrolytic mechanism 3/2813 11/18639 0.272727272727273 1.80709692014349 0.223945319436295 0.516892240986725 GO:0034511 U3 snoRNA binding 3/2813 11/18639 0.272727272727273 1.80709692014349 0.223945319436295 0.516892240986725 GO:0140031 phosphorylation-dependent protein binding 3/2813 11/18639 0.272727272727273 1.80709692014349 0.223945319436295 0.516892240986725 GO:0140937 histone H4K12 deacetylase activity, hydrolytic mechanism 3/2813 11/18639 0.272727272727273 1.80709692014349 0.223945319436295 0.516892240986725 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 8/2813 39/18639 0.205128205128205 1.35918400831305 0.227188834963726 0.523412951270021 GO:0004407 histone deacetylase activity 5/2813 22/18639 0.227272727272727 1.50591410011957 0.229943872169583 0.525886259751642 GO:0008970 phospholipase A1 activity 5/2813 22/18639 0.227272727272727 1.50591410011957 0.229943872169583 0.525886259751642 GO:0033558 protein lysine deacetylase activity 5/2813 22/18639 0.227272727272727 1.50591410011957 0.229943872169583 0.525886259751642 GO:0140517 protein-RNA adaptor activity 5/2813 22/18639 0.227272727272727 1.50591410011957 0.229943872169583 0.525886259751642 GO:0008009 chemokine activity 9/2813 45/18639 0.2 1.32520440810523 0.230695212905271 0.526641809022799 GO:0015035 protein-disulfide reductase activity 7/2813 34/18639 0.205882352941176 1.36418100834361 0.245664832914526 0.556798211378965 GO:0052866 phosphatidylinositol phosphate phosphatase activity 7/2813 34/18639 0.205882352941176 1.36418100834361 0.245664832914526 0.556798211378965 GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity 4/2813 17/18639 0.235294117647059 1.55906400953556 0.247906733669787 0.556798211378965 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 4/2813 17/18639 0.235294117647059 1.55906400953556 0.247906733669787 0.556798211378965 GO:0005092 GDP-dissociation inhibitor activity 4/2813 17/18639 0.235294117647059 1.55906400953556 0.247906733669787 0.556798211378965 GO:0030169 low-density lipoprotein particle binding 4/2813 17/18639 0.235294117647059 1.55906400953556 0.247906733669787 0.556798211378965 GO:0038191 neuropilin binding 4/2813 17/18639 0.235294117647059 1.55906400953556 0.247906733669787 0.556798211378965 GO:0070403 NAD+ binding 4/2813 17/18639 0.235294117647059 1.55906400953556 0.247906733669787 0.556798211378965 GO:0004177 aminopeptidase activity 8/2813 40/18639 0.2 1.32520440810523 0.249246201736387 0.556798211378965 GO:0015036 disulfide oxidoreductase activity 8/2813 40/18639 0.2 1.32520440810523 0.249246201736387 0.556798211378965 GO:0030331 nuclear estrogen receptor binding 8/2813 40/18639 0.2 1.32520440810523 0.249246201736387 0.556798211378965 GO:0071949 FAD binding 8/2813 40/18639 0.2 1.32520440810523 0.249246201736387 0.556798211378965 GO:0008408 3'-5' exonuclease activity 11/2813 58/18639 0.189655172413793 1.25665935251358 0.252498102177326 0.563057265283128 GO:0003887 DNA-directed DNA polymerase activity 5/2813 23/18639 0.217391304347826 1.44043957402742 0.260086172993561 0.576893266693165 GO:0017134 fibroblast growth factor binding 5/2813 23/18639 0.217391304347826 1.44043957402742 0.260086172993561 0.576893266693165 GO:0043274 phospholipase binding 5/2813 23/18639 0.217391304347826 1.44043957402742 0.260086172993561 0.576893266693165 GO:0030165 PDZ domain binding 15/2813 83/18639 0.180722891566265 1.19747386274569 0.264742571907812 0.583623487043602 GO:0004000 adenosine deaminase activity 3/2813 12/18639 0.25 1.65650551013153 0.267319151139875 0.583623487043602 GO:0005049 nuclear export signal receptor activity 3/2813 12/18639 0.25 1.65650551013153 0.267319151139875 0.583623487043602 GO:0008603 cAMP-dependent protein kinase regulator activity 3/2813 12/18639 0.25 1.65650551013153 0.267319151139875 0.583623487043602 GO:0017166 vinculin binding 3/2813 12/18639 0.25 1.65650551013153 0.267319151139875 0.583623487043602 GO:0034452 dynactin binding 3/2813 12/18639 0.25 1.65650551013153 0.267319151139875 0.583623487043602 GO:0035251 UDP-glucosyltransferase activity 3/2813 12/18639 0.25 1.65650551013153 0.267319151139875 0.583623487043602 GO:0070679 inositol 1,4,5 trisphosphate binding 3/2813 12/18639 0.25 1.65650551013153 0.267319151139875 0.583623487043602 GO:0141221 histone deacetylase activity, hydrolytic mechanism 3/2813 12/18639 0.25 1.65650551013153 0.267319151139875 0.583623487043602 GO:0019843 rRNA binding 12/2813 65/18639 0.184615384615385 1.22326560748175 0.270007755127526 0.588466379206507 GO:0042169 SH2 domain binding 8/2813 41/18639 0.195121951219512 1.29288234937095 0.271950195324012 0.591065225467042 GO:0005246 calcium channel regulator activity 10/2813 53/18639 0.188679245283019 1.25019283783512 0.272145139783386 0.591065225467042 GO:0004540 RNA nuclease activity 21/2813 121/18639 0.173553719008264 1.14997076736404 0.277611349375877 0.601892197693627 GO:0008308 voltage-gated monoatomic anion channel activity 4/2813 18/18639 0.222222222222222 1.47244934233914 0.283627320297307 0.608606822799196 GO:0008409 5'-3' exonuclease activity 4/2813 18/18639 0.222222222222222 1.47244934233914 0.283627320297307 0.608606822799196 GO:0031690 adrenergic receptor binding 4/2813 18/18639 0.222222222222222 1.47244934233914 0.283627320297307 0.608606822799196 GO:0052744 phosphatidylinositol monophosphate phosphatase activity 4/2813 18/18639 0.222222222222222 1.47244934233914 0.283627320297307 0.608606822799196 GO:0070064 proline-rich region binding 4/2813 18/18639 0.222222222222222 1.47244934233914 0.283627320297307 0.608606822799196 GO:0070628 proteasome binding 4/2813 18/18639 0.222222222222222 1.47244934233914 0.283627320297307 0.608606822799196 GO:0005315 phosphate transmembrane transporter activity 5/2813 24/18639 0.208333333333333 1.38042125844294 0.291070437527706 0.622442935636171 GO:0030552 cAMP binding 5/2813 24/18639 0.208333333333333 1.38042125844294 0.291070437527706 0.622442935636171 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 10/2813 54/18639 0.185185185185185 1.22704111861595 0.292478307429626 0.623322593857687 GO:0051287 NAD binding 10/2813 54/18639 0.185185185185185 1.22704111861595 0.292478307429626 0.623322593857687 GO:0015215 nucleotide transmembrane transporter activity 6/2813 30/18639 0.2 1.32520440810523 0.294380329243206 0.626309169869474 GO:0016859 cis-trans isomerase activity 8/2813 42/18639 0.19047619047619 1.26209943629069 0.2951992654326 0.626460200658075 GO:0016409 palmitoyltransferase activity 7/2813 36/18639 0.194444444444444 1.28839317454675 0.295452852428668 0.626460200658075 GO:0005035 death receptor activity 3/2813 13/18639 0.230769230769231 1.52908200935218 0.311515891101578 0.656071346410898 GO:0005172 vascular endothelial growth factor receptor binding 3/2813 13/18639 0.230769230769231 1.52908200935218 0.311515891101578 0.656071346410898 GO:0030955 potassium ion binding 3/2813 13/18639 0.230769230769231 1.52908200935218 0.311515891101578 0.656071346410898 GO:0061459 L-arginine transmembrane transporter activity 3/2813 13/18639 0.230769230769231 1.52908200935218 0.311515891101578 0.656071346410898 GO:0035254 glutamate receptor binding 9/2813 49/18639 0.183673469387755 1.21702445642317 0.316184014233794 0.664783532447859 GO:0000049 tRNA binding 14/2813 80/18639 0.175 1.15955385709207 0.317369983991214 0.666157466397667 GO:0031420 alkali metal ion binding 4/2813 19/18639 0.210526315789474 1.39495200853182 0.320025832670715 0.66948547938305 GO:0042577 lipid phosphatase activity 4/2813 19/18639 0.210526315789474 1.39495200853182 0.320025832670715 0.66948547938305 GO:0008327 methyl-CpG binding 6/2813 31/18639 0.193548387096774 1.28245587881151 0.322584682141193 0.671591187717634 GO:0047499 calcium-independent phospholipase A2 activity 6/2813 31/18639 0.193548387096774 1.28245587881151 0.322584682141193 0.671591187717634 GO:0003707 nuclear steroid receptor activity 5/2813 25/18639 0.2 1.32520440810523 0.322642928711669 0.671591187717634 GO:0019212 phosphatase inhibitor activity 10/2813 56/18639 0.178571428571429 1.18321822152252 0.334235220486495 0.694565217323265 GO:0015605 organophosphate ester transmembrane transporter activity 9/2813 50/18639 0.18 1.1926839672947 0.338584285535289 0.701273081464647 GO:0048020 CCR chemokine receptor binding 9/2813 50/18639 0.18 1.1926839672947 0.338584285535289 0.701273081464647 GO:0008194 UDP-glycosyltransferase activity 24/2813 145/18639 0.16551724137931 1.09672088946639 0.344876219439686 0.71061668493287 GO:0070851 growth factor receptor binding 23/2813 139/18639 0.165467625899281 1.09639213620217 0.349937101253775 0.71061668493287 GO:0047498 calcium-dependent phospholipase A2 activity 6/2813 32/18639 0.1875 1.24237913259865 0.35114015535448 0.71061668493287 GO:0071813 lipoprotein particle binding 6/2813 32/18639 0.1875 1.24237913259865 0.35114015535448 0.71061668493287 GO:0071814 protein-lipid complex binding 6/2813 32/18639 0.1875 1.24237913259865 0.35114015535448 0.71061668493287 GO:0005112 Notch binding 5/2813 26/18639 0.192307692307692 1.27423500779349 0.354559176828404 0.71061668493287 GO:0005160 transforming growth factor beta receptor binding 5/2813 26/18639 0.192307692307692 1.27423500779349 0.354559176828404 0.71061668493287 GO:0050750 low-density lipoprotein particle receptor binding 5/2813 26/18639 0.192307692307692 1.27423500779349 0.354559176828404 0.71061668493287 GO:0070006 metalloaminopeptidase activity 5/2813 26/18639 0.192307692307692 1.27423500779349 0.354559176828404 0.71061668493287 GO:0097602 cullin family protein binding 5/2813 26/18639 0.192307692307692 1.27423500779349 0.354559176828404 0.71061668493287 GO:0015932 nucleobase-containing compound transmembrane transporter activity 10/2813 57/18639 0.175438596491228 1.16246000710985 0.355519908216178 0.71061668493287 GO:0008191 metalloendopeptidase inhibitor activity 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:0008195 phosphatidate phosphatase activity 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:0008474 palmitoyl-(protein) hydrolase activity 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:0034236 protein kinase A catalytic subunit binding 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:0052816 long-chain fatty acyl-CoA hydrolase activity 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:0061665 SUMO ligase activity 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:0070742 C2H2 zinc finger domain binding 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:0098599 palmitoyl hydrolase activity 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:0098847 sequence-specific single stranded DNA binding 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:1901474 azole transmembrane transporter activity 3/2813 14/18639 0.214285714285714 1.41986186582703 0.355868376435108 0.71061668493287 GO:0010851 cyclase regulator activity 4/2813 20/18639 0.2 