category	subcategory	ID	Description	GeneRatio	BgRatio	FoldEnrichment	geneName	zScore
Human Diseases	Infectious disease: viral	hsa05169	Epstein-Barr virus infection	106/2187	205/9376	2.21677094137197	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/CDKN1A/HLA-DPA1/TNFAIP3/HLA-DMA/NCOR2/MAP2K3/TRAF3/CD44/CD58/VIM/BCL2/HLA-DRA/NFKBIA/HLA-DOA/HLA-A/HLA-B/NFKB1/NFKB2/HLA-F/PIK3CB/RELB/OAS2/AKT3/HLA-DMB/RUNX3/STAT1/BID/NFKBIE/HES1/HLA-E/IRF7/EIF2AK2/HLA-DQB2/TAB2/GADD45A/GADD45G/IL6/IRAK1/HLA-C/JAK1/MAPK13/TBK1/OAS3/GADD45B/USP7/CYCS/BCL2L11/RIPK1/MDM2/ISG15/PIK3R1/PSMD14/PSMD12/TNF/PLCG2/PSMD11/B2M/TAPBP/CD40/PDIA3/TAP1/FAS/PSMD7/NFKBIB/MYD88/CASP8/ICAM1/RELA/SIN3A/IFNAR2/IRF9/PSMD1/TAP2/SNW1/BTK/ENTPD1/IFNAR1/MAPK8/OAS1/STAT2/SAP30/DDB2/TRAF6/TLR2/CASP3/HLA-G/TAPBPL/MYC/E2F3/MAP2K4/PIK3R3/STAT3/CXCL10/MAP3K14/CCND3/TRAF2/CASP9/TRAF5/CCNE2/MAPK10	9.71523256256288
Human Diseases	Infectious disease: viral	hsa05168	Herpes simplex virus 1 infection	94/2187	180/9376	2.23884570441498	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/IL1B/HLA-DMA/ITGA5/TRAF3/PILRA/BCL2/C3/HLA-DRA/NFKBIA/HLA-DOA/SRC/CD74/HLA-A/HLA-B/NFKB1/HLA-F/PIK3CB/BIRC3/IFIH1/NXF1/OAS2/AKT3/HLA-DMB/STAT1/BID/TICAM1/BIRC2/HLA-E/IRF7/EIF2AK2/HLA-DQB2/TAB2/IL6/ZC3HAV1/IRAK1/RHEB/HLA-C/JAK1/TBK1/OAS3/CGAS/CYCS/TNFSF14/PIK3R1/TNF/B2M/TAPBP/PDIA3/TAP1/FAS/SRSF2/MYD88/CASP8/RELA/TNFRSF14/NECTIN2/IFNAR2/IRF9/SRSF4/SRSF5/IFNGR2/TAP2/PTPN11/IFNAR1/PILRB/OAS1/SRSF3/STAT2/ITGB3/EIF2S1/TRAF6/SRPK1/TLR2/CASP3/HLA-G/TAPBPL/POU2F1/BCL2L1/IFNGR1/NECTIN1/CFP/PIK3R3/SP100/TRAF2/CASP9/TRAF5/SRSF7	9.25613709549505
Human Diseases	Infectious disease: parasitic	hsa05145	Toxoplasmosis	64/2187	112/9376	2.44980077078842	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/MAP2K3/PIK3R5/BCL2/PPIF/HLA-DRA/CIITA/NFKBIA/HLA-DOA/NFKB1/BIRC3/AKT3/HLA-DMB/STAT1/HSPA6/BIRC2/HLA-DQB2/TAB2/IRAK1/JAK1/MAPK13/CYCS/CCR5/IL10/TNF/SOCS1/LDLR/CD40/TGFB1/LAMB3/NFKBIB/MYD88/CASP8/RELA/IFNGR2/IL10RA/HSPA8/PIK3R6/HSPA1B/MAPK8/PDPK1/MAPK1/TRAF6/TLR2/CASP3/GNAI3/HSPA1A/HSPA1L/BCL2L1/IFNGR1/STAT3/CASP9/ALOX5/LAMA3/TGFB2/MAPK10/LAMB1	8.51321991611373
Human Diseases	Infectious disease: bacterial	hsa05152	Tuberculosis	88/2187	181/9376	2.08436087680341	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/ITGAX/HLA-DQA2/HLA-DPA1/IL1B/HLA-DMA/IRAK2/BCL2/C3/SPHK1/HLA-DRA/CIITA/FCGR2B/HLA-DOA/SRC/IL1A/CD74/NFKB1/PLK3/ATP6V1H/MALT1/CTSS/AKT3/HLA-DMB/RAB7A/STAT1/BID/VDR/IL18/CLEC4E/HLA-DQB2/CTSD/IL6/IRAK1/RIPK2/JAK1/MAPK13/LSP1/RAB5A/CYCS/RAF1/HSPA9/BCL10/NOD2/IL10/TNF/CREBBP/IL23A/PPP3CC/HSPD1/TGFB1/EP300/MYD88/CASP8/RELA/RHOA/ATP6V0D1/LAMP2/IFNGR2/CEBPG/IL10RA/TLR1/MAPK8/MAPK1/TRAF6/TCIRG1/TLR2/CASP3/NFYC/RFX5/FCGR2A/CEBPB/KSR1/CLEC7A/IFNGR1/ITGB2/ITGAM/CALM1/CAMK2D/ATP6V0D2/CASP9/CAMP/TGFB2/MAPK10	8.1248069113315
Organismal Systems	Development and regeneration	hsa04380	Osteoclast differentiation	73/2187	142/9376	2.20395808780438	IL1B/FOSL1/FCGR2B/NFKBIA/IL1A/NFKB1/ITPR1/NFKB2/MAP2K1/PIK3CB/TREM2/RELB/CYLD/AKT3/STAT1/ACP5/TAB2/NFATC1/JAK1/MAPK13/IL1R1/ATP2A2/OSCAR/FOSL2/LCP2/LILRB2/PIK3R1/FYN/TNF/LILRB4/SOCS1/LILRB1/PLCG2/PPP3CC/TGFB1/SIRPA/RELA/IFNAR2/IRF9/IFNGR2/SQSTM1/PPARG/LILRA6/BTK/IFNAR1/MAPK8/GRB2/STAT2/MAPK1/ITGB3/ATP2A3/TYROBP/TRAF6/LILRA5/FCGR2A/LILRA2/NCF2/SPI1/GAB2/LILRB3/IFNGR1/LILRA1/PIK3R3/FOSB/MAP3K14/LILRA4/NCF1/TRAF2/ATP2A1/SIRPB1/TGFB2/MAPK10/JUND	7.97326857901166
Human Diseases	Cardiovascular disease	hsa05417	Lipid and atherosclerosis	98/2187	216/9376	1.94509644532507	CXCL3/IL1B/OLR1/ERN1/CXCL2/MAP2K3/TRAF3/BCL2/NFKBIA/SOD2/SRC/NFKB1/ITPR1/EIF2AK3/PIK3CB/CXCL8/AKT3/NFE2L2/BID/HSPA5/TICAM1/HSPA6/IL18/CXCL1/ABCG1/IRF7/TAB2/NFATC1/DDIT3/IL6/HSP90AB1/IRAK1/MAPK13/TBK1/MMP9/ATF4/ERO1A/CYCS/ABCA1/TANK/PIK3R1/TNF/HSP90AA1/LDLR/CD40/FAS/PPP3CC/CASP1/HSPD1/MYD88/KRAS/CASP8/ICAM1/RELA/RHOA/TNFRSF10A/TNFRSF10B/PPARG/APOA1/HSPA8/NRAS/HSPA1B/APOB/MAPK8/HSPA4/PDPK1/RAP1B/CDC42/MAPK1/EIF2S1/RXRA/TRAF6/TLR2/CASP3/HSPA1A/TICAM2/HSPA1L/NCF2/RAP1A/POU2F1/MAP2K4/GSK3B/BCL2L1/MAP3K5/HSPA2/PIK3R3/STAT3/CALM1/CAMK2D/XBP1/VAV2/NCF1/TRAF2/CASP9/ATF6/CCL3/MAPK10/CCL3L1	7.75052383832368
Human Diseases	Infectious disease: bacterial	hsa05134	Legionellosis	38/2187	56/9376	2.90913841531126	CXCL3/IL1B/CXCL2/C3/NFKBIA/NFKB1/NFKB2/CXCL8/HSPA6/IL18/CXCL1/IL6/CYCS/BCL2L13/TNF/CASP1/CLK1/HSPD1/MYD88/SEC22B/CASP8/RELA/HSPA8/SAR1A/HSPA1B/HBS1L/ARF1/HSF1/TLR2/CASP3/HSPA1A/HSPA1L/EEF1A1/RAB1A/ITGB2/ITGAM/TLR5/CASP9	7.903132474332
Human Diseases	Infectious disease: viral	hsa05167	Kaposi sarcoma-associated herpesvirus infection	89/2187	196/9376	1.94671668393009	CDKN1A/CXCL3/VEGFA/CXCL2/TRAF3/PTGS2/PIK3R5/C3/NFKBIA/SRC/HLA-A/HLA-B/UBC/NFKB1/ITPR1/MAPKAPK2/HLA-F/MAP2K1/PIK3CB/CXCL8/AKT3/STAT1/BID/TICAM1/CXCL1/HLA-E/IRF7/EIF2AK2/NFATC1/IL6/HLA-C/JAK1/MAPK13/TBK1/MAP1LC3B/CSF2/CYCS/CLEC2B/RAF1/TCF7/CCR5/PIK3R1/PLCG2/CREBBP/FAS/PPP3CC/EP300/KRAS/CASP8/ICAM1/RELA/IFNAR2/IRF9/GNB1/NRAS/PIK3R6/TCF7L2/BECN1/IFNAR1/MAPK8/PDGFB/ZFP36/CTNNB1/STAT2/GNB4/MAPK1/GNGT2/GNG4/CASP3/HLA-G/PREX1/MYC/E2F3/CCR3/MAP2K4/GSK3B/IFNGR1/PIK3R3/MAP1LC3B2/STAT3/CALM1/GNG7/TRAF2/CASP9/GNG5/MICB/GNB5/MAPK10/HIF1A	7.38758538956399
Human Diseases	Infectious disease: viral	hsa05164	Influenza A	79/2187	173/9376	1.95771651191618	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/IL1B/HLA-DMA/TRAF3/MX1/MX2/HLA-DRA/CIITA/NFKBIA/HLA-DOA/IL1A/NFKB1/MAP2K1/PIK3CB/CXCL8/IFIH1/NXF1/OAS2/AKT3/HLA-DMB/STAT1/BID/DNAJB1/TICAM1/DNAJC3/IL18/IRF7/EIF2AK2/HLA-DQB2/IL6/JAK1/TBK1/TRIM25/ADAR/OAS3/CYCS/RAF1/PIK3R1/RSAD2/TNF/NUP98/CREBBP/NXT2/KPNA2/FAS/CASP1/EP300/NFKBIB/MYD88/HNRNPUL1/CASP8/ICAM1/RELA/TNFRSF10A/IFNAR2/IRF9/IFNGR2/TNFRSF10B/IFNAR1/CALCOCO2/NXT1/OAS1/STAT2/MAPK1/EIF2S1/CASP3/RAB11A/IFNGR1/PIK3R3/CXCL10/CCND3/PRKCB/CASP9	7.01247140913499
Human Diseases	Infectious disease: parasitic	hsa05140	Leishmaniasis	45/2187	78/9376	2.47335654743062	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/IL1B/HLA-DMA/PTGS2/C3/HLA-DRA/NFKBIA/HLA-DOA/IL1A/NFKB1/HLA-DMB/STAT1/HLA-DQB2/TAB2/MARCKSL1/IRAK1/JAK1/MAPK13/ITGA4/IL10/TNF/TGFB1/NFKBIB/MYD88/RELA/IFNGR2/MAPK1/TRAF6/TLR2/FCGR2A/EEF1A1/NCF2/ELK1/IFNGR1/ITGB2/ITGAM/NCF1/PRKCB/TGFB2	7.20669555403052
Human Diseases	Infectious disease: viral	hsa05161	Hepatitis B	75/2187	163/9376	1.97261565132504	CDKN1A/MAP2K3/TRAF3/BCL2/STAT4/NFKBIA/SRC/NFKB1/PTK2B/MAP2K1/PIK3CB/CXCL8/IFIH1/AKT3/STAT1/BID/TICAM1/IRF7/TAB2/NFATC1/CREB5/IL6/IRAK1/JAK1/MAPK13/TBK1/MMP9/ATF4/CYCS/STAT5A/RAF1/PIK3R1/TNF/YWHAQ/SMAD3/CREBBP/FAS/TGFB1/EP300/MYD88/KRAS/CASP8/RELA/NRAS/IFNAR1/YWHAZ/MAPK8/DDB1/PRKCG/GRB2/STAT2/MAPK1/DDB2/BRAF/TRAF6/TLR2/CASP3/SLC10A1/ATF2/TICAM2/MYC/EGR3/ELK1/E2F3/STAT6/STAT5B/MAP2K4/PIK3R3/STAT3/PRKCB/CASP9/DDX3X/CCNE2/TGFB2/MAPK10	6.9089222998804
Organismal Systems	Immune system	hsa04612	Antigen processing and presentation	46/2187	82/9376	2.40498734205449	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/IFI30/HLA-DRA/CIITA/HLA-DOA/CD74/HLA-A/HLA-B/HLA-F/CTSS/HLA-DMB/HSPA5/HSPA6/HLA-E/HLA-DQB2/HSP90AB1/HLA-C/CTSB/TNF/HSP90AA1/B2M/TAPBP/PDIA3/TAP1/CANX/TAP2/HSPA8/HSPA1B/HSPA4/PSME1/HLA-G/NFYC/TAPBPL/RFX5/HSPA1A/HSPA1L/KLRD1/CTSL/HSPA2	7.04780357478536
Human Diseases	Infectious disease: viral	hsa05163	Human cytomegalovirus infection	95/2187	227/9376	1.79418228257082	CXCR4/CDKN1A/VEGFA/IL1B/PTGS2/NFKBIA/SRC/HLA-A/HLA-B/NFKB1/ITPR1/PTK2B/HLA-F/IL6R/MAP2K1/PIK3CB/CXCL8/AKT3/ITGAV/BID/GNA12/ADCY3/HLA-E/NFATC1/CREB5/IL6/AKAP13/RHEB/HLA-C/JAK1/MAPK13/TBK1/PTGER4/IL1R1/ATF4/PTGER2/CGAS/CYCS/RIPK1/RAF1/MDM2/CCR5/PIK3R1/TNF/GNA13/B2M/TAPBP/PDIA3/TAP1/FAS/PPP3CC/KRAS/CASP8/RELA/RHOA/GNB1/TAP2/IL10RA/NRAS/PRKCG/CTNNB1/GRB2/GNB4/MAPK1/ITGB3/GNGT2/RPS6KB1/GNG4/CASP3/HLA-G/ADCY9/TAPBPL/GNAI3/ATF2/MYC/CXCL12/ELK1/E2F3/CCR3/GSK3B/GNAQ/PIK3R3/STAT3/CALM1/GNG7/SP1/PTGER3/TRAF2/PRKCB/CASP9/GNG5/TRAF5/GNB5/CCL3/CCL3L1	6.68070195164659
Environmental Information Processing	Signal transduction	hsa04668	TNF signaling pathway	59/2187	119/9376	2.12556243347819	TNFAIP3/CXCL3/IL1B/CXCL2/MAP2K3/TRAF3/PTGS2/TRAF1/IRF1/CCL20/NFKBIA/NFKB1/MAP2K1/PIK3CB/BIRC3/IL15/CYLD/AKT3/CFLAR/CXCL1/BIRC2/TAB2/CREB5/IL6/BCL3/MAPK13/ADAM17/MMP9/ATF4/CSF2/RIPK1/PIK3R1/NOD2/TNF/FAS/CASP8/ICAM1/RELA/TNFRSF1B/MAPK8/MAPK1/JAG1/CXCL5/CASP3/FRMD8/MLKL/TAB3/ATF2/CEBPB/LIF/MAP2K4/EDN1/MAP3K5/PIK3R3/CXCL10/MAP3K14/TRAF2/TRAF5/MAPK10	6.8152803662562
Cellular Processes	Transport and catabolism	hsa04140	Autophagy - animal	76/2187	169/9376	1.92794971902284	ERN1/BCL2/MRAS/UBC/ITPR1/EIF2AK3/MAP2K1/PIK3CB/AKT3/RAB7A/CFLAR/GABARAPL1/CTSD/DDIT4/RHEB/TBK1/MAP1LC3B/RB1CC1/RAB7B/RRAGD/TANK/EPG5/CTSB/RAF1/IRS2/MTMR3/PIK3R1/RAB8A/PPP2CA/CAMKK2/ATG13/C9orf72/RPTOR/PLEKHM1/RRAGC/KRAS/LAMP2/TP53INP2/SQSTM1/ATG4B/IGBP1/ZFYVE1/ATG101/NRAS/BECN1/CALCOCO2/MAPK8/PDPK1/EIF2AK4/ATG16L1/ATG12/MAPK1/EIF2S1/PRKCD/MTMR14/TRAF6/RPS6KB1/PTEN/VMP1/CTSL/TAX1BP1/AKT1S1/BCL2L1/ATG2A/RAB1A/PIK3R3/MAP1LC3B2/ATG16L2/ATG4A/DAPK1/WIPI1/ULK1/ATG2B/MAPK10/HIF1A/IGF1R	6.71404910485977
Human Diseases	Immune disease	hsa05323	Rheumatoid arthritis	50/2187	95/9376	2.25639544677881	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/CXCL3/VEGFA/IL1B/HLA-DMA/CXCL2/HLA-DRA/CCL20/HLA-DOA/IL1A/ATP6V1H/CD80/CXCL8/IL15/HLA-DMB/IL18/CXCL1/ACP5/HLA-DQB2/IL6/TNFSF13B/CSF2/TNFSF13/TNF/IL23A/ATP6V1A/TGFB1/ICAM1/ATP6V0D1/ATP6V1B2/ATP6V1C1/ATP6V1E1/TCIRG1/CXCL5/TLR2/ATP6V1F/CXCL12/CTSL/ITGB2/ATP6V0D2/ATP6V1E2/TGFB2/CCL3/CCL3L1	6.78838645218088
Environmental Information Processing	Signal transduction	hsa04064	NF-kappa B signaling pathway	53/2187	105/9376	2.16399068086311	TNFAIP3/CXCL3/IL1B/CXCL2/TRAF3/PTGS2/TRAF1/BCL2/NFKBIA/NFKB1/NFKB2/MALT1/CXCL8/BIRC3/RELB/CYLD/PLAU/CCL21/CFLAR/TICAM1/CXCL1/BIRC2/TAB2/GADD45A/GADD45G/TNFSF13B/IRAK1/BCL2A1/IL1R1/TRIM25/GADD45B/RIPK1/TNFSF14/BCL10/TNF/PLCG2/CD40/MYD88/ICAM1/RELA/BTK/TRAF6/CARD11/TAB3/TICAM2/CXCL12/LAT/BCL2L1/PPP1R13L/MAP3K14/TRAF2/PRKCB/TRAF5	6.61540824488539
Cellular Processes	Cell growth and death	hsa04210	Apoptosis	64/2187	137/9376	2.00275683451316	ERN1/TRAF1/IL3RA/BCL2/NFKBIA/NFKB1/ITPR1/CAPN2/CTSH/EIF2AK3/CTSS/MAP2K1/PIK3CB/BIRC3/LMNA/AKT3/CFLAR/BID/BIRC2/GADD45A/GADD45G/CTSD/DDIT3/BCL2A1/TUBA1C/ATF4/GADD45B/CYCS/BCL2L11/RIPK1/CTSB/RAF1/PMAIP1/MCL1/PIK3R1/TNF/TUBA4A/FAS/KRAS/CASP8/RELA/TNFRSF10A/TNFRSF10B/NRAS/MAPK8/SPTAN1/PDPK1/MAPK1/EIF2S1/CASP3/AIFM1/CTSZ/LMNB1/CTSL/BCL2L1/CTSV/MAP3K5/PIK3R3/MAP3K14/TRAF2/CASP9/NTRK1/DIABLO/MAPK10	6.52107535285951
Organismal Systems	Immune system	hsa04659	Th17 cell differentiation	54/2187	109/9376	2.12390984256428	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/IL1B/HLA-DMA/AHR/HLA-DRA/NFKBIA/HLA-DOA/NFKB1/IL6R/HLA-DMB/RARA/STAT1/NFKBIE/HLA-DQB2/NFATC1/IL6/HSP90AB1/IRF4/JAK1/MAPK13/IL1R1/STAT5A/IL1RAP/HSP90AA1/SMAD3/IL23A/PPP3CC/IL2RG/IL4R/TGFB1/NFKBIB/RELA/IFNGR2/SMAD2/MAPK8/MAPK1/RXRA/IL2RA/STAT6/STAT5B/LAT/IL12RB1/IFNGR1/STAT3/IL27RA/IL27/MAPK10/HIF1A	6.50954944143069
Human Diseases	Immune disease	hsa05321	Inflammatory bowel disease	38/2187	66/9376	2.46835986753682	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/IL1B/HLA-DMA/HLA-DRA/STAT4/HLA-DOA/IL1A/NFKB1/HLA-DMB/STAT1/IL18/HLA-DQB2/NFATC1/IL6/NOD2/IL10/TNF/SMAD3/IL23A/IL2RG/IL4R/TGFB1/RELA/IFNGR2/SMAD2/TLR2/STAT6/IL12RB1/IFNGR1/STAT3/TLR5/TGFB2	6.60245456490868
Organismal Systems	Immune system	hsa04621	NOD-like receptor signaling pathway	80/2187	187/9376	1.83407544337101	TNFAIP3/CXCL3/IL1B/CXCL2/TRAF3/BCL2/NFKBIA/NFKB1/ITPR1/GBP2/CXCL8/BIRC3/OAS2/STAT1/GABARAPL1/TICAM1/IL18/CXCL1/BIRC2/GBP4/IRF7/TAB2/IL6/HSP90AB1/RIPK2/GBP1/JAK1/MAPK13/TBK1/TXN/GBP5/MAP1LC3B/OAS3/TANK/ERBIN/P2RX7/RIPK1/CTSB/NOD2/TNF/HSP90AA1/CASP1/NFKBIB/MYD88/CASP8/RELA/RHOA/IFNAR2/IRF9/NAMPT/PANX1/IFNAR1/MAPK8/ATG16L1/OAS1/ATG12/STAT2/MAPK1/PRKCD/TRAF6/MCU/TRPV2/AIM2/TAB3/MFN1/GBP3/TRPM7/BCL2L1/MAP1LC3B2/TRAF2/CARD18/DEFA3/MEFV/TRAF5/CAMP/NLRP12/NLRP1/MAPK10/TXNIP/CASR	6.35430125065048
Environmental Information Processing	Signal transduction	hsa04010	MAPK signaling pathway	115/2187	300/9376	1.64340801707057	DUSP2/VEGFA/IL1B/MAP2K3/EREG/DUSP10/MRAS/IL1A/NFKB1/DUSP5/NFKB2/MAPKAPK2/MAP2K1/FLNA/DUSP16/RELB/NR4A1/AKT3/RASGRP3/RPS6KA3/HSPA6/GNA12/TAB2/GADD45A/NFATC1/GADD45G/DDIT3/MAP3K20/IRAK1/MAPK13/RAPGEF2/PAK1/IL1R1/ATF4/GADD45B/RAF1/MAP3K2/TNF/IL1RAP/PTPN7/DUSP8/FAS/PPP3CC/TGFB1/MYD88/KRAS/RELA/AREG/MAP3K21/PPM1A/HSPA8/PLA2G4C/NRAS/HSPA1B/MAPK8/PDGFB/PRKCG/RAP1B/MET/MAX/GRB2/EFNA2/CDC42/MAPK1/MAP3K12/TAOK3/PDGFA/BRAF/TRAF6/DUSP4/MAP4K4/MKNK2/ELK4/CASP3/RASGRP2/PPM1B/RPS6KA2/ATF2/HSPA1A/CACNA2D4/MYC/MAP3K4/CACNA1G/HSPA1L/FLT3/INSR/ELK1/RAP1A/FGF18/MAP2K4/RASGRF1/HSPB1/MAP3K5/CACNB2/CACNA1D/MAP3K14/TRAF2/PLA2G4A/PRKCB/MAP4K3/FLT4/SRF/RASGRP1/MAPK8IP1/TGFB2/DUSP1/PDGFD/CACNG2/NTRK1/MAPK10/JUND/CACNB1/EFNA1/IGF1R/FGFR1	6.24705946144165
Human Diseases	Infectious disease: viral	hsa05162	Measles	63/2187	136/9376	1.98595981602518	TNFAIP3/IL1B/TRAF3/MX1/MX2/BCL2/FCGR2B/NFKBIA/IL1A/NFKB1/PIK3CB/IFIH1/OAS2/AKT3/STAT1/BID/HSPA6/MSN/IRF7/EIF2AK2/TAB2/IL6/IRAK1/JAK1/TBK1/ADAR/OAS3/CYCS/STAT5A/PIK3R1/SLAMF1/FAS/EIF3H/IL2RG/NFKBIB/MYD88/CASP8/RELA/IFNAR2/IRF9/HSPA8/HSPA1B/IFNAR1/MAPK8/OAS1/STAT2/EIF2S1/TRAF6/TLR2/CASP3/HSPA1A/IL2RA/CD46/HSPA1L/STAT5B/GSK3B/BCL2L1/PIK3R3/STAT3/CCND3/CASP9/CCNE2/MAPK10	6.38805242470924
Organismal Systems	Immune system	hsa04625	C-type lectin receptor signaling pathway	52/2187	105/9376	2.12316066801664	IL1B/PTGS2/IRF1/MRAS/NFKBIA/SRC/NFKB1/ITPR1/PLK3/NFKB2/MAPKAPK2/MALT1/PIK3CB/RELB/CYLD/AKT3/STAT1/CLEC4E/NFATC1/IL6/BCL3/MAPK13/PAK1/LSP1/RAF1/MDM2/PIK3R1/BCL10/IL10/TNF/PLCG2/IL23A/PPP3CC/CASP1/KRAS/CASP8/RELA/RHOA/IRF9/NRAS/PTPN11/MAPK8/STAT2/MAPK1/PRKCD/EGR3/KSR1/CLEC7A/PIK3R3/CALM1/MAP3K14/MAPK10	6.38335552482147
Human Diseases	Infectious disease: viral	hsa05166	Human T-cell leukemia virus 1 infection	91/2187	224/9376	1.7416552354824	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/CDKN1A/HLA-DPA1/HLA-DMA/FOSL1/HLA-DRA/NFKBIA/HLA-DOA/HLA-A/HLA-B/NFKB1/NFKB2/HLA-F/MAP2K1/PIK3CB/IL15/RELB/AKT3/ETS2/HLA-DMB/ADCY3/HLA-E/HLA-DQB2/NFATC1/CREB5/MAD1L1/IL6/HLA-C/JAK1/IL1R1/ATF4/CSF2/STAT5A/PIK3R1/TNF/SMAD3/CREBBP/B2M/CD40/PPP3CC/IL2RG/TGFB1/EP300/KRAS/IL1R2/ICAM1/RELA/TLN1/CANX/PTTG1/NRAS/SMAD2/CDKN2B/MAPK8/ZFP36/CHEK1/MAPK1/KAT5/ELK4/HLA-G/ADCY9/ATF2/IL2RA/MYC/PTEN/IL15RA/ESPL1/ELK1/RANBP3/E2F3/SPI1/STAT5B/MAP2K4/CRTC3/BCL2L1/PIK3R3/ITGB2/KAT2B/CRTC1/MAP3K14/CCND3/SRF/CCNE2/TGFB2/CCNB2/MAPK10	6.19646296275824
Cellular Processes	Cell growth and death	hsa04218	Cellular senescence	68/2187	157/9376	1.85685536129823	CDKN1A/MAP2K3/MRAS/IL1A/HLA-A/HLA-B/NFKB1/ITPR1/MAPKAPK2/CAPN2/HLA-F/HIPK2/MAP2K1/PIK3CB/RASSF5/CXCL8/AKT3/HLA-E/GADD45A/NFATC1/GADD45G/IL6/NBN/FOXO1/RHEB/HLA-C/MAPK13/GADD45B/RAF1/PPID/MDM2/SERPINE1/PIK3R1/SIRT1/SMAD3/PPP3CC/TGFB1/HIPK4/KRAS/HUS1/LIN54/RELA/ZFP36L2/TRAF3IP2/SQSTM1/NRAS/SMAD2/CDKN2B/CHEK1/RAD9A/MAPK1/FOXO3/MCU/HLA-G/MYC/PTEN/E2F3/TRPM7/PIK3R3/CALM1/CACNA1D/CCND3/CCNE2/TRPV4/TGFB2/HIPK3/RAD9B/CCNB2	5.97160709088628
Cellular Processes	Transport and catabolism	hsa04145	Phagosome	67/2187	155/9376	1.85315574435447	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/OLR1/ITGA5/C3/HLA-DRA/FCGR2B/HLA-DOA/HLA-A/HLA-B/ATP6V1H/HLA-F/TUBB6/CTSS/MSR1/TUBB4B/HLA-DMB/ITGAV/RAB7A/DYNC1H1/THBS1/HLA-E/HLA-DQB2/HLA-C/TUBA1C/RAB5A/RAB7B/DYNC1LI1/TUBA4A/TAP1/ATP6V1A/SEC22B/ATP6V0D1/CANX/LAMP2/ATP6V1B2/TAP2/VAMP3/ATP6V1C1/HGS/M6PR/ATP6V1E1/STX18/ITGB3/TCIRG1/TLR2/TFRC/HLA-G/FCGR2A/ATP6V1F/NCF2/CTSL/CLEC7A/ITGB2/ITGAM/ATP6V0D2/NCF1/ATP6V1E2/MPO/SCARB1/THBS3	5.90719007384421
Genetic Information Processing	Folding, sorting and degradation	hsa04141	Protein processing in endoplasmic reticulum	73/2187	174/9376	1.79863246246104	ERN1/PPP1R15A/UBE2D1/BCL2/CAPN2/EIF2AK3/EDEM1/NFE2L2/DNAJB1/HSPA5/CUL1/HSPA6/DNAJC3/SEC24A/STT3B/DDIT3/HSP90AB1/ERO1B/ATF4/ERO1A/DNAJB11/NPLOC4/HSP90AA1/UBE2J1/HYOU1/HERPUD1/UFD1/UBQLN1/PDIA3/CRYAB/HSPH1/BAG1/CANX/DERL1/NGLY1/MAGT1/SSR3/SSR1/SEC24D/HSPA8/SAR1A/HSPA1B/UBE2D2/OS9/MAPK8/SEL1L/DNAJA1/SEC63/SELENOS/RAD23A/EIF2S1/SEL1L2/RAD23B/UBE2G1/SEC31A/SEC24C/DNAJC5B/HSPA1A/SVIP/UBE2D3/DNAJB2/HSPA1L/RNF185/DNAJC1/HSPA4L/MAP3K5/XBP1/TRAF2/FBXO6/SKP1/HSPBP1/ATF6/MAPK10	5.864841192279
Human Diseases	Cancer: specific types	hsa05210	Colorectal cancer	43/2187	87/9376	2.11893687358424	CDKN1A/EREG/BCL2/MAP2K1/PIK3CB/RALGDS/AKT3/RALA/GADD45A/GADD45G/GADD45B/CYCS/BCL2L11/RAF1/PMAIP1/TCF7/PIK3R1/SMAD3/TGFB1/KRAS/RHOA/AREG/NRAS/TCF7L2/SMAD2/MAPK8/CTNNB1/GRB2/MAPK1/DDB2/BRAF/MLH1/RPS6KB1/CASP3/RALB/AXIN1/MYC/APC2/GSK3B/PIK3R3/CASP9/TGFB2/MAPK10	5.78304429344772
Human Diseases	Infectious disease: bacterial	hsa05131	Shigellosis	96/2187	253/9376	1.62674517585951	IL1B/ITGA5/CD44/UBE2D1/BCL2/C3/TNIP1/NFKBIA/SRC/UBC/NFKB1/ITPR1/CAPN2/HK2/MALT1/PIK3CB/DIAPH1/CXCL8/ACTN1/AKT3/CUL1/IL18/ARHGEF2/TAB2/FOXO1/RIPK2/MAPK13/TBK1/FNBP1/IL1R1/MAP1LC3B/CSF2/CGAS/CYCS/RRAGD/PRKCE/RIPK1/UBE2N/PPID/MDM2/SEPTIN6/CAST/PIK3R1/BCL10/TNF/PLCG2/RPTOR/CASP1/NFKBIB/MYD88/HK1/RRAGC/RELA/RHOA/TLN1/SQSTM1/SEPTIN9/BECN1/UBE2D2/ACTR3/CYTH1/CALCOCO2/MAPK8/ATG16L1/ARF1/ATG12/CYTH3/CDC42/GSK3A/MAPK1/PRKCD/FOXO3/MYL9/TRAF6/TIFA/RPS6KB1/VCL/TAB3/UBE2D3/AKT1S1/HCLS1/HK3/U2AF1L4/GSK3B/BCL2L1/PIK3R3/MAP1LC3B2/TRAF2/WIPI1/TLR5/SKP1/TRAF5/ACTR3B/PLCD1/ARPC5/MAPK10	5.5738876535429
Human Diseases	Infectious disease: viral	hsa05160	Hepatitis C	66/2187	156/9376	1.81379480144912	CDKN1A/TRAF3/MX1/MX2/NFKBIA/NFKB1/MAP2K1/PIK3CB/OAS2/AKT3/CFLAR/STAT1/BID/TICAM1/IRF7/EIF2AK2/JAK1/TBK1/OAS3/CYCS/RIPK1/RAF1/PIK3R1/PPP2CA/RSAD2/TNF/YWHAG/YWHAQ/LDLR/FAS/KRAS/YWHAH/CASP8/RELA/IFNAR2/IRF9/PPP2R2D/PPP2R2A/NRAS/IFNAR1/YWHAZ/CTNNB1/OAS1/GRB2/STAT2/MAPK1/EIF2S1/RXRA/BRAF/TRAF6/CLDN1/CASP3/CLDN12/NR1H3/MYC/PPP2R1B/E2F3/CLDN14/GSK3B/PIK3R3/STAT3/CXCL10/TRAF2/CASP9/SCARB1/CLDN4	5.65311132275014
Cellular Processes	Transport and catabolism	hsa04142	Lysosome biogenesis	95/2187	250/9376	1.6291175125743	IGF2R/LITAF/PSAP/ATP6V1H/AP1S3/GM2A/CTSH/CTSS/ARL8B/RAB7A/IDS/ACP5/ARSG/CLN8/SLC36A4/CTSD/CTSA/SLC11A1/LAPTM5/BLOC1S2/NPC1/SLC17A5/RRAGD/PPT1/OSBP/GLA/CTSB/SLC2A6/GNS/LAMP3/SLC36A3/AP1G1/BLOC1S6/RPTOR/AP5B1/PLEKHM1/AP5Z1/HEXB/ATP6V1A/RRAGC/ATP6V0D1/DNASE2/TMEM175/VPS13A/LAMP2/ATP6V1B2/LIPA/OSBPL1A/AP3D1/GGA2/MANBA/AP3B1/GUSB/TPCN2/SLC15A3/TFEB/ATP6V1C1/M6PR/ATP6V1E1/GGA1/DMXL2/AP4S1/MCOLN2/CLCN7/TCIRG1/ARL8A/VAMP7/TFE3/GNPTAB/GNPTG/SLC11A2/ARSB/ABCA5/ATP6V1F/CD68/GALC/AGA/CLN3/HEXA/CTSZ/CTSL/GGA3/SLC15A4/AKT1S1/AP4B1/TPP1/CTSV/SORT1/SLC29A1/OSBPL2/ATP6V0D2/ATP6V1E2/GALNS/ASAH1/AP3B2	5.56080075827245
Human Diseases	Infectious disease: viral	hsa05170	Human immunodeficiency virus 1 infection	83/2187	214/9376	1.66277365400476	CXCR4/MAP2K3/BCL2/NFKBIA/HLA-A/HLA-B/NFKB1/ITPR1/PTK2B/HLA-F/AP1S3/MAP2K1/PIK3CB/AKT3/BID/CUL1/HLA-E/TAB2/NFATC1/IRAK1/HLA-C/MAPK13/TBK1/PAK1/CGAS/CYCS/RIPK1/RAF1/CCR5/PIK3R1/TNF/AP1G1/PLCG2/B2M/TAPBP/PDIA3/TAP1/FAS/PPP3CC/MYD88/KRAS/CASP8/RELA/APOBEC3A/GNB1/TAP2/NRAS/LIMK1/TNFRSF1B/ELOC/MAPK8/DDB1/DCAF1/PRKCG/WEE1/CHEK1/GNB4/MAPK1/CUL4A/GNGT2/TRAF6/SAMHD1/RPS6KB1/GNG4/TLR2/CASP3/HLA-G/TAPBPL/GNAI3/BCL2L1/GNAQ/PIK3R3/CALM1/GNG7/TRAF2/PRKCB/CASP9/GNG5/SKP1/TRAF5/GNB5/CCNB2/MAPK10	5.40944571944459
Organismal Systems	Nervous system	hsa04722	Neurotrophin signaling pathway	53/2187	120/9376	1.89349184575522	RAPGEF1/IRAK2/BCL2/NFKBIA/NFKB1/MAPKAPK2/MAP2K1/PIK3CB/AKT3/RPS6KA3/NFKBIE/IRAK1/PSEN1/RIPK2/MAPK13/ATF4/RAF1/IRAK3/PIK3R1/PLCG2/SH2B3/NFKBIB/KRAS/RELA/RHOA/ZNF274/PRDM4/NRAS/SHC3/PTPN11/MAPK8/PDPK1/RAP1B/GRB2/CDC42/MAPK1/PRKCD/FOXO3/BRAF/ARHGDIA/TRAF6/RPS6KA2/RAP1A/GSK3B/MAP3K5/PIK3R3/SORT1/NTRK3/CALM1/CAMK2D/ARHGDIB/NTRK1/MAPK10	5.43307038520473
Organismal Systems	Immune system	hsa04062	Chemokine signaling pathway	76/2187	193/9376	1.6882046762428	CXCR4/CXCL3/CXCL2/TIAM1/PIK3R5/FGR/CCL20/NFKBIA/SRC/NFKB1/PTK2B/MAP2K1/PIK3CB/CXCL8/AKT3/CCR7/CCL21/STAT1/CXCL1/ADCY3/PAK1/CXCL16/CCL18/RAF1/CCR5/PIK3R1/PLCG2/NFKBIB/KRAS/RELA/RHOA/GRK6/GNB1/NRAS/PIK3R6/SHC3/CCL14/RAP1B/GRB2/CDC42/GSK3A/STAT2/GNB4/MAPK1/PRKCD/FOXO3/BRAF/GNGT2/GNG4/CXCL5/RASGRP2/PREX1/ADCY9/GNAI3/CXCL12/RAP1A/STAT5B/CCR3/CXCL9/GSK3B/GNAQ/PIK3R3/STAT3/VAV2/GNG7/CXCL10/NCF1/PRKCB/GNG5/GNB5/CCL3/GRK7/CXCL11/CCL3L1/CCR2/GRK4	5.32819081465873
Organismal Systems	Endocrine system	hsa04919	Thyroid hormone signaling pathway	53/2187	122/9376	1.86245099582481	SRC/MAP2K1/PIK3CB/AKT3/ITGAV/STAT1/NOTCH2/MED13/FOXO1/RHEB/SLC9A1/ATP1A1/ATP2A2/RAF1/MDM2/PIK3R1/PLCG2/CREBBP/EP300/KRAS/PFKP/SIN3A/NOTCH1/NRAS/PDPK1/PRKCG/CTNNB1/THRB/MAPK1/ITGB3/ATP2A3/RXRA/MED17/ESR1/MYC/ATP1B3/MED27/GSK3B/PIK3R3/KAT2B/NCOA3/ATP2A1/PRKCB/CASP9/SLC16A10/PLCD1/PLN/MED12L/ATP1B2/HIF1A/NOTCH4/FXYD2/MED13L	5.288413237513
Environmental Information Processing	Signal transduction	hsa04066	HIF-1 signaling pathway	49/2187	110/9376	1.90973105541007	CDKN1A/VEGFA/BCL2/NFKB1/PFKFB3/HK2/IL6R/MAP2K1/PIK3CB/EIF4E/AKT3/IL6/SERPINE1/PIK3R1/PLCG2/CREBBP/LDHA/EP300/HK1/PFKP/TF/RELA/EGLN1/HMOX1/IFNGR2/ENO1/ELOC/PRKCG/MAPK1/PGK1/RPS6KB1/MKNK2/TFRC/LDHC/INSR/EGLN3/ALDOB/EDN1/ALDOC/HK3/IFNGR1/PDK1/PIK3R3/STAT3/ENO3/CAMK2D/PRKCB/HIF1A/IGF1R	5.2934522883862
Organismal Systems	Immune system	hsa04658	Th1 and Th2 cell differentiation	43/2187	93/9376	1.98223126883687	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/HLA-DRA/STAT4/NFKBIA/HLA-DOA/NFKB1/HLA-DMB/RUNX3/STAT1/NFKBIE/HLA-DQB2/NFATC1/NOTCH2/JAK1/MAPK13/STAT5A/PPP3CC/IL2RG/IL4R/NFKBIB/RELA/MAML1/NOTCH1/IFNGR2/MAPK8/MAPK1/JAG1/IL2RA/DLL1/STAT6/STAT5B/LAT/IL12RB1/IFNGR1/MAPK10/MAML3	5.25033291916671
Human Diseases	Cancer: specific types	hsa05215	Prostate cancer	47/2187	106/9376	1.90090673016366	CDKN1A/BCL2/NFKBIA/NFKB1/MAP2K1/PIK3CB/AKT3/PLAU/CREB5/HSP90AB1/FOXO1/MMP9/ATF4/RAF1/MDM2/TCF7/PIK3R1/HSP90AA1/CREBBP/EP300/KRAS/IL1R2/RELA/NRAS/TCF7L2/PDGFB/PDPK1/CTNNB1/GRB2/MAPK1/PDGFA/BRAF/ZEB1/PTEN/E2F3/GSK3B/SLC19A1/ERG/PIK3R3/SPINT1/CASP9/CCNE2/AR/PDGFD/NKX3-1/IGF1R/FGFR1	5.14480222944712
Organismal Systems	Immune system	hsa04657	IL-17 signaling pathway	43/2187	94/9376	1.96114370214712	TNFAIP3/CXCL3/IL1B/MAPK6/CXCL2/TRAF3/PTGS2/FOSL1/CCL20/NFKBIA/NFKB1/CXCL8/CXCL1/TAB2/IL6/HSP90AB1/MAPK13/TBK1/MMP9/CSF2/CSF3/TNF/HSP90AA1/CASP8/RELA/TRAF3IP2/S100A8/MAPK8/MAPK1/TRAF6/CXCL5/CASP3/TAB3/CEBPB/USP25/TRAF4/GSK3B/FOSB/CXCL10/TRAF2/TRAF5/MAPK10/JUND	5.16543923844617
Human Diseases	Infectious disease: viral	hsa05165	Human papillomavirus infection	115/2187	333/9376	1.48054776312664	CDKN1A/VEGFA/ITGA5/TRAF3/PTGS2/MX1/IRF1/MX2/ITGB8/HLA-A/HLA-B/NFKB1/ATP6V1H/OASL/HLA-F/HES4/MAP2K1/PIK3CB/AKT3/ITGAV/STAT1/HES1/TICAM1/THBS1/HLA-E/EIF2AK2/NOTCH2/CREB5/FOXO1/PSEN1/RHEB/HLA-C/JAK1/TBK1/PTGER4/LFNG/RAF1/MDM2/ITGA4/TCF7/ISG15/PIK3R1/PPP2CA/FN1/TNF/CREBBP/FAS/ATP6V1A/EP300/LAMB3/KRAS/CASP8/RELA/ATP6V0D1/IFNAR2/MAML1/ATP6V1B2/IRF9/NOTCH1/PPP2R2D/PPP2R2A/NRAS/VWF/TCF7L2/WNT2B/TNC/IFNAR1/ATP6V1C1/CTNNB1/ATP6V1E1/GRB2/PPP2R3A/PPP2R3C/UBR4/CDC42/STAT2/MAPK1/ITGB3/JAG1/CHD4/RPS6KB1/TCIRG1/CASP3/HLA-G/AXIN1/ATP6V1F/PTEN/UBE3A/PPP2R1B/PRKCI/PPP2R5A/APC2/NFX1/GSK3B/PIK3R3/CSNK1A1/ATP6V0D2/ITGB7/CCND3/ATP6V1E2/WNT5A/ITGA10/ITGB4/CCNE2/LAMA3/RELN/WNT5B/HEY1/COL9A2/THBS3/MAML3/WNT9A/NOTCH4/FZD8/LAMB1	4.92468208042682
Human Diseases	Immune disease	hsa05330	Allograft rejection	23/2187	39/9376	2.52832002626241	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/HLA-DRA/HLA-DOA/HLA-A/HLA-B/HLA-F/CD80/HLA-DMB/HLA-E/HLA-DQB2/HLA-C/IL10/TNF/CD40/FAS/HLA-G	5.27495447595614
Human Diseases	Cancer: overview	hsa05205	Proteoglycans in cancer	77/2187	204/9376	1.61818947972422	CDKN1A/VEGFA/ITGA5/CD44/TIAM1/MRAS/SRC/PLAUR/ITPR1/MAP2K1/PIK3CB/FLNA/SDC4/AKT3/PLAU/ITGAV/SDC2/EZR/MSN/THBS1/RDX/SLC9A1/MAPK13/MMP9/PAK1/HPSE/RAF1/MDM2/PIK3R1/FN1/TNF/HBEGF/PLCG2/FAS/TGFB1/KRAS/RHOA/DDX5/NRAS/WNT2B/SMAD2/PTPN11/PDPK1/PRKCG/MET/CTNNB1/EIF4B/GRB2/CDC42/MAPK1/ITGB3/BRAF/RPS6KB1/TLR2/CASP3/CBL/ESR1/MYC/IQGAP1/ELK1/CTSL/HCLS1/PPP1R12A/PIK3R3/STAT3/CAMK2D/VAV2/PRKCB/WNT5A/TGFB2/TIMP3/WNT5B/WNT9A/HIF1A/FZD8/IGF1R/FGFR1	4.92357387507046
Cellular Processes	Cell growth and death	hsa04216	Ferroptosis	24/2187	42/9376	2.44980077078842	ACSL5/SAT1/FTH1/SLC7A11/GCLC/ACSL3/MAP1LC3B/SLC3A2/ACSL1/ACSL4/SLC39A8/GCLM/PRNP/TF/HMOX1/TFRC/SLC11A2/PCBP1/LPCAT3/STEAP3/CP/SLC39A14/MAP1LC3B2/FTL	5.19367609381127
Organismal Systems	Immune system	hsa04672	Intestinal immune network for IgA production	27/2187	50/9376	2.31506172839506	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/CXCR4/HLA-DQA2/HLA-DPA1/HLA-DMA/HLA-DRA/HLA-DOA/CD80/IL15/HLA-DMB/HLA-DQB2/IL6/TNFSF13B/TNFSF13/ITGA4/IL10/CD40/TGFB1/ICOSLG/IL15RA/CXCL12/ITGB7/MAP3K14	5.14232147619231
Human Diseases	Immune disease	hsa05332	Graft-versus-host disease	25/2187	45/9376	2.38175074937764	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/IL1B/HLA-DMA/HLA-DRA/HLA-DOA/IL1A/HLA-A/HLA-B/HLA-F/CD80/HLA-DMB/HLA-E/HLA-DQB2/IL6/HLA-C/TNF/FAS/HLA-G/KLRD1	5.12445470635906
Cellular Processes	Transport and catabolism	hsa04144	Endocytosis	90/2187	250/9376	1.54337448559671	CXCR4/IGF2R/SRC/HLA-A/HLA-B/ARFGAP3/HLA-F/AGAP3/EHD1/CHMP4B/CHMP1B/RAB7A/HSPA6/HLA-E/HLA-C/CHMP2B/RAB5A/SPART/NEDD4L/MDM2/CCR5/RAB8A/ZFYVE16/PSD/LDLR/SMAD3/WASHC2A/IL2RG/RHOA/RAB31/SNX32/RAB22A/RAB35/SMURF1/IST1/WASHC2C/VPS4B/SMAP1/GRK6/HSPA8/SMURF2/WIPF2/SMAP2/HSPA1B/ARFGEF2/ACTR3/SMAD2/CYTH1/PDCD6IP/KIF5B/HGS/ARF1/CYTH3/PIP5K1A/CDC42/PIP5K1C/DNAJC6/CHMP1A/RAB11FIP1/VPS37C/STAM/RAB10/TRAF6/SNX1/PSD4/TFRC/CBL/HLA-G/SH3KBP1/ARF4/IQSEC2/IQSEC1/USP8/HSPA1A/IL2RA/HSPA1L/DNM2/PRKCI/GBF1/ASAP1/RAB11A/ARFGEF1/ACTR3B/RAB11FIP3/DNM3/AGAP2/ARPC5/GRK7/GRK4/IGF1R	4.80291390898963
Cellular Processes	Cellular community - eukaryotes	hsa04510	Focal adhesion	76/2187	203/9376	1.60504188430966	VEGFA/RAPGEF1/ITGA5/BCL2/SRC/ITGB8/CAPN2/MAP2K1/PIK3CB/DIAPH1/BIRC3/FLNA/ACTN1/AKT3/ITGAV/BIRC2/THBS1/PAK1/EMP1/RAF1/ITGA4/PIK3R1/FYN/FN1/PARVB/LAMB3/RHOA/TLN1/ZYX/PARVG/EMP2/VWF/SHC3/TNC/MAPK8/PDGFB/PDPK1/PRKCG/RAP1B/MET/CTNNB1/PIP5K1A/GRB2/CDC42/PIP5K1C/VASP/MAPK1/ITGB3/PDGFA/BRAF/MYL9/VCL/PTEN/ELK1/RAP1A/GSK3B/RASGRF1/PPP1R12A/PIK3R3/MYLK3/VAV2/ITGB7/CCND3/PRKCB/ITGA10/ITGB4/FLT4/FLNB/LAMA3/RELN/PDGFD/MAPK10/COL9A2/THBS3/IGF1R/LAMB1	4.8067723027844
Organismal Systems	Immune system	hsa04640	Hematopoietic cell lineage	44/2187	100/9376	1.88634659350709	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/IL1B/HLA-DMA/ITGA5/CD44/IL3RA/HLA-DRA/HLA-DOA/IL1A/IL6R/CD22/HLA-DMB/CSF2RA/CSF3R/HLA-DQB2/IL6/ANPEP/IL1R1/CSF2/CSF3/ITGA4/TNF/CD55/IL7R/IL4R/CD38/IL1R2/CD37/ITGB3/TFRC/CD1D/IL7/IL2RA/FLT3/CD1C/ITGAM/MME/CD5	4.91472246103672
Human Diseases	Cancer: specific types	hsa05213	Endometrial cancer	30/2187	59/9376	2.17990746553207	CDKN1A/MAP2K1/PIK3CB/AKT3/GADD45A/GADD45G/GADD45B/RAF1/TCF7/PIK3R1/KRAS/CTNNA1/NRAS/TCF7L2/PDPK1/CTNNB1/GRB2/MAPK1/DDB2/FOXO3/BRAF/MLH1/AXIN1/MYC/PTEN/ELK1/APC2/GSK3B/PIK3R3/CASP9	5.01431594770629
Organismal Systems	Immune system	hsa04662	B cell receptor signaling pathway	41/2187	91/9376	1.9315736846601	FCGR2B/NFKBIA/NFKB1/CD72/MALT1/MAP2K1/PIK3CB/CD22/AKT3/RASGRP3/NFKBIE/NFATC1/LILRB2/RAF1/PIK3R1/BCL10/LILRB4/LILRB1/PLCG2/PPP3CC/NFKBIB/KRAS/RELA/LILRA6/NRAS/BTK/DAPP1/GRB2/MAPK1/INPPL1/CARD11/IFITM1/LILRA5/LILRA2/LILRB3/GSK3B/LILRA1/PIK3R3/VAV2/LILRA4/PRKCB	4.92518719871589
Cellular Processes	Transport and catabolism	hsa04148	Efferocytosis	62/2187	157/9376	1.69301518236015	DUSP2/GPR132/PTGS2/SPHK1/DUSP5/AXL/SGK1/MAPKAPK2/MAP2K1/DUSP16/ITGAV/RAB7A/THBS1/NFATC1/PPARD/MAPK13/SLC16A1/PTGER4/ADAM17/ATP2A2/PTGER2/RAB5A/RAB7B/ABCA1/SIRT1/IL10/SIGLEC10/ANO6/DUSP8/CASP1/TGFB1/HAVCR1/SIRPA/PLA2G6/LIPA/ATP11B/PPARG/MFGE8/HAVCR2/PANX1/PTPN11/CPT1A/MAPK1/ITGB3/ATP2A3/RXRA/DUSP4/CASP3/NR1H3/CEBPB/ATP11C/ANO5/ATP8A1/P2RY6/ADGRB1/XKR6/CAMK2D/ATP2A1/SIRPB1/ALOX5/CPT1B/HIF1A	4.82977006854877
Human Diseases	Infectious disease: bacterial	hsa05130	Pathogenic Escherichia coli infection	75/2187	200/9376	1.6076817558299	IL1B/NFKBIA/SRC/NFKB1/TUBB6/CXCL8/TUBB4B/SEC24A/IL18/EZR/GNA12/ARHGEF2/TAB2/MYH9/IL6/MYO1G/IRAK1/ABI1/MAPK13/PAK1/IL1R1/TUBA1C/MYH11/CYCS/RIPK1/FYN/TNF/GNA13/NCL/TUBA4A/FAS/CASP1/NFKBIB/MYD88/CASP8/RELA/RHOA/TNFRSF10A/TNFRSF10B/SEC24D/WIPF2/ACTR3/CYTH1/PTPN11/MAPK8/ARF1/CYTH3/CDC42/MAPK1/TRAF6/CLDN1/CASP3/SEC24C/TAB3/TMED10/FCGR2A/CLDN12/MYO5C/HCLS1/CLDN14/CYFIP2/RAB1A/MYO1D/TRAF2/TMBIM6/TLR5/CASP9/ACTR3B/BAIAP2L1/MYO1E/ARPC5/LPAR1/LPAR2/MAPK10/CLDN4	4.7911556634155
Environmental Information Processing	Signal transduction	hsa04071	Sphingolipid signaling pathway	52/2187	125/9376	1.78345496113397	BCL2/SPHK1/SGMS2/NFKB1/SGPP2/MAP2K1/PIK3CB/NSMAF/AKT3/BID/GNA12/CTSD/MAPK13/PRKCE/RAF1/PIK3R1/FYN/PPP2CA/TNF/GNA13/SGPL1/KRAS/RELA/RHOA/PPP2R2D/PPP2R2A/NRAS/MAPK8/PDPK1/PRKCG/ORMDL2/PPP2R3A/PPP2R3C/MAPK1/CERS5/GNAI3/PTEN/PPP2R1B/PPP2R5A/GAB2/ADORA3/MAP3K5/GNAQ/PIK3R3/TRAF2/PRKCB/ACER2/SMPD2/ASAH1/MAPK10/S1PR4/CERS6	4.86351756782787