1.32520440810523 0.356728439758467 0.71061668493287 GO:0031418 L-ascorbic acid binding 4/2813 20/18639 0.2 1.32520440810523 0.356728439758467 0.71061668493287 GO:0052745 inositol phosphate phosphatase activity 4/2813 20/18639 0.2 1.32520440810523 0.356728439758467 0.71061668493287 GO:0016830 carbon-carbon lyase activity 9/2813 51/18639 0.176470588235294 1.16929800715167 0.361228775908122 0.718437517744134 GO:0003774 cytoskeletal motor activity 25/2813 153/18639 0.163398692810458 1.08268333995525 0.365908672614533 0.72659007847743 GO:0051539 4 iron, 4 sulfur cluster binding 8/2813 45/18639 0.177777777777778 1.17795947387131 0.36718386811438 0.727966749621379 GO:0016776 phosphotransferase activity, phosphate group as acceptor 7/2813 39/18639 0.179487179487179 1.18928600727392 0.373399462893691 0.739118240632924 GO:0051540 metal cluster binding 13/2813 77/18639 0.168831168831169 1.11867904580311 0.376688831344383 0.744451387064491 GO:0019956 chemokine binding 6/2813 33/18639 0.181818181818182 1.20473128009566 0.37987813977818 0.74957027265379 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity 5/2813 27/18639 0.185185185185185 1.22704111861595 0.386587973511588 0.761608747815743 GO:0015174 basic amino acid transmembrane transporter activity 4/2813 21/18639 0.19047619047619 1.26209943629069 0.393393593194858 0.77379777529366 GO:0001786 phosphatidylserine binding 10/2813 59/18639 0.169491525423729 1.12305458314002 0.398555395044003 0.777849837378554 GO:0070888 E-box binding 10/2813 59/18639 0.169491525423729 1.12305458314002 0.398555395044003 0.777849837378554 GO:0005402 carbohydrate:monoatomic cation symporter activity 3/2813 15/18639 0.2 1.32520440810523 0.399806111458361 0.777849837378554 GO:0015556 C4-dicarboxylate transmembrane transporter activity 3/2813 15/18639 0.2 1.32520440810523 0.399806111458361 0.777849837378554 GO:0031386 protein tag activity 3/2813 15/18639 0.2 1.32520440810523 0.399806111458361 0.777849837378554 GO:0055105 ubiquitin-protein transferase inhibitor activity 3/2813 15/18639 0.2 1.32520440810523 0.399806111458361 0.777849837378554 GO:0141047 molecular tag activity 3/2813 15/18639 0.2 1.32520440810523 0.399806111458361 0.777849837378554 GO:0042379 chemokine receptor binding 12/2813 72/18639 0.166666666666667 1.10433700675435 0.403069372137892 0.782981031901402 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 21/2813 130/18639 0.161538461538462 1.07035740654653 0.40390677209163 0.783391274242836 GO:0016831 carboxy-lyase activity 6/2813 34/18639 0.176470588235294 1.16929800715167 0.408638134106106 0.791341030598667 GO:0004518 nuclease activity 33/2813 209/18639 0.157894736842105 1.04621400639886 0.417856547037948 0.806720391924152 GO:0051393 alpha-actinin binding 5/2813 28/18639 0.178571428571429 1.18321822152252 0.418514415954256 0.806720391924152 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding 5/2813 28/18639 0.178571428571429 1.18321822152252 0.418514415954256 0.806720391924152 GO:0005200 structural constituent of cytoskeleton 18/2813 112/18639 0.160714285714286 1.06489639937027 0.42555345300243 0.819026722624676 GO:0008173 RNA methyltransferase activity 11/2813 67/18639 0.164179104477612 1.0878543648625 0.43182987941397 0.829829768274772 GO:0000149 SNARE binding 17/2813 106/18639 0.160377358490566 1.06266391215985 0.433503018600371 0.830493531805611 GO:0008013 beta-catenin binding 17/2813 106/18639 0.160377358490566 1.06266391215985 0.433503018600371 0.830493531805611 GO:0004623 phospholipase A2 activity 6/2813 35/18639 0.171428571428571 1.13588949266162 0.437269505490046 0.835151376134424 GO:0034061 DNA polymerase activity 6/2813 35/18639 0.171428571428571 1.13588949266162 0.437269505490046 0.835151376134424 GO:0019905 syntaxin binding 10/2813 61/18639 0.163934426229508 1.08623312139773 0.441764104773564 0.837250722153406 GO:0000062 fatty-acyl-CoA binding 3/2813 16/18639 0.1875 1.24237913259865 0.442854246721652 0.837250722153406 GO:0003688 DNA replication origin binding 3/2813 16/18639 0.1875 1.24237913259865 0.442854246721652 0.837250722153406 GO:0043023 ribosomal large subunit binding 3/2813 16/18639 0.1875 1.24237913259865 0.442854246721652 0.837250722153406 GO:0004629 phospholipase C activity 5/2813 29/18639 0.172413793103448 1.14241759319416 0.450142082293611 0.837250722153406 GO:0016417 S-acyltransferase activity 5/2813 29/18639 0.172413793103448 1.14241759319416 0.450142082293611 0.837250722153406 GO:0043236 laminin binding 5/2813 29/18639 0.172413793103448 1.14241759319416 0.450142082293611 0.837250722153406 GO:0008374 O-acyltransferase activity 9/2813 55/18639 0.163636363636364 1.08425815208609 0.45262519620863 0.837250722153406 GO:0004090 carbonyl reductase (NADPH) activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0004382 GDP phosphatase activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0004955 prostaglandin receptor activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0008519 ammonium channel activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0008641 ubiquitin-like modifier activating enzyme activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0015187 glycine transmembrane transporter activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0015279 store-operated calcium channel activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0015643 toxic substance binding 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0016427 tRNA (cytidine) methyltransferase activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0031419 cobalamin binding 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0034596 phosphatidylinositol phosphate 4-phosphatase activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0035256 G protein-coupled glutamate receptor binding 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0047429 nucleoside triphosphate diphosphatase activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0070097 delta-catenin binding 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0098505 G-rich strand telomeric DNA binding 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0140940 histone H2A methyltransferase activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:1990259 histone H2AQ104 methyltransferase activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:1990757 ubiquitin ligase activator activity 2/2813 10/18639 0.2 1.32520440810523 0.459115903594913 0.837250722153406 GO:0008171 O-methyltransferase activity 4/2813 23/18639 0.173913043478261 1.15235165922194 0.465427244039358 0.845437849004359 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity 4/2813 23/18639 0.173913043478261 1.15235165922194 0.465427244039358 0.845437849004359 GO:0045505 dynein intermediate chain binding 6/2813 36/18639 0.166666666666667 1.10433700675435 0.465632836102321 0.845437849004359 GO:0017022 myosin binding 12/2813 76/18639 0.157894736842105 1.04621400639886 0.481209648596095 0.866100744241495 GO:0051536 iron-sulfur cluster binding 12/2813 76/18639 0.157894736842105 1.04621400639886 0.481209648596095 0.866100744241495 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 3/2813 17/18639 0.176470588235294 1.16929800715167 0.484628713804194 0.866100744241495 GO:0008484 sulfuric ester hydrolase activity 3/2813 17/18639 0.176470588235294 1.16929800715167 0.484628713804194 0.866100744241495 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 3/2813 17/18639 0.176470588235294 1.16929800715167 0.484628713804194 0.866100744241495 GO:0016018 cyclosporin A binding 3/2813 17/18639 0.176470588235294 1.16929800715167 0.484628713804194 0.866100744241495 GO:0019198 transmembrane receptor protein phosphatase activity 3/2813 17/18639 0.176470588235294 1.16929800715167 0.484628713804194 0.866100744241495 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 3/2813 17/18639 0.176470588235294 1.16929800715167 0.484628713804194 0.866100744241495 GO:0031489 myosin V binding 3/2813 17/18639 0.176470588235294 1.16929800715167 0.484628713804194 0.866100744241495 GO:0036041 long-chain fatty acid binding 3/2813 17/18639 0.176470588235294 1.16929800715167 0.484628713804194 0.866100744241495 GO:1901567 fatty acid derivative binding 3/2813 17/18639 0.176470588235294 1.16929800715167 0.484628713804194 0.866100744241495 GO:0015294 solute:monoatomic cation symporter activity 18/2813 116/18639 0.155172413793103 1.02817583387474 0.488679623760656 0.872094449821085 GO:0019838 growth factor binding 21/2813 136/18639 0.154411764705882 1.02313575625771 0.49133820135015 0.875589871636806 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 4/2813 24/18639 0.166666666666667 1.10433700675435 0.500298605341688 0.877097587757899 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity 4/2813 24/18639 0.166666666666667 1.10433700675435 0.500298605341688 0.877097587757899 GO:0015295 solute:proton symporter activity 4/2813 24/18639 0.166666666666667 1.10433700675435 0.500298605341688 0.877097587757899 GO:0070840 dynein complex binding 4/2813 24/18639 0.166666666666667 1.10433700675435 0.500298605341688 0.877097587757899 GO:0016248 channel inhibitor activity 7/2813 44/18639 0.159090909090909 1.0541398700837 0.503717922258462 0.877097587757899 GO:0019205 nucleobase-containing compound kinase activity 7/2813 44/18639 0.159090909090909 1.0541398700837 0.503717922258462 0.877097587757899 GO:0051117 ATPase binding 13/2813 84/18639 0.154761904761905 1.02545579198619 0.507393902286136 0.877097587757899 GO:0019955 cytokine binding 22/2813 144/18639 0.152777777777778 1.01230892285816 0.51092957140174 0.877097587757899 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0002162 dystroglycan binding 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0004954 prostanoid receptor activity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0005225 volume-sensitive anion channel activity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0005536 D-glucose binding 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0019206 nucleoside kinase activity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0032050 clathrin heavy chain binding 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0032794 GTPase activating protein binding 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0034056 estrogen response element binding 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0034594 phosphatidylinositol trisphosphate phosphatase activity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0034713 type I transforming growth factor beta receptor binding 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0035252 UDP-xylosyltransferase activity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0042285 xylosyltransferase activity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0047676 arachidonate-CoA ligase activity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0050786 RAGE receptor