Human Diseases	Cancer: overview	hsa05202	Transcriptional misregulation in cancer	75/2187	201/9376	1.59968333913423	CDK14/CDKN1A/TRAF1/DOT1L/NFKB1/CXCL8/BIRC3/PLAU/RARA/RUNX2/REL/ID2/BIRC2/GADD45A/GADD45G/DDIT3/IL6/FOXO1/BCL2A1/MMP9/CSF2/GADD45B/FUS/MDM2/EWSR1/BCL6/HMGA2/KDM6A/PBX3/CD40/IL1R2/RELA/SIN3A/ETV6/DDX5/PRCC/PPARG/ZBTB17/ATF1/CCNT2/MET/PAX8/MAX/DDB2/PDGFA/RXRA/ELK4/JUP/TFE3/SUPT3H/NFKBIZ/ZEB1/CEBPB/MYC/SS18L1/FLT3/SPI1/ZBTB16/BCL2L1/ERG/ETV7/NUPR1/ITGAM/SPINT1/AFF1/SP1/ITGB7/ARNT2/DEFA3/MPO/SLC45A3/JMJD1C/NTRK1/CEBPE/IGF1R	4.74015740347447
Environmental Information Processing	Signal transduction	hsa04150	mTOR signaling pathway	62/2187	158/9376	1.68229989639585	SLC7A5/FNIP2/ATP6V1H/SGK1/MAP2K1/PIK3CB/EIF4E/AKT3/RPS6KA3/TBC1D7/DDIT4/RHEB/SLC3A2/RRAGD/RAF1/PIK3R1/TNF/LPIN1/RPTOR/ATP6V1A/CLIP1/MAPKAP1/RRAGC/KRAS/RHOA/SESN2/ATP6V1B2/NRAS/WNT2B/ATP6V1C1/PDPK1/PRKCG/ATP6V1E1/LPIN2/EIF4B/GRB2/MAPK1/BRAF/RPS6KB1/FNIP1/RPS6KA2/ATP6V1F/WDR59/GRB10/PTEN/INSR/DEPDC5/AKT1S1/GSK3B/PIK3R3/CAB39L/PRKCB/ATP6V1E2/WNT5A/PRR5L/ULK1/CAB39/RNF152/WNT5B/WNT9A/FZD8/IGF1R	4.7704712717683
Environmental Information Processing	Signal transduction	hsa04630	JAK-STAT signaling pathway	65/2187	168/9376	1.658719271888	CDKN1A/IL3RA/BCL2/STAT4/IL6R/PIK3CB/IL15/AKT3/CSF2RA/CSF3R/STAT1/CLCF1/IL6/OSM/JAK1/CSF2/CSF3/STAT5A/RAF1/MCL1/PIK3R1/IL10/SOCS1/CREBBP/IL7R/IL23A/IL2RG/IL4R/EP300/IFNAR2/IL19/IRF9/IFNGR2/IL10RA/IL13RA1/CRLF2/CSH2/PTPN11/IFNAR1/PDGFB/SOCS6/GRB2/STAT2/PDGFA/STAM/PTPN2/TSLP/IL7/IL2RA/MYC/IL15RA/SOCS4/STAT6/STAT5B/LIF/IL12RB1/BCL2L1/IFNGR1/PIK3R3/STAT3/CCND3/IFNLR1/IL20RB/IL27RA/IL27	4.75169047621202
Human Diseases	Cancer: specific types	hsa05212	Pancreatic cancer	36/2187	77/9376	2.00438244882689	CDKN1A/VEGFA/NFKB1/MAP2K1/PIK3CB/RALGDS/AKT3/STAT1/RALA/GADD45A/GADD45G/JAK1/GADD45B/RAF1/PIK3R1/SMAD3/TGFB1/KRAS/RELA/BRCA2/SMAD2/MAPK8/CDC42/MAPK1/DDB2/BRAF/RPS6KB1/RALB/E2F3/BCL2L1/PIK3R3/STAT3/CASP9/TGFB2/MAPK10/RAD51	4.88092508167085
Human Diseases	Cancer: overview	hsa05203	Viral carcinogenesis	76/2187	205/9376	1.58938293909688	CDKN1A/TRAF3/TRAF1/C3/NFKBIA/SRC/HLA-A/HLA-B/NFKB1/NFKB2/MAPKAPK2/HLA-F/PIK3CB/ACTN1/REL/HLA-E/IRF7/EIF2AK2/CREB5/MAD1L1/GTF2A1/HLA-C/JAK1/ATF4/USP7/STAT5A/PMAIP1/MDM2/CCR5/PIK3R1/YWHAG/YWHAQ/CREBBP/EP300/KRAS/YWHAH/CASP8/RELA/RHOA/ATP6V0D1/IRF9/SND1/SNW1/NRAS/YWHAZ/CDKN2B/DDB1/HDAC4/GTF2H1/CHEK1/GRB2/UBR4/CDC42/MAPK1/CHD4/CASP3/HLA-G/ATF2/UBE3A/EGR3/GTF2B/STAT5B/CCR3/PIK3R3/SP100/STAT3/GSN/KAT2B/ATP6V0D2/CCND3/TRAF2/DDX3X/TRAF5/SRF/CCNE2/HDAC6	4.70589173939074
Cellular Processes	Transport and catabolism	hsa04137	Mitophagy - animal	45/2187	105/9376	1.83735057809132	MRAS/SRC/UBC/EIF2AK3/RAB7A/GABARAPL1/TBK1/MAP1LC3B/ATF4/RAB5A/RAB7B/BCL2L13/SIAH1/KRAS/RELA/HUWE1/RABGEF1/SMURF1/SQSTM1/ARIH1/SMURF2/NRAS/BECN1/TFEB/CALCOCO2/MAPK8/EIF2S1/FOXO3/TFE3/MFN1/USP8/TBC1D15/TOMM70/TAX1BP1/BCL2L1/BNIP3L/MAP1LC3B2/TOMM40L/SP1/USP15/TRAF2/TBC1D17/ULK1/MAPK10/HIF1A	4.75898648437403
Human Diseases	Endocrine and metabolic disease	hsa04940	Type I diabetes mellitus	24/2187	44/9376	2.33844619029804	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/IL1B/HLA-DMA/HLA-DRA/HLA-DOA/IL1A/HLA-A/HLA-B/HLA-F/CD80/HLA-DMB/HLA-E/HLA-DQB2/HLA-C/TNF/FAS/HSPD1/HLA-G	4.90812570275382
Human Diseases	Infectious disease: bacterial	hsa05132	Salmonella infection	88/2187	248/9376	1.5212472528283	IL1B/MAP2K3/BCL2/NFKBIA/NFKB1/TUBB6/MAP2K1/ARL8B/PIK3CB/CXCL8/BIRC3/FLNA/AKT3/TUBB4B/RAB7A/RALA/ANXA2/IL18/DYNC1H1/AHNAK/BIRC2/SNX9/TAB2/ACBD3/IL6/HSP90AB1/RHOH/IRAK1/RIPK2/ABI1/MAPK13/PLEKHM2/PAK1/TXN/TUBA1C/RAB5A/RAB7B/CYCS/RIPK1/RAF1/DYNC1LI1/KPNA4/TCF7/TNF/HSP90AA1/PLEKHM1/TUBA4A/CASP1/MYD88/CASP8/RELA/RHOA/TNFRSF10A/TNFRSF10B/RHOB/S100A10/TCF7L2/ACTR3/CYTH1/KIF5B/MAPK8/M6PR/ACTR1B/CTNNB1/ARF1/CYTH3/CDC42/MAPK1/MYL9/TRAF6/ARL8A/TLR2/CASP3/MLKL/TAB3/FHOD1/MYC/DNM2/MAP2K4/CYFIP2/RHOJ/TRAF2/TLR5/SKP1/ACTR3B/ARPC5/FYCO1/MAPK10	4.58836112685403
Organismal Systems	Immune system	hsa04620	Toll-like receptor signaling pathway	46/2187	109/9376	1.80925653255475	IL1B/MAP2K3/TRAF3/NFKBIA/NFKB1/MAP2K1/PIK3CB/CD80/CXCL8/AKT3/STAT1/TICAM1/IRF7/TAB2/IL6/IRAK1/JAK1/MAPK13/TBK1/RIPK1/PIK3R1/TNF/CD40/MYD88/CASP8/RELA/IFNAR2/IRF9/TLR1/IFNAR1/MAPK8/STAT2/MAPK1/TRAF6/TLR2/TICAM2/MAP2K4/CXCL9/PIK3R3/IRF5/CXCL10/TLR5/CCL3/MAPK10/CXCL11/CCL3L1	4.68711564750325
Human Diseases	Cancer: specific types	hsa05211	Renal cell carcinoma	33/2187	70/9376	2.02108563590045	CDKN1A/VEGFA/RAPGEF1/MAP2K1/PIK3CB/AKT3/PAK1/RAF1/PIK3R1/CREBBP/TGFB1/EP300/FH/KRAS/EGLN1/PRCC/NRAS/PTPN11/ELOC/PDGFB/RAP1B/MET/GRB2/CDC42/MAPK1/BRAF/TFE3/RAP1A/EGLN3/PIK3R3/ARNT2/TGFB2/HIF1A	4.72939350523854
Human Diseases	Cardiovascular disease	hsa05416	Viral myocarditis	33/2187	70/9376	2.02108563590045	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/HLA-DRA/HLA-DOA/HLA-A/HLA-B/HLA-F/SNTB1/ABL2/CD80/HLA-DMB/BID/HLA-E/HLA-DQB2/HLA-C/CYCS/FYN/CD55/CD40/EIF4G2/CASP8/ICAM1/EIF4G1/CASP3/HLA-G/ITGB2/CASP9	4.72939350523854
Human Diseases	Cancer: specific types	hsa05221	Acute myeloid leukemia	32/2187	68/9376	2.01748298770811	NFKB1/MAP2K1/PIK3CB/AKT3/RARA/BCL2A1/PPARD/CSF2/STAT5A/RAF1/TCF7/PIK3R1/KRAS/RELA/NRAS/TCF7L2/GRB2/MAPK1/PIM2/BRAF/RPS6KB1/JUP/MYC/FLT3/SPI1/STAT5B/ZBTB16/PIK3R3/STAT3/ITGAM/MPO/CEBPE	4.64439569171562
Human Diseases	Cancer: specific types	hsa05222	Small cell lung cancer	40/2187	93/9376	1.8439360640343	CDKN1A/TRAF3/PTGS2/TRAF1/BCL2/NFKBIA/NFKB1/PIK3CB/BIRC3/AKT3/ITGAV/BIRC2/GADD45A/GADD45G/CKS2/GADD45B/CYCS/PIK3R1/FN1/LAMB3/RELA/ZBTB17/CDKN2B/MAX/DDB2/RXRA/TRAF6/CASP3/MYC/PTEN/E2F3/TRAF4/BCL2L1/PIK3R3/TRAF2/CASP9/TRAF5/CCNE2/LAMA3/LAMB1	4.51110185477831
Cellular Processes	Cell growth and death	hsa04115	p53 signaling pathway	34/2187	75/9376	1.94350861149215	CDKN1A/BCL2/ZNF385A/BID/THBS1/GADD45A/GADD45G/CD82/GADD45B/CYCS/PMAIP1/MDM2/SERPINE1/SIAH1/FAS/CASP8/TNFRSF10A/SESN2/TNFRSF10B/CHEK1/DDB2/CASP3/PPM1D/PTEN/STEAP3/BCL2L1/AIFM2/ADGRB1/PPP1R13L/CCND3/CASP9/CCNE2/COP1/CCNB2	4.52467578958808
Human Diseases	Infectious disease: parasitic	hsa05142	Chagas disease	43/2187	103/9376	1.78978163108572	IL1B/C3/NFKBIA/NFKB1/PIK3CB/CXCL8/AKT3/CFLAR/TICAM1/IL6/IRAK1/GNAL/MAPK13/SERPINE1/PIK3R1/PPP2CA/IL10/TNF/FAS/TGFB1/MYD88/CASP8/RELA/PPP2R2D/PPP2R2A/IFNGR2/GNA15/SMAD2/MAPK8/MAPK1/TRAF6/TLR2/GNAI3/PPP2R1B/MAP2K4/IFNGR1/GNAQ/PIK3R3/ACE/TGFB2/CCL3/MAPK10/CCL3L1	4.44519993142302
Environmental Information Processing	Signal transduction	hsa04068	FoxO signaling pathway	52/2187	133/9376	1.67617947474997	CDKN1A/SOD2/PLK3/PRKAG2/SGK1/MAP2K1/PIK3CB/AKT3/GABARAPL1/GADD45A/GADD45G/IL6/PLK2/FOXO1/MAPK13/GADD45B/USP7/BCL2L11/HOMER1/RAF1/IRS2/MDM2/PIK3R1/BCL6/SIRT1/IL10/SMAD3/CREBBP/IL7R/TGFB1/EP300/KRAS/NRAS/CDKN2B/MAPK8/PDPK1/ATG12/FBXO32/GRB2/MAPK1/FOXO3/BRAF/PTEN/INSR/PIK3R3/STAT3/TGFB2/AGAP2/CCNB2/MAPK10/S1PR4/IGF1R	4.33168747749177
Human Diseases	Endocrine and metabolic disease	hsa04933	AGE-RAGE signaling pathway in diabetic complications	42/2187	101/9376	1.78277580844504	VEGFA/IL1B/BCL2/IL1A/NFKB1/PIK3CB/DIAPH1/CXCL8/AKT3/THBD/STAT1/NFATC1/IL6/FOXO1/MAPK13/STAT5A/PRKCE/SERPINE1/PIK3R1/FN1/TNF/PLCG2/SMAD3/TGFB1/KRAS/ICAM1/RELA/NRAS/SMAD2/MAPK8/CDC42/MAPK1/PRKCD/CASP3/STAT5B/EDN1/PIK3R3/STAT3/PRKCB/PLCD1/TGFB2/MAPK10	4.36231388054812
Human Diseases	Drug resistance: antineoplastic	hsa01521	EGFR tyrosine kinase inhibitor resistance	35/2187	80/9376	1.87562871513489	VEGFA/BCL2/SRC/AXL/IL6R/MAP2K1/PIK3CB/EIF4E/AKT3/IL6/JAK1/BCL2L11/RAF1/PIK3R1/PLCG2/KRAS/NRAS/SHC3/PDGFB/PRKCG/MET/GRB2/MAPK1/FOXO3/PDGFA/BRAF/RPS6KB1/PTEN/GSK3B/BCL2L1/PIK3R3/STAT3/PRKCB/PDGFD/IGF1R	4.33803167875171
Human Diseases	Cancer: specific types	hsa05220	Chronic myeloid leukemia	34/2187	77/9376	1.89302786833651	CDKN1A/NFKBIA/NFKB1/MAP2K1/PIK3CB/AKT3/GADD45A/GADD45G/CTBP2/GADD45B/STAT5A/RAF1/MDM2/PIK3R1/SMAD3/TGFB1/KRAS/RELA/NRAS/SHC3/PTPN11/GRB2/MAPK1/DDB2/BRAF/CBL/MYC/BCR/E2F3/STAT5B/GAB2/BCL2L1/PIK3R3/TGFB2	4.33978324321154
Human Diseases	Infectious disease: bacterial	hsa05120	Epithelial cell signaling in Helicobacter pylori infection	32/2187	71/9376	1.93223722766411	CXCL3/CXCL2/NFKBIA/SRC/NFKB1/ATP6V1H/CXCL8/CXCL1/MAPK13/ADAM17/PAK1/HBEGF/PLCG2/ATP6V1A/RELA/ATP6V0D1/ATP6V1B2/F11R/PTPN11/MAPK8/ATP6V1C1/MET/ATP6V1E1/CDC42/TCIRG1/CASP3/ATP6V1F/MAP2K4/ATP6V0D2/MAP3K14/ATP6V1E2/MAPK10	4.34883785520095
Human Diseases	Infectious disease: bacterial	hsa05135	Yersinia infection	53/2187	138/9376	1.6465146484828	IL1B/ITGA5/MAP2K3/NFKBIA/SRC/NFKB1/PTK2B/MAP2K1/PIK3CB/CXCL8/AKT3/RPS6KA3/TICAM1/IL18/TAB2/NFATC1/IL6/IRAK1/MAPK13/TBK1/LCP2/ITGA4/PIK3R1/IL10/FN1/TNF/CASP1/MYD88/RELA/RHOA/WIPF2/LIMK1/ACTR3/MAPK8/PIP5K1A/CDC42/PIP5K1C/ARHGEF7/MAPK1/TRAF6/FCGR2A/RPS6KA2/MAP2K4/LAT/GSK3B/GNAQ/PIK3R3/VAV2/TRAF2/MEFV/ACTR3B/ARPC5/MAPK10	4.21992489482571
Human Diseases	Cancer: specific types	hsa05216	Thyroid cancer	20/2187	37/9376	2.31737910750256	CDKN1A/MAP2K1/GADD45A/GADD45G/GADD45B/TCF7/KRAS/PPARG/NRAS/TCF7L2/CCDC6/PAX8/CTNNB1/MAPK1/DDB2/RXRA/BRAF/MYC/NTRK1/TPM3	4.42830202823277
Environmental Information Processing	Signal transduction	hsa04151	PI3K-Akt signaling pathway	116/2187	362/9376	1.37378330516588	CDKN1A/VEGFA/ITGA5/EREG/PIK3R5/IL3RA/BCL2/ITGB8/NFKB1/SGK1/IL6R/MAP2K1/PIK3CB/EIF4E/NR4A1/AKT3/ITGAV/CSF3R/THBS1/CREB5/IL6/HSP90AB1/DDIT4/OSM/RHEB/JAK1/ATF4/PHLPP1/CSF3/BCL2L11/RAF1/MCL1/MDM2/ITGA4/PIK3R1/PPP2CA/FN1/HSP90AA1/YWHAG/YWHAQ/RPTOR/IL7R/IL2RG/IL4R/LAMB3/KRAS/YWHAH/RELA/GYS1/IFNAR2/AREG/CDC37/PPP2R2D/PPP2R2A/GNB1/NRAS/PIK3R6/VWF/CSH2/TNC/IFNAR1/YWHAZ/PDGFB/PDPK1/MET/EIF4B/GRB2/PPP2R3A/PPP2R3C/EFNA2/GNB4/MAPK1/ITGB3/FOXO3/PDGFA/RXRA/GNGT2/RPS6KB1/GNG4/TLR2/IL7/ATF2/IL2RA/MYC/PTEN/FLT3/PPP2R1B/INSR/PPP2R5A/FGF18/GSK3B/BCL2L1/PIK3R3/GNG7/ITGB7/CCND3/CASP9/GNG5/ITGA10/ITGB4/FLT4/CCNE2/LPAR3/LAMA3/RELN/PDGFD/LPAR1/GNB5/NTRK1/LPAR2/COL9A2/THBS3/EFNA1/IGF1R/FGFR1/LAMB1	4.00028741831691
Human Diseases	Endocrine and metabolic disease	hsa04936	Alcoholic liver disease	54/2187	144/9376	1.6076817558299	CXCL3/IL1B/CXCL2/MAP2K3/TRAF3/C3/NFKBIA/NFKB1/PRKAG2/CXCL8/AKT3/TICAM1/ALDH2/CXCL1/C5AR1/TAB2/IL6/IRAK1/FOXO1/MAPK13/TBK1/ADIPOR2/RIPK1/SCD/TCF7/SIRT1/TNF/CAMKK2/LPIN1/FAS/MYD88/CASP8/RELA/ACOX3/TCF7L2/ALDH3A2/SREBF1/MAPK8/CTNNB1/LPIN2/CPT1A/FOXO3/TRAF6/CASP3/TAB3/MAP2K4/GSK3B/ACOX1/MAP3K5/TRA2B/MAP3K14/ACACB/CPT1B/MAPK10	4.0530814745091
Environmental Information Processing	Signaling molecules and interaction	hsa04060	Cytokine-cytokine receptor interaction	98/2187	298/9376	1.40986856439669	CXCR4/CXCL3/IL1B/CXCL2/IL3RA/CCL20/IL1A/IL6R/CXCL8/IL15/RELT/CSF2RA/CCR7/CCL21/CSF3R/INHBA/IL1RN/CLCF1/IL18/CXCL1/IL6/TNFSF13B/OSM/TNFRSF10D/IL1R1/CSF2/CSF3/CXCL16/TNFRSF9/CCL18/TNFSF8/TNFSF13/TNFSF14/CCR5/IL10/TNF/IL1RAP/IL1RL2/CD40/IL7R/IL23A/FAS/IL2RG/IL4R/TGFB1/IL1R2/TNFRSF14/TNFRSF10A/IFNAR2/IL19/IFNGR2/TNFRSF10B/IL10RA/ACVR1/IL13RA1/TNFRSF1B/CRLF2/CSH2/IFNAR1/CCL14/IL1RL1/CXCL5/IL36B/TSLP/IL7/BMP6/IL2RA/IL15RA/CXCL12/BMP8A/TNFRSF18/LIF/ACVR1B/CCR3/CD70/IL12RB1/CXCL9/TNFSF15/IFNGR1/CXCL10/TNFRSF4/TNFRSF8/IL16/IFNLR1/ACKR3/TGFB2/IL20RB/TNFRSF10C/IL27RA/CCL3/GDF9/IL27/IL32/CXCL11/CCL3L1/CCR2/BMP2/BMPR1B	3.96582404276178
Cellular Processes	Cell growth and death	hsa04217	Necroptosis	61/2187	168/9376	1.55664423977181	TNFAIP3/IL1B/BCL2/STAT4/IL1A/CAPN2/CHMP4B/BIRC3/CYLD/CHMP1B/FTH1/CFLAR/STAT1/BID/TICAM1/BIRC2/GLUL/EIF2AK2/HSP90AB1/JAK1/CHMP2B/STAT5A/RIPK1/PPID/GLUD1/TNF/HSP90AA1/FAS/CASP1/CASP8/TNFRSF10A/IFNAR2/IRF9/VPS4B/IFNGR2/TNFRSF10B/SQSTM1/PLA2G4C/IFNAR1/MAPK8/STAT2/CHMP1A/PYGB/AIFM1/MLKL/TICAM2/STAT6/STAT5B/TRPM7/PPIAL4G/PYGM/IFNGR1/SPATA2L/STAT3/CAMK2D/TRAF2/PLA2G4A/TRAF5/FTL/MAPK10/ZBP1	4.01536928649589
Organismal Systems	Endocrine system	hsa04910	Insulin signaling pathway	52/2187	138/9376	1.61544833436048	RAPGEF1/PRKAG2/HK2/MAP2K1/PIK3CB/EIF4E/AKT3/INPP5A/FOXO1/RHEB/RHOQ/PTPN1/RAF1/IRS2/PIK3R1/TRIP10/SOCS1/RPTOR/FBP1/HK1/KRAS/GYS1/NRAS/SHC3/SREBF1/MAPK8/PDPK1/GRB2/MAPK1/INPPL1/PPP1R3B/PRKAR1B/BRAF/FLOT1/RPS6KB1/SORBS1/PYGB/MKNK2/CBL/INSR/SOCS4/ELK1/PRKCI/PYGM/PHKA2/HK3/GSK3B/PIK3R3/CALM1/PPP1R3E/ACACB/MAPK10	4.01714911447349
NA	NA	hsa04517	IgSF CAM signaling	98/2187	299/9376	1.40515328491711	ITGAX/ITGA5/CADM1/TJP2/SRC/SLAMF7/TUBB6/MAP2K1/PIK3CB/CD80/CD48/ACTN1/AKT3/TUBB4B/MBP/EZR/MSN/MYH9/RDX/CD226/NPHS1/FOXO1/MAPK13/RAPGEF2/PAK1/TUBA1C/TRIO/JAML/LCP2/PPFIA1/MYH11/ITGA4/NRP2/PIK3R1/FYN/PLCG2/IL1RAP/SLAMF1/CRTAM/TUBA4A/ICAM1/RHOA/NECTIN2/F11R/CD84/UNC5B/ACTR3/PTPN11/APP/LY9/MAPK8/SPTAN1/PDPK1/PRKCG/RAP1B/CABLES2/CTNNB1/PVR/GRB2/EPB41L3/CDC42/MAPK1/ITGB3/MYL9/TRAF6/SORBS1/NCAM1/VCL/CADM4/PLXNA1/KCNQ3/RAPGEF6/CD2AP/IQGAP1/RAP1A/PRKCI/CD244/KIRREL2/GSK3B/NECTIN1/PIK3R3/ITGB2/NTRK3/NTN1/MYLK3/ITGAM/SPTBN4/VAV2/ROBO3/PRKCB/LRFN4/ACTR3B/GLDN/NLGN3/ARPC5/MAPK10/NECTIN4/FGFR1	3.92698804189931
Environmental Information Processing	Signal transduction	hsa04330	Notch signaling pathway	28/2187	62/9376	1.93613286723601	NCOR2/HES1/NOTCH2/PSEN1/ADAM17/CTBP2/SPEN/LFNG/TLE3/CREBBP/NRARP/EP300/NUMB/MAML1/NOTCH1/DTX3L/SNW1/JAG1/DLL1/ATXN1/TLE1/KAT2B/DTX2/HEY1/MAML3/NOTCH4/DTX1/TLE2	4.07888075739151
Human Diseases	Cancer: overview	hsa05235	PD-L1 expression and PD-1 checkpoint pathway in cancer	37/2187	90/9376	1.76249555453945	MAP2K3/NFKBIA/NFKB1/MAP2K1/PIK3CB/AKT3/STAT1/NFKBIE/TICAM1/NFATC1/JAK1/MAPK13/RAF1/CD274/PIK3R1/PPP3CC/NFKBIB/MYD88/KRAS/RELA/IFNGR2/NRAS/PTPN11/MAPK1/TRAF6/RPS6KB1/TLR2/TICAM2/PTEN/EML4/LAT/IFNGR1/BATF3/PIK3R3/STAT3/RASGRP1/HIF1A	4.00885196179227
Human Diseases	Infectious disease: parasitic	hsa05146	Amoebiasis	41/2187	103/9376	1.70653597382592	CXCL3/IL1B/CXCL2/NFKB1/PIK3CB/CXCL8/ACTN1/RAB7A/SERPINB9/CXCL1/IL6/GNAL/SERPINB10/IL1R1/CSF2/RAB5A/RAB7B/PIK3R1/IL10/FN1/TNF/TGFB1/LAMB3/IL1R2/RELA/GNA15/PRKCG/TLR2/CASP3/VCL/CD1D/HSPB1/GNAQ/PIK3R3/ITGB2/CD1C/ITGAM/PRKCB/LAMA3/TGFB2/LAMB1	3.97666081202893
Organismal Systems	Immune system	hsa04666	Fc gamma R-mediated phagocytosis	39/2187	98/9376	1.7061112510848	SPHK1/FCGR2B/MAP2K1/PIK3CB/AKT3/MARCKSL1/PAK1/PRKCE/RAF1/PIK3R1/PLCG2/PLA2G6/PLA2G4C/LIMK1/ACTR3/PRKCG/PIP5K1A/CDC42/PIP5K1C/VASP/MAPK1/INPPL1/PRKCD/RPS6KB1/FCGR2A/DNM2/GAB2/ASAP1/LAT/PIK3R3/GSN/MARCKS/VAV2/NCF1/PLA2G4A/PRKCB/ACTR3B/ARPC5/PLPP1	3.87556275160708
Human Diseases	Cancer: specific types	hsa05223	Non-small cell lung cancer	31/2187	73/9376	1.82057112075715	CDKN1A/MAP2K1/PIK3CB/RASSF5/AKT3/GADD45A/GADD45G/GADD45B/STAT5A/RAF1/PIK3R1/PLCG2/KRAS/NRAS/KIF5B/PDPK1/PRKCG/MET/GRB2/MAPK1/DDB2/FOXO3/RXRA/BRAF/EML4/E2F3/STAT5B/PIK3R3/STAT3/PRKCB/CASP9	3.88187847891046
Genetic Information Processing	Chromosome	hsa03083	Polycomb repressive complex	34/2187	83/9376	1.75618248026399	EZH2/JARID2/UBE2D1/L3MBTL4/PHF19/RYBP/PCGF5/TEX10/USP7/USP16/PHC2/YAF2/ASXL1/CREBBP/EP300/FBRSL1/TFDP1/FBRS/SFMBT2/FOXK2/BCOR/RNF2/UBE2D2/PHF1/MAX/E2F6/YY1/CBX4/OGT/UBE2D3/LCOR/EPOP/SKP1/BCORL1	3.81648426922264