binding 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0070697 activin receptor binding 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0097493 structural molecule activity conferring elasticity 2/2813 11/18639 0.181818181818182 1.20473128009566 0.511376033407939 0.877097587757899 GO:0072349 modified amino acid transmembrane transporter activity 5/2813 31/18639 0.161290322580645 1.06871323234292 0.511815538819557 0.877097587757899 GO:1902936 phosphatidylinositol bisphosphate binding 17/2813 111/18639 0.153153153153153 1.01479616836887 0.514457994541177 0.880419905842698 GO:0000400 four-way junction DNA binding 3/2813 18/18639 0.166666666666667 1.10433700675435 0.524828992505571 0.893280366836013 GO:0015172 acidic amino acid transmembrane transporter activity 3/2813 18/18639 0.166666666666667 1.10433700675435 0.524828992505571 0.893280366836013 GO:0098641 cadherin binding involved in cell-cell adhesion 3/2813 18/18639 0.166666666666667 1.10433700675435 0.524828992505571 0.893280366836013 GO:1901611 phosphatidylglycerol binding 3/2813 18/18639 0.166666666666667 1.10433700675435 0.524828992505571 0.893280366836013 GO:0141110 transporter inhibitor activity 7/2813 45/18639 0.155555555555556 1.0307145396374 0.528868932232372 0.898933470411273 GO:0005518 collagen binding 11/2813 72/18639 0.152777777777778 1.01230892285816 0.532865833016857 0.902260340978473 GO:0019706 protein-cysteine S-palmitoyltransferase activity 4/2813 25/18639 0.16 1.06016352648418 0.534137781842644 0.902260340978473 GO:0019707 protein-cysteine S-acyltransferase activity 4/2813 25/18639 0.16 1.06016352648418 0.534137781842644 0.902260340978473 GO:0047617 fatty acyl-CoA hydrolase activity 4/2813 25/18639 0.16 1.06016352648418 0.534137781842644 0.902260340978473 GO:0140101 catalytic activity, acting on a tRNA 21/2813 139/18639 0.151079136690647 1.00105368957589 0.534432384224659 0.902260340978473 GO:0022884 macromolecule transmembrane transporter activity 5/2813 32/18639 0.15625 1.03531594383221 0.541570239461238 0.91184975715479 GO:0043425 bHLH transcription factor binding 5/2813 32/18639 0.15625 1.03531594383221 0.541570239461238 0.91184975715479 GO:0050660 flavin adenine dinucleotide binding 13/2813 86/18639 0.151162790697674 1.00160798287023 0.543753746201008 0.912551267776091 GO:0008235 metalloexopeptidase activity 10/2813 66/18639 0.151515151515152 1.00394273341305 0.547322663680372 0.912551267776091 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 6/2813 39/18639 0.153846153846154 1.01938800623479 0.54790642711389 0.912551267776091 GO:0048306 calcium-dependent protein binding 12/2813 80/18639 0.15 0.993903306078919 0.557154966138368 0.912551267776091 GO:0004864 protein phosphatase inhibitor activity 8/2813 53/18639 0.150943396226415 1.0001542702681 0.558581642543462 0.912551267776091 GO:0000340 RNA 7-methylguanosine cap binding 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0005165 neurotrophin receptor binding 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0005436 sodium:phosphate symporter activity 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0010853 cyclase activator activity 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0016840 carbon-nitrogen lyase activity 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0031543 peptidyl-proline dioxygenase activity 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0035497 cAMP response element binding 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0036009 protein-glutamine N-methyltransferase activity 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0042301 phosphate ion binding 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0043047 single-stranded telomeric DNA binding 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0070008 serine-type exopeptidase activity 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0097371 MDM2/MDM4 family protein binding 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0097677 STAT family protein binding 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:1990459 transferrin receptor binding 2/2813 12/18639 0.166666666666667 1.10433700675435 0.560187409861552 0.912551267776091 GO:0008081 phosphoric diester hydrolase activity 13/2813 87/18639 0.149425287356322 0.990095247434939 0.561590897558415 0.912551267776091 GO:0034987 immunoglobulin receptor binding 3/2813 19/18639 0.157894736842105 1.04621400639886 0.563229584974606 0.912551267776091 GO:0046527 glucosyltransferase activity 3/2813 19/18639 0.157894736842105 1.04621400639886 0.563229584974606 0.912551267776091 GO:0050145 nucleoside monophosphate kinase activity 3/2813 19/18639 0.157894736842105 1.04621400639886 0.563229584974606 0.912551267776091 GO:0097001 ceramide binding 3/2813 19/18639 0.157894736842105 1.04621400639886 0.563229584974606 0.912551267776091 GO:0120227 acyl-CoA binding 3/2813 19/18639 0.157894736842105 1.04621400639886 0.563229584974606 0.912551267776091 GO:0004112 cyclic-nucleotide phosphodiesterase activity 4/2813 26/18639 0.153846153846154 1.01938800623479 0.566788437299778 0.912551267776091 GO:0004435 phosphatidylinositol phospholipase C activity 4/2813 26/18639 0.153846153846154 1.01938800623479 0.566788437299778 0.912551267776091 GO:0008138 protein tyrosine/serine/threonine phosphatase activity 4/2813 26/18639 0.153846153846154 1.01938800623479 0.566788437299778 0.912551267776091 GO:0008157 protein phosphatase 1 binding 4/2813 26/18639 0.153846153846154 1.01938800623479 0.566788437299778 0.912551267776091 GO:0016289 acyl-CoA hydrolase activity 4/2813 26/18639 0.153846153846154 1.01938800623479 0.566788437299778 0.912551267776091 GO:0030507 spectrin binding 4/2813 26/18639 0.153846153846154 1.01938800623479 0.566788437299778 0.912551267776091 GO:0050840 extracellular matrix binding 10/2813 67/18639 0.149253731343284 0.988958513511362 0.567584555656933 0.912658456461213 GO:0015026 coreceptor activity 9/2813 61/18639 0.147540983606557 0.977609809257953 0.584271339841979 0.93828426975907 GO:0004620 phospholipase activity 16/2813 109/18639 0.146788990825688 0.972627088517597 0.589201842601963 0.944989109096226 GO:0005385 zinc ion transmembrane transporter activity 4/2813 27/18639 0.148148148148148 0.98163289489276 0.598127648393377 0.949067565167722 GO:0051427 hormone receptor binding 5/2813 34/18639 0.147058823529412 0.974415005959725 0.598341362239365 0.949067565167722 GO:0090482 vitamin transmembrane transporter activity 5/2813 34/18639 0.147058823529412 0.974415005959725 0.598341362239365 0.949067565167722 GO:0004812 aminoacyl-tRNA ligase activity 6/2813 41/18639 0.146341463414634 0.969661762028214 0.599427585820093 0.949067565167722 GO:0016875 ligase activity, forming carbon-oxygen bonds 6/2813 41/18639 0.146341463414634 0.969661762028214 0.599427585820093 0.949067565167722 GO:0016877 ligase activity, forming carbon-sulfur bonds 6/2813 41/18639 0.146341463414634 0.969661762028214 0.599427585820093 0.949067565167722 GO:0000339 RNA cap binding 3/2813 20/18639 0.15 0.993903306078919 0.599670963542161 0.949067565167722 GO:0016408 C-acyltransferase activity 3/2813 20/18639 0.15 0.993903306078919 0.599670963542161 0.949067565167722 GO:0016505 peptidase activator activity involved in apoptotic process 3/2813 20/18639 0.15 0.993903306078919 0.599670963542161 0.949067565167722 GO:0030742 GTP-dependent protein binding 3/2813 20/18639 0.15 0.993903306078919 0.599670963542161 0.949067565167722 GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity 2/2813 13/18639 0.153846153846154 1.01938800623479 0.605400413272456 0.949067565167722 GO:0005338 nucleotide-sugar transmembrane transporter activity 2/2813 13/18639 0.153846153846154 1.01938800623479 0.605400413272456 0.949067565167722 GO:0008035 high-density lipoprotein particle binding 2/2813 13/18639 0.153846153846154 1.01938800623479 0.605400413272456 0.949067565167722 GO:0017154 semaphorin receptor activity 2/2813 13/18639 0.153846153846154 1.01938800623479 0.605400413272456 0.949067565167722 GO:0035673 oligopeptide transmembrane transporter activity 2/2813 13/18639 0.153846153846154 1.01938800623479 0.605400413272456 0.949067565167722 GO:0045028 G protein-coupled purinergic nucleotide receptor activity 2/2813 13/18639 0.153846153846154 1.01938800623479 0.605400413272456 0.949067565167722 GO:0051011 microtubule minus-end binding 2/2813 13/18639 0.153846153846154 1.01938800623479 0.605400413272456 0.949067565167722 GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity 2/2813 13/18639 0.153846153846154 1.01938800623479 0.605400413272456 0.949067565167722 GO:0008307 structural constituent of muscle 6/2813 42/18639 0.142857142857143 0.946574577218018 0.623963430962734 0.976943995161928 GO:0005343 organic acid:sodium symporter activity 5/2813 35/18639 0.142857142857143 0.946574577218018 0.625186671697585 0.977635657867098 GO:0050698 proteoglycan sulfotransferase activity 4/2813 28/18639 0.142857142857143 0.946574577218018 0.62806318713323 0.979684597386123 GO:0051537 2 iron, 2 sulfur cluster binding 4/2813 28/18639 0.142857142857143 0.946574577218018 0.62806318713323 0.979684597386123 GO:0015293 symporter activity 21/2813 146/18639 0.143835616438356 0.95305796473321 0.630195693769802 0.981786815574124 GO:0019200 carbohydrate kinase activity 3/2813 21/18639 0.142857142857143 0.946574577218018 0.634050525266711 0.986563690433651 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 26/2813 181/18639 0.143646408839779 0.951804271014803 0.639910126631221 0.991629683315009 GO:0046943 carboxylic acid transmembrane transporter activity 27/2813 188/18639 0.143617021276596 0.951609548373433 0.641778136094717 0.991629683315009 GO:0070279 vitamin B6 binding 8/2813 57/18639 0.140350877192982 0.929968005687878 0.644702985012371 0.991629683315009 GO:0052689 carboxylic ester hydrolase activity 13/2813 92/18639 0.141304347826087 0.936285723117822 0.64622717691918 0.991629683315009 GO:0004065 arylsulfatase activity 2/2813 14/18639 0.142857142857143 0.946574577218018 0.646989086078681 0.991629683315009 GO:0005347 ATP transmembrane transporter activity 2/2813 14/18639 0.142857142857143 0.946574577218018 0.646989086078681 0.991629683315009 GO:0005545 1-phosphatidylinositol binding 2/2813 14/18639 0.142857142857143 0.946574577218018 0.646989086078681 0.991629683315009 GO:0008494 translation activator activity 2/2813 14/18639 0.142857142857143 0.946574577218018 0.646989086078681 0.991629683315009 GO:0008559 ABC-type xenobiotic transporter activity 2/2813 14/18639 0.142857142857143 0.946574577218018 0.646989086078681 0.991629683315009 GO:0015386 potassium:proton antiporter activity 2/2813 14/18639 0.142857142857143 0.946574577218018 0.646989086078681 0.991629683315009 GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity 2/2813 14/18639 0.142857142857143 0.946574577218018 0.646989086078681 0.991629683315009 GO:0008200 