Human Diseases	Endocrine and metabolic disease	hsa04931	Insulin resistance	42/2187	109/9376	1.65192987754999	NFKBIA/NFKB1/PRKAG2/PIK3CB/AKT3/RPS6KA3/CREB5/IL6/FOXO1/PTPN1/PRKCE/IRS2/PIK3R1/TNF/RELA/GYS1/PTPN11/SREBF1/MAPK8/PDPK1/CPT1A/PRKCD/PPP1R3B/RPS6KB1/PYGB/OGT/RPS6KA2/NR1H3/PTEN/GFPT1/INSR/PYGM/GSK3B/PPARGC1B/PIK3R3/STAT3/SLC27A1/PRKCB/PPP1R3E/ACACB/CPT1B/MAPK10	3.77589875053953
Organismal Systems	Immune system	hsa04650	Natural killer cell mediated cytotoxicity	49/2187	133/9376	1.57947681274517	HLA-A/HLA-B/PTK2B/MAP2K1/PIK3CB/CD48/BID/HLA-E/NFATC1/HLA-C/PAK1/CSF2/LCP2/RAF1/PIK3R1/FYN/TNF/PLCG2/FAS/PPP3CC/LAT2/KRAS/ICAM1/TNFRSF10A/IFNAR2/IFNGR2/TNFRSF10B/NRAS/SHC3/PTPN11/IFNAR1/PRKCG/GRB2/MAPK1/BRAF/TYROBP/CASP3/HLA-G/KLRD1/CD244/LAT/IFNGR1/PIK3R3/ITGB2/ULBP3/VAV2/PRKCB/MICB/ULBP2	3.71219853160025
Organismal Systems	Immune system	hsa04622	RIG-I-like receptor signaling pathway	30/2187	72/9376	1.78631306203323	TRAF3/ZNFX1/NFKBIA/NFKB1/CXCL8/IFIH1/CYLD/IRF7/MAPK13/TBK1/TRIM25/ADAR/TANK/RIPK1/ISG15/TNF/NFKBIB/CASP8/RELA/AZI2/OTUD5/MAPK8/ATG12/DHX58/TRAF6/TKFC/CXCL10/TRAF2/DDX3X/MAPK10	3.6940491999647
Environmental Information Processing	Signal transduction	hsa04015	Rap1 signaling pathway	71/2187	212/9376	1.43579125363425	VEGFA/RAPGEF1/MAP2K3/SIPA1L1/TIAM1/MRAS/SRC/DOCK4/MAP2K1/PIK3CB/RASSF5/RALGDS/AKT3/RALA/RASGRP3/ADCY3/THBS1/ADORA2A/MAPK13/RAPGEF2/LCP2/RAF1/ADORA2B/PIK3R1/KRAS/RHOA/TLN1/NRAS/APBB1IP/FARP2/PDGFB/FPR1/PRKCG/RAP1B/MET/CTNNB1/EFNA2/CDC42/VASP/MAPK1/ITGB3/PDGFA/BRAF/RALB/RASGRP2/ADCY9/GNAI3/RAPGEF6/INSR/RAP1A/PRKCI/FGF18/CNR1/LAT/GNAQ/P2RY1/PIK3R3/ITGB2/ITGAM/CALM1/VAV2/PRKCB/FLT4/RAPGEF4/LPAR3/PDGFD/LPAR1/LPAR2/EFNA1/IGF1R/FGFR1	3.53980784806163
Organismal Systems	Immune system	hsa04660	T cell receptor signaling pathway	45/2187	122/9376	1.58132631720974	NFKBIA/NFKB1/MALT1/MAP2K1/PIK3CB/AKT3/NFKBIE/NFATC1/MAPK13/PAK1/CSF2/LCP2/RAF1/PIK3R1/BCL10/FYN/PPP2CA/IL10/TNF/PPP3CC/NFKBIB/KRAS/RELA/RHOA/PPP2R2D/PPP2R2A/NRAS/PTPN11/MAPK8/PDPK1/GRB2/PPP2R3A/PPP2R3C/CDC42/MAPK1/CARD11/PPP2R1B/PPP2R5A/LAT/GSK3B/PIK3R3/VAV2/MAP3K14/RASGRP1/MAPK10	3.5646011264751
Environmental Information Processing	Signal transduction	hsa04014	Ras signaling pathway	78/2187	238/9376	1.40503279501101	VEGFA/TIAM1/MRAS/NFKB1/ABL2/MAP2K1/PIK3CB/RASSF5/RALGDS/AKT3/ETS2/RALA/RASGRP3/REL/RASA3/TBK1/PAK1/RAB5A/RAF1/PIK3R1/PLCG2/KRAS/RELA/RHOA/HTR7/PLA2G6/SHOC2/GNB1/PLA2G4C/NRAS/SHC3/PTPN11/MAPK8/PDGFB/PRKCG/RAP1B/MET/PLA1A/GRB2/EFNA2/CDC42/GNB4/MAPK1/PDGFA/GNGT2/GNG4/RALB/BRAP/RASGRP2/FLT3/INSR/ELK1/RAP1A/GAB2/FGF18/KSR1/LAT/RASAL2/BCL2L1/RASGRF1/PIK3R3/CALM1/GNG7/PLA2G4A/PRKCB/GNG5/SYNGAP1/FLT4/RASGRP1/PDGFD/GNB5/NTRK1/MAPK10/RIN1/RASA4B/EFNA1/IGF1R/FGFR1	3.49083143798882
Organismal Systems	Endocrine system	hsa03320	PPAR signaling pathway	31/2187	76/9376	1.74870647125358	OLR1/PLIN2/UBC/ACSL5/APOA2/ACSL3/PPARD/APOC3/ACSL1/HMGCS1/ACSL4/SCD/ACOX3/PPARG/APOA1/LPL/PDPK1/CPT1A/FABP5/GK/FABP3/RXRA/SORBS1/CYP27A1/NR1H3/ACOX1/PLIN5/DBI/SLC27A1/ME3/CPT1B	3.61453718225289
Human Diseases	Cancer: specific types	hsa05214	Glioma	31/2187	76/9376	1.74870647125358	CDKN1A/MAP2K1/PIK3CB/CAMK1D/AKT3/GADD45A/GADD45G/GADD45B/RAF1/MDM2/PIK3R1/PLCG2/KRAS/CAMK1/NRAS/SHC3/PDGFB/PRKCG/GRB2/MAPK1/DDB2/PDGFA/BRAF/PTEN/E2F3/CAMK1G/PIK3R3/CALM1/CAMK2D/PRKCB/IGF1R	3.61453718225289
Human Diseases	Cancer: overview	hsa05231	Choline metabolism in cancer	38/2187	99/9376	1.64557324502455	GPCPD1/MAP2K1/PIK3CB/RALGDS/AKT3/SLC22A4/SLC22A1/RHEB/RAF1/PIK3R1/KRAS/CHKA/DGKD/PLA2G4C/NRAS/DGKA/MAPK8/PDGFB/PDPK1/PRKCG/PIP5K1A/GRB2/PIP5K1C/MAPK1/PCYT1A/SLC44A1/PDGFA/RPS6KB1/CHPT1/PIK3R3/SP1/PLA2G4A/PRKCB/SLC22A5/PDGFD/MAPK10/HIF1A/PLPP1	3.56151789000659
Environmental Information Processing	Signal transduction	hsa04350	TGF-beta signaling pathway	41/2187	110/9376	1.597938230037	SMAD7/EMP3/SKIL/INHBA/CUL1/ID2/THBS1/HAMP/SKI/PPP2CA/TNF/ZFYVE16/TGIF2/TGIF1/SMAD3/CREBBP/TGFB1/EP300/TF/RHOA/SIN3A/TFDP1/SMURF1/ACVR1/LEMD3/SMURF2/SMAD2/CDKN2B/MAPK1/RPS6KB1/TFRC/BMP6/MYC/PPP2R1B/BMP8A/ACVR1B/SP1/SKP1/TGFB2/BMP2/BMPR1B	3.47922330811958
Environmental Information Processing	Signaling molecules and interaction	hsa04061	Viral protein interaction with cytokine and cytokine receptor	38/2187	100/9376	1.6291175125743	CXCR4/CXCL3/CXCL2/CCL20/IL6R/CXCL8/CCR7/CCL21/IL18/CXCL1/IL6/TNFRSF10D/CCL18/TNFSF14/CCR5/IL10/TNF/IL2RG/TNFRSF14/TNFRSF10A/IL19/TNFRSF10B/IL10RA/TNFRSF1B/CCL14/CXCL5/IL2RA/CXCL12/CCR3/CXCL9/CXCL10/ACKR3/IL20RB/TNFRSF10C/CCL3/CXCL11/CCL3L1/CCR2	3.48840734801759
Metabolism	Lipid metabolism	hsa00600	Sphingolipid metabolism	24/2187	55/9376	1.87075695223843	B4GALT5/SPHK1/SGMS2/PSAP/SGPP2/GM2A/UGCG/GLA/SAMD8/CERK/SGPL1/HEXB/KDSR/NEU3/CERS5/GALC/HEXA/SMPD4/NEU4/ACER2/SMPD2/ASAH1/PLPP1/CERS6	3.57209359214466
Human Diseases	Cancer: overview	hsa05230	Central carbon metabolism in cancer	29/2187	71/9376	1.7510899875706	SLC7A5/HK2/MAP2K1/PIK3CB/AKT3/GLS/SLC16A3/SCO2/RAF1/PIK3R1/LDHA/HK1/KRAS/PFKP/NRAS/MET/MAPK1/SLC1A5/LDHC/MYC/PTEN/FLT3/HK3/PDK1/PIK3R3/NTRK3/NTRK1/HIF1A/FGFR1	3.5037954650169
Environmental Information Processing	Signal transduction	hsa04072	Phospholipase D signaling pathway	52/2187	149/9376	1.49618704793119	PIK3R5/SPHK1/MRAS/PTK2B/MAP2K1/PIK3CB/CXCL8/RALGDS/AKT3/RALA/GNA12/ADCY3/RHEB/RAF1/PIK3R1/FYN/PLCG2/GNA13/AGPAT4/KRAS/RHOA/DGKD/PLA2G4C/NRAS/PIK3R6/SHC3/CYTH1/PTPN11/DGKA/PDGFB/ARF1/CYTH3/PIP5K1A/GRB2/PIP5K1C/MAPK1/PDGFA/RALB/ADCY9/DNM2/INSR/GAB2/PIK3R3/AGPAT5/PLA2G4A/RAPGEF4/LPAR3/DNM3/PDGFD/LPAR1/LPAR2/PLPP1	3.36731763987784
Human Diseases	Infectious disease: bacterial	hsa05133	Pertussis	31/2187	78/9376	1.70386784378554	IL1B/ITGA5/IRF1/C3/IL1A/NFKB1/CXCL8/TICAM1/IL6/IRAK1/MAPK13/IRF8/IL10/TNF/SERPING1/IL23A/CASP1/MYD88/RELA/RHOA/MAPK8/MAPK1/TRAF6/CXCL5/CASP3/GNAI3/TICAM2/ITGB2/ITGAM/CALM1/MAPK10	3.4428606363343
Environmental Information Processing	Signal transduction	hsa04152	AMPK signaling pathway	44/2187	122/9376	1.54618573238286	PRKAG2/PFKFB3/PIK3CB/AKT3/TBC1D1/CREB5/FOXO1/RHEB/ADIPOR2/IRS2/SCD/PIK3R1/RAB8A/PPP2CA/SIRT1/CAMKK2/RPTOR/FBP1/PFKP/GYS1/PPP2R2D/PPP2R2A/PPARG/SREBF1/PDPK1/CPT1A/PPP2R3A/PPP2R3C/FOXO3/RAB10/RPS6KB1/PFKFB4/PPP2R1B/INSR/PPP2R5A/AKT1S1/EEF2/PIK3R3/CAB39L/ULK1/CAB39/ACACB/CPT1B/IGF1R	3.34912461259536
Organismal Systems	Immune system	hsa04664	Fc epsilon RI signaling pathway	28/2187	69/9376	1.73971359084975	MAP2K3/MAP2K1/PIK3CB/AKT3/MAPK13/CSF2/LCP2/RAF1/PIK3R1/FYN/TNF/PLCG2/KRAS/PLA2G4C/NRAS/BTK/MAPK8/PDPK1/GRB2/MAPK1/GAB2/MAP2K4/LAT/PIK3R3/VAV2/PLA2G4A/ALOX5/MAPK10	3.4014107069442
Cellular Processes	Cell motility	hsa04820	Cytoskeleton in muscle cells	75/2187	233/9376	1.37998433976816	AMPD3/ITGA5/VIM/ITGB8/SNTB1/DIAPH1/LMNA/SDC4/ITGAV/SDC2/PLEC/THBS1/MYH9/FMNL3/ACTG2/ATP1A1/MYH11/INF2/DES/SUN2/ITGA4/CSRP1/FN1/EMD/FMNL1/TLN1/SDC3/ENO1/ZYX/TMOD3/SPTAN1/SYNPO2/FMNL2/ITGB3/MYL9/JUP/VCL/AMPD2/AGRN/FHL3/ATP1B3/TTN/TNNI2/FBN2/LMNB1/TMEM43/DSC2/SYNE1/C10orf71/TMOD2/COL24A1/ENO3/SPTBN4/ITGB7/TPM4/LMOD2/ITGA10/ITGB4/PDLIM1/MYBPC3/ACTN2/PDLIM3/SYNE3/NEB/MYOM1/MYBPC2/OBSCN/CAPN3/TPM3/ATP1B2/COL9A2/THBS3/LMOD3/PKP2/LMOD1	3.23947838875591
Environmental Information Processing	Signal transduction	hsa04012	ErbB signaling pathway	33/2187	86/9376	1.6450697036399	CDKN1A/EREG/SRC/ABL2/MAP2K1/PIK3CB/AKT3/PAK1/STAT5A/RAF1/PIK3R1/HBEGF/PLCG2/KRAS/AREG/NRAS/SHC3/MAPK8/PRKCG/GRB2/MAPK1/BRAF/RPS6KB1/CBL/MYC/ELK1/STAT5B/MAP2K4/GSK3B/PIK3R3/CAMK2D/PRKCB/MAPK10	3.31454410111715
Human Diseases	Immune disease	hsa05320	Autoimmune thyroid disease	23/2187	54/9376	1.82600890785619	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/HLA-DRA/HLA-DOA/HLA-A/HLA-B/HLA-F/CD80/HLA-DMB/HLA-E/HLA-DQB2/HLA-C/IL10/CD40/FAS/HLA-G/TG	3.35739817016911
Organismal Systems	Aging	hsa04211	Longevity regulating pathway	34/2187	90/9376	1.61959050957679	SOD2/NFKB1/PRKAG2/PIK3CB/EIF4E/AKT3/ADCY3/CREB5/FOXO1/RHEB/ATF4/RB1CC1/ADIPOR2/IRS2/PIK3R1/SIRT1/CAMKK2/ATG13/RPTOR/KRAS/RELA/SESN2/PPARG/ATG101/NRAS/FOXO3/RPS6KB1/ADCY9/ATF2/INSR/AKT1S1/PIK3R3/ULK1/IGF1R	3.25752276854263
Organismal Systems	Digestive system	hsa04978	Mineral absorption	25/2187	61/9376	1.75702924134416	FTH1/VDR/MT1M/ATP2B1/ATP1A1/SLC30A1/MT1G/MT1H/MT1A/SLC31A1/TF/HMOX1/MT1F/MT1X/SLC11A2/SLC8A2/SLC8A1/MT1E/ATP1B3/MT2A/TRPM7/SLC26A3/FTL/ATP1B2/FXYD2	3.27161304257567
Organismal Systems	Endocrine system	hsa04917	Prolactin signaling pathway	28/2187	71/9376	1.6907075742061	IRF1/SRC/NFKB1/MAP2K1/PIK3CB/AKT3/STAT1/MAPK13/STAT5A/RAF1/PIK3R1/SOCS1/KRAS/RELA/NRAS/SHC3/MAPK8/SOCS6/GRB2/MAPK1/FOXO3/ESR1/SOCS4/STAT5B/GSK3B/PIK3R3/STAT3/MAPK10	3.22211466828888
Human Diseases	Drug resistance: antineoplastic	hsa01524	Platinum drug resistance	29/2187	75/9376	1.65769852156683	CDKN1A/BCL2/PIK3CB/BIRC3/AKT3/BID/BIRC2/CYCS/PMAIP1/MDM2/GSTO2/PIK3R1/REV3L/FAS/SLC31A1/GSTO1/CASP8/ERCC1/PDPK1/MAPK1/MLH1/TOP2B/CASP3/POLH/BCL2L1/MAP3K5/PIK3R3/CASP9/ABCC2	3.15404919587857
Organismal Systems	Aging	hsa04213	Longevity regulating pathway - multiple species	25/2187	62/9376	1.72869006003215	SOD2/PRKAG2/PIK3CB/AKT3/HSPA6/ADCY3/FOXO1/IRS2/PIK3R1/SIRT1/RPTOR/CRYAB/KRAS/HSPA8/NRAS/HSPA1B/FOXO3/RPS6KB1/ADCY9/HSPA1A/HSPA1L/INSR/AKT1S1/PIK3R3/IGF1R	3.17501923924894
Human Diseases	Cardiovascular disease	hsa05418	Fluid shear stress and atherosclerosis	48/2187	142/9376	1.44917792074808	VEGFA/IL1B/BCL2/SRC/IL1A/NFKB1/PIK3CB/SDC4/AKT3/THBD/ITGAV/NFE2L2/SDC2/ARHGEF2/HSP90AB1/MAPK13/MMP9/TXN/IL1R1/GSTO2/PIK3R1/TNF/HSP90AA1/GSTO1/IL1R2/ICAM1/RELA/RHOA/HMOX1/SQSTM1/ACVR1/MAPK8/PDGFB/CTNNB1/ITGB3/PDGFA/NCF2/CTSL/MAP2K4/EDN1/MAP3K5/PIK3R3/CALM1/NCF1/TRPV4/DUSP1/MAPK10/BMPR1B	2.97470172605244
Human Diseases	Cancer: specific types	hsa05219	Bladder cancer	18/2187	41/9376	1.88216400682525	CDKN1A/VEGFA/SRC/MAP2K1/CXCL8/TYMP/THBS1/MMP9/RAF1/MDM2/HBEGF/KRAS/NRAS/MAPK1/BRAF/MYC/E2F3/DAPK1	3.12219403226184
Environmental Information Processing	Signal transduction	hsa04370	VEGF signaling pathway	24/2187	60/9376	1.7148605395519	VEGFA/PTGS2/SPHK1/SRC/MAPKAPK2/MAP2K1/PIK3CB/AKT3/MAPK13/RAF1/PIK3R1/PLCG2/PPP3CC/KRAS/PLA2G4C/NRAS/PRKCG/CDC42/MAPK1/HSPB1/PIK3R3/PLA2G4A/PRKCB/CASP9	3.06378296957094
Cellular Processes	Cell growth and death	hsa04215	Apoptosis - multiple species	15/2187	32/9376	2.00960219478738	BCL2/BIRC3/BID/BIRC2/CYCS/BCL2L11/PMAIP1/CASP8/BECN1/MAPK8/CASP3/BCL2L1/CASP9/DIABLO/MAPK10	3.15525634109724
Human Diseases	Immune disease	hsa05310	Asthma	15/2187	32/9376	2.00960219478738	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/HLA-DRA/HLA-DOA/HLA-DMB/HLA-DQB2/IL10/TNF/CD40	3.15525634109724
NA	NA	hsa04518	Integrin signaling	51/2187	154/9376	1.41977090125238	ITGAX/VEGFA/ITGA5/LIMS1/C3/SRC/ITGB8/PIK3CB/FLNA/ACTN1/AKT3/ITGAV/THBS1/ITGAD/ITGA4/PIK3R1/FN1/PARVB/TGFB1/LAMB3/ICAM1/TLN1/PARVG/VWF/LIMS2/TNC/PDGFB/MET/CTNNB1/CDC42/ITGB3/PDGFA/VCL/ICAM4/GSK3B/PIK3R3/ITGB2/ITGAM/ITGB7/CCND3/ITGA10/ITGB4/FLT4/FLNB/LAMA3/RELN/PDGFD/COL9A2/THBS3/IGF1R/LAMB1	2.89691611152269
Human Diseases	Cancer: specific types	hsa05224	Breast cancer	49/2187	148/9376	1.41939470334532	CDKN1A/NFKB2/MAP2K1/PIK3CB/AKT3/HES1/GADD45A/NOTCH2/GADD45G/GADD45B/RAF1/TCF7/PIK3R1/KRAS/NOTCH1/BRCA2/NRAS/TCF7L2/WNT2B/SHC3/CTNNB1/GRB2/MAPK1/JAG1/DDB2/BRAF/RPS6KB1/AXIN1/ESR1/MYC/PTEN/DLL1/E2F3/FGF18/APC2/GSK3B/PIK3R3/CSNK1A1/NCOA3/SP1/WNT5A/FLT4/WNT5B/HEY1/WNT9A/NOTCH4/FZD8/IGF1R/FGFR1	2.83645432136688
Organismal Systems	Immune system	hsa04670	Leukocyte transendothelial migration	40/2187	116/9376	1.47832805133784	CXCR4/PTK2B/PIK3CB/RASSF5/ACTN1/EZR/MSN/RHOH/MAPK13/MMP9/ITGA4/PIK3R1/PLCG2/ICAM1/RHOA/F11R/CTNNA1/PTPN11/PRKCG/RAP1B/CTNNB1/CDC42/VASP/MYL9/CLDN1/VCL/GNAI3/CLDN12/CXCL12/NCF2/RAP1A/CLDN14/PIK3R3/ITGB2/ITGAM/VAV2/NCF1/PRKCB/RAPGEF4/CLDN4	2.85907231257759
Organismal Systems	Digestive system	hsa04979	Cholesterol metabolism	21/2187	52/9376	1.73134958320144	APOA2/SOAT1/APOC3/NPC1/APOC2/ABCA1/APOE/LDLR/VAPA/LIPA/APOA1/LPL/MYLIP/APOB/VAPB/NCEH1/CYP27A1/SORT1/SCARB1/LIPC/CETP	2.91676436562591
Environmental Information Processing	Signaling molecules and interaction	hsa04514	Cell adhesion molecule (CAM) interaction	52/2187	160/9376	1.39332418838592	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/ALCAM/CADM1/CD58/HLA-DRA/HLA-DOA/ITGB8/HLA-A/HLA-B/HLA-F/CD80/CD22/SDC4/HLA-DMB/ITGAV/SDC2/HLA-E/HLA-DQB2/CD226/HLA-C/JAML/ITGA4/CD274/CD40/VSIR/ICAM1/SELL/NECTIN2/SDC3/F11R/ICOSLG/SPN/PVR/CLDN1/NCAM1/HLA-G/CLDN12/CLDN14/NECTIN1/CD6/ITGB2/ITGAM/ITGB7/NLGN3/CLDN4	2.76767570443026
Cellular Processes	Cellular community - eukaryotes	hsa04520	Adherens junction	33/2187	93/9376	1.5212472528283	SRC/ACTN1/PTPN1/SNAI1/TCF7/FYN/SMAD3/CREBBP/EP300/RHOA/NECTIN2/SMURF1/SMURF2/CTNNA1/TCF7L2/FARP2/RAP1B/MET/CTNNB1/CDC42/MAPK1/MYL9/SORBS1/VCL/IQGAP1/INSR/RAP1A/NECTIN1/RADIL/IGF1R/PTPRJ/NECTIN4/FGFR1	2.78622937120538
Organismal Systems	Endocrine system	hsa04935	Growth hormone synthesis, secretion and action	41/2187	122/9376	1.44076397790221	MAP2K3/ITPR1/MAP2K1/PIK3CB/AKT3/STAT1/ADCY3/CREB5/SSTR2/MAPK13/ATF4/STAT5A/RAF1/IRS2/PIK3R1/SOCS1/PLCG2/CREBBP/EP300/ADCY10/KRAS/NRAS/SHC3/CSH2/MAPK8/PRKCG/GRB2/MAPK1/ADCY9/GNAI3/ATF2/STAT5B/GHRL/MAP2K4/GSK3B/GNAQ/PIK3R3/STAT3/CACNA1D/PRKCB/MAPK10	2.70269507095615
Organismal Systems	Endocrine system	hsa04920	Adipocytokine signaling pathway	26/2187	70/9376	1.59237050101248	NFKBIA/NFKB1/PRKAG2/ACSL5/AKT3/NFKBIE/ACSL3/ACSL1/ADIPOR2/ACSL4/IRS2/TNF/CAMKK2/NFKBIB/RELA/TNFRSF1B/PTPN11/MAPK8/CPT1A/RXRA/STAT3/TRAF2/AGRP/ACACB/CPT1B/MAPK10	2.74370052979223
Organismal Systems	Immune system	hsa04611	Platelet activation	42/2187	126/9376	1.42905044962658	PIK3R5/SRC/ITPR1/PIK3CB/AKT3/ADCY3/MAPK13/LCP2/PIK3R1/FYN/PLCG2/GNA13/RHOA/TLN1/PTGS1/PLA2G4C/PIK3R6/P2RX1/VWF/APBB1IP/BTK/RAP1B/GP6/VASP/MAPK1/ITGB3/RASGRP2/ADCY9/FCGR2A/GNAI3/RAP1A/PRKCI/GNAQ/P2RY1/PPP1R12A/PIK3R3/MYLK3/SNAP23/PLA2G4A/PTGIR/RASGRP1/ADAMTS13	2.6742287625629
Human Diseases	Endocrine and metabolic disease	hsa04930	Type II diabetes mellitus	19/2187	47/9376	1.73310373678117	HK2/PIK3CB/PRKCE/IRS2/PIK3R1/TNF/SOCS1/HK1/MAPK8/MAPK1/PRKCD/CACNA1G/INSR/SOCS4/MAFA/HK3/PIK3R3/CACNA1D/MAPK10	2.77889798296756
Organismal Systems	Excretory system	hsa04960	Aldosterone-regulated sodium reabsorption	16/2187	38/9376	1.80511635742305	SGK1/PIK3CB/ATP1A1/NEDD4L/PIK3R1/KRAS/PDPK1/PRKCG/MAPK1/ATP1B3/INSR/PIK3R3/HSD11B2/PRKCB/ATP1B2/FXYD2	2.74283259373398