ion channel inhibitor activity 6/2813 43/18639 0.13953488372093 0.924561214957134 0.647611072156964 0.991629683315009 GO:0008375 acetylglucosaminyltransferase activity 6/2813 43/18639 0.13953488372093 0.924561214957134 0.647611072156964 0.991629683315009 GO:0004033 aldo-keto reductase (NADPH) activity 5/2813 36/18639 0.138888888888889 0.920280838961962 0.650921161309724 0.994264191451117 GO:0004869 cysteine-type endopeptidase inhibitor activity 5/2813 36/18639 0.138888888888889 0.920280838961962 0.650921161309724 0.994264191451117 GO:0005342 organic acid transmembrane transporter activity 27/2813 189/18639 0.142857142857143 0.946574577218018 0.65307604984947 0.996339193124008 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 12/2813 86/18639 0.13953488372093 0.924561214957134 0.661901789447694 0.999999999999931 GO:0015370 solute:sodium symporter activity 11/2813 79/18639 0.139240506329114 0.922610663870727 0.661977087934102 0.999999999999931 GO:0016835 carbon-oxygen lyase activity 11/2813 79/18639 0.139240506329114 0.922610663870727 0.661977087934102 0.999999999999931 GO:0160215 deacylase activity 9/2813 65/18639 0.138461538461538 0.91744920561131 0.663231078184537 0.999999999999931 GO:0008093 cytoskeletal anchor activity 3/2813 22/18639 0.136363636363636 0.903548460071745 0.666313910294713 0.999999999999931 GO:0015377 chloride:monoatomic cation symporter activity 3/2813 22/18639 0.136363636363636 0.903548460071745 0.666313910294713 0.999999999999931 GO:0031683 G-protein beta/gamma-subunit complex binding 3/2813 22/18639 0.136363636363636 0.903548460071745 0.666313910294713 0.999999999999931 GO:0016597 amino acid binding 7/2813 51/18639 0.137254901960784 0.90945400556241 0.666914652751594 0.999999999999931 GO:0016790 thiolester hydrolase activity 6/2813 44/18639 0.136363636363636 0.903548460071745 0.67033104319357 0.999999999999931 GO:0019213 deacetylase activity 5/2813 37/18639 0.135135135135135 0.895408383854882 0.675502454453395 0.999999999999931 GO:0030551 cyclic nucleotide binding 5/2813 37/18639 0.135135135135135 0.895408383854882 0.675502454453395 0.999999999999931 GO:0008106 alcohol dehydrogenase (NADP+) activity 4/2813 30/18639 0.133333333333333 0.883469605403484 0.683489968677396 0.999999999999931 GO:0016769 transferase activity, transferring nitrogenous groups 4/2813 30/18639 0.133333333333333 0.883469605403484 0.683489968677396 0.999999999999931 GO:0004089 carbonate dehydratase activity 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0004467 long-chain fatty acid-CoA ligase activity 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0005041 low-density lipoprotein particle receptor activity 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0015929 hexosaminidase activity 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0016846 carbon-sulfur lyase activity 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0033130 acetylcholine receptor binding 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0048531 beta-1,3-galactosyltransferase activity 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0050700 CARD domain binding 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0140161 monocarboxylate:sodium symporter activity 2/2813 15/18639 0.133333333333333 0.883469605403484 0.685017236020268 0.999999999999931 GO:0016298 lipase activity 18/2813 130/18639 0.138461538461538 0.91744920561131 0.691454364521956 0.999999999999931 GO:0008238 exopeptidase activity 14/2813 102/18639 0.137254901960784 0.90945400556241 0.691932596894832 0.999999999999931 GO:0015171 amino acid transmembrane transporter activity 14/2813 102/18639 0.137254901960784 0.90945400556241 0.691932596894832 0.999999999999931 GO:0046915 transition metal ion transmembrane transporter activity 6/2813 45/18639 0.133333333333333 0.883469605403484 0.692094444879908 0.999999999999931 GO:0000295 adenine nucleotide transmembrane transporter activity 3/2813 23/18639 0.130434782608696 0.864263744416451 0.696446910233016 0.999999999999931 GO:0005212 structural constituent of eye lens 3/2813 23/18639 0.130434782608696 0.864263744416451 0.696446910233016 0.999999999999931 GO:0005283 amino acid:sodium symporter activity 3/2813 23/18639 0.130434782608696 0.864263744416451 0.696446910233016 0.999999999999931 GO:0016829 lyase activity 28/2813 200/18639 0.14 0.927643085673658 0.697246464523283 0.999999999999931 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 9/2813 67/18639 0.134328358208955 0.890062662160226 0.699213969897384 0.999999999999931 GO:0005544 calcium-dependent phospholipid binding 7/2813 53/18639 0.132075471698113 0.875134986484583 0.706919206456842 0.999999999999931 GO:1901505 carbohydrate derivative transmembrane transporter activity 7/2813 53/18639 0.132075471698113 0.875134986484583 0.706919206456842 0.999999999999931 GO:0005452 solute:inorganic anion antiporter activity 4/2813 31/18639 0.129032258064516 0.854970585874339 0.708923217545224 0.999999999999931 GO:0016878 acid-thiol ligase activity 4/2813 31/18639 0.129032258064516 0.854970585874339 0.708923217545224 0.999999999999931 GO:0070273 phosphatidylinositol-4-phosphate binding 4/2813 31/18639 0.129032258064516 0.854970585874339 0.708923217545224 0.999999999999931 GO:0003777 microtubule motor activity 9/2813 68/18639 0.132352941176471 0.876973505363752 0.716261496731739 0.999999999999931 GO:0004198 calcium-dependent cysteine-type endopeptidase activity 2/2813 16/18639 0.125 0.828252755065766 0.719611948777213 0.999999999999931 GO:0005149 interleukin-1 receptor binding 2/2813 16/18639 0.125 0.828252755065766 0.719611948777213 0.999999999999931 GO:0008296 3'-5'-DNA exonuclease activity 2/2813 16/18639 0.125 0.828252755065766 0.719611948777213 0.999999999999931 GO:0015378 sodium:chloride symporter activity 2/2813 16/18639 0.125 0.828252755065766 0.719611948777213 0.999999999999931 GO:0015385 sodium:proton antiporter activity 2/2813 16/18639 0.125 0.828252755065766 0.719611948777213 0.999999999999931 GO:0015562 efflux transmembrane transporter activity 2/2813 16/18639 0.125 0.828252755065766 0.719611948777213 0.999999999999931 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity 2/2813 16/18639 0.125 0.828252755065766 0.719611948777213 0.999999999999931 GO:0031435 mitogen-activated protein kinase kinase kinase binding 2/2813 16/18639 0.125 0.828252755065766 0.719611948777213 0.999999999999931 GO:0106018 phosphatidylinositol-3,5-bisphosphate phosphatase activity 2/2813 16/18639 0.125 0.828252755065766 0.719611948777213 0.999999999999931 GO:0004622 lysophospholipase activity 3/2813 24/18639 0.125 0.828252755065766 0.724468096646063 0.999999999999931 GO:0004806 triacylglycerol lipase activity 3/2813 24/18639 0.125 0.828252755065766 0.724468096646063 0.999999999999931 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 3/2813 24/18639 0.125 0.828252755065766 0.724468096646063 0.999999999999931 GO:0019957 C-C chemokine binding 3/2813 24/18639 0.125 0.828252755065766 0.724468096646063 0.999999999999931 GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 7/2813 54/18639 0.12962962962963 0.858928783031165 0.725676595694992 0.999999999999931 GO:0050661 NADP binding 7/2813 54/18639 0.12962962962963 0.858928783031165 0.725676595694992 0.999999999999931 GO:0016247 channel regulator activity 23/2813 168/18639 0.136904761904762 0.907133969833934 0.726535519369625 0.999999999999931 GO:0005504 fatty acid binding 6/2813 47/18639 0.127659574468085 0.845875154109718 0.732683837332931 0.999999999999931 GO:0140359 ABC-type transporter activity 6/2813 47/18639 0.127659574468085 0.845875154109718 0.732683837332931 0.999999999999931 GO:0015106 bicarbonate transmembrane transporter activity 4/2813 32/18639 0.125 0.828252755065766 0.732830785842937 0.999999999999931 GO:0042626 ATPase-coupled transmembrane transporter activity 13/2813 98/18639 0.13265306122449 0.878962107416731 0.735132645039814 0.999999999999931 GO:0004175 endopeptidase activity 57/2813 405/18639 0.140740740740741 0.932551250148122 0.738785381529273 0.999999999999931 GO:0004519 endonuclease activity 17/2813 127/18639 0.133858267716535 0.886947832196411 0.741157367049243 0.999999999999931 GO:0141108 transporter regulator activity 23/2813 170/18639 0.135294117647059 0.896461805482947 0.747253307675028 0.999999999999931 GO:0008483 transaminase activity 3/2813 25/18639 0.12 0.795122644863135 0.750422230482893 0.999999999999931 GO:0015296 monoatomic anion:monoatomic cation symporter activity 3/2813 25/18639 0.12 0.795122644863135 0.750422230482893 0.999999999999931 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3/2813 25/18639 0.12 0.795122644863135 0.750422230482893 0.999999999999931 GO:0016895 DNA exonuclease activity, producing 5'-phosphomonoesters 3/2813 25/18639 0.12 0.795122644863135 0.750422230482893 0.999999999999931 GO:0004659 prenyltransferase activity 2/2813 17/18639 0.117647058823529 0.77953200476778 0.750943046773616 0.999999999999931 GO:0008569 minus-end-directed microtubule motor activity 2/2813 17/18639 0.117647058823529 0.77953200476778 0.750943046773616 0.999999999999931 GO:0015278 intracellularly gated calcium channel activity 2/2813 17/18639 0.117647058823529 0.77953200476778 0.750943046773616 0.999999999999931 GO:0017110 nucleoside diphosphate phosphatase activity 2/2813 17/18639 0.117647058823529 0.77953200476778 0.750943046773616 0.999999999999931 GO:0032977 membrane insertase activity 2/2813 17/18639 0.117647058823529 0.77953200476778 0.750943046773616 0.999999999999931 GO:0045125 bioactive lipid receptor activity 2/2813 17/18639 0.117647058823529 0.77953200476778 0.750943046773616 0.999999999999931 GO:0045236 CXCR chemokine receptor binding 2/2813 17/18639 0.117647058823529 0.77953200476778 0.750943046773616 0.999999999999931 GO:0048038 quinone binding 2/2813 17/18639 0.117647058823529 0.77953200476778 0.750943046773616 0.999999999999931 GO:0008514 organic anion transmembrane transporter activity 37/2813 269/18639 0.137546468401487 0.911385931224784 0.755866749071425 0.999999999999931 GO:0030170 pyridoxal phosphate binding 7/2813 56/18639 0.125 0.828252755065766 0.760666073576339 0.999999999999931 GO:0140318 protein transporter activity 5/2813 41/18639 0.121951219512195 0.808051468356845 0.761933870707145 0.999999999999931 GO:0004536 DNA nuclease activity 8/2813 64/18639 0.125 0.828252755065766 0.769502549562588 0.999999999999931 GO:0004529 DNA exonuclease activity 3/2813 26/18639 0.115384615384615 0.764541004676092 0.774374464376343 0.999999999999931 GO:0008198 ferrous iron binding 3/2813 26/18639 0.115384615384615 0.764541004676092 0.774374464376343 0.999999999999931 GO:0015145 monosaccharide transmembrane transporter activity 3/2813 26/18639 0.115384615384615 0.764541004676092 0.774374464376343 0.999999999999931 GO:0015216 purine nucleotide transmembrane transporter activity 3/2813 26/18639 0.115384615384615 