Genetic Information Processing	Folding, sorting and degradation	hsa03018	RNA degradation	28/2187	78/9376	1.53897740729016	BTG1/BTG3/PABPC4/TENT4A/PABPC1/HSPA9/CNOT1/TOB1/DCP1A/HSPD1/DDX6/PFKP/PATL1/DHX36/ENO1/CNOT6/TOB2/DCP2/DIS3/CNOT4/TENT4B/PNPT1/CNOT6L/CNOT2/ZCCHC7/ENO3/PABPC1L/PNLDC1	2.63632458254225
Human Diseases	Drug resistance: antineoplastic	hsa01522	Endocrine resistance	34/2187	99/9376	1.47235500870617	CDKN1A/BCL2/SRC/MAP2K1/PIK3CB/AKT3/ADCY3/NOTCH2/MAPK13/MMP9/RAF1/MDM2/PIK3R1/HBEGF/KRAS/NOTCH1/NRAS/SHC3/MAPK8/GRB2/MAPK1/JAG1/BRAF/RPS6KB1/ESR1/ADCY9/DLL1/E2F3/PIK3R3/NCOA3/SP1/MAPK10/NOTCH4/IGF1R	2.60590231535585
Cellular Processes	Transport and catabolism	hsa04136	Autophagy - other	14/2187	32/9376	1.87562871513489	GABARAPL1/PPP2CA/ATG13/RPTOR/ATG4B/IGBP1/ATG101/BECN1/ATG16L1/ATG12/ATG2A/ATG4A/WIPI1/ATG2B	2.73655611105128
Genetic Information Processing	Information processing in viruses	hsa03265	Virion - Ebolavirus, Lyssavirus and Morbillivirus	7/2187	12/9376	2.50083828684652	FCGR2B/NPC1/SLAMF1/ASGR1/NCAM1/CD46/NECTIN4	2.86925804877009
Human Diseases	Cardiovascular disease	hsa05412	Arrhythmogenic right ventricular cardiomyopathy	30/2187	86/9376	1.49551791239991	ITGA5/ITGB8/SNTB1/LMNA/ITGAV/ATP2A2/DES/ITGA4/TCF7/EMD/CTNNA1/TCF7L2/CTNNB1/ITGB3/ATP2A3/JUP/SLC8A2/SLC8A1/CACNA2D4/DSC2/CACNB2/CACNA1D/ITGB7/ATP2A1/ITGA10/ITGB4/ACTN2/CACNG2/CACNB1/PKP2	2.54610620259397
Environmental Information Processing	Signal transduction	hsa04022	cGMP-PKG signaling pathway	52/2187	166/9376	1.34296307314305	KCNMA1/PIK3R5/PPIF/ITPR1/MAP2K1/AKT3/GNA12/ADCY3/NFATC1/CREB5/ATP2B1/ATP1A1/ATP2A2/ATF4/RGS2/PRKCE/PDE2A/RAF1/IRS2/GNA13/ADRB2/MEF2D/PPP3CC/RHOA/KCNMB1/PIK3R6/KCNMB4/ADRA2B/VASP/MAPK1/ATP2A3/MYL9/ADCY9/SLC8A2/SLC8A1/GNAI3/ATF2/ATP1B3/INSR/ADORA3/ADRA2C/GNAQ/PPP1R12A/MYLK3/CALM1/CACNA1D/ATP2A1/SRF/PLN/ATP1B2/FXYD2/CNGB1	2.45893686967006
Environmental Information Processing	Signal transduction	hsa04024	cAMP signaling pathway	68/2187	226/9376	1.28993934391072	TIAM1/NFKBIA/NFKB1/MAP2K1/PIK3CB/AKT3/ADCY3/NFATC1/CREB5/SSTR2/PDE4A/ADORA2A/ATP2B1/SLC9A1/ATP1A1/PAK1/HCAR3/ATP2A2/PTGER2/RAF1/PIK3R1/HCAR2/PDE4B/CREBBP/ADRB2/EP300/ADCY10/RELA/RHOA/POPDC2/ACOX3/GIPR/PDE4C/MAPK8/RAP1B/MAPK1/SUCNR1/ATP2A3/BRAF/MYL9/ADCY9/OXTR/GNAI3/ATP1B3/GABBR1/FFAR2/RAP1A/GHRL/EDN1/ACOX1/CRH/PPP1R12A/PIK3R3/CALM1/CACNA1D/CAMK2D/VAV2/HCN2/PTGER3/ATP2A1/RAPGEF4/PLN/CNGA4/GRIN2D/ATP1B2/MAPK10/FXYD2/CNGB1	2.43347344985384
Organismal Systems	Endocrine system	hsa04928	Parathyroid hormone synthesis, secretion and action	38/2187	115/9376	1.41662392397765	CDKN1A/BCL2/ITPR1/SGK1/MAP2K1/RUNX2/VDR/GNA12/ADCY3/CREB5/PDE4A/AKAP13/ATF4/OXSR1/RAF1/HBEGF/PDE4B/GNA13/MEF2D/RHOA/MAFB/PDE4C/PRKCG/MAPK1/RXRA/BRAF/MMP24/ADCY9/GNAI3/ATF2/STK39/WNK1/GNAQ/SP1/PRKCB/JUND/CASR/FGFR1	2.47936217300228
Genetic Information Processing	Folding, sorting and degradation	hsa04130	SNARE interactions in vesicular transport	14/2187	33/9376	1.81879148134292	STX11/STX3/STX4/STX5/SEC22B/STX6/VAMP3/VAMP5/STX18/VAMP4/VAMP7/SNAP23/STX1B/VAMP1	2.59874040629548
Genetic Information Processing	Information processing in viruses	hsa03250	Viral life cycle - HIV-1	26/2187	73/9376	1.52693061740922	CXCR4/MX1/MX2/CHMP4B/ELL2/SUPT5H/MDFIC/ELL/CCR5/CREBBP/EP300/TNPO3/APOBEC3A/CPSF7/VPS4B/NUP153/CCNT2/PDCD6IP/BICD2/HGS/SAMHD1/AFF4/RANBP2/PPIAL4G/KAT2B/NELFB	2.49275239142279
Genetic Information Processing	Folding, sorting and degradation	hsa04120	Ubiquitin mediated proteolysis	45/2187	142/9376	1.35860430070133	UBE2D1/UBC/BIRC3/CUL1/BIRC2/UBE2R2/UBE2S/UBE2Q2/UBE2Z/UBE2H/NEDD4L/UBE2N/MDM2/UBE2A/SOCS1/UBE2E1/UBR5/UBE2J1/SIAH1/FZR1/UBE2L6/HUWE1/UBE2O/CUL3/UBA1/SMURF1/SAE1/SMURF2/UBE2D2/ELOC/DDB1/TRIP12/UBE2Q1/UBE2E2/CUL4A/DDB2/TRAF6/UBE2G1/CBL/UBE2D3/UBE3A/FBXW7/FANCL/SKP1/COP1	2.37487370369734
Cellular Processes	Cell motility	hsa04810	Regulation of actin cytoskeleton	69/2187	232/9376	1.27505794427889	ITGAX/CXCR4/ITGA5/TIAM1/MRAS/SRC/ITGB8/MAP2K1/PIK3CB/DIAPH1/RGCC/ACTN1/AKT3/ITGAV/SSH1/EZR/GNA12/MSN/MYH9/RDX/ITGAD/SLC9A1/PAK1/MYH11/RAF1/ITGA4/IQGAP2/PIK3R1/FN1/GNA13/SPATA13/KRAS/RHOA/NRAS/LIMK1/ACTR3/PDGFB/PIP5K1A/CDC42/PIP5K1C/ARHGEF7/MAPK1/ITGB3/PDGFA/BRAF/MYL9/VCL/IQGAP1/CXCL12/FGF18/APC2/CYFIP2/PPP1R12A/PIK3R3/ITGB2/MYLK3/ITGAM/GSN/VAV2/ITGB7/ITGA10/ITGB4/ACTR3B/SSH2/ARPC5/PDGFD/LPAR1/LPAR2/FGFR1	2.33978452622341
Human Diseases	Infectious disease: parasitic	hsa05144	Malaria	19/2187	50/9376	1.6291175125743	IL1B/CXCL8/SDC2/IL18/THBS1/IL6/CSF3/IL10/TNF/CD40/TGFB1/MYD88/ICAM1/MET/ACKR1/TLR2/ITGB2/TGFB2/THBS3	2.46005524007436
Human Diseases	Cardiovascular disease	hsa05410	Hypertrophic cardiomyopathy	33/2187	99/9376	1.42905044962658	ITGA5/ITGB8/PRKAG2/SNTB1/LMNA/ITGAV/IL6/ATP2A2/DES/ITGA4/EMD/TNF/TGFB1/ITGB3/ATP2A3/SLC8A2/SLC8A1/CACNA2D4/TTN/EDN1/CACNB2/CACNA1D/ITGB7/TPM4/ATP2A1/ACE/ITGA10/ITGB4/MYBPC3/TGFB2/CACNG2/TPM3/CACNB1	2.36699842169316
Human Diseases	Cancer: specific types	hsa05225	Hepatocellular carcinoma	52/2187	170/9376	1.31136394201027	CDKN1A/MAP2K1/PIK3CB/AKT3/TXNRD1/NFE2L2/GADD45A/GADD45G/GADD45B/RAF1/TCF7/GSTO2/PIK3R1/PLCG2/SMAD3/TGFB1/GSTO1/KRAS/HMOX1/NRAS/TCF7L2/WNT2B/SHC3/SMAD2/PHF10/PRKCG/MET/CTNNB1/ARID2/GRB2/MAPK1/DDB2/BRAF/RPS6KB1/AXIN1/MYC/PTEN/ELK1/SMARCD3/E2F3/APC2/GSK3B/BCL2L1/PIK3R3/CSNK1A1/PRKCB/WNT5A/TGFB2/WNT5B/WNT9A/FZD8/IGF1R	2.2596078785328
Human Diseases	Neurodegenerative disease	hsa05017	Spinocerebellar ataxia	45/2187	144/9376	1.33973479652492	ERN1/PPIF/ITPR1/PIK3CB/AKT3/ATP2A2/RB1CC1/CYCS/PIK3R1/PSMD14/PSMD12/ATG13/PSMA6/PSMD11/PSMD7/PSMB7/PSMD1/ATG101/NOP56/BECN1/AFG3L2/KCNC3/MAPK8/PRKCG/ATP2A3/KAT5/MCU/GTF2B/ATXN1/PUM1/MAP3K5/ATG2A/GNAQ/PIK3R3/XBP1/SP1/TRAF2/ATP2A1/WIPI1/PRKCB/ULK1/ATG2B/GRIN2D/RELN/MAPK10	2.2659439695713
Organismal Systems	Immune system	hsa04623	Cytosolic DNA-sensing pathway	28/2187	83/9376	1.44626792492329	IL1B/NFKBIA/NFKB1/IL18/IRF7/IL6/TBK1/ADAR/CGAS/RIPK1/GSDME/CASP1/G3BP1/NFKBIB/CASP8/RELA/DNASE2/SAMHD1/CASP3/MLKL/AIM2/POLR3C/PCBP1/POLR1C/CXCL10/MEFV/POLR3D/ZBP1	2.25233268394919
Human Diseases	Cancer: specific types	hsa05218	Melanoma	25/2187	73/9376	1.46820251673964	CDKN1A/MAP2K1/PIK3CB/AKT3/GADD45A/GADD45G/GADD45B/RAF1/MDM2/PIK3R1/KRAS/NRAS/PDGFB/MET/MAPK1/DDB2/PDGFA/BRAF/PTEN/E2F3/FGF18/PIK3R3/PDGFD/IGF1R/FGFR1	2.21492717392526
Human Diseases	Cancer: specific types	hsa05226	Gastric cancer	46/2187	150/9376	1.31472641365645	CDKN1A/BCL2/MAP2K1/PIK3CB/AKT3/GADD45A/GADD45G/GADD45B/RAF1/TCF7/PIK3R1/SMAD3/TGFB1/KRAS/CTNNA1/NRAS/TCF7L2/WNT2B/SHC3/SMAD2/CDKN2B/MET/CTNNB1/GRB2/MAPK1/DDB2/RXRA/BRAF/MLH1/RPS6KB1/JUP/AXIN1/ABCB1/MYC/E2F3/FGF18/APC2/GSK3B/PIK3R3/CSNK1A1/WNT5A/CCNE2/TGFB2/WNT5B/WNT9A/FZD8	2.14312688895048
Cellular Processes	Cell growth and death	hsa04110	Cell cycle	48/2187	158/9376	1.30242572624195	CDKN1A/CUL1/GADD45A/GADD45G/MAD1L1/GADD45B/MDM2/PPP2CA/DBF4/YWHAG/YWHAQ/SMAD3/CREBBP/FZR1/TGFB1/EP300/YWHAH/WAPL/TFDP1/STAG2/PTTG1/ZBTB17/SMAD2/YWHAZ/CDKN2B/CDC14A/WEE1/CHEK1/CDK7/MYC/PPP2R1B/ESPL1/MAD2L1BP/PPP2R5A/ESCO1/E2F3/GSK3B/NIPBL/CCND3/STAG1/SKP1/CCNE2/TGFB2/ORC1/SMC1B/CCNB2/CCNH/SGO1	2.11448550190583
Organismal Systems	Digestive system	hsa04977	Vitamin digestion and absorption	11/2187	26/9376	1.81379480144912	CUBN/TCN2/BTD/SLC19A2/APOA1/APOB/SLC19A1/MMACHC/SLC19A3/SCARB1/SLC5A6	2.29177283704676
Organismal Systems	Sensory system	hsa04750	Inflammatory mediator regulation of TRP channels	32/2187	99/9376	1.38574589054699	IL1B/MAP2K3/SRC/ITPR1/PRKCH/PIK3CB/ADCY3/MAPK13/PTGER4/IL1R1/PTGER2/PRKCE/PIK3R1/PLCG2/IL1RAP/PLA2G6/PLA2G4C/MAPK8/PRKCG/PRKCD/TRPV2/ADCY9/GNAQ/PIK3R3/CALM1/CAMK2D/PLA2G4A/PRKCB/TRPV4/HTR2B/NTRK1/MAPK10	2.12809452803048
Genetic Information Processing	Translation	hsa03015	mRNA surveillance pathway	33/2187	103/9376	1.37355334478671	PABPC4/NXF1/ETF1/PABPC1/FUS/EIF4A3/WDR33/RBM8A/PPP2CA/NXT2/SMG1/GSPT1/CPSF7/PPP2R2D/PPP2R2A/PAPOLA/RNPS1/UPF3B/PCF11/NXT1/HBS1L/SMG7/ACIN1/PPP2R3A/PPP2R3C/TARDBP/PPP2R1B/PPP2R5A/DDX19A/MSI2/PABPC1L/CPSF3/PAPOLG	2.10250433445257
Organismal Systems	Endocrine system	hsa04912	GnRH signaling pathway	30/2187	93/9376	1.38295204802572	MAP2K3/SRC/ITPR1/PTK2B/MAP2K1/ADCY3/MAPK13/ATF4/RAF1/MAP3K2/HBEGF/KRAS/PLA2G4C/NRAS/MAPK8/GRB2/CDC42/MAPK1/PRKCD/ADCY9/MAP3K4/ELK1/MAP2K4/GNAQ/CALM1/CACNA1D/CAMK2D/PLA2G4A/PRKCB/MAPK10	2.04699830681698
Metabolism	Lipid metabolism	hsa00561	Glycerolipid metabolism	22/2187	65/9376	1.4510358411593	MGLL/ALDH2/GPAT3/GLA/LPIN1/GPAT4/MOGAT1/AGPAT4/DGKD/LPL/DGKA/ALDH3A2/LPIN2/GK/TKFC/PNPLA2/AGPAT5/DGAT1/DGAT2/LIPC/PLPP1/GLYCTK	2.01254387447029
Organismal Systems	Endocrine system	hsa04915	Estrogen signaling pathway	42/2187	139/9376	1.29539824930179	BCL2/SRC/ITPR1/MAP2K1/PIK3CB/AKT3/RARA/HSPA6/ADCY3/CREB5/CTSD/HSP90AB1/MMP9/ATF4/RAF1/PIK3R1/HBEGF/HSP90AA1/FKBP4/KRAS/HSPA8/NRAS/FKBP5/SHC3/HSPA1B/GRB2/MAPK1/PRKCD/ESR1/ADCY9/GNAI3/ATF2/HSPA1A/HSPA1L/GABBR1/GNAQ/PIK3R3/CALM1/NCOA3/SP1/OPRM1/GREB1	1.93519901069598
Metabolism	Glycan biosynthesis and metabolism	hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	9/2187	21/9376	1.83735057809132	DSE/XYLT1/CHST15/CSGALNACT2/CHST11/CHST13/CHST7/CHSY1/UST	2.11870681651574
Cellular Processes	Cellular community - eukaryotes	hsa04530	Tight junction	50/2187	170/9376	1.26092686731757	TIAM1/TJP2/SRC/PRKAG2/ACTN1/EZR/MSN/ARHGEF2/MYH9/RDX/RAPGEF2/RAP2C/TUBA1C/WHAMM/MYH11/PRKCE/NEDD4L/RAB8A/PPP2CA/TUBA4A/MICALL2/YBX3/RHOA/PPP2R2D/PPP2R2A/F11R/RAB8B/ACTR3/MAPK8/HSPA4/CDC42/VASP/MYL9/CLDN1/CD1D/CLDN12/RAPGEF6/PPP2R1B/RAP1A/PRKCI/HCLS1/CLDN14/MAP3K5/CD1C/CACNA1D/TJAP1/ACTR3B/ARPC5/MAPK10/CLDN4	1.8935795882627
Metabolism	Glycan biosynthesis and metabolism	hsa00511	Other glycan degradation	8/2187	18/9376	1.90540059950211	HEXB/MANBA/NEU3/AGA/HEXA/NEU4/MAN2B2/ENGASE	2.12061240586715
Metabolism	Metabolism of other amino acids	hsa00410	beta-Alanine metabolism	12/2187	31/9376	1.65954245763087	ALDH2/UPB1/DPYD/ACOX3/ALDH3A2/DPYS/SMOX/ACOX1/GADL1/AOC3/CNDP1/ABAT	2.02866221450936
Environmental Information Processing	Signal transduction	hsa04371	Apelin signaling pathway	42/2187	140/9376	1.28614540466392	PIK3R5/SPHK1/MRAS/ITPR1/PRKAG2/MAP2K1/AKT3/ADCY3/SLC9A1/MAP1LC3B/PRKCE/RAF1/SERPINE1/GNA13/SMAD3/MEF2D/ADCY10/KRAS/GNB1/NRAS/PIK3R6/BECN1/SMAD2/HDAC4/GNB4/MAPK1/JAG1/GNGT2/RPS6KB1/GNG4/ACTA2/ADCY9/SLC8A2/SLC8A1/GNAI3/GNAQ/MAP1LC3B2/MYLK3/CALM1/GNG7/GNG5/GNB5	1.88141507446842
Organismal Systems	Excretory system	hsa04966	Collecting duct acid secretion	11/2187	28/9376	1.68423802991704	CA2/ATP6V1A/ATP6V0D1/ATP6V1B2/ATP6V1C1/ATP6V1E1/SLC12A7/TCIRG1/ATP6V1F/ATP6V0D2/ATP6V1E2	1.9998741200062
Metabolism	Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	13/2187	35/9376	1.59237050101248	PFKFB3/HK2/FBP1/HK1/PFKP/GMDS/TPI1/PMM2/PFKFB4/TKFC/ALDOB/ALDOC/HK3	1.93645115733761
Organismal Systems	Endocrine system	hsa04926	Relaxin signaling pathway	39/2187	130/9376	1.28614540466392	VEGFA/NFKBIA/SRC/NFKB1/MAP2K1/PIK3CB/AKT3/ADCY3/CREB5/MAPK13/MMP9/ATF4/RAF1/PIK3R1/TGFB1/KRAS/RELA/GNB1/NRAS/GNA15/SHC3/SMAD2/MAPK8/GRB2/GNB4/MAPK1/GNGT2/GNG4/ACTA2/ADCY9/GNAI3/ATF2/MAP2K4/EDN1/PIK3R3/GNG7/GNG5/GNB5/MAPK10	1.81199625307179
Environmental Information Processing	Signal transduction	hsa04390	Hippo signaling pathway	46/2187	157/9376	1.25610803852528	TP53BP2/SMAD7/BIRC3/ID2/BIRC2/LATS2/TCF7/SERPINE1/PPP2CA/YWHAG/YWHAQ/SMAD3/SAV1/TGFB1/YWHAH/AREG/CSNK1D/PPP2R2D/PPP2R2A/CTNNA1/TCF7L2/WNT2B/MOB1A/SMAD2/YWHAZ/MOB1B/CTNNB1/AXIN1/BMP6/MYC/PPP2R1B/PRKCI/NKD1/BMP8A/APC2/GSK3B/FRMD6/ITGB2/CCND3/WNT5A/TGFB2/WNT5B/WNT9A/BMP2/FZD8/BMPR1B	1.78487134231538
Organismal Systems	Circulatory system	hsa04261	Adrenergic signaling in cardiomyocytes	45/2187	154/9376	1.25273903051681	PIK3R5/BCL2/AKT3/ADCY3/CREB5/ATP2B1/SLC9A1/ATP1A1/MAPK13/ATP2A2/ATF4/PPP2CA/ADRB2/KCNE1/POPDC2/PPP2R2D/PPP2R2A/PIK3R6/PPP2R3A/PPP2R3C/MAPK1/ATP2A3/ADCY9/SLC8A2/SLC8A1/GNAI3/ATF2/CACNA2D4/ATP1B3/PPP2R1B/PPP2R5A/CACNB2/GNAQ/CALM1/CACNA1D/CAMK2D/TPM4/ATP2A1/RAPGEF4/PLN/CACNG2/TPM3/ATP1B2/CACNB1/FXYD2	1.74419848381668
Metabolism	Glycan biosynthesis and metabolism	hsa00531	Glycosaminoglycan degradation	8/2187	19/9376	1.80511635742305	IDS/HPSE/GNS/HEXB/GUSB/ARSB/HEXA/GALNS	1.93750541016507
Human Diseases	Cardiovascular disease	hsa05414	Dilated cardiomyopathy	32/2187	105/9376	1.30656041108716	ITGA5/ITGB8/SNTB1/LMNA/ITGAV/ADCY3/ATP2A2/DES/ITGA4/EMD/TNF/TGFB1/ITGB3/ATP2A3/ADCY9/SLC8A2/SLC8A1/CACNA2D4/TTN/CACNB2/CACNA1D/ITGB7/TPM4/ATP2A1/ITGA10/ITGB4/MYBPC3/PLN/TGFB2/CACNG2/TPM3/CACNB1	1.74230112354307
Environmental Information Processing	Signal transduction	hsa04070	Phosphatidylinositol signaling system	30/2187	98/9376	1.31239327006523	ITPR1/PIK3CB/SYNJ2/INPP5A/ITPK1/MTMR3/PIK3R1/PLCG2/PI4K2A/ITPKC/DGKD/DGKA/PRKCG/PI4KB/INPP1/PIP5K1A/PI4K2B/PIP5K1C/INPPL1/IMPA2/MTMR14/IMPA1/IPPK/PTEN/INPP5F/PIK3R3/MTMR8/CALM1/PRKCB/PLCD1	1.71460194049809
Organismal Systems	Endocrine system	hsa04929	GnRH secretion	21/2187	65/9376	1.38507966656115	ITPR1/MAP2K1/PIK3CB/AKT3/RAF1/PIK3R1/KRAS/KCNN4/NRAS/PRKCG/MAPK1/CACNA1G/GABBR1/KCNN1/GNAQ/PIK3R3/CACNA1D/HCN2/PRKCB/TRPC4/KCNN3	1.71824421342824
Human Diseases	Infectious disease: bacterial	hsa05110	Vibrio cholerae infection	17/2187	51/9376	1.42905044962658	TJP2/ATP6V1H/ADCY3/SLC12A2/ERO1A/PLCG2/ATP6V1A/ATP6V0D1/ATP6V1B2/ATP6V1C1/ATP6V1E1/ARF1/TCIRG1/ADCY9/ATP6V1F/ATP6V0D2/ATP6V1E2	1.69451265717577
Human Diseases	Drug resistance: antineoplastic	hsa01523	Antifolate resistance	11/2187	30/9376	1.57195549458924	IL1B/NFKB1/IL6/ABCC3/TNF/FPGS/RELA/GART/GGH/SLC19A1/ABCC2	1.73055642228331
Organismal Systems	Circulatory system	hsa04270	Vascular smooth muscle contraction	39/2187	134/9376	1.2477530045247	KCNMA1/ADM/ITPR1/PRKCH/MAP2K1/GNA12/ADCY3/MYH9/ADORA2A/ACTG2/MYH11/PRKCE/RAF1/ADORA2B/GNA13/RHOA/KCNMB1/PLA2G6/PLA2G4C/KCNMB4/PRKCG/MAPK1/PRKCD/BRAF/MYL9/ACTA2/ADCY9/CALCRL/RAMP1/EDN1/GNAQ/PPP1R12A/MYLK3/CALM1/CACNA1D/PLA2G4A/PRKCB/RAMP3/PTGIR	1.59317739201382
Organismal Systems	Nervous system	hsa04725	Cholinergic synapse	34/2187	115/9376	1.26750561619053	PIK3R5/BCL2/ITPR1/MAP2K1/PIK3CB/AKT3/ADCY3/CREB5/ATF4/PIK3R1/FYN/KRAS/GNB1/NRAS/PIK3R6/PRKCG/GNB4/MAPK1/GNGT2/GNG4/ADCY9/GNAI3/KCNQ3/ACHE/GNAQ/PIK3R3/CACNA1D/CAMK2D/GNG7/PRKCB/GNG5/CHRFAM7A/GNB5/KCNJ2	1.59194723989025
Metabolism	Lipid metabolism	hsa00564	Glycerophospholipid metabolism	31/2187	104/9376	1.27790088283915	SGMS2/GPCPD1/LPCAT1/GPAT3/SAMD8/PTDSS1/LPIN1/GPAT4/PISD/AGPAT4/CHKA/PLA2G6/PGS1/DGKD/PLA2G4C/DGKA/LPIN2/PLA1A/MBOAT7/GPD2/PCYT1A/CHPT1/LPCAT3/ACHE/SELENOI/PLD3/AGPAT5/PLA2G4A/PLPP1/GDPD5/PNPLA7	1.57179416621404