0.764541004676092 0.774374464376343 0.999999999999931 GO:0030247 polysaccharide binding 3/2813 26/18639 0.115384615384615 0.764541004676092 0.774374464376343 0.999999999999931 GO:0051139 metal cation:proton antiporter activity 3/2813 26/18639 0.115384615384615 0.764541004676092 0.774374464376343 0.999999999999931 GO:0008175 tRNA methyltransferase activity 4/2813 34/18639 0.117647058823529 0.77953200476778 0.77614733677485 0.999999999999931 GO:0003746 translation elongation factor activity 2/2813 18/18639 0.111111111111111 0.73622467116957 0.779207303557122 0.999999999999931 GO:0015373 monoatomic anion:sodium symporter activity 2/2813 18/18639 0.111111111111111 0.73622467116957 0.779207303557122 0.999999999999931 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 2/2813 18/18639 0.111111111111111 0.73622467116957 0.779207303557122 0.999999999999931 GO:0017075 syntaxin-1 binding 2/2813 18/18639 0.111111111111111 0.73622467116957 0.779207303557122 0.999999999999931 GO:0030228 lipoprotein particle receptor activity 2/2813 18/18639 0.111111111111111 0.73622467116957 0.779207303557122 0.999999999999931 GO:0099602 neurotransmitter receptor regulator activity 2/2813 18/18639 0.111111111111111 0.73622467116957 0.779207303557122 0.999999999999931 GO:1990381 ubiquitin-specific protease binding 2/2813 18/18639 0.111111111111111 0.73622467116957 0.779207303557122 0.999999999999931 GO:0004520 DNA endonuclease activity 5/2813 42/18639 0.119047619047619 0.788812147681682 0.78057852472666 0.999999999999931 GO:0030246 carbohydrate binding 38/2813 280/18639 0.135714285714286 0.899245848357117 0.786256490394571 0.999999999999931 GO:0099106 ion channel regulator activity 21/2813 160/18639 0.13125 0.869665392819054 0.788213662974337 0.999999999999931 GO:0004521 RNA endonuclease activity 9/2813 73/18639 0.123287671232877 0.81690682691418 0.791764006893804 0.999999999999931 GO:0003735 structural constituent of ribosome 23/2813 175/18639 0.131428571428571 0.870848611040577 0.794565695842352 0.999999999999931 GO:0008320 protein transmembrane transporter activity 3/2813 27/18639 0.111111111111111 0.73622467116957 0.796405316374214 0.999999999999931 GO:0016405 CoA-ligase activity 3/2813 27/18639 0.111111111111111 0.73622467116957 0.796405316374214 0.999999999999931 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors 3/2813 27/18639 0.111111111111111 0.73622467116957 0.796405316374214 0.999999999999931 GO:0035255 ionotropic glutamate receptor binding 3/2813 27/18639 0.111111111111111 0.73622467116957 0.796405316374214 0.999999999999931 GO:0005178 integrin binding 21/2813 161/18639 0.130434782608696 0.864263744416451 0.797447540988739 0.999999999999931 GO:0016758 hexosyltransferase activity 26/2813 197/18639 0.131979695431472 0.87450037083086 0.799640435867597 0.999999999999931 GO:0005346 purine ribonucleotide transmembrane transporter activity 2/2813 19/18639 0.105263157894737 0.697476004265908 0.804616446919771 0.999999999999931 GO:0008574 plus-end-directed microtubule motor activity 2/2813 19/18639 0.105263157894737 0.697476004265908 0.804616446919771 0.999999999999931 GO:0022821 solute:potassium antiporter activity 2/2813 19/18639 0.105263157894737 0.697476004265908 0.804616446919771 0.999999999999931 GO:0043395 heparan sulfate proteoglycan binding 2/2813 19/18639 0.105263157894737 0.697476004265908 0.804616446919771 0.999999999999931 GO:0048029 monosaccharide binding 9/2813 74/18639 0.121621621621622 0.805867545469394 0.80492063944092 0.999999999999931 GO:0000182 rDNA binding 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0005337 nucleoside transmembrane transporter activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0008190 eukaryotic initiation factor 4E binding 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0008239 dipeptidyl-peptidase activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0015924 mannosyl-oligosaccharide mannosidase activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0016783 sulfurtransferase activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0016868 intramolecular phosphotransferase activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0031434 mitogen-activated protein kinase kinase binding 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0031956 medium-chain fatty acid-CoA ligase activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0032356 oxidized DNA binding 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0043121 neurotrophin binding 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0043225 ATPase-coupled inorganic anion transmembrane transporter activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0043422 protein kinase B binding 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0050308 sugar-phosphatase activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0141109 transporter activator activity 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:1990763 arrestin family protein binding 1/2813 10/18639 0.1 0.662602204052613 0.805329971264495 0.999999999999931 GO:0015459 potassium channel regulator activity 7/2813 59/18639 0.11864406779661 0.786138208198015 0.806893270186615 0.999999999999931 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 7/2813 59/18639 0.11864406779661 0.786138208198015 0.806893270186615 0.999999999999931 GO:0008237 metallopeptidase activity 24/2813 184/18639 0.130434782608696 0.864263744416451 0.810222057938395 0.999999999999931 GO:0016866 intramolecular transferase activity 3/2813 28/18639 0.107142857142857 0.709930932913514 0.816606371883131 0.999999999999931 GO:0046625 sphingolipid binding 3/2813 28/18639 0.107142857142857 0.709930932913514 0.816606371883131 0.999999999999931 GO:0051119 sugar transmembrane transporter activity 3/2813 28/18639 0.107142857142857 0.709930932913514 0.816606371883131 0.999999999999931 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity 6/2813 52/18639 0.115384615384615 0.764541004676092 0.817057387351452 0.999999999999931 GO:0015297 antiporter activity 17/2813 135/18639 0.125925925925926 0.834387960658846 0.824342297634048 0.999999999999931 GO:0001614 purinergic nucleotide receptor activity 2/2813 20/18639 0.1 0.662602204052613 0.827388167295061 0.999999999999931 GO:0001972 retinoic acid binding 2/2813 20/18639 0.1 0.662602204052613 0.827388167295061 0.999999999999931 GO:0015464 acetylcholine receptor activity 2/2813 20/18639 0.1 0.662602204052613 0.827388167295061 0.999999999999931 GO:0016502 nucleotide receptor activity 2/2813 20/18639 0.1 0.662602204052613 0.827388167295061 0.999999999999931 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors 2/2813 20/18639 0.1 0.662602204052613 0.827388167295061 0.999999999999931 GO:0043394 proteoglycan binding 4/2813 37/18639 0.108108108108108 0.716326707083906 0.83046719899434 0.999999999999931 GO:0070001 aspartic-type peptidase activity 4/2813 37/18639 0.108108108108108 0.716326707083906 0.83046719899434 0.999999999999931 GO:0016860 intramolecular oxidoreductase activity 6/2813 53/18639 0.113207547169811 0.750115702701071 0.831117580657147 0.999999999999931 GO:0017046 peptide hormone binding 6/2813 53/18639 0.113207547169811 0.750115702701071 0.831117580657147 0.999999999999931 GO:0015291 secondary active transmembrane transporter activity 38/2813 287/18639 0.132404181184669 0.877313022787432 0.832815694022951 0.999999999999931 GO:0000099 sulfur amino acid transmembrane transporter activity 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0001851 complement component C3b binding 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0004016 adenylate cyclase activity 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0005114 type II transforming growth factor beta receptor binding 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0008199 ferric iron binding 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0016725 oxidoreductase activity, acting on CH or CH2 groups 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0019203 carbohydrate phosphatase activity 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0019215 intermediate filament binding 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0032404 mismatch repair complex binding 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0048185 activin binding 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0050998 nitric-oxide synthase binding 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:1990948 ubiquitin ligase inhibitor activity 1/2813 11/18639 0.0909090909090909 0.60236564004783 0.83472536505015 0.999999999999931 GO:0003785 actin monomer binding 3/2813 29/18639 0.103448275862069 0.685450555916496 0.835076657418773 0.999999999999931 GO:0004181 metallocarboxypeptidase activity 3/2813 29/18639 0.103448275862069 0.685450555916496 0.835076657418773 0.999999999999931 GO:0005416 amino acid:monoatomic cation symporter activity 3/2813 29/18639 0.103448275862069 0.685450555916496 0.835076657418773 0.999999999999931 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding 3/2813 29/18639 0.103448275862069 0.685450555916496 0.835076657418773 0.999999999999931 GO:0016853 isomerase activity 23/2813 180/18639 0.127777777777778 0.846658371845005 0.835409684165622 0.999999999999931 GO:0004180 carboxypeptidase activity 5/2813 46/18639 0.108695652173913 0.72021978701371 0.843997934846731 0.999999999999931 GO:0003823 antigen binding 22/2813 174/18639 0.126436781609195 0.837772901675718 0.844796221094313 0.999999999999931 GO:0000146 microfilament motor activity 4/2813 38/18639 0.105263157894737 0.697476004265908 0.845945346255768 0.999999999999931 GO:0042887 amide transmembrane transporter activity 4/2813 38/18639 0.105263157894737 0.697476004265908 0.845945346255768 0.999999999999931 GO:1904047 S-adenosyl-L-methionine binding 2/2813 21/18639 0.0952380952380952 0.631049718145346 0.847739498034887 0.999999999999931 GO:0008028 monocarboxylic acid transmembrane transporter activity 8/2813 70/18639 0.114285714285714 0.757259661774415 0.848378469462171 0.999999999999931 GO:0016782 transferase activity, transferring sulphur-containing groups 8/2813 70/18639 0.114285714285714 0.757259661774415 0.848378469462171 0.999999999999931 GO:0033612 receptor serine/threonine kinase binding 3/2813 30/18639 0.1 0.662602204052613 0.851919622834482 0.999999999999931 GO:0098918 structural constituent of synapse 3/2813 30/18639 0.1 0.662602204052613 0.851919622834482 0.999999999999931 GO:0016209 antioxidant activity 10/2813 86/18639 0.116279069767442 0.770467679130945 0.854605350126902 0.999999999999931 GO:0005507 copper ion binding 7/2813 63/18639 0.111111111111111 0.73622467116957 0.85743878356327 0.999999999999931 GO:0042562 hormone binding 11/2813 94/18639 0.117021276595745 0.775385557933909 0.858061787717738 0.999999999999931 GO:0000995 RNA polymerase III general transcription initiation factor