Metabolism	Carbohydrate metabolism	hsa00562	Inositol phosphate metabolism	24/2187	78/9376	1.319123491963	PIK3CB/SYNJ2/INPP5A/ITPK1/MTMR3/PLCG2/PI4K2A/TPI1/ITPKC/PI4KB/INPP1/PIP5K1A/PI4K2B/PIP5K1C/INPPL1/IMPA2/MTMR14/IMPA1/IPPK/INPP5K/PTEN/INPP5F/MTMR8/PLCD1	1.56094317748619
Human Diseases	Infectious disease: bacterial	hsa05100	Bacterial invasion of epithelial cells	24/2187	78/9376	1.319123491963	ITGA5/ARHGAP10/SRC/PIK3CB/SEPTIN6/PIK3R1/FN1/RHOA/CTNNA1/SEPTIN9/SHC3/ACTR3/MET/CTNNB1/CDC42/VCL/CBL/CD2AP/DNM2/HCLS1/PIK3R3/ACTR3B/DNM3/ARPC5	1.56094317748619
Human Diseases	Endocrine and metabolic disease	hsa04934	Cushing syndrome	44/2187	155/9376	1.21699780226264	CDKN1A/AHR/ITPR1/MAP2K1/NR4A1/ADCY3/CREB5/ATF4/TCF7/LDLR/PDE8A/FH/RASD1/TCF7L2/WNT2B/CDKN2B/RAP1B/CTNNB1/MAPK1/NCEH1/BRAF/AXIN1/ADCY9/RBBP5/GNAI3/USP8/ATF2/CACNA1G/RAP1A/E2F3/ARMC5/APC2/GSK3B/CRH/GNAQ/CACNA1D/CAMK2D/SP1/WNT5A/CCNE2/SCARB1/WNT5B/WNT9A/FZD8	1.50247744571157
Organismal Systems	Nervous system	hsa04720	Long-term potentiation	21/2187	67/9376	1.34373400487276	ITPR1/MAP2K1/RPS6KA3/ATF4/RAF1/CREBBP/PPP3CC/EP300/KRAS/NRAS/PRKCG/RAP1B/MAPK1/BRAF/RPS6KA2/RAP1A/GNAQ/CALM1/CAMK2D/PRKCB/GRIN2D	1.55734263092444
Human Diseases	Neurodegenerative disease	hsa05022	Pathways of neurodegeneration - multiple diseases	125/2187	480/9376	1.11644566377077	IL1B/ERN1/MAP2K3/PTGS2/BCL2/PPIF/IL1A/UBC/NFKB1/ITPR1/CAPN2/TUBB6/EIF2AK3/MAP2K1/TUBB4B/BID/HSPA5/DDIT3/IL6/DNAH17/PSEN1/MAPK13/TBK1/ATP2A2/MAP1LC3B/TUBA1C/CHMP2B/ATF4/RB1CC1/RAB5A/FUS/CYCS/TANK/RAF1/PPID/DNAI2/PSMD14/RAB8A/PSMD12/TNF/UBE2J1/ATG13/C9orf72/PSMA6/PSMD11/TUBA4A/FAS/PPP3CC/PSMD7/PRNP/KRAS/UQCRC2/CASP8/UBE2L6/RELA/PSMB7/UBA1/DERL1/PSMD1/SQSTM1/ZFYVE1/ATG101/GPX3/NRAS/TNFRSF1B/WNT2B/BECN1/KIF5B/APP/MAPK8/PRKCG/ACTR1B/CTNNB1/SDHB/VAPB/MAPK1/EIF2S1/ATP2A3/BRAF/TARDBP/HIP1/MCU/CASP3/UBE2G1/AXIN1/MFN1/LRRK2/SLC6A3/ATXN1/APC2/GSK3B/BCL2L1/DNAH3/MAP3K5/ATG2A/GNAQ/RAB1A/MAP1LC3B2/CALM1/CACNA1D/CSNK1A1/CAMK2D/UQCRHL/XBP1/TOMM40L/TRAF2/ATP2A1/WIPI1/DKK1/PRKCB/MT-ATP8/CASP9/WNT5A/ULK1/CHRFAM7A/ATG2B/GRIN2D/ATF6/DNAH11/DNAH12/WNT5B/MAPK10/WNT9A/FZD8/DNAH2	1.44451594573433
Organismal Systems	Nervous system	hsa04730	Long-term depression	19/2187	60/9376	1.35759792714525	ITPR1/MAP2K1/GNA12/RAF1/PPP2CA/GNA13/KRAS/PLA2G4C/NRAS/PRKCG/MAPK1/BRAF/GNAI3/PPP2R1B/CRH/GNAQ/PLA2G4A/PRKCB/IGF1R	1.53261003863531
Organismal Systems	Endocrine system	hsa04918	Thyroid hormone synthesis	23/2187	75/9376	1.31472641365645	ALB/ITPR1/HSPA5/ADCY3/CREB5/ATP1A1/ATF4/CANX/GPX3/ASGR1/PRKCG/PAX8/DUOX1/ADCY9/ATF2/ATP1B3/TG/GNAQ/TTF2/PRKCB/TTR/ATP1B2/FXYD2	1.50929728342717
Organismal Systems	Digestive system	hsa04972	Pancreatic secretion	30/2187	102/9376	1.26092686731757	KCNMA1/ITPR1/CA2/ADCY3/ATP2B1/SLC12A2/SLC9A1/ATP1A1/ATP2A2/RAB8A/CD38/RHOA/TPCN2/PRKCG/RAP1B/BST1/ATP2A3/ADCY9/ATP1B3/RAP1A/RAB11A/GNAQ/CPB1/CPB2/ATP2A1/PRKCB/SLC26A3/CELA2B/ATP1B2/FXYD2	1.46137316497542
Human Diseases	Endocrine and metabolic disease	hsa04932	Non-alcoholic fatty liver disease	44/2187	157/9376	1.20149464554592	IL1B/ERN1/IL1A/NFKB1/PRKAG2/IL6R/EIF2AK3/PIK3CB/CXCL8/AKT3/BID/DDIT3/IL6/MAPK13/ATF4/CYCS/ADIPOR2/BCL2L11/IRS2/PIK3R1/TNF/FAS/TGFB1/UQCRC2/CASP8/RELA/PPARG/SREBF1/MAPK8/SDHB/CDC42/GSK3A/EIF2S1/RXRA/CASP3/NR1H3/INSR/GSK3B/MAP3K5/PIK3R3/UQCRHL/XBP1/TRAF2/MAPK10	1.40425900153621
Organismal Systems	Endocrine system	hsa04921	Oxytocin signaling pathway	43/2187	154/9376	1.19706174027162	CDKN1A/PTGS2/PIK3R5/SRC/ITPR1/PRKAG2/MAP2K1/CAMK1D/ADCY3/NFATC1/RGS2/RAF1/CAMKK2/PPP3CC/CD38/KRAS/RHOA/CAMK1/PLA2G4C/NRAS/PIK3R6/PRKCG/MAPK1/MYL9/ADCY9/OXTR/GNAI3/CACNA2D4/ELK1/CACNB2/GNAQ/CAMK1G/EEF2/PPP1R12A/MYLK3/CALM1/CACNA1D/CAMK2D/PLA2G4A/PRKCB/CACNG2/CACNB1/KCNJ2	1.35995927458134
Metabolism	Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	12/2187	36/9376	1.42905044962658	HK2/MGAM/HK1/GBE1/GYS1/GYG1/PYGB/UGP2/PYGM/HK3/TREH/PGM2L1	1.42253172792602
Metabolism	Glycan biosynthesis and metabolism	hsa00512	Mucin type O-glycan biosynthesis	12/2187	36/9376	1.42905044962658	B4GALT5/ST3GAL1/GALNT6/GALNT2/GCNT4/GALNT4/GALNT7/GALNT15/ST6GALNAC2/ST6GALNAC3/GALNT3/GALNT18	1.42253172792602
Organismal Systems	Development and regeneration	hsa04360	Axon guidance	50/2187	184/9376	1.16498677958689	CXCR4/SEMA4A/PLXNC1/SEMA6B/SRC/PIK3CB/SSH1/EPHB2/SEMA3C/PAK1/SEMA4D/RAF1/PIK3R1/FYN/DPYSL2/PLCG2/PPP3CC/KRAS/RHOA/NRAS/LIMK1/UNC5B/PTPN11/PDPK1/MET/EFNA2/CDC42/MAPK1/MYL9/GNAI3/EPHB6/PLXNA1/CXCL12/GSK3B/PIK3R3/NTN1/CAMK2D/SEMA3A/RND1/ROBO3/WNT5A/SSH2/SEMA4C/SEMA7A/WNT5B/BOC/TRPC4/BMPR1B/EFNA1/EPHB1	1.24660492146917
Organismal Systems	Nervous system	hsa04728	Dopaminergic synapse	37/2187	133/9376	1.19266616472594	ITPR1/AKT3/CREB5/GNAL/MAPK13/ATF4/PPP2CA/PPP3CC/PPP2R2D/PPP2R2A/GNB1/KIF5B/MAPK8/PRKCG/PPP2R3A/PPP2R3C/GSK3A/GNB4/GNGT2/GNG4/GNAI3/ATF2/PPP2R1B/PPP2R5A/SLC6A3/GSK3B/GNAQ/CALM1/CACNA1D/CAMK2D/GNG7/MAOB/PRKCB/GNG5/GNB5/MAPK10/MAOA	1.23424274803421
Organismal Systems	Digestive system	hsa04973	Carbohydrate digestion and absorption	15/2187	48/9376	1.33973479652492	HK2/PIK3CB/AKT3/ATP1A1/MGAM/PIK3R1/SLC2A5/HK1/ATP1B3/HK3/PIK3R3/CACNA1D/PRKCB/ATP1B2/FXYD2	1.30149399490987
Human Diseases	Infectious disease: parasitic	hsa05143	African trypanosomiasis	12/2187	37/9376	1.39042746450154	IL1B/IL18/IL6/IL10/TNF/FAS/MYD88/ICAM1/APOA1/PRKCG/GNAQ/PRKCB	1.31240181591128
Organismal Systems	Endocrine system	hsa04925	Aldosterone synthesis and secretion	28/2187	98/9376	1.22490038539421	ITPR1/CAMK1D/NR4A1/ADCY3/CREB5/ATP2B1/ATP1A1/ATF4/PRKCE/PDE2A/LDLR/CAMK1/ATF1/PRKCG/DAGLA/ADCY9/DAGLB/ATF2/ATP1B3/CACNA1G/GNAQ/CAMK1G/CALM1/CACNA1D/CAMK2D/PRKCB/SCARB1/ATP1B2	1.23438842691832
Human Diseases	Neurodegenerative disease	hsa05010	Alzheimer disease	100/2187	388/9376	1.10493591465973	IL1B/ERN1/PTGS2/PPIF/IL1A/NFKB1/ITPR1/CAPN2/TUBB6/EIF2AK3/MAP2K1/PIK3CB/AKT3/TUBB4B/BID/EIF2AK2/DDIT3/IL6/PSEN1/ADAM17/ATP2A2/TUBA1C/ATF4/RB1CC1/SLC39A10/CYCS/RAF1/IRS2/PPID/SLC39A8/PIK3R1/PSMD14/PSMD12/TNF/APOE/ATG13/PSMA6/PSMD11/TUBA4A/FAS/PPP3CC/PSMD7/KRAS/UQCRC2/CASP8/RELA/PSMB7/PSMD1/ATG101/LPL/NRAS/WNT2B/BECN1/KIF5B/APP/MAPK8/CTNNB1/SDHB/SLC39A9/RTN4/MAPK1/EIF2S1/RTN3/ATP2A3/BRAF/MCU/CASP3/AXIN1/SLC11A2/SLC39A11/INSR/APC2/SLC39A14/GSK3B/MAP3K5/ATG2A/GNAQ/PIK3R3/CALM1/CACNA1D/CSNK1A1/UQCRHL/XBP1/TRAF2/ATP2A1/WIPI1/DKK1/MT-ATP8/CASP9/MME/WNT5A/ULK1/CHRFAM7A/ATG2B/GRIN2D/ATF6/WNT5B/MAPK10/WNT9A/FZD8	1.16435194015552
Organismal Systems	Nervous system	hsa04721	Synaptic vesicle cycle	23/2187	79/9376	1.24815798764853	STX3/ATP6V1H/SLC1A3/NAPA/ATP6V1A/ATP6V0D1/ATP6V1B2/SLC1A2/ATP6V1C1/ATP6V1E1/TCIRG1/ATP6V1F/DNM2/SLC6A3/CPLX1/ATP6V0D2/ATP6V1E2/STX1B/DNM3/UNC13B/SLC6A7/SLC6A12/RAB3A	1.22164824886755
Environmental Information Processing	Membrane transport	hsa02010	ABC transporters	14/2187	45/9376	1.33378041965148	ABCG1/ABCC3/ABCA1/TAP1/TAP2/ABCA13/DEFB1/ABCB4/ABCA5/ABCB1/ABCD1/ABCC6/ABCA10/ABCC2	1.23788074161995
Organismal Systems	Environmental adaptation	hsa04710	Circadian rhythm	11/2187	34/9376	1.38701955404933	BHLHE40/NFIL3/PRKAG2/CUL1/CSNK1D/RORB/PER1/CRY1/SKP1/NR1D1/CRY2	1.24689023313644
Organismal Systems	Nervous system	hsa04726	Serotonergic synapse	32/2187	115/9376	1.19294646229697	PTGS2/ITPR1/MAP2K1/RAF1/KRAS/HTR7/GNB1/PTGS1/PLA2G4C/NRAS/APP/PRKCG/GNB4/MAPK1/BRAF/GNGT2/GNG4/CASP3/GNAI3/GNAQ/CACNA1D/GNG7/MAOB/PLA2G4A/PRKCB/GNG5/ALOX5/HTR2B/DUSP1/GNB5/ALOX15B/MAOA	1.14823977333424
Organismal Systems	Excretory system	hsa04961	Endocrine and other factor-regulated calcium reabsorption	16/2187	53/9376	1.29423436947313	VDR/ATP2B1/ATP1A1/PRKCG/ESR1/ADCY9/SLC8A2/SLC8A1/ATP1B3/DNM2/RAB11A/GNAQ/PRKCB/DNM3/ATP1B2/FXYD2	1.18475699583652
Metabolism	Amino acid metabolism	hsa00380	Tryptophan metabolism	13/2187	42/9376	1.3269754175104	KMO/KYNU/IL4I1/ALDH2/ACAT2/CYP1B1/ALDH3A2/DLST/AFMID/MAOB/AANAT/KYAT1/MAOA	1.17133639559606
Metabolism	Glycan biosynthesis and metabolism	hsa00541	Biosynthesis of various nucleotide sugars	7/2187	20/9376	1.50050297210791	UAP1/CYB5R4/GMDS/NANS/GNE/UGP2/NANP	1.23581180636935
Cellular Processes	Cellular community - eukaryotes	hsa04550	Signaling pathways regulating pluripotency of stem cells	39/2187	144/9376	1.1611034903216	JARID2/MAP2K1/PIK3CB/SKIL/AKT3/INHBA/PCGF5/ID2/JAK1/MAPK13/RAF1/TCF7/PIK3R1/SMAD3/KRAS/ACVR1/NRAS/WNT2B/SMAD2/CTNNB1/RIF1/GRB2/MAPK1/AXIN1/MYC/LIF/ACVR1B/APC2/GSK3B/PIK3R3/STAT3/WNT5A/HESX1/WNT5B/WNT9A/FZD8/BMPR1B/IGF1R/FGFR1	1.07451896627944
Human Diseases	Neurodegenerative disease	hsa05014	Amyotrophic lateral sclerosis	94/2187	368/9376	1.09508757281167	ERN1/MAP2K3/BCL2/TUBB6/EIF2AK3/NXF1/TUBB4B/BID/HSPA5/DDIT3/DNAH17/MAPK13/TBK1/MAP1LC3B/TUBA1C/CHMP2B/ATF4/RB1CC1/RAB5A/FUS/CYCS/TANK/DNAI2/PSMD14/RAB8A/PSMD12/TNF/ATG13/C9orf72/NUP98/NXT2/PSMA6/PSMD11/UBQLN1/TUBA4A/PPP3CC/CASP1/PSMD7/NUP58/NUP210L/UQCRC2/PSMB7/DERL1/PSMD1/SLC1A2/NUP153/SQSTM1/NUP188/ATG101/GPX3/TNFRSF1B/BECN1/KIF5B/NXT1/ACTR1B/NUP62/SRSF3/SDHB/VAPB/EIF2S1/HNRNPA3/HNRNPA2B1/TARDBP/MCU/CASP3/ANG/RANBP2/NUP50/SETX/BCL2L1/DNAH3/MAP3K5/ATG2A/RAB1A/NUP210/HNRNPA1/MAP1LC3B2/MATR3/UQCRHL/XBP1/TOMM40L/TRAF2/WIPI1/MT-ATP8/CASP9/ULK1/ATG2B/GRIN2D/ATF6/HDAC6/DNAH11/DNAH12/SRSF7/DNAH2	1.02638257486846
Environmental Information Processing	Signaling molecules and interaction	hsa04512	ECM-receptor interaction	25/2187	89/9376	1.20425599687633	ITGA5/CD44/ITGB8/SDC4/ITGAV/THBS1/ITGA4/FN1/LAMB3/VWF/TNC/GP6/ITGB3/AGRN/ITGB7/MEPE/SV2C/HMMR/ITGA10/ITGB4/LAMA3/RELN/COL9A2/THBS3/LAMB1	1.06784417895896
Cellular Processes	Cellular community - eukaryotes	hsa04540	Gap junction	25/2187	89/9376	1.20425599687633	SRC/ITPR1/TUBB6/MAP2K1/TUBB4B/ADCY3/TUBA1C/RAF1/MAP3K2/TUBA4A/KRAS/CSNK1D/NRAS/PDGFB/PRKCG/GRB2/MAPK1/PDGFA/ADCY9/GNAI3/GNAQ/PRKCB/HTR2B/PDGFD/LPAR1	1.06784417895896
Organismal Systems	Nervous system	hsa04727	GABAergic synapse	25/2187	89/9376	1.20425599687633	SRC/GLS/GABARAPL1/ADCY3/GLUL/SLC38A2/GNB1/PRKCG/GNB4/GNGT2/GNG4/ADCY9/GNAI3/GABBR1/SLC38A1/CACNA1D/GNG7/GABRR2/PRKCB/GNG5/ABAT/PLCL1/GNB5/GPHN/SLC6A12	1.06784417895896
NA	NA	hsa03273	Virion - Lassa virus and SFTS virus	6/2187	17/9376	1.51311224078109	MYH9/MYH11/NRP2/LAMP2/TFRC/PCDH9	1.16787913695551
Human Diseases	Cancer: specific types	hsa05217	Basal cell carcinoma	18/2187	63/9376	1.22490038539421	CDKN1A/GADD45A/GADD45G/GADD45B/PTCH2/TCF7/TCF7L2/WNT2B/CTNNB1/DDB2/AXIN1/APC2/GSK3B/WNT5A/WNT5B/WNT9A/BMP2/FZD8	0.98785103865553
Metabolism	Metabolism of cofactors and vitamins	hsa00770	Pantothenate and CoA biosynthesis	7/2187	21/9376	1.42905044962658	ALDH2/BCAT1/UPB1/DPYD/ALDH3A2/DPYS/GADL1	1.08560516471494
Metabolism	Glycan biosynthesis and metabolism	hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/2187	14/9376	1.53112548174277	B3GNT2/ST3GAL1/B4GALT1/B3GNT7/CHST2	1.096863602373
NA	NA	hsa03272	Virion - Hepatitis viruses	14/2187	48/9376	1.25041914342326	CHMP4B/CHMP1B/LDLR/LAMP2/IST1/VPS4B/PDCD6IP/CHMP1A/CLDN1/SLC10A1/CLDN12/CLDN14/SCARB1/CLDN4	0.95933361760292
Environmental Information Processing	Signal transduction	hsa04020	Calcium signaling pathway	65/2187	254/9376	1.09710566014639	CXCR4/VEGFA/PPIF/SPHK1/ITPR1/PTK2B/CAMK1D/ADCY3/NFATC1/ADORA2A/ATP2B1/GNAL/ATP2A2/P2RX4/P2RX7/ORAI2/ADORA2B/PLCG2/ADRB2/PPP3CC/CD38/CAMK1/HTR7/ITPKC/P2RX1/GNA15/TPCN2/TFEB/PDGFB/PRKCG/MET/ATP2A3/PDGFA/MCOLN2/MCU/ADCY9/OXTR/SLC8A2/SLC8A1/STIM2/CACNA1G/PDE1B/FGF18/PHKA2/GNAQ/CAMK1G/NTRK3/MYLK3/CALM1/CACNA1D/CAMK2D/PTGER3/ATP2A1/PRKCB/NTSR1/CYSLTR2/FLT4/PLCD1/CHRFAM7A/PLN/HTR2B/GRIN2D/PDGFD/NTRK1/FGFR1	0.865350715901271
Environmental Information Processing	Signal transduction	hsa04340	Hedgehog signaling pathway	16/2187	56/9376	1.22490038539421	BCL2/CUL1/PTCH2/CUL3/CSNK1D/SMURF1/SPOPL/SMURF2/GPR161/CSNK1G1/IQCE/SCUBE2/GSK3B/CSNK1A1/HHAT/BOC	0.931005067544568
Metabolism	Lipid metabolism	hsa00061	Fatty acid biosynthesis	6/2187	18/9376	1.42905044962658	ACSL5/ACSL3/ACSL1/ACSL4/OXSM/ACACB	1.00491396484754
Metabolism	Global and overview maps	hsa01250	Biosynthesis of nucleotide sugars	11/2187	37/9376	1.27455850912641	UAP1/HK2/HK1/GMDS/PMM2/NANS/GFPT1/GNE/UGP2/HK3/NANP	0.922914289371089
Metabolism	Global and overview maps	hsa01212	Fatty acid metabolism	16/2187	57/9376	1.2034109049487	ELOVL5/ELOVL7/ACSL5/ACSL3/ACAT2/ACSL1/PPT1/ACSL4/SCD/ACOX3/ACAA2/CPT1A/OXSM/ACOX1/CPT1B/HACD1	0.849577088548428
Organismal Systems	Endocrine system	hsa04916	Melanogenesis	27/2187	101/9376	1.14607016257181	MAP2K1/ADCY3/RAF1/TCF7/CREBBP/EP300/KRAS/NRAS/TCF7L2/WNT2B/PRKCG/CTNNB1/MAPK1/ADCY9/GNAI3/ASIP/EDN1/GSK3B/GNAQ/CALM1/CAMK2D/PRKCB/WNT5A/MC1R/WNT5B/WNT9A/FZD8	0.814031157895289
Metabolism	Carbohydrate metabolism	hsa00520	Amino sugar and nucleotide sugar metabolism	11/2187	38/9376	1.24101749572835	UAP1/HK2/HEXB/HK1/PMM2/GNPDA1/HEXA/GFPT1/GNE/UGP2/HK3	0.821087084927388
Metabolism	Metabolism of cofactors and vitamins	hsa00760	Nicotinate and nicotinamide metabolism	11/2187	38/9376	1.24101749572835	PNP/SIRT1/CD38/NT5C2/NAMPT/SIRT7/NT5E/BST1/NADK/SARM1/NUDT13	0.821087084927388
Human Diseases	Cancer: overview	hsa05207	Chemical carcinogenesis - receptor activation	55/2187	217/9376	1.08660518059164	VEGFA/AHR/BCL2/SRC/NFKB1/MAP2K1/PIK3CB/AKT3/VDR/RPS6KA3/ADCY3/NOTCH2/CREB5/HSP90AB1/ATF4/STAT5A/RAF1/KPNA4/GSTO2/PIK3R1/BCL6/CYP1B1/HSP90AA1/KPNA2/ADRB2/GSTO1/KRAS/RELA/KLF5/NRAS/PRKCG/GRB2/PTGES3/MAPK1/JAG1/RXRA/RPS6KB1/ESR1/ADCY9/GNAI3/RPS6KA2/ATF2/MYC/DLL1/STAT5B/FGF18/PIK3R3/STAT3/CACNA1D/CCND3/PRKCB/AR/CHRFAM7A/NR1I3/EPHX3	0.711910661549868
Metabolism	Amino acid metabolism	hsa00270	Cysteine and methionine metabolism	15/2187	54/9376	1.19087537468882	SDS/IL4I1/GCLC/SDSL/BCAT1/MAT2A/GCLM/LACC1/LDHA/SMS/AHCYL1/AMD1/LDHC/CTH/KYAT1	0.775832594074342
Organismal Systems	Digestive system	hsa04974	Protein digestion and absorption	27/2187	103/9376	1.12381637300731	SLC36A4/ATP1A1/SLC38A2/SLC3A2/SLC36A3/COL18A1/KCNN4/COL23A1/SLC1A5/SLC8A2/SLC8A1/SLC7A7/ATP1B3/COL13A1/KCNK5/COL24A1/COL12A1/CPB1/COL7A1/CPB2/MME/SLC16A10/CELA2B/ATP1B2/COL9A2/SLC7A8/FXYD2	0.696886976270296
Organismal Systems	Endocrine system	hsa04614	Renin-angiotensin system	7/2187	23/9376	1.30478519313731	ANPEP/CTSA/PREP/MAS1/ACE/MME/REN	0.807157159529892
Organismal Systems	Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	7/2187	23/9376	1.30478519313731	CA2/GLS/ATP1A1/GLUD1/ATP1B3/ATP1B2/FXYD2	0.807157159529892
Human Diseases	Infectious disease: bacterial	hsa05150	Staphylococcus aureus infection	26/2187	99/9376	1.12591853606943	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/FPR3/HLA-DMA/C3/HLA-DRA/FCGR2B/HLA-DOA/HLA-DMB/C5AR1/HLA-DQB2/IL10/ICAM1/CFH/FPR1/DEFB1/FCGR2A/ITGB2/ITGAM/DEFA3/CAMP	0.69467116605437
Human Diseases	Substance dependence	hsa05032	Morphine addiction	24/2187	91/9376	1.13067727882543	ADCY3/PDE7A/PDE4A/PDE2A/PDE4B/PDE8A/GRK6/GNB1/PDE4C/PRKCG/GNB4/GNGT2/GNG4/ADCY9/GNAI3/GABBR1/PDE1B/GNG7/GABRR2/PRKCB/GNG5/OPRM1/GNB5/GRK4	0.690884759232812
Metabolism	Lipid metabolism	hsa01040	Biosynthesis of unsaturated fatty acids	8/2187	27/9376	1.27026706633474	ELOVL5/ELOVL7/SCD/ACOX3/ACOT7/ACOX1/BAAT/HACD1	0.775654323572137
Metabolism	Lipid metabolism	hsa00071	Fatty acid degradation	12/2187	43/9376	1.19641432991993	ACSL5/ALDH2/ACSL3/ACAT2/ACSL1/ACSL4/ACOX3/ACAA2/ALDH3A2/CPT1A/ACOX1/CPT1B	0.711987800773985
Metabolism	Glycan biosynthesis and metabolism	hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	5/2187	16/9376	1.33973479652492	GLA/ST3GAL1/HEXB/HEXA/A3GALT2	0.750132333530351
Cellular Processes	Cell growth and death	hsa04114	Oocyte meiosis	35/2187	138/9376	1.08732099428109	ITPR1/MAP2K1/RPS6KA3/CUL1/ADCY3/MAD1L1/MAPK13/PPP2CA/YWHAG/YWHAQ/SLK/PPP3CC/CPEB2/YWHAH/PTTG1/REC8/YWHAZ/MAPK1/ADCY9/RPS6KA2/PPP2R1B/ESPL1/PPP2R5A/CALM1/CAMK2D/SPDYA/SKP1/CCNE2/AR/AURKA/SMC1B/CCNB2/SPDYE2/SGO1/IGF1R	0.569960848485752
Metabolism	Lipid metabolism	hsa00100	Steroid biosynthesis	6/2187	20/9376	1.28614540466392	SOAT1/CYP51A1/LSS/LIPA/SC5D/HSD17B7	0.706533006053299
Human Diseases	Infectious disease: viral	hsa05171	Coronavirus disease - COVID-19	59/2187	238/9376	1.0627812167391	IL1B/TRAF3/MX1/MX2/C3/NFKBIA/NFKB1/IL6R/PIK3CB/CXCL8/IFIH1/OAS2/STAT1/C5AR1/EIF2AK2/TAB2/IL6/IRAK1/JAK1/MAPK13/TBK1/ADAM17/ADAR/CSF2/OAS3/CGAS/CSF3/ISG15/PIK3R1/TNF/HBEGF/PLCG2/CASP1/NFKBIB/MYD88/RELA/IFNAR2/IRF9/RPS4Y1/VWF/IFNAR1/MAPK8/PRKCG/OAS1/STAT2/MAPK1/RPS10-NUDT3/TRAF6/TLR2/FCGR2A/MAS1/PIK3R3/STAT3/RPS26/CXCL10/PRKCB/ACE/MAPK10/RPS20	0.541088642222343
Organismal Systems	Endocrine system	hsa04913	Ovarian steroidogenesis	14/2187	52/9376	1.15423305546762	PTGS2/ADCY3/CYP1B1/LDLR/PLA2G4C/ADCY9/BMP6/INSR/AKR1C3/PLA2G4A/ALOX5/SCARB1/HSD17B7/IGF1R	0.61511141938487
Metabolism	Carbohydrate metabolism	hsa00052	Galactose metabolism	9/2187	32/9376	1.20576131687243	HK2/MGAM/GLA/HK1/PFKP/B4GALT1/GALM/UGP2/HK3	0.643054960821449
Organismal Systems	Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	28/2187	110/9376	1.09127488880575	MAP2K1/PIK3CB/AKT3/STK10/RPS6KA3/ADCY3/MAD1L1/HSP90AB1/MAPK13/RAF1/PIK3R1/HSP90AA1/FZR1/CPEB2/KRAS/MAPK8/MAPK1/BRAF/ADCY9/GNAI3/RPS6KA2/PIK3R3/SPDYA/AURKA/CCNB2/SPDYE2/MAPK10/IGF1R	0.531101215186308
Organismal Systems	Endocrine system	hsa04911	Insulin secretion	22/2187	86/9376	1.09671313575993	KCNMA1/ADCY3/CREB5/ATP1A1/ATF4/KCNMB1/KCNN4/KCNMB4/PRKCG/ADCY9/ATF2/ATP1B3/KCNN1/GNAQ/CACNA1D/CAMK2D/PRKCB/RAPGEF4/ATP1B2/RAB3A/FXYD2/KCNN3	0.496938473198827
Metabolism	Amino acid metabolism	hsa00260	Glycine, serine and threonine metabolism	11/2187	41/9376	1.15021133750432	SDS/SDSL/ALAS1/DMGDH/MAOB/PIPOX/AOC3/CTH/AMT/MAOA/GLYCTK	0.531634636989857
Organismal Systems	Endocrine system	hsa04922	Glucagon signaling pathway	27/2187	107/9376	1.081804545979	ITPR1/PRKAG2/AKT3/CREB5/FOXO1/PPP4R3A/ATF4/SIRT1/CREBBP/LDHA/PPP3CC/EP300/FBP1/PFKP/GYS1/PPP4R3B/CPT1A/PYGB/LDHC/ATF2/PYGM/PHKA2/GNAQ/CALM1/CAMK2D/ACACB/CPT1B	0.469384424403147
Metabolism	Amino acid metabolism	hsa00250	Alanine, aspartate and glutamate metabolism	10/2187	37/9376	1.15868955375128	GLS/IL4I1/GLUL/GLUD1/GFPT1/ASL/PPAT/ASRGL1/ABAT/DDO	0.533426762830902
Environmental Information Processing	Signal transduction	hsa04310	Wnt signaling pathway	44/2187	178/9376	1.05974527725117	FOSL1/CUL1/NFATC1/PSEN1/PPARD/CTBP2/TLE3/TCF7/SIRT1/SMAD3/CREBBP/CACYBP/SIAH1/PPP3CC/EP300/RHOA/TCF7L2/WNT2B/CELSR1/MAPK8/PRKCG/CTNNB1/TBL1X/AXIN1/MYC/NKD1/CCDC88C/APC2/GSK3B/TLE1/CCN4/CSNK1A1/CAMK2D/CCND3/DKK1/PRKCB/WNT5A/SKP1/WNT5B/PORCN/MAPK10/WNT9A/FZD8/TLE2	0.443856584880419
Metabolism	Nucleotide metabolism	hsa00230	Purine metabolism	32/2187	128/9376	1.07178783721994	AMPD3/PNP/ADA/ADA2/ADK/ADCY3/PDE7A/PDE4A/PDE2A/PDE4B/LACC1/PDE8A/AK4/ADCY10/NT5C2/PAPSS2/PDE4C/ENTPD1/ENPP4/NT5E/AK2/GART/AMPD2/ADCY9/PDE1B/PPAT/PDE6D/PAICS/PDE6H/PDE6G/PDE6A/PRUNE1	0.45103239059422
Metabolism	Lipid metabolism	hsa00120	Primary bile acid biosynthesis	5/2187	17/9376	1.26092686731757	CYP7B1/CYP27A1/HSD3B7/AKR1D1/BAAT	0.593887692383779
Metabolism	Energy metabolism	hsa00910	Nitrogen metabolism	5/2187	17/9376	1.26092686731757	CA2/GLUL/GLUD1/CA13/CA5A	0.593887692383779
Genetic Information Processing	Replication and repair	hsa03460	Fanconi anemia pathway	14/2187	54/9376	1.1114836830429	HES1/REV3L/ERCC1/BRCA2/WDR48/BLM/TOP3A/MLH1/POLH/FANCI/FANCL/RMI2/SLX4/RAD51	0.453136897062496
Metabolism	Nucleotide metabolism	hsa00240	Pyrimidine metabolism	15/2187	59/9376	1.08995373276604	UPP1/TYMP/CMPK2/ASMTL/UPB1/DPYD/NT5C2/UCK2/ENTPD1/DPYS/NT5E/NT5C3A/CTPS1/CDA/CDADC1	0.382281195721603
Organismal Systems	Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	15/2187	59/9376	1.08995373276604	PTGS2/MGLL/PIK3CB/AKT3/ADCY3/IRS2/PIK3R1/ADRB2/PTGS1/ADCY9/GNAI3/PNPLA2/INSR/PIK3R3/PTGER3	0.382281195721603
Organismal Systems	Digestive system	hsa04971	Gastric acid secretion	19/2187	76/9376	1.07178783721994	ITPR1/CA2/EZR/ADCY3/SSTR2/SLC9A1/ATP1A1/PRKCG/ADCY9/GNAI3/ATP1B3/KCNJ15/GNAQ/MYLK3/CALM1/CAMK2D/PRKCB/ATP1B2/KCNJ2	0.346570808224112
Metabolism	Energy metabolism	hsa00920	Sulfur metabolism	3/2187	10/9376	1.28614540466392	SQOR/PAPSS2/ETHE1	0.499327502163765
Metabolism	Global and overview maps	hsa01200	Carbon metabolism	28/2187	116/9376	1.03482963593649	SDS/HK2/SDSL/ACAT2/GLUD1/PGD/OGDH/FBP1/FH/HK1/PFKP/TPI1/ACOX3/ENO1/SDHB/PGK1/DLST/TKFC/PC/ALDOB/TKTL1/ALDOC/HK3/ACOX1/ENO3/ME3/AMT/GLYCTK	0.208184419635557
Organismal Systems	Nervous system	hsa04724	Glutamatergic synapse	28/2187	116/9376	1.03482963593649	ITPR1/SLC1A3/GLS/ADCY3/GLUL/SLC38A2/HOMER1/PPP3CC/SLC1A2/GNB1/PLA2G4C/PRKCG/GNB4/MAPK1/GNGT2/GNG4/ADCY9/GNAI3/SLC38A1/GNAQ/CACNA1D/GNG7/PLA2G4A/PRKCB/GNG5/GRIK5/GRIN2D/GNB5	0.208184419635557
Genetic Information Processing	Transcription	hsa03022	Basal transcription factors	11/2187	44/9376	1.07178783721994	TAF4B/GTF2A1/TAF7/TAF5L/GTF2H1/CDK7/TAF2/TAF9/GTF2B/TAF5/CCNH	0.263248333446873
Organismal Systems	Excretory system	hsa04962	Vasopressin-regulated water reabsorption	11/2187	44/9376	1.07178783721994	DYNC1H1/ADCY3/CREB5/STX4/RAB5A/DYNC1LI1/ARHGDIA/ADCY9/RAB11A/ARHGDIB/AQP3	0.263248333446873
Genetic Information Processing	Translation	hsa03013	Nucleocytoplasmic transport	26/2187	108/9376	1.03209199139698	NXF1/IPO5/IPO7/EIF4A3/RBM8A/KPNA4/TNPO1/NUP98/NXT2/KPNA2/TNPO3/NUP58/NUP210L/NUP153/NUP188/RNPS1/UPF3B/NXT1/NUP62/ACIN1/RANGAP1/EEF1A1/RANBP2/DDX19A/NUP50/NUP210	0.185008345869577
Genetic Information Processing	Chromosome	hsa03082	ATP-dependent chromatin remodeling	28/2187	117/9376	1.02598493819344	BAZ1A/GATAD2A/INO80D/SRCAP/MBD2/BCL7B/CHD3/EPC2/CHRAC1/ING3/INO80/SMARCA5/PHF10/ARID2/GATAD2B/YY1/CHD4/RUVBL2/KAT5/BICRAL/EP400/SS18L1/SMARCD3/BPTF/MTA2/MORF4L2/ACTR8/INO80B	0.155994169000757
Metabolism	Glycan biosynthesis and metabolism	hsa00604	Glycosphingolipid biosynthesis - ganglio series	4/2187	15/9376	1.14324035970127	ST3GAL1/HEXB/HEXA/ST6GALNAC3	0.306214461926646
Organismal Systems	Immune system	hsa04610	Complement and coagulation cascades	21/2187	88/9376	1.02307020825539	ITGAX/C3/PLAUR/SERPINA1/SERPINB2/PLAU/THBD/C5AR1/SERPINE1/CD55/SERPING1/TFPI/VWF/CFH/F8/PROC/CD46/ITGB2/ITGAM/CPB2/SERPINF2	0.119924394821757
Organismal Systems	Environmental adaptation	hsa04713	Circadian entrainment	23/2187	97/9376	1.01654104148695	ITPR1/ADCY3/ADCY10/GNB1/RASD1/PRKCG/GNB4/MAPK1/GNGT2/GNG4/ADCY9/GNAI3/CACNA1G/PER1/GNAQ/CALM1/CACNA1D/CAMK2D/GNG7/PRKCB/GNG5/GRIN2D/GNB5	0.0903179181827347
Metabolism	Carbohydrate metabolism	hsa00010	Glycolysis / Gluconeogenesis	16/2187	67/9376	1.02379733704591	HK2/ALDH2/LDHA/FBP1/HK1/PFKP/TPI1/ENO1/ALDH3A2/PGK1/GALM/LDHC/ALDOB/ALDOC/HK3/ENO3	0.107817693212491
Organismal Systems	Digestive system	hsa04970	Salivary secretion	22/2187	93/9376	1.01416483521886	KCNMA1/ITPR1/LYZ/ADCY3/ATP2B1/SLC12A2/SLC9A1/ATP1A1/ADRB2/CD38/KCNN4/CST3/PRKCG/BST1/ADCY9/ATP1B3/GNAQ/CALM1/PRKCB/CAMP/ATP1B2/FXYD2	0.0757154684479161
Metabolism	Global and overview maps	hsa01232	Nucleotide metabolism	20/2187	85/9376	1.00874149385406	UPP1/AMPD3/PNP/ADA/ADA2/ADK/TYMP/CMPK2/ASMTL/LACC1/AK4/NT5C2/UCK2/ENTPD1/NT5E/AK2/NT5C3A/AMPD2/CTPS1/CDA	0.0446518726355607
Environmental Information Processing	Signal transduction	hsa04392	Hippo signaling pathway - multiple species	7/2187	29/9376	1.03482963593649	RASSF2/LATS2/PAK1/SAV1/MOB1A/MOB1B/FRMD6	0.10360664258717
Organismal Systems	Sensory system	hsa04744	Phototransduction	7/2187	29/9376	1.03482963593649	SLC24A1/GNB1/CALM1/PDE6G/PDE6A/GRK7/CNGB1	0.10360664258717
Metabolism	Amino acid metabolism	hsa00360	Phenylalanine metabolism	4/2187	16/9376	1.07178783721994	IL4I1/MAOB/AOC3/MAOA	0.158507101432389
Organismal Systems	Digestive system	hsa04976	Bile secretion	21/2187	90/9376	1.00033531473861	AQP9/CA2/SLC22A1/ADCY3/ABCC3/SLC9A1/ATP1A1/LDLR/NCEH1/RXRA/ADCY9/ABCB4/SLC10A1/ABCB1/ATP1B3/BAAT/SLC51A/SCARB1/ATP1B2/ABCC2/FXYD2	0.00176293112750545
Human Diseases	Immune disease	hsa05340	Primary immunodeficiency	9/2187	38/9376	1.01537795105047	CIITA/ADA/CD40/IL7R/TAP1/IL2RG/TAP2/BTK/RFX5	0.0523888814047528
Organismal Systems	Endocrine system	hsa04924	Renin secretion	16/2187	69/9376	0.994122051914144	KCNMA1/ITPR1/PTGER4/PTGER2/CTSB/ADRB2/PPP3CC/GNAI3/PDE1B/EDN1/GNAQ/CALM1/CACNA1D/ACE/REN/KCNJ2	-0.027028455068842
Human Diseases	Substance dependence	hsa05031	Amphetamine addiction	16/2187	69/9376	0.994122051914144	CREB5/ATF4/SIRT1/PPP3CC/ARC/PRKCG/ATF2/SLC6A3/CALM1/CACNA1D/CAMK2D/FOSB/MAOB/PRKCB/GRIN2D/MAOA	-0.027028455068842
Organismal Systems	Endocrine system	hsa04927	Cortisol synthesis and secretion	15/2187	65/9376	0.989342618972249	ITPR1/NR4A1/ADCY3/CREB5/ATF4/LDLR/PDE8A/NCEH1/ADCY9/ATF2/CACNA1G/GNAQ/CACNA1D/SP1/SCARB1	-0.047553752824095
Organismal Systems	Circulatory system	hsa04260	Cardiac muscle contraction	20/2187	87/9376	0.985552034225229	SLC9A7/SLC9A1/ATP1A1/ATP2A2/UQCRC2/ATP2A3/SLC8A2/SLC8A1/CACNA2D4/ATP1B3/CACNB2/CACNA1D/UQCRHL/TPM4/ATP2A1/CACNG2/TPM3/ATP1B2/CACNB1/FXYD2	-0.0746719747987905
Cellular Processes	Transport and catabolism	hsa04146	Peroxisome	19/2187	83/9376	0.98139609191223	SOD2/ACSL5/ACSL3/ACSL1/ACSL4/ACOX3/DHRS4/PEX13/PHYH/ABCD1/MPV17L2/FAR2/PEX5/ACOX1/BAAT/PIPOX/NUDT13/SLC25A17/DDO	-0.0938946939609714
Metabolism	Metabolism of other amino acids	hsa00450	Selenocompound metabolism	4/2187	17/9376	1.00874149385406	TXNRD1/PAPSS2/CTH/KYAT1	0.0198962478120531
Metabolism	Carbohydrate metabolism	hsa00030	Pentose phosphate pathway	7/2187	31/9376	0.968066433618007	PGD/FBP1/PFKP/ALDOB/TKTL1/ALDOC/GLYCTK	-0.0982232739441522
Genetic Information Processing	Folding, sorting and degradation	hsa03060	Protein export	7/2187	31/9376	0.968066433618007	HSPA5/SRP54/SRPRA/SRP72/SPCS3/SGTA/SEC63	-0.0982232739441522
Metabolism	Amino acid metabolism	hsa00340	Histidine metabolism	5/2187	22/9376	0.974352579290851	ALDH2/ALDH3A2/MAOB/CNDP1/MAOA	-0.0664250884494967
Metabolism	Glycan biosynthesis and metabolism	hsa00514	Other types of O-glycan biosynthesis	11/2187	49/9376	0.962421731381167	LFNG/GALNT6/GALNT2/GALNT4/B4GALT1/GALNT7/OGT/GALNT15/POGLUT1/GALNT3/GALNT18	-0.145458667923775
Human Diseases	Substance dependence	hsa05030	Cocaine addiction	11/2187	49/9376	0.962421731381167	NFKB1/CREB5/ATF4/RELA/GNAI3/ATF2/SLC6A3/FOSB/MAOB/GRIN2D/MAOA	-0.145458667923775
Metabolism	Carbohydrate metabolism	hsa00650	Butanoate metabolism	6/2187	27/9376	0.952700299751054	ACAT2/HMGCS1/AACS/ABAT/L2HGDH/ACSM3	-0.135748012139669
Metabolism	Amino acid metabolism	hsa00330	Arginine and proline metabolism	11/2187	50/9376	0.943173296753544	SAT1/ALDH2/P4HA1/CKB/SMS/AMD1/ALDH3A2/SMOX/MAOB/CNDP1/MAOA	-0.222210996043581
Human Diseases	Cancer: overview	hsa05206	MicroRNAs in cancer	73/2187	323/9376	0.968922750675608	CDKN1A/VEGFA/ITGA5/CD44/PTGS2/EZH2/VIM/BCL2/SLC7A1/NFKB1/MAP2K1/PIK3CB/PLAU/ST14/GLS/EZR/THBS1/NOTCH2/RDX/DDIT4/SOX4/MMP9/PRKCE/BCL2L11/RAF1/IRS2/MCL1/MDM2/PIK3R1/CYP1B1/SIRT1/HMGA2/SOCS1/PLCG2/CREBBP/RPTOR/EP300/KRAS/RHOA/NOTCH1/HMOX1/NRAS/TNC/PDGFB/PRKCG/MET/HDAC4/GRB2/EFNA2/MAPK1/ITGB3/PDGFA/SPRY2/CASP3/ZEB1/ABCB1/MYC/PTEN/DICER1/FOXP1/E2F3/BMF/APC2/PIK3R3/STAT3/MARCKS/PRKCB/SLC45A3/CCNE2/TGFB2/TIMP3/NOTCH4/EFNA1	-0.313489761123346
Metabolism	Metabolism of terpenoids and polyketides	hsa00900	Terpenoid backbone biosynthesis	5/2187	23/9376	0.93198942366951	PDSS1/ACAT2/HMGCS1/NUS1/IDI2	-0.180111189273482
Genetic Information Processing	Folding, sorting and degradation	hsa03050	Proteasome	10/2187	46/9376	0.93198942366951	PSMD14/PSMD12/PSMA6/PSMD11/PSMB9/PSMD7/PSMB7/PSMD1/PSME1/PSME4	-0.255029451595822
Metabolism	Lipid metabolism	hsa00062	Fatty acid elongation	6/2187	28/9376	0.918675289045659	ELOVL5/ELOVL7/PPT1/ACAA2/ACOT7/HACD1	-0.237693869155868
Metabolism	Glycan biosynthesis and metabolism	hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	6/2187	28/9376	0.918675289045659	ST3GAL6/B3GNT5/B3GNT2/B4GALT1/GCNT2/FUT4	-0.237693869155868
Metabolism	Carbohydrate metabolism	hsa00620	Pyruvate metabolism	10/2187	47/9376	0.912159861463775	ALDH2/ACAT2/LDHA/FH/ALDH3A2/LDHC/PC/ME3/ACACB/LDHD	-0.332966225044312
Metabolism	Glycan biosynthesis and metabolism	hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	5/2187	24/9376	0.893156531016613	XYLT1/HS3ST2/HS3ST1/HS3ST3B1/NDST1	-0.289052772872014
Metabolism	Global and overview maps	hsa01230	Biosynthesis of amino acids	16/2187	75/9376	0.914592287761012	SDS/GLUL/SDSL/BCAT1/MAT2A/PFKP/TPI1/ENO1/PGK1/PC/ALDOB/ASL/TKTL1/ALDOC/ENO3/CTH	-0.409579947766136
Organismal Systems	Digestive system	hsa04975	Fat digestion and absorption	9/2187	43/9376	0.897310747439946	ACAT2/ABCA1/APOA1/APOB/SLC27A1/DGAT1/DGAT2/SCARB1/PLPP1	-0.372241145150472
Genetic Information Processing	Transcription	hsa03020	RNA polymerase	7/2187	34/9376	0.8826488071223	CRCP/POLR3C/POLR1C/POLR2A/POLR1B/POLR1E/POLR3D	-0.378079233245832
NA	NA	hsa04081	Hormone signaling	48/2187	219/9376	0.939649610713368	SRC/PIK3CB/ITGAV/GNA12/ADCY3/SSTR2/HAMP/STAT5A/ADIPOR2/IRS2/PIK3R1/GNA13/ADRB2/RHOA/GNB1/GIPR/ACVR1/GNA15/CSH2/THRB/ADRA2B/GNB4/ITGB3/GNGT2/GNG4/ESR1/ADCY9/OXTR/GNAI3/INSR/STAT5B/GHRL/RAMP1/CRH/ADRA2C/GNAQ/PIK3R3/STAT3/GNG7/RAMP3/GNG5/OPRM1/MC1R/SLC16A10/RAPGEF4/GNB5/BMPR1B/IGF1R	-0.498426717524018