activity 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0003720 telomerase activity 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0004859 phospholipase inhibitor activity 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0005025 transforming growth factor beta receptor activity, type I 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0005026 transforming growth factor beta receptor activity, type II 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0005247 voltage-gated chloride channel activity 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0008179 adenylate cyclase binding 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0015132 prostaglandin transmembrane transporter activity 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0015166 polyol transmembrane transporter activity 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0016208 AMP binding 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0016361 activin receptor activity, type I 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0016362 activin receptor activity, type II 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0016423 tRNA (guanine) methyltransferase activity 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0016801 hydrolase activity, acting on ether bonds 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0016803 ether hydrolase activity 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0017002 activin receptor activity 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0045295 gamma-catenin binding 1/2813 12/18639 0.0833333333333333 0.552168503377177 0.859683360976386 0.999999999999931 GO:0008649 rRNA methyltransferase activity 2/2813 22/18639 0.0909090909090909 0.60236564004783 0.865882056808904 0.999999999999931 GO:0005310 dicarboxylic acid transmembrane transporter activity 3/2813 31/18639 0.0967741935483871 0.641227939405754 0.867240666258331 0.999999999999931 GO:0032266 phosphatidylinositol-3-phosphate binding 5/2813 48/18639 0.104166666666667 0.690210629221472 0.869546388711194 0.999999999999931 GO:0015144 carbohydrate transmembrane transporter activity 4/2813 40/18639 0.1 0.662602204052613 0.873334257893218 0.999999999999931 GO:0004601 peroxidase activity 6/2813 57/18639 0.105263157894737 0.697476004265908 0.878879019569303 0.999999999999931 GO:0002161 aminoacyl-tRNA editing activity 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0003964 RNA-directed DNA polymerase activity 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0004465 lipoprotein lipase activity 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0008253 5'-nucleotidase activity 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0009982 pseudouridine synthase activity 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0015651 quaternary ammonium group transmembrane transporter activity 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0019104 DNA N-glycosylase activity 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0031432 titin binding 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0045159 myosin II binding 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0070123 transforming growth factor beta receptor activity, type III 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0071714 icosanoid transmembrane transporter activity 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0071837 HMG box domain binding 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0089720 caspase binding 1/2813 13/18639 0.0769230769230769 0.509694003117395 0.88087360661838 0.999999999999931 GO:0004022 alcohol dehydrogenase (NAD+) activity 2/2813 23/18639 0.0869565217391304 0.576175829610968 0.882018737435179 0.999999999999931 GO:0004602 glutathione peroxidase activity 2/2813 23/18639 0.0869565217391304 0.576175829610968 0.882018737435179 0.999999999999931 GO:0016493 C-C chemokine receptor activity 2/2813 23/18639 0.0869565217391304 0.576175829610968 0.882018737435179 0.999999999999931 GO:0016849 phosphorus-oxygen lyase activity 2/2813 23/18639 0.0869565217391304 0.576175829610968 0.882018737435179 0.999999999999931 GO:0031681 G-protein beta-subunit binding 2/2813 23/18639 0.0869565217391304 0.576175829610968 0.882018737435179 0.999999999999931 GO:0099186 structural constituent of postsynapse 2/2813 23/18639 0.0869565217391304 0.576175829610968 0.882018737435179 0.999999999999931 GO:0140102 catalytic activity, acting on a rRNA 2/2813 23/18639 0.0869565217391304 0.576175829610968 0.882018737435179 0.999999999999931 GO:0001530 lipopolysaccharide binding 4/2813 41/18639 0.0975609756097561 0.646441174685476 0.885377542994415 0.999999999999931 GO:0008137 NADH dehydrogenase (ubiquinone) activity 4/2813 41/18639 0.0975609756097561 0.646441174685476 0.885377542994415 0.999999999999931 GO:0017080 sodium channel regulator activity 4/2813 41/18639 0.0975609756097561 0.646441174685476 0.885377542994415 0.999999999999931 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 3/2813 33/18639 0.0909090909090909 0.60236564004783 0.893736751627793 0.999999999999931 GO:0015149 hexose transmembrane transporter activity 2/2813 24/18639 0.0833333333333333 0.552168503377177 0.896341522961463 0.999999999999931 GO:0030215 semaphorin receptor binding 2/2813 24/18639 0.0833333333333333 0.552168503377177 0.896341522961463 0.999999999999931 GO:0055056 D-glucose transmembrane transporter activity 2/2813 24/18639 0.0833333333333333 0.552168503377177 0.896341522961463 0.999999999999931 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 2/2813 24/18639 0.0833333333333333 0.552168503377177 0.896341522961463 0.999999999999931 GO:0140612 DNA damage sensor activity 2/2813 24/18639 0.0833333333333333 0.552168503377177 0.896341522961463 0.999999999999931 GO:0019894 kinesin binding 4/2813 42/18639 0.0952380952380952 0.631049718145346 0.896409018601547 0.999999999999931 GO:0042056 chemoattractant activity 4/2813 42/18639 0.0952380952380952 0.631049718145346 0.896409018601547 0.999999999999931 GO:0072341 modified amino acid binding 10/2813 91/18639 0.10989010989011 0.728134290167706 0.897347040037444 0.999999999999931 GO:0005344 oxygen carrier activity 1/2813 14/18639 0.0714285714285714 0.473287288609009 0.898864723582973 0.999999999999931 GO:0016530 metallochaperone activity 1/2813 14/18639 0.0714285714285714 0.473287288609009 0.898864723582973 0.999999999999931 GO:0030283 testosterone dehydrogenase [NAD(P)+] activity 1/2813 14/18639 0.0714285714285714 0.473287288609009 0.898864723582973 0.999999999999931 GO:0031404 chloride ion binding 1/2813 14/18639 0.0714285714285714 0.473287288609009 0.898864723582973 0.999999999999931 GO:0032036 myosin heavy chain binding 1/2813 14/18639 0.0714285714285714 0.473287288609009 0.898864723582973 0.999999999999931 GO:0043176 amine binding 1/2813 14/18639 0.0714285714285714 0.473287288609009 0.898864723582973 0.999999999999931 GO:0098821 BMP receptor activity 1/2813 14/18639 0.0714285714285714 0.473287288609009 0.898864723582973 0.999999999999931 GO:1901612 cardiolipin binding 1/2813 14/18639 0.0714285714285714 0.473287288609009 0.898864723582973 0.999999999999931 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 3/2813 34/18639 0.0882352941176471 0.584649003575835 0.905116372420014 0.999999999999931 GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 3/2813 34/18639 0.0882352941176471 0.584649003575835 0.905116372420014 0.999999999999931 GO:0000030 mannosyltransferase activity 2/2813 25/18639 0.08 0.53008176324209 0.909030157090034 0.999999999999931 GO:0005537 D-mannose binding 2/2813 25/18639 0.08 0.53008176324209 0.909030157090034 0.999999999999931 GO:0015645 fatty acid ligase activity 2/2813 25/18639 0.08 0.53008176324209 0.909030157090034 0.999999999999931 GO:0120515 fatty acid-CoA ligase activity 2/2813 25/18639 0.08 0.53008176324209 0.909030157090034 0.999999999999931 GO:0015085 calcium ion transmembrane transporter activity 17/2813 147/18639 0.115646258503401 0.76627465774792 0.909635164375012 0.999999999999931 GO:0004559 alpha-mannosidase activity 1/2813 15/18639 0.0666666666666667 0.441734802701742 0.914139544123166 0.999999999999931 GO:0004865 protein serine/threonine phosphatase inhibitor activity 1/2813 15/18639 0.0666666666666667 0.441734802701742 0.914139544123166 0.999999999999931 GO:0005523 tropomyosin binding 1/2813 15/18639 0.0666666666666667 0.441734802701742 0.914139544123166 0.999999999999931 GO:0008252 nucleotidase activity 1/2813 15/18639 0.0666666666666667 0.441734802701742 0.914139544123166 0.999999999999931 GO:0031005 filamin binding 1/2813 15/18639 0.0666666666666667 0.441734802701742 0.914139544123166 0.999999999999931 GO:0034483 heparan sulfate sulfotransferase activity 1/2813 15/18639 0.0666666666666667 0.441734802701742 0.914139544123166 0.999999999999931 GO:0050780 dopamine receptor binding 1/2813 15/18639 0.0666666666666667 0.441734802701742 0.914139544123166 0.999999999999931 GO:0016836 hydro-lyase activity 6/2813 61/18639 0.0983606557377049 0.651739872838636 0.914727493819668 0.999999999999931 GO:0003954 NADH dehydrogenase activity 4/2813 44/18639 0.0909090909090909 0.60236564004783 0.915698942829579 0.999999999999931 GO:0030547 signaling receptor inhibitor activity 4/2813 44/18639 0.0909090909090909 0.60236564004783 0.915698942829579 0.999999999999931 GO:0022853 active monoatomic ion transmembrane transporter activity 13/2813 118/18639 0.110169491525424 0.729985479041014 0.919484336666296 0.999999999999931 GO:0001637 G protein-coupled chemoattractant receptor activity 2/2813 26/18639 0.0769230769230769 0.509694003117395 0.920251464816175 0.999999999999931 GO:0004950 chemokine receptor activity 2/2813 26/18639 0.0769230769230769 0.509694003117395 0.920251464816175 0.999999999999931 GO:0003730 mRNA 3'-UTR binding 32/2813 262/18639 0.122137404580153 0.809285134720748 0.922074058909814 0.999999999999931 GO:0019842 vitamin binding 17/2813 150/18639 0.113333333333333 0.750949164592961 0.924575672585144 0.999999999999931 GO:0004190 aspartic-type endopeptidase activity 3/2813 36/18639 0.0833333333333333 0.552168503377177 0.924623521415622 0.999999999999931 GO:0033293 monocarboxylic acid binding 8/2813 79/18639 0.10126582278481 0.670989573724165 0.924702794358059 0.999999999999931 GO:0061134 peptidase regulator activity 27/2813 226/18639 0.119469026548673 0.791604403071706 0.926138944850571 0.999999999999931 GO:0005024 transforming growth factor beta receptor activity 1/2813 16/18639 0.0625 0.414126377532883 0.927108050479563 0.999999999999931 GO:0005324 long-chain fatty acid transmembrane transporter activity 1/2813 16/18639 0.0625 0.414126377532883 0.927108050479563 0.999999999999931 GO:0015923 mannosidase activity 1/2813 16/18639 0.0625 0.414126377532883 0.927108050479563 0.999999999999931 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor 1/2813 16/18639 0.0625 0.414126377532883 