Metabolism	Metabolism of cofactors and vitamins	hsa00670	One carbon pool by folate	8/2187	39/9376	0.879415661308665	MTHFD2/MAT2A/MTHFD2L/AHCYL1/GART/DMGDH/CTH/AMT	-0.41619352372528
Metabolism	Glycan biosynthesis and metabolism	hsa00513	Various types of N-glycan biosynthesis	9/2187	44/9376	0.876917321361766	STT3B/MGAT1/HEXB/MAN2A1/MAGT1/B4GALT1/MAN2A2/HEXA/ALG13	-0.451348184908042
Human Diseases	Cancer: overview	hsa05208	Chemical carcinogenesis - reactive oxygen species	49/2187	227/9376	0.925420335220738	VEGFA/AHR/PPIF/NFKBIA/SOD2/SRC/NFKB1/ABL2/MAP2K1/PIK3CB/AKT3/NFE2L2/MAPK13/PTPN1/RAF1/GSTO2/PIK3R1/CYP1B1/GSTO1/KRAS/UQCRC2/RELA/HMOX1/NRAS/PTPN11/MAPK8/PDPK1/MET/SDHB/GRB2/MAPK1/PRKCD/FOXO3/BRAF/PTEN/NCF2/MAP2K4/MAP3K5/PIK3R3/UQCRHL/MAP3K14/AKR1C3/NCF1/MT-ATP8/MAPK10/EPHX3/HIF1A/AS3MT/PTPRJ	-0.627367951890236
Metabolism	Lipid metabolism	hsa00592	alpha-Linolenic acid metabolism	5/2187	26/9376	0.824452182476874	PLA2G6/ACOX3/PLA2G4C/ACOX1/PLA2G4A	-0.494369980105475
Human Diseases	Neurodegenerative disease	hsa05012	Parkinson disease	58/2187	268/9376	0.927816336697855	ERN1/PPIF/UBC/ITPR1/TUBB6/EIF2AK3/TUBB4B/NFE2L2/HSPA5/DDIT3/ADORA2A/GNAL/TXN/TUBA1C/ATF4/SLC39A10/CYCS/SLC39A8/PSMD14/PSMD12/UBE2J1/PSMA6/PSMD11/TUBA4A/PSMD7/UQCRC2/UBE2L6/PSMB7/UBA1/PSMD1/KIF5B/MAPK8/SDHB/SLC39A9/EIF2S1/MCU/CASP3/UBE2G1/SLC11A2/MFN1/GNAI3/SLC39A11/LRRK2/SLC6A3/SLC39A14/BCL2L1/MAP3K5/CALM1/CAMK2D/UQCRHL/XBP1/MAOB/MT-ATP8/CASP9/DUSP1/ATF6/MAPK10/MAOA	-0.661257472166764
Metabolism	Carbohydrate metabolism	hsa00640	Propanoate metabolism	6/2187	32/9376	0.803840877914952	LDHA/ACOX3/LDHC/ACOX1/ABAT/ACACB	-0.613045729316448
Cellular Processes	Cell motility	hsa04814	Motor proteins	41/2187	194/9376	0.906047450020977	MYO9B/TUBB6/TUBB4B/KIF13B/DYNC1H1/MYH9/MYO1G/ACTG2/DNAH17/TUBA1C/MYH11/MYO16/DYNC1LI1/DNAI2/KIF21B/TUBA4A/KIF5B/KIFC3/ACTR1B/KIF13A/MYL9/HOOK3/MYO18A/ACTA2/TNNI2/MYO5C/DNAH3/MYO1D/TPM4/MYO7B/KIF21A/MYO1E/KIF14/KIFC1/CENPE/MYO15A/DNAH11/DNAH12/TPM3/KIFC2/DNAH2	-0.729317409158427
Metabolism	Metabolism of other amino acids	hsa00430	Taurine and hypotaurine metabolism	3/2187	17/9376	0.756556120390543	BAAT/GADL1/ADO	-0.554095196759673
NA	NA	hsa04082	Neuroactive ligand signaling	42/2187	199/9376	0.904825912828891	SLC1A3/ADCY3/ADORA2A/GNAL/P2RX4/ADORA2B/ADRB2/OGFRL1/HTR7/SLC1A2/GNB1/P2RX1/PRKCG/ADRA2B/GNB4/GNGT2/GNG4/ADCY9/GNAI3/P2RY14/GABBR1/SLC6A3/ACHE/SLC17A9/ADORA3/P2RY6/ADRA2C/GNAQ/P2RY1/GNG7/GABRR2/PRKCB/GNG5/OPRM1/AGRP/GRIK5/CHRFAM7A/HTR2B/GRIN2D/GNB5/TAC4/SLC6A12	-0.748463593489098
Metabolism	Metabolism of cofactors and vitamins	hsa00790	Folate biosynthesis	5/2187	28/9376	0.765562740871383	GCH1/FPGS/GGH/AKR1C3/GPHN	-0.685207466988281
Metabolism	Amino acid metabolism	hsa00220	Arginine biosynthesis	4/2187	23/9376	0.745591538935608	GLS/GLUL/GLUD1/ASL	-0.673745363675169
Metabolism	Glycan biosynthesis and metabolism	hsa00515	Mannose type O-glycan biosynthesis	4/2187	23/9376	0.745591538935608	B4GALT1/B3GALNT2/FUT4/FKRP	-0.673745363675169
Metabolism	Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	9/2187	48/9376	0.803840877914952	IL4I1/ALDH2/ACAT2/BCAT1/HMGCS1/ACAA2/ALDH3A2/AACS/ABAT	-0.751468268931807
Organismal Systems	Digestive system	hsa04980	Cobalamin transport and metabolism	3/2187	18/9376	0.714525224813291	ZNF143/TCN2/MMACHC	-0.668633696681865
Metabolism	Amino acid metabolism	hsa00310	Lysine degradation	12/2187	63/9376	0.816600256929475	EZH2/DOT1L/KMT2E/ALDH2/PRDM2/ACAT2/SETDB2/ALDH3A2/DLST/ASH1L/KMT2C/PIPOX	-0.805563878264646
Genetic Information Processing	Replication and repair	hsa03450	Non-homologous end-joining	2/2187	13/9376	0.659561745981499	XRCC6/NHEJ1	-0.677451653134177
Metabolism	Global and overview maps	hsa01240	Biosynthesis of cofactors	31/2187	154/9376	0.862997998800468	KMO/KYNU/GCH1/MTHFD2/GCLC/ALDH2/CMPK2/BCAT1/MAT2A/MTHFD2L/GCLM/FPGS/AK4/PMM2/GUSB/PDXK/ALDH3A2/ALAS1/AK2/OXSM/AFMID/GGH/DHRS3/RFK/UGP2/NADK/CTPS1/RDH13/GPHN/COQ3/RDH12	-0.94547598083068
Metabolism	Metabolism of cofactors and vitamins	hsa00785	Lipoic acid metabolism	3/2187	19/9376	0.676918634033644	OGDH/DLST/AMT	-0.777492456477837
Metabolism	Carbohydrate metabolism	hsa00020	Citrate cycle (TCA cycle)	5/2187	30/9376	0.714525224813291	OGDH/FH/SDHB/DLST/PC	-0.863756376628644
Genetic Information Processing	Transcription	hsa03040	Spliceosome	50/2187	243/9376	0.882129907176902	HNRNPC/HSPA6/RBM22/FUS/EIF4A3/RBM8A/SNIP1/CTNNBL1/SLU7/SRSF2/PRPF40B/PRPF40A/SF3B2/SMNDC1/HNRNPM/PUF60/SNRPB/SRSF4/DDX5/WBP11/SRSF5/CWC25/SF3B1/PRPF38B/HSPA8/CDC5L/SNW1/HSPA1B/SNRPA/ISY1/DHX8/PRPF3/YJU2/SRSF3/PQBP1/ACIN1/RBM25/CHERP/DHX38/HNRNPA3/PRPF4/RBMXL1/HSPA1A/PCBP1/HSPA1L/HNRNPU/U2AF1L4/TRA2B/HNRNPA1/SRSF7	-1.02677626613667
Human Diseases	Neurodegenerative disease	hsa05020	Prion disease	57/2187	275/9376	0.888609552313256	IL1B/PPIF/IL1A/ITPR1/TUBB6/EIF2AK3/PIK3CB/TUBB4B/HSPA5/HSPA6/CREB5/DDIT3/IL6/MAPK13/TUBA1C/ATF4/CYCS/PIK3R1/FYN/PSMD14/STIP1/PSMD12/TNF/PSMA6/PSMD11/TUBA4A/PPP3CC/PSMD7/PRNP/UQCRC2/PSMB7/NOTCH1/PSMD1/HSPA8/HSPA1B/KIF5B/MAPK8/SDHB/MAPK1/EIF2S1/PRKCD/NCAM1/MCU/CASP3/ATF2/HSPA1A/HSPA1L/NCF2/GSK3B/PIK3R3/CACNA1D/UQCRHL/NCF1/MT-ATP8/CASP9/GRIN2D/MAPK10	-1.03405949567664
Metabolism	Lipid metabolism	hsa00565	Ether lipid metabolism	9/2187	51/9376	0.756556120390543	LPCAT1/PAFAH1B1/PLA2G6/PLA2G4C/CHPT1/SELENOI/PLD3/PLA2G4A/PLPP1	-0.961469066561358
Genetic Information Processing	Replication and repair	hsa03440	Homologous recombination	7/2187	41/9376	0.731952669320932	NBN/RBBP8/BRCA2/BLM/TOP3A/RAD54L/RAD51	-0.948685017451273
Metabolism	Carbohydrate metabolism	hsa00630	Glyoxylate and dicarboxylate metabolism	5/2187	31/9376	0.691476024012862	GLUL/ACAT2/AFMID/AMT/GLYCTK	-0.948977469325557
Metabolism	Metabolism of cofactors and vitamins	hsa00730	Thiamine metabolism	2/2187	15/9376	0.571620179850633	AK4/AK2	-0.915776087136659
Metabolism	Glycan biosynthesis and metabolism	hsa00510	N-Glycan biosynthesis	9/2187	56/9376	0.689006466784245	STT3B/MGAT1/MAN2A1/MAGT1/SRD5A3/B4GALT1/MAN2A2/DHRSX/ALG13	-1.28739910734234
Metabolism	Metabolism of cofactors and vitamins	hsa00860	Porphyrin metabolism	7/2187	46/9376	0.652392596568657	FTH1/HMOX1/GUSB/HCCS/ALAS1/CP/FTL	-1.30347558057672
Organismal Systems	Immune system	hsa04613	Neutrophil extracellular trap formation	37/2187	195/9376	0.813459486710515	FPR3/PPIF/C3/AQP9/SRC/NFKB1/MAP2K1/PIK3CB/AKT3/C5AR1/MAPK13/RAF1/PIK3R1/PLCG2/CASP1/RELA/VWF/AZU1/FPR1/PRKCG/HDAC4/MAPK1/ITGB3/TLR2/FCGR2A/NCF2/SIGLEC9/CLEC7A/PIK3R3/ITGB2/ITGAM/NCF1/PRKCB/MPO/CAMP/HDAC6/PADI4	-1.45184839010218
Human Diseases	Cardiovascular disease	hsa05415	Diabetic cardiomyopathy	39/2187	205/9376	0.81560440295761	PPIF/NFKB1/PIK3CB/AKT3/CTSD/MAPK13/MMP9/ATP2A2/PIK3R1/SMAD3/TGFB1/UQCRC2/RELA/GYS1/SMAD2/MAPK8/PRKCG/SDHB/PRKCD/ATP2A3/PTEN/GFPT1/INSR/NCF2/GSK3B/PIK3R3/CAMK2D/UQCRHL/SP1/NCF1/ATP2A1/PRKCB/ACE/MT-ATP8/PLN/REN/TGFB2/CPT1B/MAPK10	-1.47229527585489
Metabolism	Lipid metabolism	hsa00590	Arachidonic acid metabolism	10/2187	63/9376	0.680500214107896	PTGS2/PLA2G6/LTA4H/PTGS1/PLA2G4C/PTGES3/AKR1C3/PLA2G4A/ALOX5/ALOX15B	-1.40336885057137
Genetic Information Processing	Replication and repair	hsa03420	Nucleotide excision repair	10/2187	63/9376	0.680500214107896	ERCC1/DDB1/GTF2H1/CDK7/RAD23A/CUL4A/DDB2/RAD23B/POLR2A/CCNH	-1.40336885057137
NA	NA	hsa04981	Folate transport and metabolism	4/2187	31/9376	0.553180819210289	ABCC3/FPGS/SLC19A1/ABCC2	-1.37435456701626
Metabolism	Metabolism of cofactors and vitamins	hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	1/2187	12/9376	0.357262612406645	COQ3	-1.22876624267934
Metabolism	Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	13/2187	82/9376	0.679670335798008	UPP1/TYMP/GSTO2/UPB1/DPYD/GSTO1/UCK2/GUSB/TPMT/DPYS/MPO/CDA/CDADC1	-1.60686184486994
Organismal Systems	Nervous system	hsa04723	Retrograde endocannabinoid signaling	26/2187	149/9376	0.748093523965593	PTGS2/MGLL/ITPR1/ADCY3/MAPK13/GNB1/MAPK8/PRKCG/GNB4/MAPK1/GNGT2/GNG4/DAGLA/ADCY9/GNAI3/DAGLB/ABHD6/CNR1/GNAQ/CACNA1D/GNG7/GABRR2/PRKCB/GNG5/GNB5/MAPK10	-1.70953499065893
Human Diseases	Neurodegenerative disease	hsa05016	Huntington disease	58/2187	308/9376	0.807320708555276	ERN1/PPIF/SOD2/ITPR1/TUBB6/SLC1A3/TAF4B/TUBB4B/CREB5/DNAH17/TUBA1C/RB1CC1/CYCS/RCOR1/DNAI2/PSMD14/PSMD12/ATG13/CREBBP/PSMA6/PSMD11/TUBA4A/PSMD7/EP300/UQCRC2/CASP8/SIN3A/PSMB7/PSMD1/SLC1A2/PPARG/ATG101/GPX3/BECN1/KIF5B/MAPK8/ACTR1B/SDHB/TGM2/HIP1/CASP3/DNAH3/MAP3K5/ATG2A/GNAQ/POLR2A/UQCRHL/SP1/TRAF2/WIPI1/MT-ATP8/CASP9/ULK1/ATG2B/DNAH11/DNAH12/MAPK10/DNAH2	-1.89640211505245
Metabolism	Metabolism of other amino acids	hsa00480	Glutathione metabolism	8/2187	59/9376	0.58130865747522	GCLC/ANPEP/GSTO2/GCLM/PGD/GSTO1/SMS/GPX3	-1.77933502187125
Metabolism	Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	4/2187	36/9376	0.476350149875527	GUSB/UGP2/FGGY/DHDH	-1.73617933922244
Metabolism	Lipid metabolism	hsa00591	Linoleic acid metabolism	3/2187	30/9376	0.428715134887974	PLA2G6/PLA2G4C/PLA2G4A	-1.7285273095993
Metabolism	Lipid metabolism	hsa00140	Steroid hormone biosynthesis	9/2187	66/9376	0.584611547574511	DHRS9/CYP1B1/SRD5A3/CYP7B1/SRD5A1/AKR1D1/HSD11B2/AKR1C3/HSD17B7	-1.86778694008282
Human Diseases	Substance dependence	hsa05034	Alcoholism	33/2187	191/9376	0.740712013157233	MAP2K1/CREB5/ADORA2A/ATF4/RAF1/ADORA2B/CAMKK2/KRAS/GNB1/NRAS/SHC3/HDAC4/GRB2/GNB4/MAPK1/BRAF/GNGT2/GNG4/GNAI3/ATF2/SLC6A3/CAMKK1/CRH/CALM1/SLC29A1/GNG7/FOSB/MAOB/GNG5/GRIN2D/HDAC6/GNB5/MAOA	-1.99680330585973
Metabolism	Amino acid metabolism	hsa00350	Tyrosine metabolism	4/2187	37/9376	0.463475821500513	IL4I1/MAOB/AOC3/MAOA	-1.80349839641022
Metabolism	Carbohydrate metabolism	hsa00053	Ascorbate and aldarate metabolism	3/2187	31/9376	0.414885614407717	ALDH2/GUSB/ALDH3A2	-1.79973166470696
Metabolism	Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9/2187	68/9376	0.567417090292907	ALDH1A2/DHRS9/DHRS4/CYP2S1/ALDH1A1/DHRS3/DGAT1/RDH13/RDH12	-1.97456490813562
Organismal Systems	Environmental adaptation	hsa04714	Thermogenesis	41/2187	235/9376	0.747971086400296	MAP2K3/MGLL/PRKAG2/ACSL5/RPS6KA3/ADCY3/CREB5/ZNF516/ACSL3/RHEB/MAPK13/ACSL1/ACSL4/RPTOR/ADCY10/KRAS/UQCRC2/PPARG/KDM1A/NRAS/CPT1A/SDHB/GRB2/RPS6KB1/ADCY9/SLC25A29/RPS6KA2/ATF2/KDM3A/PNPLA2/SMARCD3/BMP8A/CNR1/AKT1S1/MAP3K5/UQCRHL/MT-ATP8/KDM3B/COA7/CPT1B/FGFR1	-2.15805859293246
Metabolism	Global and overview maps	hsa01210	2-Oxocarboxylic acid metabolism	3/2187	33/9376	0.38974103171634	BCAT1/OGDH/DLST	-1.93688463463476
Human Diseases	Endocrine and metabolic disease	hsa04950	Maturity onset diabetes of the young	2/2187	26/9376	0.32978087299075	HES1/MAFA	-1.88744138868159
NA	NA	hsa04519	Cadherin signaling	73/2187	404/9376	0.774658535812429	MAP2K3/LHFPL2/VIM/MRAS/NFKBIA/NFKB1/PTK2B/MAP2K1/ACTN1/MYO1G/PSEN1/LATS2/MAPK13/CDH23/ERBIN/DES/RAF1/TCF7/YWHAG/YWHAQ/CREBBP/SAV1/EP300/KRAS/YWHAH/RELA/RHOA/SHOC2/CTNNA1/NRAS/TCF7L2/WNT2B/MOB1A/ACTR3/CELSR1/YWHAZ/MOB1B/MAPK8/MET/CTNNB1/CDC42/VASP/MAPK1/TAOK3/CDH13/JUP/VCL/AXIN1/DSC2/APC2/CYFIP2/GSK3B/CSNK1A1/VAV2/MYO1D/FMN1/GABRR2/WNT5A/ACTR3B/FLT4/MYO1E/ARPC5/WNT5B/PCDH9/MAPK10/LHFPL5/WNT9A/TMC4/LHFPL3/FZD8/IGF1R/FGFR1/PKP2	-2.55365927119251
Human Diseases	Immune disease	hsa05322	Systemic lupus erythematosus	21/2187	143/9376	0.629581666618704	HLA-DQA1/HLA-DQB1/HLA-DRB5/HLA-DRB1/HLA-DPB1/HLA-DQA2/HLA-DPA1/HLA-DMA/C3/HLA-DRA/HLA-DOA/CD80/ACTN1/HLA-DMB/HLA-DQB2/IL10/TNF/CD40/SNRPB/RO60/FCGR2A	-2.46186856097721
Metabolism	Glycan biosynthesis and metabolism	hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	2/2187	30/9376	0.285810089925316	PIGA/PGAP1	-2.16091277608462
NA	NA	hsa04382	Cornified envelope formation	35/2187	217/9376	0.691476024012862	ST14/PLEC/UGCG/PPP2CA/DST/LAMB3/PPP2R2D/PPP2R2A/S100A8/S100A10/PADI2/KDSR/PPP2R3A/PPP2R3C/S100A4/CLDN1/JUP/CLDN12/BLMH/TCHH/PPP2R1B/PPP2R5A/CLDN14/S100A11/COL7A1/S100A2/PNPLA1/SLC27A1/ITGB4/LAMA3/S100A12/PCSK6/EPHX3/CLDN4/PKP2	-2.53612435593952
Genetic Information Processing	Replication and repair	hsa03430	Mismatch repair	1/2187	23/9376	0.186397884733902	MLH1	-2.15464788688023
Human Diseases	Substance dependence	hsa05033	Nicotine addiction	3/2187	41/9376	0.313694001137542	GABRR2/CHRFAM7A/GRIN2D	-2.4290046718924
Genetic Information Processing	Replication and repair	hsa03410	Base excision repair	3/2187	44/9376	0.292305773787255	POLG/APTX/POLG2	-2.59513773997279
Genetic Information Processing	Replication and repair	hsa03030	DNA replication	1/2187	36/9376	0.119087537468882	DNA2	-2.92069598940311
Metabolism	Energy metabolism	hsa00190	Oxidative phosphorylation	15/2187	138/9376	0.465994711834755	ATP6V1H/CYCS/ATP6V1A/UQCRC2/ATP6V0D1/ATP6V1B2/ATP6V1C1/ATP6V1E1/SDHB/TCIRG1/ATP6V1F/UQCRHL/ATP6V0D2/MT-ATP8/ATP6V1E2	-3.48555475855865
Environmental Information Processing	Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	56/2187	370/9376	0.648866150100718	FPR3/ADM/C3/C5AR1/SSTR2/ADORA2A/PTGER4/P2RX4/PTGER2/P2RX7/ADORA2B/ADRB2/NR3C1/OGFRL1/HTR7/GPR35/CHRNE/GIPR/P2RY8/P2RX1/CSH2/FPR1/THRB/ADRA2B/OXTR/CALCRL/MAS1/NMB/P2RY14/GABBR1/CHRNA5/CNR1/GHRL/EDN1/CRH/ADORA3/P2RY6/ADRA2C/P2RY1/PTGER3/GABRR2/NTSR1/OPRM1/MC1R/CYSLTR2/PTGIR/GRIK5/LPAR3/CHRFAM7A/HTR2B/GRIN2D/LPAR1/TAC4/GPR156/LPAR2/S1PR4	-3.80087315964478
Human Diseases	Cancer: overview	hsa05204	Chemical carcinogenesis - DNA adducts	4/2187	70/9376	0.244980077078843	PTGS2/GSTO2/CYP1B1/GSTO1	-3.49704882161045
Organismal Systems	Sensory system	hsa04742	Taste transduction	6/2187	86/9376	0.299103582479982	TAS1R1/PKD2L1/GABBR1/PDE1B/P2RY1/KCNK5	-3.60139698559146
Metabolism	Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5/2187	79/9376	0.271338692967072	GSTO2/CYP1B1/GSTO1/CYP2S1/DHDH	-3.58710117771855
Metabolism	Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4/2187	73/9376	0.234912402678342	GSTO2/GSTO1/MAOB/MAOA	-3.61940239352297
Genetic Information Processing	Translation	hsa03008	Ribosome biogenesis in eukaryotes	20/2187	183/9376	0.468541131025109	NXF1/TCOF1/GTPBP4/NOP58/NXT2/GNL3/GNL2/REXO1/NOP56/WDR43/NXT1/LSG1/RIOK1/UTP6/NAT10/EFL1/FCF1/RMRP/UTP14A/UTP15	-4.00444526322211
Genetic Information Processing	Translation	hsa03010	Ribosome	6/2187	222/9376	0.115868955375128	MRPL18/RPS4Y1/MRPL39/RPS10-NUDT3/RPS26/RPS20	-7.35298129822603
Organismal Systems	Sensory system	hsa04740	Olfactory transduction	14/2187	449/9376	0.133675097737898	ADCY3/GNAL/RGS2/PDE2A/GNB1/SLC8A2/SLC8A1/PDE1B/CALM1/CAMK2D/GNG7/SLC24A4/CNGA4/CNGB1	-10.3759289513593