0.927108050479563 0.999999999999931 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 1/2813 16/18639 0.0625 0.414126377532883 0.927108050479563 0.999999999999931 GO:0015399 primary active transmembrane transporter activity 19/2813 166/18639 0.114457831325301 0.758400113072268 0.927571920947154 0.999999999999931 GO:1901682 sulfur compound transmembrane transporter activity 6/2813 63/18639 0.0952380952380952 0.631049718145346 0.928905007599525 0.999999999999931 GO:0004364 glutathione transferase activity 2/2813 27/18639 0.0740740740740741 0.49081644744638 0.930159156691532 0.999999999999931 GO:0016874 ligase activity 19/2813 167/18639 0.11377245508982 0.753858795029919 0.931731735916693 0.999999999999931 GO:0098632 cell-cell adhesion mediator activity 5/2813 55/18639 0.0909090909090909 0.60236564004783 0.932841495955487 0.999999999999931 GO:0004549 tRNA-specific ribonuclease activity 1/2813 17/18639 0.0588235294117647 0.38976600238389 0.938118363211184 0.999999999999931 GO:0009881 photoreceptor activity 1/2813 17/18639 0.0588235294117647 0.38976600238389 0.938118363211184 0.999999999999931 GO:0015347 sodium-independent organic anion transmembrane transporter activity 1/2813 17/18639 0.0588235294117647 0.38976600238389 0.938118363211184 0.999999999999931 GO:0016805 dipeptidase activity 1/2813 17/18639 0.0588235294117647 0.38976600238389 0.938118363211184 0.999999999999931 GO:0030548 acetylcholine receptor regulator activity 1/2813 17/18639 0.0588235294117647 0.38976600238389 0.938118363211184 0.999999999999931 GO:0070402 NADPH binding 1/2813 17/18639 0.0588235294117647 0.38976600238389 0.938118363211184 0.999999999999931 GO:0070492 oligosaccharide binding 1/2813 17/18639 0.0588235294117647 0.38976600238389 0.938118363211184 0.999999999999931 GO:0061135 endopeptidase regulator activity 21/2813 184/18639 0.114130434782609 0.756230776364395 0.938199854862108 0.999999999999931 GO:0045499 chemorepellent activity 2/2813 28/18639 0.0714285714285714 0.473287288609009 0.938893986292178 0.999999999999931 GO:0170055 lipid transmembrane transporter activity 5/2813 56/18639 0.0892857142857143 0.591609110761262 0.939184340529922 0.999999999999931 GO:0016879 ligase activity, forming carbon-nitrogen bonds 4/2813 48/18639 0.0833333333333333 0.552168503377177 0.944919705305782 0.999999999999931 GO:0001540 amyloid-beta binding 8/2813 83/18639 0.0963855421686747 0.638652726797699 0.946159259208586 0.999999999999931 GO:0099604 ligand-gated calcium channel activity 2/2813 29/18639 0.0689655172413793 0.456967037277664 0.946584158801319 0.999999999999931 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 1/2813 18/18639 0.0555555555555556 0.368112335584785 0.9474660726026 0.999999999999931 GO:0016854 racemase and epimerase activity 1/2813 18/18639 0.0555555555555556 0.368112335584785 0.9474660726026 0.999999999999931 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 1/2813 18/18639 0.0555555555555556 0.368112335584785 0.9474660726026 0.999999999999931 GO:0017128 phospholipid scramblase activity 1/2813 18/18639 0.0555555555555556 0.368112335584785 0.9474660726026 0.999999999999931 GO:0032393 MHC class I receptor activity 1/2813 18/18639 0.0555555555555556 0.368112335584785 0.9474660726026 0.999999999999931 GO:0034185 apolipoprotein binding 1/2813 18/18639 0.0555555555555556 0.368112335584785 0.9474660726026 0.999999999999931 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 5/2813 58/18639 0.0862068965517241 0.57120879659708 0.950276767250821 0.999999999999931 GO:0005125 cytokine activity 27/2813 234/18639 0.115384615384615 0.764541004676092 0.951494483472549 0.999999999999931 GO:0098631 cell adhesion mediator activity 7/2813 76/18639 0.0921052631578947 0.61029150373267 0.952732122423193 0.999999999999931 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3/2813 40/18639 0.075 0.49695165303946 0.953047090490073 0.999999999999931 GO:0022804 active transmembrane transporter activity 57/2813 457/18639 0.12472647702407 0.826440385798664 0.953328889332596 0.999999999999931 GO:0005217 intracellularly ligand-gated monoatomic ion channel activity 2/2813 30/18639 0.0666666666666667 0.441734802701742 0.953345911370379 0.999999999999931 GO:0048019 receptor antagonist activity 2/2813 30/18639 0.0666666666666667 0.441734802701742 0.953345911370379 0.999999999999931 GO:0004222 metalloendopeptidase activity 11/2813 110/18639 0.1 0.662602204052613 0.954880552885509 0.999999999999931 GO:0003756 protein disulfide isomerase activity 1/2813 19/18639 0.0526315789473684 0.348738002132954 0.955402162918312 0.999999999999931 GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity 1/2813 19/18639 0.0526315789473684 0.348738002132954 0.955402162918312 0.999999999999931 GO:0008301 DNA binding, bending 1/2813 19/18639 0.0526315789473684 0.348738002132954 0.955402162918312 0.999999999999931 GO:0008381 mechanosensitive monoatomic ion channel activity 1/2813 19/18639 0.0526315789473684 0.348738002132954 0.955402162918312 0.999999999999931 GO:0015245 fatty acid transmembrane transporter activity 1/2813 19/18639 0.0526315789473684 0.348738002132954 0.955402162918312 0.999999999999931 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 1/2813 19/18639 0.0526315789473684 0.348738002132954 0.955402162918312 0.999999999999931 GO:0030506 ankyrin binding 1/2813 19/18639 0.0526315789473684 0.348738002132954 0.955402162918312 0.999999999999931 GO:0042834 peptidoglycan binding 1/2813 19/18639 0.0526315789473684 0.348738002132954 0.955402162918312 0.999999999999931 GO:0070003 threonine-type peptidase activity 1/2813 19/18639 0.0526315789473684 0.348738002132954 0.955402162918312 0.999999999999931 GO:0015453 oxidoreduction-driven active transmembrane transporter activity 6/2813 68/18639 0.0882352941176471 0.584649003575835 0.955632799190522 0.999999999999931 GO:0001664 G protein-coupled receptor binding 35/2813 297/18639 0.117845117845118 0.78084434821015 0.957812424858638 0.999999999999931 GO:0140828 metal cation:monoatomic cation antiporter activity 3/2813 41/18639 0.0731707317073171 0.484830881014107 0.958389423187099 0.999999999999931 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 5/2813 60/18639 0.0833333333333333 0.552168503377177 0.95949868387392 0.999999999999931 GO:0005010 insulin-like growth factor receptor activity 4/2813 51/18639 0.0784313725490196 0.51968800317852 0.96039477964012 0.999999999999931 GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity 1/2813 20/18639 0.05 0.331301102026306 0.962139741635326 0.999999999999931 GO:0030627 pre-mRNA 5'-splice site binding 1/2813 20/18639 0.05 0.331301102026306 0.962139741635326 0.999999999999931 GO:0140664 ATP-dependent DNA damage sensor activity 1/2813 20/18639 0.05 0.331301102026306 0.962139741635326 0.999999999999931 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 5/2813 61/18639 0.0819672131147541 0.543116560698863 0.963496111557335 0.999999999999931 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2/2813 32/18639 0.0625 0.414126377532883 0.964493475302767 0.999999999999931 GO:0042910 xenobiotic transmembrane transporter activity 2/2813 32/18639 0.0625 0.414126377532883 0.964493475302767 0.999999999999931 GO:0016651 oxidoreductase activity, acting on NAD(P)H 8/2813 88/18639 0.0909090909090909 0.60236564004783 0.965254803851894 0.999999999999931 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3/2813 43/18639 0.0697674418604651 0.462280607478567 0.967406834860732 0.999999999999931 GO:0001846 opsonin binding 1/2813 21/18639 0.0476190476190476 0.315524859072673 0.967859753815348 0.999999999999931 GO:0009975 cyclase activity 1/2813 21/18639 0.0476190476190476 0.315524859072673 0.967859753815348 0.999999999999931 GO:0015125 bile acid transmembrane transporter activity 1/2813 21/18639 0.0476190476190476 0.315524859072673 0.967859753815348 0.999999999999931 GO:0036122 BMP binding 1/2813 21/18639 0.0476190476190476 0.315524859072673 0.967859753815348 0.999999999999931 GO:0051428 peptide hormone receptor binding 1/2813 21/18639 0.0476190476190476 0.315524859072673 0.967859753815348 0.999999999999931 GO:0008146 sulfotransferase activity 4/2813 53/18639 0.0754716981132075 0.500077135134048 0.968357533101491 0.999999999999931 GO:0038064 collagen receptor activity 4/2813 53/18639 0.0754716981132075 0.500077135134048 0.968357533101491 0.999999999999931 GO:0042923 neuropeptide binding 2/2813 33/18639 0.0606060606060606 0.40157709336522 0.969058425217281 0.999999999999931 GO:0030020 extracellular matrix structural constituent conferring tensile strength 3/2813 44/18639 0.0681818181818182 0.451774230035872 0.971190339155694 0.999999999999931 GO:0009055 electron transfer activity 11/2813 116/18639 0.0948275862068965 0.628329676256788 0.972047687676578 0.999999999999931 GO:0016881 acid-amino acid ligase activity 1/2813 22/18639 0.0454545454545455 0.301182820023915 0.972715834625178 0.999999999999931 GO:0030021 extracellular matrix structural constituent conferring compression resistance 1/2813 22/18639 0.0454545454545455 0.301182820023915 0.972715834625178 0.999999999999931 GO:0033691 sialic acid binding 1/2813 22/18639 0.0454545454545455 0.301182820023915 0.972715834625178 0.999999999999931 GO:0019825 oxygen binding 2/2813 34/18639 0.0588235294117647 0.38976600238389 0.97305480351711 0.999999999999931 GO:0016229 steroid dehydrogenase activity 2/2813 35/18639 0.0571428571428571 0.378629830887207 0.976550180552438 0.999999999999931 GO:0140103 catalytic activity, acting on a glycoprotein 1/2813 23/18639 0.0434782608695652 0.288087914805484 0.976838429951997 0.999999999999931 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 3/2813 46/18639 0.0652173913043478 0.432131872208226 0.977544094500227 0.999999999999931 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 3/2813 46/18639 0.0652173913043478 0.432131872208226 0.977544094500227 0.999999999999931 GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity 2/2813 36/18639 0.0555555555555556 0.368112335584785 0.979604689913428 0.999999999999931 GO:0005540 hyaluronic acid binding 1/2813 24/18639 0.0416666666666667 0.276084251688589 0.980338295473324 0.999999999999931 GO:0050431 transforming growth factor beta binding 1/2813 24/18639 0.0416666666666667 0.276084251688589 0.980338295473324 0.999999999999931 GO:0031406 carboxylic acid binding 19/2813 187/18639 0.101604278074866 0.67323218593581 0.981304430851254 0.999999999999931 GO:0022829 wide pore channel activity 2/2813 37/18639 0.0540540540540541 0.358163353541953 0.982271733210338 0.999999999999931 GO:0030280 structural constituent of skin epidermis 2/2813 37/18639 0.0540540540540541 0.358163353541953 0.982271733210338 0.999999999999931 GO:0038187 pattern recognition receptor activity 3/2813 48/18639 0.0625 0.414126377532883 0.982548544609722 0.999999999999931 GO:0001848 complement binding 1/2813 25/18639 0.04 0.265040881621045 0.983309467905961 0.999999999999931 GO:0043177 organic acid binding 19/2813 189/18639 0.100529100529101 0.666108035820087 0.98375536573123 0.999999999999931 GO:0005501 retinoid binding 2/2813 38/18639 0.0526315789473684 0.348738002132954 0.984598641586312 0.999999999999931 GO:0019840 isoprenoid binding 2/2813 38/18639 0.0526315789473684 0.348738002132954 0.984598641586312 0.999999999999931 GO:0005004 GPI-linked ephrin receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0005008 hepatocyte growth factor receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0005009 insulin receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0005011 macrophage colony-stimulating factor receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0005018 platelet-derived growth factor alpha-receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0005020 stem cell factor receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0008288 boss receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0036332 placental growth factor receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0038062 protein tyrosine kinase collagen receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0060175 brain-derived neurotrophic factor receptor activity 3/2813 49/18639 0.0612244897959184 0.405674818807722 0.984631672887274 0.999999999999931 GO:0033218 amide binding 26/2813 247/18639 0.105263157894737 0.697476004265908 0.985768176885099 0.999999999999931 GO:0004714 transmembrane receptor protein tyrosine kinase activity 4/2813 60/18639 0.0666666666666667 0.441734802701742 0.985938060495555 0.999999999999931 GO:0005006 epidermal growth factor receptor activity 3/2813 50/18639 0.06 0.397561322431568 0.986475167384165 0.999999999999931 GO:0005007 fibroblast growth factor receptor activity 3/2813 50/18639 0.06 0.397561322431568 0.986475167384165 0.999999999999931 GO:0005017 platelet-derived growth factor receptor activity 3/2813 50/18639 0.06 0.397561322431568 0.986475167384165 0.999999999999931 GO:0005019 platelet-derived growth factor beta-receptor activity 3/2813 50/18639 0.06 0.397561322431568 0.986475167384165 0.999999999999931 GO:0140299 molecular sensor activity 5/2813 71/18639 0.0704225352112676 0.466621270459587 0.987643359608904 0.999999999999931 GO:0008395 steroid hydroxylase activity 1/2813 27/18639 0.037037037037037 0.24540822372319 0.987973043081015 0.999999999999931 GO:0005021 vascular endothelial growth factor receptor activity 3/2813 51/18639 0.0588235294117647 0.38976600238389 0.988105191618168 0.999999999999931 GO:0005030 neurotrophin receptor activity 3/2813 51/18639 0.0588235294117647 0.38976600238389 0.988105191618168 0.999999999999931 GO:0004866 endopeptidase inhibitor activity 15/2813 161/18639 0.093167701863354 0.617331246011751 0.98883556790143 0.999999999999931 GO:0005003 ephrin receptor activity 3/2813 53/18639 0.0566037735849057 0.375057851350536 0.99081653883355 0.999999999999931 GO:0005005 transmembrane-ephrin receptor activity 3/2813 53/18639 0.0566037735849057 0.375057851350536 0.99081653883355 0.999999999999931 GO:0015081 sodium ion transmembrane transporter activity 15/2813 164/18639 0.0914634146341463 0.606038601267634 0.99122362907402 0.999999999999931 GO:0005262 calcium channel activity 11/2813 131/18639 0.083969465648855 0.556383530120515 0.992346428835947 0.999999999999931 GO:0005245 voltage-gated calcium channel activity 2/2813 43/18639 0.0465116279069767 0.308187071652378 0.992436378037224 0.999999999999931 GO:0016500 protein-hormone receptor activity 4/2813 67/18639 0.0597014925373134 0.395583405404545 0.99395866230515 0.999999999999931 GO:0030414 peptidase inhibitor activity 15/2813 169/18639 0.0887573964497041 0.588108465135455 0.99417962573615 0.999999999999931 GO:0019199 transmembrane receptor protein kinase activity 5/2813 78/18639 0.0641025641025641 0.424745002597829 0.994443925674598 0.999999999999931 GO:0008083 growth factor activity 14/2813 162/18639 0.0864197530864197 0.572619188687443 0.994937357681239 0.999999999999931 GO:0005506 iron ion binding 13/2813 154/18639 0.0844155844155844 0.559339522901556 0.995258815284319 0.999999999999931 GO:0001653 peptide receptor activity 10/2813 128/18639 0.078125 0.517657971916104 0.995630626998793 0.999999999999931 GO:0016798 hydrolase activity, acting on glycosyl bonds 10/2813 130/18639 0.0769230769230769 0.509694003117395 0.99640112790267 0.999999999999931 GO:0008528 G protein-coupled peptide receptor activity 9/2813 122/18639 0.0737704918032787 0.488804904628977 0.996835088793881 0.999999999999931 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 9/2813 122/18639 0.0737704918032787 0.488804904628977 0.996835088793881 0.999999999999931 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 10/2813 132/18639 0.0757575757575758 0.501971366706525 0.997041552565672 0.999999999999931 GO:0005109 frizzled binding 1/2813 38/18639 0.0263157894736842 0.174369001066477 0.998017883097139 0.999999999999931 GO:0038024 cargo receptor activity 3/2813 65/18639 0.0461538461538462 0.305816401870437 0.998139344793863 0.999999999999931 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential 2/2813 53/18639 0.0377358490566038 0.250038567567024 0.998230966908737 0.999999999999931 GO:0015103 inorganic anion transmembrane transporter activity 13/2813 165/18639 0.0787878787878788 0.522050221374786 0.998256413517566 0.999999999999931 GO:0008509 monoatomic anion transmembrane transporter activity 11/2813 149/18639 0.0738255033557047 0.489169412387835 0.998616523054294 0.999999999999931 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 5/2813 91/18639 0.0549450549450549 0.364067145083853 0.998827298074397 0.999999999999931 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential 2/2813 56/18639 0.0357142857142857 0.236643644304505 0.998863252446275 0.999999999999931 GO:0017171 serine hydrolase activity 16/2813 198/18639 0.0808080808080808 0.53543612448696 0.998992324340386 0.999999999999931 GO:0005253 monoatomic anion channel activity 6/2813 103/18639 0.058252427184466 0.385981866438415 0.999008874519575 0.999999999999931 GO:0004497 monooxygenase activity 6/2813 106/18639 0.0566037735849057 0.375057851350536 0.99930584457338 0.999999999999931 GO:0008236 serine-type peptidase activity 15/2813 194/18639 0.077319587628866 0.512321291793257 0.999364562668815 0.999999999999931 GO:0015078 proton transmembrane transporter activity 14/2813 185/18639 0.0756756756756757 0.501428694958734 0.999374528507823 0.999999999999931 GO:0022824 transmitter-gated monoatomic ion channel activity 2/2813 63/18639 0.0317460317460317 0.210349906048449 0.999598668424996 0.999999999999931 GO:0022835 transmitter-gated channel activity 2/2813 63/18639 0.0317460317460317 0.210349906048449 0.999598668424996 0.999999999999931 GO:0008188 neuropeptide receptor activity 1/2813 48/18639 0.0208333333333333 0.138042125844294 0.999615540810134 0.999999999999931 GO:0008201 heparin binding 12/2813 172/18639 0.0697674418604651 0.462280607478567 0.999645671628809 0.999999999999931 GO:1901681 sulfur compound binding 23/2813 275/18639 0.0836363636363636 0.554176388844003 0.999728396992937 0.999999999999931 GO:0004252 serine-type endopeptidase activity 12/2813 176/18639 0.0681818181818182 0.451774230035872 0.999764965853364 0.999999999999931 GO:0005201 extracellular matrix structural constituent 11/2813 168/18639 0.0654761904761905 0.433846681224925 0.99980409270794 0.999999999999931 GO:0098960 postsynaptic neurotransmitter receptor activity 2/2813 69/18639 0.0289855072463768 0.192058609870323 0.999837022980929 0.999999999999931 GO:0046906 tetrapyrrole binding 9/2813 152/18639 0.0592105263157895 0.392330252399573 0.999874899016874 0.999999999999931 GO:0005230 extracellular ligand-gated monoatomic ion channel activity 2/2813 73/18639 0.0273972602739726 0.181534850425373 0.999910970607451 0.999999999999931 GO:0046873 metal ion transmembrane transporter activity 41/2813 450/18639 0.0911111111111111 0.603704230359047 0.999948185886712 0.999999999999931 GO:0020037 heme binding 7/2813 142/18639 0.0492957746478873 0.326634889321711 0.99996739250008 0.999999999999931 GO:0004867 serine-type endopeptidase inhibitor activity 3/2813 95/18639 0.0315789473684211 0.209242801279772 0.999972614493991 0.999999999999931 GO:0015108 chloride transmembrane transporter activity 5/2813 121/18639 0.0413223140495868 0.273802563658104 0.99997493851563 0.999999999999931 GO:0005254 chloride channel activity 2/2813 83/18639 0.0240963855421687 0.159663181699425 0.999980588285957 0.999999999999931 GO:0005539 glycosaminoglycan binding 16/2813 242/18639 0.0661157024793388 0.438084101852967 0.999985905151257 0.999999999999931 GO:0015079 potassium ion transmembrane transporter activity 7/2813 160/18639 0.04375 0.289888464273018 0.999996627367228 0.999999999999931 GO:0005244 voltage-gated monoatomic ion channel activity 8/2813 173/18639 0.046242774566474 0.306405643492538 0.999997214682376 0.999999999999931 GO:0030594 neurotransmitter receptor activity 2/2813 97/18639 0.0206185567010309 0.136619011144869 0.999997749868042 0.999999999999931 GO:0022832 voltage-gated channel activity 8/2813 175/18639 0.0457142857142857 0.302903864709766 0.999997833072807 0.999999999999931 GO:0005249 voltage-gated potassium channel activity 2/2813 98/18639 0.0204081632653061 0.135224939602574 0.999998072513392 0.999999999999931 GO:0099094 ligand-gated monoatomic cation channel activity 4/2813 136/18639 0.0294117647058824 0.194883001191945 0.999999466788669 0.999999999999931 GO:0022843 voltage-gated monoatomic cation channel activity 4/2813 143/18639 0.027972027972028 0.185343273860871 0.999999805412736 0.999999999999931 GO:0005179 hormone activity 3/2813 132/18639 0.0227272727272727 0.150591410011957 0.999999883688384 0.999999999999931 GO:0005267 potassium channel activity 2/2813 124/18639 0.0161290322580645 0.106871323234292 0.999999966609929 0.999999999999931 GO:0022834 ligand-gated channel activity 6/2813 188/18639 0.0319148936170213 0.21146878852743 0.999999984900805 0.999999999999931 GO:0015276 ligand-gated monoatomic ion channel activity 5/2813 186/18639 0.0268817204301075 0.178118872057154 0.99999999705344 0.999999999999931 GO:0022836 gated channel activity 15/2813 318/18639 0.0471698113207547 0.31254820945878 0.999999999224912 0.999999999999931 GO:0005261 monoatomic cation channel activity 15/2813 341/18639 0.0439882697947214 0.291467245184434 0.999999999954754 0.999999999999931 GO:0045182 translation regulator activity 15/2813 356/18639 0.0421348314606742 0.279186321932281 0.999999999993165 0.999999999999931 GO:0005216 monoatomic ion channel activity 23/2813 448/18639 0.0513392857142857 0.340175238687725 0.999999999995368 0.999999999999931 GO:0030371 translation repressor activity 10/2813 329/18639 0.0303951367781155 0.2013988462166 0.999999999999931 0.999999999999931